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profileEng H. Lo, PH.D.

TitleProfessor of Radiology
InstitutionMassachusetts General Hospital
DepartmentRadiology
AddressMass. General Hospital-East
Room 2401
149 13th Street
Charlestown MA 02129
Phone617/726-4043
Fax617/726-7830
vCardDownload vCard (login for email)

Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01AG055559     (LU, KUN PING)Aug 1, 2017 - May 31, 2022
NIH/NIA
Role of Tau Conformations in Vascular Contribution to Cognitive Impairment and Dementia
Role: Co-Principal Investigator

R01NS099620     (LO, ENG H.)Sep 1, 2016 - May 31, 2021
NIH/NINDS
Inflammatory Mechanisms of Brain - Lymphatic Signaling in Stroke
Role: Co-Principal Investigator

R01NS093415     (NING, MINGMING)Aug 1, 2015 - Jul 31, 2020
NIH/NINDS
Thrombolysis Profiles in tPA Response
Role: Principal Investigator

R01NS076694     (LO, ENG H.)Sep 1, 2011 - May 31, 2016
NIH/NINDS
Astrocyte-endothelial crosstalk after cerebral ischemia and hemorrhage
Role: Principal Investigator

RC2NS069335     (LO, ENG H.)Sep 30, 2009 - Aug 31, 2012
NIH/NINDS
Comparative transcriptome of brain blood vessels: age, hypertension and diabetes
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Deng W, Cao J, Chen L, McMullin D, Januzzi JL, Buonanno FS, Lo EH, Ning M. Plasma Glycoproteomic Study of Therapeutic Hypothermia Reveals Novel Markers Predicting Neurologic Outcome Post-cardiac Arrest. Transl Stroke Res. 2017 Aug 15. PMID: 28812241.
    View in: PubMed
  2. Yang S, Gu C, Mandeville ET, Dong Y, Esposito E, Zhang Y, Yang G, Shen Y, Fu X, Lo EH, Xie Z. Anesthesia and Surgery Impair Blood-Brain Barrier and Cognitive Function in Mice. Front Immunol. 2017; 8:902. PMID: 28848542.
    View in: PubMed
  3. Lule S, Wu L, McAllister LM, Edmiston WJ, Chung JY, Levy E, Zheng Y, Gough PJ, Bertin J, Degterev A, Lo EH, Whalen MJ. Genetic Inhibition of Receptor Interacting Protein Kinase-1 Reduces Cell Death and Improves Functional Outcome After Intracerebral Hemorrhage in Mice. Stroke. 2017 Sep; 48(9):2549-2556. PMID: 28765287.
    View in: PubMed
  4. Bosetti F, Koenig JI, Ayata C, Back SA, Becker K, Broderick JP, Carmichael ST, Cho S, Cipolla MJ, Corbett D, Corriveau RA, Cramer SC, Ferguson AR, Finklestein SP, Ford BD, Furie KL, Hemmen TM, Iadecola C, Jakeman LB, Janis S, Jauch EC, Johnston KC, Kochanek PM, Kohn H, Lo EH, Lyden PD, Mallard C, McCullough LD, McGavern LM, Meschia JF, Moy CS, Perez-Pinzon MA, Ramadan I, Savitz SI, Schwamm LH, Steinberg GK, Stenzel-Poore MP, Tymianski M, Warach S, Wechsler LR, Zhang JH, Koroshetz W. Translational Stroke Research: Vision and Opportunities. Stroke. 2017 Sep; 48(9):2632-2637. PMID: 28751554.
    View in: PubMed
  5. Wang Q, Yuan J, Yu Z, Lin L, Jiang Y, Cao Z, Zhuang P, Whalen MJ, Song B, Wang XJ, Li X, Lo EH, Xu Y, Wang X. FGF21 Attenuates High-Fat Diet-Induced Cognitive Impairment via Metabolic Regulation and Anti-inflammation of Obese Mice. Mol Neurobiol. 2017 Jul 15. PMID: 28712011.
    View in: PubMed
  6. Chou SH, Lan J, Esposito E, Ning M, Balaj L, Ji X, Lo EH, Hayakawa K. Extracellular Mitochondria in Cerebrospinal Fluid and Neurological Recovery After Subarachnoid Hemorrhage. Stroke. 2017 Aug; 48(8):2231-2237. PMID: 28663512.
    View in: PubMed
  7. Fan X, Jiang Y, Yu Z, Liu Q, Guo S, Sun X, van Leyen K, Ning M, Gao X, Lo EH, Wang X. Annexin A2 Plus Low-Dose Tissue Plasminogen Activator Combination Attenuates Cerebrovascular Dysfunction After Focal Embolic Stroke of Rats. Transl Stroke Res. 2017 Jun 04. PMID: 28580536.
    View in: PubMed
  8. Lin L, Desai R, Wang X, Lo EH, Xing C. Characteristics of primary rat microglia isolated from mixed cultures using two different methods. J Neuroinflammation. 2017 May 08; 14(1):101. PMID: 28482909.
    View in: PubMed
  9. Chan SJ, Love C, Spector M, Cool SM, Nurcombe V, Lo EH. Endogenous regeneration: Engineering growth factors for stroke. Neurochem Int. 2017 Jul; 107:57-65. PMID: 28411103.
    View in: PubMed
  10. Yang JM, Lee HS, Seo JH, Park JH, Gelman IH, Lo EH, Kim KW. Structural environment built by AKAP12+ colon mesenchymal cells drives M2 macrophages during inflammation recovery. Sci Rep. 2017 Feb 16; 7:42723. PMID: 28205544.
    View in: PubMed
  11. Liu Y, Zheng Y, Karatas H, Wang X, Foerch C, Lo EH, van Leyen K. 12/15-Lipoxygenase Inhibition or Knockout Reduces Warfarin-Associated Hemorrhagic Transformation After Experimental Stroke. Stroke. 2017 Feb; 48(2):445-451. PMID: 28057806.
    View in: PubMed
  12. Rost NS, Cougo P, Lorenzano S, Li H, Cloonan L, Bouts MJ, Lauer A, Etherton MR, Karadeli HH, Musolino PL, Copen WA, Arai K, Lo EH, Feske SK, Furie KL, Wu O. Diffuse microvascular dysfunction and loss of white matter integrity predict poor outcomes in patients with acute ischemic stroke. J Cereb Blood Flow Metab. 2017 Jan 01; 271678X17706449. PMID: 28481164.
    View in: PubMed
  13. Sun PZ, Ayata C, Lo EH. Fleeting footprints: finding MRI biomarkers of transient ischaemic attack. Brain. 2017 Jan; 140(Pt 1):8-10. PMID: 28031217.
    View in: PubMed
  14. Zhao S, Yu Z, Liu Y, Bai Y, Jiang Y, van Leyen K, Yang YG, Lok JM, Whalen MJ, Lo EH, Wang X. CD47 deficiency improves neurological outcomes of traumatic brain injury in mice. Neurosci Lett. 2017 Mar 16; 643:125-130. PMID: 27931776.
    View in: PubMed
  15. Yigitkanli K, Zheng Y, Pekcec A, Lo EH, van Leyen K. Increased 12/15-Lipoxygenase Leads to Widespread Brain Injury Following Global Cerebral Ischemia. Transl Stroke Res. 2017 Apr; 8(2):194-202. PMID: 27838820.
    View in: PubMed
  16. Takase H, Washida K, Hayakawa K, Arai K, Wang X, Lo EH, Lok J. Oligodendrogenesis after traumatic brain injury. Behav Brain Res. 2016 Nov 06. PMID: 27829126.
    View in: PubMed
  17. Le H, Ahn BJ, Lee HS, Shin A, Chae S, Lee SY, Shin MW, Lee EJ, Cha JH, Son T, Seo JH, Wee HJ, Lee HJ, Jang Y, Lo EH, Jeon S, Oh GT, Kim D, Kim KW. Disruption of Ninjurin1 Leads to Repetitive and Anxiety-Like Behaviors in Mice. Mol Neurobiol. 2016 Nov 05. PMID: 27815839.
    View in: PubMed
  18. Xing C, Hayakawa K, Lo EH. Mechanisms, Imaging, and Therapy in Stroke Recovery. Transl Stroke Res. 2017 Feb; 8(1):1-2. PMID: 27714670.
    View in: PubMed
  19. Zhou IY, Guo Y, Igarashi T, Wang Y, Mandeville E, Chan ST, Wen L, Vangel M, Lo EH, Ji X, Sun PZ. Fast diffusion kurtosis imaging (DKI) with Inherent COrrelation-based Normalization (ICON) enhances automatic segmentation of heterogeneous diffusion MRI lesion in acute stroke. NMR Biomed. 2016 Dec; 29(12):1670-1677. PMID: 27696558.
    View in: PubMed
  20. Choi YK, Maki T, Mandeville ET, Koh SH, Hayakawa K, Arai K, Kim YM, Whalen MJ, Xing C, Wang X, Kim KW, Lo EH. Dual effects of carbon monoxide on pericytes and neurogenesis in traumatic brain injury. Nat Med. 2016 Nov; 22(11):1335-1341. PMID: 27668935.
    View in: PubMed
  21. Hayakawa K, Esposito E, Wang X, Terasaki Y, Liu Y, Xing C, Ji X, Lo EH. Corrigendum: Transfer of mitochondria from astrocytes to neurons after stroke. Nature. 2016 Sep 14; 539(7627):123. PMID: 27629516.
    View in: PubMed
  22. Fujiwara N, Som AT, Pham LD, Lee BJ, Mandeville ET, Lo EH, Arai K. A free radical scavenger edaravone suppresses systemic inflammatory responses in a rat transient focal ischemia model. Neurosci Lett. 2016 Oct 28; 633:7-13. PMID: 27589890.
    View in: PubMed
  23. Hayakawa K, Esposito E, Wang X, Terasaki Y, Liu Y, Xing C, Ji X, Lo EH. Transfer of mitochondria from astrocytes to neurons after stroke. Nature. 2016 07 28; 535(7613):551-5. PMID: 27466127; PMCID: PMC4968589 [Available on 01/27/17].
  24. Guo Y, Zhou IY, Chan ST, Wang Y, Mandeville ET, Igarashi T, Lo EH, Ji X, Sun PZ. pH-sensitive MRI demarcates graded tissue acidification during acute stroke - pH specificity enhancement with magnetization transfer and relaxation-normalized amide proton transfer (APT) MRI. Neuroimage. 2016 Nov 01; 141:242-249. PMID: 27444569; PMCID: PMC5026952 [Available on 11/01/17].
  25. Xing C, Lo EH. Help-me signaling: Non-cell autonomous mechanisms of neuroprotection and neurorecovery. Prog Neurobiol. 2017 May; 152:181-199. PMID: 27079786.
    View in: PubMed
  26. Lo EH, Ning M. Mechanisms and challenges in translational stroke research. J Investig Med. 2016 Apr; 64(4):827-9. PMID: 26962212.
    View in: PubMed
  27. Orset C, Haelewyn B, Allan SM, Ansar S, Campos F, Cho TH, Durand A, El Amki M, Fatar M, Garcia-Yébenes I, Gauberti M, Grudzenski S, Lizasoain I, Lo E, Macrez R, Margaill I, Maysami S, Meairs S, Nighoghossian N, Orbe J, Paramo JA, Parienti JJ, Rothwell NJ, Rubio M, Waeber C, Young AR, Touzé E, Vivien D. Efficacy of Alteplase in a Mouse Model of Acute Ischemic Stroke: A Retrospective Pooled Analysis. Stroke. 2016 May; 47(5):1312-1318. PMID: 27032444; PMCID: PMC4846545 [Available on 05/01/17].
  28. Chen L, Deng W, Palacios I, Inglessis-Azuaje I, McMullin D, Zhou D, Lo EH, Buonanno F, Ning M. Patent foramen ovale (PFO), stroke and pregnancy. J Investig Med. 2016 Jun; 64(5):992-1000. PMID: 26988903.
    View in: PubMed
  29. Shindo A, Maki T, Mandeville ET, Liang AC, Egawa N, Itoh K, Itoh N, Borlongan M, Holder JC, Chuang TT, McNeish JD, Tomimoto H, Lok J, Lo EH, Arai K. Astrocyte-Derived Pentraxin 3 Supports Blood-Brain Barrier Integrity Under Acute Phase of Stroke. Stroke. 2016 Apr; 47(4):1094-100. PMID: 26965847; PMCID: PMC4811738 [Available on 04/01/17].
  30. Schlunk F, Pfeilschifter W, Yigitkanli K, Lo EH, Foerch C. Treatment with FTY720 has no beneficial effects on short-term outcome in an experimental model of intracerebral hemorrhage. Exp Transl Stroke Med. 2016; 8:1. PMID: 26893821; PMCID: PMC4758011.
  31. Guo S, Lok J, Zhao S, Leung W, Som AT, Hayakawa K, Wang Q, Xing C, Wang X, Ji X, Zhou Y, Lo EH. Effects of Controlled Cortical Impact on the Mouse Brain Vasculome. J Neurotrauma. 2016 Jul 15; 33(14):1303-16. PMID: 26528928; PMCID: PMC4931728 [Available on 07/15/17].
  32. Liang AC, Mandeville ET, Maki T, Shindo A, Som AT, Egawa N, Itoh K, Chuang TT, McNeish JD, Holder JC, Lok J, Lo EH, Arai K. Effects of Aging on Neural Stem/Progenitor Cells and Oligodendrocyte Precursor Cells After Focal Cerebral Ischemia in Spontaneously Hypertensive Rats. Cell Transplant. 2016; 25(4):705-14. PMID: 26811151.
    View in: PubMed
  33. Hayakawa K, Wang X, Lo EH. CD200 increases alternatively activated macrophages through cAMP-response element binding protein - C/EBP-beta signaling. J Neurochem. 2016 Mar; 136(5):900-6. PMID: 26670206; PMCID: PMC4755817 [Available on 03/01/17].
  34. Shindo A, Liang AC, Maki T, Miyamoto N, Tomimoto H, Lo EH, Arai K. Subcortical ischemic vascular disease: Roles of oligodendrocyte function in experimental models of subcortical white-matter injury. J Cereb Blood Flow Metab. 2016 Jan; 36(1):187-98. PMID: 25920960; PMCID: PMC4758561 [Available on 01/01/17].
  35. Liu N, Yu Z, Gao X, Song YS, Yuan J, Xun Y, Wang T, Yan F, Yuan S, Zhang J, Xiang S, Lo EH, Wang X. Establishment of Cell-Based Neuroglobin Promoter Reporter Assay for Neuroprotective Compounds Screening. CNS Neurol Disord Drug Targets. 2016; 15(5):629-39. PMID: 26996171.
    View in: PubMed
  36. Du Y, Deng W, Wang Z, Ning M, Zhang W, Zhou Y, Lo EH, Xing C. Differential subnetwork of chemokines/cytokines in human, mouse, and rat brain cells after oxygen-glucose deprivation. J Cereb Blood Flow Metab. 2017 Apr; 37(4):1425-1434. PMID: 27328691.
