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profileStephen Beaven Calderwood, M.D.

TitleMorton N. Swartz, M.D. Academy Professor of Medicine (Microbiology and Molecular Genetics)
InstitutionMassachusetts General Hospital
DepartmentMedicine
AddressMassachusetts General Hospital
Infectious Disease
55 Fruit St
Boston MA 02114
Phone617/726-3811
Fax617/726-7416
vCardDownload vCard (login for email)

Collapse Mentoring 
Collapse completed student projects
A Study of Host and Pathogen Characteristics Mediating Human Immunity to V. cholerae
Summer, 06/16/08 - 08/15/08

Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
U54AI057159     (KASPER, DENNIS L.)Sep 4, 2003 - Feb 28, 2014
NIH/NIAID
New England Regional Center of Excellence in Biodefense and Emerging Infectious D
Role: Co-Principal Investigator

D43TW005572     (RYAN, EDWARD T.)Sep 29, 2000 - Feb 28, 2021
NIH/FIC
International research Training program in vaccine development and public health
Role: Co-Principal Investigator

U01AI058935     (RYAN, EDWARD T.)Sep 5, 2000 - Apr 30, 2015
NIH/NIAID
Protecutive immunity to human cholera in Bangladesh
Role: Principal Investigator

U01HD039165     (CALDERWOOD, STEPHEN B.)Sep 5, 2000 - Aug 31, 2005
NIH/NICHD
IMMUNE RESPONSES TO V. CHOLERAE INFECTION IN BANGLADESH
Role: Principal Investigator

R01AI044487     (CALDERWOOD, STEPHEN B.)Dec 15, 1998 - Nov 30, 2004
NIH/NIAID
ROLES OF TCPP AND TCPH IN GENE EXPRESSION IN V CHOLERAE
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Bhuiyan TR, Hoq MR, Nishat NS, Al Mahbuba D, Rashu R, Islam K, Hossain L, Harris JB, Ryan ET, Calderwood SB, Svennerholm AM, Qadri F. Assessing antigen specific HLA-DR+ antibody secreting cell (DR+ASC) responses in whole blood in enteric infections using an ELISPOT technique. Microbes Infect. 2017 Nov 08. PMID: 29104143.
    View in: PubMed
  2. Charles RC, Nakajima R, Liang L, Jasinskas A, Berger A, Leung DT, Kelly M, Xu P, Kovác P, Giffen SR, Harbison JD, Chowdhury F, Khan AI, Calderwood SB, Bhuiyan TR, Harris JB, Felgner PL, Qadri F, Ryan ET. Plasma and Mucosal Immunoglobulin M, Immunoglobulin A, and Immunoglobulin G Responses to the Vibrio cholerae O1 Protein Immunome in Adults With Cholera in Bangladesh. J Infect Dis. 2017 Jul 01; 216(1):125-134. PMID: 28535267.
    View in: PubMed
  3. Tucker JD, Hughes MA, Durvasula RV, Vinetz JM, McGovern VP, Schultz R, Dunavan CP, Wilson ME, Milner DA, LaRocque RC, Calderwood SB, Guerrant RL, Weller PF, Taylor TE. Measuring Success in Global Health Training: Data From 14 Years of a Postdoctoral Fellowship in Infectious Diseases and Tropical Medicine. Clin Infect Dis. 2017 Jun 15; 64(12):1768-1772. PMID: 28369324.
    View in: PubMed
  4. Mayo-Smith LM, Simon JK, Chen WH, Haney D, Lock M, Lyon CE, Calderwood SB, Kirkpatrick BD, Cohen M, Levine MM, Gurwith M, Harris JB. The Live Attenuated Cholera Vaccine CVD 103-HgR Primes Responses to the Toxin-Coregulated Pilus Antigen TcpA in Subjects Challenged with Wild-Type Vibrio cholerae. Clin Vaccine Immunol. 2017 Jan; 24(1). PMID: 27847368.
    View in: PubMed
  5. Kauffman RC, Bhuiyan TR, Nakajima R, Mayo-Smith LM, Rashu R, Hoq MR, Chowdhury F, Khan AI, Rahman A, Bhaumik SK, Harris L, O'Neal JT, Trost JF, Alam NH, Jasinskas A, Dotsey E, Kelly M, Charles RC, Xu P, Kovác P, Calderwood SB, Ryan ET, Felgner PL, Qadri F, Wrammert J, Harris JB. Single-Cell Analysis of the Plasmablast Response to Vibrio cholerae Demonstrates Expansion of Cross-Reactive Memory B Cells. MBio. 2016 Dec 20; 7(6). PMID: 27999163.
    View in: PubMed
  6. Uddin MI, Islam S, Nishat NS, Hossain M, Rafique TA, Rashu R, Hoq MR, Zhang Y, Saha A, Harris JB, Calderwood SB, Bhuiyan TR, Ryan ET, Leung DT, Qadri F. Biomarkers of Environmental Enteropathy are Positively Associated with Immune Responses to an Oral Cholera Vaccine in Bangladeshi Children. PLoS Negl Trop Dis. 2016 Nov; 10(11):e0005039. PMID: 27824883.
    View in: PubMed
  7. Park KS, Chung HJ, Khanam F, Lee H, Rashu R, Bhuiyan MT, Berger A, Harris JB, Calderwood SB, Ryan ET, Qadri F, Weissleder R, Charles RC. A magneto-DNA nanoparticle system for the rapid and sensitive diagnosis of enteric fever. Sci Rep. 2016 Sep 08; 6:32878. PMID: 27605393; PMCID: PMC5015101.
  8. Aktar A, Rahman MA, Afrin S, Faruk MO, Uddin T, Akter A, Sami MI, Yasmin T, Chowdhury F, Khan AI, Leung DT, LaRocque RC, Charles RC, Bhuiyan TR, Mandlik A, Kelly M, Kovác P, Xu P, Calderwood SB, Harris JB, Qadri F, Ryan ET. O-Specific Polysaccharide-Specific Memory B Cell Responses in Young Children, Older Children, and Adults Infected with Vibrio cholerae O1 Ogawa in Bangladesh. Clin Vaccine Immunol. 2016 05; 23(5):427-35. PMID: 27009211; PMCID: PMC4860469 [Available on 11/06/16].
  9. Chowdhury F, Mather AE, Begum YA, Asaduzzaman M, Baby N, Sharmin S, Biswas R, Uddin MI, LaRocque RC, Harris JB, Calderwood SB, Ryan ET, Clemens JD, Thomson NR, Qadri F. Vibrio cholerae Serogroup O139: Isolation from Cholera Patients and Asymptomatic Household Family Members in Bangladesh between 2013 and 2014. PLoS Negl Trop Dis. 2015 Nov; 9(11):e0004183. PMID: 26562418; PMCID: PMC4642977.
  10. Bhuiyan TR, Hoq MR, Nishat NS, Al Mahbuba D, Rashu R, Islam K, Hossain L, Dey A, Harris JB, Ryan ET, Calderwood SB, Svennerholm AM, Qadri F. Enumeration of Gut-Homing ß7-Positive, Pathogen-Specific Antibody-Secreting Cells in Whole Blood from Enterotoxigenic Escherichia coli- and Vibrio cholerae-Infected Patients, Determined Using an Enzyme-Linked Immunosorbent Spot Assay Technique. Clin Vaccine Immunol. 2015 Oct 28; 23(1):27-36. PMID: 26512047; PMCID: PMC4711085.
  11. Calderwood SB, Murray BE, Chambers HF. The 21st Century Cures Act. N Engl J Med. 2015 Oct 22; 373(17):1679. PMID: 26488713.
    View in: PubMed
  12. Chowdhury F, Kuchta A, Khan AI, Faruque AS, Calderwood SB, Ryan ET, Qadri F. The increased severity in patients presenting to hospital with diarrhea in Dhaka, Bangladesh since the emergence of the hybrid strain of Vibrio cholerae O1 is not unique to cholera patients. Int J Infect Dis. 2015 Nov; 40:9-14. PMID: 26409202; PMCID: PMC4666742 [Available on 11/01/16].
  13. Khan AI, Chowdhury F, Leung DT, Larocque RC, Harris JB, Ryan ET, Calderwood SB, Qadri F. Cholera in pregnancy: Clinical and immunological aspects. Int J Infect Dis. 2015 Oct; 39:20-4. PMID: 26283553; PMCID: PMC4830121 [Available on 10/01/16].
  14. Dalia AB, Seed KD, Calderwood SB, Camilli A. A globally distributed mobile genetic element inhibits natural transformation of Vibrio cholerae. Proc Natl Acad Sci U S A. 2015 Aug 18; 112(33):10485-90. PMID: 26240317; PMCID: PMC4547284.
  15. Sayeed MA, Bufano MK, Xu P, Eckhoff G, Charles RC, Alam MM, Sultana T, Rashu MR, Berger A, Gonzalez-Escobedo G, Mandlik A, Bhuiyan TR, Leung DT, LaRocque RC, Harris JB, Calderwood SB, Qadri F, Vann WF, Kovác P, Ryan ET. A Cholera Conjugate Vaccine Containing O-specific Polysaccharide (OSP) of V. cholerae O1 Inaba and Recombinant Fragment of Tetanus Toxin Heavy Chain (OSP:rTTHc) Induces Serum, Memory and Lamina Proprial Responses against OSP and Is Protective in Mice. PLoS Negl Trop Dis. 2015; 9(7):e0003881. PMID: 26154421; PMCID: PMC4495926.
  16. Falkard B, Uddin T, Rahman MA, Franke MF, Aktar A, Uddin MI, Bhuiyan TR, Leung DT, Charles RC, Larocque RC, Harris JB, Calderwood SB, Qadri F, Ryan ET. Plasma Leptin Levels in Children Hospitalized with Cholera in Bangladesh. Am J Trop Med Hyg. 2015 Aug; 93(2):244-9. PMID: 26055740; PMCID: PMC4530742.
  17. David LA, Weil A, Ryan ET, Calderwood SB, Harris JB, Chowdhury F, Begum Y, Qadri F, LaRocque RC, Turnbaugh PJ. Gut microbial succession follows acute secretory diarrhea in humans. MBio. 2015 May 19; 6(3):e00381-15. PMID: 25991682; PMCID: PMC4442136.
  18. Khanam F, Sayeed MA, Choudhury FK, Sheikh A, Ahmed D, Goswami D, Hossain ML, Brooks A, Calderwood SB, Charles RC, Cravioto A, Ryan ET, Qadri F. Typhoid fever in young children in Bangladesh: clinical findings, antibiotic susceptibility pattern and immune responses. PLoS Negl Trop Dis. 2015 Apr; 9(4):e0003619. PMID: 25849611; PMCID: PMC4388457.
  19. Kudva IT, Krastins B, Torres AG, Griffin RW, Sheng H, Sarracino DA, Hovde CJ, Calderwood SB, John M. The Escherichia coli O157:H7 cattle immunoproteome includes outer membrane protein A (OmpA), a modulator of adherence to bovine rectoanal junction squamous epithelial (RSE) cells. Proteomics. 2015 Jun; 15(11):1829-42. PMID: 25643951; PMCID: PMC4456246.
  20. Calderwood SB. IDSA Response to Factors Contributing to the Decline of Medical Residents Choosing the Field of Infectious Diseases. Clin Infect Dis. 2015 Jun 01; 60(11):1724. PMID: 25713184.
    View in: PubMed
  21. Ellis CN, LaRocque RC, Uddin T, Krastins B, Mayo-Smith LM, Sarracino D, Karlsson EK, Rahman A, Shirin T, Bhuiyan TR, Chowdhury F, Khan AI, Ryan ET, Calderwood SB, Qadri F, Harris JB. Comparative proteomic analysis reveals activation of mucosal innate immune signaling pathways during cholera. Infect Immun. 2015 Mar; 83(3):1089-103. PMID: 25561705; PMCID: PMC4333457.
