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Elena Levantini, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Levantini E, Maroni G, Del Re M, Tenen DG. EGFR signaling pathway as therapeutic target in human cancers. Semin Cancer Biol. 2022 10; 85:253-275. PMID: 35427766.
    Citations: 1     Fields:    
  2. Levantini E. Is miR therapeutic targeting still a miRage? Front Biosci (Landmark Ed). 2021 10 30; 26(10):680-692. PMID: 34719197.
    Citations:    Fields:    Translation:Humans
  3. Trinh BQ, Ummarino S, Zhang Y, Ebralidze AK, Bassal MA, Nguyen TM, Heller G, Coffey R, Tenen DE, van der Kouwe E, Fabiani E, Gurnari C, Wu CS, Angarica VE, Yang H, Chen S, Zhang H, Thurm AR, Marchi F, Levantini E, Staber PB, Zhang P, Voso MT, Pandolfi PP, Kobayashi SS, Chai L, Di Ruscio A, Tenen DG. Myeloid lncRNA LOUP mediates opposing regulatory effects of RUNX1 and RUNX1-ETO in t(8;21) AML. Blood. 2021 10 14; 138(15):1331-1344. PMID: 33971010; PMCID: PMC8525335.
    Citations: 4     Fields:    Translation:HumansCells
  4. Maroni G, Bassal MA, Krishnan I, Fhu CW, Savova V, Zilionis R, Maymi VA, Pandell N, Csizmadia E, Zhang J, Storti B, Castaño J, Panella R, Li J, Gustafson CE, Fox S, Levy RD, Meyerovitz CV, Tramontozzi PJ, Vermilya K, De Rienzo A, Crucitta S, Bassères DS, Weetall M, Branstrom A, Giorgetti A, Ciampi R, Del Re M, Danesi R, Bizzarri R, Yang H, Kocher O, Klein AM, Welner RS, Bueno R, Magli MC, Clohessy JG, Ali A, Tenen DG, Levantini E. Identification of a targetable KRAS-mutant epithelial population in non-small cell lung cancer. Commun Biol. 2021 04 14; 4(1):370. PMID: 33854168; PMCID: PMC8046784.
    Citations: 2     Translation:HumansAnimalsCells
  5. Rodrigues FS, Miranda VS, Carneiro-Lobo TC, Scalabrini LC, Kruspig B, Levantini E, Murphy DJ, Bassères DS. IKKß Kinase Promotes Stemness, Migration, and Invasion in KRAS-Driven Lung Adenocarcinoma Cells. Int J Mol Sci. 2020 Aug 13; 21(16). PMID: 32823550; PMCID: PMC7460870.
    Citations: 1     Fields:    Translation:HumansCells
  6. Gomes-Filho SM, Dos Santos EO, Bertoldi ERM, Scalabrini LC, Heidrich V, Dazzani B, Levantini E, Reis EM, Bassères DS. Aurora A kinase and its activator TPX2 are potential therapeutic targets in KRAS-induced pancreatic cancer. Cell Oncol (Dordr). 2020 Jun; 43(3):445-460. PMID: 32193808.
    Citations: 8     Fields:    Translation:HumansCells
  7. Chin TM, Boopathy GTK, Man EPS, Clohessy JG, Csizmadia E, Quinlan MP, Putti T, Wan SC, Xie C, Ali A, Wai FC, Ong YS, Goh BC, Settleman J, Hong W, Levantini E, Tenen DG. Targeting microtubules sensitizes drug resistant lung cancer cells to lysosomal pathway inhibitors. Theranostics. 2020; 10(6):2727-2743. PMID: 32194831.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  8. Ali A, Levantini E, Fhu CW, Teo JT, Clohessy JG, Goggi JL, Wu CS, Chen L, Chin TM, Tenen DG. CAV1 - GLUT3 signaling is important for cellular energy and can be targeted by Atorvastatin in Non-Small Cell Lung Cancer. Theranostics. 2019; 9(21):6157-6174. PMID: 31534543.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  9. Maroni G, Panetta D, Luongo R, Krishnan I, La Rosa F, Campani D, Salvadori P, Iozzo P, Blasi F, Penkov D, Levantini E, Magli MC. The Role of Prep1 in the Regulation of Mesenchymal Stromal Cells. Int J Mol Sci. 2019 Jul 25; 20(15). PMID: 31349607; PMCID: PMC6696203.
