Harvard Catalyst Profiles

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Mihaela G Gadjeva, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01EY022054 (GADJEVA, MIHAELA GUEORGUIEVA) Aug 1, 2012 - Jul 31, 2021
    Novel treatment strategies to regulate inflammation during P.aeruginosa keratitis
    Role: Principal Investigator
  2. R21EY019944 (GADJEVA, MIHAELA GUEORGUIEVA) Jan 1, 2010 - Jun 30, 2012
    Inhibition of MIF is protective against Pseudomonas aeruginosa-eye infection
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Kugadas A, Geddes-McAlister J, Guy E, DiGiandomenico A, Sykes DB, Mansour MK, Mirchev R, Gadjeva M. Frontline Science: Employing enzymatic treatment options for management of ocular biofilm-based infections. J Leukoc Biol. 2019 Jan 28. PMID: 30690787.
    Citations:    Fields:    
  2. Christiansen SH, Murphy RA, Juul-Madsen K, Fredborg M, Hvam ML, Axelgaard E, Skovdal SM, Meyer RL, Sørensen UBS, Möller A, Nyengaard JR, Nørskov-Lauritsen N, Wang M, Gadjeva M, Howard KA, Davies JC, Petersen E, Vorup-Jensen T. The Immunomodulatory Drug Glatiramer Acetate is Also an Effective Antimicrobial Agent that Kills Gram-negative Bacteria. Sci Rep. 2017 Nov 15; 7(1):15653. PMID: 29142299.
    Citations:    Fields:    
  3. Kugadas A, Wright Q, Geddes-McAlister J, Gadjeva M. Role of Microbiota in Strengthening Ocular Mucosal Barrier Function Through Secretory IgA. Invest Ophthalmol Vis Sci. 2017 09 01; 58(11):4593-4600. PMID: 28892827.
    Citations: 1     Fields:    Translation:AnimalsCells
  4. St Leger AJ, Desai JV, Drummond RA, Kugadas A, Almaghrabi F, Silver P, Raychaudhuri K, Gadjeva M, Iwakura Y, Lionakis MS, Caspi RR. An Ocular Commensal Protects against Corneal Infection by Driving an Interleukin-17 Response from Mucosal ?d T Cells. Immunity. 2017 07 18; 47(1):148-158.e5. PMID: 28709803.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  5. Roux D, Weatherholt M, Clark B, Gadjeva M, Renaud D, Scott D, Skurnik D, Priebe GP, Pier G, Gerard C, Yoder-Himes DR. Immune Recognition of the Epidemic Cystic Fibrosis Pathogen Burkholderia dolosa. Infect Immun. 2017 06; 85(6). PMID: 28348057.
    Citations: 1     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  6. Pandya HJ, Kanakasabapathy MK, Verma S, Chug MK, Memic A, Gadjeva M, Shafiee H. Label-free electrical sensing of bacteria in eye wash samples: A step towards point-of-care detection of pathogens in patients with infectious keratitis. Biosens Bioelectron. 2017 May 15; 91:32-39. PMID: 27987408.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  7. Kugadas A, Christiansen SH, Sankaranarayanan S, Surana NK, Gauguet S, Kunz R, Fichorova R, Vorup-Jensen T, Gadjeva M. Impact of Microbiota on Resistance to Ocular Pseudomonas aeruginosa-Induced Keratitis. PLoS Pathog. 2016 Sep; 12(9):e1005855. PMID: 27658245.
    Citations: 10     Fields:    
  8. Kugadas A, Gadjeva M. Impact of Microbiome on Ocular Health. Ocul Surf. 2016 07; 14(3):342-9. PMID: 27189865.
    Citations: 12     Fields:    Translation:Humans
  9. Gauguet S, D'Ortona S, Ahnger-Pier K, Duan B, Surana NK, Lu R, Cywes-Bentley C, Gadjeva M, Shan Q, Priebe GP, Pier GB. Intestinal Microbiota of Mice Influences Resistance to Staphylococcus aureus Pneumonia. Infect Immun. 2015 Oct; 83(10):4003-14. PMID: 26216419; PMCID: PMC4567647.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  10. Terzulli M, Contreras-Ruiz L, Ruiz LC, Kugadas A, Masli S, Gadjeva M. TSP-1 Deficiency Alters Ocular Microbiota: Implications for Sjögren's Syndrome Pathogenesis. J Ocul Pharmacol Ther. 2015 Sep; 31(7):413-8. PMID: 26352162; PMCID: PMC4575514.
