Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Senthil Kumar Muthuswamy, Ph.D.

Title
Institution
Department
Address
Phone
Fax
Profile Picture
Other Positions
Title
Institution
Department

Biography
McMaster University, CanadaPh.D.09/1995Molecular Biology
1989 - 1995
Canadian International Development Agency Scholar
2002 - 2004
V Foundation Early Investigator Scholar
2004 - 2007
Rita Allen Scholar
2008 - 2013
Era of Hope Scholar Award
2010 - 2010
Outstanding Young Invesitgator Award

Overview

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01CA098830 (MUTHUSWAMY, SENTHIL K) Mar 1, 2003 - Dec 31, 2014
    NIH/NCI
    Cell polarity pathways and ErbB2 mediated tumorigenesis
    Role: Principal Investigator
  2. R56CA098830 (MUTHUSWAMY, SENTHIL K) Mar 1, 2003 - Jan 31, 2009
    NIH/NCI
    Mechanisms by which Polarity Proteins Regulate Initiation and Progression of Brea
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Saito Y, Li L, Coyaud E, Luna A, Sander C, Raught B, Asara JM, Brown M, Muthuswamy SK. LLGL2 rescues nutrient stress by promoting leucine uptake in ER+ breast cancer. Nature. 2019 May; 569(7755):275-279. PMID: 30996345.
    Citations:    
  2. Natividad RJ, Lalli ML, Muthuswamy SK, Asthagiri AR. Golgi Stabilization, Not Its Front-Rear Bias, Is Associated with EMT-Enhanced Fibrillar Migration. Biophys J. 2018 Nov 20; 115(10):2067-2077. PMID: 30366626.
    Citations:    Fields:    
  3. Sonzogni O, Haynes J, Seifried LA, Kamel YM, Huang K, BeGora MD, Yeung FA, Robert-Tissot C, Heng YJ, Yuan X, Wulf GM, Kron KJ, Wagenblast E, Lupien M, Kislinger T, Hannon GJ, Muthuswamy SK. Reporters to mark and eliminate basal or luminal epithelial cells in culture and in vivo. PLoS Biol. 2018 06; 16(6):e2004049. PMID: 29924804.
    Citations:    Fields:    
  4. Muthuswamy SK. Organoid Models of Cancer Explode with Possibilities. Cell Stem Cell. 2018 03 01; 22(3):290-291. PMID: 29499146.
    Citations: 1     Fields:    
  5. Saito Y, Desai RR, Muthuswamy SK. Reinterpreting polarity and cancer: The changing landscape from tumor suppression to tumor promotion. Biochim Biophys Acta Rev Cancer. 2018 Apr; 1869(2):103-116. PMID: 29369778.
    Citations:    Translation:HumansAnimalsCells
  6. Gilles ME, Hao L, Huang L, Rupaimoole R, Lopez-Casas PP, Pulver E, Jeong JC, Muthuswamy SK, Hidalgo M, Bhatia SN, Slack FJ. Personalized RNA Medicine for Pancreatic Cancer. Clin Cancer Res. 2018 04 01; 24(7):1734-1747. PMID: 29330203.
    Citations: 2     Fields:    
  7. Götz M, Muthuswamy SK. Editorial overview: Cell differentiation and development: New kids in the block-new tools and concepts opening new doors in development. Curr Opin Cell Biol. 2017 12; 49:iv-v. PMID: 29463399.
    Citations:    Fields:    
  8. Dai X, Gan W, Li X, Wang S, Zhang W, Huang L, Liu S, Zhong Q, Guo J, Zhang J, Chen T, Shimizu K, Beca F, Blattner M, Vasudevan D, Buckley DL, Qi J, Buser L, Liu P, Inuzuka H, Beck AH, Wang L, Wild PJ, Garraway LA, Rubin MA, Barbieri CE, Wong KK, Muthuswamy SK, Huang J, Chen Y, Bradner JE, Wei W. Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4. Nat Med. 2017 Sep; 23(9):1063-1071. PMID: 28805820.
    Citations: 18     Fields:    Translation:HumansCells
  9. Muthuswamy SK. Bringing together the organoid field: from early beginnings to the road ahead. Development. 2017 03 15; 144(6):963-967. PMID: 28292842.
    Citations: 1     Fields:    Translation:HumansAnimals
  10. Milano DF, Natividad RJ, Saito Y, Luo CY, Muthuswamy SK, Asthagiri AR. Positive Quantitative Relationship between EMT and Contact-Initiated Sliding on Fiber-like Tracks. Biophys J. 2016 Oct 04; 111(7):1569-1574. PMID: 27705778.
