Harvard Catalyst Profiles

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Tanya Mayadas, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21AI154930 (MAYADAS, TANYA N) Jun 3, 2020 - May 31, 2022
    NIH
    Glycoengineering IgA1 in IgA nephropathy
    Role: Principal Investigator
  2. R01AI152522 (MAYADAS, TANYA N) Feb 10, 2020 - Jan 31, 2025
    NIH
    Neutrophil plasticity in autoimmune disease
    Role: Principal Investigator
  3. R21AI136527 (MAYADAS, TANYA N) Jan 22, 2018 - Dec 31, 2019
    NIH
    Generation and Characterization of Mice with Tissue Specific Expression of Lupus Risk ITGAM SNPs
    Role: Principal Investigator
  4. R01DK099507 (MAYADAS, TANYA N) Apr 1, 2014 - Mar 31, 2020
    NIH
    TNFR2 Regulation of Leukocyte Recruitment in Glomerulonephritis
    Role: Principal Investigator
  5. R01DK077111 (MAYADAS, TANYA N.) Jun 7, 2007 - Apr 30, 2012
    NIH
    Endothelia mechanisms of leukocyte accumulation in glomerulonephritis
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Mysore V, Cullere X, Settles ML, Ji X, Kattan MW, Desjardins M, Durbin-Johnson B, Gilboa T, Baden LR, Walt DR, Lichtman AH, Jehi L, Mayadas TN. Protective heterologous T cell immunity in COVID-19 induced by the trivalent MMR and Tdap vaccine antigens. Med (N Y). 2021 Sep 10; 2(9):1050-1071.e7. PMID: 34414383.
    Citations: 3     
  2. Mysore V, Cullere X, Mears J, Rosetti F, Okubo K, Liew PX, Zhang F, Madera-Salcedo I, Rosenbauer F, Stone RM, Aster JC, von Andrian UH, Lichtman AH, Raychaudhuri S, Mayadas TN. Fc?R engagement reprograms neutrophils into antigen cross-presenting cells that elicit acquired anti-tumor immunity. Nat Commun. 2021 08 09; 12(1):4791. PMID: 34373452.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  3. Okubo K, Brenner MD, Cullere X, Saggu G, Patchen ML, Bose N, Mihori S, Yuan Z, Lowell CA, Zhu C, Mayadas TN. Inhibitory affinity modulation of Fc?RIIA ligand binding by glycosphingolipids by inside-out signaling. Cell Rep. 2021 May 18; 35(7):109142. PMID: 34010642.
    Citations: 2     Fields:    
  4. Mysore V, Cullere X, Settles ML, Ji X, Kattan MW, Desjardins M, Durbin-Johnson B, Gilboa T, Baden LR, Walt DR, Lichtman A, Jehi L, Mayadas TN. Protective heterologous T cell immunity in COVID-19 induced by MMR and Tdap vaccine antigens. bioRxiv. 2021 May 04. PMID: 33972940.
    Citations:    
  5. Vorobyev A, Gupta Y, Sezin T, Koga H, Bartsch YC, Belheouane M, Künzel S, Sina C, Schilf P, Körber-Ahrens H, Beltsiou F, Lara Ernst A, Khil'chenko S, Al-Aasam H, Manz RA, Diehl S, Steinhaus M, Jascholt J, Kouki P, Boehncke WH, Mayadas TN, Zillikens D, Sadik CD, Nishi H, Ehlers M, Möller S, Bieber K, Baines JF, Ibrahim SM, Ludwig RJ. Gene-diet interactions associated with complex trait variation in an advanced intercross outbred mouse line. Nat Commun. 2019 09 10; 10(1):4097. PMID: 31506438.
    Citations: 6     Fields:    Translation:AnimalsCells
  6. Nishi H, Mayadas TN. Neutrophils in lupus nephritis. Curr Opin Rheumatol. 2019 03; 31(2):193-200. PMID: 30540580.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  7. Saggu G, Okubo K, Chen Y, Vattepu R, Tsuboi N, Rosetti F, Cullere X, Washburn N, Tahir S, Rosado AM, Holland SM, Anthony RM, Sen M, Zhu C, Mayadas TN. Cis interaction between sialylated Fc?RIIA and the aI-domain of Mac-1 limits antibody-mediated neutrophil recruitment. Nat Commun. 2018 11 29; 9(1):5058. PMID: 30498196.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  8. Chen B, Vousden KA, Naiman B, Turman S, Sun H, Wang S, Vinall LMK, Kemp BP, Kasturiangan S, Rees DG, Grant E, Hinrichs MJ, Eck S, DiGiandomenico A, Jack Borrok M, Ly N, Xiong X, Gonzalez C, Morehouse C, Wang Y, Zhou Y, Cann J, Zhao W, Koelkebeck H, Okubo K, Mayadas TN, Howe D, Griffiths J, Kolbeck R, Herbst R, Sims GP. Humanised effector-null Fc?RIIA antibody inhibits immune complex-mediated proinflammatory responses. Ann Rheum Dis. 2019 02; 78(2):228-237. PMID: 30459279.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  9. Okubo K, Kurosawa M, Kamiya M, Urano Y, Suzuki A, Yamamoto K, Hase K, Homma K, Sasaki J, Miyauchi H, Hoshino T, Hayashi M, Mayadas TN, Hirahashi J. Macrophage extracellular trap formation promoted by platelet activation is a key mediator of rhabdomyolysis-induced acute kidney injury. Nat Med. 2018 02; 24(2):232-238. PMID: 29309057.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  10. Nishi H, Furuhashi K, Cullere X, Saggu G, Miller MJ, Chen Y, Rosetti F, Hamilton SL, Yang L, Pittman SP, Liao J, Herter JM, Berry JC, DeAngelo DJ, Zhu C, Tsokos GC, Mayadas TN. Neutrophil Fc?RIIA promotes IgG-mediated glomerular neutrophil capture via Abl/Src kinases. J Clin Invest. 2017 Oct 02; 127(10):3810-3826. PMID: 28891817.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  11. Gordon RA, Herter JM, Rosetti F, Campbell AM, Nishi H, Kashgarian M, Bastacky SI, Marinov A, Nickerson KM, Mayadas TN, Shlomchik MJ. Lupus and proliferative nephritis are PAD4 independent in murine models. JCI Insight. 2017 May 18; 2(10). PMID: 28515361.
