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Peter The Sage, Ph.D.

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Research
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  1. K22AI132937 (SAGE, PETER THE) Jul 1, 2018 - Jun 30, 2020
    NIH/NIAID
    Control of antibody responses in vaccination and allergic inflammation by follicular regulatory T cells
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Janssen E, Tohme M, Butts J, Giguere SS, Sage PT, Velázquez FE, Kam C, Milin E, Das M, Sobh A, Al-Tamemi S, Luscinskas FW, Batista F, Geha RS. DOCK8 is essential for LFA-1 dependent positioning of T follicular helper cells in germinal centers. JCI Insight. 2020 Jun 23. PMID: 32573493.
    Citations:    
  2. Shi Q, Carman CV, Chen Y, Sage PT, Xue F, Liang XM, Gilbert GE. Unexpected enhancement of FVIII immunogenicity by endothelial expression in lentivirus-transduced and transgenic mice. Blood Adv. 2020 May 26; 4(10):2272-2285. PMID: 32453842.
    Citations:    
  3. Morrissette JA, Pruner K, Lee S, Paster J, Sommer W, O J, Hanekamp I, Sage P, Benichou G, Madsen JC. Characterization of a Novel CD8+ B Cell Subset in Monkeys Tolerant of Heart Allografts. J Heart Lung Transplant. 2020 Apr; 39(4S):S89. PMID: 32466057.
    Citations:    
  4. Mohammed MT, Sage PT. Follicular T-cell regulation of alloantibody formation. Curr Opin Organ Transplant. 2020 Feb; 25(1):22-26. PMID: 31789953.
    Citations:    
  5. Clement RL, Daccache J, Mohammed MT, Diallo A, Blazar BR, Kuchroo VK, Lovitch SB, Sharpe AH, Sage PT. Follicular regulatory T cells control humoral and allergic immunity by restraining early B cell responses. Nat Immunol. 2019 10; 20(10):1360-1371. PMID: 31477921.
    Citations:    
  6. Paz K, Flynn R, Du J, Tannheimer S, Johnson AJ, Dong S, Stark AK, Okkenhaug K, Panoskaltsis-Mortari A, Sage PT, Sharpe AH, Luznik L, Ritz J, Soiffer RJ, Cutler CS, Koreth J, Antin JH, Miklos DB, MacDonald KP, Hill GR, Maillard I, Serody JS, Murphy WJ, Munn DH, Feser C, Zaiken M, Vanhaesebroeck B, Turka LA, Byrd JC, Blazar BR. Targeting PI3Kd function for amelioration of murine chronic graft-versus-host disease. Am J Transplant. 2019 06; 19(6):1820-1830. PMID: 30748099.
    Citations:    
  7. Hou S, Clement RL, Diallo A, Blazar BR, Rudensky AY, Sharpe AH, Sage PT. FoxP3 and Ezh2 regulate Tfr cell suppressive function and transcriptional program. J Exp Med. 2019 03 04; 216(3):605-620. PMID: 30705058.
    Citations:    Fields:    
  8. Ron-Harel N, Notarangelo G, Ghergurovich JM, Paulo JA, Sage PT, Santos D, Satterstrom FK, Gygi SP, Rabinowitz JD, Sharpe AH, Haigis MC. Defective respiration and one-carbon metabolism contribute to impaired naïve T cell activation in aged mice. Proc Natl Acad Sci U S A. 2018 12 26; 115(52):13347-13352. PMID: 30530686.
    Citations:    Fields:    
  9. Ordikhani F, Uehara M, Kasinath V, Dai L, Eskandari SK, Bahmani B, Yonar M, Azzi JR, Haik Y, Sage PT, Murphy GF, Annabi N, Schatton T, Guleria I, Abdi R. Targeting antigen-presenting cells by anti-PD-1 nanoparticles augments antitumor immunity. JCI Insight. 2018 10 18; 3(20). PMID: 30333312.
    Citations:    Fields:    
  10. Paz K, Flynn R, Du J, Qi J, Luznik L, Maillard I, MacDonald KP, Hill GR, Serody JS, Murphy WJ, Sage PT, Sharpe AH, Miklos D, Cutler CS, Koreth J, Antin JH, Soiffer RJ, Ritz J, Bradner JE, Melnick AM, Blazar BR. Small-molecule BCL6 inhibitor effectively treats mice with nonsclerodermatous chronic graft-versus-host disease. Blood. 2019 01 03; 133(1):94-99. PMID: 30279226.
    Citations:    Fields:    
  11. Sage PT. Preventing Antibody-mediated Rejection During Transplantation: The Potential of Tfr Cells. Transplantation. 2018 10; 102(10):1597-1598. PMID: 29757906.
