Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Peter Libby, M.D.

Co-Author

This page shows the publications co-authored by Peter Libby and Guo-Ping Shi.
Connection Strength

7.930
  1. Libby P, Sukhova GK, Ozaki CK, Shi GP. Tilting at the tilted protease balance in arterial aneurysmal disease. Cardiovasc Res. 2017 09 01; 113(11):1279-1281.
    View in: PubMed
    Score: 0.800
  2. Libby P, Shi GP. Mast cells as mediators and modulators of atherogenesis. Circulation. 2007 May 15; 115(19):2471-3.
    View in: PubMed
    Score: 0.392
  3. Liu CL, Ren J, Wang Y, Zhang X, Sukhova GK, Liao M, Santos M, Luo S, Yang D, Xia M, Inouye K, Hotamisligil GS, Lu G, Upchurch GR, Libby P, Guo J, Zhang J, Shi GP. Adipocytes promote interleukin-18 binding to its receptors during abdominal aortic aneurysm formation in mice. Eur Heart J. 2020 Jul 07; 41(26):2456-2468.
    View in: PubMed
    Score: 0.243
  4. Liu CL, Liu X, Wang Y, Deng Z, Liu T, Sukhova GK, Wojtkiewicz GR, Tang R, Zhang JY, Achilefu S, Nahrendorf M, Libby P, Wang X, Shi GP. Reduced Nhe1 (Na+-H+ Exchanger-1) Function Protects ApoE-Deficient Mice From Ang II (Angiotensin II)-Induced Abdominal Aortic Aneurysms. Hypertension. 2020 Jul; 76(1):87-100.
    View in: PubMed
    Score: 0.242
  5. Liu T, Luo S, Libby P, Shi GP. Cathepsin L-selective inhibitors: A potentially promising treatment for COVID-19 patients. Pharmacol Ther. 2020 09; 213:107587.
    View in: PubMed
    Score: 0.242
  6. Liu CL, Zhang X, Liu J, Wang Y, Sukhova GK, Wojtkiewicz GR, Liu T, Tang R, Achilefu S, Nahrendorf M, Libby P, Guo J, Zhang JY, Shi GP. Na+-H+ exchanger 1 determines atherosclerotic lesion acidification and promotes atherogenesis. Nat Commun. 2019 09 04; 10(1):3978.
    View in: PubMed
    Score: 0.230
  7. Zhang X, Zhou Y, Yu X, Huang Q, Fang W, Li J, Bonventre JV, Sukhova GK, Libby P, Shi GP. Differential Roles of Cysteinyl Cathepsins in TGF-ß Signaling and Tissue Fibrosis. iScience. 2019 Sep 27; 19:607-622.
    View in: PubMed
    Score: 0.229
  8. Zhang X, Huang Q, Wang X, Deng Z, Li J, Yan X, Jauhiainen M, Metso J, Libby P, Liu J, Shi GP. Dietary cholesterol is essential to mast cell activation and associated obesity and diabetes in mice. Biochim Biophys Acta Mol Basis Dis. 2019 06 01; 1865(6):1690-1700.
    View in: PubMed
    Score: 0.223
  9. Fang W, He A, Xiang MX, Lin Y, Wang Y, Li J, Yang C, Zhang X, Liu CL, Sukhova GK, Barascuk N, Larsen L, Karsdal M, Libby P, Shi GP. Cathepsin K-deficiency impairs mouse cardiac function after myocardial infarction. J Mol Cell Cardiol. 2019 02; 127:44-56.
    View in: PubMed
    Score: 0.217
  10. Wang J, Cheng X, Xiang MX, Alanne-Kinnunen M, Wang JA, Chen H, He A, Sun X, Lin Y, Tang TT, Tu X, Sjöberg S, Sukhova GK, Liao YH, Conrad DH, Yu L, Kawakami T, Kovanen PT, Libby P, Shi GP. IgE stimulates human and mouse arterial cell apoptosis and cytokine expression and promotes atherogenesis in Apoe-/- mice. J Clin Invest. 2018 11 01; 128(11):5184.
    View in: PubMed
    Score: 0.217
  11. Liu CL, Guo J, Zhang X, Sukhova GK, Libby P, Shi GP. Cysteine protease cathepsins in cardiovascular disease: from basic research to clinical trials. Nat Rev Cardiol. 2018 06; 15(6):351-370.
