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Michael Costigan, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01NS074430 (COSTIGAN, MICHAEL) Jul 1, 2012 - Apr 30, 2017
    NIH/NINDS
    The mechanisms of action of T-lymphocytes in neuropathic pain
    Role: Principal Investigator
  2. R03NS052623 (COSTIGAN, MICHAEL) Jul 1, 2005 - Jun 30, 2007
    NIH/NINDS
    The genetic basis of pain sensitivity
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Davies AJ, Rinaldi S, Costigan M, Oh SB. Cytotoxic Immunity in Peripheral Nerve Injury and Pain. Front Neurosci. 2020; 14:142. PMID: 32153361.
    Citations:    
  2. Manion J, Khuong T, Harney D, Littleboy JB, Ruan T, Loo L, Costigan M, Larance M, Caron L, Neely GG. Human induced pluripotent stem cell-derived GABAergic interneuron transplants attenuate neuropathic pain. Pain. 2020 02; 161(2):379-387. PMID: 31972853.
    Citations:    Fields:    
  3. Fujita M, Scheffer DDL, Turnes BL, Cronin SJF, Latrémolière A, Costigan M, Woolf CJ, Latini A, Andrews NA. Sepiapterin Reductase Inhibition Leading to Selective Reduction of Inflammatory Joint Pain in Mice and Increased Urinary Sepiapterin Levels in Humans and Mice. Arthritis Rheumatol. 2020 01; 72(1):57-66. PMID: 31350812.
    Citations: 2     Fields:    Translation:HumansAnimals
  4. Calvo M, Davies AJ, Hébert HL, Weir GA, Chesler EJ, Finnerup NB, Levitt RC, Smith BH, Neely GG, Costigan M, Bennett DL. The Genetics of Neuropathic Pain from Model Organisms to Clinical Application. Neuron. 2019 11 20; 104(4):637-653. PMID: 31751545.
    Citations: 3     Fields:    Translation:HumansAnimals
  5. Bullock D, Jesuthasan A, González-Cano R, Costigan M. Reading and writing: the evolution of molecular pain genetics. Pain. 2019 10; 160(10):2177-2185. PMID: 31145218.
    Citations:    Fields:    Translation:HumansCells
  6. Cronin SJF, Seehus C, Weidinger A, Talbot S, Reissig S, Seifert M, Pierson Y, McNeill E, Longhi MS, Turnes BL, Kreslavsky T, Kogler M, Hoffmann D, Ticevic M, da Luz Scheffer D, Tortola L, Cikes D, Jais A, Rangachari M, Rao S, Paolino M, Novatchkova M, Aichinger M, Barrett L, Latremoliere A, Wirnsberger G, Lametschwandtner G, Busslinger M, Zicha S, Latini A, Robson SC, Waisman A, Andrews N, Costigan M, Channon KM, Weiss G, Kozlov AV, Tebbe M, Johnsson K, Woolf CJ, Penninger JM. Publisher Correction: The metabolite BH4 controls T cell proliferation in autoimmunity and cancer. Nature. 2019 Aug; 572(7769):E18. PMID: 31363232.
    Citations:    Fields:    
  7. Davies AJ, Kim HW, Gonzalez-Cano R, Choi J, Back SK, Roh SE, Johnson E, Gabriac M, Kim MS, Lee J, Lee JE, Kim YS, Bae YC, Kim SJ, Lee KM, Na HS, Riva P, Latremoliere A, Rinaldi S, Ugolini S, Costigan M, Oh SB. Natural Killer Cells Degenerate Intact Sensory Afferents following Nerve Injury. Cell. 2019 02 07; 176(4):716-728.e18. PMID: 30712871.
