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Kiyoshi Itagaki, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Kim HI, Park J, Konecna B, Huang W, Riça I, Gallo D, Otterbein LE, Itagaki K, Hauser CJ. Plasma and wound fluids from trauma patients suppress neutrophil extracellular respiratory burst. J Trauma Acute Care Surg. 2022 02 01; 92(2):330-338. PMID: 34789698; PMCID: PMC8792304.
    Citations:    Fields:    Translation:HumansAnimalsCells
  2. Zhang Q, Kwon WY, Vlková B, Riça I, Kaczmarek E, Park J, Kim HI, Konecna B, Jung F, Douglas G, Otterbein LE, Hauser CJ, Itagaki K. Direct Airway Instillation of Neutrophils Overcomes Chemotactic Deficits Induced by Injury. Shock. 2021 07 01; 56(1):119-124. PMID: 33181622; PMCID: PMC8513109.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  3. Itagaki K, Riça I, Konecna B, Kim HI, Park J, Kaczmarek E, Hauser CJ. Role of Mitochondria-Derived Danger Signals Released After Injury in Systemic Inflammation and Sepsis. Antioxid Redox Signal. 2021 11 20; 35(15):1273-1290. PMID: 33847158; PMCID: PMC8905257.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  4. Kwon WY, Suh GJ, Jung YS, Park SM, Oh S, Kim SH, Lee AR, Kim JY, Kim H, Kim KA, Kim Y, Kim BC, Kim T, Kim KS, Itagaki K, Hauser CJ. Circulating mitochondrial N-formyl peptides contribute to secondary nosocomial infection in patients with septic shock. Proc Natl Acad Sci U S A. 2021 04 27; 118(17). PMID: 33888581.
    Citations: 1     Fields:    Translation:HumansCells
  5. Konecna B, Park J, Kwon WY, Vlkova B, Zhang Q, Huang W, Kim HI, Yaffe MB, Otterbein LE, Itagaki K, Hauser CJ. Monocyte exocytosis of mitochondrial danger-associated molecular patterns in sepsis suppresses neutrophil chemotaxis. J Trauma Acute Care Surg. 2021 01 01; 90(1):46-53. PMID: 33021603.
    Citations: 9     Fields:    Translation:HumansCells
  6. Cahill LA, Joughin BA, Kwon WY, Itagaki K, Kirk CH, Shapiro NI, Otterbein LE, Yaffe MB, Lederer JA, Hauser CJ. Multiplexed Plasma Immune Mediator Signatures Can Differentiate Sepsis From NonInfective SIRS: American Surgical Association 2020 Annual Meeting Paper. Ann Surg. 2020 10; 272(4):604-610. PMID: 32932316.
    Citations: 3     Fields:    Translation:Humans
  7. Itagaki K, Kaczmarek E, Kwon WY, Chen L, Vlková B, Zhang Q, Riça I, Yaffe MB, Campbell Y, Marusich MF, Wang JM, Gong WH, Gao JL, Jung F, Douglas G, Otterbein LE, Hauser CJ. Formyl Peptide Receptor-1 Blockade Prevents Receptor Regulation by Mitochondrial Danger-Associated Molecular Patterns and Preserves Neutrophil Function After Trauma. Crit Care Med. 2020 02; 48(2):e123-e132. PMID: 31939811; PMCID: PMC7337247.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  8. Itagaki K, Kaczmarek E, Kwon WY, Chen L, Vlková B, Zhang Q, Riça I, Yaffe MB, Campbell Y, Marusich MF, Wang JM, Gong WH, Gao JL, Jung F, Douglas G, Otterbein LE, Hauser CJ. Formyl Peptide Receptor-1 Blockade Prevents Receptor Regulation by Mitochondrial Danger-Associated Molecular Patterns and Preserves Neutrophil Function After Trauma. Crit Care Med. 2019 Nov 15. PMID: 31743227.
  9. Singel KL, Grzankowski KS, Khan ANMNH, Grimm MJ, D'Auria AC, Morrell K, Eng KH, Hylander B, Mayor PC, Emmons TR, Lénárt N, Fekete R, Környei Z, Muthukrishnan U, Gilthorpe JD, Urban CF, Itagaki K, Hauser CJ, Leifer C, Moysich KB, Odunsi K, Dénes Á, Segal BH. Mitochondrial DNA in the tumour microenvironment activates neutrophils and is associated with worse outcomes in patients with advanced epithelial ovarian cancer. Br J Cancer. 2019 01; 120(2):207-217. PMID: 30518816; PMCID: PMC6342981.
    Citations: 31     Fields:    Translation:HumansCells
  10. Kaczmarek E, Hauser CJ, Kwon WY, Riça I, Chen L, Sandler N, Otterbein LE, Campbell Y, Cook CH, Yaffe MB, Marusich MF, Itagaki K. A subset of five human mitochondrial formyl peptides mimics bacterial peptides and functionally deactivates human neutrophils. J Trauma Acute Care Surg. 2018 11; 85(5):936-943. PMID: 29787548.