    View in: PubMed
    Score: 0.211
  12. Zhou Y, Chen H, Liu L, Yu X, Sukhova GK, Yang M, Zhang L, Kyttaris VC, Tsokos GC, Stillman IE, Ichimura T, Bonventre JV, Libby P, Shi GP. CD74 Deficiency Mitigates Systemic Lupus Erythematosus-like Autoimmunity and Pathological Findings in Mice. J Immunol. 2017 04 01; 198(7):2568-2577.
    View in: PubMed
    Score: 0.193
  13. Zhou Y, Chen H, Liu L, Yu X, Sukhova GK, Yang M, Kyttaris VC, Stillman IE, Gelb B, Libby P, Tsokos GC, Shi GP. Cathepsin K Deficiency Ameliorates Systemic Lupus Erythematosus-like Manifestations in Faslpr Mice. J Immunol. 2017 03 01; 198(5):1846-1854.
    View in: PubMed
    Score: 0.191
  14. Liu CL, Wemmelund H, Wang Y, Liao M, Lindholt JS, Johnsen SP, Vestergaard H, Fernandes C, Sukhova GK, Cheng X, Zhang JY, Yang C, Huang X, Daugherty A, Levy BD, Libby P, Shi GP. Asthma Associates With Human Abdominal Aortic Aneurysm and Rupture. Arterioscler Thromb Vasc Biol. 2016 Mar; 36(3):570-8.
    View in: PubMed
    Score: 0.179
  15. Liu CL, Wang Y, Liao M, Santos MM, Fernandes C, Sukhova GK, Zhang JY, Cheng X, Yang C, Huang X, Levy B, Libby P, Wu G, Shi GP. Allergic lung inflammation promotes atherosclerosis in apolipoprotein E-deficient mice. Transl Res. 2016 May; 171:1-16.
    View in: PubMed
    Score: 0.179
  16. Liu CL, Wang Y, Liao M, Wemmelund H, Ren J, Fernandes C, Zhou Y, Sukhova GK, Lindholt JS, Johnsen SP, Zhang JY, Cheng X, Huang X, Daugherty A, Levy BD, Libby P, Shi GP. Allergic Lung Inflammation Aggravates Angiotensin II-Induced Abdominal Aortic Aneurysms in Mice. Arterioscler Thromb Vasc Biol. 2016 Jan; 36(1):69-77.
    View in: PubMed
    Score: 0.176
  17. Zhou Y, Yu X, Chen H, Sjöberg S, Roux J, Zhang L, Ivoulsou AH, Bensaid F, Liu CL, Liu J, Tordjman J, Clement K, Lee CH, Hotamisligil GS, Libby P, Shi GP. Leptin Deficiency Shifts Mast Cells toward Anti-Inflammatory Actions and Protects Mice from Obesity and Diabetes by Polarizing M2 Macrophages. Cell Metab. 2015 Dec 01; 22(6):1045-58.
    View in: PubMed
    Score: 0.176
  18. Lee YJ, Liu C, Liao M, Sukhova GK, Shirakawa J, Abdennour M, Iamarene K, Andre S, Inouye K, Clement K, Kulkarni RN, Banks AS, Libby P, Shi GP. Deficiency of Fc?R1 Increases Body Weight Gain but Improves Glucose Tolerance in Diet-Induced Obese Mice. Endocrinology. 2015 Nov; 156(11):4047-58.
    View in: PubMed
    Score: 0.174
  19. Wang J, Sun C, Gerdes N, Liu C, Liao M, Liu J, Shi MA, He A, Zhou Y, Sukhova GK, Chen H, Cheng XW, Kuzuya M, Murohara T, Zhang J, Cheng X, Jiang M, Shull GE, Rogers S, Yang CL, Ke Q, Jelen S, Bindels R, Ellison DH, Jarolim P, Libby P, Shi GP. Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter. Nat Med. 2015 Jul; 21(7):820-6.
    View in: PubMed
    Score: 0.172
  20. Zhou Y, Wu W, Lindholt JS, Sukhova GK, Libby P, Yu X, Shi GP. Regulatory T cells in human and angiotensin II-induced mouse abdominal aortic aneurysms. Cardiovasc Res. 2015 Jul 01; 107(1):98-107.