    Citations:    Fields:    Translation:HumansCells
  11. Zheng W, Umitsu M, Jagan I, Tran CW, Ishiyama N, BeGora M, Araki K, Ohashi PS, Ikura M, Muthuswamy SK. An interaction between Scribble and the NADPH oxidase complex controls M1 macrophage polarization and function. Nat Cell Biol. 2016 Nov; 18(11):1244-1252. PMID: 27694890.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  12. Baker L, BeGora M, Au Yeung F, Feigin ME, Rosenberg AZ, Lowe SW, Kislinger T, Muthuswamy SK. Scribble is required for pregnancy-induced alveologenesis in the adult mammary gland. Development. 2016 Jul 1; 143(13):e1.1. PMID: 27381229.
    Citations:    
  13. Baker L, BeGora M, Au Yeung F, Feigin ME, Rosenberg AZ, Lowe SW, Kislinger T, Muthuswamy SK. Scribble is required for pregnancy-induced alveologenesis in the adult mammary gland. J Cell Sci. 2016 06 15; 129(12):2307-15. PMID: 27179074.
    Citations: 1     Fields:    Translation:AnimalsCells
  14. Milano DF, Ngai NA, Muthuswamy SK, Asthagiri AR. Regulators of Metastasis Modulate the Migratory Response to Cell Contact under Spatial Confinement. Biophys J. 2016 04 26; 110(8):1886-1895. PMID: 27119647.
    Citations: 3     Fields:    Translation:HumansCells
  15. Huang L, Holtzinger A, Jagan I, BeGora M, Lohse I, Ngai N, Nostro C, Wang R, Muthuswamy LB, Crawford HC, Arrowsmith C, Kalloger SE, Renouf DJ, Connor AA, Cleary S, Schaeffer DF, Roehrl M, Tsao MS, Gallinger S, Keller G, Muthuswamy SK. Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell- and patient-derived tumor organoids. Nat Med. 2015 Nov; 21(11):1364-71. PMID: 26501191.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  16. Edwards AM, Arrowsmith CH, Bountra C, Bunnage ME, Feldmann M, Knight JC, Patel DD, Prinos P, Taylor MD, Sundström M. Preclinical target validation using patient-derived cells. Nat Rev Drug Discov. 2015 Mar; 14(3):149-50. PMID: 25722227.
    Citations: 11     Fields:    Translation:HumansCells
  17. Ramesh M, Krishnan N, Muthuswamy SK, Tonks NK. A novel phosphatidic acid-protein-tyrosine phosphatase D2 axis is essential for ERBB2 signaling in mammary epithelial cells. J Biol Chem. 2015 Apr 10; 290(15):9646-59. PMID: 25681440.
    Citations: 3     Fields:    Translation:HumansCells
  18. Krishnan N, Koveal D, Miller DH, Xue B, Akshinthala SD, Kragelj J, Jensen MR, Gauss CM, Page R, Blackledge M, Muthuswamy SK, Peti W, Tonks NK. Targeting the disordered C terminus of PTP1B with an allosteric inhibitor. Nat Chem Biol. 2014 Jul; 10(7):558-66. PMID: 24845231.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  19. Feigin ME, Akshinthala SD, Araki K, Rosenberg AZ, Muthuswamy LB, Martin B, Lehmann BD, Berman HK, Pietenpol JA, Cardiff RD, Muthuswamy SK. Mislocalization of the cell polarity protein scribble promotes mammary tumorigenesis and is associated with basal breast cancer. Cancer Res. 2014 Jun 01; 74(11):3180-94. PMID: 24662921.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  20. Feigin ME, Xue B, Hammell MC, Muthuswamy SK. G-protein-coupled receptor GPR161 is overexpressed in breast cancer and is a promoter of cell proliferation and invasion. Proc Natl Acad Sci U S A. 2014 Mar 18; 111(11):4191-6. PMID: 24599592.
    Citations: 16     Fields:    Translation:HumansCells
  21. Xue B, Krishnamurthy K, Allred DC, Muthuswamy SK. Loss of Par3 promotes breast cancer metastasis by compromising cell-cell cohesion. Nat Cell Biol. 2013 Feb; 15(2):189-200. PMID: 23263278.