  22. Sugimoto JD, Koepke AA, Kenah EE, Halloran ME, Chowdhury F, Khan AI, LaRocque RC, Yang Y, Ryan ET, Qadri F, Calderwood SB, Harris JB, Longini IM. Household Transmission of Vibrio cholerae in Bangladesh. PLoS Negl Trop Dis. 2014 Nov; 8(11):e3314. PMID: 25411971; PMCID: PMC4238997.
  23. Rychert J, Creely D, Mayo-Smith LM, Calderwood SB, Ivers LC, Ryan ET, Boncy J, Qadri F, Ahmed D, Ferraro MJ, Harris JB. Evaluation of matrix-assisted laser desorption ionization-time of flight mass spectrometry for identification of Vibrio cholerae. J Clin Microbiol. 2015 Jan; 53(1):329-31. PMID: 25392355; PMCID: PMC4290949.
  24. Leung DT, Bhuiyan TR, Nishat NS, Hoq MR, Aktar A, Rahman MA, Uddin T, Khan AI, Chowdhury F, Charles RC, Harris JB, Calderwood SB, Qadri F, Ryan ET. Circulating mucosal associated invariant T cells are activated in Vibrio cholerae O1 infection and associated with lipopolysaccharide antibody responses. PLoS Negl Trop Dis. 2014 Aug; 8(8):e3076. PMID: 25144724; PMCID: PMC4140671.
  25. Weil AA, Begum Y, Chowdhury F, Khan AI, Leung DT, LaRocque RC, Charles RC, Ryan ET, Calderwood SB, Qadri F, Harris JB. Bacterial shedding in household contacts of cholera patients in Dhaka, Bangladesh. Am J Trop Med Hyg. 2014 Oct; 91(4):738-42. PMID: 25114012; PMCID: PMC4183396.
  26. Calderwood SB, Hooper DC. In memoriam: Morton N. Swartz. J Infect Dis. 2015 Jan 01; 211(1):1-3. PMID: 25030059.
    View in: PubMed
  27. Charles RC, Hilaire IJ, Mayo-Smith LM, Teng JE, Jerome JG, Franke MF, Saha A, Yu Y, Kovác P, Calderwood SB, Ryan ET, LaRocque RC, Almazor CP, Qadri F, Ivers LC, Harris JB. Immunogenicity of a killed bivalent (O1 and O139) whole cell oral cholera vaccine, Shanchol, in Haiti. PLoS Negl Trop Dis. 2014 May; 8(5):e2828. PMID: 24786645; PMCID: PMC4006712.
  28. Alam MM, Aktar A, Afrin S, Rahman MA, Aktar S, Uddin T, Rahman MA, Al Mahbuba D, Chowdhury F, Khan AI, Bhuiyan TR, Begum YA, Ryan ET, Calderwood SB, Svennerholm AM, Qadri F. Antigen-specific memory B-cell responses to enterotoxigenic Escherichia coli infection in Bangladeshi adults. PLoS Negl Trop Dis. 2014 Apr; 8(4):e2822. PMID: 24762744; PMCID: PMC3998937.
  29. Uddin T, Aktar A, Xu P, Johnson RA, Rahman MA, Leung DT, Afrin S, Akter A, Alam MM, Rahman A, Chowdhury F, Khan AI, Bhuiyan TR, Bufano MK, Rashu R, Yu Y, Wu-Freeman Y, Harris JB, LaRocque RC, Charles RC, Kovác P, Calderwood SB, Ryan ET, Qadri F. Immune responses to O-specific polysaccharide and lipopolysaccharide of Vibrio cholerae O1 Ogawa in adult Bangladeshi recipients of an oral killed cholera vaccine and comparison to responses in patients with cholera. Am J Trop Med Hyg. 2014 May; 90(5):873-81. PMID: 24686738; PMCID: PMC4015581.
  30. Bhuiyan S, Sayeed A, Khanam F, Leung DT, Rahman Bhuiyan T, Sheikh A, Salma U, LaRocque RC, Harris JB, Pacek M, Calderwood SB, LaBaer J, Ryan ET, Qadri F, Charles RC. Cellular and cytokine responses to Salmonella enterica serotype Typhi proteins in patients with typhoid fever in Bangladesh. Am J Trop Med Hyg. 2014 Jun; 90(6):1024-30. PMID: 24615129; PMCID: PMC4047724.
  31. Alam MM, Bufano MK, Xu P, Kalsy A, Yu Y, Freeman YW, Sultana T, Rashu MR, Desai I, Eckhoff G, Leung DT, Charles RC, LaRocque RC, Harris JB, Clements JD, Calderwood SB, Qadri F, Vann WF, Kovác P, Ryan ET. Evaluation in mice of a conjugate vaccine for cholera made from Vibrio cholerae O1 (Ogawa) O-specific polysaccharide. PLoS Negl Trop Dis. 2014 Feb; 8(2):e2683. PMID: 24516685; PMCID: PMC3916310.
  32. Charles RC, Liang L, Khanam F, Sayeed MA, Hung C, Leung DT, Baker S, Ludwig A, Harris JB, Larocque RC, Calderwood SB, Qadri F, Felgner PL, Ryan ET. Immunoproteomic analysis of antibody in lymphocyte supernatant in patients with typhoid fever in Bangladesh. Clin Vaccine Immunol. 2014 Mar; 21(3):280-5. PMID: 24371257; PMCID: PMC3957676.
  33. Kudva IT, Smole S, Griffin RW, Garren J, Kalia N, Murray M, John M, Timperi R, Calderwood SB. Polymorphic Amplified Typing Sequences (PATS) Strain Typing System Accurately Discriminates a Set of Temporally and Spatially Disparate Escherichia coli O157 Isolates Associated with Human Infection. Open Microbiol J. 2013; 7:123-9. PMID: 24278089; PMCID: PMC3837366.
  34. Rahman A, Rashu R, Bhuiyan TR, Chowdhury F, Khan AI, Islam K, LaRocque RC, Ryan ET, Wrammert J, Calderwood SB, Qadri F, Harris JB. Antibody-secreting cell responses after Vibrio cholerae O1 infection and oral cholera vaccination in adults in Bangladesh. Clin Vaccine Immunol. 2013 Oct; 20(10):1592-8. PMID: 23945156; PMCID: PMC3807192.
  35. Alam MM, Leung DT, Akhtar M, Nazim M, Akter S, Uddin T, Khanam F, Mahbuba DA, Ahmad SM, Bhuiyan TR, Calderwood SB, Ryan ET, Qadri F. Antibody avidity in humoral immune responses in Bangladeshi children and adults following administration of an oral killed cholera vaccine. Clin Vaccine Immunol. 2013 Oct; 20(10):1541-8. PMID: 23925888; PMCID: PMC3807205.
  36. Charles RC, Sultana T, Alam MM, Yu Y, Wu-Freeman Y, Bufano MK, Rollins SM, Tsai L, Harris JB, LaRocque RC, Leung DT, Brooks WA, Nga TV, Dongol S, Basnyat B, Calderwood SB, Farrar J, Khanam F, Gunn JS, Qadri F, Baker S, Ryan ET. Identification of immunogenic Salmonella enterica serotype Typhi antigens expressed in chronic biliary carriers of S. Typhi in Kathmandu, Nepal. PLoS Negl Trop Dis. 2013; 7(8):e2335. PMID: 23936575; PMCID: PMC3731212.
  37. Khanam F, Sheikh A, Sayeed MA, Bhuiyan MS, Choudhury FK, Salma U, Pervin S, Sultana T, Ahmed D, Goswami D, Hossain ML, Mamun KZ, Charles RC, Brooks WA, Calderwood SB, Cravioto A, Ryan ET, Qadri F. Evaluation of a typhoid/paratyphoid diagnostic assay (TPTest) detecting anti-Salmonella IgA in secretions of peripheral blood lymphocytes in patients in Dhaka, Bangladesh. PLoS Negl Trop Dis. 2013; 7(7):e2316. PMID: 23951368; PMCID: PMC3708850.
  38. Karlsson EK, Harris JB, Tabrizi S, Rahman A, Shlyakhter I, Patterson N, O'Dushlaine C, Schaffner SF, Gupta S, Chowdhury F, Sheikh A, Shin OS, Ellis C, Becker CE, Stuart LM, Calderwood SB, Ryan ET, Qadri F, Sabeti PC, Larocque RC. Natural selection in a bangladeshi population from the cholera-endemic ganges river delta. Sci Transl Med. 2013 Jul 03; 5(192):192ra86. PMID: 23825302; PMCID: PMC4367964.
  39. Greka A, Dekker JP, Calderwood SB. Case 4-2013: A man with acute flank pain. N Engl J Med. 2013 Jun 06; 368(23):2237. PMID: 23738559.
    View in: PubMed
  40. Leung DT, Uddin T, Xu P, Aktar A, Johnson RA, Rahman MA, Alam MM, Bufano MK, Eckhoff G, Wu-Freeman Y, Yu Y, Sultana T, Khanam F, Saha A, Chowdhury F, Khan AI, Charles RC, Larocque RC, Harris JB, Calderwood SB, Kovác P, Qadri F, Ryan ET. Immune responses to the O-specific polysaccharide antigen in children who received a killed oral cholera vaccine compared to responses following natural cholera infection in Bangladesh. Clin Vaccine Immunol. 2013 Jun; 20(6):780-8. PMID: 23515016; PMCID: PMC3675980.
  41. Alam MM, Tsai LL, Rollins SM, Sheikh A, Khanam F, Bufano MK, Yu Y, Wu-Freeman Y, Kalsy A, Sultana T, Sayeed MA, Jahan N, LaRocque RC, Harris JB, Leung DT, Brooks WA, Calderwood SB, Charles RC, Qadri F, Ryan ET. Identification of in vivo-induced bacterial proteins during human infection with Salmonella enterica serotype Paratyphi A. Clin Vaccine Immunol. 2013 May; 20(5):712-9. PMID: 23486419; PMCID: PMC3647755.
  42. Seed KD, Lazinski DW, Calderwood SB, Camilli A. A bacteriophage encodes its own CRISPR/Cas adaptive response to evade host innate immunity. Nature. 2013 Feb 28; 494(7438):489-91. PMID: 23446421; PMCID: PMC3587790.
  43. Alam MM, Arifuzzaman M, Ahmad SM, Hosen MI, Rahman MA, Rashu R, Sheikh A, Ryan ET, Calderwood SB, Qadri F. Study of avidity of antigen-specific antibody as a means of understanding development of long-term immunological memory after Vibrio cholerae O1 infection. Clin Vaccine Immunol. 2013 Jan; 20(1):17-23. PMID: 23114701; PMCID: PMC3535784.
  44. Johnson RA, Uddin T, Aktar A, Mohasin M, Alam MM, Chowdhury F, Harris JB, LaRocque RC, Bufano MK, Yu Y, Wu-Freeman Y, Leung DT, Sarracino D, Krastins B, Charles RC, Xu P, Kovác P, Calderwood SB, Qadri F, Ryan ET. Comparison of immune responses to the O-specific polysaccharide and lipopolysaccharide of Vibrio cholerae O1 in Bangladeshi adult patients with cholera. Clin Vaccine Immunol. 2012 Nov; 19(11):1712-21. PMID: 22993410; PMCID: PMC3491541.
  45. Seed KD, Faruque SM, Mekalanos JJ, Calderwood SB, Qadri F, Camilli A. Phase variable O antigen biosynthetic genes control expression of the major protective antigen and bacteriophage receptor in Vibrio cholerae O1. PLoS Pathog. 2012 Sep; 8(9):e1002917. PMID: 23028317; PMCID: PMC3441752.