    Citations:    Fields:    
  12. Wedel J, Bruneau S, Liu K, Kong SW, Sage PT, Sabatini DM, Laplante M, Briscoe DM. DEPTOR modulates activation responses in CD4+ T cells and enhances immunoregulation following transplantation. Am J Transplant. 2019 01; 19(1):77-88. PMID: 29969188.
    Citations:    Fields:    
  13. Maarouf OH, Uehara M, Kasinath V, Solhjou Z, Banouni N, Bahmani B, Jiang L, Yilmam OA, Guleria I, Lovitch SB, Grogan JL, Fiorina P, Sage PT, Bromberg JS, McGrath MM, Abdi R. Repetitive ischemic injuries to the kidneys result in lymph node fibrosis and impaired healing. JCI Insight. 2018 07 12; 3(13). PMID: 29997302.
    Citations:    Fields:    
  14. Sage PT, Schildberg FA, Sobel RA, Kuchroo VK, Freeman GJ, Sharpe AH. Dendritic Cell PD-L1 Limits Autoimmunity and Follicular T Cell Differentiation and Function. J Immunol. 2018 04 15; 200(8):2592-2602. PMID: 29531164.
    Citations: 1     Fields:    
  15. Zhang R, Sage PT, Finn K, Huynh A, Blazar BR, Marangoni F, Mempel TR, Sharpe AH, Turka LA. Correction: B Cells Drive Autoimmunity in Mice with CD28-Deficient Regulatory T Cells. J Immunol. 2018 04 01; 200(7):2505-2506. PMID: 29475985.
    Citations:    Fields:    
  16. Zhang R, Sage PT, Finn K, Huynh A, Blazar BR, Marangoni F, Mempel TR, Sharpe AH, Turka LA. B Cells Drive Autoimmunity in Mice with CD28-Deficient Regulatory T Cells. J Immunol. 2017 12 15; 199(12):3972-3980. PMID: 29093061.
    Citations: 4     Fields:    Translation:AnimalsCells
  17. Sage PT, Ron-Harel N, Juneja VR, Sen DR, Maleri S, Sungnak W, Kuchroo VK, Haining WN, Chevrier N, Haigis M, Sharpe AH. Suppression by TFR cells leads to durable and selective inhibition of B cell effector function. Nat Immunol. 2016 Dec; 17(12):1436-1446. PMID: 27695002.
    Citations: 31     Fields:    Translation:AnimalsCells
  18. Ron-Harel N, Santos D, Ghergurovich JM, Sage PT, Reddy A, Lovitch SB, Dephoure N, Satterstrom FK, Sheffer M, Spinelli JB, Gygi S, Rabinowitz JD, Sharpe AH, Haigis MC. Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation. Cell Metab. 2016 07 12; 24(1):104-17. PMID: 27411012.
    Citations: 27     Fields:    Translation:AnimalsCells
  19. Sage PT, Sharpe AH. T follicular regulatory cells. Immunol Rev. 2016 May; 271(1):246-59. PMID: 27088919.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  20. Paterson AM, Lovitch SB, Sage PT, Juneja VR, Lee Y, Trombley JD, Arancibia-Cárcamo CV, Sobel RA, Rudensky AY, Kuchroo VK, Freeman GJ, Sharpe AH. Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity. J Exp Med. 2015 Sep 21; 212(10):1603-21. PMID: 26371185.
    Citations: 28     Fields:    Translation:AnimalsCells
  21. Sage PT, Tan CL, Freeman GJ, Haigis M, Sharpe AH. Defective TFH Cell Function and Increased TFR Cells Contribute to Defective Antibody Production in Aging. Cell Rep. 2015 Jul 14; 12(2):163-71. PMID: 26146074.
    Citations: 16     Fields:    Translation:AnimalsCells
  22. Sage PT, Sharpe AH. T follicular regulatory cells in the regulation of B cell responses. Trends Immunol. 2015 Jul; 36(7):410-8. PMID: 26091728.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  23. Wang N, Halibozek PJ, Yigit B, Zhao H, O'Keeffe MS, Sage P, Sharpe A, Terhorst C. Negative Regulation of Humoral Immunity Due to Interplay between the SLAMF1, SLAMF5, and SLAMF6 Receptors. Front Immunol. 2015; 6:158. PMID: 25926831.
    Citations: 6     
  24. Huynh A, DuPage M, Priyadharshini B, Sage PT, Quiros J, Borges CM, Townamchai N, Gerriets VA, Rathmell JC, Sharpe AH, Bluestone JA, Turka LA. Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability. Nat Immunol. 2015 Feb; 16(2):188-96. PMID: 25559257.
    Citations: 97     Fields:    Translation:AnimalsCells
  25. Sage PT, Sharpe AH. In vitro assay to sensitively measure T(FR) suppressive capacity and T(FH) stimulation of B cell responses. Methods Mol Biol. 2015; 1291:151-60. PMID: 25836309.
