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Daniel Kahne, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AI153358 (KAHNE, DANIEL) May 21, 2020 - Apr 30, 2025
    NIH/NIAID
    Targeting Membrane Transport Steps in Cell Envelope Assembly
    Role: Principal Investigator
  2. R01AI148752 (WALKER, SUZANNE) Jan 1, 2020 - Dec 31, 2024
    NIH/NIAID
    Discovery and characterization of new bacterial cell wall targets and inhibitors to treat resistant infections
    Role: Co-Principal Investigator
  3. R01AI139011 (LOSICK, RICHARD MARC) May 11, 2018 - Apr 30, 2023
    NIH/NIAID
    Release of Extracellular DNA during Biofilm Formation in Staphylococcus aureus
    Role: Co-Principal Investigator
  4. U19AI109764 (KASPER, DENNIS L.) Mar 1, 2014 - Feb 28, 2019
    NIH/NIAID
    Innovative Platforms for Antimicrobial Therapy and Vaccine Development
    Role: Co-Principal Investigator
  5. R01AI081059 (KAHNE, DANIEL) Dec 15, 2008 - Nov 30, 2014
    NIH/NIAID
    Outer Membrane Biogenesis: New Antibiotic Targets
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Lundstedt E, Kahne D, Ruiz N. Assembly and Maintenance of Lipids at the Bacterial Outer Membrane. Chem Rev. 2020 Sep 21. PMID: 32955879.
    Citations:    
  2. Tomasek D, Rawson S, Lee J, Wzorek JS, Harrison SC, Li Z, Kahne D. Structure of a nascent membrane protein as it folds on the BAM complex. Nature. 2020 07; 583(7816):473-478. PMID: 32528179.
    Citations:    
  3. Rubino FA, Mollo A, Kumar S, Butler EK, Ruiz N, Walker S, Kahne DE. Detection of Transport Intermediates in the Peptidoglycan Flippase MurJ Identifies Residues Essential for Conformational Cycling. J Am Chem Soc. 2020 Mar 25; 142(12):5482-5486. PMID: 32129990.
    Citations:    
  4. Sjodt M, Rohs PDA, Gilman MSA, Erlandson SC, Zheng S, Green AG, Brock KP, Taguchi A, Kahne D, Walker S, Marks DS, Rudner DZ, Bernhardt TG, Kruse AC. Structural coordination of polymerization and crosslinking by a SEDS-bPBP peptidoglycan synthase complex. Nat Microbiol. 2020 06; 5(6):813-820. PMID: 32152588.
    Citations:    
  5. Do T, Schaefer K, Santiago AG, Coe KA, Fernandes PB, Kahne D, Pinho MG, Walker S. Staphylococcus aureus cell growth and division are regulated by an amidase that trims peptides from uncrosslinked peptidoglycan. Nat Microbiol. 2020 02; 5(2):291-303. PMID: 31932712.
    Citations:    
  6. Lee J, Tomasek D, Santos TM, May MD, Meuskens I, Kahne D. Formation of a ß-barrel membrane protein is catalyzed by the interior surface of the assembly machine protein BamA. Elife. 2019 11 14; 8. PMID: 31724945.
    Citations:    
  7. Nagy E, Losick R, Kahne D. Robust Suppression of Lipopolysaccharide Deficiency in Acinetobacter baumannii by Growth in Minimal Medium. J Bacteriol. 2019 11 15; 201(22). PMID: 31451545.
    Citations:    
  8. Taguchi A, Kahne D, Walker S. Chemical tools to characterize peptidoglycan synthases. Curr Opin Chem Biol. 2019 12; 53:44-50. PMID: 31466035.
    Citations:    
  9. Simpson BW, Pahil KS, Owens TW, Lundstedt EA, Davis RM, Kahne D, Ruiz N. Combining Mutations That Inhibit Two Distinct Steps of the ATP Hydrolysis Cycle Restores Wild-Type Function in the Lipopolysaccharide Transporter and Shows that ATP Binding Triggers Transport. mBio. 2019 08 20; 10(4). PMID: 31431556.
    Citations:    
  10. Welsh MA, Schaefer K, Taguchi A, Kahne D, Walker S. Direction of Chain Growth and Substrate Preferences of Shape, Elongation, Division, and Sporulation-Family Peptidoglycan Glycosyltransferases. J Am Chem Soc. 2019 08 21; 141(33):12994-12997. PMID: 31386359.
    Citations:    
  11. Hart EM, O'Connell A, Tang K, Wzorek JS, Grabowicz M, Kahne D, Silhavy TJ. Fine-Tuning of sE Activation Suppresses Multiple Assembly-Defective Mutations in Escherichia coli. J Bacteriol. 2019 06 01; 201(11). PMID: 30858299.
    Citations:    
  12. Owens TW, Taylor RJ, Pahil KS, Bertani BR, Ruiz N, Kruse AC, Kahne D. Structural basis of unidirectional export of lipopolysaccharide to the cell surface. Nature. 2019 03; 567(7749):550-553. PMID: 30894747.
    Citations:    
  13. Taguchi A, Welsh MA, Marmont LS, Lee W, Sjodt M, Kruse AC, Kahne D, Bernhardt TG, Walker S. FtsW is a peptidoglycan polymerase that is functional only in complex with its cognate penicillin-binding protein. Nat Microbiol. 2019 04; 4(4):587-594. PMID: 30692671.
    Citations:    Fields:    
  14. Buss JA, Baidin V, Welsh MA, Flores-Kim J, Cho H, Wood BM, Uehara T, Walker S, Kahne D, Bernhardt TG. Pathway-Directed Screen for Inhibitors of the Bacterial Cell Elongation Machinery. Antimicrob Agents Chemother. 2019 01; 63(1). PMID: 30323039.
    Citations:    Fields:    
  15. Rohs PDA, Buss J, Sim SI, Squyres GR, Srisuknimit V, Smith M, Cho H, Sjodt M, Kruse AC, Garner EC, Walker S, Kahne DE, Bernhardt TG. A central role for PBP2 in the activation of peptidoglycan polymerization by the bacterial cell elongation machinery. PLoS Genet. 2018 10; 14(10):e1007726. PMID: 30335755.
    Citations:    Fields:    
  16. Xie R, Taylor RJ, Kahne D. Outer Membrane Translocon Communicates with Inner Membrane ATPase To Stop Lipopolysaccharide Transport. J Am Chem Soc. 2018 10 10; 140(40):12691-12694. PMID: 30253645.
    Citations:    Fields:    
  17. Bertani BR, Taylor RJ, Nagy E, Kahne D, Ruiz N. A cluster of residues in the lipopolysaccharide exporter that selects substrate variants for transport to the outer membrane. Mol Microbiol. 2018 08; 109(4):541-554. PMID: 29995974.