    Citations: 6     Fields:    Translation:AnimalsCells
  8. Cronin SJF, Seehus C, Weidinger A, Talbot S, Reissig S, Seifert M, Pierson Y, McNeill E, Longhi MS, Turnes BL, Kreslavsky T, Kogler M, Hoffmann D, Ticevic M, da Luz Scheffer D, Tortola L, Cikes D, Jais A, Rangachari M, Rao S, Paolino M, Novatchkova M, Aichinger M, Barrett L, Latremoliere A, Wirnsberger G, Lametschwandtner G, Busslinger M, Zicha S, Latini A, Robson SC, Waisman A, Andrews N, Costigan M, Channon KM, Weiss G, Kozlov AV, Tebbe M, Johnsson K, Woolf CJ, Penninger JM. The metabolite BH4 controls T cell proliferation in autoimmunity and cancer. Nature. 2018 11; 563(7732):564-568. PMID: 30405245.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  9. Huebner EA, Budel S, Jiang Z, Omura T, Ho TS, Barrett L, Merkel JS, Pereira LM, Andrews NA, Wang X, Singh B, Kapur K, Costigan M, Strittmatter SM, Woolf CJ. Diltiazem Promotes Regenerative Axon Growth. Mol Neurobiol. 2019 Jun; 56(6):3948-3957. PMID: 30232777.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  10. Sieberg CB, Taras C, Gomaa A, Nickerson C, Wong C, Ward C, Baskozos G, Bennett DLH, Ramirez JD, Themistocleous AC, Rice ASC, Shillo PR, Tesfaye S, Edwards RR, Andrews NA, Berde C, Costigan M. Neuropathic pain drives anxiety behavior in mice, results consistent with anxiety levels in diabetic neuropathy patients. Pain Rep. 2018 May; 3(3):e651. PMID: 29922743.
    Citations: 6     
  11. Gonzalez-Cano R, Boivin B, Bullock D, Cornelissen L, Andrews N, Costigan M. Up-Down Reader: An Open Source Program for Efficiently Processing 50% von Frey Thresholds. Front Pharmacol. 2018; 9:433. PMID: 29765323.
    Citations: 2     
  12. Cobos EJ, Nickerson CA, Gao F, Chandran V, Bravo-Caparrós I, González-Cano R, Riva P, Andrews NA, Latremoliere A, Seehus CR, Perazzoli G, Nieto FR, Joller N, Painter MW, Ma CHE, Omura T, Chesler EJ, Geschwind DH, Coppola G, Rangachari M, Woolf CJ, Costigan M. Mechanistic Differences in Neuropathic Pain Modalities Revealed by Correlating Behavior with Global Expression Profiling. Cell Rep. 2018 01 30; 22(5):1301-1312. PMID: 29386116.
    Citations: 21     Fields:    Translation:AnimalsCells
  13. Lisi V, Singh B, Giroux M, Guzman E, Painter MW, Cheng YC, Huebner E, Coppola G, Costigan M, Woolf CJ, Kosik KS. Enhanced Neuronal Regeneration in the CAST/Ei Mouse Strain Is Linked to Expression of Differentiation Markers after Injury. Cell Rep. 2017 08 01; 20(5):1136-1147. PMID: 28768198.
    Citations: 5     Fields:    Translation:AnimalsCells
  14. Browne LE, Latremoliere A, Lehnert BP, Grantham A, Ward C, Alexandre C, Costigan M, Michoud F, Roberson DP, Ginty DD, Woolf CJ. Time-Resolved Fast Mammalian Behavior Reveals the Complexity of Protective Pain Responses. Cell Rep. 2017 07 05; 20(1):89-98. PMID: 28683326.
    Citations: 3     Fields:    Translation:AnimalsCells
  15. Latremoliere A, Costigan M. Combining Human and Rodent Genetics to Identify New Analgesics. Neurosci Bull. 2018 Feb; 34(1):143-155. PMID: 28667479.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  16. Banno T, Omura T, Masaki N, Arima H, Xu D, Okamoto A, Costigan M, Latremoliere A, Matsuyama Y, Setou M. Arachidonic acid containing phosphatidylcholine increases due to microglial activation in ipsilateral spinal dorsal horn following spared sciatic nerve injury. PLoS One. 2017; 12(5):e0177595. PMID: 28542572.
    Citations: 2     Fields:    Translation:AnimalsCells
  17. Tedeschi A, Omura T, Costigan M. CNS repair and axon regeneration: Using genetic variation to determine mechanisms. Exp Neurol. 2017 Jan; 287(Pt 3):409-422. PMID: 27163547.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  18. Omura T, Omura K, Tedeschi A, Riva P, Painter MW, Rojas L, Martin J, Lisi V, Huebner EA, Latremoliere A, Yin Y, Barrett LB, Singh B, Lee S, Crisman T, Gao F, Li S, Kapur K, Geschwind DH, Kosik KS, Coppola G, He Z, Carmichael ST, Benowitz LI, Costigan M, Woolf CJ. Robust Axonal Regeneration Occurs in the Injured CAST/Ei Mouse CNS. Neuron. 2016 May 04; 90(3):662. PMID: 27151643.