    Citations: 14     Fields:    Translation:HumansCells
  11. Aswani A, Manson J, Itagaki K, Chiazza F, Collino M, Wupeng WL, Chan TK, Wong WSF, Hauser CJ, Thiemermann C, Brohi K. Scavenging Circulating Mitochondrial DNA as a Potential Therapeutic Option for Multiple Organ Dysfunction in Trauma Hemorrhage. Front Immunol. 2018; 9:891. PMID: 29867926.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  12. Itagaki K, Riça I, Zhang J, Gallo D, DePrato M, Otterbein LE, Hauser CJ. Intratracheal instillation of neutrophils rescues bacterial overgrowth initiated by trauma damage-associated molecular patterns. J Trauma Acute Care Surg. 2017 05; 82(5):853-860. PMID: 28431414; PMCID: PMC5405734.
    Citations: 5     Fields:    Translation:AnimalsCells
  13. Sandler N, Kaczmarek E, Itagaki K, Zheng Y, Otterbein L, Khabbaz K, Liu D, Senthilnathan V, Gruen RL, Hauser CJ. Mitochondrial DAMPs Are Released During Cardiopulmonary Bypass Surgery and Are Associated With Postoperative Atrial Fibrillation. Heart Lung Circ. 2018 Jan; 27(1):122-129. PMID: 28487062.
    Citations: 29     Fields:    Translation:HumansCells
  14. Yi J, Slaughter A, Kotter CV, Moore EE, Hauser CJ, Itagaki K, Wohlauer M, Frank DN, Silliman C, Banerjee A, Peltz E. A "CLEAN CASE" OF SYSTEMIC INJURY: MESENTERIC LYMPH AFTER HEMORRHAGIC SHOCK ELICITS A STERILE INFLAMMATORY RESPONSE. Shock. 2015 Oct; 44(4):336-40. PMID: 26196840.
    Citations: 11     Fields:    Translation:Animals
  15. Mayer CL, Parello CS, Lee BC, Itagaki K, Kurosawa S, Stearns-Kurosawa DJ. Pro-Coagulant Endothelial Dysfunction Results from EHEC Shiga Toxins and Host Damage-Associated Molecular Patterns. Front Immunol. 2015; 6:155. PMID: 25904918.
    Citations: 4     Fields:    
  16. Itagaki K, Kaczmarek E, Lee YT, Tang IT, Isal B, Adibnia Y, Sandler N, Grimm MJ, Segal BH, Otterbein LE, Hauser CJ. Mitochondrial DNA released by trauma induces neutrophil extracellular traps. PLoS One. 2015; 10(3):e0120549. PMID: 25774524.
    Citations: 75     Fields:    Translation:HumansCells
  17. Li H, Itagaki K, Sandler N, Gallo D, Galenkamp A, Kaczmarek E, Livingston DH, Zeng Y, Lee YT, Tang IT, Isal B, Otterbein L, Hauser CJ. Mitochondrial damage-associated molecular patterns from fractures suppress pulmonary immune responses via formyl peptide receptors 1 and 2. J Trauma Acute Care Surg. 2015 Feb; 78(2):272-9; discussion 279-81. PMID: 25757111; PMCID: PMC4357317.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  18. Zhao C, Itagaki K, Gupta A, Odom S, Sandler N, Hauser CJ. Mitochondrial damage-associated molecular patterns released by abdominal trauma suppress pulmonary immune responses. J Trauma Acute Care Surg. 2014 May; 76(5):1222-7. PMID: 24747452; PMCID: PMC4523560.
    Citations: 14     Fields:    Translation:AnimalsCells
  19. Ma H, Chu M, Itagaki K, Xin P, Zhou X, Zhang D, Wang Y, Fu J, Sun S. Formulation and in vitro characterization of a novel solid lipid-based drug delivery system. Chem Pharm Bull (Tokyo). 2014; 62(12):1173-9. PMID: 25450625.
    Citations: 1     Fields:    
  20. Chu MJ, Wang YZ, Itagaki K, Ma HX, Xin P, Zhou XG, Chen GY, Li S, Sun SQ. Identification of active compounds from Caesalpinia sappan L. extracts suppressing IL-6 production in RAW 264.7 cells by PLS. J Ethnopharmacol. 2013 Jun 21; 148(1):37-44. PMID: 23567033.
    Citations: 4     Fields:    Translation:AnimalsCells
  21. Sun S, Sursal T, Adibnia Y, Zhao C, Zheng Y, Li H, Otterbein LE, Hauser CJ, Itagaki K. Mitochondrial DAMPs increase endothelial permeability through neutrophil dependent and independent pathways. PLoS One. 2013; 8(3):e59989. PMID: 23527291.