    Citations:    Fields:    
  18. Mandler MD, Baidin V, Lee J, Pahil KS, Owens TW, Kahne D. Novobiocin Enhances Polymyxin Activity by Stimulating Lipopolysaccharide Transport. J Am Chem Soc. 2018 06 06; 140(22):6749-6753. PMID: 29746111.
    Citations:    Fields:    Translation:Cells
  19. Zhang G, Baidin V, Pahil KS, Moison E, Tomasek D, Ramadoss NS, Chatterjee AK, McNamara CW, Young TS, Schultz PG, Meredith TC, Kahne D. Cell-based screen for discovering lipopolysaccharide biogenesis inhibitors. Proc Natl Acad Sci U S A. 2018 06 26; 115(26):6834-6839. PMID: 29735709.
    Citations: 1     Fields:    Translation:Cells
  20. Sjodt M, Brock K, Dobihal G, Rohs PDA, Green AG, Hopf TA, Meeske AJ, Srisuknimit V, Kahne D, Walker S, Marks DS, Bernhardt TG, Rudner DZ, Kruse AC. Structure of the peptidoglycan polymerase RodA resolved by evolutionary coupling analysis. Nature. 2018 04 05; 556(7699):118-121. PMID: 29590088.
    Citations:    Fields:    Translation:Cells
  21. Rubino FA, Kumar S, Ruiz N, Walker S, Kahne DE. Membrane Potential Is Required for MurJ Function. J Am Chem Soc. 2018 04 04; 140(13):4481-4484. PMID: 29558128.
    Citations:    Fields:    Translation:Cells
  22. Lee W, Do T, Zhang G, Kahne D, Meredith TC, Walker S. Antibiotic Combinations That Enable One-Step, Targeted Mutagenesis of Chromosomal Genes. ACS Infect Dis. 2018 06 08; 4(6):1007-1018. PMID: 29534563.
    Citations:    Fields:    
  23. Lee J, Sutterlin HA, Wzorek JS, Mandler MD, Hagan CL, Grabowicz M, Tomasek D, May MD, Hart EM, Silhavy TJ, Kahne D. Substrate binding to BamD triggers a conformational change in BamA to control membrane insertion. Proc Natl Acad Sci U S A. 2018 03 06; 115(10):2359-2364. PMID: 29463713.
    Citations:    Fields:    Translation:Cells
  24. Sherman DJ, Xie R, Taylor RJ, George AH, Okuda S, Foster PJ, Needleman DJ, Kahne D. Lipopolysaccharide is transported to the cell surface by a membrane-to-membrane protein bridge. Science. 2018 02 16; 359(6377):798-801. PMID: 29449493.
    Citations: 10     Fields:    Translation:Cells
  25. Schaefer K, Owens TW, Kahne D, Walker S. Substrate Preferences Establish the Order of Cell Wall Assembly in Staphylococcus aureus. J Am Chem Soc. 2018 02 21; 140(7):2442-2445. PMID: 29402087.
    Citations:    Fields:    Translation:Cells
  26. Welsh MA, Taguchi A, Schaefer K, Van Tyne D, Lebreton F, Gilmore MS, Kahne D, Walker S. Identification of a Functionally Unique Family of Penicillin-Binding Proteins. J Am Chem Soc. 2017 12 13; 139(49):17727-17730. PMID: 29182854.
    Citations:    
  27. May JM, Owens TW, Mandler MD, Simpson BW, Lazarus MB, Sherman DJ, Davis RM, Okuda S, Massefski W, Ruiz N, Kahne D. The Antibiotic Novobiocin Binds and Activates the ATPase That Powers Lipopolysaccharide Transport. J Am Chem Soc. 2017 12 06; 139(48):17221-17224. PMID: 29135241.
    Citations: 1     Fields:    Translation:Cells
  28. Konovalova A, Kahne DE, Silhavy TJ. Outer Membrane Biogenesis. Annu Rev Microbiol. 2017 09 08; 71:539-556. PMID: 28886680.
    Citations: 2     Fields:    Translation:Cells
  29. Srisuknimit V, Qiao Y, Schaefer K, Kahne D, Walker S. Peptidoglycan Cross-Linking Preferences of Staphylococcus aureus Penicillin-Binding Proteins Have Implications for Treating MRSA Infections. J Am Chem Soc. 2017 07 26; 139(29):9791-9794. PMID: 28691491.
    Citations: 2     Fields:    Translation:Cells
  30. Qiao Y, Srisuknimit V, Rubino F, Schaefer K, Ruiz N, Walker S, Kahne D. Lipid II overproduction allows direct assay of transpeptidase inhibition by ß-lactams. Nat Chem Biol. 2017 Jul; 13(7):793-798. PMID: 28553948.
    Citations: 8     Fields:    Translation:Cells
  31. Moison E, Xie R, Zhang G, Lebar MD, Meredith TC, Kahne D. A Fluorescent Probe Distinguishes between Inhibition of Early and Late Steps of Lipopolysaccharide Biogenesis in Whole Cells. ACS Chem Biol. 2017 04 21; 12(4):928-932. PMID: 28248483.
    Citations: 3     Fields:    Translation:Cells
  32. Wzorek JS, Lee J, Tomasek D, Hagan CL, Kahne DE. Membrane integration of an essential ß-barrel protein prerequires burial of an extracellular loop. Proc Natl Acad Sci U S A. 2017 03 07; 114(10):2598-2603. PMID: 28223520.
    Citations: 6     Fields:    Translation:Cells
  33. Schaefer K, Matano LM, Qiao Y, Kahne D, Walker S. In vitro reconstitution demonstrates the cell wall ligase activity of LCP proteins. Nat Chem Biol. 2017 04; 13(4):396-401. PMID: 28166208.
    Citations: 8     Fields:    Translation:Cells
  34. Simpson BW, Owens TW, Orabella MJ, Davis RM, May JM, Trauger SA, Kahne D, Ruiz N. Identification of Residues in the Lipopolysaccharide ABC Transporter That Coordinate ATPase Activity with Extractor Function. mBio. 2016 10 18; 7(5). PMID: 27795402.
    Citations: 5     Fields:    Translation:Cells
  35. Meeske AJ, Riley EP, Robins WP, Uehara T, Mekalanos JJ, Kahne D, Walker S, Kruse AC, Bernhardt TG, Rudner DZ. SEDS proteins are a widespread family of bacterial cell wall polymerases. Nature. 2016 09 29; 537(7622):634-638. PMID: 27525505.