    View in: PubMed
  37. Itoh K, Maki T, Shindo A, Egawa N, Liang AC, Itoh N, Lo EH, Lok J, Arai K. Magnesium sulfate protects oligodendrocyte lineage cells in a rat cell-culture model of hypoxic-ischemic injury. Neurosci Res. 2016 May; 106:66-9. PMID: 26699082; PMCID: PMC4846506 [Available on 05/01/17].
  38. Jeong SY, Jeon R, Choi YK, Jung JE, Liang A, Xing C, Wang X, Lo EH, Song YS. Activation of microglial TLR3 promotes neuronal survival against cerebral ischemia. J Neurochem. 2015 Nov 25. PMID: 26603372.
    View in: PubMed
  39. Wu L, Ramirez SH, Andrews AM, Leung W, Itoh K, Wu J, Arai K, Lo EH, Lok J. Neuregulin1-ß decreases interleukin-1ß-induced RhoA activation, myosin light chain phosphorylation, and endothelial hyperpermeability. J Neurochem. 2016 Jan; 136(2):250-7. PMID: 26438054; PMCID: PMC4959605.
  40. Cho H, Seo JH, Wong KH, Terasaki Y, Park J, Bong K, Arai K, Lo EH, Irimia D. Three-Dimensional Blood-Brain Barrier Model for in vitro Studies of Neurovascular Pathology. Sci Rep. 2015 Oct 27; 5:15222. PMID: 26503597; PMCID: PMC4622078.
  41. Jiang Y, Fan X, Yu Z, Liao Z, Wang XS, van Leyen K, Sun X, Lo EH, Wang X. Combination Low-Dose Tissue-Type Plasminogen Activator Plus Annexin A2 for Improving Thrombolytic Stroke Therapy. Front Cell Neurosci. 2015; 9:397. PMID: 26528130; PMCID: PMC4604305.
  42. van Leyen K, Arai K, Wang X, Lo EH. From cell to cell: the breakdown of intercellular connectivity after stroke and how to regain contact. Brain Res. 2015 Oct 14; 1623:1-2. PMID: 26363519.
    View in: PubMed
  43. Chen F, Du Y, Esposito E, Liu Y, Guo S, Wang X, Lo EH, Xing C, Ji X. Effects of Focal Cerebral Ischemia on Exosomal Versus Serum miR126. Transl Stroke Res. 2015 Dec; 6(6):478-84. PMID: 26449616.
    View in: PubMed
  44. Hayakawa K, Pham LD, Seo JH, Miyamoto N, Maki T, Terasaki Y, Sakadžic S, Boas D, van Leyen K, Waeber C, Kim KW, Arai K, Lo EH. CD200 restrains macrophage attack on oligodendrocyte precursors via toll-like receptor 4 downregulation. J Cereb Blood Flow Metab. 2016 Apr; 36(4):781-93. PMID: 26661156; PMCID: PMC4821018 [Available on 04/01/17].
  45. Koh SH, Liang AC, Takahashi Y, Maki T, Shindo A, Osumi N, Zhao J, Lin H, Holder JC, Chuang TT, McNeish JD, Arai K, Lo EH. Differential Effects of Isoxazole-9 on Neural Stem/Progenitor Cells, Oligodendrocyte Precursor Cells, and Endothelial Progenitor Cells. PLoS One. 2015; 10(9):e0138724. PMID: 26407349; PMCID: PMC4583469.
  46. Musolino PL, Gong Y, Snyder JM, Jimenez S, Lok J, Lo EH, Moser AB, Grabowski EF, Frosch MP, Eichler FS. Brain endothelial dysfunction in cerebral adrenoleukodystrophy. Brain. 2015 Nov; 138(Pt 11):3206-20. PMID: 26377633; PMCID: PMC4731416 [Available on 11/01/16].
  47. Koh SH, Lo EH. The Role of the PI3K Pathway in the Regeneration of the Damaged Brain by Neural Stem Cells after Cerebral Infarction. J Clin Neurol. 2015 Oct; 11(4):297-304. PMID: 26320845; PMCID: PMC4596106.
  48. Hayakawa K, Lo EH. Brain-peripheral cell crosstalk in white matter damage and repair. Biochim Biophys Acta. 2016 May; 1862(5):901-8. PMID: 26277436; PMCID: PMC4752923 [Available on 05/01/17].
  49. Esposito E, Hayakawa K, Maki T, Arai K, Lo EH. Effects of Postconditioning on Neurogenesis and Angiogenesis During the Recovery Phase After Focal Cerebral Ischemia. Stroke. 2015 Sep; 46(9):2691-4. PMID: 26243221; PMCID: PMC4604446.
  50. Jung JE, Karatas H, Liu Y, Yalcin A, Montaner J, Lo EH, van Leyen K. STAT-dependent upregulation of 12/15-lipoxygenase contributes to neuronal injury after stroke. J Cereb Blood Flow Metab. 2015 Dec; 35(12):2043-51. PMID: 26174325; PMCID: PMC4671126 [Available on 12/01/16].
  51. Jiang Y, Fan X, Yu Z, Cheng C, Wang XS, Lo EH, Sun X, Wang X. Low dose tPA plus annexin A2 combination attenuates tPA delayed treatment-associated hemorrhage and improves recovery in rat embolic focal stroke. Neurosci Lett. 2015 Aug 18; 602:73-8. PMID: 26149229; PMCID: PMC4739853.
  52. Lin H, Fang H, Wang J, Meng Q, Dai X, Wu S, Luo J, Pu D, Chen L, Minick D, Arai K, Mandeville ET, Lo E, Holder JC, Chuang TT, Zhao J. Discovery of a novel 2,3,11,11a-tetrahydro-1H-pyrazino[1,2-b]isoquinoline-1,4(6H)-dione series promoting neurogenesis of human neural progenitor cells. Bioorg Med Chem Lett. 2015 Sep 01; 25(17):3748-53. PMID: 26142946.
    View in: PubMed
  53. Maki T, Takahashi Y, Miyamoto N, Liang AC, Ihara M, Lo EH, Arai K. Adrenomedullin promotes differentiation of oligodendrocyte precursor cells into myelin-basic-protein expressing oligodendrocytes under pathological conditions in vitro. Stem Cell Res. 2015 Jul; 15(1):68-74. PMID: 26002630; PMCID: PMC4516627.
  54. Chan SJ, Chai C, Lim TW, Yamamoto M, Lo EH, Lai MK, Wong PT. Cystathionine ß-synthase inhibition is a potential therapeutic approach to treatment of ischemic injury. ASN Neuro. 2015 Mar-Apr; 7(2). PMID: 25873304; PMCID: PMC4397212.
  55. Yu Z, Li Z, Liu N, Jizhang Y, McCarthy TJ, Tedford CE, Lo EH, Wang X. Near infrared radiation protects against oxygen-glucose deprivation-induced neurotoxicity by down-regulating neuronal nitric oxide synthase (nNOS) activity in vitro. Metab Brain Dis. 2015 Jun; 30(3):829-37. PMID: 25796222.
    View in: PubMed
  56. von Bornstädt D, Houben T, Seidel JL, Zheng Y, Dilekoz E, Qin T, Sandow N, Kura S, Eikermann-Haerter K, Endres M, Boas DA, Moskowitz MA, Lo EH, Dreier JP, Woitzik J, Sakadžic S, Ayata C. Supply-demand mismatch transients in susceptible peri-infarct hot zones explain the origins of spreading injury depolarizations. Neuron. 2015 Mar 04; 85(5):1117-31. PMID: 25741731; PMCID: PMC4351476.
  57. Gagnon L, Sakadžic S, Lesage F, Musacchia JJ, Lefebvre J, Fang Q, Yücel MA, Evans KC, Mandeville ET, Cohen-Adad J, Polimeni JR, Yaseen MA, Lo EH, Greve DN, Buxton RB, Dale AM, Devor A, Boas DA. Quantifying the microvascular origin of BOLD-fMRI from first principles with two-photon microscopy and an oxygen-sensitive nanoprobe. J Neurosci. 2015 Feb 25; 35(8):3663-75. PMID: 25716864; PMCID: PMC4339366.
  58. Wu L, Du Y, Lok J, Lo EH, Xing C. Lipocalin-2 enhances angiogenesis in rat brain endothelial cells via reactive oxygen species and iron-dependent mechanisms. J Neurochem. 2015 Mar; 132(6):622-8. PMID: 25557118; PMCID: PMC4359653.
  59. Lopez MF, Krastins B, Sarracino DA, Byram G, Vogelsang MS, Prakash A, Peterman S, Ahmad S, Vadali G, Deng W, Inglessis I, Wickham T, Feeney K, Dec GW, Palacios I, Buonanno FS, Lo EH, Ning M. Proteomic signatures of serum albumin-bound proteins from stroke patients with and without endovascular closure of PFO are significantly different and suggest a novel mechanism for cholesterol efflux. Clin Proteomics. 2015; 12(1):2. PMID: 25678897; PMCID: PMC4305391.
  60. Sakadžic S, Mandeville ET, Gagnon L, Musacchia JJ, Yaseen MA, Yucel MA, Lefebvre J, Lesage F, Dale AM, Eikermann-Haerter K, Ayata C, Srinivasan VJ, Lo EH, Devor A, Boas DA. Large arteriolar component of oxygen delivery implies a safe margin of oxygen supply to cerebral tissue. Nat Commun. 2014 Dec 08; 5:5734. PMID: 25483924; PMCID: PMC4260810.
  61. Lok J, Wang XS, Xing CH, Maki TK, Wu LM, Guo SZ, Noviski N, Arai K, Whalen MJ, Lo EH, Wang XY. Targeting the neurovascular unit in brain trauma. CNS Neurosci Ther. 2015 Apr; 21(4):304-8. PMID: 25475543.
    View in: PubMed
  62. Schlunk F, Schulz E, Lauer A, Yigitkanli K, Pfeilschifter W, Steinmetz H, Lo EH, Foerch C. Warfarin pretreatment reduces cell death and MMP-9 activity in experimental intracerebral hemorrhage. Transl Stroke Res. 2015 Apr; 6(2):133-9. PMID: 25424451.
    View in: PubMed
  63. Cha JH, Wee HJ, Seo JH, Ahn BJ, Park JH, Yang JM, Lee SW, Lee OH, Lee HJ, Gelman IH, Arai K, Lo EH, Kim KW. Prompt meningeal reconstruction mediated by oxygen-sensitive AKAP12 scaffolding protein after central nervous system injury. Nat Commun. 2014 Sep 17; 5:4952. PMID: 25229625; PMCID: PMC4348065.
  64. Sun PZ, Wang Y, Mandeville E, Chan ST, Lo EH, Ji X. Validation of fast diffusion kurtosis MRI for imaging acute ischemia in a rodent model of stroke. NMR Biomed. 2014 Nov; 27(11):1413-8. PMID: 25208309; PMCID: PMC4201862.
  65. Fan X, Jiang Y, Yu Z, Yuan J, Sun X, Xiang S, Lo EH, Wang X. Combination approaches to attenuate hemorrhagic transformation after tPA thrombolytic therapy in patients with poststroke hyperglycemia/diabetes. Adv Pharmacol. 2014; 71:391-410. PMID: 25307224.
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  66. Seo JH, Maki T, Maeda M, Miyamoto N, Liang AC, Hayakawa K, Pham LD, Suwa F, Taguchi A, Matsuyama T, Ihara M, Kim KW, Lo EH, Arai K. Oligodendrocyte precursor cells support blood-brain barrier integrity via TGF-ß signaling. PLoS One. 2014; 9(7):e103174. PMID: 25078775; PMCID: PMC4117639.
  67. Maki T, Okamoto Y, Carare RO, Hase Y, Hattori Y, Hawkes CA, Saito S, Yamamoto Y, Terasaki Y, Ishibashi-Ueda H, Taguchi A, Takahashi R, Miyakawa T, Kalaria RN, Lo EH, Arai K, Ihara M. Phosphodiesterase III inhibitor promotes drainage of cerebrovascular ß-amyloid. Ann Clin Transl Neurol. 2014 Aug; 1(8):519-33. PMID: 25356424; PMCID: PMC4184555.
  68. Zhu X, Park J, Golinski J, Qiu J, Khuman J, Lee CC, Lo EH, Degterev A, Whalen MJ. Role of Akt and mammalian target of rapamycin in functional outcome after concussive brain injury in mice. J Cereb Blood Flow Metab. 2014 Sep; 34(9):1531-9. PMID: 24938400; PMCID: PMC4158669.
  69. Ahn BJ, Le H, Shin MW, Bae SJ, Lee EJ, Lee SY, Yang JH, Wee HJ, Cha JH, Seo JH, Lee HS, Lee HJ, Arai K, Lo EH, Jeon S, Oh GT, Kim WJ, Ryu JK, Suh JK, Kim KW. Ninjurin1 enhances the basal motility and transendothelial migration of immune cells by inducing protrusive membrane dynamics. J Biol Chem. 2014 Aug 08; 289(32):21926-36. PMID: 24917672; PMCID: PMC4139210.
  70. Xing C, Wang X, Cheng C, Montaner J, Mandeville E, Leung W, van Leyen K, Lok J, Wang X, Lo EH. Neuronal production of lipocalin-2 as a help-me signal for glial activation. Stroke. 2014 Jul; 45(7):2085-92. PMID: 24916903; PMCID: PMC4122238.
  71. Wu L, Walas S, Leung W, Sykes DB, Wu J, Lo EH, Lok J. Neuregulin1-ß decreases IL-1ß-induced neutrophil adhesion to human brain microvascular endothelial cells. Transl Stroke Res. 2015 Apr; 6(2):116-24. PMID: 24863743; PMCID: PMC4247352.
  72. Miller BF, Keles E, Tien L, Zhang J, Kaplan D, Lo EH, Whalen MJ. The pharmacokinetics and pharmacodynamics of Kollidon VA64 dissociate its protective effects from membrane resealing after controlled cortical impact in mice. J Cereb Blood Flow Metab. 2014 Aug; 34(8):1347-53. PMID: 24824916; PMCID: PMC4126095.
  73. Rai G, Joshi N, Jung JE, Liu Y, Schultz L, Yasgar A, Perry S, Diaz G, Zhang Q, Kenyon V, Jadhav A, Simeonov A, Lo EH, van Leyen K, Maloney DJ, Holman TR. Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies. J Med Chem. 2014 May 22; 57(10):4035-48. PMID: 24684213; PMCID: PMC4033661.
  74. Cha JH, Wee HJ, Seo JH, Ahn BJ, Park JH, Yang JM, Lee SW, Kim EH, Lee OH, Heo JH, Lee HJ, Gelman IH, Arai K, Lo EH, Kim KW. AKAP12 mediates barrier functions of fibrotic scars during CNS repair. PLoS One. 2014; 9(4):e94695. PMID: 24760034; PMCID: PMC3997571.
  75. Yu Z, Liu N, Zhao J, Li Y, McCarthy TJ, Tedford CE, Lo EH, Wang X. Near infrared radiation rescues mitochondrial dysfunction in cortical neurons after oxygen-glucose deprivation. Metab Brain Dis. 2015 Apr; 30(2):491-6. PMID: 24599760; PMCID: PMC4156924.