  46. Sealfon R, Gire S, Ellis C, Calderwood S, Qadri F, Hensley L, Kellis M, Ryan ET, LaRocque RC, Harris JB, Sabeti PC. High depth, whole-genome sequencing of cholera isolates from Haiti and the Dominican Republic. BMC Genomics. 2012 Sep 11; 13:468. PMID: 22963323; PMCID: PMC3473251.
  47. Weil AA, Chowdhury F, Khan AI, Leung DT, Uddin T, Begum YA, Saha NC, Charles RC, Larocque RC, Harris JB, Ryan ET, Qadri F, Calderwood SB. Frequency of reexposure to Vibrio cholerae O1 evaluated by subsequent vibriocidal titer rise after an episode of severe cholera in a highly endemic area in Bangladesh. Am J Trop Med Hyg. 2012 Nov; 87(5):921-6. PMID: 22964723; PMCID: PMC3516269.
  48. Kudva IT, Davis MA, Griffin RW, Garren J, Murray M, John M, Hovde CJ, Calderwood SB. Polymorphic Amplified Typing Sequences and Pulsed-Field Gel Electrophoresis Yield Comparable Results in the Strain Typing of a Diverse Set of Bovine Escherichia coli O157:H7 Isolates. Int J Microbiol. 2012; 2012:140105. PMID: 23049559; PMCID: PMC3461292.
  49. Harris JB, LaRocque RC, Qadri F, Ryan ET, Calderwood SB. Cholera. Lancet. 2012 Jun 30; 379(9835):2466-76. PMID: 22748592; PMCID: PMC3761070.
  50. Arifuzzaman M, Rashu R, Leung DT, Hosen MI, Bhuiyan TR, Bhuiyan MS, Rahman MA, Khanam F, Saha A, Charles RC, LaRocque RC, Weil AA, Clements JD, Holmes RK, Calderwood SB, Harris JB, Ryan ET, Qadri F. Antigen-specific memory T cell responses after vaccination with an oral killed cholera vaccine in Bangladeshi children and comparison to responses in patients with naturally acquired cholera. Clin Vaccine Immunol. 2012 Aug; 19(8):1304-11. PMID: 22739692; PMCID: PMC3416086.
  51. Kudva IT, Griffin RW, Krastins B, Sarracino DA, Calderwood SB, John M. Proteins other than the locus of enterocyte effacement-encoded proteins contribute to Escherichia coli O157:H7 adherence to bovine rectoanal junction stratified squamous epithelial cells. BMC Microbiol. 2012 Jun 12; 12:103. PMID: 22691138; PMCID: PMC3420319.
  52. Patel SM, Rahman MA, Mohasin M, Riyadh MA, Leung DT, Alam MM, Chowdhury F, Khan AI, Weil AA, Aktar A, Nazim M, LaRocque RC, Ryan ET, Calderwood SB, Qadri F, Harris JB. Memory B cell responses to Vibrio cholerae O1 lipopolysaccharide are associated with protection against infection from household contacts of patients with cholera in Bangladesh. Clin Vaccine Immunol. 2012 Jun; 19(6):842-8. PMID: 22518009; PMCID: PMC3370438.
  53. Leung DT, Chowdhury F, Calderwood SB, Qadri F, Ryan ET. Immune responses to cholera in children. Expert Rev Anti Infect Ther. 2012 Apr; 10(4):435-44. PMID: 22512753; PMCID: PMC3378723.
  54. Leung DT, Rahman MA, Mohasin M, Patel SM, Aktar A, Khanam F, Uddin T, Riyadh MA, Saha A, Alam MM, Chowdhury F, Khan AI, Charles R, LaRocque R, Harris JB, Calderwood SB, Qadri F, Ryan ET. Memory B cell and other immune responses in children receiving two doses of an oral killed cholera vaccine compared to responses following natural cholera infection in Bangladesh. Clin Vaccine Immunol. 2012 May; 19(5):690-8. PMID: 22441386; PMCID: PMC3346319.
  55. Tarique AA, Kalsy A, Arifuzzaman M, Rollins SM, Charles RC, Leung DT, Harris JB, Larocque RC, Sheikh A, Bhuiyan MS, Saksena R, Clements JD, Calderwood SB, Qadri F, Kovác P, Ryan ET. Transcutaneous immunization with a Vibrio cholerae O1 Ogawa synthetic hexasaccharide conjugate following oral whole-cell cholera vaccination boosts vibriocidal responses and induces protective immunity in mice. Clin Vaccine Immunol. 2012 Apr; 19(4):594-602. PMID: 22357651; PMCID: PMC3318280.
  56. Borad AJ, Allison GM, Wang D, Ahmed S, Karim MM, Kane AV, Moy J, Hibberd PL, Ajjampur SS, Kang G, Calderwood SB, Ryan ET, Naumova E, Khan WA, Ward HD. Systemic antibody responses to the immunodominant p23 antigen and p23 polymorphisms in children with cryptosporidiosis in Bangladesh. Am J Trop Med Hyg. 2012 Feb; 86(2):214-22. PMID: 22302851; PMCID: PMC3269270.
  57. Arifuzzaman M, Ahmed T, Rahman MA, Chowdhury F, Rashu R, Khan AI, LaRocque RC, Harris JB, Bhuiyan TR, Ryan ET, Calderwood SB, Qadri F. Individuals with Le(a+b-) blood group have increased susceptibility to symptomatic vibrio cholerae O1 infection. PLoS Negl Trop Dis. 2011 Dec; 5(12):e1413. PMID: 22216364; PMCID: PMC3246451.
  58. Sheikh A, Charles RC, Sharmeen N, Rollins SM, Harris JB, Bhuiyan MS, Arifuzzaman M, Khanam F, Bukka A, Kalsy A, Porwollik S, Leung DT, Brooks WA, LaRocque RC, Hohmann EL, Cravioto A, Logvinenko T, Calderwood SB, McClelland M, Graham JE, Qadri F, Ryan ET. In vivo expression of Salmonella enterica serotype Typhi genes in the blood of patients with typhoid fever in Bangladesh. PLoS Negl Trop Dis. 2011 Dec; 5(12):e1419. PMID: 22180799; PMCID: PMC3236720.
  59. Bishop AL, Tarique AA, Patimalla B, Calderwood SB, Qadri F, Camilli A. Immunization of mice with vibrio cholerae outer-membrane vesicles protects against hyperinfectious challenge and blocks transmission. J Infect Dis. 2012 Feb 01; 205(3):412-21. PMID: 22147790; PMCID: PMC3256948.
  60. Xu P, Alam MM, Kalsy A, Charles RC, Calderwood SB, Qadri F, Ryan ET, Kovác P. Simple, direct conjugation of bacterial O-SP-core antigens to proteins: development of cholera conjugate vaccines. Bioconjug Chem. 2011 Oct 19; 22(10):2179-85. PMID: 21899371; PMCID: PMC3197769.
  61. Shin OS, Uddin T, Citorik R, Wang JP, Della Pelle P, Kradin RL, Bingle CD, Bingle L, Camilli A, Bhuiyan TR, Shirin T, Ryan ET, Calderwood SB, Finberg RW, Qadri F, Larocque RC, Harris JB. LPLUNC1 modulates innate immune responses to Vibrio cholerae. J Infect Dis. 2011 Nov; 204(9):1349-57. PMID: 21900486; PMCID: PMC3182310.
  62. Allison GM, Rogers KA, Borad A, Ahmed S, Karim MM, Kane AV, Hibberd PL, Naumova EN, Calderwood SB, Ryan ET, Khan WA, Ward HD. Antibody responses to the immunodominant Cryptosporidium gp15 antigen and gp15 polymorphisms in a case-control study of cryptosporidiosis in children in Bangladesh. Am J Trop Med Hyg. 2011 Jul; 85(1):97-104. PMID: 21734132; PMCID: PMC3122351.
  63. Leung DT, Rahman MA, Mohasin M, Riyadh MA, Patel SM, Alam MM, Chowdhury F, Khan AI, Kalivoda EJ, Aktar A, Bhuiyan MS, LaRocque RC, Harris JB, Calderwood SB, Qadri F, Ryan ET. Comparison of memory B cell, antibody-secreting cell, and plasma antibody responses in young children, older children, and adults with infection caused by Vibrio cholerae O1 El Tor Ogawa in Bangladesh. Clin Vaccine Immunol. 2011 Aug; 18(8):1317-25. PMID: 21697337; PMCID: PMC3147357.
  64. Kuchta A, Rahman T, Sennott EL, Bhuyian TR, Uddin T, Rashu R, Chowdhury F, Kahn AI, Arifuzzaman M, Weil AA, Podolsky M, LaRocque RC, Ryan ET, Calderwood SB, Qadri F, Harris JB. Vibrio cholerae O1 infection induces proinflammatory CD4+ T-cell responses in blood and intestinal mucosa of infected humans. Clin Vaccine Immunol. 2011 Aug; 18(8):1371-7. PMID: 21697339; PMCID: PMC3147337.
  65. Sheikh A, Khanam F, Sayeed MA, Rahman T, Pacek M, Hu Y, Rollins A, Bhuiyan MS, Rollins S, Kalsy A, Arifuzzaman M, Leung DT, Sarracino DA, Krastins B, Charles RC, Larocque RC, Cravioto A, Calderwood SB, Brooks WA, Harris JB, Labaer J, Qadri F, Ryan ET. Interferon-? and proliferation responses to Salmonella enterica Serotype Typhi proteins in patients with S. Typhi Bacteremia in Dhaka, Bangladesh. PLoS Negl Trop Dis. 2011 Jun; 5(6):e1193. PMID: 21666798; PMCID: PMC3110156.
  66. Farmer P, Almazor CP, Bahnsen ET, Barry D, Bazile J, Bloom BR, Bose N, Brewer T, Calderwood SB, Clemens JD, Cravioto A, Eustache E, Jérôme G, Gupta N, Harris JB, Hiatt HH, Holstein C, Hotez PJ, Ivers LC, Kerry VB, Koenig SP, Larocque RC, Léandre F, Lambert W, Lyon E, Mekalanos JJ, Mukherjee JS, Oswald C, Pape JW, Gretchko Prosper A, Rabinovich R, Raymonville M, Réjouit JR, Ronan LJ, Rosenberg ML, Ryan ET, Sachs JD, Sack DA, Surena C, Suri AA, Ternier R, Waldor MK, Walton D, Weigel JL. Meeting cholera's challenge to Haiti and the world: a joint statement on cholera prevention and care. PLoS Negl Trop Dis. 2011; 5(5):e1145. PMID: 21655350; PMCID: PMC3104956.
  67. Hira KG, Mackay MR, Hempstead AD, Ahmed S, Karim MM, O'Connor RM, Hibberd PL, Calderwood SB, Ryan ET, Khan WA, Ward HD. Genetic diversity of Cryptosporidium spp. from Bangladeshi children. J Clin Microbiol. 2011 Jun; 49(6):2307-10. PMID: 21471344; PMCID: PMC3122776.
  68. Alam MM, Riyadh MA, Fatema K, Rahman MA, Akhtar N, Ahmed T, Chowdhury MI, Chowdhury F, Calderwood SB, Harris JB, Ryan ET, Qadri F. Antigen-specific memory B-cell responses in Bangladeshi adults after one- or two-dose oral killed cholera vaccination and comparison with responses in patients with naturally acquired cholera. Clin Vaccine Immunol. 2011 May; 18(5):844-50. PMID: 21346055; PMCID: PMC3122537.
  69. Seed KD, Bodi KL, Kropinski AM, Ackermann HW, Calderwood SB, Qadri F, Camilli A. Evidence of a dominant lineage of Vibrio cholerae-specific lytic bacteriophages shed by cholera patients over a 10-year period in Dhaka, Bangladesh. MBio. 2011; 2(1):e00334-10. PMID: 21304168; PMCID: PMC3037004.
