Harvard Catalyst Profiles

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Tanya Mayadas, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21AI154930 (MAYADAS, TANYA N) Jun 3, 2020 - May 31, 2022
    NIH/NIAID
    Glycoengineering IgA1 in IgA nephropathy
    Role: Principal Investigator
  2. R01AI152522 (MAYADAS, TANYA N) Feb 10, 2020 - Jan 31, 2025
    NIH/NIAID
    Neutrophil plasticity in autoimmune disease
    Role: Principal Investigator
  3. R21AI136527 (MAYADAS, TANYA N) Jan 22, 2018 - Dec 31, 2019
    NIH/NIAID
    Generation and Characterization of Mice with Tissue Specific Expression of Lupus Risk ITGAM SNPs
    Role: Principal Investigator
  4. R01DK099507 (MAYADAS, TANYA N) Apr 1, 2014 - Mar 31, 2019
    NIH/NIDDK
    TNFR2 Regulation of Leukocyte Recruitment in Glomerulonephritis
    Role: Principal Investigator
  5. R01DK077111 (MAYADAS, TANYA N.) Jun 7, 2007 - Aug 31, 2011
    NIH/NIDDK
    Endothelia mechanisms of leukocyte accumulation in glomerulonephritis
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Vorobyev A, Gupta Y, Sezin T, Koga H, Bartsch YC, Belheouane M, Künzel S, Sina C, Schilf P, Körber-Ahrens H, Beltsiou F, Lara Ernst A, Khil'chenko S, Al-Aasam H, Manz RA, Diehl S, Steinhaus M, Jascholt J, Kouki P, Boehncke WH, Mayadas TN, Zillikens D, Sadik CD, Nishi H, Ehlers M, Möller S, Bieber K, Baines JF, Ibrahim SM, Ludwig RJ. Gene-diet interactions associated with complex trait variation in an advanced intercross outbred mouse line. Nat Commun. 2019 09 10; 10(1):4097. PMID: 31506438.
    Citations:    
  2. Nishi H, Mayadas TN. Neutrophils in lupus nephritis. Curr Opin Rheumatol. 2019 03; 31(2):193-200. PMID: 30540580.
    Citations:    Fields:    
  3. Saggu G, Okubo K, Chen Y, Vattepu R, Tsuboi N, Rosetti F, Cullere X, Washburn N, Tahir S, Rosado AM, Holland SM, Anthony RM, Sen M, Zhu C, Mayadas TN. Cis interaction between sialylated Fc?RIIA and the aI-domain of Mac-1 limits antibody-mediated neutrophil recruitment. Nat Commun. 2018 11 29; 9(1):5058. PMID: 30498196.
    Citations:    Fields:    Translation:HumansAnimalsCells
  4. Chen B, Vousden KA, Naiman B, Turman S, Sun H, Wang S, Vinall LMK, Kemp BP, Kasturiangan S, Rees DG, Grant E, Hinrichs MJ, Eck S, DiGiandomenico A, Jack Borrok M, Ly N, Xiong X, Gonzalez C, Morehouse C, Wang Y, Zhou Y, Cann J, Zhao W, Koelkebeck H, Okubo K, Mayadas TN, Howe D, Griffiths J, Kolbeck R, Herbst R, Sims GP. Humanised effector-null Fc?RIIA antibody inhibits immune complex-mediated proinflammatory responses. Ann Rheum Dis. 2019 02; 78(2):228-237. PMID: 30459279.
    Citations:    Fields:    
  5. Okubo K, Kurosawa M, Kamiya M, Urano Y, Suzuki A, Yamamoto K, Hase K, Homma K, Sasaki J, Miyauchi H, Hoshino T, Hayashi M, Mayadas TN, Hirahashi J. Macrophage extracellular trap formation promoted by platelet activation is a key mediator of rhabdomyolysis-induced acute kidney injury. Nat Med. 2018 02; 24(2):232-238. PMID: 29309057.
    Citations: 5     Fields:    
  6. Nishi H, Furuhashi K, Cullere X, Saggu G, Miller MJ, Chen Y, Rosetti F, Hamilton SL, Yang L, Pittman SP, Liao J, Herter JM, Berry JC, DeAngelo DJ, Zhu C, Tsokos GC, Mayadas TN. Neutrophil Fc?RIIA promotes IgG-mediated glomerular neutrophil capture via Abl/Src kinases. J Clin Invest. 2017 Oct 02; 127(10):3810-3826. PMID: 28891817.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  7. Gordon RA, Herter JM, Rosetti F, Campbell AM, Nishi H, Kashgarian M, Bastacky SI, Marinov A, Nickerson KM, Mayadas TN, Shlomchik MJ. Lupus and proliferative nephritis are PAD4 independent in murine models. JCI Insight. 2017 May 18; 2(10). PMID: 28515361.
    Citations: 3     Fields:    
  8. Azcutia V, Bassil R, Herter JM, Engelbertsen D, Newton G, Autio A, Mayadas T, Lichtman AH, Khoury SJ, Parkos CA, Elyaman W, Luscinskas FW. Defects in CD4+ T cell LFA-1 integrin-dependent adhesion and proliferation protect Cd47-/- mice from EAE. J Leukoc Biol. 2017 02; 101(2):493-505. PMID: 27965383.
    Citations:    Fields:    Translation:HumansAnimalsCellsPHPublic Health
  9. Yoshida N, Comte D, Mizui M, Otomo K, Rosetti F, Mayadas TN, Crispín JC, Bradley SJ, Koga T, Kono M, Karampetsou MP, Kyttaris VC, Tenbrock K, Tsokos GC. ICER is requisite for Th17 differentiation. Nat Commun. 2016 Sep 29; 7:12993. PMID: 27680869.
