Harvard Catalyst Profiles

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Seemantini Nadkarni, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL142272 (NADKARNI, SEEMANTINI K) Aug 15, 2018 - Jun 30, 2022
    Integrated Coagulation Sensing to Predict Hemorrhage and Guide Transfusions
    Role: Principal Investigator
  2. R21EB023012 (NADKARNI, SEEMANTINI K) Jul 1, 2017 - Apr 30, 2021
    An Optical Sensor for Anticoagulation Self-Testing
    Role: Principal Investigator
  3. R01HL119867 (NADKARNI, SEEMANTINI K) Sep 1, 2014 - Jun 30, 2021
    Blood Coagulation Monitoring at the Point of Care
    Role: Principal Investigator
  4. R01HL119065 (NADKARNI, SEEMANTINI K) May 1, 2014 - Oct 31, 2020
    Intracoronary imaging of plaque collagen in patients
    Role: Co-Principal Investigator
  5. U54EB015408 (PARRISH, JOHN A) Jul 1, 2012 - May 31, 2023
    Point of Care Technology Research Center in Primary Care
    Role: Co-Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Lee H, Seeger MR, Lippok N, Nadkarni SK, van Soest G, Bouma BE. Nanosecond SRS fiber amplifier for label-free near-infrared photoacoustic microscopy of lipids. Photoacoustics. 2022 Mar; 25:100331. PMID: 35096525; PMCID: PMC8783138.
    Citations: 1     
  2. Ren J, Shishkov M, Villiger ML, Otsuka K, Nadkarni SK, Bouma BE. Single-catheter dual-modality intravascular imaging combining IVUS and OFDI: a holistic structural visualisation of coronary arteries. EuroIntervention. 2021 Dec 03; 17(11):e919-e922. PMID: 34219665; PMCID: PMC8649034.
    Citations:    Fields:    Translation:Humans
  3. Hajjarian Z, Brachtel EF, Tshikudi DM, Nadkarni SK. Mapping Mechanical Properties of the Tumor Microenvironment by Laser Speckle Rheological Microscopy. Cancer Res. 2021 09 15; 81(18):4874-4885. PMID: 34526347; PMCID: PMC8524785.
    Citations:    Fields:    Translation:Humans
  4. Hajjarian Z, Nadkarni SK. Technological perspectives on laser speckle micro-rheology for cancer mechanobiology research. J Biomed Opt. 2021 09; 26(9). PMID: 34549559.
    Citations:    Fields:    
  5. Tshikudi DM, Simandoux O, Kang D, Van Cott EM, Andrawes MN, Yelin D, Nadkarni SK. Imaging the dynamics and microstructure of fibrin clot polymerization in cardiac surgical patients using spectrally encoded confocal microscopy. Am J Hematol. 2021 08 01; 96(8):968-978. PMID: 33971046.
    Citations:    Fields:    Translation:Humans
  6. Hajjarian Z, Toussaint JD, Guerrero JL, Nadkarni SK. In-vivo mechanical characterization of coronary atherosclerotic plaques in living swine using intravascular laser speckle imaging. Biomed Opt Express. 2021 Apr 01; 12(4):2064-2078. PMID: 33996217.
    Citations: 2     
  7. Parada G, Yu Y, Riley W, Lojovich S, Tshikudi D, Ling Q, Zhang Y, Wang J, Ling L, Yang Y, Nadkarni S, Nabzdyk C, Zhao X. Ultrathin and Robust Hydrogel Coatings on Cardiovascular Medical Devices to Mitigate Thromboembolic and Infectious Complications. Adv Healthc Mater. 2020 10; 9(20):e2001116. PMID: 32940970.
    Citations: 4     Fields:    Translation:Animals
  8. Otsuka K, Villiger M, Nadkarni SK, Bouma BE. Intravascular Polarimetry: Clinical Translation and Future Applications of Catheter-Based Polarization Sensitive Optical Frequency Domain Imaging. Front Cardiovasc Med. 2020; 7:146. PMID: 33005632; PMCID: PMC7485575.