    Citations: 22     Fields:    
  12. Azcutia V, Bassil R, Herter JM, Engelbertsen D, Newton G, Autio A, Mayadas T, Lichtman AH, Khoury SJ, Parkos CA, Elyaman W, Luscinskas FW. Defects in CD4+ T cell LFA-1 integrin-dependent adhesion and proliferation protect Cd47-/- mice from EAE. J Leukoc Biol. 2017 02; 101(2):493-505. PMID: 27965383.
    Citations: 4     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  13. Yoshida N, Comte D, Mizui M, Otomo K, Rosetti F, Mayadas TN, Crispín JC, Bradley SJ, Koga T, Kono M, Karampetsou MP, Kyttaris VC, Tenbrock K, Tsokos GC. ICER is requisite for Th17 differentiation. Nat Commun. 2016 Sep 29; 7:12993. PMID: 27680869.
    Citations: 19     Fields:    
  14. Okubo K, Kamiya M, Urano Y, Nishi H, Herter JM, Mayadas T, Hirohama D, Suzuki K, Kawakami H, Tanaka M, Kurosawa M, Kagaya S, Hishikawa K, Nangaku M, Fujita T, Hayashi M, Hirahashi J. Lactoferrin Suppresses Neutrophil Extracellular Traps Release in Inflammation. EBioMedicine. 2016 Aug; 10:204-15. PMID: 27453322.
    Citations: 38     Fields:    Translation:HumansCells
  15. Li X, Cullere X, Nishi H, Saggu G, Durand E, Mansour MK, Tam JM, Song XY, Lin X, Vyas JM, Mayadas T. PKC-d activation in neutrophils promotes fungal clearance. J Leukoc Biol. 2016 09; 100(3):581-8. PMID: 26965632.
    Citations: 9     Fields:    Translation:AnimalsCells
  16. Buscher K, Wang H, Zhang X, Striewski P, Wirth B, Saggu G, Lütke-Enking S, Mayadas TN, Ley K, Sorokin L, Song J. Protection from septic peritonitis by rapid neutrophil recruitment through omental high endothelial venules. Nat Commun. 2016 Mar 04; 7:10828. PMID: 26940548.
    Citations: 24     Fields:    Translation:AnimalsCells
  17. Ernandez T, Mayadas TN. The Changing Landscape of Renal Inflammation. Trends Mol Med. 2016 Feb; 22(2):151-163. PMID: 26778189.
    Citations: 14     Fields:    Translation:HumansCells
  18. Rosetti F, Mayadas TN. The many faces of Mac-1 in autoimmune disease. Immunol Rev. 2016 Jan; 269(1):175-93. PMID: 26683153.
    Citations: 34     Fields:    Translation:HumansAnimals
  19. Herter JM, Grabie N, Cullere X, Azcutia V, Rosetti F, Bennett P, Herter-Sprie GS, Elyaman W, Luscinskas FW, Lichtman AH, Mayadas TN. AKAP9 regulates activation-induced retention of T lymphocytes at sites of inflammation. Nat Commun. 2015 Dec 18; 6:10182. PMID: 26680259.
    Citations: 11     Fields:    Translation:AnimalsCells
  20. Venkatesh D, Mruk D, Herter JM, Cullere X, Chojnacka K, Cheng CY, Mayadas TN. AKAP9, a Regulator of Microtubule Dynamics, Contributes to Blood-Testis Barrier Function. Am J Pathol. 2016 Feb; 186(2):270-84. PMID: 26687990.
    Citations: 7     Fields:    Translation:AnimalsCells
  21. Cullere X, Plovie E, Bennett PM, MacRae CA, Mayadas TN. The cerebral cavernous malformation proteins CCM2L and CCM2 prevent the activation of the MAP kinase MEKK3. Proc Natl Acad Sci U S A. 2015 Nov 17; 112(46):14284-9. PMID: 26540726.
    Citations: 27     Fields:    Translation:AnimalsCells
  22. Batal I, De Serres SA, Safa K, Bijol V, Ueno T, Onozato ML, Iafrate AJ, Herter JM, Lichtman AH, Mayadas TN, Guleria I, Rennke HG, Najafian N, Chandraker A. Dendritic Cells in Kidney Transplant Biopsy Samples Are Associated with T Cell Infiltration and Poor Allograft Survival. J Am Soc Nephrol. 2015 Dec; 26(12):3102-13. PMID: 25855773.
    Citations: 14     Fields:    Translation:HumansCells
  23. Rosetti F, Chen Y, Sen M, Thayer E, Azcutia V, Herter JM, Luscinskas FW, Cullere X, Zhu C, Mayadas TN. A Lupus-Associated Mac-1 Variant Has Defects in Integrin Allostery and Interaction with Ligands under Force. Cell Rep. 2015 Mar 17; 10(10):1655-1664. PMID: 25772353.