    Citations: 3     Fields:    Translation:AnimalsCells
  11. Chen L, Zhou X, Fan LX, Yao Y, Swenson-Fields KI, Gadjeva M, Wallace DP, Peters DJ, Yu A, Grantham JJ, Li X. Macrophage migration inhibitory factor promotes cyst growth in polycystic kidney disease. J Clin Invest. 2015 Jun; 125(6):2399-412. PMID: 25961459; PMCID: PMC4497763.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  12. Rahman S, Gadjeva M. Does NETosis Contribute to the Bacterial Pathoadaptation in Cystic Fibrosis? Front Immunol. 2014; 5:378. PMID: 25157250; PMCID: PMC4127480.
    Citations: 14     
  13. Shan Q, Dwyer M, Rahman S, Gadjeva M. Distinct susceptibilities of corneal Pseudomonas aeruginosa clinical isolates to neutrophil extracellular trap-mediated immunity. Infect Immun. 2014 Oct; 82(10):4135-43. PMID: 25047845; PMCID: PMC4187885.
    Citations: 10     Fields:    Translation:AnimalsCells
  14. Dwyer M, Shan Q, D'Ortona S, Maurer R, Mitchell R, Olesen H, Thiel S, Huebner J, Gadjeva M. Cystic fibrosis sputum DNA has NETosis characteristics and neutrophil extracellular trap release is regulated by macrophage migration-inhibitory factor. J Innate Immun. 2014; 6(6):765-79. PMID: 24862346; PMCID: PMC4201867.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  15. Dwyer M, Gadjeva M. Opsonophagocytic assay. Methods Mol Biol. 2014; 1100:373-9. PMID: 24218277.
    Citations: 1     Fields:    Translation:HumansCells
  16. Gadjeva M. The complement system. Overview. Methods Mol Biol. 2014; 1100:1-9. PMID: 24218246.
    Citations: 7     Fields:    Translation:HumansAnimals
  17. Py BF, Gonzalez SF, Long K, Kim MS, Kim YA, Zhu H, Yao J, Degauque N, Villet R, Ymele-Leki P, Gadjeva M, Pier GB, Carroll MC, Yuan J. Cochlin produced by follicular dendritic cells promotes antibacterial innate immunity. Immunity. 2013 May 23; 38(5):1063-72. PMID: 23684986; PMCID: PMC3758559.
    Citations: 10     Fields:    Translation:AnimalsCells
  18. Reidy T, Rittenberg A, Dwyer M, D'Ortona S, Pier G, Gadjeva M. Homotrimeric macrophage migration inhibitory factor (MIF) drives inflammatory responses in the corneal epithelium by promoting caveolin-rich platform assembly in response to infection. J Biol Chem. 2013 Mar 22; 288(12):8269-78. PMID: 23372160; PMCID: PMC3605645.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  19. Zaidi T, Reidy T, D'Ortona S, Fichorova R, Pier G, Gadjeva M. CD74 deficiency ameliorates Pseudomonas aeruginosa-induced ocular infection. Sci Rep. 2011; 1:58. PMID: 22355577; PMCID: PMC3216545.