    Citations: 5     
  9. Otsuka K, Villiger M, van Zandvoort LJC, Neleman T, Karanasos A, Dijkstra J, van Soest G, Regar E, Nadkarni SK, Daemen J, Bouma BE. Polarimetric Signatures of Vascular Tissue Response to Drug-Eluting Stent Implantation in Patients. JACC Cardiovasc Imaging. 2020 12; 13(12):2695-2696. PMID: 32828773.
    Citations: 1     Fields:    Translation:Humans
  10. Tripathi MM, Tshikudi DM, Hajjarian Z, Hack DC, Van Cott EM, Nadkarni SK. Comprehensive Blood Coagulation Profiling in Patients Using iCoagLab: Comparison Against Thromboelastography. Thromb Haemost. 2020 Jul; 120(7):1116-1127. PMID: 32572866.
    Citations: 2     Fields:    Translation:Humans
  11. Hajjarian Z, Nadkarni SK. Tutorial on laser speckle rheology: technology, applications, and opportunities. J Biomed Opt. 2020 05; 25(5):1-19. PMID: 32358928; PMCID: PMC7195443.
    Citations: 4     Fields:    Translation:Humans
  12. Otsuka K, Villiger M, Nadkarni SK, Bouma BE. Intravascular Polarimetry for Tissue Characterization of Coronary Atherosclerosis. Circ Rep. 2019 Dec; 1(12):550-557. PMID: 32432174.
    Citations: 2     
  13. Otsuka K, Villiger M, Karanasos A, van Zandvoort LJC, Doradla P, Ren J, Lippok N, Daemen J, Diletti R, van Geuns RJ, Zijlstra F, van Soest G, Dijkstra J, Nadkarni SK, Regar E, Bouma BE. Intravascular Polarimetry in Patients With Coronary Artery Disease. JACC Cardiovasc Imaging. 2020 03; 13(3):790-801. PMID: 31422135.
    Citations: 6     Fields:    Translation:Humans
  14. Doradla P, Otsuka K, Nadkarni A, Villiger M, Karanasos A, Zandvoort LJCV, Dijkstra J, Zijlstra F, Soest GV, Daemen J, Regar E, Bouma BE, Nadkarni SK. Biomechanical Stress Profiling of Coronary Atherosclerosis: Identifying a Multifactorial Metric to Evaluate Plaque Rupture Risk. JACC Cardiovasc Imaging. 2020 03; 13(3):804-816. PMID: 31005542.
    Citations: 11     Fields:    Translation:Humans
  15. Nadkarni SK. Comprehensive Coagulation Profiling at the Point-of-Care Using a Novel Laser-Based Approach. Semin Thromb Hemost. 2019 Apr; 45(3):264-274. PMID: 30887486; PMCID: PMC7350951.
    Citations: 5     Fields:    Translation:Humans
  16. Villiger M, Braaf B, Lippok N, Otsuka K, Nadkarni SK, Bouma BE. Optic axis mapping with catheter-based polarization-sensitive optical coherence tomography. Optica. 2018 Oct 20; 5(10):1329-1337. PMID: 31214632; PMCID: PMC6581518.
    Citations: 17     
  17. Villiger M, Otsuka K, Karanasos A, Doradla P, Ren J, Lippok N, Shishkov M, Daemen J, Diletti R, van Geuns RJ, Zijlstra F, Dijkstra J, van Soest G, Regar E, Nadkarni SK, Bouma BE. Repeatability Assessment of Intravascular Polarimetry in Patients. IEEE Trans Med Imaging. 2018 07; 37(7):1618-1625. PMID: 29969412.
    Citations: 4     Fields:    Translation:Humans
  18. Villiger M, Otsuka K, Karanasos A, Doradla P, Ren J, Lippok N, Shishkov M, Daemen J, Diletti R, van Geuns RJ, Zijlstra F, van Soest G, Libby P, Regar E, Nadkarni SK, Bouma BE. Coronary Plaque Microstructure and Composition Modify Optical Polarization: A New Endogenous Contrast Mechanism for Optical Frequency Domain Imaging. JACC Cardiovasc Imaging. 2018 11; 11(11):1666-1676. PMID: 29248662.