    Citations: 2     Fields:    Translation:AnimalsCells
  10. Storti B, Civita S, Faraci P, Maroni G, Krishnan I, Levantini E, Bizzarri R. Fluorescence imaging of biochemical relationship between ubiquitinated histone 2A and Polycomb complex protein BMI1. Biophys Chem. 2019 10; 253:106225. PMID: 31323431.
    Citations: 6     Fields:    Translation:HumansCells
  11. Zilionis R, Engblom C, Pfirschke C, Savova V, Zemmour D, Saatcioglu HD, Krishnan I, Maroni G, Meyerovitz CV, Kerwin CM, Choi S, Richards WG, De Rienzo A, Tenen DG, Bueno R, Levantini E, Pittet MJ, Klein AM. Single-Cell Transcriptomics of Human and Mouse Lung Cancers Reveals Conserved Myeloid Populations across Individuals and Species. Immunity. 2019 05 21; 50(5):1317-1334.e10. PMID: 30979687.
    Citations: 314     Fields:    Translation:HumansAnimalsCells
  12. Carneiro-Lobo TC, Scalabrini LC, Magalhães LDS, Cardeal LB, Rodrigues FS, Dos Santos EO, Baldwin AS, Levantini E, Giordano RJ, Bassères DS. IKKß targeting reduces KRAS-induced lung cancer angiogenesis in vitro and in vivo: A potential anti-angiogenic therapeutic target. Lung Cancer. 2019 04; 130:169-178. PMID: 30885340; PMCID: PMC6873699.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  13. Ali A, Levantini E, Teo JT, Goggi J, Clohessy JG, Wu CS, Chen L, Yang H, Krishnan I, Kocher O, Zhang J, Soo RA, Bhakoo K, Chin TM, Tenen DG. Fatty acid synthase mediates EGFR palmitoylation in EGFR mutated non-small cell lung cancer. EMBO Mol Med. 2018 03; 10(3). PMID: 29449326.
    Citations: 42     Fields:    Translation:AnimalsCells
  14. Maroni G, Tkachuk VA, Egorov A, Morelli MJ, Luongo R, Levantini E, Blasi F, Magli MC, Penkov D. Prep1 prevents premature adipogenesis of mesenchymal progenitors. Sci Rep. 2017 Nov 14; 7(1):15573. PMID: 29138456.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  15. Gonzalez D, Luyten A, Bartholdy B, Zhou Q, Kardosova M, Ebralidze A, Swanson KD, Radomska HS, Zhang P, Kobayashi SS, Welner RS, Levantini E, Steidl U, Chong G, Collombet S, Choi MH, Friedman AD, Scott LM, Alberich-Jorda M, Tenen DG. ZNF143 protein is an important regulator of the myeloid transcription factor C/EBPa. J Biol Chem. 2017 11 17; 292(46):18924-18936. PMID: 28900037.
    Citations: 8     Fields:    Translation:HumansCells
  16. Patnaik A, Swanson KD, Csizmadia E, Solanki A, Landon-Brace N, Gehring MP, Helenius K, Olson BM, Pyzer AR, Wang LC, Elemento O, Novak J, Thornley TB, Asara JM, Montaser L, Timmons JJ, Morgan TM, Wang Y, Levantini E, Clohessy JG, Kelly K, Pandolfi PP, Rosenblatt JM, Avigan DE, Ye H, Karp JM, Signoretti S, Balk SP, Cantley LC. Cabozantinib Eradicates Advanced Murine Prostate Cancer by Activating Antitumor Innate Immunity. Cancer Discov. 2017 07; 7(7):750-765. PMID: 28274958; PMCID: PMC5501767.