    Citations: 7     Fields:    Translation:AnimalsCellsPHPublic Health
  26. Sage PT, Paterson AM, Lovitch SB, Sharpe AH. The coinhibitory receptor CTLA-4 controls B cell responses by modulating T follicular helper, T follicular regulatory, and T regulatory cells. Immunity. 2014 Dec 18; 41(6):1026-39. PMID: 25526313.
    Citations: 79     Fields:    Translation:AnimalsCells
  27. Sage PT, Alvarez D, Godec J, von Andrian UH, Sharpe AH. Circulating T follicular regulatory and helper cells have memory-like properties. J Clin Invest. 2014 Dec; 124(12):5191-204. PMID: 25347469.
    Citations: 45     Fields:    Translation:AnimalsCells
  28. Cooper ZA, Juneja VR, Sage PT, Frederick DT, Piris A, Mitra D, Lo JA, Hodi FS, Freeman GJ, Bosenberg MW, McMahon M, Flaherty KT, Fisher DE, Sharpe AH, Wargo JA. Response to BRAF inhibition in melanoma is enhanced when combined with immune checkpoint blockade. Cancer Immunol Res. 2014 Jul; 2(7):643-54. PMID: 24903021.
    Citations: 56     Fields:    Translation:HumansAnimalsCells
  29. Martinelli R, Kamei M, Sage PT, Massol R, Varghese L, Sciuto T, Toporsian M, Dvorak AM, Kirchhausen T, Springer TA, Carman CV. Release of cellular tension signals self-restorative ventral lamellipodia to heal barrier micro-wounds. J Cell Biol. 2013 Apr 29; 201(3):449-65. PMID: 23629967.
    Citations: 27     Fields:    Translation:HumansCells
  30. Sage PT, Francisco LM, Carman CV, Sharpe AH. The receptor PD-1 controls follicular regulatory T cells in the lymph nodes and blood. Nat Immunol. 2013 Feb; 14(2):152-61. PMID: 23242415.
    Citations: 122     Fields:    Translation:AnimalsCells
  31. Sage PT, Varghese LM, Martinelli R, Sciuto TE, Kamei M, Dvorak AM, Springer TA, Sharpe AH, Carman CV. Antigen recognition is facilitated by invadosome-like protrusions formed by memory/effector T cells. J Immunol. 2012 Apr 15; 188(8):3686-99. PMID: 22442443.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  32. Jin Y, Chauhan SK, El Annan J, Annan JE, Sage PT, Sharpe AH, Dana R. A novel function for programmed death ligand-1 regulation of angiogenesis. Am J Pathol. 2011 04; 178(4):1922-9. PMID: 21435468.
    Citations: 17     Fields:    Translation:AnimalsCells
  33. Riella LV, Watanabe T, Sage PT, Yang J, Yeung M, Azzi J, Vanguri V, Chandraker A, Sharpe AH, Sayegh MH, Najafian N. Essential role of PDL1 expression on nonhematopoietic donor cells in acquired tolerance to vascularized cardiac allografts. Am J Transplant. 2011 Apr; 11(4):832-40. PMID: 21401869.
    Citations: 10     Fields:    Translation:AnimalsCells
  34. Koduru S, Kumar L, Massaad MJ, Ramesh N, Le Bras S, Ozcan E, Oyoshi MK, Kaku M, Fujiwara Y, Kremer L, King S, Fuhlbrigge R, Rodig S, Sage P, Carman C, Alcaide P, Luscinskas FW, Geha RS. Cdc42 interacting protein 4 (CIP4) is essential for integrin-dependent T-cell trafficking. Proc Natl Acad Sci U S A. 2010 Sep 14; 107(37):16252-6. PMID: 20805498.
    Citations: 12     Fields:    Translation:AnimalsCells
  35. Francisco LM, Sage PT, Sharpe AH. The PD-1 pathway in tolerance and autoimmunity. Immunol Rev. 2010 Jul; 236:219-42. PMID: 20636820.
    Citations: 421     Fields:    Translation:HumansAnimalsCells
  36. Sage PT, Carman CV. Settings and mechanisms for trans-cellular diapedesis. Front Biosci (Landmark Ed). 2009 Jun 01; 14:5066-83. PMID: 19482605.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  37. Bonasio R, Carman CV, Kim E, Sage PT, Love KR, Mempel TR, Springer TA, von Andrian UH. Specific and covalent labeling of a membrane protein with organic fluorochromes and quantum dots. Proc Natl Acad Sci U S A. 2007 Sep 11; 104(37):14753-8. PMID: 17785425.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  38. Carman CV, Sage PT, Sciuto TE, de la Fuente MA, Geha RS, Ochs HD, Dvorak HF, Dvorak AM, Springer TA. Transcellular diapedesis is initiated by invasive podosomes. Immunity. 2007 Jun; 26(6):784-97. PMID: 17570692.
    Citations: 166     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.