    Citations: 7     Fields:    
  10. Okubo K, Kamiya M, Urano Y, Nishi H, Herter JM, Mayadas T, Hirohama D, Suzuki K, Kawakami H, Tanaka M, Kurosawa M, Kagaya S, Hishikawa K, Nangaku M, Fujita T, Hayashi M, Hirahashi J. Lactoferrin Suppresses Neutrophil Extracellular Traps Release in Inflammation. EBioMedicine. 2016 Aug; 10:204-15. PMID: 27453322.
    Citations: 9     Fields:    Translation:HumansCells
  11. Li X, Cullere X, Nishi H, Saggu G, Durand E, Mansour MK, Tam JM, Song XY, Lin X, Vyas JM, Mayadas T. PKC-d activation in neutrophils promotes fungal clearance. J Leukoc Biol. 2016 09; 100(3):581-8. PMID: 26965632.
    Citations: 5     Fields:    Translation:AnimalsCells
  12. Buscher K, Wang H, Zhang X, Striewski P, Wirth B, Saggu G, Lütke-Enking S, Mayadas TN, Ley K, Sorokin L, Song J. Protection from septic peritonitis by rapid neutrophil recruitment through omental high endothelial venules. Nat Commun. 2016 Mar 04; 7:10828. PMID: 26940548.
    Citations: 6     Fields:    Translation:AnimalsCells
  13. Ernandez T, Mayadas TN. The Changing Landscape of Renal Inflammation. Trends Mol Med. 2016 Feb; 22(2):151-163. PMID: 26778189.
    Citations: 2     Fields:    Translation:HumansCells
  14. Rosetti F, Mayadas TN. The many faces of Mac-1 in autoimmune disease. Immunol Rev. 2016 Jan; 269(1):175-93. PMID: 26683153.
    Citations: 14     Fields:    Translation:HumansAnimals
  15. Herter JM, Grabie N, Cullere X, Azcutia V, Rosetti F, Bennett P, Herter-Sprie GS, Elyaman W, Luscinskas FW, Lichtman AH, Mayadas TN. AKAP9 regulates activation-induced retention of T lymphocytes at sites of inflammation. Nat Commun. 2015 Dec 18; 6:10182. PMID: 26680259.
    Citations: 4     Fields:    Translation:AnimalsCells
  16. Venkatesh D, Mruk D, Herter JM, Cullere X, Chojnacka K, Cheng CY, Mayadas TN. AKAP9, a Regulator of Microtubule Dynamics, Contributes to Blood-Testis Barrier Function. Am J Pathol. 2016 Feb; 186(2):270-84. PMID: 26687990.
    Citations: 3     Fields:    Translation:AnimalsCells
  17. Cullere X, Plovie E, Bennett PM, MacRae CA, Mayadas TN. The cerebral cavernous malformation proteins CCM2L and CCM2 prevent the activation of the MAP kinase MEKK3. Proc Natl Acad Sci U S A. 2015 Nov 17; 112(46):14284-9. PMID: 26540726.
    Citations: 10     Fields:    Translation:AnimalsCells
  18. Batal I, De Serres SA, Safa K, Bijol V, Ueno T, Onozato ML, Iafrate AJ, Herter JM, Lichtman AH, Mayadas TN, Guleria I, Rennke HG, Najafian N, Chandraker A. Dendritic Cells in Kidney Transplant Biopsy Samples Are Associated with T Cell Infiltration and Poor Allograft Survival. J Am Soc Nephrol. 2015 Dec; 26(12):3102-13. PMID: 25855773.
    Citations: 7     Fields:    Translation:HumansCells
  19. Rosetti F, Chen Y, Sen M, Thayer E, Azcutia V, Herter JM, Luscinskas FW, Cullere X, Zhu C, Mayadas TN. A Lupus-Associated Mac-1 Variant Has Defects in Integrin Allostery and Interaction with Ligands under Force. Cell Rep. 2015 Mar 17; 10(10):1655-1664. PMID: 25772353.
    Citations: 9     Fields:    
  20. Al-Lamki RS, Mayadas TN. TNF receptors: signaling pathways and contribution to renal dysfunction. Kidney Int. 2015 Feb; 87(2):281-96. PMID: 25140911.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  21. Ganesan S, Rathinam VAK, Bossaller L, Army K, Kaiser WJ, Mocarski ES, Dillon CP, Green DR, Mayadas TN, Levitz SM, Hise AG, Silverman N, Fitzgerald KA. Caspase-8 modulates dectin-1 and complement receptor 3-driven IL-1ß production in response to ß-glucans and the fungal pathogen, Candida albicans. J Immunol. 2014 Sep 01; 193(5):2519-2530. PMID: 25063877.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  22. Herter JM, Mayadas TN. Midkine, a middle manager of ß2 integrins. Blood. 2014 Mar 20; 123(12):1777-9. PMID: 24652961.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  23. Mayadas TN, Cullere X, Lowell CA. The multifaceted functions of neutrophils. Annu Rev Pathol. 2014; 9:181-218. PMID: 24050624.