    Citations: 59     Fields:    Translation:HumansAnimalsCells
  17. Bonifer C, Levantini E, Kouskoff V, Lacaud G. Runx1 Structure and Function in Blood Cell Development. Adv Exp Med Biol. 2017; 962:65-81. PMID: 28299651.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  18. Yong KJ, Basseres DS, Welner RS, Zhang WC, Yang H, Yan B, Alberich-Jorda M, Zhang J, de Figueiredo-Pontes LL, Battelli C, Hetherington CJ, Ye M, Zhang H, Maroni G, O'Brien K, Magli MC, Borczuk AC, Varticovski L, Kocher O, Zhang P, Moon YC, Sydorenko N, Cao L, Davis TW, Thakkar BM, Soo RA, Iwama A, Lim B, Halmos B, Neuberg D, Tenen DG, Levantini E. Targeted BMI1 inhibition impairs tumor growth in lung adenocarcinomas with low CEBPa expression. Sci Transl Med. 2016 08 03; 8(350):350ra104. PMID: 27488898.
    Citations: 24     Fields:    Translation:HumansAnimals
  19. Bararia D, Kwok HS, Welner RS, Numata A, Sárosi MB, Yang H, Wee S, Tschuri S, Ray D, Weigert O, Levantini E, Ebralidze AK, Gunaratne J, Tenen DG. Acetylation of C/EBPa inhibits its granulopoietic function. Nat Commun. 2016 Mar 23; 7:10968. PMID: 27005833.
    Citations: 16     Fields:    Translation:HumansCells
  20. Dos Santos EO, Carneiro-Lobo TC, Aoki MN, Levantini E, Bassères DS. Aurora kinase targeting in lung cancer reduces KRAS-induced transformation. Mol Cancer. 2016 Feb 03; 15:12. PMID: 26842935; PMCID: PMC4739397.
    Citations: 19     Fields:    Translation:AnimalsCells
  21. Ye M, Zhang H, Yang H, Koche R, Staber PB, Cusan M, Levantini E, Welner RS, Bach CS, Zhang J, Krivtsov AV, Armstrong SA, Tenen DG. Hematopoietic Differentiation Is Required for Initiation of Acute Myeloid Leukemia. Cell Stem Cell. 2015 Nov 05; 17(5):611-23. PMID: 26412561.
    Citations: 57     Fields:    Translation:AnimalsCells
  22. Amabile G, Di Ruscio A, Müller F, Welner RS, Yang H, Ebralidze AK, Zhang H, Levantini E, Qi L, Martinelli G, Brummelkamp T, Le Beau MM, Figueroa ME, Bock C, Tenen DG. Dissecting the role of aberrant DNA methylation in human leukaemia. Nat Commun. 2015 May 22; 6:7091. PMID: 25997600.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  23. Welner RS, Amabile G, Bararia D, Czibere A, Yang H, Zhang H, Pontes LL, Ye M, Levantini E, Di Ruscio A, Martinelli G, Tenen DG. Treatment of chronic myelogenous leukemia by blocking cytokine alterations found in normal stem and progenitor cells. Cancer Cell. 2015 May 11; 27(5):671-81. PMID: 25965572.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  24. Cai Y, Hirata A, Nakayama S, VanderLaan PA, Levantini E, Yamamoto M, Hirai H, Wong KK, Costa DB, Watanabe H, Kobayashi SS. CCAAT/enhancer binding protein ß is dispensable for development of lung adenocarcinoma. PLoS One. 2015; 10(3):e0120647. PMID: 25767874.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  25. Staber PB, Zhang P, Ye M, Welner RS, Levantini E, Di Ruscio A, Ebralidze AK, Bach C, Zhang H, Zhang J, Vanura K, Delwel R, Yang H, Huang G, Tenen DG. The Runx-PU.1 pathway preserves normal and AML/ETO9a leukemic stem cells. Blood. 2014 Oct 09; 124(15):2391-9. PMID: 25185713; PMCID: PMC4192750.