    Citations: 2     Fields:    
  19. Chandran V, Coppola G, Nawabi H, Omura T, Versano R, Huebner EA, Zhang A, Costigan M, Yekkirala A, Barrett L, Blesch A, Michaelevski I, Davis-Turak J, Gao F, Langfelder P, Horvath S, He Z, Benowitz L, Fainzilber M, Tuszynski M, Woolf CJ, Geschwind DH. A Systems-Level Analysis of the Peripheral Nerve Intrinsic Axonal Growth Program. Neuron. 2016 Mar 02; 89(5):956-70. PMID: 26898779.
    Citations: 68     Fields:    Translation:AnimalsCells
  20. Dulin JN, Antunes-Martins A, Chandran V, Costigan M, Lerch JK, Willis DE, Tuszynski MH. Transcriptomic Approaches to Neural Repair. J Neurosci. 2015 Oct 14; 35(41):13860-7. PMID: 26468186.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  21. Latremoliere A, Latini A, Andrews N, Cronin SJ, Fujita M, Gorska K, Hovius R, Romero C, Chuaiphichai S, Painter M, Miracca G, Babaniyi O, Remor AP, Duong K, Riva P, Barrett LB, Ferreirós N, Naylor A, Penninger JM, Tegeder I, Zhong J, Blagg J, Channon KM, Johnsson K, Costigan M, Woolf CJ. Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway. Neuron. 2015 Jun 17; 86(6):1393-406. PMID: 26087165.
    Citations: 18     Fields:    Translation:AnimalsCells
  22. Omura T, Omura K, Tedeschi A, Riva P, Painter MW, Rojas L, Martin J, Lisi V, Huebner EA, Latremoliere A, Yin Y, Barrett LB, Singh B, Lee S, Crisman T, Gao F, Li S, Kapur K, Geschwind DH, Kosik KS, Coppola G, He Z, Carmichael ST, Benowitz LI, Costigan M, Woolf CJ. Robust Axonal Regeneration Occurs in the Injured CAST/Ei Mouse CNS. Neuron. 2015 Jun 03; 86(5):1215-27. PMID: 26004914.
    Citations: 25     Fields:    Translation:AnimalsCells
  23. Vicuña L, Strochlic DE, Latremoliere A, Bali KK, Simonetti M, Husainie D, Prokosch S, Riva P, Griffin RS, Njoo C, Gehrig S, Mall MA, Arnold B, Devor M, Woolf CJ, Liberles SD, Costigan M, Kuner R. The serine protease inhibitor SerpinA3N attenuates neuropathic pain by inhibiting T cell-derived leukocyte elastase. Nat Med. 2015 May; 21(5):518-23. PMID: 25915831.
    Citations: 45     Fields:    Translation:AnimalsCells
  24. Yang F, Fu H, Lu YF, Wang XL, Yang Y, Yang F, Yu YQ, Sun W, Wang JS, Costigan M, Chen J. Post-stroke pain hypersensitivity induced by experimental thalamic hemorrhage in rats is region-specific and demonstrates limited efficacy of gabapentin. Neurosci Bull. 2014 Dec; 30(6):887-902. PMID: 25370442.
    Citations: 7     Fields:    Translation:Animals
  25. Young EE, Costigan M, Herbert TA, Lariviere WR. Heritability of nociception IV: neuropathic pain assays are genetically distinct across methods of peripheral nerve injury. Pain. 2014 May; 155(5):868-80. PMID: 24071598.
    Citations: 5     Fields:    Translation:Animals
  26. Xie F, Fu H, Hou JF, Jiao K, Costigan M, Chen J. High energy diets-induced metabolic and prediabetic painful polyneuropathy in rats. PLoS One. 2013; 8(2):e57427. PMID: 23451227.