    Citations: 136     Fields:    Translation:HumansAnimalsCells
  24. Kannan L, Kis-Toth K, Yoshiya K, Thai TH, Sehrawat S, Mayadas TN, Dalle Lucca JJ, Tsokos GC. R-spondin3 prevents mesenteric ischemia/reperfusion-induced tissue damage by tightening endothelium and preventing vascular leakage. Proc Natl Acad Sci U S A. 2013 Aug 27; 110(35):14348-53. PMID: 23942120.
    Citations: 6     Fields:    Translation:AnimalsCells
  25. Adams WJ, Zhang Y, Cloutier J, Kuchimanchi P, Newton G, Sehrawat S, Aird WC, Mayadas TN, Luscinskas FW, García-Cardeña G. Functional vascular endothelium derived from human induced pluripotent stem cells. Stem Cell Reports. 2013; 1(2):105-13. PMID: 24052946.
    Citations: 40     Fields:    Translation:HumansCells
  26. Venkatesh D, Ernandez T, Rosetti F, Batal I, Cullere X, Luscinskas FW, Zhang Y, Stavrakis G, García-Cardeña G, Horwitz BH, Mayadas TN. Endothelial TNF receptor 2 induces IRF1 transcription factor-dependent interferon-ß autocrine signaling to promote monocyte recruitment. Immunity. 2013 May 23; 38(5):1025-37. PMID: 23623383.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  27. Pisitkun P, Ha HL, Wang H, Claudio E, Tivy CC, Zhou H, Mayadas TN, Illei GG, Siebenlist U. Interleukin-17 cytokines are critical in development of fatal lupus glomerulonephritis. Immunity. 2012 Dec 14; 37(6):1104-15. PMID: 23123062.
    Citations: 39     Fields:    Translation:AnimalsCells
  28. Chen K, Nishi H, Travers R, Tsuboi N, Martinod K, Wagner DD, Stan R, Croce K, Mayadas TN. Endocytosis of soluble immune complexes leads to their clearance by Fc?RIIIB but induces neutrophil extracellular traps via Fc?RIIA in vivo. Blood. 2012 Nov 22; 120(22):4421-31. PMID: 22955924.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  29. Rosetti F, Tsuboi N, Chen K, Nishi H, Ernandez T, Sethi S, Croce K, Stavrakis G, Alcocer-Varela J, Gómez-Martin D, van Rooijen N, Kyttaris VC, Lichtman AH, Tsokos GC, Mayadas TN. Human lupus serum induces neutrophil-mediated organ damage in mice that is enabled by Mac-1 deficiency. J Immunol. 2012 Oct 01; 189(7):3714-23. PMID: 22933624.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  30. Azcutia V, Stefanidakis M, Tsuboi N, Mayadas T, Croce KJ, Fukuda D, Aikawa M, Newton G, Luscinskas FW. Endothelial CD47 promotes vascular endothelial-cadherin tyrosine phosphorylation and participates in T cell recruitment at sites of inflammation in vivo. J Immunol. 2012 Sep 01; 189(5):2553-62. PMID: 22815286.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  31. Fu H, Liu B, Frost JL, Hong S, Jin M, Ostaszewski B, Shankar GM, Costantino IM, Carroll MC, Mayadas TN, Lemere CA. Complement component C3 and complement receptor type 3 contribute to the phagocytosis and clearance of fibrillar Aß by microglia. Glia. 2012 May; 60(6):993-1003. PMID: 22438044.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  32. Crispín JC, Apostolidis SA, Rosetti F, Keszei M, Wang N, Terhorst C, Mayadas TN, Tsokos GC. Cutting edge: protein phosphatase 2A confers susceptibility to autoimmune disease through an IL-17-dependent mechanism. J Immunol. 2012 Apr 15; 188(8):3567-71. PMID: 22422882.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  33. Niewczas MA, Gohda T, Skupien J, Smiles AM, Walker WH, Rosetti F, Cullere X, Eckfeldt JH, Doria A, Mayadas TN, Warram JH, Krolewski AS. Circulating TNF receptors 1 and 2 predict ESRD in type 2 diabetes. J Am Soc Nephrol. 2012 Mar; 23(3):507-15. PMID: 22266663.
    Citations: 111     Fields:    Translation:HumansCells
  34. Gohda T, Niewczas MA, Ficociello LH, Walker WH, Skupien J, Rosetti F, Cullere X, Johnson AC, Crabtree G, Smiles AM, Mayadas TN, Warram JH, Krolewski AS. Circulating TNF receptors 1 and 2 predict stage 3 CKD in type 1 diabetes. J Am Soc Nephrol. 2012 Mar; 23(3):516-24. PMID: 22266664.
    Citations: 91     Fields:    Translation:HumansCells
  35. Lowell CA, Mayadas TN. Overview: studying integrins in vivo. Methods Mol Biol. 2012; 757:369-97. PMID: 21909923.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  36. Li X, Utomo A, Cullere X, Choi MM, Milner DA, Venkatesh D, Yun SH, Mayadas TN. The ß-glucan receptor Dectin-1 activates the integrin Mac-1 in neutrophils via Vav protein signaling to promote Candida albicans clearance. Cell Host Microbe. 2011 Dec 15; 10(6):603-15. PMID: 22177564.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  37. Tsuboi N, Ernandez T, Li X, Nishi H, Cullere X, Mekala D, Hazen M, Köhl J, Lee DM, Mayadas TN. Regulation of human neutrophil Fc? receptor IIa by C5a receptor promotes inflammatory arthritis in mice. Arthritis Rheum. 2011 Feb; 63(2):467-78. PMID: 21280001.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  38. Sehrawat S, Ernandez T, Cullere X, Takahashi M, Ono Y, Komarova Y, Mayadas TN. AKAP9 regulation of microtubule dynamics promotes Epac1-induced endothelial barrier properties. Blood. 2011 Jan 13; 117(2):708-18. PMID: 20952690.