    Citations: 47     Fields:    Translation:Cells
  36. Lee J, Xue M, Wzorek JS, Wu T, Grabowicz M, Gronenberg LS, Sutterlin HA, Davis RM, Ruiz N, Silhavy TJ, Kahne DE. Characterization of a stalled complex on the ß-barrel assembly machine. Proc Natl Acad Sci U S A. 2016 08 02; 113(31):8717-22. PMID: 27439868.
    Citations: 13     Fields:    Translation:Cells
  37. Markovski M, Bohrhunter JL, Lupoli TJ, Uehara T, Walker S, Kahne DE, Bernhardt TG. Cofactor bypass variants reveal a conformational control mechanism governing cell wall polymerase activity. Proc Natl Acad Sci U S A. 2016 Apr 26; 113(17):4788-93. PMID: 27071112.
    Citations: 7     Fields:    Translation:Cells
  38. Okuda S, Sherman DJ, Silhavy TJ, Ruiz N, Kahne D. Lipopolysaccharide transport and assembly at the outer membrane: the PEZ model. Nat Rev Microbiol. 2016 06; 14(6):337-45. PMID: 27026255.
    Citations: 32     Fields:    Translation:Cells
  39. Lee W, Schaefer K, Qiao Y, Srisuknimit V, Steinmetz H, Müller R, Kahne D, Walker S. The Mechanism of Action of Lysobactin. J Am Chem Soc. 2016 Jan 13; 138(1):100-3. PMID: 26683668.
    Citations: 10     Fields:    Translation:Cells
  40. May JM, Sherman DJ, Simpson BW, Ruiz N, Kahne D. Lipopolysaccharide transport to the cell surface: periplasmic transport and assembly into the outer membrane. Philos Trans R Soc Lond B Biol Sci. 2015 Oct 05; 370(1679). PMID: 26370939.
    Citations: 13     Fields:    Translation:Cells
  41. Simpson BW, May JM, Sherman DJ, Kahne D, Ruiz N. Lipopolysaccharide transport to the cell surface: biosynthesis and extraction from the inner membrane. Philos Trans R Soc Lond B Biol Sci. 2015 Oct 05; 370(1679). PMID: 26370941.
    Citations: 11     Fields:    Translation:Cells
  42. Hagan CL, Wzorek JS, Kahne D. Inhibition of the ß-barrel assembly machine by a peptide that binds BamD. Proc Natl Acad Sci U S A. 2015 Feb 17; 112(7):2011-6. PMID: 25646443.
    Citations: 15     Fields:    Translation:Cells
  43. Grabowicz M, Andres D, Lebar MD, Malojcic G, Kahne D, Silhavy TJ. A mutant Escherichia coli that attaches peptidoglycan to lipopolysaccharide and displays cell wall on its surface. Elife. 2014 Dec 31; 3:e05334. PMID: 25551294.
    Citations: 4     Fields:    Translation:Cells
  44. Qiao Y, Lebar MD, Schirner K, Schaefer K, Tsukamoto H, Kahne D, Walker S. Detection of lipid-linked peptidoglycan precursors by exploiting an unexpected transpeptidase reaction. J Am Chem Soc. 2014 Oct 22; 136(42):14678-81. PMID: 25291014.
    Citations: 22     Fields:    Translation:Cells
  45. Lebar MD, May JM, Meeske AJ, Leiman SA, Lupoli TJ, Tsukamoto H, Losick R, Rudner DZ, Walker S, Kahne D. Reconstitution of peptidoglycan cross-linking leads to improved fluorescent probes of cell wall synthesis. J Am Chem Soc. 2014 Aug 06; 136(31):10874-7. PMID: 25036369.
    Citations: 21     Fields:    Translation:Cells
  46. Sham LT, Butler EK, Lebar MD, Kahne D, Bernhardt TG, Ruiz N. Bacterial cell wall. MurJ is the flippase of lipid-linked precursors for peptidoglycan biogenesis. Science. 2014 Jul 11; 345(6193):220-2. PMID: 25013077.
    Citations: 56     Fields:    Translation:Cells
  47. Malojcic G, Andres D, Grabowicz M, George AH, Ruiz N, Silhavy TJ, Kahne D. LptE binds to and alters the physical state of LPS to catalyze its assembly at the cell surface. Proc Natl Acad Sci U S A. 2014 Jul 01; 111(26):9467-72. PMID: 24938785.
    Citations: 18     Fields:    Translation:Cells
  48. Sherman DJ, Lazarus MB, Murphy L, Liu C, Walker S, Ruiz N, Kahne D. Decoupling catalytic activity from biological function of the ATPase that powers lipopolysaccharide transport. Proc Natl Acad Sci U S A. 2014 Apr 01; 111(13):4982-7. PMID: 24639492.
    Citations: 22     Fields:    Translation:Cells
  49. Lupoli TJ, Lebar MD, Markovski M, Bernhardt T, Kahne D, Walker S. Lipoprotein activators stimulate Escherichia coli penicillin-binding proteins by different mechanisms. J Am Chem Soc. 2014 Jan 08; 136(1):52-5. PMID: 24341982.
    Citations: 19     Fields:    Translation:Cells
  50. Rebets Y, Lupoli T, Qiao Y, Schirner K, Villet R, Hooper D, Kahne D, Walker S. Moenomycin resistance mutations in Staphylococcus aureus reduce peptidoglycan chain length and cause aberrant cell division. ACS Chem Biol. 2014 Feb 21; 9(2):459-67. PMID: 24255971.
    Citations: 9     Fields:    Translation:HumansCells
  51. Zhang G, Meredith TC, Kahne D. On the essentiality of lipopolysaccharide to Gram-negative bacteria. Curr Opin Microbiol. 2013 Dec; 16(6):779-85. PMID: 24148302.
    Citations: 29     Fields:    Translation:Cells
  52. Leiman SA, May JM, Lebar MD, Kahne D, Kolter R, Losick R. D-amino acids indirectly inhibit biofilm formation in Bacillus subtilis by interfering with protein synthesis. J Bacteriol. 2013 Dec; 195(23):5391-5. PMID: 24097941.
    Citations: 29     Fields:    Translation:Cells
  53. Hagan CL, Westwood DB, Kahne D. bam Lipoproteins Assemble BamA in vitro. Biochemistry. 2013 Sep 03; 52(35):6108-13. PMID: 23919461.
    Citations: 18     Fields:    Translation:Cells
  54. Sherman DJ, Okuda S, Denny WA, Kahne D. Validation of inhibitors of an ABC transporter required to transport lipopolysaccharide to the cell surface in Escherichia coli. Bioorg Med Chem. 2013 Aug 15; 21(16):4846-51. PMID: 23665139.