    Citations: 4     Fields:    Translation:AnimalsCells
  27. Simonetti M, Hagenston AM, Vardeh D, Freitag HE, Mauceri D, Lu J, Satagopam VP, Schneider R, Costigan M, Bading H, Kuner R. Nuclear calcium signaling in spinal neurons drives a genomic program required for persistent inflammatory pain. Neuron. 2013 Jan 09; 77(1):43-57. PMID: 23312515.
    Citations: 39     Fields:    Translation:AnimalsCells
  28. Neely GG, Rao S, Costigan M, Mair N, Racz I, Milinkeviciute G, Meixner A, Nayanala S, Griffin RS, Belfer I, Dai F, Smith S, Diatchenko L, Marengo S, Haubner BJ, Novatchkova M, Gibson D, Maixner W, Pospisilik JA, Hirsch E, Whishaw IQ, Zimmer A, Gupta V, Sasaki J, Kanaho Y, Sasaki T, Kress M, Woolf CJ, Penninger JM. Construction of a global pain systems network highlights phospholipid signaling as a regulator of heat nociception. PLoS Genet. 2012; 8(12):e1003071. PMID: 23236288.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  29. Sorge RE, Trang T, Dorfman R, Smith SB, Beggs S, Ritchie J, Austin JS, Zaykin DV, Vander Meulen H, Costigan M, Herbert TA, Yarkoni-Abitbul M, Tichauer D, Livneh J, Gershon E, Zheng M, Tan K, John SL, Slade GD, Jordan J, Woolf CJ, Peltz G, Maixner W, Diatchenko L, Seltzer Z, Salter MW, Mogil JS. Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity. Nat Med. 2012 Mar 25; 18(4):595-9. PMID: 22447075.
    Citations: 108     Fields:    Translation:HumansAnimalsCells
  30. Costigan M. Pain's peptide signature. Pain. 2012 Mar; 153(3):509-10. PMID: 22264678.
    Citations: 4     Fields:    Translation:Humans
  31. Costigan M, Latremoliere A, Woolf CJ. Analgesia by inhibiting tetrahydrobiopterin synthesis. Curr Opin Pharmacol. 2012 Feb; 12(1):92-9. PMID: 22178186.
    Citations: 12     Fields:    Translation:Humans
  32. Ma CH, Brenner GJ, Omura T, Samad OA, Costigan M, Inquimbert P, Niederkofler V, Salie R, Sun CC, Lin HY, Arber S, Coppola G, Woolf CJ, Samad TA. The BMP coreceptor RGMb promotes while the endogenous BMP antagonist noggin reduces neurite outgrowth and peripheral nerve regeneration by modulating BMP signaling. J Neurosci. 2011 Dec 14; 31(50):18391-400. PMID: 22171041.
    Citations: 25     Fields:    Translation:AnimalsCells
  33. Ma CH, Omura T, Cobos EJ, Latrémolière A, Ghasemlou N, Brenner GJ, van Veen E, Barrett L, Sawada T, Gao F, Coppola G, Gertler F, Costigan M, Geschwind D, Woolf CJ. Accelerating axonal growth promotes motor recovery after peripheral nerve injury in mice. J Clin Invest. 2011 Nov; 121(11):4332-47. PMID: 21965333.
    Citations: 63     Fields:    Translation:HumansAnimalsCells
  34. Latremoliere A, Costigan M. GCH1, BH4 and pain. Curr Pharm Biotechnol. 2011 Oct; 12(10):1728-41. PMID: 21466440.
    Citations: 12     Fields:    Translation:HumansAnimals
  35. Neely GG, Keene AC, Duchek P, Chang EC, Wang QP, Aksoy YA, Rosenzweig M, Costigan M, Woolf CJ, Garrity PA, Penninger JM. TrpA1 regulates thermal nociception in Drosophila. PLoS One. 2011; 6(8):e24343. PMID: 21909389.