    Citations: 22     Fields:    Translation:HumansCells
  39. Mayadas TN, Rosetti F, Ernandez T, Sethi S. Neutrophils: game changers in glomerulonephritis? Trends Mol Med. 2010 Aug; 16(8):368-78. PMID: 20667782.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  40. Mayadas TN, Tsokos GC, Tsuboi N. Mechanisms of immune complex-mediated neutrophil recruitment and tissue injury. Circulation. 2009 Nov 17; 120(20):2012-24. PMID: 19917895.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  41. Hirahashi J, Hishikawa K, Kaname S, Tsuboi N, Wang Y, Simon DI, Stavrakis G, Shimosawa T, Xiao L, Nagahama Y, Suzuki K, Fujita T, Mayadas TN. Mac-1 (CD11b/CD18) links inflammation and thrombosis after glomerular injury. Circulation. 2009 Sep 29; 120(13):1255-65. PMID: 19752320.
    Citations: 31     Fields:    Translation:AnimalsCells
  42. Ernandez T, Mayadas TN. Immunoregulatory role of TNFalpha in inflammatory kidney diseases. Kidney Int. 2009 Aug; 76(3):262-76. PMID: 19436333.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  43. Lichtnekert J, Vielhauer V, Zecher D, Kulkarni OP, Clauss S, Segerer S, Hornung V, Mayadas TN, Beutler B, Akira S, Anders HJ. Trif is not required for immune complex glomerulonephritis: dying cells activate mesangial cells via Tlr2/Myd88 rather than Tlr3/Trif. Am J Physiol Renal Physiol. 2009 Apr; 296(4):F867-74. PMID: 19158348.
    Citations: 16     Fields:    Translation:AnimalsCells
  44. Alcaide P, Newton G, Auerbach S, Sehrawat S, Mayadas TN, Golan DE, Yacono P, Vincent P, Kowalczyk A, Luscinskas FW. p120-Catenin regulates leukocyte transmigration through an effect on VE-cadherin phosphorylation. Blood. 2008 Oct 01; 112(7):2770-9. PMID: 18641366.
    Citations: 50     Fields:    Translation:HumansCells
  45. Tsuboi N, Asano K, Lauterbach M, Mayadas TN. Human neutrophil Fcgamma receptors initiate and play specialized nonredundant roles in antibody-mediated inflammatory diseases. Immunity. 2008 Jun; 28(6):833-46. PMID: 18538590.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  46. Utomo A, Hirahashi J, Mekala D, Asano K, Glogauer M, Cullere X, Mayadas TN. Requirement for Vav proteins in post-recruitment neutrophil cytotoxicity in IgG but not complement C3-dependent injury. J Immunol. 2008 May 01; 180(9):6279-87. PMID: 18424751.
    Citations: 8     Fields:    Translation:AnimalsCells
  47. Lauterbach M, O'Donnell P, Asano K, Mayadas TN. Role of TNF priming and adhesion molecules in neutrophil recruitment to intravascular immune complexes. J Leukoc Biol. 2008 Jun; 83(6):1423-30. PMID: 18372339.
    Citations: 17     Fields:    Translation:AnimalsCells
  48. Cullere X, Lauterbach M, Tsuboi N, Mayadas TN. Neutrophil-selective CD18 silencing using RNA interference in vivo. Blood. 2008 Apr 01; 111(7):3591-8. PMID: 18216298.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  49. Sehrawat S, Cullere X, Patel S, Italiano J, Mayadas TN. Role of Epac1, an exchange factor for Rap GTPases, in endothelial microtubule dynamics and barrier function. Mol Biol Cell. 2008 Mar; 19(3):1261-70. PMID: 18172027.
    Citations: 50     Fields:    Translation:HumansCells
  50. Menke J, Lucas JA, Zeller GC, Keir ME, Huang XR, Tsuboi N, Mayadas TN, Lan HY, Sharpe AH, Kelley VR. Programmed death 1 ligand (PD-L) 1 and PD-L2 limit autoimmune kidney disease: distinct roles. J Immunol. 2007 Dec 01; 179(11):7466-77. PMID: 18025191.
    Citations: 20     Fields:    Translation:AnimalsCells
  51. Dole VS, Bergmeier W, Patten IS, Hirahashi J, Mayadas TN, Wagner DD. PSGL-1 regulates platelet P-selectin-mediated endothelial activation and shedding of P-selectin from activated platelets. Thromb Haemost. 2007 Oct; 98(4):806-12. PMID: 17938805.
    Citations: 14     Fields:    Translation:AnimalsCells
  52. Ghandour H, Cullere X, Alvarez A, Luscinskas FW, Mayadas TN. Essential role for Rap1 GTPase and its guanine exchange factor CalDAG-GEFI in LFA-1 but not VLA-4 integrin mediated human T-cell adhesion. Blood. 2007 Nov 15; 110(10):3682-90. PMID: 17702895.
    Citations: 43     Fields:    Translation:HumansCells
  53. Sisco M, Chao JD, Kim I, Mogford JE, Mayadas TN, Mustoe TA. Delayed wound healing in Mac-1-deficient mice is associated with normal monocyte recruitment. Wound Repair Regen. 2007 Jul-Aug; 15(4):566-71. PMID: 17650101.