  70. Uddin T, Harris JB, Bhuiyan TR, Shirin T, Uddin MI, Khan AI, Chowdhury F, LaRocque RC, Alam NH, Ryan ET, Calderwood SB, Qadri F. Mucosal immunologic responses in cholera patients in Bangladesh. Clin Vaccine Immunol. 2011 Mar; 18(3):506-12. PMID: 21248157; PMCID: PMC3067383.
  71. Chin CS, Sorenson J, Harris JB, Robins WP, Charles RC, Jean-Charles RR, Bullard J, Webster DR, Kasarskis A, Peluso P, Paxinos EE, Yamaichi Y, Calderwood SB, Mekalanos JJ, Schadt EE, Waldor MK. The origin of the Haitian cholera outbreak strain. N Engl J Med. 2011 Jan 06; 364(1):33-42. PMID: 21142692; PMCID: PMC3030187.
  72. Sheikh A, Charles RC, Rollins SM, Harris JB, Bhuiyan MS, Khanam F, Bukka A, Kalsy A, Porwollik S, Brooks WA, LaRocque RC, Hohmann EL, Cravioto A, Logvinenko T, Calderwood SB, McClelland M, Graham JE, Qadri F, Ryan ET. Analysis of Salmonella enterica serotype paratyphi A gene expression in the blood of bacteremic patients in Bangladesh. PLoS Negl Trop Dis. 2010 Dec 07; 4(12):e908. PMID: 21151879; PMCID: PMC2998432.
  73. Kanjilal S, Citorik R, LaRocque RC, Ramoni MF, Calderwood SB. A systems biology approach to modeling vibrio cholerae gene expression under virulence-inducing conditions. J Bacteriol. 2010 Sep; 192(17):4300-10. PMID: 20601467; PMCID: PMC2937380.
  74. Kendall EA, Chowdhury F, Begum Y, Khan AI, Li S, Thierer JH, Bailey J, Kreisel K, Tacket CO, LaRocque RC, Harris JB, Ryan ET, Qadri F, Calderwood SB, Stine OC. Relatedness of Vibrio cholerae O1/O139 isolates from patients and their household contacts, determined by multilocus variable-number tandem-repeat analysis. J Bacteriol. 2010 Sep; 192(17):4367-76. PMID: 20585059; PMCID: PMC2937383.
  75. Charles RC, Sheikh A, Krastins B, Harris JB, Bhuiyan MS, LaRocque RC, Logvinenko T, Sarracino DA, Kudva IT, Eisenstein J, Podolsky MJ, Kalsy A, Brooks WA, Ludwig A, John M, Calderwood SB, Qadri F, Ryan ET. Characterization of anti-Salmonella enterica serotype Typhi antibody responses in bacteremic Bangladeshi patients by an immunoaffinity proteomics-based technology. Clin Vaccine Immunol. 2010 Aug; 17(8):1188-95. PMID: 20573880; PMCID: PMC2916242.
  76. Chowdhury F, Begum YA, Alam MM, Khan AI, Ahmed T, Bhuiyan MS, Harris JB, LaRocque RC, Faruque AS, Endtz H, Ryan ET, Cravioto A, Svennerholm AM, Calderwood SB, Qadri F. Concomitant enterotoxigenic Escherichia coli infection induces increased immune responses to Vibrio cholerae O1 antigens in patients with cholera in Bangladesh. Infect Immun. 2010 May; 78(5):2117-24. PMID: 20176796; PMCID: PMC2863502.
  77. Kamruzzaman M, Udden SM, Cameron DE, Calderwood SB, Nair GB, Mekalanos JJ, Faruque SM. Quorum-regulated biofilms enhance the development of conditionally viable, environmental Vibrio cholerae. Proc Natl Acad Sci U S A. 2010 Jan 26; 107(4):1588-93. PMID: 20080633; PMCID: PMC2824409.
  78. Khan AI, Chowdhury F, Harris JB, Larocque RC, Faruque AS, Ryan ET, Calderwood SB, Qadri F. Comparison of clinical features and immunological parameters of patients with dehydrating diarrhoea infected with Inaba or Ogawa serotypes of Vibrio cholerae O1. Scand J Infect Dis. 2010; 42(1):48-56. PMID: 19883159; PMCID: PMC3786431.
  79. Rahman KM, Duggal P, Harris JB, Saha SK, Streatfield PK, Ryan ET, Calderwood SB, Qadri F, Yunus M, LaRocque RC. Familial aggregation of Vibrio cholerae-associated infection in Matlab, Bangladesh. J Health Popul Nutr. 2009 Dec; 27(6):733-8. PMID: 20099756; PMCID: PMC2928116.
  80. Kim HB, Wang M, Ahmed S, Park CH, LaRocque RC, Faruque AS, Salam MA, Khan WA, Qadri F, Calderwood SB, Jacoby GA, Hooper DC. Transferable quinolone resistance in Vibrio cholerae. Antimicrob Agents Chemother. 2010 Feb; 54(2):799-803. PMID: 19949057; PMCID: PMC2812163.
  81. Weil AA, Khan AI, Chowdhury F, Larocque RC, Faruque AS, Ryan ET, Calderwood SB, Qadri F, Harris JB. Clinical outcomes in household contacts of patients with cholera in Bangladesh. Clin Infect Dis. 2009 Nov 15; 49(10):1473-9. PMID: 19842974; PMCID: PMC2783773.
  82. Kendall EA, Tarique AA, Hossain A, Alam MM, Arifuzzaman M, Akhtar N, Chowdhury F, Khan AI, Larocque RC, Harris JB, Ryan ET, Qadri F, Calderwood SB. Development of immunoglobulin M memory to both a T-cell-independent and a T-cell-dependent antigen following infection with Vibrio cholerae O1 in Bangladesh. Infect Immun. 2010 Jan; 78(1):253-9. PMID: 19858296; PMCID: PMC2798198.
  83. Nelson EJ, Harris JB, Morris JG, Calderwood SB, Camilli A. Cholera transmission: the host, pathogen and bacteriophage dynamic. Nat Rev Microbiol. 2009 Oct; 7(10):693-702. PMID: 19756008; PMCID: PMC3842031.
  84. Charles RC, Harris JB, Chase MR, Lebrun LM, Sheikh A, LaRocque RC, Logvinenko T, Rollins SM, Tarique A, Hohmann EL, Rosenberg I, Krastins B, Sarracino DA, Qadri F, Calderwood SB, Ryan ET. Comparative proteomic analysis of the PhoP regulon in Salmonella enterica serovar Typhi versus Typhimurium. PLoS One. 2009 Sep 10; 4(9):e6994. PMID: 19746165; PMCID: PMC2736619.
  85. Sheikh A, Bhuiyan MS, Khanam F, Chowdhury F, Saha A, Ahmed D, Jamil KM, LaRocque RC, Harris JB, Ahmad MM, Charles R, Brooks WA, Calderwood SB, Cravioto A, Ryan ET, Qadri F. Salmonella enterica serovar Typhi-specific immunoglobulin A antibody responses in plasma and antibody in lymphocyte supernatant specimens in Bangladeshi patients with suspected typhoid fever. Clin Vaccine Immunol. 2009 Nov; 16(11):1587-94. PMID: 19741090; PMCID: PMC2772369.
  86. Weil AA, Arifuzzaman M, Bhuiyan TR, LaRocque RC, Harris AM, Kendall EA, Hossain A, Tarique AA, Sheikh A, Chowdhury F, Khan AI, Murshed F, Parker KC, Banerjee KK, Ryan ET, Harris JB, Qadri F, Calderwood SB. Memory T-cell responses to Vibrio cholerae O1 infection. Infect Immun. 2009 Nov; 77(11):5090-6. PMID: 19703973; PMCID: PMC2772559.
  87. Rollenhagen JE, Kalsy A, Saksena R, Sheikh A, Alam MM, Qadri F, Calderwood SB, Kovác P, Ryan ET. Transcutaneous immunization with a synthetic hexasaccharide-protein conjugate induces anti-Vibrio cholerae lipopolysaccharide responses in mice. Vaccine. 2009 Aug 06; 27(36):4917-22. PMID: 19563890; PMCID: PMC2761657.
  88. Harris AM, Bhuiyan MS, Chowdhury F, Khan AI, Hossain A, Kendall EA, Rahman A, LaRocque RC, Wrammert J, Ryan ET, Qadri F, Calderwood SB, Harris JB. Antigen-specific memory B-cell responses to Vibrio cholerae O1 infection in Bangladesh. Infect Immun. 2009 Sep; 77(9):3850-6. PMID: 19528207; PMCID: PMC2738048.
  89. Nelson EJ, Tanudra A, Chowdhury A, Kane AV, Qadri F, Calderwood SB, Coburn J, Camilli A. High prevalence of spirochetosis in cholera patients, Bangladesh. Emerg Infect Dis. 2009 Apr; 15(4):571-3. PMID: 19331734; PMCID: PMC2671413.
  90. Harris JB, Podolsky MJ, Bhuiyan TR, Chowdhury F, Khan AI, Larocque RC, Logvinenko T, Kendall J, Faruque AS, Nagler CR, Ryan ET, Qadri F, Calderwood SB. Immunologic responses to Vibrio cholerae in patients co-infected with intestinal parasites in Bangladesh. PLoS Negl Trop Dis. 2009; 3(3):e403. PMID: 19333369; PMCID: PMC2657204.
  91. Means TK, Mylonakis E, Tampakakis E, Colvin RA, Seung E, Puckett L, Tai MF, Stewart CR, Pukkila-Worley R, Hickman SE, Moore KJ, Calderwood SB, Hacohen N, Luster AD, El Khoury J. Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36. J Exp Med. 2009 Mar 16; 206(3):637-53. PMID: 19237602; PMCID: PMC2699123.
  92. Bhuiyan TR, Lundin SB, Khan AI, Lundgren A, Harris JB, Calderwood SB, Qadri F. Cholera caused by Vibrio cholerae O1 induces T-cell responses in the circulation. Infect Immun. 2009 May; 77(5):1888-93. PMID: 19237532; PMCID: PMC2681774.
  93. Larocque RC, Sabeti P, Duggal P, Chowdhury F, Khan AI, Lebrun LM, Harris JB, Ryan ET, Qadri F, Calderwood SB. A variant in long palate, lung and nasal epithelium clone 1 is associated with cholera in a Bangladeshi population. Genes Immun. 2009 Apr; 10(3):267-72. PMID: 19212328; PMCID: PMC2672110.
  94. Harris AM, Chowdhury F, Begum YA, Khan AI, Faruque AS, Svennerholm AM, Harris JB, Ryan ET, Cravioto A, Calderwood SB, Qadri F. Shifting prevalence of major diarrheal pathogens in patients seeking hospital care during floods in 1998, 2004, and 2007 in Dhaka, Bangladesh. Am J Trop Med Hyg. 2008 Nov; 79(5):708-14. PMID: 18981509; PMCID: PMC2749297.
  95. Chowdhury F, Khan AI, Harris JB, LaRocque RC, Chowdhury MI, Ryan ET, Faruque AS, Calderwood SB, Qadri F. A comparison of clinical and immunologic features in children and older patients hospitalized with severe cholera in Bangladesh. Pediatr Infect Dis J. 2008 Nov; 27(11):986-92. PMID: 18833030; PMCID: PMC2749325.
  96. Nelson EJ, Chowdhury A, Flynn J, Schild S, Bourassa L, Shao Y, LaRocque RC, Calderwood SB, Qadri F, Camilli A. Transmission of Vibrio cholerae is antagonized by lytic phage and entry into the aquatic environment. PLoS Pathog. 2008 Oct; 4(10):e1000187. PMID: 18949027; PMCID: PMC2563029.