  76. Liu Q, Qiu J, Liang M, Golinski J, van Leyen K, Jung JE, You Z, Lo EH, Degterev A, Whalen MJ. Akt and mTOR mediate programmed necrosis in neurons. Cell Death Dis. 2014 Feb 27; 5:e1084. PMID: 24577082; PMCID: PMC3944276.
  77. Schaefer JH, Leung W, Wu L, Van Cott EM, Lok J, Whalen M, van Leyen K, Lauer A, van Ryn J, Lo EH, Foerch C. Translational insights into traumatic brain injury occurring during dabigatran or warfarin anticoagulation. J Cereb Blood Flow Metab. 2014 May; 34(5):870-5. PMID: 24549187; PMCID: PMC4013768.
  78. Corbin ZA, Rost NS, Lorenzano S, Kernan WN, Parides MK, Blumberg JB, Milbury PE, Arai K, Hartdegen SN, Lo EH, Feske SK, Furie KL. White matter hyperintensity volume correlates with matrix metalloproteinase-2 in acute ischemic stroke. J Stroke Cerebrovasc Dis. 2014 Jul; 23(6):1300-6. PMID: 24439130; PMCID: PMC4058345.
  79. Chou SH, Lo EH, Ning M. Plasma-type gelsolin in subarachnoid hemorrhage: novel biomarker today, therapeutic target tomorrow? Crit Care. 2014 Jan 06; 18(1):101. PMID: 24393331; PMCID: PMC4056622.
  80. Terasaki Y, Liu Y, Hayakawa K, Pham LD, Lo EH, Ji X, Arai K. Mechanisms of neurovascular dysfunction in acute ischemic brain. Curr Med Chem. 2014; 21(18):2035-42. PMID: 24372202; PMCID: PMC4066327.
  81. Guo S, Lok J, Liu Y, Hayakawa K, Leung W, Xing C, Ji X, Lo EH. Assays to examine endothelial cell migration, tube formation, and gene expression profiles. Methods Mol Biol. 2014; 1135:393-402. PMID: 24510881; PMCID: PMC4035906.
  82. Lee JH, Zheng Y, von Bornstadt D, Wei Y, Balcioglu A, Daneshmand A, Yalcin N, Yu E, Herisson F, Atalay YB, Kim MH, Ahn YJ, Balkaya M, Sweetnam P, Schueller O, Poyurovsky MV, Kim HH, Lo EH, Furie KL, Ayata C. Selective ROCK2 Inhibition In Focal Cerebral Ischemia. Ann Clin Transl Neurol. 2014 Jan 01; 1(1):2-14. PMID: 24466563.
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  83. Hayakawa K, Pham LD, Arai K, Lo EH. Reactive astrocytes promote adhesive interactions between brain endothelium and endothelial progenitor cells via HMGB1 and beta-2 integrin signaling. Stem Cell Res. 2014 Mar; 12(2):531-8. PMID: 24480450; PMCID: PMC3966549.
  84. Maki T, Liang AC, Miyamoto N, Lo EH, Arai K. Mechanisms of oligodendrocyte regeneration from ventricular-subventricular zone-derived progenitor cells in white matter diseases. Front Cell Neurosci. 2013 Dec 26; 7:275. PMID: 24421755; PMCID: PMC3872787.
  85. Wang X, Fan X, Yu Z, Liao Z, Zhao J, Mandeville E, Guo S, Lo EH, Wang X. Effects of tissue plasminogen activator and annexin A2 combination therapy on long-term neurological outcomes of rat focal embolic stroke. Stroke. 2014 Feb; 45(2):619-22. PMID: 24368559; PMCID: PMC3912312.
  86. Ahn BJ, Le H, Shin MW, Bae SJ, Lee EJ, Wee HJ, Cha JH, Lee HJ, Lee HS, Kim JH, Kim CY, Seo JH, Lo EH, Jeon S, Lee MN, Oh GT, Yin GN, Ryu JK, Suh JK, Kim KW. Ninjurin1 deficiency attenuates susceptibility of experimental autoimmune encephalomyelitis in mice. J Biol Chem. 2014 Feb 07; 289(6):3328-38. PMID: 24347169; PMCID: PMC3916537.
  87. Lo EH. 2013 Thomas Willis Award Lecture: Causation and collaboration for stroke research. Stroke. 2014 Jan; 45(1):305-8. PMID: 24203848; PMCID: PMC4067238.
  88. Esposito E, Mandeville ET, Lo EH. Lower doses of isoflurane treatment has no beneficial effects in a rat model of intracerebral hemorrhage. BMC Neurosci. 2013 Oct 20; 14:129. PMID: 24138708; PMCID: PMC3924354.
  89. Miyamoto N, Pham LD, Seo JH, Kim KW, Lo EH, Arai K. Crosstalk between cerebral endothelium and oligodendrocyte. Cell Mol Life Sci. 2014 Mar; 71(6):1055-66. PMID: 24132511; PMCID: PMC3944198.
  90. Devor A, Bandettini PA, Boas DA, Bower JM, Buxton RB, Cohen LB, Dale AM, Einevoll GT, Fox PT, Franceschini MA, Friston KJ, Fujimoto JG, Geyer MA, Greenberg JH, Halgren E, Hämäläinen MS, Helmchen F, Hyman BT, Jasanoff A, Jernigan TL, Judd LL, Kim SG, Kleinfeld D, Kopell NJ, Kutas M, Kwong KK, Larkum ME, Lo EH, Magistretti PJ, Mandeville JB, Masliah E, Mitra PP, Mobley WC, Moskowitz MA, Nimmerjahn A, Reynolds JH, Rosen BR, Salzberg BM, Schaffer CB, Silva GA, So PT, Spitzer NC, Tootell RB, Van Essen DC, Vanduffel W, Vinogradov SA, Wald LL, Wang LV, Weber B, Yodh AG. The challenge of connecting the dots in the B.R.A.I.N. Neuron. 2013 Oct 16; 80(2):270-4. PMID: 24139032; PMCID: PMC3864648.
  91. Miyamoto N, Maki T, Pham LD, Hayakawa K, Seo JH, Mandeville ET, Mandeville JB, Kim KW, Lo EH, Arai K. Oxidative stress interferes with white matter renewal after prolonged cerebral hypoperfusion in mice. Stroke. 2013 Dec; 44(12):3516-21. PMID: 24072001; PMCID: PMC3985753.
  92. Li Q, Atochin D, Kashiwagi S, Earle J, Wang A, Mandeville E, Hayakawa K, d'Uscio LV, Lo EH, Katusic Z, Sessa W, Huang PL. Deficient eNOS phosphorylation is a mechanism for diabetic vascular dysfunction contributing to increased stroke size. Stroke. 2013 Nov; 44(11):3183-8. PMID: 23988642; PMCID: PMC3864831.
  93. Esposito E, Mandeville ET, Hayakawa K, Singhal AB, Lo EH. Effects of normobaric oxygen on the progression of focal cerebral ischemia in rats. Exp Neurol. 2013 Nov; 249:33-8. PMID: 23958492; PMCID: PMC3805377.
  94. Srinivasan VJ, Mandeville ET, Can A, Blasi F, Climov M, Daneshmand A, Lee JH, Yu E, Radhakrishnan H, Lo EH, Sakadžic S, Eikermann-Haerter K, Ayata C. Multiparametric, longitudinal optical coherence tomography imaging reveals acute injury and chronic recovery in experimental ischemic stroke. PLoS One. 2013; 8(8):e71478. PMID: 23940761; PMCID: PMC3737090.
  95. Won SY, Schlunk F, Dinkel J, Karatas H, Leung W, Hayakawa K, Lauer A, Steinmetz H, Lo EH, Foerch C, Gupta R. Imaging of contrast medium extravasation in anticoagulation-associated intracerebral hemorrhage with dual-energy computed tomography. Stroke. 2013 Oct; 44(10):2883-90. PMID: 23920016; PMCID: PMC3985727.
  96. Miyamoto N, Pham LD, Hayakawa K, Matsuzaki T, Seo JH, Magnain C, Ayata C, Kim KW, Boas D, Lo EH, Arai K. Age-related decline in oligodendrogenesis retards white matter repair in mice. Stroke. 2013 Sep; 44(9):2573-8. PMID: 23881957; PMCID: PMC3818687.
  97. Navaratna D, Fan X, Leung W, Lok J, Guo S, Xing C, Wang X, Lo EH. Cerebrovascular degradation of TRKB by MMP9 in the diabetic brain. J Clin Invest. 2013 Aug; 123(8):3373-7. PMID: 23867621; PMCID: PMC3726155.
  98. Kuruppu S, Chou SH, Feske SK, Suh S, Hanchapola I, Lo EH, Ning M, Smith AI. Soluble and catalytically active endothelin converting enzyme-1 is present in cerebrospinal fluid of subarachnoid hemorrhage patients. Mol Cell Proteomics. 2014 Apr; 13(4):1091-4. PMID: 23816989; PMCID: PMC3977186.
  99. Ning MM, Lopez M, Sarracino D, Cao J, Karchin M, McMullin D, Wang X, Buonanno FS, Lo EH. Pharmaco-proteomics opportunities for individualizing neurovascular treatment. Neurol Res. 2013 Jun; 35(5):448-56. PMID: 23711324; PMCID: PMC4153693.
  100. Maki T, Hayakawa K, Pham LD, Xing C, Lo EH, Arai K. Biphasic mechanisms of neurovascular unit injury and protection in CNS diseases. CNS Neurol Disord Drug Targets. 2013 May 01; 12(3):302-15. PMID: 23469847; PMCID: PMC3845030.
  101. Ning M, Lo EH, Ning PC, Xu SY, McMullin D, Demirjian Z, Inglessis I, Dec GW, Palacios I, Buonanno FS. The brain's heart - therapeutic opportunities for patent foramen ovale (PFO) and neurovascular disease. Pharmacol Ther. 2013 Aug; 139(2):111-23. PMID: 23528225; PMCID: PMC3740210.
  102. Dai H, Yu Z, Fan X, Liu N, Yan M, Chen Z, Lo EH, Hajjar KA, Wang X. Dysfunction of annexin A2 contributes to hyperglycaemia-induced loss of human endothelial cell surface fibrinolytic activity. Thromb Haemost. 2013 Jun; 109(6):1070-8. PMID: 23572070; PMCID: PMC4066328.
  103. Meng R, Wang X, Hussain M, Dornbos D, Meng L, Liu Y, Wu Y, Ning M, Ferdinando S B, Lo EH, Ding Y, Ji X. Evaluation of plasma D-dimer plus fibrinogen in predicting acute CVST. Int J Stroke. 2014 Feb; 9(2):166-73. PMID: 23506130; PMCID: PMC4144996.
  104. Lauer A, Pfeilschifter W, Schaffer CB, Lo EH, Foerch C. Intracerebral haemorrhage associated with antithrombotic treatment: translational insights from experimental studies. Lancet Neurol. 2013 Apr; 12(4):394-405. PMID: 23518332; PMCID: PMC3702044.
  105. Dapul HR, Park J, Zhang J, Lee C, DanEshmand A, Lok J, Ayata C, Gray T, Scalzo A, Qiu J, Lo EH, Whalen MJ. Concussive injury before or after controlled cortical impact exacerbates histopathology and functional outcome in a mixed traumatic brain injury model in mice. J Neurotrauma. 2013 Mar 01; 30(5):382-91. PMID: 23153355; PMCID: PMC3593692.
  106. Fan X, Lo EH, Wang X. Effects of minocycline plus tissue plasminogen activator combination therapy after focal embolic stroke in type 1 diabetic rats. Stroke. 2013 Mar; 44(3):745-52. PMID: 23422086; PMCID: PMC3632085.
  107. Foerch C, Rosidi NL, Schlunk F, Lauer A, Cianchetti FA, Mandeville E, Arai K, Yigitkanli K, Fan X, Wang X, van Leyen K, Steinmetz H, Schaffer CB, Lo EH. Intravenous tPA therapy does not worsen acute intracerebral hemorrhage in mice. PLoS One. 2013; 8(2):e54203. PMID: 23408937; PMCID: PMC3568130.
  108. Campos F, Qin T, Castillo J, Seo JH, Arai K, Lo EH, Waeber C. Fingolimod reduces hemorrhagic transformation associated with delayed tissue plasminogen activator treatment in a mouse thromboembolic model. Stroke. 2013 Feb; 44(2):505-11. PMID: 23287783; PMCID: PMC3586809.
  109. Seo JH, Miyamoto N, Hayakawa K, Pham LD, Maki T, Ayata C, Kim KW, Lo EH, Arai K. Oligodendrocyte precursors induce early blood-brain barrier opening after white matter injury. J Clin Invest. 2013 Feb; 123(2):782-6. PMID: 23281396; PMCID: PMC3561802.
  110. Hayakawa K, Pham LD, Arai K, Lo EH. High-mobility group box 1: an amplifier of stem and progenitor cell activity after stroke. Acta Neurochir Suppl. 2013; 118:31-8. PMID: 23564100; PMCID: PMC3985720.
  111. Cao J, Guo S, Arai K, Lo EH, Ning M. Studying extracellular signaling utilizing a glycoproteomic approach: lectin blot surveys, a first and important step. Methods Mol Biol. 2013; 1013:227-33. PMID: 23625503; PMCID: PMC3985769.
  112. Hayakawa K, Miyamoto N, Seo JH, Pham LD, Kim KW, Lo EH, Arai K. High-mobility group box 1 from reactive astrocytes enhances the accumulation of endothelial progenitor cells in damaged white matter. J Neurochem. 2013 Apr; 125(2):273-80. PMID: 23227954; PMCID: PMC3604050.
  113. Guo S, Zhou Y, Xing C, Lok J, Som AT, Ning M, Ji X, Lo EH. The vasculome of the mouse brain. PLoS One. 2012; 7(12):e52665. PMID: 23285140; PMCID: PMC3527566.
  114. Lopez MF, Sarracino DA, Vogelsang M, Sutton JN, Athanas M, Krastins B, Garces A, Prakash A, Peterman S, Demirjian Z, Inglessis-Azuaje I, Feeney K, Elia M, McMullin D, Dec GW, Palacios I, Lo EH, Buonanno F, Ning M. Heart-brain signaling in patent foramen ovale-related stroke: differential plasma proteomic expression patterns revealed with a 2-pass liquid chromatography-tandem mass spectrometry discovery workflow. J Investig Med. 2012 Dec; 60(8):1122-30. PMID: 23147404; PMCID: PMC3668452.
  115. Ning M, Lopez M, Cao J, Buonanno FS, Lo EH. Application of proteomics to cerebrovascular disease. Electrophoresis. 2012 Dec; 33(24):3582-97. PMID: 23161401; PMCID: PMC3712851.
  116. Yigitkanli K, Pekcec A, Karatas H, Pallast S, Mandeville E, Joshi N, Smirnova N, Gazaryan I, Ratan RR, Witztum JL, Montaner J, Holman TR, Lo EH, van Leyen K. Inhibition of 12/15-lipoxygenase as therapeutic strategy to treat stroke. Ann Neurol. 2013 Jan; 73(1):129-35. PMID: 23192915; PMCID: PMC3563836.