    Citations: 4     Fields:    Translation:AnimalsCells
  54. Vielhauer V, Mayadas TN. Functions of TNF and its receptors in renal disease: distinct roles in inflammatory tissue injury and immune regulation. Semin Nephrol. 2007 May; 27(3):286-308. PMID: 17533007.
    Citations: 29     Fields:    Translation:HumansAnimals
  55. Sircar M, Bradfield PF, Aurrand-Lions M, Fish RJ, Alcaide P, Yang L, Newton G, Lamont D, Sehrawat S, Mayadas T, Liang TW, Parkos CA, Imhof BA, Luscinskas FW. Neutrophil transmigration under shear flow conditions in vitro is junctional adhesion molecule-C independent. J Immunol. 2007 May 01; 178(9):5879-87. PMID: 17442972.
    Citations: 14     Fields:    Translation:AnimalsCells
  56. Utomo A, Cullere X, Glogauer M, Swat W, Mayadas TN. Vav proteins in neutrophils are required for FcgammaR-mediated signaling to Rac GTPases and nicotinamide adenine dinucleotide phosphate oxidase component p40(phox). J Immunol. 2006 Nov 01; 177(9):6388-97. PMID: 17056570.
    Citations: 31     Fields:    Translation:AnimalsCells
  57. Hirahashi J, Mekala D, Van Ziffle J, Xiao L, Saffaripour S, Wagner DD, Shapiro SD, Lowell C, Mayadas TN. Mac-1 signaling via Src-family and Syk kinases results in elastase-dependent thrombohemorrhagic vasculopathy. Immunity. 2006 Aug; 25(2):271-83. PMID: 16872848.
    Citations: 45     Fields:    Translation:AnimalsCells
  58. Liu Z, Zhao M, Li N, Diaz LA, Mayadas TN. Differential roles for beta2 integrins in experimental autoimmune bullous pemphigoid. Blood. 2006 Feb 01; 107(3):1063-9. PMID: 16234355.
    Citations: 9     Fields:    Translation:AnimalsCells
  59. Hochegger K, Siebenhaar F, Vielhauer V, Heininger D, Mayadas TN, Mayer G, Maurer M, Rosenkranz AR. Role of mast cells in experimental anti-glomerular basement membrane glomerulonephritis. Eur J Immunol. 2005 Oct; 35(10):3074-82. PMID: 16180252.
    Citations: 28     Fields:    Translation:AnimalsCells
  60. Mayadas TN, Cullere X. Neutrophil beta2 integrins: moderators of life or death decisions. Trends Immunol. 2005 Jul; 26(7):388-95. PMID: 15922663.
    Citations: 74     Fields:    Translation:HumansAnimalsCells
  61. Vielhauer V, Stavrakis G, Mayadas TN. Renal cell-expressed TNF receptor 2, not receptor 1, is essential for the development of glomerulonephritis. J Clin Invest. 2005 May; 115(5):1199-209. PMID: 15841213.
    Citations: 37     Fields:    Translation:AnimalsCells
  62. Stokol T, O'Donnell P, Xiao L, Knight S, Stavrakis G, Botto M, von Andrian UH, Mayadas TN. C1q governs deposition of circulating immune complexes and leukocyte Fcgamma receptors mediate subsequent neutrophil recruitment. J Exp Med. 2004 Oct 04; 200(7):835-46. PMID: 15466618.
    Citations: 27     Fields:    Translation:AnimalsCells
  63. Cullere X, Shaw SK, Andersson L, Hirahashi J, Luscinskas FW, Mayadas TN. Regulation of vascular endothelial barrier function by Epac, a cAMP-activated exchange factor for Rap GTPase. Blood. 2005 Mar 01; 105(5):1950-5. PMID: 15374886.
    Citations: 145     Fields:    Translation:HumansCells
  64. Embury SH, Matsui NM, Ramanujam S, Mayadas TN, Noguchi CT, Diwan BA, Mohandas N, Cheung AT. The contribution of endothelial cell P-selectin to the microvascular flow of mouse sickle erythrocytes in vivo. Blood. 2004 Nov 15; 104(10):3378-85. PMID: 15271798.
    Citations: 29     Fields:    Translation:AnimalsCells
  65. Gakidis MA, Cullere X, Olson T, Wilsbacher JL, Zhang B, Moores SL, Ley K, Swat W, Mayadas T, Brugge JS. Vav GEFs are required for beta2 integrin-dependent functions of neutrophils. J Cell Biol. 2004 Jul 19; 166(2):273-82. PMID: 15249579.
    Citations: 71     Fields:    Translation:AnimalsCells
  66. Combes V, Rosenkranz AR, Redard M, Pizzolato G, Lepidi H, Vestweber D, Mayadas TN, Grau GE. Pathogenic role of P-selectin in experimental cerebral malaria: importance of the endothelial compartment. Am J Pathol. 2004 Mar; 164(3):781-6. PMID: 14982832.
    Citations: 16     Fields:    Translation:AnimalsCells
  67. Hochegger K, Knight S, Hugo C, Mayer G, Lawler J, Mayadas TN, Rosenkranz AR. Role of thrombospondin-1 in the autologous phase of an accelerated model of anti-glomerular basement membrane glomerulonephritis. Nephron Exp Nephrol. 2004; 96(2):e31-8. PMID: 14988590.