    Citations: 58     Fields:    Translation:AnimalsCells
  22. Wang H, Lacoche S, Huang L, Xue B, Muthuswamy SK. Rotational motion during three-dimensional morphogenesis of mammary epithelial acini relates to laminin matrix assembly. Proc Natl Acad Sci U S A. 2013 Jan 02; 110(1):163-8. PMID: 23248267.
    Citations: 35     Fields:    Translation:HumansCells
  23. Muthuswamy SK. Autocrine prolactin: an emerging market for homegrown (prolactin) despite the imports. Genes Dev. 2012 Oct 15; 26(20):2253-8. PMID: 23070811.
    Citations: 1     Fields:    Translation:Animals
  24. Yang Z, Xue B, Umitsu M, Ikura M, Muthuswamy SK, Neel BG. The signaling adaptor GAB1 regulates cell polarity by acting as a PAR protein scaffold. Mol Cell. 2012 Aug 10; 47(3):469-83. PMID: 22883624.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  25. Muthuswamy SK, Xue B. Cell polarity as a regulator of cancer cell behavior plasticity. Annu Rev Cell Dev Biol. 2012; 28:599-625. PMID: 22881459.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  26. Yu M, Lin G, Arshadi N, Kalatskaya I, Xue B, Haider S, Nguyen F, Boutros PC, Elson A, Muthuswamy LB, Tonks NK, Muthuswamy SK. Expression profiling during mammary epithelial cell three-dimensional morphogenesis identifies PTPRO as a novel regulator of morphogenesis and ErbB2-mediated transformation. Mol Cell Biol. 2012 Oct; 32(19):3913-24. PMID: 22851698.
    Citations: 15     Fields:    Translation:HumansCells
  27. Chatterjee S, Seifried L, Feigin ME, Gibbons DL, Scuoppo C, Lin W, Rizvi ZH, Lind E, Dissanayake D, Kurie J, Ohashi P, Muthuswamy SK. Dysregulation of cell polarity proteins synergize with oncogenes or the microenvironment to induce invasive behavior in epithelial cells. PLoS One. 2012; 7(4):e34343. PMID: 22529912.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  28. Anczuków O, Rosenberg AZ, Akerman M, Das S, Zhan L, Karni R, Muthuswamy SK, Krainer AR. The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation. Nat Struct Mol Biol. 2012 Jan 15; 19(2):220-8. PMID: 22245967.
    Citations: 102     Fields:    Translation:HumansAnimalsCells
  29. Lin G, Aranda V, Muthuswamy SK, Tonks NK. Identification of PTPN23 as a novel regulator of cell invasion in mammary epithelial cells from a loss-of-function screen of the 'PTP-ome'. Genes Dev. 2011 Jul 01; 25(13):1412-25. PMID: 21724833.
    Citations: 25     Fields:    Translation:HumansCells
  30. Simpson DR, Yu M, Zheng S, Zhao Z, Muthuswamy SK, Tansey WP. Epithelial cell organization suppresses Myc function by attenuating Myc expression. Cancer Res. 2011 Jun 01; 71(11):3822-30. PMID: 21610111.
    Citations: 4     Fields:    Translation:HumansCells
  31. Muthuswamy SK. Trastuzumab resistance: all roads lead to SRC. Nat Med. 2011 Apr; 17(4):416-8. PMID: 21475230.
    Citations: 12     Fields:    Translation:HumansCells
  32. Keyes WM, Pecoraro M, Aranda V, Vernersson-Lindahl E, Li W, Vogel H, Guo X, Garcia EL, Michurina TV, Enikolopov G, Muthuswamy SK, Mills AA. ?Np63a is an oncogene that targets chromatin remodeler Lsh to drive skin stem cell proliferation and tumorigenesis. Cell Stem Cell. 2011 Feb 04; 8(2):164-76. PMID: 21295273.
    Citations: 84     Fields:    Translation:HumansAnimalsCells
  33. Muthuswamy SK. 3D culture reveals a signaling network. Breast Cancer Res. 2011 Jan 27; 13(1):103. PMID: 21349209.
    Citations: 5     Fields:    Translation:Animals
  34. Arias-Romero LE, Villamar-Cruz O, Pacheco A, Kosoff R, Huang M, Muthuswamy SK, Chernoff J. A Rac-Pak signaling pathway is essential for ErbB2-mediated transformation of human breast epithelial cancer cells. Oncogene. 2010 Oct 28; 29(43):5839-49. PMID: 20711231.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  35. Cabodi S, Tinnirello A, Bisaro B, Tornillo G, del Pilar Camacho-Leal M, Forni G, Cojoca R, Iezzi M, Amici A, Montani M, Eva A, Di Stefano P, Muthuswamy SK, Tarone G, Turco E, Defilippi P. p130Cas is an essential transducer element in ErbB2 transformation. FASEB J. 2010 Oct; 24(10):3796-808. PMID: 20505116.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  36. Ling C, Zuo D, Xue B, Muthuswamy S, Muller WJ. A novel role for 14-3-3sigma in regulating epithelial cell polarity. Genes Dev. 2010 May; 24(9):947-56. PMID: 20439433.