    Citations: 10     Fields:    Translation:Cells
  55. Lebar MD, Lupoli TJ, Tsukamoto H, May JM, Walker S, Kahne D. Forming cross-linked peptidoglycan from synthetic gram-negative Lipid II. J Am Chem Soc. 2013 Mar 27; 135(12):4632-5. PMID: 23480167.
    Citations: 19     Fields:    Translation:Cells
  56. Gampe CM, Tsukamoto H, Doud EH, Walker S, Kahne D. Tuning the moenomycin pharmacophore to enable discovery of bacterial cell wall synthesis inhibitors. J Am Chem Soc. 2013 Mar 13; 135(10):3776-9. PMID: 23448584.
    Citations: 5     Fields:    Translation:Cells
  57. Villa R, Martorana AM, Okuda S, Gourlay LJ, Nardini M, Sperandeo P, Dehò G, Bolognesi M, Kahne D, Polissi A. The Escherichia coli Lpt transenvelope protein complex for lipopolysaccharide export is assembled via conserved structurally homologous domains. J Bacteriol. 2013 Mar; 195(5):1100-8. PMID: 23292770.
    Citations: 23     Fields:    Translation:Cells
  58. Okuda S, Freinkman E, Kahne D. Cytoplasmic ATP hydrolysis powers transport of lipopolysaccharide across the periplasm in E. coli. Science. 2012 Nov 30; 338(6111):1214-7. PMID: 23138981.
    Citations: 50     Fields:    Translation:Cells
  59. Yao Z, Kahne D, Kishony R. Distinct single-cell morphological dynamics under beta-lactam antibiotics. Mol Cell. 2012 Dec 14; 48(5):705-12. PMID: 23103254.
    Citations: 37     Fields:    Translation:Cells
  60. Chng SS, Xue M, Garner RA, Kadokura H, Boyd D, Beckwith J, Kahne D. Disulfide rearrangement triggered by translocon assembly controls lipopolysaccharide export. Science. 2012 Sep 28; 337(6102):1665-8. PMID: 22936569.
    Citations: 29     Fields:    Translation:Cells
  61. Yao Z, Davis RM, Kishony R, Kahne D, Ruiz N. Regulation of cell size in response to nutrient availability by fatty acid biosynthesis in Escherichia coli. Proc Natl Acad Sci U S A. 2012 Sep 18; 109(38):E2561-8. PMID: 22908292.
    Citations: 47     Fields:    Translation:Cells
  62. Freinkman E, Okuda S, Ruiz N, Kahne D. Regulated assembly of the transenvelope protein complex required for lipopolysaccharide export. Biochemistry. 2012 Jun 19; 51(24):4800-6. PMID: 22668317.
    Citations: 40     Fields:    Translation:Cells
  63. Ricci DP, Hagan CL, Kahne D, Silhavy TJ. Activation of the Escherichia coli ß-barrel assembly machine (Bam) is required for essential components to interact properly with substrate. Proc Natl Acad Sci U S A. 2012 Feb 28; 109(9):3487-91. PMID: 22331884.
    Citations: 25     Fields:    Translation:Cells
  64. Gampe CM, Tsukamoto H, Wang TS, Walker S, Kahne D. Modular synthesis of diphospholipid oligosaccharide fragments of the bacterial cell wall and their use to study the mechanism of moenomycin and other antibiotics. Tetrahedron. 2011 Dec 23; 67(51):9771-9778. PMID: 22505780.
    Citations: 8     Fields:    
  65. Oman TJ, Lupoli TJ, Wang TS, Kahne D, Walker S, van der Donk WA. Haloduracin a binds the peptidoglycan precursor lipid II with 2:1 stoichiometry. J Am Chem Soc. 2011 Nov 09; 133(44):17544-7. PMID: 22003874.
    Citations: 13     Fields:    Translation:Cells
  66. Hagan CL, Kahne D. The reconstituted Escherichia coli Bam complex catalyzes multiple rounds of ß-barrel assembly. Biochemistry. 2011 Sep 06; 50(35):7444-6. PMID: 21823654.
    Citations: 23     Fields:    Translation:Cells
  67. Lupoli TJ, Tsukamoto H, Doud EH, Wang TS, Walker S, Kahne D. Transpeptidase-mediated incorporation of D-amino acids into bacterial peptidoglycan. J Am Chem Soc. 2011 Jul 20; 133(28):10748-51. PMID: 21682301.
    Citations: 27     Fields:    Translation:Cells
  68. Wang TS, Lupoli TJ, Sumida Y, Tsukamoto H, Wu Y, Rebets Y, Kahne DE, Walker S. Primer preactivation of peptidoglycan polymerases. J Am Chem Soc. 2011 Jun 08; 133(22):8528-30. PMID: 21568328.
    Citations: 7     Fields:    Translation:Cells
  69. Tsukamoto H, Kahne D. N-methylimidazolium chloride-catalyzed pyrophosphate formation: application to the synthesis of Lipid I and NDP-sugar donors. Bioorg Med Chem Lett. 2011 Sep 01; 21(17):5050-3. PMID: 21592792.
    Citations: 6     Fields:    Translation:Cells
  70. Zhang W, Ntai I, Bolla ML, Malcolmson SJ, Kahne D, Kelleher NL, Walsh CT. Nine enzymes are required for assembly of the pacidamycin group of peptidyl nucleoside antibiotics. J Am Chem Soc. 2011 Apr 13; 133(14):5240-3. PMID: 21417270.
    Citations: 14     Fields:    Translation:Cells
  71. Freinkman E, Chng SS, Kahne D. The complex that inserts lipopolysaccharide into the bacterial outer membrane forms a two-protein plug-and-barrel. Proc Natl Acad Sci U S A. 2011 Feb 08; 108(6):2486-91. PMID: 21257904.
    Citations: 64     Fields:    Translation:Cells
  72. Chimalakonda G, Ruiz N, Chng SS, Garner RA, Kahne D, Silhavy TJ. Lipoprotein LptE is required for the assembly of LptD by the beta-barrel assembly machine in the outer membrane of Escherichia coli. Proc Natl Acad Sci U S A. 2011 Feb 08; 108(6):2492-7. PMID: 21257909.
    Citations: 42     Fields:    Translation:Cells
  73. Hagan CL, Silhavy TJ, Kahne D. ß-Barrel membrane protein assembly by the Bam complex. Annu Rev Biochem. 2011; 80:189-210. PMID: 21370981.
    Citations: 113     Fields:    Translation:HumansCells
  74. Paradis-Bleau C, Markovski M, Uehara T, Lupoli TJ, Walker S, Kahne DE, Bernhardt TG. Lipoprotein cofactors located in the outer membrane activate bacterial cell wall polymerases. Cell. 2010 Dec 23; 143(7):1110-20. PMID: 21183074.