    Citations: 2     Fields:    Translation:Animals
  68. Zhang B, Hirahashi J, Cullere X, Mayadas TN. Elucidation of molecular events leading to neutrophil apoptosis following phagocytosis: cross-talk between caspase 8, reactive oxygen species, and MAPK/ERK activation. J Biol Chem. 2003 Aug 01; 278(31):28443-54. PMID: 12736263.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  69. Hoffmeister KM, Felbinger TW, Falet H, Denis CV, Bergmeier W, Mayadas TN, von Andrian UH, Wagner DD, Stossel TP, Hartwig JH. The clearance mechanism of chilled blood platelets. Cell. 2003 Jan 10; 112(1):87-97. PMID: 12526796.
    Citations: 76     Fields:    Translation:HumansAnimalsCells
  70. Henneke P, Takeuchi O, Malley R, Lien E, Ingalls RR, Freeman MW, Mayadas T, Nizet V, Akira S, Kasper DL, Golenbock DT. Cellular activation, phagocytosis, and bactericidal activity against group B streptococcus involve parallel myeloid differentiation factor 88-dependent and independent signaling pathways. J Immunol. 2002 Oct 01; 169(7):3970-7. PMID: 12244198.
    Citations: 56     Fields:    Translation:HumansAnimalsCells
  71. Sethi S, Ziouzenkova O, Ni H, Wagner DD, Plutzky J, Mayadas TN. Oxidized omega-3 fatty acids in fish oil inhibit leukocyte-endothelial interactions through activation of PPAR alpha. Blood. 2002 Aug 15; 100(4):1340-6. PMID: 12149216.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  72. Coxon A, Cullere X, Knight S, Sethi S, Wakelin MW, Stavrakis G, Luscinskas FW, Mayadas TN. Fc gamma RIII mediates neutrophil recruitment to immune complexes. a mechanism for neutrophil accumulation in immune-mediated inflammation. Immunity. 2001 Jun; 14(6):693-704. PMID: 11420040.
    Citations: 65     Fields:    Translation:HumansAnimalsCells
  73. Niederman R, Westernoff T, Lee C, Mark LL, Kawashima N, Ullman-Culler M, Dewhirst FE, Paster BJ, Wagner DD, Mayadas T, Hynes RO, Stashenko P. Infection-mediated early-onset periodontal disease in P/E-selectin-deficient mice. J Clin Periodontol. 2001 Jun; 28(6):569-75. PMID: 11350525.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  74. van Spriel AB, Leusen JH, van Egmond M, Dijkman HB, Assmann KJ, Mayadas TN, van de Winkel JG. Mac-1 (CD11b/CD18) is essential for Fc receptor-mediated neutrophil cytotoxicity and immunologic synapse formation. Blood. 2001 Apr 15; 97(8):2478-86. PMID: 11290613.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  75. Ren Y, Stuart L, Lindberg FP, Rosenkranz AR, Chen Y, Mayadas TN, Savill J. Nonphlogistic clearance of late apoptotic neutrophils by macrophages: efficient phagocytosis independent of beta 2 integrins. J Immunol. 2001 Apr 01; 166(7):4743-50. PMID: 11254736.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  76. Perera PY, Mayadas TN, Takeuchi O, Akira S, Zaks-Zilberman M, Goyert SM, Vogel SN. CD11b/CD18 acts in concert with CD14 and Toll-like receptor (TLR) 4 to elicit full lipopolysaccharide and taxol-inducible gene expression. J Immunol. 2001 Jan 01; 166(1):574-81. PMID: 11123339.
    Citations: 82     Fields:    Translation:AnimalsCells
  77. Barkalow FJ, Barkalow KL, Mayadas TN. Dimerization of P-selectin in platelets and endothelial cells. Blood. 2000 Nov 01; 96(9):3070-7. PMID: 11049986.
    Citations: 12     Fields:    Translation:HumansCells
  78. Rosenkranz AR, Knight S, Sethi S, Alexander SI, Cotran RS, Mayadas TN. Regulatory interactions of alphabeta and gammadelta T cells in glomerulonephritis. Kidney Int. 2000 Sep; 58(3):1055-66. PMID: 10972670.
    Citations: 13     Fields:    Translation:AnimalsCells
  79. Yan J, Vetvicka V, Xia Y, Hanikýrová M, Mayadas TN, Ross GD. Critical role of Kupffer cell CR3 (CD11b/CD18) in the clearance of IgM-opsonized erythrocytes or soluble beta-glucan. Immunopharmacology. 2000 Jan; 46(1):39-54. PMID: 10665778.
    Citations: 18     Fields:    Translation:AnimalsCells
  80. Coxon A, Tang T, Mayadas TN. Cytokine-activated endothelial cells delay neutrophil apoptosis in vitro and in vivo. A role for granulocyte/macrophage colony-stimulating factor. J Exp Med. 1999 Oct 04; 190(7):923-34. PMID: 10510082.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  81. Yan J, Vetvicka V, Xia Y, Coxon A, Carroll MC, Mayadas TN, Ross GD. Beta-glucan, a "specific" biologic response modifier that uses antibodies to target tumors for cytotoxic recognition by leukocyte complement receptor type 3 (CD11b/CD18). J Immunol. 1999 Sep 15; 163(6):3045-52. PMID: 10477568.
    Citations: 23     Fields:    Translation:AnimalsCells
  82. Bhat N, Perera PY, Carboni JM, Blanco J, Golenbock DT, Mayadas TN, Vogel SN. Use of a photoactivatable taxol analogue to identify unique cellular targets in murine macrophages: identification of murine CD18 as a major taxol-binding protein and a role for Mac-1 in taxol-induced gene expression. J Immunol. 1999 Jun 15; 162(12):7335-42. PMID: 10358184.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  83. van Egmond M, van Vuuren AJ, Morton HC, van Spriel AB, Shen L, Hofhuis FM, Saito T, Mayadas TN, Verbeek JS, van de Winkel JG. Human immunoglobulin A receptor (FcalphaRI, CD89) function in transgenic mice requires both FcR gamma chain and CR3 (CD11b/CD18). Blood. 1999 Jun 15; 93(12):4387-94. PMID: 10361137.