  117. Ahn BJ, Le H, Shin MW, Bae SJ, Lee EJ, Wee HJ, Cha JH, Park JH, Lee HS, Lee HJ, Jung H, Park ZY, Park SH, Han BW, Seo JH, Lo EH, Kim KW. The N-terminal ectodomain of Ninjurin1 liberated by MMP9 has chemotactic activity. Biochem Biophys Res Commun. 2012 Nov 30; 428(4):438-44. PMID: 23142597; PMCID: PMC3712845.
  118. Fan X, Ning M, Lo EH, Wang X. Early insulin glycemic control combined with tPA thrombolysis reduces acute brain tissue damages in a focal embolic stroke model of diabetic rats. Stroke. 2013 Jan; 44(1):255-9. PMID: 23117722; PMCID: PMC3600418.
  119. Guo S, Som AT, Waeber C, Lo EH. Vascular neuroprotection via TrkB- and Akt-dependent cell survival signaling. J Neurochem. 2012 Nov; 123 Suppl 2:58-64. PMID: 23050643; PMCID: PMC3503457.
  120. Pekcec A, Yigitkanli K, Jung JE, Pallast S, Xing C, Antipenko A, Minchenko M, Nikolov DB, Holman TR, Lo EH, van Leyen K. Following experimental stroke, the recovering brain is vulnerable to lipoxygenase-dependent semaphorin signaling. FASEB J. 2013 Feb; 27(2):437-45. PMID: 23070608; PMCID: PMC3545523.
  121. Meng R, Asmaro K, Meng L, Liu Y, Ma C, Xi C, Li G, Ren C, Luo Y, Ling F, Jia J, Hua Y, Wang X, Ding Y, Lo EH, Ji X. Upper limb ischemic preconditioning prevents recurrent stroke in intracranial arterial stenosis. Neurology. 2012 Oct 30; 79(18):1853-61. PMID: 23035060.
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  122. Chou SH, Feske SK, Atherton J, Konigsberg RG, De Jager PL, Du R, Ogilvy CS, Lo EH, Ning M. Early elevation of serum tumor necrosis factor-a is associated with poor outcome in subarachnoid hemorrhage. J Investig Med. 2012 Oct; 60(7):1054-8. PMID: 22918199; PMCID: PMC3740211.
  123. Goergen CJ, Radhakrishnan H, Sakadžic S, Mandeville ET, Lo EH, Sosnovik DE, Srinivasan VJ. Optical coherence tractography using intrinsic contrast. Opt Lett. 2012 Sep 15; 37(18):3882-4. PMID: 23041891; PMCID: PMC3691965.
  124. Tjärnlund-Wolf A, Brogren H, Lo EH, Wang X. Plasminogen activator inhibitor-1 and thrombotic cerebrovascular diseases. Stroke. 2012 Oct; 43(10):2833-9. PMID: 22879095; PMCID: PMC3712849.
  125. Cheung JS, Wang E, Lo EH, Sun PZ. Stratification of heterogeneous diffusion MRI ischemic lesion with kurtosis imaging: evaluation of mean diffusion and kurtosis MRI mismatch in an animal model of transient focal ischemia. Stroke. 2012 Aug; 43(8):2252-4. PMID: 22773558; PMCID: PMC3412055.
  126. Xing C, Arai K, Lo EH, Hommel M. Pathophysiologic cascades in ischemic stroke. Int J Stroke. 2012 Jul; 7(5):378-85. PMID: 22712739; PMCID: PMC3985770.
  127. Wu O, Lu J, Mandeville JB, Murata Y, Egi Y, Dai G, Marota JJ, Diwan I, Dijkhuizen RM, Kwong KK, Lo EH, Singhal AB. Dynamic functional cerebral blood volume responses to normobaric hyperoxia in acute ischemic stroke. J Cereb Blood Flow Metab. 2012 Sep; 32(9):1800-9. PMID: 22739619; PMCID: PMC3434635.
  128. Zhao S, Yu Z, Zhao G, Xing C, Hayakawa K, Whalen MJ, Lok JM, Lo EH, Wang X. Neuroglobin-overexpression reduces traumatic brain lesion size in mice. BMC Neurosci. 2012 Jun 15; 13:67. PMID: 22703519; PMCID: PMC3444402.
  129. Murata Y, Fujiwara N, Seo JH, Yan F, Liu X, Terasaki Y, Luo Y, Arai K, Ji X, Lo EH. Delayed inhibition of c-Jun N-terminal kinase worsens outcomes after focal cerebral ischemia. J Neurosci. 2012 Jun 13; 32(24):8112-5. PMID: 22699892; PMCID: PMC3752060.
  130. Xing C, Hayakawa K, Lok J, Arai K, Lo EH. Injury and repair in the neurovascular unit. Neurol Res. 2012 May; 34(4):325-30. PMID: 22643075; PMCID: PMC3985722.
  131. Hayakawa K, Pham LD, Katusic ZS, Arai K, Lo EH. Astrocytic high-mobility group box 1 promotes endothelial progenitor cell-mediated neurovascular remodeling during stroke recovery. Proc Natl Acad Sci U S A. 2012 May 08; 109(19):7505-10. PMID: 22529378; PMCID: PMC3358881.
  132. Lok J, Zhao S, Leung W, Seo JH, Navaratna D, Wang X, Whalen MJ, Lo EH. Neuregulin-1 effects on endothelial and blood-brain-barrier permeability after experimental injury. Transl Stroke Res. 2012 Jul; 3 Suppl 1:S119-24. PMID: 22773936; PMCID: PMC3389802.
  133. Xing C, Levchenko T, Guo S, Stins M, Torchilin VP, Lo EH. Delivering minocycline into brain endothelial cells with liposome-based technology. J Cereb Blood Flow Metab. 2012 Jun; 32(6):983-8. PMID: 22491155; PMCID: PMC3367232.
  134. Lopez MF, Sarracino DA, Prakash A, Athanas M, Krastins B, Rezai T, Sutton JN, Peterman S, Gvozdyak O, Chou S, Lo E, Buonanno F, Ning M. Discrimination of ischemic and hemorrhagic strokes using a multiplexed, mass spectrometry-based assay for serum apolipoproteins coupled to multi-marker ROC algorithm. Proteomics Clin Appl. 2012 Apr; 6(3-4):190-200. PMID: 22532455; PMCID: PMC3910141.
  135. Pham LD, Hayakawa K, Seo JH, Nguyen MN, Som AT, Lee BJ, Guo S, Kim KW, Lo EH, Arai K. Crosstalk between oligodendrocytes and cerebral endothelium contributes to vascular remodeling after white matter injury. Glia. 2012 May; 60(6):875-81. PMID: 22392631; PMCID: PMC3325331.
  136. Foerch C, You Z, Wang H, Lo EH, Whalen MJ. Traumatic brain injury during warfarin anticoagulation: an experimental study in mice. J Neurotrauma. 2012 Apr 10; 29(6):1150-5. PMID: 22142342.
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  137. Srinivasan VJ, Radhakrishnan H, Lo EH, Mandeville ET, Jiang JY, Barry S, Cable AE. OCT methods for capillary velocimetry. Biomed Opt Express. 2012 Mar 01; 3(3):612-29. PMID: 22435106; PMCID: PMC3296546.
  138. Hayakawa K, Seo JH, Pham LD, Miyamoto N, Som AT, Guo S, Kim KW, Lo EH, Arai K. Cerebral endothelial derived vascular endothelial growth factor promotes the migration but not the proliferation of oligodendrocyte precursor cells in vitro. Neurosci Lett. 2012 Mar 28; 513(1):42-6. PMID: 22342913; PMCID: PMC3302953.
  139. Simão F, Pagnussat AS, Seo JH, Navaratna D, Leung W, Lok J, Guo S, Waeber C, Salbego CG, Lo EH. Pro-angiogenic effects of resveratrol in brain endothelial cells: nitric oxide-mediated regulation of vascular endothelial growth factor and metalloproteinases. J Cereb Blood Flow Metab. 2012 May; 32(5):884-95. PMID: 22314268; PMCID: PMC3345913.
  140. Meng R, Konakondla S, Wang X, Lo EH, Ding Y, Ji X. Plasma biomarker may help to distinguish acute CVST from non-thrombotic CVSS in emergency. Int J Stroke. 2012 Feb; 7(2):183-4. PMID: 22264373; PMCID: PMC3985757.
  141. Lo EH. [Biphasic inflammatory responses in injury and repair after stroke]. Rinsho Shinkeigaku. 2012; 52(11):913. PMID: 23196465.
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  142. Seo JH, Guo S, Lok J, Navaratna D, Whalen MJ, Kim KW, Lo EH. Neurovascular matrix metalloproteinases and the blood-brain barrier. Curr Pharm Des. 2012; 18(25):3645-8. PMID: 22574977; PMCID: PMC3814178.
  143. Mbye LH, Keles E, Tao L, Zhang J, Chung J, Larvie M, Koppula R, Lo EH, Whalen MJ. Kollidon VA64, a membrane-resealing agent, reduces histopathology and improves functional outcome after controlled cortical impact in mice. J Cereb Blood Flow Metab. 2012 Mar; 32(3):515-24. PMID: 22086196; PMCID: PMC3293116.
  144. Zhu X, Tao L, Tejima-Mandeville E, Qiu J, Park J, Garber K, Ericsson M, Lo EH, Whalen MJ. Plasmalemma permeability and necrotic cell death phenotypes after intracerebral hemorrhage in mice. Stroke. 2012 Feb; 43(2):524-31. PMID: 22076006; PMCID: PMC4899048.
  145. Chou SH, Feske SK, Simmons SL, Konigsberg RG, Orzell SC, Marckmann A, Bourget G, Bauer DJ, De Jager PL, Du R, Arai K, Lo EH, Ning MM. Elevated peripheral neutrophils and matrix metalloproteinase 9 as biomarkers of functional outcome following subarachnoid hemorrhage. Transl Stroke Res. 2011 Dec; 2(4):600-7. PMID: 22207885.
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  146. Fan X, Qiu J, Yu Z, Dai H, Singhal AB, Lo EH, Wang X. A rat model of studying tissue-type plasminogen activator thrombolysis in ischemic stroke with diabetes. Stroke. 2012 Feb; 43(2):567-70. PMID: 22052516; PMCID: PMC3508716.
  147. Schlunk F, Van Cott EM, Hayakawa K, Pfeilschifter W, Lo EH, Foerch C. Recombinant activated coagulation factor VII and prothrombin complex concentrates are equally effective in reducing hematoma volume in experimental warfarin-associated intracerebral hemorrhage. Stroke. 2012 Jan; 43(1):246-9. PMID: 21998055; PMCID: PMC3722613.
  148. Ding MC, Wang Q, Lo EH, Stanley GB. Cortical excitation and inhibition following focal traumatic brain injury. J Neurosci. 2011 Oct 05; 31(40):14085-94. PMID: 21976493; PMCID: PMC3444158.
  149. Wei X, Yu Z, Cho KS, Chen H, Malik MT, Chen X, Lo EH, Wang X, Chen DF. Neuroglobin is an endogenous neuroprotectant for retinal ganglion cells against glaucomatous damage. Am J Pathol. 2011 Dec; 179(6):2788-97. PMID: 21967817; PMCID: PMC3260831.
  150. Chou SH, Lee PS, Konigsberg RG, Gallacci D, Chiou T, Arai K, Simmons S, Bauer D, Feske SK, Lo EH, Ning M. Plasma-type gelsolin is decreased in human blood and cerebrospinal fluid after subarachnoid hemorrhage. Stroke. 2011 Dec; 42(12):3624-7. PMID: 21940962; PMCID: PMC3537515.
  151. Park J, Zhang J, Qiu J, Zhu X, Degterev A, Lo EH, Whalen MJ. Combination therapy targeting Akt and mammalian target of rapamycin improves functional outcome after controlled cortical impact in mice. J Cereb Blood Flow Metab. 2012 Feb; 32(2):330-40. PMID: 21934697; PMCID: PMC3272599.
  152. Lauer A, Cianchetti FA, Van Cott EM, Schlunk F, Schulz E, Pfeilschifter W, Steinmetz H, Schaffer CB, Lo EH, Foerch C. Anticoagulation with the oral direct thrombin inhibitor dabigatran does not enlarge hematoma volume in experimental intracerebral hemorrhage. Circulation. 2011 Oct 11; 124(15):1654-62. PMID: 21911784; PMCID: PMC3724228.
  153. Hayakawa K, Pham LD, Som AT, Lee BJ, Guo S, Lo EH, Arai K. Vascular endothelial growth factor regulates the migration of oligodendrocyte precursor cells. J Neurosci. 2011 Jul 20; 31(29):10666-70. PMID: 21775609; PMCID: PMC3145205.
  154. Cheung JS, Wang E, Zhang X, Mandeville E, Lo EH, Sorensen AG, Sun PZ. Fast radio-frequency enforced steady state (FRESS) spin echo MRI for quantitative T2 mapping: minimizing the apparent repetition time (TR) dependence for fast T2 measurement. NMR Biomed. 2012 Feb; 25(2):189-94. PMID: 21755552; PMCID: PMC3712835.
  155. Kahle KT, Walcott BP, Nahed BV, Barnard ZR, Lo EH, Buonanno FS, Venna N, Ning M. Cerebral edema and a transtentorial brain herniation syndrome associated with pandemic swine influenza A (H1N1) virus infection. J Clin Neurosci. 2011 Sep; 18(9):1245-8. PMID: 21742505; PMCID: PMC3705580.
  156. Lok J, Leung W, Zhao S, Pallast S, van Leyen K, Guo S, Wang X, Yalcin A, Lo EH. ?-glutamylcysteine ethyl ester protects cerebral endothelial cells during injury and decreases blood-brain barrier permeability after experimental brain trauma. J Neurochem. 2011 Jul; 118(2):248-55. PMID: 21534958; PMCID: PMC3285992.
  157. Arai K, Lok J, Guo S, Hayakawa K, Xing C, Lo EH. Cellular mechanisms of neurovascular damage and repair after stroke. J Child Neurol. 2011 Sep; 26(9):1193-8. PMID: 21628695; PMCID: PMC3530192.
  158. Navaratna D, Guo SZ, Hayakawa K, Wang X, Gerhardinger C, Lo EH. Decreased cerebrovascular brain-derived neurotrophic factor-mediated neuroprotection in the diabetic brain. Diabetes. 2011 Jun; 60(6):1789-96. PMID: 21562076; PMCID: PMC3114398.
  159. Caplan LR, Arenillas J, Cramer SC, Joutel A, Lo EH, Meschia J, Savitz S, Tournier-Lasserve E. Stroke-related translational research. Arch Neurol. 2011 Sep; 68(9):1110-23. PMID: 21555605; PMCID: PMC3691989.
  160. Sakadžic S, Roussakis E, Yaseen MA, Mandeville ET, Srinivasan VJ, Arai K, Ruvinskaya S, Wu W, Devor A, Lo EH, Vinogradov SA, Boas DA. Cerebral blood oxygenation measurement based on oxygen-dependent quenching of phosphorescence. J Vis Exp. 2011 May 04; (51). PMID: 21587157; PMCID: PMC3197095.