  97. Jayasekera CR, Harris JB, Bhuiyan S, Chowdhury F, Khan AI, Faruque AS, Larocque RC, Ryan ET, Ahmed R, Qadri F, Calderwood SB. Cholera toxin-specific memory B cell responses are induced in patients with dehydrating diarrhea caused by Vibrio cholerae O1. J Infect Dis. 2008 Oct 01; 198(7):1055-61. PMID: 18729782; PMCID: PMC2749301.
  98. Zahid MS, Udden SM, Faruque AS, Calderwood SB, Mekalanos JJ, Faruque SM. Effect of phage on the infectivity of Vibrio cholerae and emergence of genetic variants. Infect Immun. 2008 Nov; 76(11):5266-73. PMID: 18794293; PMCID: PMC2573317.
  99. Kudva IT, Calderwood SB, John M. Proteomics-based expression library screening - a platform technology for rapid discovery of pathogen-specific markers of infection. Expert Opin Med Diagn. 2008 Aug; 2(8):979-89. PMID: 23495870.
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  100. LaRocque RC, Krastins B, Harris JB, Lebrun LM, Parker KC, Chase M, Ryan ET, Qadri F, Sarracino D, Calderwood SB. Proteomic analysis of Vibrio cholerae in human stool. Infect Immun. 2008 Sep; 76(9):4145-51. PMID: 18591230; PMCID: PMC2519452.
  101. Harris JB, LaRocque RC, Chowdhury F, Khan AI, Logvinenko T, Faruque AS, Ryan ET, Qadri F, Calderwood SB. Susceptibility to Vibrio cholerae infection in a cohort of household contacts of patients with cholera in Bangladesh. PLoS Negl Trop Dis. 2008 Apr 09; 2(4):e221. PMID: 18398491; PMCID: PMC2271133.
  102. Rollins SM, Peppercorn A, Young JS, Drysdale M, Baresch A, Bikowski MV, Ashford DA, Quinn CP, Handfield M, Hillman JD, Lyons CR, Koehler TM, Calderwood SB, Ryan ET. Application of in vivo induced antigen technology (IVIAT) to Bacillus anthracis. PLoS One. 2008 Mar 19; 3(3):e1824. PMID: 18350160; PMCID: PMC2265799.
  103. Nelson EJ, Chowdhury A, Harris JB, Begum YA, Chowdhury F, Khan AI, Larocque RC, Bishop AL, Ryan ET, Camilli A, Qadri F, Calderwood SB. Complexity of rice-water stool from patients with Vibrio cholerae plays a role in the transmission of infectious diarrhea. Proc Natl Acad Sci U S A. 2007 Nov 27; 104(48):19091-6. PMID: 18024592; PMCID: PMC2141913.
  104. Schild S, Tamayo R, Nelson EJ, Qadri F, Calderwood SB, Camilli A. Genes induced late in infection increase fitness of Vibrio cholerae after release into the environment. Cell Host Microbe. 2007 Oct 11; 2(4):264-77. PMID: 18005744; PMCID: PMC2169296.
  105. Begun J, Gaiani JM, Rohde H, Mack D, Calderwood SB, Ausubel FM, Sifri CD. Staphylococcal biofilm exopolysaccharide protects against Caenorhabditis elegans immune defenses. PLoS Pathog. 2007 Apr; 3(4):e57. PMID: 17447841; PMCID: PMC1853117.
  106. Ghose C, Kalsy A, Sheikh A, Rollenhagen J, John M, Young J, Rollins SM, Qadri F, Calderwood SB, Kelly CP, Ryan ET. Transcutaneous immunization with Clostridium difficile toxoid A induces systemic and mucosal immune responses and toxin A-neutralizing antibodies in mice. Infect Immun. 2007 Jun; 75(6):2826-32. PMID: 17371854; PMCID: PMC1932889.
  107. Aperis G, Fuchs BB, Anderson CA, Warner JE, Calderwood SB, Mylonakis E. Galleria mellonella as a model host to study infection by the Francisella tularensis live vaccine strain. Microbes Infect. 2007 May; 9(6):729-34. PMID: 17400503; PMCID: PMC1974785.
  108. Rollenhagen JE, Kalsy A, Cerda F, John M, Harris JB, Larocque RC, Qadri F, Calderwood SB, Taylor RK, Ryan ET. Transcutaneous immunization with toxin-coregulated pilin A induces protective immunity against Vibrio cholerae O1 El Tor challenge in mice. Infect Immun. 2006 Oct; 74(10):5834-9. PMID: 16988262; PMCID: PMC1594919.
  109. Harris JB, Baresch-Bernal A, Rollins SM, Alam A, LaRocque RC, Bikowski M, Peppercorn AF, Handfield M, Hillman JD, Qadri F, Calderwood SB, Hohmann E, Breiman RF, Brooks WA, Ryan ET. Identification of in vivo-induced bacterial protein antigens during human infection with Salmonella enterica serovar Typhi. Infect Immun. 2006 Sep; 74(9):5161-8. PMID: 16926408; PMCID: PMC1594849.
  110. Ryan ET, Calderwood SB, Qadri F. Live attenuated oral cholera vaccines. Expert Rev Vaccines. 2006 Aug; 5(4):483-94. PMID: 16989629.
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  111. LaRocque RC, Harris JB, Ryan ET, Qadri F, Calderwood SB. Postgenomic approaches to cholera vaccine development. Expert Rev Vaccines. 2006 Jun; 5(3):337-46. PMID: 16827618.
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  112. Schwartz BS, Harris JB, Khan AI, Larocque RC, Sack DA, Malek MA, Faruque AS, Qadri F, Calderwood SB, Luby SP, Ryan ET. Diarrheal epidemics in Dhaka, Bangladesh, during three consecutive floods: 1988, 1998, and 2004. Am J Trop Med Hyg. 2006 Jun; 74(6):1067-73. PMID: 16760521; PMCID: PMC1626162.
  113. Kudva IT, Krastins B, Sheng H, Griffin RW, Sarracino DA, Tarr PI, Hovde CJ, Calderwood SB, John M. Proteomics-based expression library screening (PELS): a novel method for rapidly defining microbial immunoproteomes. Mol Cell Proteomics. 2006 Aug; 5(8):1514-9. PMID: 16737953; PMCID: PMC2754196.
  114. Butler SM, Nelson EJ, Chowdhury N, Faruque SM, Calderwood SB, Camilli A. Cholera stool bacteria repress chemotaxis to increase infectivity. Mol Microbiol. 2006 Apr; 60(2):417-26. PMID: 16573690; PMCID: PMC2754204.
  115. Sifri CD, Baresch-Bernal A, Calderwood SB, von Eiff C. Virulence of Staphylococcus aureus small colony variants in the Caenorhabditis elegans infection model. Infect Immun. 2006 Feb; 74(2):1091-6. PMID: 16428756; PMCID: PMC1360298.
  116. Tang RJ, Breger J, Idnurm A, Gerik KJ, Lodge JK, Heitman J, Calderwood SB, Mylonakis E. Cryptococcus neoformans gene involved in mammalian pathogenesis identified by a Caenorhabditis elegans progeny-based approach. Infect Immun. 2005 Dec; 73(12):8219-25. PMID: 16299318; PMCID: PMC1307092.
  117. Harris JB, Khan AI, LaRocque RC, Dorer DJ, Chowdhury F, Faruque AS, Sack DA, Ryan ET, Qadri F, Calderwood SB. Blood group, immunity, and risk of infection with Vibrio cholerae in an area of endemicity. Infect Immun. 2005 Nov; 73(11):7422-7. PMID: 16239542; PMCID: PMC1273892.
  118. Alam A, Larocque RC, Harris JB, Vanderspurt C, Ryan ET, Qadri F, Calderwood SB. Hyperinfectivity of human-passaged Vibrio cholerae can be modeled by growth in the infant mouse. Infect Immun. 2005 Oct; 73(10):6674-9. PMID: 16177344; PMCID: PMC1230955.
  119. Qadri F, Svennerholm AM, Shamsuzzaman S, Bhuiyan TR, Harris JB, Ghosh AN, Nair GB, Weintraub A, Faruque SM, Ryan ET, Sack DA, Calderwood SB. Reduction in capsular content and enhanced bacterial susceptibility to serum killing of Vibrio cholerae O139 associated with the 2002 cholera epidemic in Bangladesh. Infect Immun. 2005 Oct; 73(10):6577-83. PMID: 16177333; PMCID: PMC1230989.
  120. Kudva IT, Griffin RW, Garren JM, Calderwood SB, John M. Identification of a protein subset of the anthrax spore immunome in humans immunized with the anthrax vaccine adsorbed preparation. Infect Immun. 2005 Sep; 73(9):5685-96. PMID: 16113286; PMCID: PMC1231109.
  121. Larocque RC, Harris JB, Dziejman M, Li X, Khan AI, Faruque AS, Faruque SM, Nair GB, Ryan ET, Qadri F, Mekalanos JJ, Calderwood SB. Transcriptional profiling of Vibrio cholerae recovered directly from patient specimens during early and late stages of human infection. Infect Immun. 2005 Aug; 73(8):4488-93. PMID: 16040959; PMCID: PMC1201252.
  122. Mylonakis E, Moreno R, El Khoury JB, Idnurm A, Heitman J, Calderwood SB, Ausubel FM, Diener A. Galleria mellonella as a model system to study Cryptococcus neoformans pathogenesis. Infect Immun. 2005 Jul; 73(7):3842-50. PMID: 15972469; PMCID: PMC1168598.
  123. John M, Kudva IT, Griffin RW, Dodson AW, McManus B, Krastins B, Sarracino D, Progulske-Fox A, Hillman JD, Handfield M, Tarr PI, Calderwood SB. Use of in vivo-induced antigen technology for identification of Escherichia coli O157:H7 proteins expressed during human infection. Infect Immun. 2005 May; 73(5):2665-79. PMID: 15845468; PMCID: PMC1087376.
  124. Begun J, Sifri CD, Goldman S, Calderwood SB, Ausubel FM. Staphylococcus aureus virulence factors identified by using a high-throughput Caenorhabditis elegans-killing model. Infect Immun. 2005 Feb; 73(2):872-7. PMID: 15664928; PMCID: PMC547013.
  125. Rollins SM, Peppercorn A, Hang L, Hillman JD, Calderwood SB, Handfield M, Ryan ET. In vivo induced antigen technology (IVIAT). Cell Microbiol. 2005 Jan; 7(1):1-9. PMID: 15617518.
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  126. Khan WA, Rogers KA, Karim MM, Ahmed S, Hibberd PL, Calderwood SB, Ryan ET, Ward HD. Cryptosporidiosis among Bangladeshi children with diarrhea: a prospective, matched, case-control study of clinical features, epidemiology and systemic antibody responses. Am J Trop Med Hyg. 2004 Oct; 71(4):412-9. PMID: 15516636.
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  127. Mylonakis E, Idnurm A, Moreno R, El Khoury J, Rottman JB, Ausubel FM, Heitman J, Calderwood SB. Cryptococcus neoformans Kin1 protein kinase homologue, identified through a Caenorhabditis elegans screen, promotes virulence in mammals. Mol Microbiol. 2004 Oct; 54(2):407-19. PMID: 15469513.
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  128. Moy TI, Mylonakis E, Calderwood SB, Ausubel FM. Cytotoxicity of hydrogen peroxide produced by Enterococcus faecium. Infect Immun. 2004 Aug; 72(8):4512-20. PMID: 15271910; PMCID: PMC470665.