    Citations: 20     Fields:    Translation:HumansAnimals
  84. Mayadas TN, Rosenkranz A, Cotran RS. Glomerular inflammation: use of genetically deficient mice to elucidate the roles of leukocyte adhesion molecules and Fc-gamma receptors in vivo. Curr Opin Nephrol Hypertens. 1999 May; 8(3):293-8. PMID: 10456259.
    Citations: 5     Fields:    Translation:AnimalsCells
  85. Rosenkranz AR, Mendrick DL, Cotran RS, Mayadas TN. P-selectin deficiency exacerbates experimental glomerulonephritis: a protective role for endothelial P-selectin in inflammation. J Clin Invest. 1999 Mar; 103(5):649-59. PMID: 10074481.
    Citations: 39     Fields:    Translation:Animals
  86. Rosenkranz AR, Mayadas TN. Leukocyte-endothelial cell interactions - lessons from knockout mice. Exp Nephrol. 1999 Mar-Apr; 7(2):125-36. PMID: 10213866.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  87. Xia Y, Vetvicka V, Yan J, Hanikýrová M, Mayadas T, Ross GD. The beta-glucan-binding lectin site of mouse CR3 (CD11b/CD18) and its function in generating a primed state of the receptor that mediates cytotoxic activation in response to iC3b-opsonized target cells. J Immunol. 1999 Feb 15; 162(4):2281-90. PMID: 9973505.
    Citations: 62     Fields:    Translation:AnimalsCells
  88. Soriano SG, Coxon A, Wang YF, Frosch MP, Lipton SA, Hickey PR, Mayadas TN. Mice deficient in Mac-1 (CD11b/CD18) are less susceptible to cerebral ischemia/reperfusion injury. Stroke. 1999 Jan; 30(1):134-9. PMID: 9880401.
    Citations: 53     Fields:    Translation:AnimalsCells
  89. Rosenkranz AR, Coxon A, Maurer M, Gurish MF, Austen KF, Friend DS, Galli SJ, Mayadas TN. Impaired mast cell development and innate immunity in Mac-1 (CD11b/CD18, CR3)-deficient mice. J Immunol. 1998 Dec 15; 161(12):6463-7. PMID: 9862668.
    Citations: 30     Fields:    Translation:AnimalsCells
  90. Hartwell DW, Mayadas TN, Berger G, Frenette PS, Rayburn H, Hynes RO, Wagner DD. Role of P-selectin cytoplasmic domain in granular targeting in vivo and in early inflammatory responses. J Cell Biol. 1998 Nov 16; 143(4):1129-41. PMID: 9817767.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  91. Tang T, Rosenkranz A, Assmann KJ, Goodman MJ, Gutierrez-Ramos JC, Carroll MC, Cotran RS, Mayadas TN. A role for Mac-1 (CDIIb/CD18) in immune complex-stimulated neutrophil function in vivo: Mac-1 deficiency abrogates sustained Fcgamma receptor-dependent neutrophil adhesion and complement-dependent proteinuria in acute glomerulonephritis. J Exp Med. 1997 Dec 01; 186(11):1853-63. PMID: 9382884.
    Citations: 54     Fields:    Translation:AnimalsCells
  92. Dong ZM, Gutierrez-Ramos JC, Coxon A, Mayadas TN, Wagner DD. A new class of obesity genes encodes leukocyte adhesion receptors. Proc Natl Acad Sci U S A. 1997 Jul 08; 94(14):7526-30. PMID: 9207125.
    Citations: 23     Fields:    Translation:Animals
  93. Subramaniam M, Saffaripour S, Van De Water L, Frenette PS, Mayadas TN, Hynes RO, Wagner DD. Role of endothelial selectins in wound repair. Am J Pathol. 1997 May; 150(5):1701-9. PMID: 9137094.
    Citations: 29     Fields:    Translation:AnimalsCells
  94. Johnson RC, Chapman SM, Dong ZM, Ordovas JM, Mayadas TN, Herz J, Hynes RO, Schaefer EJ, Wagner DD. Absence of P-selectin delays fatty streak formation in mice. J Clin Invest. 1997 Mar 01; 99(5):1037-43. PMID: 9062362.
    Citations: 45     Fields:    Translation:AnimalsCells
  95. Barkalow FJ, Goodman MJ, Gerritsen ME, Mayadas TN. Brain endothelium lack one of two pathways of P-selectin-mediated neutrophil adhesion. Blood. 1996 Dec 15; 88(12):4585-93. PMID: 8977250.
    Citations: 21     Fields:    Translation:AnimalsCells
  96. Coxon A, Rieu P, Barkalow FJ, Askari S, Sharpe AH, von Andrian UH, Arnaout MA, Mayadas TN. A novel role for the beta 2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation. Immunity. 1996 Dec; 5(6):653-66. PMID: 8986723.
    Citations: 173     Fields:    Translation:HumansAnimalsCells
  97. Tang T, Frenette PS, Hynes RO, Wagner DD, Mayadas TN. Cytokine-induced meningitis is dramatically attenuated in mice deficient in endothelial selectins. J Clin Invest. 1996 Jun 01; 97(11):2485-90. PMID: 8647940.