    Citations: 20     Fields:    Translation:AnimalsCells
  37. Huang L, Muthuswamy SK. Polarity protein alterations in carcinoma: a focus on emerging roles for polarity regulators. Curr Opin Genet Dev. 2010 Feb; 20(1):41-50. PMID: 20093003.
    Citations: 50     Fields:    Translation:HumansAnimals
  38. Muthuswamy S. Senthil Muthuswamy: a new road map for cancer. Interview by Caitlin Sedwick. J Cell Biol. 2009 Oct 19; 187(2):152-3. PMID: 19841132.
    Citations:    Fields:    Translation:HumansAnimals
  39. Lucs AV, Muller WJ, Muthuswamy SK. Shc is required for ErbB2-induced inhibition of apoptosis but is dispensable for cell proliferation and disruption of cell polarity. Oncogene. 2010 Jan 14; 29(2):174-87. PMID: 19826412.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  40. Feigin ME, Muthuswamy SK. Polarity proteins regulate mammalian cell-cell junctions and cancer pathogenesis. Curr Opin Cell Biol. 2009 Oct; 21(5):694-700. PMID: 19729289.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  41. Silva JM, Ezhkova E, Silva J, Heart S, Castillo M, Campos Y, Castro V, Bonilla F, Cordon-Cardo C, Muthuswamy SK, Powers S, Fuchs E, Hannon GJ. Cyfip1 is a putative invasion suppressor in epithelial cancers. Cell. 2009 Jun 12; 137(6):1047-61. PMID: 19524508.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  42. Muthuswamy SK. A new tumor suppressor that regulates tissue architecture. PLoS Med. 2009 May 26; 6(5):e1000073. PMID: 19536324.
    Citations: 4     Fields:    Translation:Humans
  43. Zavadil J, Haley J, Kalluri R, Muthuswamy SK, Thompson E. Epithelial-mesenchymal transition. Cancer Res. 2008 Dec 01; 68(23):9574-7. PMID: 19047131.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  44. Zhan L, Rosenberg A, Bergami KC, Yu M, Xuan Z, Jaffe AB, Allred C, Muthuswamy SK. Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma. Cell. 2008 Nov 28; 135(5):865-78. PMID: 19041750.
    Citations: 163     Fields:    Translation:HumansAnimalsCells
  45. Aranda V, Nolan ME, Muthuswamy SK. Par complex in cancer: a regulator of normal cell polarity joins the dark side. Oncogene. 2008 Nov 24; 27(55):6878-87. PMID: 19029931.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  46. Feigin ME, Muthuswamy SK. ErbB receptors and cell polarity: new pathways and paradigms for understanding cell migration and invasion. Exp Cell Res. 2009 Feb 15; 315(4):707-16. PMID: 19022245.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  47. Nolan ME, Aranda V, Lee S, Lakshmi B, Basu S, Allred DC, Muthuswamy SK. The polarity protein Par6 induces cell proliferation and is overexpressed in breast cancer. Cancer Res. 2008 Oct 15; 68(20):8201-9. PMID: 18922891.
    Citations: 55     Fields:    Translation:HumansCells
  48. Xiang B, Chatti K, Qiu H, Lakshmi B, Krasnitz A, Hicks J, Yu M, Miller WT, Muthuswamy SK. Brk is coamplified with ErbB2 to promote proliferation in breast cancer. Proc Natl Acad Sci U S A. 2008 Aug 26; 105(34):12463-8. PMID: 18719096.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  49. Guix M, Granja Nde M, Meszoely I, Adkins TB, Wieman BM, Frierson KE, Sanchez V, Sanders ME, Grau AM, Mayer IA, Pestano G, Shyr Y, Muthuswamy S, Calvo B, Krontiras H, Krop IE, Kelley MC, Arteaga CL. Short preoperative treatment with erlotinib inhibits tumor cell proliferation in hormone receptor-positive breast cancers. J Clin Oncol. 2008 Feb 20; 26(6):897-906. PMID: 18180460.