    Citations: 24     Fields:    
  24. Al-Lamki RS, Mayadas TN. TNF receptors: signaling pathways and contribution to renal dysfunction. Kidney Int. 2015 Feb; 87(2):281-96. PMID: 25140911.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  25. Ganesan S, Rathinam VAK, Bossaller L, Army K, Kaiser WJ, Mocarski ES, Dillon CP, Green DR, Mayadas TN, Levitz SM, Hise AG, Silverman N, Fitzgerald KA. Caspase-8 modulates dectin-1 and complement receptor 3-driven IL-1ß production in response to ß-glucans and the fungal pathogen, Candida albicans. J Immunol. 2014 Sep 01; 193(5):2519-2530. PMID: 25063877.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  26. Herter JM, Mayadas TN. Midkine, a middle manager of ß2 integrins. Blood. 2014 Mar 20; 123(12):1777-9. PMID: 24652961.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  27. Mayadas TN, Cullere X, Lowell CA. The multifaceted functions of neutrophils. Annu Rev Pathol. 2014; 9:181-218. PMID: 24050624.
    Citations: 330     Fields:    Translation:HumansAnimalsCells
  28. Kannan L, Kis-Toth K, Yoshiya K, Thai TH, Sehrawat S, Mayadas TN, Dalle Lucca JJ, Tsokos GC. R-spondin3 prevents mesenteric ischemia/reperfusion-induced tissue damage by tightening endothelium and preventing vascular leakage. Proc Natl Acad Sci U S A. 2013 Aug 27; 110(35):14348-53. PMID: 23942120.
    Citations: 11     Fields:    Translation:AnimalsCells
  29. Adams WJ, Zhang Y, Cloutier J, Kuchimanchi P, Newton G, Sehrawat S, Aird WC, Mayadas TN, Luscinskas FW, García-Cardeña G. Functional vascular endothelium derived from human induced pluripotent stem cells. Stem Cell Reports. 2013; 1(2):105-13. PMID: 24052946.
    Citations: 70     Fields:    Translation:HumansCells
  30. Venkatesh D, Ernandez T, Rosetti F, Batal I, Cullere X, Luscinskas FW, Zhang Y, Stavrakis G, García-Cardeña G, Horwitz BH, Mayadas TN. Endothelial TNF receptor 2 induces IRF1 transcription factor-dependent interferon-ß autocrine signaling to promote monocyte recruitment. Immunity. 2013 May 23; 38(5):1025-37. PMID: 23623383.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  31. Pisitkun P, Ha HL, Wang H, Claudio E, Tivy CC, Zhou H, Mayadas TN, Illei GG, Siebenlist U. Interleukin-17 cytokines are critical in development of fatal lupus glomerulonephritis. Immunity. 2012 Dec 14; 37(6):1104-15. PMID: 23123062.
    Citations: 66     Fields:    Translation:AnimalsCells
  32. Chen K, Nishi H, Travers R, Tsuboi N, Martinod K, Wagner DD, Stan R, Croce K, Mayadas TN. Endocytosis of soluble immune complexes leads to their clearance by Fc?RIIIB but induces neutrophil extracellular traps via Fc?RIIA in vivo. Blood. 2012 Nov 22; 120(22):4421-31. PMID: 22955924.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  33. Rosetti F, Tsuboi N, Chen K, Nishi H, Ernandez T, Sethi S, Croce K, Stavrakis G, Alcocer-Varela J, Gómez-Martin D, van Rooijen N, Kyttaris VC, Lichtman AH, Tsokos GC, Mayadas TN. Human lupus serum induces neutrophil-mediated organ damage in mice that is enabled by Mac-1 deficiency. J Immunol. 2012 Oct 01; 189(7):3714-23. PMID: 22933624.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  34. Azcutia V, Stefanidakis M, Tsuboi N, Mayadas T, Croce KJ, Fukuda D, Aikawa M, Newton G, Luscinskas FW. Endothelial CD47 promotes vascular endothelial-cadherin tyrosine phosphorylation and participates in T cell recruitment at sites of inflammation in vivo. J Immunol. 2012 Sep 01; 189(5):2553-62. PMID: 22815286.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  35. Fu H, Liu B, Frost JL, Hong S, Jin M, Ostaszewski B, Shankar GM, Costantino IM, Carroll MC, Mayadas TN, Lemere CA. Complement component C3 and complement receptor type 3 contribute to the phagocytosis and clearance of fibrillar Aß by microglia. Glia. 2012 May; 60(6):993-1003. PMID: 22438044.
    Citations: 72     Fields:    Translation:HumansAnimalsCells
  36. Crispín JC, Apostolidis SA, Rosetti F, Keszei M, Wang N, Terhorst C, Mayadas TN, Tsokos GC. Cutting edge: protein phosphatase 2A confers susceptibility to autoimmune disease through an IL-17-dependent mechanism. J Immunol. 2012 Apr 15; 188(8):3567-71. PMID: 22422882.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  37. Niewczas MA, Gohda T, Skupien J, Smiles AM, Walker WH, Rosetti F, Cullere X, Eckfeldt JH, Doria A, Mayadas TN, Warram JH, Krolewski AS. Circulating TNF receptors 1 and 2 predict ESRD in type 2 diabetes. J Am Soc Nephrol. 2012 Mar; 23(3):507-15. PMID: 22266663.
    Citations: 182     Fields:    Translation:HumansCells
  38. Gohda T, Niewczas MA, Ficociello LH, Walker WH, Skupien J, Rosetti F, Cullere X, Johnson AC, Crabtree G, Smiles AM, Mayadas TN, Warram JH, Krolewski AS. Circulating TNF receptors 1 and 2 predict stage 3 CKD in type 1 diabetes. J Am Soc Nephrol. 2012 Mar; 23(3):516-24. PMID: 22266664.