  161. Fujiwara N, Mandeville ET, Geng X, Luo Y, Arai K, Wang X, Ji X, Singhal AB, Lo EH. Effect of normobaric oxygen therapy in a rat model of intracerebral hemorrhage. Stroke. 2011 May; 42(5):1469-72. PMID: 21415401.
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  162. Sun PZ, Cheung JS, Wang E, Lo EH. Association between pH-weighted endogenous amide proton chemical exchange saturation transfer MRI and tissue lactic acidosis during acute ischemic stroke. J Cereb Blood Flow Metab. 2011 Aug; 31(8):1743-50. PMID: 21386856; PMCID: PMC3170940.
  163. Lauer A, Schlunk F, Van Cott EM, Steinmetz H, Lo EH, Foerch C. Antiplatelet pretreatment does not increase hematoma volume in experimental intracerebral hemorrhage. J Cereb Blood Flow Metab. 2011 Aug; 31(8):1736-42. PMID: 21386857; PMCID: PMC3170939.
  164. Walvick RP, Bråtane BT, Henninger N, Sicard KM, Bouley J, Yu Z, Lo E, Wang X, Fisher M. Visualization of clot lysis in a rat embolic stroke model: application to comparative lytic efficacy. Stroke. 2011 Apr; 42(4):1110-5. PMID: 21372305; PMCID: PMC3094728.
  165. Ning M, Lo EH. Erratum: opportunities and challenges in omics. Transl Stroke Res. 2011 Mar; 2(1):128. PMID: 24323589.
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  166. Lok J, Leung W, Murphy S, Butler W, Noviski N, Lo EH. Intracranial hemorrhage: mechanisms of secondary brain injury. Acta Neurochir Suppl. 2011; 111:63-9. PMID: 21725733; PMCID: PMC3285293.
  167. Ning M, Sarracino DA, Kho AT, Guo S, Lee SR, Krastins B, Buonanno FS, Vizcaíno JA, Orchard S, McMullin D, Wang X, Lo EH. Proteomic temporal profile of human brain endothelium after oxidative stress. Stroke. 2011 Jan; 42(1):37-43. PMID: 21164131; PMCID: PMC3696517.
  168. Ning M, Lo EH. Opportunities and challenges in omics. Transl Stroke Res. 2010 Dec 01; 1(4):233-7. PMID: 22140416.
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  169. Ning M, Sarracino DA, Buonanno FS, Krastins B, Chou S, McMullin D, Wang X, Lopez M, Lo EH. Proteomic Protease Substrate Profiling of tPA Treatment in Acute Ischemic Stroke Patients: A Step Toward Individualizing Thrombolytic Therapy at the Bedside. Transl Stroke Res. 2010 Dec 01; 1(4):268-75. PMID: 22140417.
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  170. Wei Y, Yemisci M, Kim HH, Yung LM, Shin HK, Hwang SK, Guo S, Qin T, Alsharif N, Brinkmann V, Liao JK, Lo EH, Waeber C. Fingolimod provides long-term protection in rodent models of cerebral ischemia. Ann Neurol. 2011 Jan; 69(1):119-29. PMID: 21280082; PMCID: PMC3200194.
  171. Khuman J, Meehan WP, Zhu X, Qiu J, Hoffmann U, Zhang J, Giovannone E, Lo EH, Whalen MJ. Tumor necrosis factor alpha and Fas receptor contribute to cognitive deficits independent of cell death after concussive traumatic brain injury in mice. J Cereb Blood Flow Metab. 2011 Feb; 31(2):778-89. PMID: 20940727; PMCID: PMC3049532.
  172. Hayakawa K, Qiu J, Lo EH. Biphasic actions of HMGB1 signaling in inflammation and recovery after stroke. Ann N Y Acad Sci. 2010 Oct; 1207:50-7. PMID: 20955426; PMCID: PMC3705575.
  173. Fan X, Yu Z, Liu J, Liu N, Hajjar KA, Furie KL, Lo EH, Wang X. Annexin A2: a tissue plasminogen activator amplifier for thrombolytic stroke therapy. Stroke. 2010 Oct; 41(10 Suppl):S54-8. PMID: 20876506; PMCID: PMC2994255.
  174. Lo EH. Degeneration and repair in central nervous system disease. Nat Med. 2010 Nov; 16(11):1205-9. PMID: 21052074; PMCID: PMC3985732.
  175. Sakadzic S, Roussakis E, Yaseen MA, Mandeville ET, Srinivasan VJ, Arai K, Ruvinskaya S, Devor A, Lo EH, Vinogradov SA, Boas DA. Two-photon high-resolution measurement of partial pressure of oxygen in cerebral vasculature and tissue. Nat Methods. 2010 Sep; 7(9):755-9. PMID: 20693997; PMCID: PMC2932799.
  176. Hachinski V, Donnan GA, Gorelick PB, Hacke W, Cramer SC, Kaste M, Fisher M, Brainin M, Buchan AM, Lo EH, Skolnick BE, Furie KL, Hankey GJ, Kivipelto M, Morris J, Rothwell PM, Sacco RL, Smith SC, Wang Y, Bryer A, Ford GA, Iadecola C, Martins SC, Saver J, Skvortsova V, Bayley M, Bednar MM, Duncan P, Enney L, Finklestein S, Jones TA, Kalra L, Kleim J, Nitkin R, Teasell R, Weiller C, Desai B, Goldberg MP, Heiss WD, Saarelma O, Schwamm LH, Shinohara Y, Trivedi B, Wahlgren N, Wong LK, Hakim A, Norrving B, Prudhomme S, Bornstein NM, Davis SM, Goldstein LB, Leys D, Tuomilehto J. Stroke: working toward a prioritized world agenda. Int J Stroke. 2010 Aug; 5(4):238-56. PMID: 20636706; PMCID: PMC3712839.
  177. Moskowitz MA, Lo EH, Iadecola C. The science of stroke: mechanisms in search of treatments. Neuron. 2010 Jul 29; 67(2):181-98. PMID: 20670828; PMCID: PMC2957363.
  178. Qiu J, Xu J, Zheng Y, Wei Y, Zhu X, Lo EH, Moskowitz MA, Sims JR. High-mobility group box 1 promotes metalloproteinase-9 upregulation through Toll-like receptor 4 after cerebral ischemia. Stroke. 2010 Sep; 41(9):2077-82. PMID: 20671243; PMCID: PMC3066477.
  179. Guo S, Stins M, Ning M, Lo EH. Amelioration of inflammation and cytotoxicity by dipyridamole in brain endothelial cells. Cerebrovasc Dis. 2010 Aug; 30(3):290-6. PMID: 20664263; PMCID: PMC3214842.
  180. Freedman OC, Dodge J, Shaw P, Oza AM, Bernadini M, Klachook S, Murphy KJ, Lo E, Rosen B, Mackay H. Diagnosis of epithelial ovarian carcinoma prior to neoadjuvant chemotherapy. Gynecol Oncol. 2010 Oct; 119(1):22-5. PMID: 20591472.
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  181. Hachinski V, Donnan GA, Gorelick PB, Hacke W, Cramer SC, Kaste M, Fisher M, Brainin M, Buchan AM, Lo EH, Skolnick BE, Furie KL, Hankey GJ, Kivipelto M, Morris J, Rothwell PM, Sacco RL, Smith SC, Wang Y, Bryer A, Ford GA, Iadecola C, Martins SC, Saver J, Skvortsova V, Bayley M, Bednar MM, Duncan P, Enney L, Finklestein S, Jones TA, Kalra L, Kleim J, Nitkin R, Teasell R, Weiller C, Desai B, Goldberg MP, Heiss WD, Saarelma O, Schwamm LH, Shinohara Y, Trivedi B, Wahlgren N, Wong LK, Hakim A, Norrving B, Prudhomme S, Bornstein NM, Davis SM, Goldstein LB, Leys D, Tuomilehto J. Stroke: working toward a prioritized world agenda. Stroke. 2010 Jun; 41(6):1084-99. PMID: 20498453; PMCID: PMC3712843.
  182. Hayakawa K, Arai K, Lo EH. Role of ERK map kinase and CRM1 in IL-1beta-stimulated release of HMGB1 from cortical astrocytes. Glia. 2010 Jun; 58(8):1007-15. PMID: 20222144; PMCID: PMC3814180.
  183. Yang J, You Z, Kim HH, Hwang SK, Khuman J, Guo S, Lo EH, Whalen MJ. Genetic analysis of the role of tumor necrosis factor receptors in functional outcome after traumatic brain injury in mice. J Neurotrauma. 2010 Jun; 27(6):1037-46. PMID: 20205514; PMCID: PMC2943499.
  184. Hachinski V, Donnan GA, Gorelick PB, Hacke W, Cramer SC, Kaste M, Fisher M, Brainin M, Buchan AM, Lo EH, Skolnick BE, Furie KL, Hankey GJ, Kivipelto M, Morris J, Rothwell PM, Sacco RL, Smith SC, Wang Y, Bryer A, Ford GA, Iadecola C, Martins SC, Saver J, Skvortsova V, Bayley M, Bednar MM, Duncan P, Enney L, Finklestein S, Jones TA, Kalra L, Kleim J, Nitkin R, Teasell R, Weiller C, Desai B, Goldberg MP, Heiss WD, Saarelma O, Schwamm LH, Shinohara Y, Trivedi B, Wahlgren N, Wong LK, Hakim A, Norrving B, Prudhomme S, Bornstein NM, Davis SM, Goldstein LB, Leys D, Tuomilehto J. Stroke: working toward a prioritized world agenda. Cerebrovasc Dis. 2010; 30(2):127-47. PMID: 20516682; PMCID: PMC3221270.
  185. Xing C, Arai K, Park KP, Lo EH. Induction of vascular endothelial growth factor and matrix metalloproteinase-9 via CD47 signaling in neurovascular cells. Neurochem Res. 2010 Jul; 35(7):1092-7. PMID: 20364320; PMCID: PMC3985723.
  186. Arai K, Lo EH. Astrocytes protect oligodendrocyte precursor cells via MEK/ERK and PI3K/Akt signaling. J Neurosci Res. 2010 Mar; 88(4):758-63. PMID: 19830833; PMCID: PMC3705578.
  187. Jin G, Sun PZ, Singhal AB, Ayata C, Lo EH. First-order mathematical modeling of brain swelling in focal cerebral ischemia. Transl Stroke Res. 2010 Mar; 1(1):65-70. PMID: 24323451.
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  188. Zhu H, Fan X, Yu Z, Liu J, Murata Y, Lu J, Zhao S, Hajjar KA, Lo EH, Wang X. Annexin A2 combined with low-dose tPA improves thrombolytic therapy in a rat model of focal embolic stroke. J Cereb Blood Flow Metab. 2010 Jun; 30(6):1137-46. PMID: 20068577; PMCID: PMC2949213.
  189. Pallast S, Arai K, Pekcec A, Yigitkanli K, Yu Z, Wang X, Lo EH, van Leyen K. Increased nuclear apoptosis-inducing factor after transient focal ischemia: a 12/15-lipoxygenase-dependent organelle damage pathway. J Cereb Blood Flow Metab. 2010 Jun; 30(6):1157-67. PMID: 20068575; PMCID: PMC2915762.
  190. Hayakawa K, Nakano T, Irie K, Higuchi S, Fujioka M, Orito K, Iwasaki K, Jin G, Lo EH, Mishima K, Fujiwara M. Inhibition of reactive astrocytes with fluorocitrate retards neurovascular remodeling and recovery after focal cerebral ischemia in mice. J Cereb Blood Flow Metab. 2010 Apr; 30(4):871-82. PMID: 19997116; PMCID: PMC2949171.
  191. Tejima E, Guo S, Murata Y, Arai K, Lok J, van Leyen K, Rosell A, Wang X, Lo EH. Neuroprotective effects of overexpressing tissue inhibitor of metalloproteinase TIMP-1. J Neurotrauma. 2009 Nov; 26(11):1935-41. PMID: 19469687; PMCID: PMC2822804.
  192. Arai K, Lo EH. Experimental models for analysis of oligodendrocyte pathophysiology in stroke. Exp Transl Stroke Med. 2009 Oct 24; 1:6. PMID: 20150984; PMCID: PMC2820444.
  193. Lee BJ, Egi Y, van Leyen K, Lo EH, Arai K. Edaravone, a free radical scavenger, protects components of the neurovascular unit against oxidative stress in vitro. Brain Res. 2010 Jan 11; 1307:22-7. PMID: 19840779; PMCID: PMC2797401.
  194. Arai K, Lo EH. Oligovascular signaling in white matter stroke. Biol Pharm Bull. 2009 Oct; 32(10):1639-44. PMID: 19801821; PMCID: PMC3691964.
  195. Pallast S, Arai K, Wang X, Lo EH, van Leyen K. 12/15-Lipoxygenase targets neuronal mitochondria under oxidative stress. J Neurochem. 2009 Nov; 111(3):882-9. PMID: 19737346; PMCID: PMC2773137.
  196. Xing C, Lee S, Kim WJ, Wang H, Yang YG, Ning M, Wang X, Lo EH. Neurovascular effects of CD47 signaling: promotion of cell death, inflammation, and suppression of angiogenesis in brain endothelial cells in vitro. J Neurosci Res. 2009 Aug 15; 87(11):2571-7. PMID: 19360900; PMCID: PMC3712846.
  197. Foerch C, Montaner J, Furie KL, Ning MM, Lo EH. Invited article: searching for oracles? Blood biomarkers in acute stroke. Neurology. 2009 Aug 04; 73(5):393-9. PMID: 19652144; PMCID: PMC2725929.
  198. Lo EH. T time in the brain. Nat Med. 2009 Aug; 15(8):844-6. PMID: 19661986.
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  199. Arai K, Jin G, Navaratna D, Lo EH. Brain angiogenesis in developmental and pathological processes: neurovascular injury and angiogenic recovery after stroke. FEBS J. 2009 Sep; 276(17):4644-52. PMID: 19664070; PMCID: PMC3712842.
  200. Hotokezaka Y, van Leyen K, Lo EH, Beatrix B, Katayama I, Jin G, Nakamura T. alphaNAC depletion as an initiator of ER stress-induced apoptosis in hypoxia. Cell Death Differ. 2009 Nov; 16(11):1505-14. PMID: 19609276.
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  201. Fujiwara N, Murata Y, Arai K, Egi Y, Lu J, Wu O, Singhal AB, Lo EH. Combination therapy with normobaric oxygen (NBO) plus thrombolysis in experimental ischemic stroke. BMC Neurosci. 2009 Jul 15; 10:79. PMID: 19604385; PMCID: PMC2714858.
  202. Park KP, Rosell A, Foerch C, Xing C, Kim WJ, Lee S, Opdenakker G, Furie KL, Lo EH. Plasma and brain matrix metalloproteinase-9 after acute focal cerebral ischemia in rats. Stroke. 2009 Aug; 40(8):2836-42. PMID: 19556529; PMCID: PMC3712850.