    Citations: 23     Fields:    Translation:AnimalsCells
  98. Mayadas TN, Mendrick DL, Brady HR, Tang T, Papayianni A, Assmann KJ, Wagner DD, Hynes RO, Cotran RS. Acute passive anti-glomerular basement membrane nephritis in P-selectin-deficient mice. Kidney Int. 1996 May; 49(5):1342-9. PMID: 8731099.
    Citations: 14     Fields:    Translation:AnimalsCells
  99. Frenette PS, Mayadas TN, Rayburn H, Hynes RO, Wagner DD. Double knockout highlights value of endothelial selectins. Immunol Today. 1996 May; 17(5):205. PMID: 8991376.
    Citations: 2     Fields:    Translation:Animals
  100. Barkalow FJ, Goodman MJ, Mayadas TN. Cultured murine cerebral microvascular endothelial cells contain von Willebrand factor-positive Weibel-Palade bodies and support rapid cytokine-induced neutrophil adhesion. Microcirculation. 1996 Mar; 3(1):19-28. PMID: 8846268.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  101. Frenette PS, Mayadas TN, Rayburn H, Hynes RO, Wagner DD. Susceptibility to infection and altered hematopoiesis in mice deficient in both P- and E-selectins. Cell. 1996 Feb 23; 84(4):563-74. PMID: 8598043.
    Citations: 138     Fields:    Translation:AnimalsCells
  102. Pinsky DJ, Naka Y, Liao H, Oz MC, Wagner DD, Mayadas TN, Johnson RC, Hynes RO, Heath M, Lawson CA, Stern DM. Hypoxia-induced exocytosis of endothelial cell Weibel-Palade bodies. A mechanism for rapid neutrophil recruitment after cardiac preservation. J Clin Invest. 1996 Jan 15; 97(2):493-500. PMID: 8567972.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  103. Yamada S, Mayadas TN, Yuan F, Wagner DD, Hynes RO, Melder RJ, Jain RK. Rolling in P-selectin-deficient mice is reduced but not eliminated in the dorsal skin. Blood. 1995 Nov 01; 86(9):3487-92. PMID: 7579454.
    Citations: 7     Fields:    Translation:AnimalsCells
  104. Johnson RC, Mayadas TN, Frenette PS, Mebius RE, Subramaniam M, Lacasce A, Hynes RO, Wagner DD. Blood cell dynamics in P-selectin-deficient mice. Blood. 1995 Aug 01; 86(3):1106-14. PMID: 7542495.
    Citations: 26     Fields:    Translation:AnimalsCells
  105. Mayadas TN. Gene knockout on P-selectin: Its biology and function. Trends Cardiovasc Med. 1995 Jul-Aug; 5(4):149-57. PMID: 21232252.
    Citations: 3     Fields:    
  106. Subramaniam M, Saffaripour S, Watson SR, Mayadas TN, Hynes RO, Wagner DD. Reduced recruitment of inflammatory cells in a contact hypersensitivity response in P-selectin-deficient mice. J Exp Med. 1995 Jun 01; 181(6):2277-82. PMID: 7539046.
    Citations: 35     Fields:    Translation:AnimalsCells
  107. Mayadas TN, Johnson RC, Rayburn H, Hynes RO, Wagner DD. Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice. Cell. 1993 Aug 13; 74(3):541-54. PMID: 7688665.
    Citations: 232     Fields:    Translation:AnimalsCells
  108. Mayadas TN, Wagner DD. Vicinal cysteines in the prosequence play a role in von Willebrand factor multimer assembly. Proc Natl Acad Sci U S A. 1992 Apr 15; 89(8):3531-5. PMID: 1565649.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  109. Wagner DD, Saffaripour S, Bonfanti R, Sadler JE, Cramer EM, Chapman B, Mayadas TN. Induction of specific storage organelles by von Willebrand factor propolypeptide. Cell. 1991 Jan 25; 64(2):403-13. PMID: 1988154.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  110. Mayadas TN, Wagner DD. von Willebrand factor biosynthesis and processing. Ann N Y Acad Sci. 1991; 614:153-66. PMID: 2024882.
    Citations: 9     Fields:    Translation:HumansCells
  111. Mayadas TN, Wagner DD. In vitro multimerization of von Willebrand factor is triggered by low pH. Importance of the propolypeptide and free sulfhydryls. J Biol Chem. 1989 Aug 15; 264(23):13497-503. PMID: 2788160.
    Citations: 21     Fields:    Translation:HumansCells
  112. Mayadas T, Wagner DD, Simpson PJ. von Willebrand factor biosynthesis and partitioning between constitutive and regulated pathways of secretion after thrombin stimulation. Blood. 1989 Feb 15; 73(3):706-11. PMID: 2783866.
    Citations: 7     Fields:    Translation:HumansCells
  113. Wagner DD, Mayadas T, Marder VJ. Initial glycosylation and acidic pH in the Golgi apparatus are required for multimerization of von Willebrand factor. J Cell Biol. 1986 Apr; 102(4):1320-4. PMID: 3082891.
    Citations: 25     Fields:    Translation:HumansCells
  114. Wagner DD, Mayadas T, Urban-Pickering M, Lewis BH, Marder VJ. Inhibition of disulfide bonding of von Willebrand protein by monensin results in small, functionally defective multimers. J Cell Biol. 1985 Jul; 101(1):112-20. PMID: 3924917.
    Citations: 6     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.