    Citations: 93     Fields:    Translation:Cells
  75. Sakurai K, Kahne D. Design and Synthesis of Functionalized Trisaccharides as p53-Peptide Mimics. Tetrahedron Lett. 2010 Jul 21; 51(29):3724-3727. PMID: 20676223.
    Citations:    Fields:    
  76. Fuse S, Tsukamoto H, Yuan Y, Wang TS, Zhang Y, Bolla M, Walker S, Sliz P, Kahne D. Functional and structural analysis of a key region of the cell wall inhibitor moenomycin. ACS Chem Biol. 2010 Jul 16; 5(7):701-11. PMID: 20496948.
    Citations: 6     Fields:    Translation:Cells
  77. Ruiz N, Chng SS, Hiniker A, Kahne D, Silhavy TJ. Nonconsecutive disulfide bond formation in an essential integral outer membrane protein. Proc Natl Acad Sci U S A. 2010 Jul 06; 107(27):12245-50. PMID: 20566849.
    Citations: 44     Fields:    Translation:Cells
  78. Chng SS, Gronenberg LS, Kahne D. Proteins required for lipopolysaccharide assembly in Escherichia coli form a transenvelope complex. Biochemistry. 2010 Jun 08; 49(22):4565-7. PMID: 20446753.
    Citations: 47     Fields:    Translation:Cells
  79. Zhang W, Bolla ML, Kahne D, Walsh CT. A three enzyme pathway for 2-amino-3-hydroxycyclopent-2-enone formation and incorporation in natural product biosynthesis. J Am Chem Soc. 2010 May 12; 132(18):6402-11. PMID: 20394362.
    Citations: 13     Fields:    Translation:Cells
  80. Silhavy TJ, Kahne D, Walker S. The bacterial cell envelope. Cold Spring Harb Perspect Biol. 2010 May; 2(5):a000414. PMID: 20452953.
    Citations: 343     Fields:    Translation:Cells
  81. Hagan CL, Kim S, Kahne D. Reconstitution of outer membrane protein assembly from purified components. Science. 2010 May 14; 328(5980):890-2. PMID: 20378773.
    Citations: 91     Fields:    Translation:Cells
  82. Chng SS, Ruiz N, Chimalakonda G, Silhavy TJ, Kahne D. Characterization of the two-protein complex in Escherichia coli responsible for lipopolysaccharide assembly at the outer membrane. Proc Natl Acad Sci U S A. 2010 Mar 23; 107(12):5363-8. PMID: 20203010.
    Citations: 70     Fields:    Translation:Cells
  83. Gronenberg LS, Kahne D. Development of an activity assay for discovery of inhibitors of lipopolysaccharide transport. J Am Chem Soc. 2010 Mar 03; 132(8):2518-9. PMID: 20136079.
    Citations: 7     Fields:    Translation:Cells
  84. Perlstein DL, Wang TS, Doud EH, Kahne D, Walker S. The role of the substrate lipid in processive glycan polymerization by the peptidoglycan glycosyltransferases. J Am Chem Soc. 2010 Jan 13; 132(1):48-9. PMID: 20017480.
    Citations: 18     Fields:    Translation:Animals
  85. Lupoli TJ, Taniguchi T, Wang TS, Perlstein DL, Walker S, Kahne DE. Studying a cell division amidase using defined peptidoglycan substrates. J Am Chem Soc. 2009 Dec 30; 131(51):18230-1. PMID: 19957935.
    Citations: 8     Fields:    Translation:Cells
  86. Chung HS, Yao Z, Goehring NW, Kishony R, Beckwith J, Kahne D. Rapid beta-lactam-induced lysis requires successful assembly of the cell division machinery. Proc Natl Acad Sci U S A. 2009 Dec 22; 106(51):21872-7. PMID: 19995973.
    Citations: 26     Fields:    
  87. Ostash B, Doud EH, Lin C, Ostash I, Perlstein DL, Fuse S, Wolpert M, Kahne D, Walker S. Complete characterization of the seventeen step moenomycin biosynthetic pathway. Biochemistry. 2009 Sep 22; 48(37):8830-41. PMID: 19640006.
    Citations: 15     Fields:    Translation:Cells
  88. Ruiz N, Kahne D, Silhavy TJ. Transport of lipopolysaccharide across the cell envelope: the long road of discovery. Nat Rev Microbiol. 2009 Sep; 7(9):677-83. PMID: 19633680.
    Citations: 79     Fields:    Translation:Cells
  89. Tanikawa T, Fridman M, Zhu W, Faulk B, Joseph IC, Kahne D, Wagner BK, Clemons PA. Using biological performance similarity to inform disaccharide library design. J Am Chem Soc. 2009 Apr 15; 131(14):5075-83. PMID: 19298063.
    Citations: 7     Fields:    Translation:AnimalsCells
  90. Hu Y, Al-Mestarihi A, Grimes CL, Kahne D, Bachmann BO. A unifying nitrososynthase involved in nitrosugar biosynthesis. J Am Chem Soc. 2008 Nov 26; 130(47):15756-7. PMID: 18983146.
    Citations: 9     Fields:    Translation:Cells
  91. Wang TS, Manning SA, Walker S, Kahne D. Isolated peptidoglycan glycosyltransferases from different organisms produce different glycan chain lengths. J Am Chem Soc. 2008 Oct 29; 130(43):14068-9. PMID: 18834124.
    Citations: 18     Fields:    Translation:Cells
  92. Yuan Y, Fuse S, Ostash B, Sliz P, Kahne D, Walker S. Structural analysis of the contacts anchoring moenomycin to peptidoglycan glycosyltransferases and implications for antibiotic design. ACS Chem Biol. 2008 Jul 18; 3(7):429-36. PMID: 18642800.
    Citations: 15     Fields:    Translation:Cells
  93. Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ. Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli. Proc Natl Acad Sci U S A. 2008 Apr 08; 105(14):5537-42. PMID: 18375759.
    Citations: 87     Fields:    Translation:Cells
  94. Perlstein DL, Zhang Y, Wang TS, Kahne DE, Walker S. The direction of glycan chain elongation by peptidoglycan glycosyltransferases. J Am Chem Soc. 2007 Oct 24; 129(42):12674-5. PMID: 17914829.
    Citations: 21     Fields:    Translation:Cells
  95. Sklar JG, Wu T, Kahne D, Silhavy TJ. Defining the roles of the periplasmic chaperones SurA, Skp, and DegP in Escherichia coli. Genes Dev. 2007 Oct 01; 21(19):2473-84. PMID: 17908933.