  203. Ji RR, Xu ZZ, Wang X, Lo EH. Matrix metalloprotease regulation of neuropathic pain. Trends Pharmacol Sci. 2009 Jul; 30(7):336-40. PMID: 19523695; PMCID: PMC2706286.
  204. Yu Z, Liu J, Guo S, Xing C, Fan X, Ning M, Yuan JC, Lo EH, Wang X. Neuroglobin-overexpression alters hypoxic response gene expression in primary neuron culture following oxygen glucose deprivation. Neuroscience. 2009 Aug 18; 162(2):396-403. PMID: 19401220; PMCID: PMC2787411.
  205. Navaratna D, Guo S, Arai K, Lo EH. Mechanisms and targets for angiogenic therapy after stroke. Cell Adh Migr. 2009 Apr-Jun; 3(2):216-23. PMID: 19363301; PMCID: PMC2679890.
  206. Arai K, Lo EH. An oligovascular niche: cerebral endothelial cells promote the survival and proliferation of oligodendrocyte precursor cells. J Neurosci. 2009 Apr 08; 29(14):4351-5. PMID: 19357263; PMCID: PMC3849498.
  207. Foerch C, Arai K, Van Cott EM, van Leyen K, Lo EH. Rapid reversal of anticoagulation reduces hemorrhage volume in a mouse model of warfarin-associated intracerebral hemorrhage. J Cereb Blood Flow Metab. 2009 May; 29(5):1015-21. PMID: 19319147; PMCID: PMC3691988.
  208. Yu Z, Fan X, Lo EH, Wang X. Neuroprotective roles and mechanisms of neuroglobin. Neurol Res. 2009 Mar; 31(2):122-7. PMID: 19298751; PMCID: PMC3712852.
  209. Fisher M, Feuerstein G, Howells DW, Hurn PD, Kent TA, Savitz SI, Lo EH. Update of the stroke therapy academic industry roundtable preclinical recommendations. Stroke. 2009 Jun; 40(6):2244-50. PMID: 19246690; PMCID: PMC2888275.
  210. Rosell A, Arai K, Lok J, He T, Guo S, Navarro M, Montaner J, Katusic ZS, Lo EH. Interleukin-1beta augments angiogenic responses of murine endothelial progenitor cells in vitro. J Cereb Blood Flow Metab. 2009 May; 29(5):933-43. PMID: 19240740; PMCID: PMC3712840.
  211. Jin G, Tsuji K, Xing C, Yang YG, Wang X, Lo EH. CD47 gene knockout protects against transient focal cerebral ischemia in mice. Exp Neurol. 2009 May; 217(1):165-70. PMID: 19233173; PMCID: PMC3722607.
  212. Park JW, Jang YH, Kim JM, Lee H, Park WK, Lim MB, Chu YK, Lo EH, Lee SR. Green tea polyphenol (-)-epigallocatechin gallate reduces neuronal cell damage and up-regulation of MMP-9 activity in hippocampal CA1 and CA2 areas following transient global cerebral ischemia. J Neurosci Res. 2009 Feb; 87(2):567-75. PMID: 18752302.
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  213. Lee H, Park JW, Kim SP, Lo EH, Lee SR. Doxycycline inhibits matrix metalloproteinase-9 and laminin degradation after transient global cerebral ischemia. Neurobiol Dis. 2009 May; 34(2):189-98. PMID: 19200854.
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  214. Liu J, Yu Z, Guo S, Lee SR, Xing C, Zhang C, Gao Y, Nicholls DG, Lo EH, Wang X. Effects of neuroglobin overexpression on mitochondrial function and oxidative stress following hypoxia/reoxygenation in cultured neurons. J Neurosci Res. 2009 Jan; 87(1):164-70. PMID: 18711728; PMCID: PMC2631383.
  215. Ning M, Wang X, Lo EH. Reperfusion injury after stroke: neurovascular proteases and the blood-brain barrier. Handb Clin Neurol. 2009; 92:117-36. PMID: 18790272.
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  216. Devor A, Hillman EM, Tian P, Waeber C, Teng IC, Ruvinskaya L, Shalinsky MH, Zhu H, Haslinger RH, Narayanan SN, Ulbert I, Dunn AK, Lo EH, Rosen BR, Dale AM, Kleinfeld D, Boas DA. Stimulus-induced changes in blood flow and 2-deoxyglucose uptake dissociate in ipsilateral somatosensory cortex. J Neurosci. 2008 Dec 31; 28(53):14347-57. PMID: 19118167; PMCID: PMC2655308.
  217. Lu J, Dai G, Egi Y, Huang S, Kwon SJ, Lo EH, Kim YR. Characterization of cerebrovascular responses to hyperoxia and hypercapnia using MRI in rat. Neuroimage. 2009 May 01; 45(4):1126-34. PMID: 19118633.
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  218. Lo EH, Rosenberg GA. The neurovascular unit in health and disease: introduction. Stroke. 2009 Mar; 40(3 Suppl):S2-3. PMID: 19064779; PMCID: PMC2811575.
  219. Guo S, Lo EH. Dysfunctional cell-cell signaling in the neurovascular unit as a paradigm for central nervous system disease. Stroke. 2009 Mar; 40(3 Suppl):S4-7. PMID: 19064781; PMCID: PMC3712844.
  220. Xing C, Lee S, Kim WJ, Jin G, Yang YG, Ji X, Wang X, Lo EH. Role of oxidative stress and caspase 3 in CD47-mediated neuronal cell death. J Neurochem. 2009 Jan; 108(2):430-6. PMID: 19012741; PMCID: PMC3705576.
  221. Guo S, Arai K, Stins MF, Chuang DM, Lo EH. Lithium upregulates vascular endothelial growth factor in brain endothelial cells and astrocytes. Stroke. 2009 Feb; 40(2):652-5. PMID: 18974377; PMCID: PMC3691992.
  222. Murata Y, Rosell A, Scannevin RH, Rhodes KJ, Wang X, Lo EH. Extension of the thrombolytic time window with minocycline in experimental stroke. Stroke. 2008 Dec; 39(12):3372-7. PMID: 18927459; PMCID: PMC3705574.
  223. Kim YR, Tejima E, Huang S, Atochin DN, Dai G, Lo EH, Huang PL, Bogdanov A, Rosen BR. In vivo quantification of transvascular water exchange during the acute phase of permanent stroke. Magn Reson Med. 2008 Oct; 60(4):813-21. PMID: 18816832; PMCID: PMC2727619.
  224. Foerch C, Arai K, Jin G, Park KP, Pallast S, van Leyen K, Lo EH. Experimental model of warfarin-associated intracerebral hemorrhage. Stroke. 2008 Dec; 39(12):3397-404. PMID: 18772448; PMCID: PMC3712841.
  225. Lok J, Sardi SP, Guo S, Besancon E, Ha DM, Rosell A, Kim WJ, Corfas G, Lo EH. Neuregulin-1 signaling in brain endothelial cells. J Cereb Blood Flow Metab. 2009 Jan; 29(1):39-43. PMID: 18728681; PMCID: PMC3680122.
  226. Jin G, Arai K, Murata Y, Wang S, Stins MF, Lo EH, van Leyen K. Protecting against cerebrovascular injury: contributions of 12/15-lipoxygenase to edema formation after transient focal ischemia. Stroke. 2008 Sep; 39(9):2538-43. PMID: 18635843; PMCID: PMC2754072.
  227. Wang X, Rosell A, Lo EH. Targeting extracellular matrix proteolysis for hemorrhagic complications of tPA stroke therapy. CNS Neurol Disord Drug Targets. 2008 Jun; 7(3):235-42. PMID: 18673208.
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  228. Guo S, Kim WJ, Lok J, Lee SR, Besancon E, Luo BH, Stins MF, Wang X, Dedhar S, Lo EH. Neuroprotection via matrix-trophic coupling between cerebral endothelial cells and neurons. Proc Natl Acad Sci U S A. 2008 May 27; 105(21):7582-7. PMID: 18495934; PMCID: PMC2396701.
  229. Lo EH. A new penumbra: transitioning from injury into repair after stroke. Nat Med. 2008 May; 14(5):497-500. PMID: 18463660.
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  230. Sun PZ, Murata Y, Lu J, Wang X, Lo EH, Sorensen AG. Relaxation-compensated fast multislice amide proton transfer (APT) imaging of acute ischemic stroke. Magn Reson Med. 2008 May; 59(5):1175-82. PMID: 18429031.
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  231. Ding MC, Lo EH, Stanley GB. Sustained focal cortical compression reduces electrically-induced seizure threshold. Neuroscience. 2008 Jun 23; 154(2):551-5. PMID: 18495350; PMCID: PMC2475585.
  232. Wang X, Liu J, Zhu H, Tejima E, Tsuji K, Murata Y, Atochin DN, Huang PL, Zhang C, Lo EH. Effects of neuroglobin overexpression on acute brain injury and long-term outcomes after focal cerebral ischemia. Stroke. 2008 Jun; 39(6):1869-74. PMID: 18403737; PMCID: PMC2727360.
  233. Besancon E, Guo S, Lok J, Tymianski M, Lo EH. Beyond NMDA and AMPA glutamate receptors: emerging mechanisms for ionic imbalance and cell death in stroke. Trends Pharmacol Sci. 2008 May; 29(5):268-75. PMID: 18384889.
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  234. Rosell A, Cuadrado E, Ortega-Aznar A, Hernández-Guillamon M, Lo EH, Montaner J. MMP-9-positive neutrophil infiltration is associated to blood-brain barrier breakdown and basal lamina type IV collagen degradation during hemorrhagic transformation after human ischemic stroke. Stroke. 2008 Apr; 39(4):1121-6. PMID: 18323498.
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  235. van Leyen K, Arai K, Jin G, Kenyon V, Gerstner B, Rosenberg PA, Holman TR, Lo EH. Novel lipoxygenase inhibitors as neuroprotective reagents. J Neurosci Res. 2008 Mar; 86(4):904-9. PMID: 17960827; PMCID: PMC2759176.
  236. Kawasaki Y, Xu ZZ, Wang X, Park JY, Zhuang ZY, Tan PH, Gao YJ, Roy K, Corfas G, Lo EH, Ji RR. Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain. Nat Med. 2008 Mar; 14(3):331-6. PMID: 18264108; PMCID: PMC2279180.
  237. Rosell A, Lo EH. Multiphasic roles for matrix metalloproteinases after stroke. Curr Opin Pharmacol. 2008 Feb; 8(1):82-9. PMID: 18226583.
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  238. Kim YR, van Meer MP, Tejima E, Murata Y, Mandeville JB, Dai G, Chuang DM, Rosen BR, Lo EH. Functional MRI of delayed chronic lithium treatment in rat focal cerebral ischemia. Stroke. 2008 Feb; 39(2):439-47. PMID: 18187690; PMCID: PMC3712848.
  239. Singhal AB, Lo EH. Advances in emerging nondrug therapies for acute stroke 2007. Stroke. 2008 Feb; 39(2):289-91. PMID: 18187678; PMCID: PMC3705573.
  240. Rosell A, Foerch C, Murata Y, Lo EH. Mechanisms and markers for hemorrhagic transformation after stroke. Acta Neurochir Suppl. 2008; 105:173-8. PMID: 19066105.
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  241. Lo EH. Experimental models, neurovascular mechanisms and translational issues in stroke research. Br J Pharmacol. 2008 Mar; 153 Suppl 1:S396-405. PMID: 18157168; PMCID: PMC2268069.
  242. Kelly PJ, Morrow JD, Ning M, Koroshetz W, Lo EH, Terry E, Milne GL, Hubbard J, Lee H, Stevenson E, Lederer M, Furie KL. Oxidative stress and matrix metalloproteinase-9 in acute ischemic stroke: the Biomarker Evaluation for Antioxidant Therapies in Stroke (BEAT-Stroke) study. Stroke. 2008 Jan; 39(1):100-4. PMID: 18063832.
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  243. Lok J, Wang H, Murata Y, Zhu HH, Qin T, Whalen MJ, Lo EH. Effect of neuregulin-1 on histopathological and functional outcome after controlled cortical impact in mice. J Neurotrauma. 2007 Dec; 24(12):1817-22. PMID: 18159993.
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  244. Lee SR, Lok J, Rosell A, Kim HY, Murata Y, Atochin D, Huang PL, Wang X, Ayata C, Moskowitz MA, Lo EH. Reduction of hippocampal cell death and proteolytic responses in tissue plasminogen activator knockout mice after transient global cerebral ischemia. Neuroscience. 2007 Nov 30; 150(1):50-7. PMID: 17936515; PMCID: PMC3814181.
  245. Whalen MJ, Dalkara T, You Z, Qiu J, Bermpohl D, Mehta N, Suter B, Bhide PG, Lo EH, Ericsson M, Moskowitz MA. Acute plasmalemma permeability and protracted clearance of injured cells after controlled cortical impact in mice. J Cereb Blood Flow Metab. 2008 Mar; 28(3):490-505. PMID: 17713463; PMCID: PMC2711980.
  246. Shin HK, Dunn AK, Jones PB, Boas DA, Lo EH, Moskowitz MA, Ayata C. Normobaric hyperoxia improves cerebral blood flow and oxygenation, and inhibits peri-infarct depolarizations in experimental focal ischaemia. Brain. 2007 Jun; 130(Pt 6):1631-42. PMID: 17468117; PMCID: PMC3023418.
  247. Lok J, Gupta P, Guo S, Kim WJ, Whalen MJ, van Leyen K, Lo EH. Cell-cell signaling in the neurovascular unit. Neurochem Res. 2007 Dec; 32(12):2032-45. PMID: 17457674.
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  248. Bermpohl D, You Z, Lo EH, Kim HH, Whalen MJ. TNF alpha and Fas mediate tissue damage and functional outcome after traumatic brain injury in mice. J Cereb Blood Flow Metab. 2007 Nov; 27(11):1806-18. PMID: 17406655.
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  249. Zhao BQ, Tejima E, Lo EH. Neurovascular proteases in brain injury, hemorrhage and remodeling after stroke. Stroke. 2007 Feb; 38(2 Suppl):748-52. PMID: 17261731.
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  250. Lee SR, Guo SZ, Scannevin RH, Magliaro BC, Rhodes KJ, Wang X, Lo EH. Induction of matrix metalloproteinase, cytokines and chemokines in rat cortical astrocytes exposed to plasminogen activators. Neurosci Lett. 2007 Apr 24; 417(1):1-5. PMID: 17386975.
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  251. Kim DE, Tsuji K, Kim YR, Mueller FJ, Eom HS, Snyder EY, Lo EH, Weissleder R, Schellingerhout D. Neural stem cell transplant survival in brains of mice: assessing the effect of immunity and ischemia by using real-time bioluminescent imaging. Radiology. 2006 Dec; 241(3):822-30. PMID: 17114629.
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  252. van Leyen K, Kim HY, Lee SR, Jin G, Arai K, Lo EH. Baicalein and 12/15-lipoxygenase in the ischemic brain. Stroke. 2006 Dec; 37(12):3014-8. PMID: 17053180.