    Citations: 147     Fields:    Translation:HumansCells
  39. Lowell CA, Mayadas TN. Overview: studying integrins in vivo. Methods Mol Biol. 2012; 757:369-97. PMID: 21909923.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  40. Li X, Utomo A, Cullere X, Choi MM, Milner DA, Venkatesh D, Yun SH, Mayadas TN. The ß-glucan receptor Dectin-1 activates the integrin Mac-1 in neutrophils via Vav protein signaling to promote Candida albicans clearance. Cell Host Microbe. 2011 Dec 15; 10(6):603-15. PMID: 22177564.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  41. Tsuboi N, Ernandez T, Li X, Nishi H, Cullere X, Mekala D, Hazen M, Köhl J, Lee DM, Mayadas TN. Regulation of human neutrophil Fc? receptor IIa by C5a receptor promotes inflammatory arthritis in mice. Arthritis Rheum. 2011 Feb; 63(2):467-78. PMID: 21280001.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  42. Sehrawat S, Ernandez T, Cullere X, Takahashi M, Ono Y, Komarova Y, Mayadas TN. AKAP9 regulation of microtubule dynamics promotes Epac1-induced endothelial barrier properties. Blood. 2011 Jan 13; 117(2):708-18. PMID: 20952690.
    Citations: 31     Fields:    Translation:HumansCells
  43. Mayadas TN, Rosetti F, Ernandez T, Sethi S. Neutrophils: game changers in glomerulonephritis? Trends Mol Med. 2010 Aug; 16(8):368-78. PMID: 20667782.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  44. Mayadas TN, Tsokos GC, Tsuboi N. Mechanisms of immune complex-mediated neutrophil recruitment and tissue injury. Circulation. 2009 Nov 17; 120(20):2012-24. PMID: 19917895.
    Citations: 75     Fields:    Translation:HumansAnimalsCells
  45. Hirahashi J, Hishikawa K, Kaname S, Tsuboi N, Wang Y, Simon DI, Stavrakis G, Shimosawa T, Xiao L, Nagahama Y, Suzuki K, Fujita T, Mayadas TN. Mac-1 (CD11b/CD18) links inflammation and thrombosis after glomerular injury. Circulation. 2009 Sep 29; 120(13):1255-65. PMID: 19752320.
    Citations: 38     Fields:    Translation:AnimalsCells
  46. Ernandez T, Mayadas TN. Immunoregulatory role of TNFalpha in inflammatory kidney diseases. Kidney Int. 2009 Aug; 76(3):262-76. PMID: 19436333.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  47. Lichtnekert J, Vielhauer V, Zecher D, Kulkarni OP, Clauss S, Segerer S, Hornung V, Mayadas TN, Beutler B, Akira S, Anders HJ. Trif is not required for immune complex glomerulonephritis: dying cells activate mesangial cells via Tlr2/Myd88 rather than Tlr3/Trif. Am J Physiol Renal Physiol. 2009 Apr; 296(4):F867-74. PMID: 19158348.
    Citations: 18     Fields:    Translation:AnimalsCells
  48. Alcaide P, Newton G, Auerbach S, Sehrawat S, Mayadas TN, Golan DE, Yacono P, Vincent P, Kowalczyk A, Luscinskas FW. p120-Catenin regulates leukocyte transmigration through an effect on VE-cadherin phosphorylation. Blood. 2008 Oct 01; 112(7):2770-9. PMID: 18641366.
    Citations: 57     Fields:    Translation:HumansCells
  49. Tsuboi N, Asano K, Lauterbach M, Mayadas TN. Human neutrophil Fcgamma receptors initiate and play specialized nonredundant roles in antibody-mediated inflammatory diseases. Immunity. 2008 Jun; 28(6):833-46. PMID: 18538590.
    Citations: 68     Fields:    Translation:HumansAnimalsCells
  50. Utomo A, Hirahashi J, Mekala D, Asano K, Glogauer M, Cullere X, Mayadas TN. Requirement for Vav proteins in post-recruitment neutrophil cytotoxicity in IgG but not complement C3-dependent injury. J Immunol. 2008 May 01; 180(9):6279-87. PMID: 18424751.
    Citations: 10     Fields:    Translation:AnimalsCells
  51. Lauterbach M, O'Donnell P, Asano K, Mayadas TN. Role of TNF priming and adhesion molecules in neutrophil recruitment to intravascular immune complexes. J Leukoc Biol. 2008 Jun; 83(6):1423-30. PMID: 18372339.
    Citations: 22     Fields:    Translation:AnimalsCells
  52. Cullere X, Lauterbach M, Tsuboi N, Mayadas TN. Neutrophil-selective CD18 silencing using RNA interference in vivo. Blood. 2008 Apr 01; 111(7):3591-8. PMID: 18216298.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  53. Sehrawat S, Cullere X, Patel S, Italiano J, Mayadas TN. Role of Epac1, an exchange factor for Rap GTPases, in endothelial microtubule dynamics and barrier function. Mol Biol Cell. 2008 Mar; 19(3):1261-70. PMID: 18172027.
    Citations: 58     Fields:    Translation:HumansCells
  54. Menke J, Lucas JA, Zeller GC, Keir ME, Huang XR, Tsuboi N, Mayadas TN, Lan HY, Sharpe AH, Kelley VR. Programmed death 1 ligand (PD-L) 1 and PD-L2 limit autoimmune kidney disease: distinct roles. J Immunol. 2007 Dec 01; 179(11):7466-77. PMID: 18025191.
    Citations: 35     Fields:    Translation:AnimalsCells
  55. Dole VS, Bergmeier W, Patten IS, Hirahashi J, Mayadas TN, Wagner DD. PSGL-1 regulates platelet P-selectin-mediated endothelial activation and shedding of P-selectin from activated platelets. Thromb Haemost. 2007 Oct; 98(4):806-12. PMID: 17938805.