    Citations: 20     Fields:    Translation:AnimalsCells
  26. Zhang H, Alberich-Jorda M, Amabile G, Yang H, Staber PB, Di Ruscio A, Diruscio A, Welner RS, Ebralidze A, Zhang J, Levantini E, Lefebvre V, Valk PJ, Delwel R, Hoogenkamp M, Nerlov C, Cammenga J, Saez B, Scadden DT, Bonifer C, Ye M, Tenen DG. Sox4 is a key oncogenic target in C/EBPa mutant acute myeloid leukemia. Cancer Cell. 2013 Nov 11; 24(5):575-88. PMID: 24183681; PMCID: PMC4038627.
    Citations: 66     Fields:    Translation:HumansAnimalsCells
  27. Ye M, Zhang H, Amabile G, Yang H, Staber PB, Zhang P, Levantini E, Alberich-Jordà M, Zhang J, Kawasaki A, Tenen DG. C/EBPa controls acquisition and maintenance of adult haematopoietic stem cell quiescence. Nat Cell Biol. 2013 Apr; 15(4):385-94. PMID: 23502316.
    Citations: 60     Fields:    Translation:AnimalsCells
  28. Peter Y, Sen N, Levantini E, Keller S, Ingenito EP, Ciner A, Sackstein R, Shapiro SD. CD45/CD11b positive subsets of adult lung anchorage-independent cells harness epithelial stem cells in culture. J Tissue Eng Regen Med. 2013 Jul; 7(7):572-83. PMID: 22585451.
    Citations: 2     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  29. Levantini E, Lee S, Radomska HS, Hetherington CJ, Alberich-Jorda M, Amabile G, Zhang P, Gonzalez DA, Zhang J, Basseres DS, Wilson NK, Koschmieder S, Huang G, Zhang DE, Ebralidze AK, Bonifer C, Okuno Y, Gottgens B, Tenen DG. RUNX1 regulates the CD34 gene in haematopoietic stem cells by mediating interactions with a distal regulatory element. EMBO J. 2011 Aug 26; 30(19):4059-70. PMID: 21873977.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  30. Blanchet MR, Bennett JL, Gold MJ, Levantini E, Tenen DG, Girard M, Cormier Y, McNagny KM. CD34 is required for dendritic cell trafficking and pathology in murine hypersensitivity pneumonitis. Am J Respir Crit Care Med. 2011 Sep 15; 184(6):687-98. PMID: 21642249; PMCID: PMC3208601.
    Citations: 18     Fields:    Translation:AnimalsCells
  31. O'Brien KB, Alberich-Jordà M, Yadav N, Kocher O, Diruscio A, Ebralidze A, Levantini E, Sng NJ, Bhasin M, Caron T, Kim D, Steidl U, Huang G, Halmos B, Rodig SJ, Bedford MT, Tenen DG, Kobayashi S. CARM1 is required for proper control of proliferation and differentiation of pulmonary epithelial cells. Development. 2010 Jul; 137(13):2147-56. PMID: 20530543.
    Citations: 33     Fields:    Translation:AnimalsCells
  32. Bassères DS, Ebbs A, Levantini E, Baldwin AS. Requirement of the NF-kappaB subunit p65/RelA for K-Ras-induced lung tumorigenesis. Cancer Res. 2010 May 01; 70(9):3537-46. PMID: 20406971.
    Citations: 109     Fields:    Translation:HumansAnimalsCells
  33. Guibal FC, Alberich-Jorda M, Hirai H, Ebralidze A, Levantini E, Di Ruscio A, Zhang P, Santana-Lemos BA, Neuberg D, Wagers AJ, Rego EM, Tenen DG. Identification of a myeloid committed progenitor as the cancer-initiating cell in acute promyelocytic leukemia. Blood. 2009 Dec 24; 114(27):5415-25. PMID: 19797526; PMCID: PMC2798860.
    Citations: 65     Fields:    Translation:HumansAnimalsCells
  34. Peter Y, Comellas A, Levantini E, Ingenito EP, Shapiro SD. Epidermal growth factor receptor and claudin-2 participate in A549 permeability and remodeling: implications for non-small cell lung cancer tumor colonization. Mol Carcinog. 2009 Jun; 48(6):488-97. PMID: 18942115; PMCID: PMC2763303.