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  253. Guo S, Wang S, Kim WJ, Lee SR, Frosch MP, Bacskai BJ, Greenberg SM, Lo EH. Effects of apoE isoforms on beta-amyloid-induced matrix metalloproteinase-9 in rat astrocytes. Brain Res. 2006 Sep 21; 1111(1):222-6. PMID: 16919608.
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  254. Tejima E, Zhao BQ, Tsuji K, Rosell A, van Leyen K, Gonzalez RG, Montaner J, Wang X, Lo EH. Astrocytic induction of matrix metalloproteinase-9 and edema in brain hemorrhage. J Cereb Blood Flow Metab. 2007 Mar; 27(3):460-8. PMID: 16788715.
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  255. Wang S, Lee SR, Guo SZ, Kim WJ, Montaner J, Wang X, Lo EH. Reduction of tissue plasminogen activator-induced matrix metalloproteinase-9 by simvastatin in astrocytes. Stroke. 2006 Jul; 37(7):1910-2. PMID: 16741180.
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  256. Ning M, Furie KL, Koroshetz WJ, Lee H, Barron M, Lederer M, Wang X, Zhu M, Sorensen AG, Lo EH, Kelly PJ. Association between tPA therapy and raised early matrix metalloproteinase-9 in acute stroke. Neurology. 2006 May 23; 66(10):1550-5. PMID: 16717217.
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  257. Kim YR, van Meer MP, Mandeville JB, Tejima E, Dai G, Topalkara K, Qui J, Dijkhuizen RM, Moskowitz MA, Lo EH, Rosen BR. fMRI of delayed albumin treatment during stroke recovery in rats: implication for fast neuronal habituation in recovering brains. J Cereb Blood Flow Metab. 2007 Jan; 27(1):142-53. PMID: 16736052.
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  258. Rosell A, Ortega-Aznar A, Alvarez-Sabín J, Fernández-Cadenas I, Ribó M, Molina CA, Lo EH, Montaner J. Increased brain expression of matrix metalloproteinase-9 after ischemic and hemorrhagic human stroke. Stroke. 2006 Jun; 37(6):1399-406. PMID: 16690896.
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  259. Wu O, Sumii T, Asahi M, Sasamata M, Ostergaard L, Rosen BR, Lo EH, Dijkhuizen RM. Infarct prediction and treatment assessment with MRI-based algorithms in experimental stroke models. J Cereb Blood Flow Metab. 2007 Jan; 27(1):196-204. PMID: 16685257.
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  260. Lee SR, Kim HY, Rogowska J, Zhao BQ, Bhide P, Parent JM, Lo EH. Involvement of matrix metalloproteinase in neuroblast cell migration from the subventricular zone after stroke. J Neurosci. 2006 Mar 29; 26(13):3491-5. PMID: 16571756.
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  261. Zhao BQ, Wang S, Kim HY, Storrie H, Rosen BR, Mooney DJ, Wang X, Lo EH. Role of matrix metalloproteinases in delayed cortical responses after stroke. Nat Med. 2006 Apr; 12(4):441-5. PMID: 16565723.
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  262. Flaumenhaft R, Lo EH. Different strokes for rodent folks. Nat Methods. 2006 Feb; 3(2):79-80. PMID: 16432514.
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  263. Lee ST, Chu K, Jung KH, Ko SY, Kim EH, Sinn DI, Lee YS, Lo EH, Kim M, Roh JK. Granulocyte colony-stimulating factor enhances angiogenesis after focal cerebral ischemia. Brain Res. 2005 Oct 05; 1058(1-2):120-8. PMID: 16150422.
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  264. Singhal AB, Lo EH, Dalkara T, Moskowitz MA. Advances in stroke neuroprotection: hyperoxia and beyond. Neuroimaging Clin N Am. 2005 Aug; 15(3):697-720, xii-xiii. PMID: 16360598.
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  265. Tsuji K, Aoki T, Tejima E, Arai K, Lee SR, Atochin DN, Huang PL, Wang X, Montaner J, Lo EH. Tissue plasminogen activator promotes matrix metalloproteinase-9 upregulation after focal cerebral ischemia. Stroke. 2005 Sep; 36(9):1954-9. PMID: 16051896.
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  266. Pham W, Zhao BQ, Lo EH, Medarova Z, Rosen B, Moore A. Crossing the blood-brain barrier: a potential application of myristoylated polyarginine for in vivo neuroimaging. Neuroimage. 2005 Oct 15; 28(1):287-92. PMID: 16040255.
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  267. Kim YR, Huang IJ, Lee SR, Tejima E, Mandeville JB, van Meer MP, Dai G, Choi YW, Dijkhuizen RM, Lo EH, Rosen BR. Measurements of BOLD/CBV ratio show altered fMRI hemodynamics during stroke recovery in rats. J Cereb Blood Flow Metab. 2005 Jul; 25(7):820-9. PMID: 15758949.
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  268. Asahi M, Huang Z, Thomas S, Yoshimura S, Sumii T, Mori T, Qiu J, Amin-Hanjani S, Huang PL, Liao JK, Lo EH, Moskowitz MA. Protective effects of statins involving both eNOS and tPA in focal cerebral ischemia. J Cereb Blood Flow Metab. 2005 Jun; 25(6):722-9. PMID: 15716855; PMCID: PMC2742229.
  269. Kim HY, Singhal AB, Lo EH. Normobaric hyperoxia extends the reperfusion window in focal cerebral ischemia. Ann Neurol. 2005 Apr; 57(4):571-5. PMID: 15786465.
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  270. Singhal AB, Benner T, Roccatagliata L, Koroshetz WJ, Schaefer PW, Lo EH, Buonanno FS, Gonzalez RG, Sorensen AG. A pilot study of normobaric oxygen therapy in acute ischemic stroke. Stroke. 2005 Apr; 36(4):797-802. PMID: 15761201.
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  271. van Leyen K, Siddiq A, Ratan RR, Lo EH. Proteasome inhibition protects HT22 neuronal cells from oxidative glutamate toxicity. J Neurochem. 2005 Feb; 92(4):824-30. PMID: 15686484; PMCID: PMC2570092.
  272. Lo EH, Moskowitz MA, Jacobs TP. Exciting, radical, suicidal: how brain cells die after stroke. Stroke. 2005 Feb; 36(2):189-92. PMID: 15637315.
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  273. Lee SR, Wang X, Tsuji K, Lo EH. Extracellular proteolytic pathophysiology in the neurovascular unit after stroke. Neurol Res. 2004 Dec; 26(8):854-61. PMID: 15727269.
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  274. Lo EH. Combination stroke therapy: easy as APC? Nat Med. 2004 Dec; 10(12):1295-6. PMID: 15580249.
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  275. Wang X, Tsuji K, Lee SR, Ning M, Furie KL, Buchan AM, Lo EH. Mechanisms of hemorrhagic transformation after tissue plasminogen activator reperfusion therapy for ischemic stroke. Stroke. 2004 Nov; 35(11 Suppl 1):2726-30. PMID: 15459442.
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  276. Kaur J, Zhao Z, Klein GM, Lo EH, Buchan AM. The neurotoxicity of tissue plasminogen activator? J Cereb Blood Flow Metab. 2004 Sep; 24(9):945-63. PMID: 15356416.
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  277. Lee SR, Lo EH. Induction of caspase-mediated cell death by matrix metalloproteinases in cerebral endothelial cells after hypoxia-reoxygenation. J Cereb Blood Flow Metab. 2004 Jul; 24(7):720-7. PMID: 15241180.
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  278. Gursoy-Ozdemir Y, Qiu J, Matsuoka N, Bolay H, Bermpohl D, Jin H, Wang X, Rosenberg GA, Lo EH, Moskowitz MA. Cortical spreading depression activates and upregulates MMP-9. J Clin Invest. 2004 May; 113(10):1447-55. PMID: 15146242; PMCID: PMC406541.
  279. Arai K, Lee SR, van Leyen K, Kurose H, Lo EH. Involvement of ERK MAP kinase in endoplasmic reticulum stress in SH-SY5Y human neuroblastoma cells. J Neurochem. 2004 Apr; 89(1):232-9. PMID: 15030407.
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  280. Tian X, Gotoh T, Tsuji K, Lo EH, Huang S, Feig LA. Developmentally regulated role for Ras-GRFs in coupling NMDA glutamate receptors to Ras, Erk and CREB. EMBO J. 2004 Apr 07; 23(7):1567-75. PMID: 15029245; PMCID: PMC391062.
  281. Lo EH, Broderick JP, Moskowitz MA. tPA and proteolysis in the neurovascular unit. Stroke. 2004 Feb; 35(2):354-6. PMID: 14757877.
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  282. Lee SR, Tsuji K, Lee SR, Lo EH. Role of matrix metalloproteinases in delayed neuronal damage after transient global cerebral ischemia. J Neurosci. 2004 Jan 21; 24(3):671-8. PMID: 14736853.
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  283. Wang X, Lo EH. Triggers and mediators of hemorrhagic transformation in cerebral ischemia. Mol Neurobiol. 2003 Dec; 28(3):229-44. PMID: 14709787.
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  284. Lee SR, Lo EH. Interactions between p38 mitogen-activated protein kinase and caspase-3 in cerebral endothelial cell death after hypoxia-reoxygenation. Stroke. 2003 Nov; 34(11):2704-9. PMID: 14551401.
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  285. Wang X, Lee SR, Arai K, Lee SR, Tsuji K, Rebeck GW, Lo EH. Lipoprotein receptor-mediated induction of matrix metalloproteinase by tissue plasminogen activator. Nat Med. 2003 Oct; 9(10):1313-7. PMID: 12960961.
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  286. Arai K, Lee SR, Lo EH. Essential role for ERK mitogen-activated protein kinase in matrix metalloproteinase-9 regulation in rat cortical astrocytes. Glia. 2003 Sep; 43(3):254-64. PMID: 12898704.
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  287. Asahi M, Rammohan R, Sumii T, Wang X, Pauw RJ, Weissig V, Torchilin VP, Lo EH. Antiactin-targeted immunoliposomes ameliorate tissue plasminogen activator-induced hemorrhage after focal embolic stroke. J Cereb Blood Flow Metab. 2003 Aug; 23(8):895-9. PMID: 12902833.
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  288. Lo EH, Dalkara T, Moskowitz MA. Mechanisms, challenges and opportunities in stroke. Nat Rev Neurosci. 2003 May; 4(5):399-415. PMID: 12728267.
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  289. Moskowitz MA, Lo EH. Neurogenesis and apoptotic cell death. Stroke. 2003 Feb; 34(2):324-6. PMID: 12574524.
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  290. Dijkhuizen RM, Singhal AB, Mandeville JB, Wu O, Halpern EF, Finklestein SP, Rosen BR, Lo EH. Correlation between brain reorganization, ischemic damage, and neurologic status after transient focal cerebral ischemia in rats: a functional magnetic resonance imaging study. J Neurosci. 2003 Jan 15; 23(2):510-7. PMID: 12533611.
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  291. Petty MA, Lo EH. Junctional complexes of the blood-brain barrier: permeability changes in neuroinflammation. Prog Neurobiol. 2002 Dec; 68(5):311-23. PMID: 12531232.
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  292. Aoki T, Sumii T, Mori T, Wang X, Lo EH. Blood-brain barrier disruption and matrix metalloproteinase-9 expression during reperfusion injury: mechanical versus embolic focal ischemia in spontaneously hypertensive rats. Stroke. 2002 Nov; 33(11):2711-7. PMID: 12411666.
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  293. Mori T, Wang X, Aoki T, Lo EH. Downregulation of matrix metalloproteinase-9 and attenuation of edema via inhibition of ERK mitogen activated protein kinase in traumatic brain injury. J Neurotrauma. 2002 Nov; 19(11):1411-9. PMID: 12490006.
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  294. Ge Y, Wang X, Chen Z, Landman N, Lo EH, Kang JX. Gene transfer of the Caenorhabditis elegans n-3 fatty acid desaturase inhibits neuronal apoptosis. J Neurochem. 2002 Sep; 82(6):1360-6. PMID: 12354283.
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  295. Dijkhuizen RM, Asahi M, Wu O, Rosen BR, Lo EH. Rapid breakdown of microvascular barriers and subsequent hemorrhagic transformation after delayed recombinant tissue plasminogen activator treatment in a rat embolic stroke model. Stroke. 2002 Aug; 33(8):2100-4. PMID: 12154270.
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  296. Singhal AB, Wang X, Sumii T, Mori T, Lo EH. Effects of normobaric hyperoxia in a rat model of focal cerebral ischemia-reperfusion. J Cereb Blood Flow Metab. 2002 Jul; 22(7):861-8. PMID: 12142571.
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  297. Lo EH, Wang X, Cuzner ML. Extracellular proteolysis in brain injury and inflammation: role for plasminogen activators and matrix metalloproteinases. J Neurosci Res. 2002 Jul 01; 69(1):1-9. PMID: 12111810.
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  298. Wang X, Mori T, Sumii T, Lo EH. Hemoglobin-induced cytotoxicity in rat cerebral cortical neurons: caspase activation and oxidative stress. Stroke. 2002 Jul; 33(7):1882-8. PMID: 12105370.
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  299. Wang X, Mori T, Jung JC, Fini ME, Lo EH. Secretion of matrix metalloproteinase-2 and -9 after mechanical trauma injury in rat cortical cultures and involvement of MAP kinase. J Neurotrauma. 2002 May; 19(5):615-25. PMID: 12042096.
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  300. Mori T, Wang X, Jung JC, Sumii T, Singhal AB, Fini ME, Dixon CE, Alessandrini A, Lo EH. Mitogen-activated protein kinase inhibition in traumatic brain injury: in vitro and in vivo effects. J Cereb Blood Flow Metab. 2002 Apr; 22(4):444-52. PMID: 11919515.
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  301. Singhal AB, Dijkhuizen RM, Rosen BR, Lo EH. Normobaric hyperoxia reduces MRI diffusion abnormalities and infarct size in experimental stroke. Neurology. 2002 Mar 26; 58(6):945-52. PMID: 11914413.
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  302. Sumii T, Lo EH. Involvement of matrix metalloproteinase in thrombolysis-associated hemorrhagic transformation after embolic focal ischemia in rats. Stroke. 2002 Mar; 33(3):831-6. PMID: 11872911.
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  303. Mori T, Wang X, Kline AE, Siao CJ, Dixon CE, Tsirka SE, Lo EH. Reduced cortical injury and edema in tissue plasminogen activator knockout mice after brain trauma. Neuroreport. 2001 Dec 21; 12(18):4117-20. PMID: 11742249.
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  304. Chu AC, Tsang SY, Lo EH, Fung KP. Low density lipoprotein as a targeted carrier for doxorubicin in nude mice bearing human hepatoma HepG2 cells. Life Sci. 2001 Dec 21; 70(5):591-601. PMID: 11811903.
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  305. Lo EH, Singhal AB, Torchilin VP, Abbott NJ. Drug delivery to damaged brain. Brain Res Brain Res Rev. 2001 Dec; 38(1-2):140-8. PMID: 11750930.
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  306. Wang X, Shimizu-Sasamata M, Moskowitz MA, Newcomb R, Lo EH. Profiles of glutamate and GABA efflux in core versus peripheral zones of focal cerebral ischemia in mice. Neurosci Lett. 2001 Nov 09; 313(3):121-4. PMID: 11682142.