    Citations: 19     Fields:    Translation:AnimalsCells
  56. Ghandour H, Cullere X, Alvarez A, Luscinskas FW, Mayadas TN. Essential role for Rap1 GTPase and its guanine exchange factor CalDAG-GEFI in LFA-1 but not VLA-4 integrin mediated human T-cell adhesion. Blood. 2007 Nov 15; 110(10):3682-90. PMID: 17702895.
    Citations: 56     Fields:    Translation:HumansCells
  57. Sisco M, Chao JD, Kim I, Mogford JE, Mayadas TN, Mustoe TA. Delayed wound healing in Mac-1-deficient mice is associated with normal monocyte recruitment. Wound Repair Regen. 2007 Jul-Aug; 15(4):566-71. PMID: 17650101.
    Citations: 8     Fields:    Translation:AnimalsCells
  58. Vielhauer V, Mayadas TN. Functions of TNF and its receptors in renal disease: distinct roles in inflammatory tissue injury and immune regulation. Semin Nephrol. 2007 May; 27(3):286-308. PMID: 17533007.
    Citations: 43     Fields:    Translation:HumansAnimals
  59. Sircar M, Bradfield PF, Aurrand-Lions M, Fish RJ, Alcaide P, Yang L, Newton G, Lamont D, Sehrawat S, Mayadas T, Liang TW, Parkos CA, Imhof BA, Luscinskas FW. Neutrophil transmigration under shear flow conditions in vitro is junctional adhesion molecule-C independent. J Immunol. 2007 May 01; 178(9):5879-87. PMID: 17442972.
    Citations: 17     Fields:    Translation:AnimalsCells
  60. Utomo A, Cullere X, Glogauer M, Swat W, Mayadas TN. Vav proteins in neutrophils are required for FcgammaR-mediated signaling to Rac GTPases and nicotinamide adenine dinucleotide phosphate oxidase component p40(phox). J Immunol. 2006 Nov 01; 177(9):6388-97. PMID: 17056570.
    Citations: 34     Fields:    Translation:AnimalsCells
  61. Hirahashi J, Mekala D, Van Ziffle J, Xiao L, Saffaripour S, Wagner DD, Shapiro SD, Lowell C, Mayadas TN. Mac-1 signaling via Src-family and Syk kinases results in elastase-dependent thrombohemorrhagic vasculopathy. Immunity. 2006 Aug; 25(2):271-83. PMID: 16872848.
    Citations: 59     Fields:    Translation:AnimalsCells
  62. Liu Z, Zhao M, Li N, Diaz LA, Mayadas TN. Differential roles for beta2 integrins in experimental autoimmune bullous pemphigoid. Blood. 2006 Feb 01; 107(3):1063-9. PMID: 16234355.
    Citations: 13     Fields:    Translation:AnimalsCells
  63. Hochegger K, Siebenhaar F, Vielhauer V, Heininger D, Mayadas TN, Mayer G, Maurer M, Rosenkranz AR. Role of mast cells in experimental anti-glomerular basement membrane glomerulonephritis. Eur J Immunol. 2005 Oct; 35(10):3074-82. PMID: 16180252.
    Citations: 30     Fields:    Translation:AnimalsCells
  64. Mayadas TN, Cullere X. Neutrophil beta2 integrins: moderators of life or death decisions. Trends Immunol. 2005 Jul; 26(7):388-95. PMID: 15922663.
    Citations: 83     Fields:    Translation:HumansAnimalsCells
  65. Vielhauer V, Stavrakis G, Mayadas TN. Renal cell-expressed TNF receptor 2, not receptor 1, is essential for the development of glomerulonephritis. J Clin Invest. 2005 May; 115(5):1199-209. PMID: 15841213.
    Citations: 44     Fields:    Translation:AnimalsCells
  66. Stokol T, O'Donnell P, Xiao L, Knight S, Stavrakis G, Botto M, von Andrian UH, Mayadas TN. C1q governs deposition of circulating immune complexes and leukocyte Fcgamma receptors mediate subsequent neutrophil recruitment. J Exp Med. 2004 Oct 04; 200(7):835-46. PMID: 15466618.
    Citations: 27     Fields:    Translation:AnimalsCells
  67. Cullere X, Shaw SK, Andersson L, Hirahashi J, Luscinskas FW, Mayadas TN. Regulation of vascular endothelial barrier function by Epac, a cAMP-activated exchange factor for Rap GTPase. Blood. 2005 Mar 01; 105(5):1950-5. PMID: 15374886.
    Citations: 170     Fields:    Translation:HumansCells
  68. Embury SH, Matsui NM, Ramanujam S, Mayadas TN, Noguchi CT, Diwan BA, Mohandas N, Cheung AT. The contribution of endothelial cell P-selectin to the microvascular flow of mouse sickle erythrocytes in vivo. Blood. 2004 Nov 15; 104(10):3378-85. PMID: 15271798.
    Citations: 49     Fields:    Translation:AnimalsCells
  69. Gakidis MA, Cullere X, Olson T, Wilsbacher JL, Zhang B, Moores SL, Ley K, Swat W, Mayadas T, Brugge JS. Vav GEFs are required for beta2 integrin-dependent functions of neutrophils. J Cell Biol. 2004 Jul 19; 166(2):273-82. PMID: 15249579.
    Citations: 77     Fields:    Translation:AnimalsCells
  70. Combes V, Rosenkranz AR, Redard M, Pizzolato G, Lepidi H, Vestweber D, Mayadas TN, Grau GE. Pathogenic role of P-selectin in experimental cerebral malaria: importance of the endothelial compartment. Am J Pathol. 2004 Mar; 164(3):781-6. PMID: 14982832.