    Citations: 19     Fields:    Translation:HumansCells
  35. Koschmieder S, Halmos B, Levantini E, Tenen DG. Dysregulation of the C/EBPalpha differentiation pathway in human cancer. J Clin Oncol. 2009 Feb 01; 27(4):619-28. PMID: 19075268.
    Citations: 80     Fields:    Translation:HumansCells
  36. Koschmieder S, D'Alò F, Radomska H, Schöneich C, Chang JS, Konopleva M, Kobayashi S, Levantini E, Suh N, Di Ruscio A, Voso MT, Watt JC, Santhanam R, Sargin B, Kantarjian H, Andreeff M, Sporn MB, Perrotti D, Berdel WE, Müller-Tidow C, Serve H, Tenen DG. CDDO induces granulocytic differentiation of myeloid leukemic blasts through translational up-regulation of p42 CCAAT enhancer binding protein alpha. Blood. 2007 Nov 15; 110(10):3695-705. PMID: 17671235; PMCID: PMC2077317.
    Citations: 30     Fields:    Translation:HumansCellsCTClinical Trials
  37. Kubo S, Levantini E, Kobayashi S, Kocher O, Halmos B, Tenen DG, Takahashi M. Three-dimensional magnetic resonance microscopy of pulmonary solitary tumors in transgenic mice. Magn Reson Med. 2006 Sep; 56(3):698-703. PMID: 16902979.
    Citations: 6     Fields:    Translation:Animals
  38. Bassères DS, Levantini E, Ji H, Monti S, Elf S, Dayaram T, Fenyus M, Kocher O, Golub T, Wong KK, Halmos B, Tenen DG. Respiratory failure due to differentiation arrest and expansion of alveolar cells following lung-specific loss of the transcription factor C/EBPalpha in mice. Mol Cell Biol. 2006 Feb; 26(3):1109-23. PMID: 16428462; PMCID: PMC1347037.
    Citations: 35     Fields:    Translation:Animals
  39. Zhang P, Iwasaki-Arai J, Iwasaki H, Fenyus ML, Dayaram T, Owens BM, Shigematsu H, Levantini E, Huettner CS, Lekstrom-Himes JA, Akashi K, Tenen DG. Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBP alpha. Immunity. 2004 Dec; 21(6):853-63. PMID: 15589173.
    Citations: 235     Fields:    Translation:AnimalsCells
  40. Levantini E, Giorgetti A, Cerisoli F, Traggiai E, Guidi A, Martin R, Acampora D, Aplan PD, Keller G, Simeone A, Iscove NN, Hoang T, Magli MC. Unsuspected role of the brain morphogenetic gene Otx1 in hematopoiesis. Proc Natl Acad Sci U S A. 2003 Sep 02; 100(18):10299-303. PMID: 12934017; PMCID: PMC193555.
    Citations: 2     Fields:    Translation:AnimalsCells
  41. Cairns LA, Moroni E, Levantini E, Giorgetti A, Klinger FG, Ronzoni S, Tatangelo L, Tiveron C, De Felici M, Dolci S, Magli MC, Giglioni B, Ottolenghi S. Kit regulatory elements required for expression in developing hematopoietic and germ cell lineages. Blood. 2003 Dec 01; 102(12):3954-62. PMID: 12907433.
    Citations: 39     Fields:    Translation:AnimalsCells
  42. Magli MC, Levantini E, Giorgetti A. Developmental potential of somatic stem cells in mammalian adults. J Hematother Stem Cell Res. 2000 Dec; 9(6):961-9. PMID: 11177611.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  43. Revoltella RP, Laricchia Robbio L, Vikinge T, Pardi E, Levantini E, Beffy P. Human GM-CSF interaction with the alpha-chain of its receptor studied using surface plasmon resonance. Biosens Bioelectron. 1999 Jun 30; 14(6):555-67. PMID: 11459101.
    Citations:    Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.