  129. Asaduzzaman M, Ryan ET, John M, Hang L, Khan AI, Faruque AS, Taylor RK, Calderwood SB, Qadri F. The major subunit of the toxin-coregulated pilus TcpA induces mucosal and systemic immunoglobulin A immune responses in patients with cholera caused by Vibrio cholerae O1 and O139. Infect Immun. 2004 Aug; 72(8):4448-54. PMID: 15271902; PMCID: PMC470637.
  130. Engelbert M, Mylonakis E, Ausubel FM, Calderwood SB, Gilmore MS. Contribution of gelatinase, serine protease, and fsr to the pathogenesis of Enterococcus faecalis endophthalmitis. Infect Immun. 2004 Jun; 72(6):3628-33. PMID: 15155673; PMCID: PMC415677.
  131. Kudva IT, Griffin RW, Murray M, John M, Perna NT, Barrett TJ, Calderwood SB. Insertions, deletions, and single-nucleotide polymorphisms at rare restriction enzyme sites enhance discriminatory power of polymorphic amplified typing sequences, a novel strain typing system for Escherichia coli O157:H7. J Clin Microbiol. 2004 Jun; 42(6):2388-97. PMID: 15184409; PMCID: PMC427851.
  132. Saha D, LaRocque RC, Khan AI, Harris JB, Begum YA, Akramuzzaman SM, Faruque AS, Ryan ET, Qadri F, Calderwood SB. Incomplete correlation of serum vibriocidal antibody titer with protection from Vibrio cholerae infection in urban Bangladesh. J Infect Dis. 2004 Jun 15; 189(12):2318-22. PMID: 15181581.
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  133. Apidianakis Y, Rahme LG, Heitman J, Ausubel FM, Calderwood SB, Mylonakis E. Challenge of Drosophila melanogaster with Cryptococcus neoformans and role of the innate immune response. Eukaryot Cell. 2004 Apr; 3(2):413-9. PMID: 15075271; PMCID: PMC387633.
  134. Sharathkumar A, Saunders EF, Dror Y, Grant R, Greenberg M, Weitzman S, Chan H, Calderwood S, Freedman MH, Doyle J. Allogeneic bone marrow transplantation vs chemotherapy for children with Philadelphia chromosome-positive acute lymphoblastic leukemia. Bone Marrow Transplant. 2004 Jan; 33(1):39-45. PMID: 14566329.
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  135. Qadri F, Ryan ET, Faruque AS, Ahmed F, Khan AI, Islam MM, Akramuzzaman SM, Sack DA, Calderwood SB. Antigen-specific immunoglobulin A antibodies secreted from circulating B cells are an effective marker for recent local immune responses in patients with cholera: comparison to antibody-secreting cell responses and other immunological markers. Infect Immun. 2003 Aug; 71(8):4808-14. PMID: 12874365; PMCID: PMC165990.
  136. Hang L, John M, Asaduzzaman M, Bridges EA, Vanderspurt C, Kirn TJ, Taylor RK, Hillman JD, Progulske-Fox A, Handfield M, Ryan ET, Calderwood SB. Use of in vivo-induced antigen technology (IVIAT) to identify genes uniquely expressed during human infection with Vibrio cholerae. Proc Natl Acad Sci U S A. 2003 Jul 08; 100(14):8508-13. PMID: 12826608; PMCID: PMC166259.
  137. Garsin DA, Villanueva JM, Begun J, Kim DH, Sifri CD, Calderwood SB, Ruvkun G, Ausubel FM. Long-lived C. elegans daf-2 mutants are resistant to bacterial pathogens. Science. 2003 Jun 20; 300(5627):1921. PMID: 12817143.
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  138. Mylonakis E, Ausubel FM, Tang RJ, Calderwood SB. The art of serendipity: killing of Caenorhabditis elegans by human pathogens as a model of bacterial and fungal pathogenesis. Expert Rev Anti Infect Ther. 2003 Jun; 1(1):167-73. PMID: 15482109.
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  139. Sifri CD, Begun J, Ausubel FM, Calderwood SB. Caenorhabditis elegans as a model host for Staphylococcus aureus pathogenesis. Infect Immun. 2003 Apr; 71(4):2208-17. PMID: 12654843; PMCID: PMC152095.
  140. Bina J, Zhu J, Dziejman M, Faruque S, Calderwood S, Mekalanos J. ToxR regulon of Vibrio cholerae and its expression in vibrios shed by cholera patients. Proc Natl Acad Sci U S A. 2003 Mar 04; 100(5):2801-6. PMID: 12601157; PMCID: PMC151421.
  141. Mylonakis E, Ausubel FM, Perfect JR, Heitman J, Calderwood SB. Killing of Caenorhabditis elegans by Cryptococcus neoformans as a model of yeast pathogenesis. Proc Natl Acad Sci U S A. 2002 Nov 26; 99(24):15675-80. PMID: 12438649; PMCID: PMC137775.
  142. Sifri CD, Mylonakis E, Singh KV, Qin X, Garsin DA, Murray BE, Ausubel FM, Calderwood SB. Virulence effect of Enterococcus faecalis protease genes and the quorum-sensing locus fsr in Caenorhabditis elegans and mice. Infect Immun. 2002 Oct; 70(10):5647-50. PMID: 12228293; PMCID: PMC128331.
  143. Mylonakis E, Engelbert M, Qin X, Sifri CD, Murray BE, Ausubel FM, Gilmore MS, Calderwood SB. The Enterococcus faecalis fsrB gene, a key component of the fsr quorum-sensing system, is associated with virulence in the rabbit endophthalmitis model. Infect Immun. 2002 Aug; 70(8):4678-81. PMID: 12117982; PMCID: PMC128160.
  144. Mylonakis E, Paliou M, Hohmann EL, Calderwood SB, Wing EJ. Listeriosis during pregnancy: a case series and review of 222 cases. Medicine (Baltimore). 2002 Jul; 81(4):260-9. PMID: 12169881.
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  145. John M, Bridges EA, Miller AO, Calderwood SB, Ryan ET. Comparison of mucosal and systemic humoral immune responses after transcutaneous and oral immunization strategies. Vaccine. 2002 Jun 21; 20(21-22):2720-6. PMID: 12034098.
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  146. Merrell DS, Butler SM, Qadri F, Dolganov NA, Alam A, Cohen MB, Calderwood SB, Schoolnik GK, Camilli A. Host-induced epidemic spread of the cholera bacterium. Nature. 2002 Jun 06; 417(6889):642-5. PMID: 12050664; PMCID: PMC2776822.
  147. Kudva IT, Evans PS, Perna NT, Barrett TJ, DeCastro GJ, Ausubel FM, Blattner FR, Calderwood SB. Polymorphic amplified typing sequences provide a novel approach to Escherichia coli O157:H7 strain typing. J Clin Microbiol. 2002 Apr; 40(4):1152-9. PMID: 11923324; PMCID: PMC140341.
  148. Kudva IT, Evans PS, Perna NT, Barrett TJ, Ausubel FM, Blattner FR, Calderwood SB. Strains of Escherichia coli O157:H7 differ primarily by insertions or deletions, not single-nucleotide polymorphisms. J Bacteriol. 2002 Apr; 184(7):1873-9. PMID: 11889093; PMCID: PMC134921.
  149. Al-Kasim FA, Thornley I, Rolland M, Lau W, Tsang R, Freedman MH, Saunders EF, Calderwood S, Doyle JJ. Single-centre experience with allogeneic bone marrow transplantation for acute lymphoblastic leukaemia in childhood: similar survival after matched-related and matched-unrelated donor transplants. Br J Haematol. 2002 Feb; 116(2):483-90. PMID: 11841456.
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  150. Choi JY, Sifri CD, Goumnerov BC, Rahme LG, Ausubel FM, Calderwood SB. Identification of virulence genes in a pathogenic strain of Pseudomonas aeruginosa by representational difference analysis. J Bacteriol. 2002 Feb; 184(4):952-61. PMID: 11807055; PMCID: PMC134824.
  151. Miller CB, Rowlings PA, Zhang MJ, Jones RJ, Piantadosi S, Keating A, Armitage JO, Calderwood S, Harris RE, Klein JP, Lazarus HM, Linker CA, Sobocinski KA, Weisdorf D, Horowitz MM. The effect of graft purging with 4-hydroperoxycyclophosphamide in autologous bone marrow transplantation for acute myelogenous leukemia. Exp Hematol. 2001 Nov; 29(11):1336-46. PMID: 11698130.
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  152. Mylonakis E, Calderwood SB. Infective endocarditis in adults. N Engl J Med. 2001 Nov 01; 345(18):1318-30. PMID: 11794152.
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  153. Park SY, Kelminson KL, Lee AK, Zhang P, Warner RE, Rehkopf DH, Calderwood SB, Koehler JE. Identification, characterization, and functional analysis of a gene encoding the ferric uptake regulation protein in Bartonella species. J Bacteriol. 2001 Oct; 183(19):5751-5. PMID: 11544240; PMCID: PMC95469.
  154. Garsin DA, Sifri CD, Mylonakis E, Qin X, Singh KV, Murray BE, Calderwood SB, Ausubel FM. A simple model host for identifying Gram-positive virulence factors. Proc Natl Acad Sci U S A. 2001 Sep 11; 98(19):10892-7. PMID: 11535834; PMCID: PMC58570.
  155. Allen UD, Tellier R, Doyle J, Petric M, Wasfy S, Kumar P, Calderwood S, Freedman M, Saunders F. The utility of plasma polymerase chain reaction for human herpes virus-6 among pediatric bone marrow transplant recipients: results of a pilot study. Bone Marrow Transplant. 2001 Sep; 28(5):473-7. PMID: 11593320.
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  156. Ryan ET, Bridges EA, Crean TI, Gausia K, Hamadani JD, Aziz A, Hawkes S, Begum M, Bogaerts J, Faruque SM, Salam MA, Fuchs GJ, Calderwood SB. Local production of anti-vibrio cholerae mucosal antibody in reproductive tract tissues after cholera. J Infect Dis. 2001 Sep 01; 184(5):643-7. PMID: 11494170.
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  157. Ryan ET, Calderwood SB. Cholera vaccines. J Travel Med. 2001 Mar-Apr; 8(2):82-91. PMID: 11285167.
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  158. Mylonakis E, Ryan ET, Calderwood SB. Clostridium difficile--Associated diarrhea: A review. Arch Intern Med. 2001 Feb 26; 161(4):525-33. PMID: 11252111.
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  159. Calderwood S, Kilpatrick L, Douglas SD, Freedman M, Smith-Whitley K, Rolland M, Kurtzberg J. Recombinant human granulocyte colony-stimulating factor therapy for patients with neutropenia and/or neutrophil dysfunction secondary to glycogen storage disease type 1b. Blood. 2001 Jan 15; 97(2):376-82. PMID: 11154211.
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  160. Behari J, Stagon L, Calderwood SB. pepA, a gene mediating pH regulation of virulence genes in Vibrio cholerae. J Bacteriol. 2001 Jan; 183(1):178-88. PMID: 11114915; PMCID: PMC94864.
  161. Fouladi M, Herman R, Rolland-Grinton M, Jones-Wallace D, Blanchette V, Calderwood S, Doyle J, Halperin D, Leaker M, Saunders EF, Zipursky A, Freedman MH. Improved survival in severe acquired aplastic anemia of childhood. Bone Marrow Transplant. 2000 Dec; 26(11):1149-56. PMID: 11149724.
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  162. Ryan ET, Calderwood SB. Cholera vaccines. Clin Infect Dis. 2000 Aug; 31(2):561-5. PMID: 10987721.
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  163. Ryan ET, Dhar U, Khan WA, Salam MA, Faruque AS, Fuchs GJ, Calderwood SB, Bennish ML. Mortality, morbidity, and microbiology of endemic cholera among hospitalized patients in Dhaka, Bangladesh. Am J Trop Med Hyg. 2000 Jul-Aug; 63(1-2):12-20. PMID: 11357989.