    Citations: 16     Fields:    Translation:AnimalsCells
  71. Hochegger K, Knight S, Hugo C, Mayer G, Lawler J, Mayadas TN, Rosenkranz AR. Role of thrombospondin-1 in the autologous phase of an accelerated model of anti-glomerular basement membrane glomerulonephritis. Nephron Exp Nephrol. 2004; 96(2):e31-8. PMID: 14988590.
    Citations: 3     Fields:    Translation:Animals
  72. Zhang B, Hirahashi J, Cullere X, Mayadas TN. Elucidation of molecular events leading to neutrophil apoptosis following phagocytosis: cross-talk between caspase 8, reactive oxygen species, and MAPK/ERK activation. J Biol Chem. 2003 Aug 01; 278(31):28443-54. PMID: 12736263.
    Citations: 71     Fields:    Translation:HumansAnimalsCells
  73. Hoffmeister KM, Felbinger TW, Falet H, Denis CV, Bergmeier W, Mayadas TN, von Andrian UH, Wagner DD, Stossel TP, Hartwig JH. The clearance mechanism of chilled blood platelets. Cell. 2003 Jan 10; 112(1):87-97. PMID: 12526796.
    Citations: 102     Fields:    Translation:HumansAnimalsCells
  74. Henneke P, Takeuchi O, Malley R, Lien E, Ingalls RR, Freeman MW, Mayadas T, Nizet V, Akira S, Kasper DL, Golenbock DT. Cellular activation, phagocytosis, and bactericidal activity against group B streptococcus involve parallel myeloid differentiation factor 88-dependent and independent signaling pathways. J Immunol. 2002 Oct 01; 169(7):3970-7. PMID: 12244198.
    Citations: 63     Fields:    Translation:HumansAnimalsCells
  75. Sethi S, Ziouzenkova O, Ni H, Wagner DD, Plutzky J, Mayadas TN. Oxidized omega-3 fatty acids in fish oil inhibit leukocyte-endothelial interactions through activation of PPAR alpha. Blood. 2002 Aug 15; 100(4):1340-6. PMID: 12149216.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  76. Coxon A, Cullere X, Knight S, Sethi S, Wakelin MW, Stavrakis G, Luscinskas FW, Mayadas TN. Fc gamma RIII mediates neutrophil recruitment to immune complexes. a mechanism for neutrophil accumulation in immune-mediated inflammation. Immunity. 2001 Jun; 14(6):693-704. PMID: 11420040.
    Citations: 79     Fields:    Translation:HumansAnimalsCells
  77. Niederman R, Westernoff T, Lee C, Mark LL, Kawashima N, Ullman-Culler M, Dewhirst FE, Paster BJ, Wagner DD, Mayadas T, Hynes RO, Stashenko P. Infection-mediated early-onset periodontal disease in P/E-selectin-deficient mice. J Clin Periodontol. 2001 Jun; 28(6):569-75. PMID: 11350525.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  78. van Spriel AB, Leusen JH, van Egmond M, Dijkman HB, Assmann KJ, Mayadas TN, van de Winkel JG. Mac-1 (CD11b/CD18) is essential for Fc receptor-mediated neutrophil cytotoxicity and immunologic synapse formation. Blood. 2001 Apr 15; 97(8):2478-86. PMID: 11290613.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  79. Ren Y, Stuart L, Lindberg FP, Rosenkranz AR, Chen Y, Mayadas TN, Savill J. Nonphlogistic clearance of late apoptotic neutrophils by macrophages: efficient phagocytosis independent of beta 2 integrins. J Immunol. 2001 Apr 01; 166(7):4743-50. PMID: 11254736.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  80. Perera PY, Mayadas TN, Takeuchi O, Akira S, Zaks-Zilberman M, Goyert SM, Vogel SN. CD11b/CD18 acts in concert with CD14 and Toll-like receptor (TLR) 4 to elicit full lipopolysaccharide and taxol-inducible gene expression. J Immunol. 2001 Jan 01; 166(1):574-81. PMID: 11123339.
    Citations: 94     Fields:    Translation:AnimalsCells
  81. Barkalow FJ, Barkalow KL, Mayadas TN. Dimerization of P-selectin in platelets and endothelial cells. Blood. 2000 Nov 01; 96(9):3070-7. PMID: 11049986.
    Citations: 18     Fields:    Translation:HumansCells
  82. Rosenkranz AR, Knight S, Sethi S, Alexander SI, Cotran RS, Mayadas TN. Regulatory interactions of alphabeta and gammadelta T cells in glomerulonephritis. Kidney Int. 2000 Sep; 58(3):1055-66. PMID: 10972670.
    Citations: 17     Fields:    Translation:AnimalsCells
  83. Yan J, Vetvicka V, Xia Y, Hanikýrová M, Mayadas TN, Ross GD. Critical role of Kupffer cell CR3 (CD11b/CD18) in the clearance of IgM-opsonized erythrocytes or soluble beta-glucan. Immunopharmacology. 2000 Jan; 46(1):39-54. PMID: 10665778.
    Citations: 22     Fields:    Translation:AnimalsCells
  84. Coxon A, Tang T, Mayadas TN. Cytokine-activated endothelial cells delay neutrophil apoptosis in vitro and in vivo. A role for granulocyte/macrophage colony-stimulating factor. J Exp Med. 1999 Oct 04; 190(7):923-34. PMID: 10510082.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  85. Yan J, Vetvicka V, Xia Y, Coxon A, Carroll MC, Mayadas TN, Ross GD. Beta-glucan, a "specific" biologic response modifier that uses antibodies to target tumors for cytotoxic recognition by leukocyte complement receptor type 3 (CD11b/CD18). J Immunol. 1999 Sep 15; 163(6):3045-52. PMID: 10477568.