    Citations: 147     Fields:    Translation:Cells
  96. Barrett D, Wang TS, Yuan Y, Zhang Y, Kahne D, Walker S. Analysis of glycan polymers produced by peptidoglycan glycosyltransferases. J Biol Chem. 2007 Nov 02; 282(44):31964-71. PMID: 17704540.
    Citations: 28     Fields:    Translation:Cells
  97. Kim S, Malinverni JC, Sliz P, Silhavy TJ, Harrison SC, Kahne D. Structure and function of an essential component of the outer membrane protein assembly machine. Science. 2007 Aug 17; 317(5840):961-4. PMID: 17702946.
    Citations: 142     Fields:    Translation:Cells
  98. Leimkuhler C, Fridman M, Lupoli T, Walker S, Walsh CT, Kahne D. Characterization of rhodosaminyl transfer by the AknS/AknT glycosylation complex and its use in reconstituting the biosynthetic pathway of aclacinomycin A. J Am Chem Soc. 2007 Aug 29; 129(34):10546-50. PMID: 17685523.
    Citations: 5     Fields:    Translation:Cells
  99. Howard-Jones AR, Kruger RG, Lu W, Tao J, Leimkuhler C, Kahne D, Walsh CT. Kinetic analysis of teicoplanin glycosyltransferases and acyltransferase reveal ordered tailoring of aglycone scaffold to reconstitute mature teicoplanin. J Am Chem Soc. 2007 Aug 22; 129(33):10082-3. PMID: 17661468.
    Citations: 2     Fields:    Translation:Cells
  100. Fridman M, Balibar CJ, Lupoli T, Kahne D, Walsh CT, Garneau-Tsodikova S. Chemoenzymatic formation of novel aminocoumarin antibiotics by the enzymes CouN1 and CouN7. Biochemistry. 2007 Jul 17; 46(28):8462-71. PMID: 17580964.
    Citations: 5     Fields:    
  101. Sklar JG, Wu T, Gronenberg LS, Malinverni JC, Kahne D, Silhavy TJ. Lipoprotein SmpA is a component of the YaeT complex that assembles outer membrane proteins in Escherichia coli. Proc Natl Acad Sci U S A. 2007 Apr 10; 104(15):6400-5. PMID: 17404237.
    Citations: 110     Fields:    Translation:Cells
  102. Yuan Y, Barrett D, Zhang Y, Kahne D, Sliz P, Walker S. Crystal structure of a peptidoglycan glycosyltransferase suggests a model for processive glycan chain synthesis. Proc Natl Acad Sci U S A. 2007 Mar 27; 104(13):5348-53. PMID: 17360321.
    Citations: 32     Fields:    Translation:AnimalsCells
  103. Zhang Y, Fechter EJ, Wang TS, Barrett D, Walker S, Kahne DE. Synthesis of heptaprenyl-lipid IV to analyze peptidoglycan glycosyltransferases. J Am Chem Soc. 2007 Mar 21; 129(11):3080-1. PMID: 17323951.
    Citations: 23     Fields:    Translation:Cells
  104. Taylor JG, Li X, Oberthür M, Zhu W, Kahne DE. The total synthesis of moenomycin A. J Am Chem Soc. 2006 Nov 29; 128(47):15084-5. PMID: 17117848.
    Citations: 13     Fields:    Translation:Cells
  105. Adachi M, Zhang Y, Leimkuhler C, Sun B, LaTour JV, Kahne DE. Degradation and reconstruction of moenomycin A and derivatives: dissecting the function of the isoprenoid chain. J Am Chem Soc. 2006 Nov 01; 128(43):14012-3. PMID: 17061868.
    Citations: 9     Fields:    Translation:Cells
  106. Sakurai K, Schubert C, Kahne D. Crystallographic analysis of an 8-mer p53 peptide analogue complexed with MDM2. J Am Chem Soc. 2006 Aug 30; 128(34):11000-1. PMID: 16925398.
    Citations: 10     Fields:    Translation:Cells
  107. Wu T, McCandlish AC, Gronenberg LS, Chng SS, Silhavy TJ, Kahne D. Identification of a protein complex that assembles lipopolysaccharide in the outer membrane of Escherichia coli. Proc Natl Acad Sci U S A. 2006 Aug 01; 103(31):11754-9. PMID: 16861298.
    Citations: 120     Fields:    Translation:Cells
  108. Ruiz N, Wu T, Kahne D, Silhavy TJ. Probing the barrier function of the outer membrane with chemical conditionality. ACS Chem Biol. 2006 Jul 21; 1(6):385-95. PMID: 17163776.
    Citations: 30     Fields:    Translation:Cells
  109. Garneau-Tsodikova S, Stapon A, Kahne D, Walsh CT. Installation of the pyrrolyl-2-carboxyl pharmacophore by CouN1 and CouN7 in the late biosynthetic steps of the aminocoumarin antibiotics clorobiocin and coumermycin A1. Biochemistry. 2006 Jul 18; 45(28):8568-78. PMID: 16834331.
    Citations: 3     Fields:    Translation:Cells
  110. Malinverni JC, Werner J, Kim S, Sklar JG, Kahne D, Misra R, Silhavy TJ. YfiO stabilizes the YaeT complex and is essential for outer membrane protein assembly in Escherichia coli. Mol Microbiol. 2006 Jul; 61(1):151-64. PMID: 16824102.
    Citations: 102     Fields:    Translation:Cells
  111. Ruiz N, Kahne D, Silhavy TJ. Advances in understanding bacterial outer-membrane biogenesis. Nat Rev Microbiol. 2006 Jan; 4(1):57-66. PMID: 16357861.
    Citations: 142     Fields:    Translation:Cells
  112. Yuan Y, Chung HS, Leimkuhler C, Walsh CT, Kahne D, Walker S. In vitro reconstitution of EryCIII activity for the preparation of unnatural macrolides. J Am Chem Soc. 2005 Oct 19; 127(41):14128-9. PMID: 16218575.
    Citations: 15     Fields:    Translation:Cells
  113. Oberthür M, Leimkuhler C, Kruger RG, Lu W, Walsh CT, Kahne D. A systematic investigation of the synthetic utility of glycopeptide glycosyltransferases. J Am Chem Soc. 2005 Aug 03; 127(30):10747-52. PMID: 16045364.
    Citations: 10     Fields:    Translation:Cells
  114. Ngundi MM, Taitt CR, McMurry SA, Kahne D, Ligler FS. Detection of bacterial toxins with monosaccharide arrays. Biosens Bioelectron. 2006 Jan 15; 21(7):1195-201. PMID: 15946840.
    Citations: 4     Fields:    Translation:Cells
  115. Lu W, Leimkuhler C, Gatto GJ, Kruger RG, Oberthür M, Kahne D, Walsh CT. AknT is an activating protein for the glycosyltransferase AknS in L-aminodeoxysugar transfer to the aglycone of aclacinomycin A. Chem Biol. 2005 May; 12(5):527-34. PMID: 15911373.