    Citations: 30     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  50. Ibarra I, Erlich Y, Muthuswamy SK, Sachidanandam R, Hannon GJ. A role for microRNAs in maintenance of mouse mammary epithelial progenitor cells. Genes Dev. 2007 Dec 15; 21(24):3238-43. PMID: 18079172.
    Citations: 93     Fields:    Translation:AnimalsCells
  51. Tonks NK, Muthuswamy SK. A brake becomes an accelerator: PTP1B--a new therapeutic target for breast cancer. Cancer Cell. 2007 Mar; 11(3):214-6. PMID: 17349579.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  52. Aranda V, Haire T, Nolan ME, Calarco JP, Rosenberg AZ, Fawcett JP, Pawson T, Muthuswamy SK. Par6-aPKC uncouples ErbB2 induced disruption of polarized epithelial organization from proliferation control. Nat Cell Biol. 2006 Nov; 8(11):1235-45. PMID: 17060907.
    Citations: 116     Fields:    Translation:AnimalsCells
  53. Reginato MJ, Muthuswamy SK. Illuminating the center: mechanisms regulating lumen formation and maintenance in mammary morphogenesis. J Mammary Gland Biol Neoplasia. 2006 Oct; 11(3-4):205-11. PMID: 17115263.
    Citations: 16     Fields:    Translation:HumansAnimals
  54. Muthuswamy SK. ErbB2 makes beta 4 integrin an accomplice in tumorigenesis. Cell. 2006 Aug 11; 126(3):443-5. PMID: 16901776.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  55. Wang SE, Narasanna A, Perez-Torres M, Xiang B, Wu FY, Yang S, Carpenter G, Gazdar AF, Muthuswamy SK, Arteaga CL. HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and resistance to EGFR tyrosine kinase inhibitors. Cancer Cell. 2006 Jul; 10(1):25-38. PMID: 16843263.
    Citations: 154     Fields:    Translation:HumansAnimalsCells
  56. Zhan L, Xiang B, Muthuswamy SK. Controlled activation of ErbB1/ErbB2 heterodimers promote invasion of three-dimensional organized epithelia in an ErbB1-dependent manner: implications for progression of ErbB2-overexpressing tumors. Cancer Res. 2006 May 15; 66(10):5201-8. PMID: 16707444.
    Citations: 27     Fields:    Translation:HumansCells
  57. Xiang B, Muthuswamy SK. Using three-dimensional acinar structures for molecular and cell biological assays. Methods Enzymol. 2006; 406:692-701. PMID: 16472698.
    Citations: 24     Fields:    Translation:HumansCells
  58. Reginato MJ, Mills KR, Becker EB, Lynch DK, Bonni A, Muthuswamy SK, Brugge JS. Bim regulation of lumen formation in cultured mammary epithelial acini is targeted by oncogenes. Mol Cell Biol. 2005 Jun; 25(11):4591-601. PMID: 15899862.
    Citations: 73     Fields:    Translation:HumansCells
  59. Bill HM, Knudsen B, Moores SL, Muthuswamy SK, Rao VR, Brugge JS, Miranti CK. Epidermal growth factor receptor-dependent regulation of integrin-mediated signaling and cell cycle entry in epithelial cells. Mol Cell Biol. 2004 Oct; 24(19):8586-99. PMID: 15367678.
    Citations: 41     Fields:    Translation:AnimalsCells
  60. Seton-Rogers SE, Lu Y, Hines LM, Koundinya M, LaBaer J, Muthuswamy SK, Brugge JS. Cooperation of the ErbB2 receptor and transforming growth factor beta in induction of migration and invasion in mammary epithelial cells. Proc Natl Acad Sci U S A. 2004 Feb 03; 101(5):1257-62. PMID: 14739340.
    Citations: 94     Fields:    Translation:HumansCells
  61. Reginato MJ, Mills KR, Paulus JK, Lynch DK, Sgroi DC, Debnath J, Muthuswamy SK, Brugge JS. Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikis. Nat Cell Biol. 2003 Aug; 5(8):733-40. PMID: 12844146.
    Citations: 173     Fields:    Translation:HumansAnimalsCells
  62. Debnath J, Muthuswamy SK, Brugge JS. Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods. 2003 Jul; 30(3):256-68. PMID: 12798140.
    Citations: 869     Fields:    Translation:HumansCells
  63. Debnath J, Mills KR, Collins NL, Reginato MJ, Muthuswamy SK, Brugge JS. The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini. Cell. 2002 Oct 04; 111(1):29-40. PMID: 12372298.