    Citations: 52     Fields:    Translation:AnimalsCells
  36. Neely GG, Hess A, Costigan M, Keene AC, Goulas S, Langeslag M, Griffin RS, Belfer I, Dai F, Smith SB, Diatchenko L, Gupta V, Xia CP, Amann S, Kreitz S, Heindl-Erdmann C, Wolz S, Ly CV, Arora S, Sarangi R, Dan D, Novatchkova M, Rosenzweig M, Gibson DG, Truong D, Schramek D, Zoranovic T, Cronin SJ, Angjeli B, Brune K, Dietzl G, Maixner W, Meixner A, Thomas W, Pospisilik JA, Alenius M, Kress M, Subramaniam S, Garrity PA, Bellen HJ, Woolf CJ, Penninger JM. A genome-wide Drosophila screen for heat nociception identifies a2d3 as an evolutionarily conserved pain gene. Cell. 2010 Nov 12; 143(4):628-38. PMID: 21074052.
    Citations: 103     Fields:    Translation:HumansAnimals
  37. del Camino D, Murphy S, Heiry M, Barrett LB, Earley TJ, Cook CA, Petrus MJ, Zhao M, D'Amours M, Deering N, Brenner GJ, Costigan M, Hayward NJ, Chong JA, Fanger CM, Woolf CJ, Patapoutian A, Moran MM. TRPA1 contributes to cold hypersensitivity. J Neurosci. 2010 Nov 10; 30(45):15165-74. PMID: 21068322.
    Citations: 105     Fields:    Translation:AnimalsCells
  38. Costigan M, Belfer I, Griffin RS, Dai F, Barrett LB, Coppola G, Wu T, Kiselycznyk C, Poddar M, Lu Y, Diatchenko L, Smith S, Cobos EJ, Zaykin D, Allchorne A, Gershon E, Livneh J, Shen PH, Nikolajsen L, Karppinen J, Männikkö M, Kelempisioti A, Goldman D, Maixner W, Geschwind DH, Max MB, Seltzer Z, Woolf CJ. Multiple chronic pain states are associated with a common amino acid-changing allele in KCNS1. Brain. 2010 Sep; 133(9):2519-27. PMID: 20724292.
    Citations: 82     Fields:    Translation:HumansAnimals
  39. Bishay P, Schmidt H, Marian C, Häussler A, Wijnvoord N, Ziebell S, Metzner J, Koch M, Myrczek T, Bechmann I, Kuner R, Costigan M, Dehghani F, Geisslinger G, Tegeder I. R-flurbiprofen reduces neuropathic pain in rodents by restoring endogenous cannabinoids. PLoS One. 2010 May 13; 5(5):e10628. PMID: 20498712.
    Citations: 31     Fields:    Translation:AnimalsCells
  40. Costigan M, Moss A, Latremoliere A, Johnston C, Verma-Gandhu M, Herbert TA, Barrett L, Brenner GJ, Vardeh D, Woolf CJ, Fitzgerald M. T-cell infiltration and signaling in the adult dorsal spinal cord is a major contributor to neuropathic pain-like hypersensitivity. J Neurosci. 2009 Nov 18; 29(46):14415-22. PMID: 19923276.
    Citations: 124     Fields:    Translation:AnimalsCells
  41. Vardeh D, Wang D, Costigan M, Lazarus M, Saper CB, Woolf CJ, Fitzgerald GA, Samad TA. COX2 in CNS neural cells mediates mechanical inflammatory pain hypersensitivity in mice. J Clin Invest. 2009 Feb; 119(2):287-94. PMID: 19127021.
    Citations: 37     Fields:    Translation:AnimalsCells
  42. Costigan M, Scholz J, Woolf CJ. Neuropathic pain: a maladaptive response of the nervous system to damage. Annu Rev Neurosci. 2009; 32:1-32. PMID: 19400724.
    Citations: 433     Fields:    Translation:HumansAnimalsCells
  43. Moss A, Ingram R, Koch S, Theodorou A, Low L, Baccei M, Hathway GJ, Costigan M, Salton SR, Fitzgerald M. Origins, actions and dynamic expression patterns of the neuropeptide VGF in rat peripheral and central sensory neurones following peripheral nerve injury. Mol Pain. 2008 Dec 10; 4:62. PMID: 19077191.
    Citations: 20     Fields:    Translation:AnimalsCells
  44. Antoniades C, Shirodaria C, Van Assche T, Cunnington C, Tegeder I, Lötsch J, Guzik TJ, Leeson P, Diesch J, Tousoulis D, Stefanadis C, Costigan M, Woolf CJ, Alp NJ, Channon KM. GCH1 haplotype determines vascular and plasma biopterin availability in coronary artery disease effects on vascular superoxide production and endothelial function. J Am Coll Cardiol. 2008 Jul 08; 52(2):158-65. PMID: 18598896.