    Citations: 16     Fields:    Translation:Cells
  116. Ruiz N, Falcone B, Kahne D, Silhavy TJ. Chemical conditionality: a genetic strategy to probe organelle assembly. Cell. 2005 Apr 22; 121(2):307-17. PMID: 15851036.
    Citations: 107     Fields:    Translation:Cells
  117. Wu T, Malinverni J, Ruiz N, Kim S, Silhavy TJ, Kahne D. Identification of a multicomponent complex required for outer membrane biogenesis in Escherichia coli. Cell. 2005 Apr 22; 121(2):235-45. PMID: 15851030.
    Citations: 236     Fields:    Translation:Cells
  118. Pacholec M, Freel Meyers CL, Oberthür M, Kahne D, Walsh CT. Characterization of the aminocoumarin ligase SimL from the simocyclinone pathway and tandem incubation with NovM,P,N from the novobiocin pathway. Biochemistry. 2005 Mar 29; 44(12):4949-56. PMID: 15779922.
    Citations: 8     Fields:    Translation:Cells
  119. Leimkuhler C, Chen L, Barrett D, Panzone G, Sun B, Falcone B, Oberthür M, Donadio S, Walker S, Kahne D. Differential inhibition of Staphylococcus aureus PBP2 by glycopeptide antibiotics. J Am Chem Soc. 2005 Mar 16; 127(10):3250-1. PMID: 15755121.
    Citations: 8     Fields:    Translation:Cells
  120. Barrett D, Leimkuhler C, Chen L, Walker D, Kahne D, Walker S. Kinetic characterization of the glycosyltransferase module of Staphylococcus aureus PBP2. J Bacteriol. 2005 Mar; 187(6):2215-7. PMID: 15743972.
    Citations: 14     Fields:    Translation:Cells
  121. Kahne D, Leimkuhler C, Lu W, Walsh C. Glycopeptide and lipoglycopeptide antibiotics. Chem Rev. 2005 Feb; 105(2):425-48. PMID: 15700951.
    Citations: 78     Fields:    Translation:Cells
  122. Kruger RG, Lu W, Oberthür M, Tao J, Kahne D, Walsh CT. Tailoring of glycopeptide scaffolds by the acyltransferases from the teicoplanin and A-40,926 biosynthetic operons. Chem Biol. 2005 Jan; 12(1):131-40. PMID: 15664522.
    Citations: 7     Fields:    Translation:Cells
  123. Kagan E, Ragupathi G, Yi SS, Reis CA, Gildersleeve J, Kahne D, Clausen H, Danishefsky SJ, Livingston PO. Comparison of antigen constructs and carrier molecules for augmenting the immunogenicity of the monosaccharide epithelial cancer antigen Tn. Cancer Immunol Immunother. 2005 May; 54(5):424-30. PMID: 15625606.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  124. Sakurai K, Chung HS, Kahne D. Use of a retroinverso p53 peptide as an inhibitor of MDM2. J Am Chem Soc. 2004 Dec 22; 126(50):16288-9. PMID: 15600307.
    Citations: 12     Fields:    Translation:Cells
  125. Freel Meyers CL, Oberthür M, Heide L, Kahne D, Walsh CT. Assembly of dimeric variants of coumermycins by tandem action of the four biosynthetic enzymes CouL, CouM, CouP, and NovN. Biochemistry. 2004 Nov 30; 43(47):15022-36. PMID: 15554710.
    Citations: 4     Fields:    Translation:Cells
  126. Oberthür M, Leimkuhler C, Kahne D. A practical method for the stereoselective generation of beta-2-deoxy glycosyl phosphates. Org Lett. 2004 Aug 19; 6(17):2873-6. PMID: 15330636.
    Citations: 4     Fields:    Translation:Cells
  127. Lee HY, Chung HS, Hang C, Khosla C, Walsh CT, Kahne D, Walker S. Reconstitution and characterization of a new desosaminyl transferase, EryCIII, from the erythromycin biosynthetic pathway. J Am Chem Soc. 2004 Aug 18; 126(32):9924-5. PMID: 15303858.
    Citations: 4     Fields:    Translation:Cells
  128. Lu W, Leimkuhler C, Oberthür M, Kahne D, Walsh CT. AknK is an L-2-deoxyfucosyltransferase in the biosynthesis of the anthracycline aclacinomycin A. Biochemistry. 2004 Apr 20; 43(15):4548-58. PMID: 15078101.
    Citations: 10     Fields:    Translation:Cells
  129. Lu W, Oberthür M, Leimkuhler C, Tao J, Kahne D, Walsh CT. Characterization of a regiospecific epivancosaminyl transferase GtfA and enzymatic reconstitution of the antibiotic chloroeremomycin. Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13):4390-5. PMID: 15070728.
    Citations: 6     Fields:    Translation:Cells
  130. Howorka S, Nam J, Bayley H, Kahne D. Stochastic detection of monovalent and bivalent protein-ligand interactions. Angew Chem Int Ed Engl. 2004 Feb 06; 43(7):842-6. PMID: 14767954.
    Citations: 14     Fields:    Translation:Cells
  131. Freel Meyers CL, Oberthür M, Xu H, Heide L, Kahne D, Walsh CT. Characterization of NovP and NovN: completion of novobiocin biosynthesis by sequential tailoring of the noviosyl ring. Angew Chem Int Ed Engl. 2004 Jan; 43(1):67-70. PMID: 14694473.
    Citations: 11     Fields:    Translation:Cells
  132. Basu A, Kahne D. Overcoming degeneracy in carbohydrate recognition. Angew Chem Int Ed Engl. 2003 Jun 06; 42(22):2504-6. PMID: 12800171.
    Citations: 1     Fields:    Translation:Cells
  133. Chen L, Walker D, Sun B, Hu Y, Walker S, Kahne D. Vancomycin analogues active against vanA-resistant strains inhibit bacterial transglycosylase without binding substrate. Proc Natl Acad Sci U S A. 2003 May 13; 100(10):5658-63. PMID: 12714684.
    Citations: 38     Fields:    Translation:Cells
  134. Freel Meyers CL, Oberthür M, Anderson JW, Kahne D, Walsh CT. Initial characterization of novobiocic acid noviosyl transferase activity of NovM in biosynthesis of the antibiotic novobiocin. Biochemistry. 2003 Apr 15; 42(14):4179-89. PMID: 12680772.