    Citations: 25     Fields:    Translation:Humans
  19. Tripathi MM, Egawa S, Wirth AG, Tshikudi DM, Van Cott EM, Nadkarni SK. Clinical evaluation of whole blood prothrombin time (PT) and international normalized ratio (INR) using a Laser Speckle Rheology sensor. Sci Rep. 2017 08 23; 7(1):9169. PMID: 28835607.
    Citations: 11     Fields:    Translation:Humans
  20. Tshikudi DM, Tripathi MM, Hajjarian Z, Van Cott EM, Nadkarni SK. Optical sensing of anticoagulation status: Towards point-of-care coagulation testing. PLoS One. 2017; 12(8):e0182491. PMID: 28771571.
    Citations: 5     Fields:    Translation:HumansAnimals
  21. Hajjarian Z, Tshikudi DM, Nadkarni SK. Evaluating platelet aggregation dynamics from laser speckle fluctuations. Biomed Opt Express. 2017 Jul 01; 8(7):3502-3515. PMID: 28717586; PMCID: PMC5508847.
    Citations: 4     
  22. Wang J, Hosoda M, Tshikudi DM, Hajjarian Z, Nadkarni SK. Intraluminal laser speckle rheology using an omni-directional viewing catheter. Biomed Opt Express. 2017 Jan 01; 8(1):137-150. PMID: 28101407; PMCID: PMC5231287.
    Citations: 4     
  23. Hajjarian Z, Nia HT, Ahn S, Grodzinsky AJ, Jain RK, Nadkarni SK. Laser Speckle Rheology for evaluating the viscoelastic properties of hydrogel scaffolds. Sci Rep. 2016 12 01; 6:37949. PMID: 27905494.
    Citations: 13     Fields:    
  24. Suter MJ, Kashiwagi M, Gallagher KA, Nadkarni SK, Asanani N, Tanaka A, Conditt GB, Tellez A, Milewski K, Kaluza GL, Granada JF, Bouma BE, Tearney GJ. Optimizing flushing parameters in intracoronary optical coherence tomography: an in vivo swine study. Int J Cardiovasc Imaging. 2015 Aug; 31(6):1097-106. PMID: 25922149.
    Citations: 6     Fields:    Translation:Animals
  25. Hajjarian Z, Nadkarni SK. Estimation of particle size variations for laser speckle rheology of materials. Opt Lett. 2015 Mar 01; 40(5):764-7. PMID: 25723427.
    Citations: 6     Fields:    
  26. Wang J, Nadkarni SK. The influence of optical fiber bundle parameters on the transmission of laser speckle patterns. Opt Express. 2014 Apr 21; 22(8):8908-18. PMID: 24787780.
    Citations: 4     Fields:    
  27. Hajjarian Z, Tripathi MM, Nadkarni SK. Optical Thromboelastography to evaluate whole blood coagulation. J Biophotonics. 2015 May; 8(5):372-81. PMID: 24700701.
    Citations: 15     Fields:    Translation:HumansAnimals
  28. Hajjarian Z, Nadkarni SK. Correction of optical absorption and scattering variations in Laser Speckle Rheology measurements. Opt Express. 2014 Mar 24; 22(6):6349-61. PMID: 24663983.
    Citations: 13     Fields:    Translation:Cells
  29. Tripathi MM, Hajjarian Z, Van Cott EM, Nadkarni SK. Assessing blood coagulation status with laser speckle rheology. Biomed Opt Express. 2014 Mar 01; 5(3):817-31. PMID: 24688816.
    Citations: 26     
  30. Nadkarni SK. Optical measurement of arterial mechanical properties: from atherosclerotic plaque initiation to rupture. J Biomed Opt. 2013 Dec; 18(12):121507. PMID: 24296995.
    Citations: 6     Fields:    Translation:Humans
  31. Villiger M, Zhang EZ, Nadkarni SK, Oh WY, Vakoc BJ, Bouma BE. Spectral binning for mitigation of polarization mode dispersion artifacts in catheter-based optical frequency domain imaging. Opt Express. 2013 Jul 15; 21(14):16353-69. PMID: 23938487.