    View in: PubMed
    Score: 0.169
  21. Wang J, Sjöberg S, Tang TT, Oörni K, Wu W, Liu C, Secco B, Tia V, Sukhova GK, Fernandes C, Lesner A, Kovanen PT, Libby P, Cheng X, Shi GP. Cathepsin G activity lowers plasma LDL and reduces atherosclerosis. Biochim Biophys Acta. 2014 Nov; 1842(11):2174-83.
    View in: PubMed
    Score: 0.161
  22. Wang J, Sukhova GK, Liu J, Ozaki K, Lesner A, Libby P, Kovanen PT, Shi GP. Cathepsin G deficiency reduces periaortic calcium chloride injury-induced abdominal aortic aneurysms in mice. J Vasc Surg. 2015 Dec; 62(6):1615-24.
    View in: PubMed
    Score: 0.161
  23. Wang J, Lindholt JS, Sukhova GK, Shi MA, Xia M, Chen H, Xiang M, He A, Wang Y, Xiong N, Libby P, Wang JA, Shi GP. IgE actions on CD4+ T cells, mast cells, and macrophages participate in the pathogenesis of experimental abdominal aortic aneurysms. EMBO Mol Med. 2014 Jul; 6(7):952-69.
    View in: PubMed
    Score: 0.160
  24. Chen H, Wang J, Xiang MX, Lin Y, He A, Jin CN, Guan J, Sukhova GK, Libby P, Wang JA, Shi GP. Cathepsin S-mediated fibroblast trans-differentiation contributes to left ventricular remodelling after myocardial infarction. Cardiovasc Res. 2013 Oct 01; 100(1):84-94.
    View in: PubMed
    Score: 0.149
  25. Cheng X, Wang J, Xia N, Yan XX, Tang TT, Chen H, Zhang HJ, Liu J, Kong W, Sjöberg S, Folco E, Libby P, Liao YH, Shi GP. A guanidine-rich regulatory oligodeoxynucleotide improves type-2 diabetes in obese mice by blocking T-cell differentiation. EMBO Mol Med. 2012 Oct; 4(10):1112-25.
    View in: PubMed
    Score: 0.142
  26. Sun J, Sukhova GK, Zhang J, Chen H, Sjöberg S, Libby P, Xiang M, Wang J, Peters C, Reinheckel T, Shi GP. Cathepsin L activity is essential to elastase perfusion-induced abdominal aortic aneurysms in mice. Arterioscler Thromb Vasc Biol. 2011 Nov; 31(11):2500-8.
    View in: PubMed
    Score: 0.133
  27. Wang J, Cheng X, Xiang MX, Alanne-Kinnunen M, Wang JA, Chen H, He A, Sun X, Lin Y, Tang TT, Tu X, Sjöberg S, Sukhova GK, Liao YH, Conrad DH, Yu L, Kawakami T, Kovanen PT, Libby P, Shi GP. IgE stimulates human and mouse arterial cell apoptosis and cytokine expression and promotes atherogenesis in Apoe-/- mice. J Clin Invest. 2011 Sep; 121(9):3564-77.
    View in: PubMed
    Score: 0.131
  28. Sun J, Sukhova GK, Zhang J, Chen H, Sjöberg S, Libby P, Xia M, Xiong N, Gelb BD, Shi GP. Cathepsin K deficiency reduces elastase perfusion-induced abdominal aortic aneurysms in mice. Arterioscler Thromb Vasc Biol. 2012 Jan; 32(1):15-23.
    View in: PubMed
    Score: 0.131
  29. Zhang J, Sun J, Lindholt JS, Sukhova GK, Sinnamon M, Stevens RL, Adachi R, Libby P, Thompson RW, Shi GP. Mast cell tryptase deficiency attenuates mouse abdominal aortic aneurysm formation. Circ Res. 2011 May 27; 108(11):1316-27.
    View in: PubMed
    Score: 0.128
  30. Tang EH, Shvartz E, Shimizu K, Rocha VZ, Zheng C, Fukuda D, Shi GP, Sukhova G, Libby P. Deletion of EP4 on bone marrow-derived cells enhances inflammation and angiotensin II-induced abdominal aortic aneurysm formation. Arterioscler Thromb Vasc Biol. 2011 Feb; 31(2):261-9.