    Citations: 5     Fields:    Translation:Cells
  135. Losey HC, Jiang J, Biggins JB, Oberthür M, Ye XY, Dong SD, Kahne D, Thorson JS, Walsh CT. Incorporation of glucose analogs by GtfE and GtfD from the vancomycin biosynthetic pathway to generate variant glycopeptides. Chem Biol. 2002 Dec; 9(12):1305-14. PMID: 12498883.
    Citations: 15     Fields:    Translation:Cells
  136. Dong SD, Oberthür M, Losey HC, Anderson JW, Eggert US, Peczuh MW, Walsh CT, Kahne D. The structural basis for induction of VanB resistance. J Am Chem Soc. 2002 Aug 07; 124(31):9064-5. PMID: 12149006.
    Citations: 13     Fields:    Translation:Cells
  137. Sun B, Chen Z, Eggert US, Shaw SJ, LaTour JV, Kahne D. Hybrid glycopeptide antibiotics. J Am Chem Soc. 2001 Dec 19; 123(50):12722-3. PMID: 11741455.
    Citations: 5     Fields:    Translation:Cells
  138. Specht KM, Nam J, Ho DM, Berova N, Kondru RK, Beratan DN, Wipf P, Pascal RA, Kahne D. Determining absolute configuration in flexible molecules: a case study. J Am Chem Soc. 2001 Sep 19; 123(37):8961-6. PMID: 11552802.
    Citations: 2     Fields:    Translation:Cells
  139. Eggert US, Ruiz N, Falcone BV, Branstrom AA, Goldman RC, Silhavy TJ, Kahne D. Genetic basis for activity differences between vancomycin and glycolipid derivatives of vancomycin. Science. 2001 Oct 12; 294(5541):361-4. PMID: 11520949.
    Citations: 41     Fields:    Translation:Cells
  140. Losey HC, Peczuh MW, Chen Z, Eggert US, Dong SD, Pelczer I, Kahne D, Walsh CT. Tandem action of glycosyltransferases in the maturation of vancomycin and teicoplanin aglycones: novel glycopeptides. Biochemistry. 2001 Apr 17; 40(15):4745-55. PMID: 11294642.
    Citations: 15     Fields:    Translation:Cells
  141. Ye XY, Lo MC, Brunner L, Walker D, Kahne D, Walker S. Better substrates for bacterial transglycosylases. J Am Chem Soc. 2001 Apr 04; 123(13):3155-6. PMID: 11457035.
    Citations: 42     Fields:    Translation:Cells
  142. Horan N, Yan L, Isobe H, Whitesides GM, Kahne D. Nonstatistical binding of a protein to clustered carbohydrates. Proc Natl Acad Sci U S A. 1999 Oct 12; 96(21):11782-6. PMID: 10518527.
    Citations: 21     Fields:    Translation:Cells
  143. Ge M, Chen Z, Onishi HR, Kohler J, Silver LL, Kerns R, Fukuzawa S, Thompson C, Kahne D. Vancomycin derivatives that inhibit peptidoglycan biosynthesis without binding D-Ala-D-Ala. Science. 1999 Apr 16; 284(5413):507-11. PMID: 10205063.
    Citations: 42     Fields:    Translation:Cells
  144. Bowe CL, Mokhtarzadeh L, Venkatesan P, Babu S, Axelrod HR, Sofia MJ, Kakarla R, Chan TY, Kim JS, Lee HJ, Amidon GL, Choe SY, Walker S, Kahne D. Design of compounds that increase the absorption of polar molecules. Proc Natl Acad Sci U S A. 1997 Oct 28; 94(22):12218-23. PMID: 9342389.
    Citations: 7     Fields:    Translation:AnimalsCells
  145. Liang R, Loebach J, Horan N, Ge M, Thompson C, Yan L, Kahne D. Polyvalent binding to carbohydrates immobilized on an insoluble resin. Proc Natl Acad Sci U S A. 1997 Sep 30; 94(20):10554-9. PMID: 9380673.
    Citations: 5     Fields:    Translation:Cells
  146. Kahne D. Combinatorial approaches to carbohydrates. Curr Opin Chem Biol. 1997 Jun; 1(1):130-5. PMID: 9667837.
    Citations: 1     Fields:    Translation:Cells
  147. Liang R, Yan L, Loebach J, Ge M, Uozumi Y, Sekanina K, Horan N, Gildersleeve J, Thompson C, Smith A, Biswas K, Still WC, Kahne D. Parallel synthesis and screening of a solid phase carbohydrate library. Science. 1996 Nov 29; 274(5292):1520-2. PMID: 8929411.
    Citations: 12     Fields:    Translation:Cells
  148. Walker S, Sofia MJ, Kakarla R, Kogan NA, Wierichs L, Longley CB, Bruker K, Axelrod HR, Midha S, Babu S, Kahne D. Cationic facial amphiphiles: a promising class of transfection agents. Proc Natl Acad Sci U S A. 1996 Feb 20; 93(4):1585-90. PMID: 8643675.
    Citations: 9     Fields:    Translation:AnimalsCells
  149. Kahne D. Strategies for the design of minor groove binders: a re-evaluation based on the emergence of site-selective carbohydrate binders. Chem Biol. 1995 Jan; 2(1):7-12. PMID: 9383398.
    Citations: 3     Fields:    Translation:Cells
  150. Silva DJ, Kraml CM, Kahne D. Use of triethylene glycol to mimic oligosaccharides: design and synthesis of a ligand based on chromomycin A3. Bioorg Med Chem. 1994 Nov; 2(11):1251-9. PMID: 7757421.
    Citations:    Fields:    Translation:Cells
  151. Shigeta R, Forest K, Yan L, Kahne D, Schutt CE. Isomorphous binding of mercury-substituted thiosaccharides to pertussis toxin crystals yields crystallographic phases. Acta Crystallogr D Biol Crystallogr. 1994 Jan 01; 50(Pt 1):71-4. PMID: 15299478.
    Citations:    Fields:    
  152. Silva DJ, Goodnow R, Kahne D. The sugars in chromomycin A3 stabilize the Mg(2+)-dimer complex. Biochemistry. 1993 Jan 19; 32(2):463-71. PMID: 8422355.
    Citations: 5     Fields:    Translation:Cells
  153. Walker S, Landovitz R, Ding WD, Ellestad GA, Kahne D. Cleavage behavior of calicheamicin gamma 1 and calicheamicin T. Proc Natl Acad Sci U S A. 1992 May 15; 89(10):4608-12. PMID: 1584797.
    Citations: 13     Fields:    Translation:Cells
  154. Pine MB, Kahne D, Jaski B, Apstein CS, Thorp K, Abelmann WH. Sodium permeability and myocardial resistance to cell swelling during metabolic blockade. Am J Physiol. 1980 Jul; 239(1):H31-9. PMID: 7396015.
    Citations: 5     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.