    Citations: 27     Fields:    Translation:Humans
  45. Mills C, Makwana M, Wallace A, Benn S, Schmidt H, Tegeder I, Costigan M, Brown RH, Raivich G, Woolf CJ. Ro5-4864 promotes neonatal motor neuron survival and nerve regeneration in adult rats. Eur J Neurosci. 2008 Feb; 27(4):937-46. PMID: 18333964.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  46. Griffin RS, Costigan M, Brenner GJ, Ma CH, Scholz J, Moss A, Allchorne AJ, Stahl GL, Woolf CJ. Complement induction in spinal cord microglia results in anaphylatoxin C5a-mediated pain hypersensitivity. J Neurosci. 2007 Aug 08; 27(32):8699-708. PMID: 17687047.
    Citations: 87     Fields:    Translation:AnimalsCells
  47. Mills CD, Allchorne AJ, Griffin RS, Woolf CJ, Costigan M. GDNF selectively promotes regeneration of injury-primed sensory neurons in the lesioned spinal cord. Mol Cell Neurosci. 2007 Oct; 36(2):185-94. PMID: 17702601.
    Citations: 19     Fields:    Translation:AnimalsCells
  48. Lötsch J, Belfer I, Kirchhof A, Mishra BK, Max MB, Doehring A, Costigan M, Woolf CJ, Geisslinger G, Tegeder I. Reliable screening for a pain-protective haplotype in the GTP cyclohydrolase 1 gene (GCH1) through the use of 3 or fewer single nucleotide polymorphisms. Clin Chem. 2007 Jun; 53(6):1010-5. PMID: 17363416.
    Citations: 15     Fields:    Translation:Humans
  49. Amaya F, Wang H, Costigan M, Allchorne AJ, Hatcher JP, Egerton J, Stean T, Morisset V, Grose D, Gunthorpe MJ, Chessell IP, Tate S, Green PJ, Woolf CJ. The voltage-gated sodium channel Na(v)1.9 is an effector of peripheral inflammatory pain hypersensitivity. J Neurosci. 2006 Dec 13; 26(50):12852-60. PMID: 17167076.
    Citations: 101     Fields:    Translation:AnimalsCells
  50. Moss A, Beggs S, Vega-Avelaira D, Costigan M, Hathway GJ, Salter MW, Fitzgerald M. Spinal microglia and neuropathic pain in young rats. Pain. 2007 Apr; 128(3):215-24. PMID: 17110040.
    Citations: 42     Fields:    Translation:AnimalsCells
  51. Tegeder I, Costigan M, Griffin RS, Abele A, Belfer I, Schmidt H, Ehnert C, Nejim J, Marian C, Scholz J, Wu T, Allchorne A, Diatchenko L, Binshtok AM, Goldman D, Adolph J, Sama S, Atlas SJ, Carlezon WA, Parsegian A, Lötsch J, Fillingim RB, Maixner W, Geisslinger G, Max MB, Woolf CJ. GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence. Nat Med. 2006 Nov; 12(11):1269-77. PMID: 17057711.
    Citations: 141     Fields:    Translation:HumansAnimals
  52. Costigan M, Samad TA, Allchorne A, Lanoue C, Tate S, Woolf CJ. High basal expression and injury-induced down regulation of two regulator of G-protein signaling transcripts, RGS3 and RGS4 in primary sensory neurons. Mol Cell Neurosci. 2003 Sep; 24(1):106-16. PMID: 14550772.
    Citations: 9     Fields:    Translation:AnimalsCells
  53. Griffin RS, Mills CD, Costigan M, Woolf CJ. Exploiting microarrays to reveal differential gene expression in the nervous system. Genome Biol. 2003; 4(2):105. PMID: 12620110.
    Citations: 8     Fields:    Translation:HumansAnimals
  54. Costigan M, Befort K, Karchewski L, Griffin RS, D'Urso D, Allchorne A, Sitarski J, Mannion JW, Pratt RE, Woolf CJ. Replicate high-density rat genome oligonucleotide microarrays reveal hundreds of regulated genes in the dorsal root ganglion after peripheral nerve injury. BMC Neurosci. 2002 Oct 25; 3:16. PMID: 12401135.