    Citations: 292     Fields:    Translation:HumansCells
  64. Moulder SL, Yakes FM, Muthuswamy SK, Bianco R, Simpson JF, Arteaga CL. Epidermal growth factor receptor (HER1) tyrosine kinase inhibitor ZD1839 (Iressa) inhibits HER2/neu (erbB2)-overexpressing breast cancer cells in vitro and in vivo. Cancer Res. 2001 Dec 15; 61(24):8887-95. PMID: 11751413.
    Citations: 121     Fields:    Translation:HumansAnimalsCells
  65. Muthuswamy SK, Li D, Lelievre S, Bissell MJ, Brugge JS. ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini. Nat Cell Biol. 2001 Sep; 3(9):785-92. PMID: 11533657.
    Citations: 248     Fields:    Translation:HumansAnimalsCells
  66. Muthuswamy SK, Gilman M, Brugge JS. Controlled dimerization of ErbB receptors provides evidence for differential signaling by homo- and heterodimers. Mol Cell Biol. 1999 Oct; 19(10):6845-57. PMID: 10490623.
    Citations: 109     Fields:    Translation:AnimalsCells
  67. Webster MA, Hutchinson JN, Rauh MJ, Muthuswamy SK, Anton M, Tortorice CG, Cardiff RD, Graham FL, Hassell JA, Muller WJ. Requirement for both Shc and phosphatidylinositol 3' kinase signaling pathways in polyomavirus middle T-mediated mammary tumorigenesis. Mol Cell Biol. 1998 Apr; 18(4):2344-59. PMID: 9528804.
    Citations: 83     Fields:    Translation:AnimalsCells
  68. Muller WJ, Arteaga CL, Muthuswamy SK, Siegel PM, Webster MA, Cardiff RD, Meise KS, Li F, Halter SA, Coffey RJ. Synergistic interaction of the Neu proto-oncogene product and transforming growth factor alpha in the mammary epithelium of transgenic mice. Mol Cell Biol. 1996 Oct; 16(10):5726-36. PMID: 8816486.
    Citations: 34     Fields:    Translation:AnimalsCells
  69. Muthuswamy SK, Muller WJ. Activation of Src family kinases in Neu-induced mammary tumors correlates with their association with distinct sets of tyrosine phosphorylated proteins in vivo. Oncogene. 1995 Nov 02; 11(9):1801-10. PMID: 7478608.
    Citations: 16     Fields:    Translation:AnimalsCells
  70. Muthuswamy SK, Muller WJ. Direct and specific interaction of c-Src with Neu is involved in signaling by the epidermal growth factor receptor. Oncogene. 1995 Jul 20; 11(2):271-9. PMID: 7542762.
    Citations: 22     Fields:    Translation:AnimalsCells
  71. Muthuswamy SK, Siegel PM, Dankort DL, Webster MA, Muller WJ. Mammary tumors expressing the neu proto-oncogene possess elevated c-Src tyrosine kinase activity. Mol Cell Biol. 1994 Jan; 14(1):735-43. PMID: 7903421.
    Citations: 59     Fields:    Translation:HumansAnimalsCells
  72. Muthuswamy SK, Muller WJ. Activation of the Src family of tyrosine kinases in mammary tumorigenesis. Adv Cancer Res. 1994; 64:111-23. PMID: 7879656.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  73. Guy CT, Muthuswamy SK, Cardiff RD, Soriano P, Muller WJ. Activation of the c-Src tyrosine kinase is required for the induction of mammary tumors in transgenic mice. Genes Dev. 1994 Jan; 8(1):23-32. PMID: 7507074.
    Citations: 64     Fields:    Translation:AnimalsCells
  74. Mymryk JS, Oakes JD, Muthuswamy SK, D'Amico P, Bayley ST, Lee RW. Disruption of the coordinate expression of muscle genes in a transfected BC3H1 myoblast cell line producing a low level of the adenovirus E1A transforming protein. Biochem Cell Biol. 1992 Oct-Nov; 70(10-11):1268-76. PMID: 1338413.
    Citations: 1     Fields:    Translation:AnimalsCells
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact feedbackcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Muthuswamy's Networks
Click the
Explore
buttons for more information and interactive visualizations!
Concepts (338)
Explore
_
Co-Authors (18)
Explore
_
Similar People (60)
Explore
_
Same Department 
Explore
_
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.