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  307. Asahi M, Wang X, Mori T, Sumii T, Jung JC, Moskowitz MA, Fini ME, Lo EH. Effects of matrix metalloproteinase-9 gene knock-out on the proteolysis of blood-brain barrier and white matter components after cerebral ischemia. J Neurosci. 2001 Oct 01; 21(19):7724-32. PMID: 11567062.
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  308. Asahi M, Sumii T, Fini ME, Itohara S, Lo EH. Matrix metalloproteinase 2 gene knockout has no effect on acute brain injury after focal ischemia. Neuroreport. 2001 Sep 17; 12(13):3003-7. PMID: 11588620.
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  309. Dijkhuizen RM, Asahi M, Wu O, Rosen BR, Lo EH. Delayed rt-PA treatment in a rat embolic stroke model: diagnosis and prognosis of ischemic injury and hemorrhagic transformation with magnetic resonance imaging. J Cereb Blood Flow Metab. 2001 Aug; 21(8):964-71. PMID: 11487732.
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  310. Tejima E, Katayama Y, Suzuki Y, Kano T, Lo EH. Hemorrhagic transformation after fibrinolysis with tissue plasminogen activator: evaluation of role of hypertension with rat thromboembolic stroke model. Stroke. 2001 Jun; 32(6):1336-40. PMID: 11387496.
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  311. Sumii T, Singhal AB, Asahi M, Shimizu-Sasamata M, Suzuki M, Miyata K, Lo EH. Protective effects of pamiteplase, a modified t-PA, in a rat model of embolic stroke. Neuroreport. 2001 Mar 05; 12(3):615-8. PMID: 11234775.
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  312. Asahi M, Asahi K, Jung JC, del Zoppo GJ, Fini ME, Lo EH. Role for matrix metalloproteinase 9 after focal cerebral ischemia: effects of gene knockout and enzyme inhibition with BB-94. J Cereb Blood Flow Metab. 2000 Dec; 20(12):1681-9. PMID: 11129784.
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  313. Wang X, Jung J, Asahi M, Chwang W, Russo L, Moskowitz MA, Dixon CE, Fini ME, Lo EH. Effects of matrix metalloproteinase-9 gene knock-out on morphological and motor outcomes after traumatic brain injury. J Neurosci. 2000 Sep 15; 20(18):7037-42. PMID: 10995849.
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  314. Aymard C, Katz R, Lafitte C, Lo E, Pénicaud A, Pradat-Diehl P, Raoul S. Presynaptic inhibition and homosynaptic depression: a comparison between lower and upper limbs in normal human subjects and patients with hemiplegia. Brain. 2000 Aug; 123 ( Pt 8):1688-702. PMID: 10908198.
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  315. Sasamata M, Moskowitz MA, Lo EH. [New method for evaluating the effects of neuroprotective therapy in the hemodynamic penumbra]. Nihon Yakurigaku Zasshi. 2000 Mar; 115(3):161-9. PMID: 10876801.
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  316. Asahi M, Asahi K, Wang X, Lo EH. Reduction of tissue plasminogen activator-induced hemorrhage and brain injury by free radical spin trapping after embolic focal cerebral ischemia in rats. J Cereb Blood Flow Metab. 2000 Mar; 20(3):452-7. PMID: 10724108.
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  317. Matsushita K, Meng W, Wang X, Asahi M, Asahi K, Moskowitz MA, Lo EH. Evidence for apoptosis after intercerebral hemorrhage in rat striatum. J Cereb Blood Flow Metab. 2000 Feb; 20(2):396-404. PMID: 10698078.
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  318. Kano T, Katayama Y, Tejima E, Lo EH. Hemorrhagic transformation after fibrinolytic therapy with tissue plasminogen activator in a rat thromboembolic model of stroke. Brain Res. 2000 Jan 31; 854(1-2):245-8. PMID: 10784130.
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  319. Ayata C, Shimizu-Sasamata M, Lo EH, Noebels JL, Moskowitz MA. Impaired neurotransmitter release and elevated threshold for cortical spreading depression in mice with mutations in the alpha1A subunit of P/Q type calcium channels. Neuroscience. 2000; 95(3):639-45. PMID: 10670432.
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  320. Meng W, Wang X, Asahi M, Kano T, Asahi K, Ackerman RH, Lo EH. Effects of tissue type plasminogen activator in embolic versus mechanical models of focal cerebral ischemia in rats. J Cereb Blood Flow Metab. 1999 Dec; 19(12):1316-21. PMID: 10598935.
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  321. Wang X, Asahi M, Lo EH. Tissue type plasminogen activator amplifies hemoglobin-induced neurotoxicity in rat neuronal cultures. Neurosci Lett. 1999 Oct 22; 274(2):79-82. PMID: 10553942.
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  322. Li D, Desai-Yajnik V, Lo E, Schapira M, Abagyan R, Samuels HH. NRIF3 is a novel coactivator mediating functional specificity of nuclear hormone receptors. Mol Cell Biol. 1999 Oct; 19(10):7191-202. PMID: 10490654; PMCID: PMC84712.
  323. Strausbaugh HJ, Green PG, Lo E, Tangemann K, Reichling DB, Rosen SD, Levine JD. Painful stimulation suppresses joint inflammation by inducing shedding of L-selectin from neutrophils. Nat Med. 1999 Sep; 5(9):1057-61. PMID: 10470085.
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  324. Abbott NJ, Chugani DC, Zaharchuk G, Rosen BR, Lo EH. Delivery of imaging agents into brain. Adv Drug Deliv Rev. 1999 Apr 05; 37(1-3):253-77. PMID: 10837739.
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  325. Wan H, Hu D, Lo E, Holmgren CJ, He D, Liu Y. [Atraumatic restorative treatment fillings and fissure sealants in permanent teeth--a 2-year study]. Hua Xi Kou Qiang Yi Xue Za Zhi. 1999 Feb; 17(1):42-5. PMID: 12539320.
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  326. Newcomb R, Pierce AR, Kano T, Meng W, Bosque-Hamilton P, Taylor L, Curthoys N, Lo EH. Characterization of mitochondrial glutaminase and amino acids at prolonged times after experimental focal cerebral ischemia. Brain Res. 1998 Nov 30; 813(1):103-11. PMID: 9824679.
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  327. Shimizu-Sasamata M, Bosque-Hamilton P, Huang PL, Moskowitz MA, Lo EH. Attenuated neurotransmitter release and spreading depression-like depolarizations after focal ischemia in mutant mice with disrupted type I nitric oxide synthase gene. J Neurosci. 1998 Nov 15; 18(22):9564-71. PMID: 9801393.
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  328. Kano T, Shimizu-Sasamata M, Huang PL, Moskowitz MA, Lo EH. Effects of nitric oxide synthase gene knockout on neurotransmitter release in vivo. Neuroscience. 1998 Oct; 86(3):695-9. PMID: 9692709.
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  329. Shimizu-Sasamata M, Kano T, Rogowska J, Wolf GL, Moskowitz MA, Lo EH. YM872, a highly water-soluble AMPA receptor antagonist, preserves the hemodynamic penumbra and reduces brain injury after permanent focal ischemia in rats. Stroke. 1998 Oct; 29(10):2141-8. PMID: 9756596.
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  330. Lo EH, Bosque-Hamilton P, Meng W. Inhibition of poly(ADP-ribose) polymerase: reduction of ischemic injury and attenuation of N-methyl-D-aspartate-induced neurotransmitter dysregulation. Stroke. 1998 Apr; 29(4):830-6. PMID: 9550519.
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  331. Lo EH, Pierce AR, Matsumoto K, Kano T, Evans CJ, Newcomb R. Alterations in K+ evoked profiles of neurotransmitter and neuromodulator amino acids after focal ischemia-reperfusion. Neuroscience. 1998 Mar; 83(2):449-58. PMID: 9460753.
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  332. Huang PL, Lo EH. Genetic analysis of NOS isoforms using nNOS and eNOS knockout animals. Prog Brain Res. 1998; 118:13-25. PMID: 9932431.
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  333. Pierce AR, Lo EH, Mandeville JB, Gonzalez RG, Rosen BR, Wolf GL. MRI measurements of water diffusion and cerebral perfusion: their relationship in a rat model of focal cerebral ischemia. J Cereb Blood Flow Metab. 1997 Feb; 17(2):183-90. PMID: 9040498.
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  334. Lo EH, Pierce AR, Mandeville JB, Rosen BR. Neuroprotection with NBQX in rat focal cerebral ischemia. Effects on ADC probability distribution functions and diffusion-perfusion relationships. Stroke. 1997 Feb; 28(2):439-46; discussion 446-7. PMID: 9040703.
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  335. Hamberg LM, Hunter GJ, Kierstead D, Lo EH, Gilberto González R, Wolf GL. Measurement of cerebral blood volume with subtraction three-dimensional functional CT. AJNR Am J Neuroradiol. 1996 Nov-Dec; 17(10):1861-9. PMID: 8933870.
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  336. Lo EH, Hara H, Rogowska J, Trocha M, Pierce AR, Huang PL, Fishman MC, Wolf GL, Moskowitz MA. Temporal correlation mapping analysis of the hemodynamic penumbra in mutant mice deficient in endothelial nitric oxide synthase gene expression. Stroke. 1996 Aug; 27(8):1381-5. PMID: 8711806.
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  337. Yelnik A, Bonan I, Debray M, Lo E, Gelbert F, Bussel B. Changes in the execution of a complex manual task after ipsilateral ischemic cerebral hemispheric stroke. Arch Phys Med Rehabil. 1996 Aug; 77(8):806-10. PMID: 8702376.
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  338. Lo EH, Rogowska J, Batchelder KF, Wolf GL. Hemodynamic alterations in focal cerebral ischemia: temporal correlation analysis for functional imaging. Neurol Res. 1996 Apr; 18(2):150-6. PMID: 9162870.
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  339. Matsumoto K, Lo EH, Pierce AR, Halpern EF, Newcomb R. Secondary elevation of extracellular neurotransmitter amino acids in the reperfusion phase following focal cerebral ischemia. J Cereb Blood Flow Metab. 1996 Jan; 16(1):114-24. PMID: 8530544.
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  340. Lo EH, Rogowska J, Bogorodzki P, Trocha M, Matsumoto K, Saffran B, Wolf GL. Temporal correlation analysis of penumbral dynamics in focal cerebral ischemia. J Cereb Blood Flow Metab. 1996 Jan; 16(1):60-8. PMID: 8530556.
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  341. Pan Y, Lo EH, Matsumoto K, Hamberg L, Jiang H. Quantitative and dynamic MRI of neuroprotection in experimental stroke. J Neurol Sci. 1995 Aug; 131(2):128-34. PMID: 7595637.
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  342. Matsumoto K, Lo EH, Pierce AR, Wei H, Garrido L, Kowall NW. Role of vasogenic edema and tissue cavitation in ischemic evolution on diffusion-weighted imaging: comparison with multiparameter MR and immunohistochemistry. AJNR Am J Neuroradiol. 1995 May; 16(5):1107-15. PMID: 7639135.
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  343. Lo EH, Matsumoto K, Pierce AR, Garrido L, Luttinger D. Pharmacologic reversal of acute changes in diffusion-weighted magnetic resonance imaging in focal cerebral ischemia. J Cereb Blood Flow Metab. 1994 Jul; 14(4):597-603. PMID: 8014206.
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  344. Safran C, Gladstone S, Lo E, Boro JE, Slack WV. Trends in computer applications in medical care. MD Comput. 1994 May-Jun; 11(3):155-9. PMID: 8057789.
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  345. Lo EH, Pan Y, Matsumoto K, Kowall NW. Blood-brain barrier disruption in experimental focal ischemia: comparison between in vivo MRI and immunocytochemistry. Magn Reson Imaging. 1994; 12(3):403-11. PMID: 8007769.
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  346. Lo EH. A theoretical analysis of hemodynamic and biomechanical alterations in intracranial AVMs after radiosurgery. Int J Radiat Oncol Biol Phys. 1993 Sep 30; 27(2):353-61. PMID: 8407410.
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  347. Lo EH, Steinberg GK, Panahian N, Maidment NT, Newcomb R. Profiles of extracellular amino acid changes in focal cerebral ischaemia: effects of mild hypothermia. Neurol Res. 1993 Aug; 15(4):281-7. PMID: 8105409.
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  348. Lo EH. A haemodynamic analysis of intracranial arteriovenous malformations. Neurol Res. 1993 Feb; 15(1):51-5. PMID: 8098854.
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  349. Lo EH, Steinberg GK. Effects of hypothermia on evoked potentials, magnetic resonance imaging, and blood flow in focal ischemia in rabbits. Stroke. 1992 Jun; 23(6):889-93. PMID: 1595110.
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  350. Lo EH, Frankel KA, Steinberg GK, DeLaPaz RL, Fabrikant JI. High-dose single-fraction brain irradiation: MRI, cerebral blood flow, electrophysiological, and histological studies. Int J Radiat Oncol Biol Phys. 1992; 22(1):47-55. PMID: 1727129.
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  351. Steinberg GK, Lo EH, Kunis DM, Grant GA, Poljak A, DeLaPaz R. Dextromethorphan alters cerebral blood flow and protects against cerebral injury following focal ischemia. Neurosci Lett. 1991 Dec 09; 133(2):225-8. PMID: 1816501.
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  352. Lo EH, Sun GH, Steinberg GK. Effects of NMDA and calcium channel antagonists on regional cerebral blood flow. Neurosci Lett. 1991 Sep 30; 131(1):17-20. PMID: 1791974.
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  353. Lo EH, Steinberg GK. Effects of dextromethorphan on regional cerebral blood flow in focal cerebral ischemia. J Cereb Blood Flow Metab. 1991 Sep; 11(5):803-9. PMID: 1874811.
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  354. Lo EH, DeLaPaz RL, Frankel KA, Poljak A, Phillips MH, Brennan KM, Woodruf KH, Valk PE, Steinberg GK, Fabrikant JI. MRI and PET of delayed heavy-ion radiation injury in the rabbit brain. Int J Radiat Oncol Biol Phys. 1991 Apr; 20(4):689-96. PMID: 2004945.
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  355. Lo EH, Fabrikant JI. Delayed biologic reactions to stereotactic charged-particle radiosurgery in the human brain. Stereotact Funct Neurosurg. 1991; 56(4):197-212. PMID: 1808645.
    View in: PubMed
  356. Lo EH, Frankel KA, Delapaz RL, Poljak A, Woodruff KH, Brennan KM, Phillips MH, Valk PE, Steinberg GK, Fabrikant JI. Cerebrovascular and metabolic perturbations in delayed heavy charged particle radiation injury. Brain Res. 1989 Dec 11; 504(1):168-72. PMID: 2598014.
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  357. Fang R, Lo E, Lim TW. The 1982 dengue epidemic in Malaysia: epidemiological, serological and virological aspects. Southeast Asian J Trop Med Public Health. 1984 Mar; 15(1):51-8. PMID: 6740379.
    View in: PubMed
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