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  164. Murley YM, Behari J, Griffin R, Calderwood SB. Classical and El Tor biotypes of Vibrio cholerae differ in timing of transcription of tcpPH during growth in inducing conditions. Infect Immun. 2000 May; 68(5):3010-4. PMID: 10769005; PMCID: PMC97520.
  165. Rogers MB, Sexton JA, DeCastro GJ, Calderwood SB. Identification of an operon required for ferrichrome iron utilization in Vibrio cholerae. J Bacteriol. 2000 Apr; 182(8):2350-3. PMID: 10735886; PMCID: PMC111292.
  166. Singh IS, Viscardi RM, Kalvakolanu I, Calderwood S, Hasday JD. Inhibition of tumor necrosis factor-alpha transcription in macrophages exposed to febrile range temperature. A possible role for heat shock factor-1 as a negative transcriptional regulator. J Biol Chem. 2000 Mar 31; 275(13):9841-8. PMID: 10734139.
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  167. Butterton JR, Choi MH, Watnick PI, Carroll PA, Calderwood SB. Vibrio cholerae VibF is required for vibriobactin synthesis and is a member of the family of nonribosomal peptide synthetases. J Bacteriol. 2000 Mar; 182(6):1731-8. PMID: 10692380; PMCID: PMC94472.
  168. John M, Crean TI, Calderwood SB, Ryan ET. In vitro and in vivo analyses of constitutive and in vivo-induced promoters in attenuated vaccine and vector strains of Vibrio cholerae. Infect Immun. 2000 Mar; 68(3):1171-5. PMID: 10678922; PMCID: PMC97263.
  169. Dalal I, Reid B, Doyle J, Freedman M, Calderwood S, Saunders F, Roifman CM. Matched unrelated bone marrow transplantation for combined immunodeficiency. Bone Marrow Transplant. 2000 Mar; 25(6):613-21. PMID: 10734295.
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  170. Crean TI, John M, Calderwood SB, Ryan ET. Optimizing the germfree mouse model for in vivo evaluation of oral Vibrio cholerae vaccine and vector strains. Infect Immun. 2000 Feb; 68(2):977-81. PMID: 10639476; PMCID: PMC97235.
  171. Ryan ET, Crean TI, Kochi SK, John M, Luciano AA, Killeen KP, Klose KE, Calderwood SB. Development of a DeltaglnA balanced lethal plasmid system for expression of heterologous antigens by attenuated vaccine vector strains of Vibrio cholerae. Infect Immun. 2000 Jan; 68(1):221-6. PMID: 10603391; PMCID: PMC97124.
  172. Konadu E, Donohue-Rolfe A, Calderwood SB, Pozsgay V, Shiloach J, Robbins JB, Szu SC. Syntheses and immunologic properties of Escherichia coli O157 O-specific polysaccharide and Shiga toxin 1 B subunit conjugates in mice. Infect Immun. 1999 Nov; 67(11):6191-3. PMID: 10531288; PMCID: PMC97014.
  173. Bunin N, Saunders F, Leahey A, Doyle J, Calderwood S, Freedman MH. Alternative donor bone marrow transplantation for children with juvenile myelomonocytic leukemia. J Pediatr Hematol Oncol. 1999 Nov-Dec; 21(6):479-85. PMID: 10598658.
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  174. Murley YM, Carroll PA, Skorupski K, Taylor RK, Calderwood SB. Differential transcription of the tcpPH operon confers biotype-specific control of the Vibrio cholerae ToxR virulence regulon. Infect Immun. 1999 Oct; 67(10):5117-23. PMID: 10496885; PMCID: PMC96860.
  175. Rossi R, Shemie SD, Calderwood S. Prognosis of pediatric bone marrow transplant recipients requiring mechanical ventilation. Crit Care Med. 1999 Jun; 27(6):1181-6. PMID: 10397226.
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  176. Ryan ET, Crean TI, John M, Butterton JR, Clements JD, Calderwood SB. In vivo expression and immunoadjuvancy of a mutant of heat-labile enterotoxin of Escherichia coli in vaccine and vector strains of Vibrio cholerae. Infect Immun. 1999 Apr; 67(4):1694-701. PMID: 10085006; PMCID: PMC96516.
  177. Lin W, Fullner KJ, Clayton R, Sexton JA, Rogers MB, Calia KE, Calderwood SB, Fraser C, Mekalanos JJ. Identification of a vibrio cholerae RTX toxin gene cluster that is tightly linked to the cholera toxin prophage. Proc Natl Acad Sci U S A. 1999 Feb 02; 96(3):1071-6. PMID: 9927695; PMCID: PMC15352.
  178. Wong SM, Carroll PA, Rahme LG, Ausubel FM, Calderwood SB. Modulation of expression of the ToxR regulon in Vibrio cholerae by a member of the two-component family of response regulators. Infect Immun. 1998 Dec; 66(12):5854-61. PMID: 9826365; PMCID: PMC108741.
  179. Mylonakis E, Hohmann EL, Calderwood SB. Central nervous system infection with Listeria monocytogenes. 33 years' experience at a general hospital and review of 776 episodes from the literature. Medicine (Baltimore). 1998 Sep; 77(5):313-36. PMID: 9772921.
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  180. John MD, Hibberd PL, Karchmer AW, Sleeper LA, Calderwood SB. Staphylococcus aureus prosthetic valve endocarditis: optimal management and risk factors for death. Clin Infect Dis. 1998 Jun; 26(6):1302-9. PMID: 9636852.
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  181. Watnick PI, Butterton JR, Calderwood SB. The interaction of the Vibrio cholerae transcription factors, Fur and IrgB, with the overlapping promoters of two virulence genes, irgA and irgB. Gene. 1998 Mar 16; 209(1-2):65-70. PMID: 9524224.
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  182. Calia KE, Waldor MK, Calderwood SB. Use of representational difference analysis to identify genomic differences between pathogenic strains of Vibrio cholerae. Infect Immun. 1998 Feb; 66(2):849-52. PMID: 9453654; PMCID: PMC107982.
  183. Pegues DA, Colby C, Hibberd PL, Cohen LG, Ausubel FM, Calderwood SB, Hooper DC. The epidemiology of resistance to ofloxacin and oxacillin among clinical coagulase-negative staphylococcal isolates: analysis of risk factors and strain types. Clin Infect Dis. 1998 Jan; 26(1):72-9. PMID: 9455512.
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  184. Rahme LG, Tan MW, Le L, Wong SM, Tompkins RG, Calderwood SB, Ausubel FM. Use of model plant hosts to identify Pseudomonas aeruginosa virulence factors. Proc Natl Acad Sci U S A. 1997 Nov 25; 94(24):13245-50. PMID: 9371831; PMCID: PMC24294.
  185. Carroll PA, Tashima KT, Rogers MB, DiRita VJ, Calderwood SB. Phase variation in tcpH modulates expression of the ToxR regulon in Vibrio cholerae. Mol Microbiol. 1997 Sep; 25(6):1099-111. PMID: 9350866.
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  186. Ryan ET, Butterton JR, Zhang T, Baker MA, Stanley SL, Calderwood SB. Oral immunization with attenuated vaccine strains of Vibrio cholerae expressing a dodecapeptide repeat of the serine-rich Entamoeba histolytica protein fused to the cholera toxin B subunit induces systemic and mucosal antiamebic and anti-V. cholerae antibody responses in mice. Infect Immun. 1997 Aug; 65(8):3118-25. PMID: 9234763; PMCID: PMC175440.
  187. Ryan ET, Butterton JR, Smith RN, Carroll PA, Crean TI, Calderwood SB. Protective immunity against Clostridium difficile toxin A induced by oral immunization with a live, attenuated Vibrio cholerae vector strain. Infect Immun. 1997 Jul; 65(7):2941-9. PMID: 9199470; PMCID: PMC175412.
  188. Butterton JR, Ryan ET, Acheson DW, Calderwood SB. Coexpression of the B subunit of Shiga toxin 1 and EaeA from enterohemorrhagic Escherichia coli in Vibrio cholerae vaccine strains. Infect Immun. 1997 Jun; 65(6):2127-35. PMID: 9169742; PMCID: PMC175294.
  189. Rowlings PA, Przepiorka D, Klein JP, Gale RP, Passweg JR, Henslee-Downey PJ, Cahn JY, Calderwood S, Gratwohl A, Socié G, Abecasis MM, Sobocinski KA, Zhang MJ, Horowitz MM. IBMTR Severity Index for grading acute graft-versus-host disease: retrospective comparison with Glucksberg grade. Br J Haematol. 1997 Jun; 97(4):855-64. PMID: 9217189.
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  190. Watnick PI, Eto T, Takahashi H, Calderwood SB. Purification of Vibrio cholerae fur and estimation of its intracellular abundance by antibody sandwich enzyme-linked immunosorbent assay. J Bacteriol. 1997 Jan; 179(1):243-7. PMID: 8982004; PMCID: PMC178685.
  191. Carroll PA, Zhao G, Boyko SA, Winkler ME, Calderwood SB. Identification, sequencing, and enzymatic activity of the erythrose-4-phosphate dehydrogenase gene of Vibrio cholerae. J Bacteriol. 1997 Jan; 179(1):293-6. PMID: 8982014; PMCID: PMC178695.
  192. Calderwood SB, Baker MA, Carroll PA, Michel JL, Arbeit RD, Ausubel FM. Use of cleaved amplified polymorphic sequences to distinguish strains of Staphylococcus epidermidis. J Clin Microbiol. 1996 Nov; 34(11):2860-5. PMID: 8897202; PMCID: PMC229423.
  193. Butterton JR, Ryan ET, Shahin RA, Calderwood SB. Development of a germfree mouse model of Vibrio cholerae infection. Infect Immun. 1996 Oct; 64(10):4373-7. PMID: 8926115; PMCID: PMC174383.
  194. Calderwood S, Doyle JJ, Hitzler JK, Saunders EF, Freedman MH. Administration of recombinant human granulocyte-macrophage colony-stimulating factor after autologous bone marrow transplantation in children with acute myelogenous leukemia: a note of caution. Bone Marrow Transplant. 1996 Jul; 18(1):87-91. PMID: 8832000.
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  195. Tashima KT, Carroll PA, Rogers MB, Calderwood SB. Relative importance of three iron-regulated outer membrane proteins for in vivo growth of Vibrio cholerae. Infect Immun. 1996 May; 64(5):1756-61. PMID: 8613388; PMCID: PMC173989.
  196. Pozsgay V, Trinh L, Shiloach J, Robbins JB, Donohue-Rolfe A, Calderwood SB. Purification of subunit B of Shiga toxin using a synthetic trisaccharide-based affinity matrix. Bioconjug Chem. 1996 Jan-Feb; 7(1):45-55. PMID: 8741990.
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  197. Kontoyiannis DP, Calia KE, Basgoz N, Calderwood SB. Primary septicemia caused by Vibrio cholerae non-O1 acquired on Cape Cod, Massachusetts. Clin Infect Dis. 1995 Nov; 21(5):1330-3. PMID: 8589171.
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  198. Butterton JR, Beattie DT, Gardel CL, Carroll PA, Hyman T, Killeen KP, Mekalanos JJ, Calderwood SB. Heterologous antigen expression in Vibrio cholerae vector strains. Infect Immun. 1995 Jul; 63(7):2689-96. PMID: 7790086; PMCID: PMC173360.
  199. Butterton JR, Calderwood SB. Identification, cloning, and sequencing of a gene required for ferric vibriobactin utilization by Vibrio cholerae. J Bacteriol. 1994 Sep; 176(18):5631-8. PMID: 8083157; PMCID: PMC196765.