    Citations: 28     Fields:    Translation:AnimalsCells
  86. Bhat N, Perera PY, Carboni JM, Blanco J, Golenbock DT, Mayadas TN, Vogel SN. Use of a photoactivatable taxol analogue to identify unique cellular targets in murine macrophages: identification of murine CD18 as a major taxol-binding protein and a role for Mac-1 in taxol-induced gene expression. J Immunol. 1999 Jun 15; 162(12):7335-42. PMID: 10358184.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  87. van Egmond M, van Vuuren AJ, Morton HC, van Spriel AB, Shen L, Hofhuis FM, Saito T, Mayadas TN, Verbeek JS, van de Winkel JG. Human immunoglobulin A receptor (FcalphaRI, CD89) function in transgenic mice requires both FcR gamma chain and CR3 (CD11b/CD18). Blood. 1999 Jun 15; 93(12):4387-94. PMID: 10361137.
    Citations: 31     Fields:    Translation:HumansAnimals
  88. Mayadas TN, Rosenkranz A, Cotran RS. Glomerular inflammation: use of genetically deficient mice to elucidate the roles of leukocyte adhesion molecules and Fc-gamma receptors in vivo. Curr Opin Nephrol Hypertens. 1999 May; 8(3):293-8. PMID: 10456259.
    Citations: 5     Fields:    Translation:AnimalsCells
  89. Rosenkranz AR, Mendrick DL, Cotran RS, Mayadas TN. P-selectin deficiency exacerbates experimental glomerulonephritis: a protective role for endothelial P-selectin in inflammation. J Clin Invest. 1999 Mar; 103(5):649-59. PMID: 10074481.
    Citations: 40     Fields:    Translation:Animals
  90. Rosenkranz AR, Mayadas TN. Leukocyte-endothelial cell interactions - lessons from knockout mice. Exp Nephrol. 1999 Mar-Apr; 7(2):125-36. PMID: 10213866.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  91. Xia Y, Vetvicka V, Yan J, Hanikýrová M, Mayadas T, Ross GD. The beta-glucan-binding lectin site of mouse CR3 (CD11b/CD18) and its function in generating a primed state of the receptor that mediates cytotoxic activation in response to iC3b-opsonized target cells. J Immunol. 1999 Feb 15; 162(4):2281-90. PMID: 9973505.
    Citations: 72     Fields:    Translation:AnimalsCells
  92. Soriano SG, Coxon A, Wang YF, Frosch MP, Lipton SA, Hickey PR, Mayadas TN. Mice deficient in Mac-1 (CD11b/CD18) are less susceptible to cerebral ischemia/reperfusion injury. Stroke. 1999 Jan; 30(1):134-9. PMID: 9880401.
    Citations: 70     Fields:    Translation:AnimalsCells
  93. Rosenkranz AR, Coxon A, Maurer M, Gurish MF, Austen KF, Friend DS, Galli SJ, Mayadas TN. Impaired mast cell development and innate immunity in Mac-1 (CD11b/CD18, CR3)-deficient mice. J Immunol. 1998 Dec 15; 161(12):6463-7. PMID: 9862668.
    Citations: 35     Fields:    Translation:AnimalsCells
  94. Hartwell DW, Mayadas TN, Berger G, Frenette PS, Rayburn H, Hynes RO, Wagner DD. Role of P-selectin cytoplasmic domain in granular targeting in vivo and in early inflammatory responses. J Cell Biol. 1998 Nov 16; 143(4):1129-41. PMID: 9817767.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  95. Tang T, Rosenkranz A, Assmann KJ, Goodman MJ, Gutierrez-Ramos JC, Carroll MC, Cotran RS, Mayadas TN. A role for Mac-1 (CDIIb/CD18) in immune complex-stimulated neutrophil function in vivo: Mac-1 deficiency abrogates sustained Fcgamma receptor-dependent neutrophil adhesion and complement-dependent proteinuria in acute glomerulonephritis. J Exp Med. 1997 Dec 01; 186(11):1853-63. PMID: 9382884.
    Citations: 68     Fields:    Translation:AnimalsCells
  96. Dong ZM, Gutierrez-Ramos JC, Coxon A, Mayadas TN, Wagner DD. A new class of obesity genes encodes leukocyte adhesion receptors. Proc Natl Acad Sci U S A. 1997 Jul 08; 94(14):7526-30. PMID: 9207125.
    Citations: 25     Fields:    Translation:Animals
  97. Subramaniam M, Saffaripour S, Van De Water L, Frenette PS, Mayadas TN, Hynes RO, Wagner DD. Role of endothelial selectins in wound repair. Am J Pathol. 1997 May; 150(5):1701-9. PMID: 9137094.
    Citations: 32     Fields:    Translation:AnimalsCells
  98. Johnson RC, Chapman SM, Dong ZM, Ordovas JM, Mayadas TN, Herz J, Hynes RO, Schaefer EJ, Wagner DD. Absence of P-selectin delays fatty streak formation in mice. J Clin Invest. 1997 Mar 01; 99(5):1037-43. PMID: 9062362.
    Citations: 52     Fields:    Translation:AnimalsCells
  99. Barkalow FJ, Goodman MJ, Gerritsen ME, Mayadas TN. Brain endothelium lack one of two pathways of P-selectin-mediated neutrophil adhesion. Blood. 1996 Dec 15; 88(12):4585-93. PMID: 8977250.
    Citations: 30     Fields:    Translation:AnimalsCells
  100. Coxon A, Rieu P, Barkalow FJ, Askari S, Sharpe AH, von Andrian UH, Arnaout MA, Mayadas TN. A novel role for the beta 2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation. Immunity. 1996 Dec; 5(6):653-66. PMID: 8986723.