    View in: PubMed
    Score: 0.125
  31. Tang EH, Shimizu K, Christen T, Rocha VZ, Shvartz E, Tesmenitsky Y, Sukhova G, Shi GP, Libby P. Lack of EP4 receptors on bone marrow-derived cells enhances inflammation in atherosclerotic lesions. Cardiovasc Res. 2011 Jan 01; 89(1):234-43.
    View in: PubMed
    Score: 0.123
  32. Sun J, Hartvigsen K, Chou MY, Zhang Y, Sukhova GK, Zhang J, Lopez-Ilasaca M, Diehl CJ, Yakov N, Harats D, George J, Witztum JL, Libby P, Ploegh H, Shi GP. Deficiency of antigen-presenting cell invariant chain reduces atherosclerosis in mice. Circulation. 2010 Aug 24; 122(8):808-20.
    View in: PubMed
    Score: 0.122
  33. Sun J, Zhang J, Lindholt JS, Sukhova GK, Liu J, He A, Abrink M, Pejler G, Stevens RL, Thompson RW, Ennis TL, Gurish MF, Libby P, Shi GP. Critical role of mast cell chymase in mouse abdominal aortic aneurysm formation. Circulation. 2009 Sep 15; 120(11):973-82.
    View in: PubMed
    Score: 0.115
  34. Liu J, Divoux A, Sun J, Zhang J, Clément K, Glickman JN, Sukhova GK, Wolters PJ, Du J, Gorgun CZ, Doria A, Libby P, Blumberg RS, Kahn BB, Hotamisligil GS, Shi GP. Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice. Nat Med. 2009 Aug; 15(8):940-5.
    View in: PubMed
    Score: 0.114
  35. Schneider F, Sukhova GK, Aikawa M, Canner J, Gerdes N, Tang SM, Shi GP, Apte SS, Libby P. Matrix-metalloproteinase-14 deficiency in bone-marrow-derived cells promotes collagen accumulation in mouse atherosclerotic plaques. Circulation. 2008 Feb 19; 117(7):931-9.
    View in: PubMed
    Score: 0.103
  36. Sun J, Sukhova GK, Yang M, Wolters PJ, MacFarlane LA, Libby P, Sun C, Zhang Y, Liu J, Ennis TL, Knispel R, Xiong W, Thompson RW, Baxter BT, Shi GP. Mast cells modulate the pathogenesis of elastase-induced abdominal aortic aneurysms in mice. J Clin Invest. 2007 Nov; 117(11):3359-68.
    View in: PubMed
    Score: 0.101
  37. Yang M, Zhang Y, Pan J, Sun J, Liu J, Libby P, Sukhova GK, Doria A, Katunuma N, Peroni OD, Guerre-Millo M, Kahn BB, Clement K, Shi GP. Cathepsin L activity controls adipogenesis and glucose tolerance. Nat Cell Biol. 2007 Aug; 9(8):970-7.
    View in: PubMed
    Score: 0.099
  38. Sun J, Sukhova GK, Wolters PJ, Yang M, Kitamoto S, Libby P, MacFarlane LA, Mallen-St Clair J, Shi GP. Mast cells promote atherosclerosis by releasing proinflammatory cytokines. Nat Med. 2007 Jun; 13(6):719-24.
    View in: PubMed
    Score: 0.098
  39. Kitamoto S, Sukhova GK, Sun J, Yang M, Libby P, Love V, Duramad P, Sun C, Zhang Y, Yang X, Peters C, Shi GP. Cathepsin L deficiency reduces diet-induced atherosclerosis in low-density lipoprotein receptor-knockout mice. Circulation. 2007 Apr 17; 115(15):2065-75.
    View in: PubMed
    Score: 0.097
  40. Liu J, Sukhova GK, Yang JT, Sun J, Ma L, Ren A, Xu WH, Fu H, Dolganov GM, Hu C, Libby P, Shi GP. Cathepsin L expression and regulation in human abdominal aortic aneurysm, atherosclerosis, and vascular cells. Atherosclerosis. 2006 Feb; 184(2):302-11.
    View in: PubMed
    Score: 0.086
  41. Sukhova GK, Wang B, Libby P, Pan JH, Zhang Y, Grubb A, Fang K, Chapman HA, Shi GP. Cystatin C deficiency increases elastic lamina degradation and aortic dilatation in apolipoprotein E-null mice. Circ Res. 2005 Feb 18; 96(3):368-75.