    Citations: 3     Fields:    Translation:AnimalsCells
  20. Skurnik D, Merighi M, Grout M, Gadjeva M, Maira-Litran T, Ericsson M, Goldmann DA, Huang SS, Datta R, Lee JC, Pier GB. Animal and human antibodies to distinct Staphylococcus aureus antigens mutually neutralize opsonic killing and protection in mice. J Clin Invest. 2010 Sep; 120(9):3220-33. PMID: 20739753; PMCID: PMC2929724.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  21. Kojouharova M, Reid K, Gadjeva M. New insights into the molecular mechanisms of classical complement activation. Mol Immunol. 2010 Aug; 47(13):2154-60. PMID: 20542571.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  22. Gadjeva M, Nagashima J, Zaidi T, Mitchell RA, Pier GB. Inhibition of macrophage migration inhibitory factor ameliorates ocular Pseudomonas aeruginosa-induced keratitis. PLoS Pathog. 2010 Mar 26; 6(3):e1000826. PMID: 20361053; PMCID: PMC2845658.
    Citations: 18     Fields:    Translation:AnimalsCells
  23. Kamei A, Koh AY, Gadjeva M, Priebe GP, Lory S, Pier GB. Analysis of acquisition of Pseudomonas aeruginosa gastrointestinal mucosal colonization and horizontal transmission in a murine model. J Infect Dis. 2010 Jan 01; 201(1):71-80. PMID: 19938976; PMCID: PMC2791183.
    Citations: 1     Fields:    Translation:AnimalsCells
  24. Gadjeva M, Paradis-Bleau C, Priebe GP, Fichorova R, Pier GB. Caveolin-1 modifies the immunity to Pseudomonas aeruginosa. J Immunol. 2010 Jan 01; 184(1):296-302. PMID: 19949109; PMCID: PMC2900931.
    Citations: 20     Fields:    Translation:AnimalsCells
  25. Ruseva M, Kolev M, Dagnaes-Hansen F, Hansen SB, Takahashi K, Ezekowitz A, Thiel S, Jensenius JC, Gadjeva M. Mannan-binding lectin deficiency modulates the humoral immune response dependent on the genetic environment. Immunology. 2009 Jun; 127(2):279-88. PMID: 19476514; PMCID: PMC2691793.
    Citations: 12     Fields:    Translation:AnimalsPHPublic Health
  26. Bajmoczi M, Gadjeva M, Alper SL, Pier GB, Golan DE. Cystic fibrosis transmembrane conductance regulator and caveolin-1 regulate epithelial cell internalization of Pseudomonas aeruginosa. Am J Physiol Cell Physiol. 2009 Aug; 297(2):C263-77. PMID: 19386787; PMCID: PMC2724095.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  27. Thiel S, Gadjeva M. Humoral pattern recognition molecules: mannan-binding lectin and ficolins. Adv Exp Med Biol. 2009; 653:58-73. PMID: 19799112.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  28. Gadjeva MG, Rouseva MM, Zlatarova AS, Reid KB, Kishore U, Kojouharova MS. Interaction of human C1q with IgG and IgM: revisited. Biochemistry. 2008 Dec 09; 47(49):13093-102. PMID: 19006321.
    Citations: 17     Fields:    Translation:HumansCells
  29. Roumenina LT, Popov KT, Bureeva SV, Kojouharova M, Gadjeva M, Rabheru S, Thakrar R, Kaplun A, Kishore U. Interaction of the globular domain of human C1q with Salmonella typhimurium lipopolysaccharide. Biochim Biophys Acta. 2008 Sep; 1784(9):1271-6. PMID: 18513495.
    Citations: 7     Fields:    Translation:HumansCells
  30. Campodónico VL, Gadjeva M, Paradis-Bleau C, Uluer A, Pier GB. Airway epithelial control of Pseudomonas aeruginosa infection in cystic fibrosis. Trends Mol Med. 2008 Mar; 14(3):120-33. PMID: 18262467; PMCID: PMC3697050.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  31. Gadjeva M, Wang Y, Horwitz BH. NF-kappaB p50 and p65 subunits control intestinal homeostasis. Eur J Immunol. 2007 Sep; 37(9):2509-17. PMID: 17705134.