  200. Calderwood S, Romeyer F, Blanchette V, Chan H, Doyle J, Greenberg M, Lorenzana A, Malkin D, Saunders F, Weitzman S, et al. Concurrent RhGM-CSF does not offset myelosuppression from intensive chemotherapy: randomized placebo-controlled study in childhood acute lymphoblastic leukemia. Am J Hematol. 1994 Sep; 47(1):27-32. PMID: 8042612.
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  201. Lam MS, Litwin CM, Carroll PA, Calderwood SB. Vibrio cholerae fur mutations associated with loss of repressor activity: implications for the structural-functional relationships of fur. J Bacteriol. 1994 Aug; 176(16):5108-15. PMID: 8051024; PMCID: PMC196351.
  202. Calia KE, Murtagh M, Ferraro MJ, Calderwood SB. Comparison of Vibrio cholerae O139 with V. cholerae O1 classical and El Tor biotypes. Infect Immun. 1994 Apr; 62(4):1504-6. PMID: 7510671; PMCID: PMC186314.
  203. Litwin CM, Calderwood SB. Analysis of the complexity of gene regulation by fur in Vibrio cholerae. J Bacteriol. 1994 Jan; 176(1):240-8. PMID: 8282702; PMCID: PMC205036.
  204. Butterton JR, Boyko SA, Calderwood SB. Use of the Vibrio cholerae irgA gene as a locus for insertion and expression of heterologous antigens in cholera vaccine strains. Vaccine. 1993 Oct; 11(13):1327-35. PMID: 8296486.
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  205. Litwin CM, Calderwood SB. Role of iron in regulation of virulence genes. Clin Microbiol Rev. 1993 Apr; 6(2):137-49. PMID: 8472246; PMCID: PMC358274.
  206. Acheson DW, Calderwood SB, Boyko SA, Lincicome LL, Kane AV, Donohue-Rolfe A, Keusch GT. Comparison of Shiga-like toxin I B-subunit expression and localization in Escherichia coli and Vibrio cholerae by using trc or iron-regulated promoter systems. Infect Immun. 1993 Mar; 61(3):1098-104. PMID: 8432592; PMCID: PMC302844.
  207. Litwin CM, Calderwood SB. Cloning and genetic analysis of the Vibrio vulnificus fur gene and construction of a fur mutant by in vivo marker exchange. J Bacteriol. 1993 Feb; 175(3):706-15. PMID: 7678593; PMCID: PMC196209.
  208. Durand ML, Calderwood SB, Weber DJ, Miller SI, Southwick FS, Caviness VS, Swartz MN. Acute bacterial meningitis in adults. A review of 493 episodes. N Engl J Med. 1993 Jan 07; 328(1):21-8. PMID: 8416268.
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  209. Enzenauer RW, Calderwood S, Levin AV, Elder JE, Morin JD. Screening for fungal endophthalmitis in children at risk. Pediatrics. 1992 Sep; 90(3):451-7. PMID: 1518706.
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  210. Goldberg MB, Boyko SA, Butterton JR, Stoebner JA, Payne SM, Calderwood SB. Characterization of a Vibrio cholerae virulence factor homologous to the family of TonB-dependent proteins. Mol Microbiol. 1992 Aug; 6(16):2407-18. PMID: 1406279.
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  211. Butterton JR, Stoebner JA, Payne SM, Calderwood SB. Cloning, sequencing, and transcriptional regulation of viuA, the gene encoding the ferric vibriobactin receptor of Vibrio cholerae. J Bacteriol. 1992 Jun; 174(11):3729-38. PMID: 1317381; PMCID: PMC206063.
  212. Stoebner JA, Butterton JR, Calderwood SB, Payne SM. Identification of the vibriobactin receptor of Vibrio cholerae. J Bacteriol. 1992 May; 174(10):3270-4. PMID: 1315733; PMCID: PMC205995.
  213. Deresiewicz RL, Calderwood SB, Robertus JD, Collier RJ. Mutations affecting the activity of the Shiga-like toxin I A-chain. Biochemistry. 1992 Mar 31; 31(12):3272-80. PMID: 1554712.
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  214. Litwin CM, Boyko SA, Calderwood SB. Cloning, sequencing, and transcriptional regulation of the Vibrio cholerae fur gene. J Bacteriol. 1992 Mar; 174(6):1897-903. PMID: 1372314; PMCID: PMC205794.
  215. Hart PJ, Monzingo AF, Donohue-Rolfe A, Keusch GT, Calderwood SB, Robertus JD. Crystallization of the B chain of Shiga-like toxin I from Escherichia coli. J Mol Biol. 1991 Apr 20; 218(4):691-4. PMID: 2023244.
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  216. Goldberg MB, Boyko SA, Calderwood SB. Positive transcriptional regulation of an iron-regulated virulence gene in Vibrio cholerae. Proc Natl Acad Sci U S A. 1991 Feb 15; 88(4):1125-9. PMID: 1705025; PMCID: PMC50969.
  217. Rice LB, Calderwood SB, Eliopoulos GM, Farber BF, Karchmer AW. Enterococcal endocarditis: a comparison of prosthetic and native valve disease. Rev Infect Dis. 1991 Jan-Feb; 13(1):1-7. PMID: 2017607.
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  218. Goldberg MB, Boyko SA, Calderwood SB. Transcriptional regulation by iron of a Vibrio cholerae virulence gene and homology of the gene to the Escherichia coli fur system. J Bacteriol. 1990 Dec; 172(12):6863-70. PMID: 2174861; PMCID: PMC210804.
  219. Calderwood SB, Acheson DW, Goldberg MB, Boyko SA, Donohue-Rolfe A. A system for production and rapid purification of large amounts of the Shiga toxin/Shiga-like toxin I B subunit. Infect Immun. 1990 Sep; 58(9):2977-82. PMID: 2201641; PMCID: PMC313598.
  220. Pearson GD, DiRita VJ, Goldberg MB, Boyko SA, Calderwood SB, Mekalanos JJ. New attenuated derivatives of Vibrio cholerae. Res Microbiol. 1990 Sep-Oct; 141(7-8):893-9. PMID: 2101479.
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  221. Donnenberg MS, Calderwood SB, Donohue-Rolfe A, Keusch GT, Kaper JB. Construction and analysis of TnphoA mutants of enteropathogenic Escherichia coli unable to invade HEp-2 cells. Infect Immun. 1990 Jun; 58(6):1565-71. PMID: 2160428; PMCID: PMC258676.
  222. Jackson MP, Deresiewicz RL, Calderwood SB. Mutational analysis of the Shiga toxin and Shiga-like toxin II enzymatic subunits. J Bacteriol. 1990 Jun; 172(6):3346-50. PMID: 2345150; PMCID: PMC209145.
  223. Hunt C, Calderwood S. Characterization and sequence of a mouse hsp70 gene and its expression in mouse cell lines. Gene. 1990 Mar 15; 87(2):199-204. PMID: 2332169.
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  224. Goldberg MB, DiRita VJ, Calderwood SB. Identification of an iron-regulated virulence determinant in Vibrio cholerae, using TnphoA mutagenesis. Infect Immun. 1990 Jan; 58(1):55-60. PMID: 2152889; PMCID: PMC258408.
  225. Ruoff KL, Miller SI, Garner CV, Ferraro MJ, Calderwood SB. Bacteremia with Streptococcus bovis and Streptococcus salivarius: clinical correlates of more accurate identification of isolates. J Clin Microbiol. 1989 Feb; 27(2):305-8. PMID: 2915024; PMCID: PMC267297.
  226. Hovde CJ, Calderwood SB, Mekalanos JJ, Collier RJ. Evidence that glutamic acid 167 is an active-site residue of Shiga-like toxin I. Proc Natl Acad Sci U S A. 1988 Apr; 85(8):2568-72. PMID: 3357883; PMCID: PMC280038.
  227. Calderwood SB, Mekalanos JJ. Confirmation of the Fur operator site by insertion of a synthetic oligonucleotide into an operon fusion plasmid. J Bacteriol. 1988 Feb; 170(2):1015-7. PMID: 2828307; PMCID: PMC210760.
  228. Calderwood SB, Mekalanos JJ. Iron regulation of Shiga-like toxin expression in Escherichia coli is mediated by the fur locus. J Bacteriol. 1987 Oct; 169(10):4759-64. PMID: 3308853; PMCID: PMC213851.
  229. Caputo GM, Archer GL, Calderwood SB, DiNubile MJ, Karchmer AW. Native valve endocarditis due to coagulase-negative staphylococci. Clinical and microbiologic features. Am J Med. 1987 Oct; 83(4):619-25. PMID: 3674050.
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  230. Calderwood SB, Auclair F, Donohue-Rolfe A, Keusch GT, Mekalanos JJ. Nucleotide sequence of the Shiga-like toxin genes of Escherichia coli. Proc Natl Acad Sci U S A. 1987 Jul; 84(13):4364-8. PMID: 3299365; PMCID: PMC305089.
  231. Weber DJ, Calderwood SB, Karchmer AW, Pennington JE. Ampicillin versus cefamandole as initial therapy for community-acquired pneumonia. Antimicrob Agents Chemother. 1987 Jun; 31(6):876-82. PMID: 3304156; PMCID: PMC284203.
  232. DiNubile MJ, Calderwood SB, Steinhaus DM, Karchmer AW. Cardiac conduction abnormalities complicating native valve active infective endocarditis. Am J Cardiol. 1986 Dec 01; 58(13):1213-7. PMID: 3788810.
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  233. Calderwood SB, Swinski LA, Karchmer AW, Waternaux CM, Buckley MJ. Prosthetic valve endocarditis. Analysis of factors affecting outcome of therapy. J Thorac Cardiovasc Surg. 1986 Oct; 92(4):776-83. PMID: 3762207.
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  234. Calderwood SB, Swinski LA, Waternaux CM, Karchmer AW, Buckley MJ. Risk factors for the development of prosthetic valve endocarditis. Circulation. 1985 Jul; 72(1):31-7. PMID: 4006134.
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  235. Calderwood SB, Tung CC, Jackson E. Measurement of levels of aminoglycosides and vancomycin in serum in the presence of new beta-lactam antibiotics. J Clin Microbiol. 1984 May; 19(5):707-9. PMID: 6330168; PMCID: PMC271161.
  236. Ruoff KL, Fishman JA, Calderwood SB, Kunz LJ. Distribution and incidence of viridans streptococcal species in routine clinical specimens. Am J Clin Pathol. 1983 Dec; 80(6):854-8. PMID: 6637890.
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  237. Williamson R, Calderwood SB, Moellering RC, Tomasz A. Studies on the mechanism of intrinsic resistance to beta-lactam antibiotics in group D streptococci. J Gen Microbiol. 1983 Mar; 129(3):813-22. PMID: 6409985.
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  238. Calderwood SB, Gardella A, Philippon AM, Jacoby GA, Moellering RC. Effects of azlocillin in combination with clavulanic acid, sulbactam, and N-formimidoyl thienamycin against beta-lactamase-producing, carbenicillin-resistant Pseudomonas aeruginosa. Antimicrob Agents Chemother. 1982 Aug; 22(2):266-71. PMID: 6100423; PMCID: PMC183723.
  239. Calderwood SB, Wennersten C, Moellering RC. Resistance to antibiotic synergism in Streptococcus faecalis: further studies with amikacin and with a new amikacin derivative, 4'-deoxy, 6'-N-methylamikacin. Antimicrob Agents Chemother. 1981 Apr; 19(4):549-55. PMID: 6264851; PMCID: PMC181475.
  240. Calderwood SB, Moellering RC. Common adverse effects of antibacterial agents on major organ systems. Surg Clin North Am. 1980 Feb; 60(1):65-81. PMID: 6444768.
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