    Citations: 52     Fields:    Translation:Humans
  32. Hajjarian Z, Nadkarni SK. Evaluation and correction for optical scattering variations in laser speckle rheology of biological fluids. PLoS One. 2013; 8(5):e65014. PMID: 23705028.
    Citations: 16     Fields:    Translation:Animals
  33. Villiger M, Zhang EZ, Nadkarni S, Oh WY, Bouma BE, Vakoc BJ. Artifacts in polarization-sensitive optical coherence tomography caused by polarization mode dispersion. Opt Lett. 2013 Mar 15; 38(6):923-5. PMID: 23503261.
    Citations: 22     Fields:    
  34. Tearney GJ, Regar E, Akasaka T, Adriaenssens T, Barlis P, Bezerra HG, Bouma B, Bruining N, Cho JM, Chowdhary S, Costa MA, de Silva R, Dijkstra J, Di Mario C, Dudek D, Dudeck D, Falk E, Falk E, Feldman MD, Fitzgerald P, Garcia-Garcia HM, Garcia H, Gonzalo N, Granada JF, Guagliumi G, Holm NR, Honda Y, Ikeno F, Kawasaki M, Kochman J, Koltowski L, Kubo T, Kume T, Kyono H, Lam CC, Lamouche G, Lee DP, Leon MB, Maehara A, Manfrini O, Mintz GS, Mizuno K, Morel MA, Nadkarni S, Okura H, Otake H, Pietrasik A, Prati F, Räber L, Radu MD, Rieber J, Riga M, Rollins A, Rosenberg M, Sirbu V, Serruys PW, Shimada K, Shinke T, Shite J, Siegel E, Sonoda S, Sonada S, Suter M, Takarada S, Tanaka A, Terashima M, Thim T, Troels T, Uemura S, Ughi GJ, van Beusekom HM, van der Steen AF, van Es GA, van Es GA, van Soest G, Virmani R, Waxman S, Weissman NJ, Weisz G. Consensus standards for acquisition, measurement, and reporting of intravascular optical coherence tomography studies: a report from the International Working Group for Intravascular Optical Coherence Tomography Standardization and Validation. J Am Coll Cardiol. 2012 Mar 20; 59(12):1058-72. PMID: 22421299.
    Citations: 422     Fields:    Translation:Humans
  35. Hajjarian Z, Nadkarni SK. Evaluating the viscoelastic properties of tissue from laser speckle fluctuations. Sci Rep. 2012; 2:316. PMID: 22428085.
    Citations: 28     Fields:    
  36. Suter MJ, Nadkarni SK, Weisz G, Tanaka A, Jaffer FA, Bouma BE, Tearney GJ. Intravascular optical imaging technology for investigating the coronary artery. JACC Cardiovasc Imaging. 2011 Sep; 4(9):1022-39. PMID: 21920342.
    Citations: 41     Fields:    Translation:HumansAnimals
  37. Liu L, Gardecki JA, Nadkarni SK, Toussaint JD, Yagi Y, Bouma BE, Tearney GJ. Imaging the subcellular structure of human coronary atherosclerosis using micro-optical coherence tomography. Nat Med. 2011 Jul 10; 17(8):1010-4. PMID: 21743452.
    Citations: 145     Fields:    Translation:HumansAnimalsCells
  38. Hajjarian Z, Xi J, Jaffer FA, Tearney GJ, Nadkarni SK. Intravascular laser speckle imaging catheter for the mechanical evaluation of the arterial wall. J Biomed Opt. 2011 Feb; 16(2):026005. PMID: 21361689.
    Citations: 17     Fields:    Translation:Humans
  39. Hajjarian Z, Nadkarni SK. Measurement of bulk mechanical properties of tissue using laser speckle rheology. Annu Int Conf IEEE Eng Med Biol Soc. 2011; 2011:5746-8. PMID: 22255645.
    Citations: 1     Fields:    Translation:Humans
  40. Nadkarni SK, Bouma BE, Yelin D, Gulati A, Tearney GJ. Laser speckle imaging of atherosclerotic plaques through optical fiber bundles. J Biomed Opt. 2008 Sep-Oct; 13(5):054016. PMID: 19021396.