    Citations: 7     Fields:    Translation:Animals
  32. Østergaard J, Thiel S, Gadjeva M, Hansen TK, Rasch R, Flyvbjerg A. Mannose-binding lectin deficiency attenuates renal changes in a streptozotocin-induced model of type 1 diabetes in mice. Diabetologia. 2007 Jul; 50(7):1541-9. PMID: 17473913.
    Citations: 18     Fields:    Translation:Animals
  33. S. Thiel and M. Gadjeva. Humoral pattern recognition molecules: MBL and Ficolins. Target Pattern Recognition in Innate Immunity. 2007.
  34. Thiel S, Steffensen R, Christensen IJ, Ip WK, Lau YL, Reason IJ, Eiberg H, Gadjeva M, Ruseva M, Jensenius JC. Deficiency of mannan-binding lectin associated serine protease-2 due to missense polymorphisms. Genes Immun. 2007 Mar; 8(2):154-63. PMID: 17252003.
    Citations: 18     Fields:    Translation:Humans
  35. Ghai R, Waters P, Roumenina LT, Gadjeva M, Kojouharova MS, Reid KB, Sim RB, Kishore U. C1q and its growing family. Immunobiology. 2007; 212(4-5):253-66. PMID: 17544811.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  36. Zlatarova AS, Rouseva M, Roumenina LT, Gadjeva M, Kolev M, Dobrev I, Olova N, Ghai R, Jensenius JC, Reid KB, Kishore U, Kojouharova MS. Existence of different but overlapping IgG- and IgM-binding sites on the globular domain of human C1q. Biochemistry. 2006 Aug 22; 45(33):9979-88. PMID: 16906756.
    Citations: 9     Fields:    Translation:HumansCells
  37. Roumenina LT, Ruseva MM, Zlatarova A, Ghai R, Kolev M, Olova N, Gadjeva M, Agrawal A, Bottazzi B, Mantovani A, Reid KB, Kishore U, Kojouharova MS. Interaction of C1q with IgG1, C-reactive protein and pentraxin 3: mutational studies using recombinant globular head modules of human C1q A, B, and C chains. Biochemistry. 2006 Apr 04; 45(13):4093-104. PMID: 16566583; PMCID: PMC3874390.
    Citations: 37     Fields:    Translation:HumansCells
  38. Tomczak MF, Gadjeva M, Wang YY, Brown K, Maroulakou I, Tsichlis PN, Erdman SE, Fox JG, Horwitz BH. Defective activation of ERK in macrophages lacking the p50/p105 subunit of NF-kappaB is responsible for elevated expression of IL-12 p40 observed after challenge with Helicobacter hepaticus. J Immunol. 2006 Jan 15; 176(2):1244-51. PMID: 16394015.
    Citations: 16     Fields:    Translation:AnimalsCells
  39. Roumenina LT, Kantardjiev AA, Atanasov BP, Waters P, Gadjeva M, Reid KB, Mantovani A, Kishore U, Kojouharova MS. Role of Ca2+ in the electrostatic stability and the functional activity of the globular domain of human C1q. Biochemistry. 2005 Nov 01; 44(43):14097-109. PMID: 16245926.
    Citations: 12     Fields:    Translation:HumansCells
  40. Møller-Kristensen M, Wang W, Ruseva M, Thiel S, Nielsen S, Takahashi K, Shi L, Ezekowitz A, Jensenius JC, Gadjeva M. Mannan-binding lectin recognizes structures on ischaemic reperfused mouse kidneys and is implicated in tissue injury. Scand J Immunol. 2005 May; 61(5):426-34. PMID: 15882434.
    Citations: 50     Fields:    Translation:Animals
  41. S. Thiel and M. Gadjeva. Assays for Mannan Binding Lectin Pathway. Manual for Molecular and Clinical Laboratory Immunology. 2005.