    View in: PubMed
    Score: 0.083
  42. Pan JH, Sukhova GK, Yang JT, Wang B, Xie T, Fu H, Zhang Y, Satoskar AR, David JR, Metz CN, Bucala R, Fang K, Simon DI, Chapman HA, Libby P, Shi GP. Macrophage migration inhibitory factor deficiency impairs atherosclerosis in low-density lipoprotein receptor-deficient mice. Circulation. 2004 Jun 29; 109(25):3149-53.
    View in: PubMed
    Score: 0.080
  43. Liu J, Sukhova GK, Sun JS, Xu WH, Libby P, Shi GP. Lysosomal cysteine proteases in atherosclerosis. Arterioscler Thromb Vasc Biol. 2004 Aug; 24(8):1359-66.
    View in: PubMed
    Score: 0.080
  44. Pan JH, Lindholt JS, Sukhova GK, Baugh JA, Henneberg EW, Bucala R, Donnelly SC, Libby P, Metz C, Shi GP. Macrophage migration inhibitory factor is associated with aneurysmal expansion. J Vasc Surg. 2003 Mar; 37(3):628-35.
    View in: PubMed
    Score: 0.073
  45. Sukhova GK, Zhang Y, Pan JH, Wada Y, Yamamoto T, Naito M, Kodama T, Tsimikas S, Witztum JL, Lu ML, Sakara Y, Chin MT, Libby P, Shi GP. Deficiency of cathepsin S reduces atherosclerosis in LDL receptor-deficient mice. J Clin Invest. 2003 Mar; 111(6):897-906.
    View in: PubMed
    Score: 0.073
  46. Wang Y, Liu CL, Fang W, Zhang X, Yang C, Li J, Liu J, Sukhova GK, Gurish MF, Libby P, Shi GP, Zhang J. Deficiency of mouse mast cell protease 4 mitigates cardiac dysfunctions in mice after myocardium infarction. Biochim Biophys Acta Mol Basis Dis. 2019 06 01; 1865(6):1170-1181.
    View in: PubMed
    Score: 0.055
  47. Koskinas KC, Sukhova GK, Baker AB, Papafaklis MI, Chatzizisis YS, Coskun AU, Quillard T, Jonas M, Maynard C, Antoniadis AP, Shi GP, Libby P, Edelman ER, Feldman CL, Stone PH. Thin-capped atheromata with reduced collagen content in pigs develop in coronary arterial regions exposed to persistently low endothelial shear stress. Arterioscler Thromb Vasc Biol. 2013 Jul; 33(7):1494-504.
    View in: PubMed
    Score: 0.037
  48. Chatzizisis YS, Baker AB, Sukhova GK, Koskinas KC, Papafaklis MI, Beigel R, Jonas M, Coskun AU, Stone BV, Maynard C, Shi GP, Libby P, Feldman CL, Edelman ER, Stone PH. Augmented expression and activity of extracellular matrix-degrading enzymes in regions of low endothelial shear stress colocalize with coronary atheromata with thin fibrous caps in pigs. Circulation. 2011 Feb 15; 123(6):621-30.
    View in: PubMed
    Score: 0.032
  49. Schulte S, Sun J, Libby P, Macfarlane L, Sun C, Lopez-Ilasaca M, Shi GP, Sukhova GK. Cystatin C deficiency promotes inflammation in angiotensin II-induced abdominal aortic aneurisms in atherosclerotic mice. Am J Pathol. 2010 Jul; 177(1):456-63.
    View in: PubMed
    Score: 0.030
  50. Aikawa E, Aikawa M, Libby P, Figueiredo JL, Rusanescu G, Iwamoto Y, Fukuda D, Kohler RH, Shi GP, Jaffer FA, Weissleder R. Arterial and aortic valve calcification abolished by elastolytic cathepsin S deficiency in chronic renal disease. Circulation. 2009 Apr 07; 119(13):1785-94.
    View in: PubMed
    Score: 0.028
  51. Jaffer FA, Kim DE, Quinti L, Tung CH, Aikawa E, Pande AN, Kohler RH, Shi GP, Libby P, Weissleder R. Optical visualization of cathepsin K activity in atherosclerosis with a novel, protease-activatable fluorescence sensor. Circulation. 2007 May 01; 115(17):2292-8.
    View in: PubMed
    Score: 0.024
Connection Strength
The connection strength for co-authors is the sum of the scores for each of their shared publications.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.