    Citations: 21     Fields:    Translation:Humans
  41. Nadkarni SK, Bouma BE, de Boer J, Tearney GJ. Evaluation of collagen in atherosclerotic plaques: the use of two coherent laser-based imaging methods. Lasers Med Sci. 2009 May; 24(3):439-45. PMID: 18386093.
    Citations: 23     Fields:    Translation:Humans
  42. Nadkarni SK, Pierce MC, Park BH, de Boer JF, Whittaker P, Bouma BE, Bressner JE, Halpern E, Houser SL, Tearney GJ. Measurement of collagen and smooth muscle cell content in atherosclerotic plaques using polarization-sensitive optical coherence tomography. J Am Coll Cardiol. 2007 Apr 03; 49(13):1474-81. PMID: 17397678; PMCID: PMC2785549.
    Citations: 74     Fields:    Translation:Humans
  43. Kawasaki M, Bouma BE, Bressner J, Houser SL, Nadkarni SK, MacNeill BD, Jang IK, Fujiwara H, Tearney GJ. Diagnostic accuracy of optical coherence tomography and integrated backscatter intravascular ultrasound images for tissue characterization of human coronary plaques. J Am Coll Cardiol. 2006 Jul 04; 48(1):81-8. PMID: 16814652.
    Citations: 48     Fields:    Translation:Humans
  44. Nadkarni SK, Bilenca A, Bouma BE, Tearney GJ. Measurement of fibrous cap thickness in atherosclerotic plaques by spatiotemporal analysis of laser speckle images. J Biomed Opt. 2006 Mar-Apr; 11(2):021006. PMID: 16674181.
    Citations: 23     Fields:    Translation:Humans
  45. Nadkarni SK, Bouma BE, Helg T, Chan R, Halpern E, Chau A, Minsky MS, Motz JT, Houser SL, Tearney GJ. Characterization of atherosclerotic plaques by laser speckle imaging. Circulation. 2005 Aug 09; 112(6):885-92. PMID: 16061738; PMCID: PMC2957879.
    Citations: 35     Fields:    Translation:Humans
  46. Nadkarni SK, Boughner D, Fenster A. Image-based cardiac gating for three-dimensional intravascular ultrasound imaging. Ultrasound Med Biol. 2005 Jan; 31(1):53-63. PMID: 15653231.
    Citations: 4     Fields:    Translation:Humans
  47. Chan R, Chau A, Karl W, Nadkarni S, Khalil A, Iftimia N, Shishkov M, Tearney G, Kaazempur-Mofrad M, Bouma B. OCT-based arterial elastography: robust estimation exploiting tissue biomechanics. Opt Express. 2004 Sep 20; 12(19):4558-72. PMID: 19484007.
    Citations: 27     Fields:    
  48. Chan, R; Chau, A; Karl, W; Nadkarni, S; Khalil, A; Iftimia, N; Shishkov, M; Tearney, G; Kaazempur-Mofrad, M; Bouma, B. Optics Express. OCT-based arterial elastography: robust estimation exploiting tissue biomechanics. 2004; 12(19):4558-4572.
  49. Nadkarni SK, Austin H, Mills G, Boughner D, Fenster A. A pulsating coronary vessel phantom for two- and three-dimensional intravascular ultrasound studies. Ultrasound Med Biol. 2003 Apr; 29(4):621-8. PMID: 12749933.
    Citations: 3     Fields:    
  50. Nadkarni SK, Boughner DR, Drangova M, Fenster A. In vitro simulation and quantification of temporal jitter artifacts in ECG-gated dynamic three-dimensional echocardiography. Ultrasound Med Biol. 2001 Feb; 27(2):211-22. PMID: 11316530.
    Citations: 1     Fields:    Translation:Humans
  51. Nadkarni SK, Boughner DR, Drangova M, Fenster A. Three-dimensional echocardiography: assessment of inter- and intra-operator variability and accuracy in the measurement of left ventricular cavity volume and myocardial mass. Phys Med Biol. 2000 May; 45(5):1255-73. PMID: 10843104.
    Citations: 1     Fields:    Translation:HumansAnimals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.