    Citations: 217     Fields:    Translation:HumansAnimalsCells
  101. Tang T, Frenette PS, Hynes RO, Wagner DD, Mayadas TN. Cytokine-induced meningitis is dramatically attenuated in mice deficient in endothelial selectins. J Clin Invest. 1996 Jun 01; 97(11):2485-90. PMID: 8647940.
    Citations: 24     Fields:    Translation:AnimalsCells
  102. Mayadas TN, Mendrick DL, Brady HR, Tang T, Papayianni A, Assmann KJ, Wagner DD, Hynes RO, Cotran RS. Acute passive anti-glomerular basement membrane nephritis in P-selectin-deficient mice. Kidney Int. 1996 May; 49(5):1342-9. PMID: 8731099.
    Citations: 14     Fields:    Translation:AnimalsCells
  103. Frenette PS, Mayadas TN, Rayburn H, Hynes RO, Wagner DD. Double knockout highlights value of endothelial selectins. Immunol Today. 1996 May; 17(5):205. PMID: 8991376.
    Citations: 3     Fields:    Translation:Animals
  104. Barkalow FJ, Goodman MJ, Mayadas TN. Cultured murine cerebral microvascular endothelial cells contain von Willebrand factor-positive Weibel-Palade bodies and support rapid cytokine-induced neutrophil adhesion. Microcirculation. 1996 Mar; 3(1):19-28. PMID: 8846268.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  105. Frenette PS, Mayadas TN, Rayburn H, Hynes RO, Wagner DD. Susceptibility to infection and altered hematopoiesis in mice deficient in both P- and E-selectins. Cell. 1996 Feb 23; 84(4):563-74. PMID: 8598043.
    Citations: 146     Fields:    Translation:AnimalsCells
  106. Pinsky DJ, Naka Y, Liao H, Oz MC, Wagner DD, Mayadas TN, Johnson RC, Hynes RO, Heath M, Lawson CA, Stern DM. Hypoxia-induced exocytosis of endothelial cell Weibel-Palade bodies. A mechanism for rapid neutrophil recruitment after cardiac preservation. J Clin Invest. 1996 Jan 15; 97(2):493-500. PMID: 8567972.
    Citations: 76     Fields:    Translation:HumansAnimalsCells
  107. Yamada S, Mayadas TN, Yuan F, Wagner DD, Hynes RO, Melder RJ, Jain RK. Rolling in P-selectin-deficient mice is reduced but not eliminated in the dorsal skin. Blood. 1995 Nov 01; 86(9):3487-92. PMID: 7579454.
    Citations: 6     Fields:    Translation:AnimalsCells
  108. Johnson RC, Mayadas TN, Frenette PS, Mebius RE, Subramaniam M, Lacasce A, Hynes RO, Wagner DD. Blood cell dynamics in P-selectin-deficient mice. Blood. 1995 Aug 01; 86(3):1106-14. PMID: 7542495.
    Citations: 26     Fields:    Translation:AnimalsCells
  109. Mayadas TN. Gene knockout on P-selectin: Its biology and function. Trends Cardiovasc Med. 1995 Jul-Aug; 5(4):149-57. PMID: 21232252.
    Citations: 3     Fields:    
  110. Subramaniam M, Saffaripour S, Watson SR, Mayadas TN, Hynes RO, Wagner DD. Reduced recruitment of inflammatory cells in a contact hypersensitivity response in P-selectin-deficient mice. J Exp Med. 1995 Jun 01; 181(6):2277-82. PMID: 7539046.
    Citations: 37     Fields:    Translation:AnimalsCells
  111. Mayadas TN, Johnson RC, Rayburn H, Hynes RO, Wagner DD. Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice. Cell. 1993 Aug 13; 74(3):541-54. PMID: 7688665.
    Citations: 250     Fields:    Translation:AnimalsCells
  112. Mayadas TN, Wagner DD. Vicinal cysteines in the prosequence play a role in von Willebrand factor multimer assembly. Proc Natl Acad Sci U S A. 1992 Apr 15; 89(8):3531-5. PMID: 1565649.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  113. Wagner DD, Saffaripour S, Bonfanti R, Sadler JE, Cramer EM, Chapman B, Mayadas TN. Induction of specific storage organelles by von Willebrand factor propolypeptide. Cell. 1991 Jan 25; 64(2):403-13. PMID: 1988154.
    Citations: 79     Fields:    Translation:HumansAnimalsCells
  114. Mayadas TN, Wagner DD. von Willebrand factor biosynthesis and processing. Ann N Y Acad Sci. 1991; 614:153-66. PMID: 2024882.
    Citations: 11     Fields:    Translation:HumansCells
  115. Mayadas TN, Wagner DD. In vitro multimerization of von Willebrand factor is triggered by low pH. Importance of the propolypeptide and free sulfhydryls. J Biol Chem. 1989 Aug 15; 264(23):13497-503. PMID: 2788160.
    Citations: 27     Fields:    Translation:HumansCells
  116. Mayadas T, Wagner DD, Simpson PJ. von Willebrand factor biosynthesis and partitioning between constitutive and regulated pathways of secretion after thrombin stimulation. Blood. 1989 Feb 15; 73(3):706-11. PMID: 2783866.
    Citations: 8     Fields:    Translation:HumansCells
  117. Wagner DD, Mayadas T, Marder VJ. Initial glycosylation and acidic pH in the Golgi apparatus are required for multimerization of von Willebrand factor. J Cell Biol. 1986 Apr; 102(4):1320-4. PMID: 3082891.
    Citations: 30     Fields:    Translation:HumansCells
  118. Wagner DD, Mayadas T, Urban-Pickering M, Lewis BH, Marder VJ. Inhibition of disulfide bonding of von Willebrand protein by monensin results in small, functionally defective multimers. J Cell Biol. 1985 Jul; 101(1):112-20. PMID: 3924917.
    Citations: 6     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.