    Citations: 203     Fields:    Translation:AnimalsCells
  55. Costigan M, Woolf CJ. No DREAM, No pain. Closing the spinal gate. Cell. 2002 Feb 08; 108(3):297-300. PMID: 11853663.
    Citations: 19     Fields:    Translation:HumansAnimals
  56. Benn SC, Costigan M, Tate S, Fitzgerald M, Woolf CJ. Developmental expression of the TTX-resistant voltage-gated sodium channels Nav1.8 (SNS) and Nav1.9 (SNS2) in primary sensory neurons. J Neurosci. 2001 Aug 15; 21(16):6077-85. PMID: 11487631.
    Citations: 40     Fields:    Translation:AnimalsCells
  57. Befort K, Costigan M, Woolf CJ. Differential gene expression--how to find new analgesic targets. Curr Opin Investig Drugs. 2001 Mar; 2(3):396-8. PMID: 11575712.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  58. Delany NS, Hurle M, Facer P, Alnadaf T, Plumpton C, Kinghorn I, See CG, Costigan M, Anand P, Woolf CJ, Crowther D, Sanseau P, Tate SN. Identification and characterization of a novel human vanilloid receptor-like protein, VRL-2. Physiol Genomics. 2001 Jan 19; 4(3):165-74. PMID: 11160995.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  59. Costigan M, Woolf CJ. Pain: molecular mechanisms. J Pain. 2000 Sep; 1(3 Suppl):35-44. PMID: 14622841.
    Citations: 22     Fields:    
  60. Amaya F, Decosterd I, Samad TA, Plumpton C, Tate S, Mannion RJ, Costigan M, Woolf CJ. Diversity of expression of the sensory neuron-specific TTX-resistant voltage-gated sodium ion channels SNS and SNS2. Mol Cell Neurosci. 2000 Apr; 15(4):331-42. PMID: 10845770.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  61. Lewis SE, Mannion RJ, White FA, Coggeshall RE, Beggs S, Costigan M, Martin JL, Dillmann WH, Woolf CJ. A role for HSP27 in sensory neuron survival. J Neurosci. 1999 Oct 15; 19(20):8945-53. PMID: 10516313.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  62. Mannion RJ, Costigan M, Decosterd I, Amaya F, Ma QP, Holstege JC, Ji RR, Acheson A, Lindsay RM, Wilkinson GA, Woolf CJ. Neurotrophins: peripherally and centrally acting modulators of tactile stimulus-induced inflammatory pain hypersensitivity. Proc Natl Acad Sci U S A. 1999 Aug 03; 96(16):9385-90. PMID: 10430952.
    Citations: 97     Fields:    Translation:AnimalsCells
  63. Woolf CJ, Costigan M. Transcriptional and posttranslational plasticity and the generation of inflammatory pain. Proc Natl Acad Sci U S A. 1999 Jul 06; 96(14):7723-30. PMID: 10393888.
    Citations: 111     Fields:    Translation:HumansAnimalsCells
  64. Tate S, Benn S, Hick C, Trezise D, John V, Mannion RJ, Costigan M, Plumpton C, Grose D, Gladwell Z, Kendall G, Dale K, Bountra C, Woolf CJ. Two sodium channels contribute to the TTX-R sodium current in primary sensory neurons. Nat Neurosci. 1998 Dec; 1(8):653-5. PMID: 10196578.
    Citations: 51     Fields:    Translation:AnimalsCells
  65. Costigan M, Mannion RJ, Kendall G, Lewis SE, Campagna JA, Coggeshall RE, Meridith-Middleton J, Tate S, Woolf CJ. Heat shock protein 27: developmental regulation and expression after peripheral nerve injury. J Neurosci. 1998 Aug 01; 18(15):5891-900. PMID: 9671676.
    Citations: 39     Fields:    Translation:AnimalsCells
  66. Costigan M, Chambers DA, Boot-Handford RP. Collagen turnover in renal disease. Exp Nephrol. 1995 Mar-Apr; 3(2):114-21. PMID: 7773630.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.