  42. Gadjeva M, Paludan SR, Thiel S, Slavov V, Ruseva M, Eriksson K, Löwhagen GB, Shi L, Takahashi K, Ezekowitz A, Jensenius JC. Mannan-binding lectin modulates the response to HSV-2 infection. Clin Exp Immunol. 2004 Nov; 138(2):304-11. PMID: 15498041; PMCID: PMC1809223.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  43. Gadjeva M, Tomczak MF, Zhang M, Wang YY, Dull K, Rogers AB, Erdman SE, Fox JG, Carroll M, Horwitz BH. A role for NF-kappa B subunits p50 and p65 in the inhibition of lipopolysaccharide-induced shock. J Immunol. 2004 Nov 01; 173(9):5786-93. PMID: 15494531.
    Citations: 29     Fields:    Translation:AnimalsCells
  44. Kishore U, Ghai R, Greenhough TJ, Shrive AK, Bonifati DM, Gadjeva MG, Waters P, Kojouharova MS, Chakraborty T, Agrawal A. Structural and functional anatomy of the globular domain of complement protein C1q. Immunol Lett. 2004 Sep; 95(2):113-28. PMID: 15388251; PMCID: PMC3818097.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  45. Gadjeva M, Takahashi K, Thiel S. Mannan-binding lectin--a soluble pattern recognition molecule. Mol Immunol. 2004 Jun; 41(2-3):113-21. PMID: 15159056.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  46. Kojouharova MS, Gadjeva MG, Tsacheva IG, Zlatarova A, Roumenina LT, Tchorbadjieva MI, Atanasov BP, Waters P, Urban BC, Sim RB, Reid KB, Kishore U. Mutational analyses of the recombinant globular regions of human C1q A, B, and C chains suggest an essential role for arginine and histidine residues in the C1q-IgG interaction. J Immunol. 2004 Apr 01; 172(7):4351-8. PMID: 15034050.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  47. Gadjeva M, Thiel S, Jensenius JC. Assays for the mannan-binding lectin pathway. Curr Protoc Immunol. 2004 Feb; Chapter 13:Unit 13.6. PMID: 18432925.
    Citations: 4     Fields:    Translation:Humans
  48. Verschoor A, Brockman MA, Gadjeva M, Knipe DM, Carroll MC. Myeloid C3 determines induction of humoral responses to peripheral herpes simplex virus infection. J Immunol. 2003 Nov 15; 171(10):5363-71. PMID: 14607939.
    Citations: 27     Fields:    Translation:AnimalsCells
  49. Stengaard-Pedersen K, Thiel S, Gadjeva M, Møller-Kristensen M, Sørensen R, Jensen LT, Sjøholm AG, Fugger L, Jensenius JC. Inherited deficiency of mannan-binding lectin-associated serine protease 2. N Engl J Med. 2003 Aug 07; 349(6):554-60. PMID: 12904520.
    Citations: 47     Fields:    Translation:HumansCells
  50. M. Gadjeva, S. Thiel, and J. C. Jensenius. Assays for Mannan Binding Lectin Pathway. Current Protocols in Immunology. 2003.
  51. Gadjeva M, Verschoor A, Brockman MA, Jezak H, Shen LM, Knipe DM, Carroll MC. Macrophage-derived complement component C4 can restore humoral immunity in C4-deficient mice. J Immunol. 2002 Nov 15; 169(10):5489-95. PMID: 12421924.
    Citations: 15     Fields:    Translation:AnimalsCells
  52. M. Gadjeva, A. Verschoor and M. Carroll. The role of complement in innate and adaptive immunity. Infectious Diseases: Innate Immunity. 2002; p305-319.
  53. Gadjeva M, Thiel S, Jensenius JC. The mannan-binding-lectin pathway of the innate immune response. Curr Opin Immunol. 2001 Feb; 13(1):74-8. PMID: 11154921.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  54. Gadjeva M. The covalent binding reaction of complement component C3. 1999.
  55. Gadjeva M, Dodds AW, Taniguchi-Sidle A, Willis AC, Isenman DE, Law SK. The covalent binding reaction of complement component C3. J Immunol. 1998 Jul 15; 161(2):985-90. PMID: 9670979.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.