    Citations: 87     Fields:    Translation:HumansCells
  22. Davidson BA, Vethanayagam RR, Grimm MJ, Mullan BA, Raghavendran K, Blackwell TS, Freeman ML, Ayyasamy V, Singh KK, Sporn MB, Itagaki K, Hauser CJ, Knight PR, Segal BH. NADPH oxidase and Nrf2 regulate gastric aspiration-induced inflammation and acute lung injury. J Immunol. 2013 Feb 15; 190(4):1714-24. PMID: 23296708; PMCID: PMC3563868.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  23. Sursal T, Stearns-Kurosawa DJ, Itagaki K, Oh SY, Sun S, Kurosawa S, Hauser CJ. Plasma bacterial and mitochondrial DNA distinguish bacterial sepsis from sterile systemic inflammatory response syndrome and quantify inflammatory tissue injury in nonhuman primates. Shock. 2013 Jan; 39(1):55-62. PMID: 23247122.
    Citations: 49     Fields:    Translation:Animals
  24. Yuan L, Le Bras A, Sacharidou A, Itagaki K, Zhan Y, Kondo M, Carman CV, Davis GE, Aird WC, Oettgen P. ETS-related gene (ERG) controls endothelial cell permeability via transcriptional regulation of the claudin 5 (CLDN5) gene. J Biol Chem. 2012 Feb 24; 287(9):6582-91. PMID: 22235125.
    Citations: 47     Fields:    Translation:HumansCells
  25. Itagaki K, Adibnia Y, Sun S, Zhao C, Sursal T, Chen Y, Junger W, Hauser CJ. Bacterial DNA induces pulmonary damage via TLR-9 through cross-talk with neutrophils. Shock. 2011 Dec; 36(6):548-52. PMID: 21937948.
    Citations: 18     Fields:    Translation:HumansCells
  26. Hauser CJ, Sursal T, Rodriguez EK, Appleton PT, Zhang Q, Itagaki K. Mitochondrial damage associated molecular patterns from femoral reamings activate neutrophils through formyl peptide receptors and P44/42 MAP kinase. J Orthop Trauma. 2010 Sep; 24(9):534-8. PMID: 20736789.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  27. Zhang Q, Itagaki K, Hauser CJ. Mitochondrial DNA is released by shock and activates neutrophils via p38 map kinase. Shock. 2010 Jul; 34(1):55-9. PMID: 19997055.
    Citations: 141     Fields:    Translation:HumansAnimalsCells
  28. Raoof M, Zhang Q, Itagaki K, Hauser CJ. Mitochondrial peptides are potent immune activators that activate human neutrophils via FPR-1. J Trauma. 2010 Jun; 68(6):1328-32; discussion 1332-4. PMID: 20539176.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  29. Kawabata KS, Maeda K, Nomoto K, Taubenberger S, Tanaka M, Deng J, Pian E, Hattori T, Itagaki K. A massive star origin for an unusual helium-rich supernova in an elliptical galaxy. Nature. 2010 May 20; 465(7296):326-8. PMID: 20485430.
    Citations: 2     Fields:    
  30. Itagaki K, Zhang Q, Hauser CJ. Sphingosine kinase inhibition alleviates endothelial permeability induced by thrombin and activated neutrophils. Shock. 2010 Apr; 33(4):381-6. PMID: 19851125.
    Citations: 4     Fields:    Translation:HumansCells
  31. Zhang Q, Raoof M, Chen Y, Sumi Y, Sursal T, Junger W, Brohi K, Itagaki K, Hauser CJ. Circulating mitochondrial DAMPs cause inflammatory responses to injury. Nature. 2010 Mar 04; 464(7285):104-7. PMID: 20203610; PMCID: PMC2843437.
    Citations: 1413     Fields:    Translation:HumansAnimalsCells
  32. Itagaki K, Menconi M, Antoniu B, Zhang Q, Gonnella P, Soybel D, Hauser C, Hasselgren PO. Dexamethasone stimulates store-operated calcium entry and protein degradation in cultured L6 myotubes through a phospholipase A(2)-dependent mechanism. Am J Physiol Cell Physiol. 2010 May; 298(5):C1127-39. PMID: 20107037.
    Citations: 12     Fields:    Translation:AnimalsCells
  33. Itagaki K, Barton BE, Murphy TF, Taheri S, Shu P, Huang H, Jordan ML. Eicosanoid-induced store-operated calcium entry in dendritic cells. J Surg Res. 2011 Aug; 169(2):301-10. PMID: 20080257.
    Citations: 8     Fields:    Translation:AnimalsCells
  34. Itagaki K, Yun JK, Hengst JA, Yatani A, Hauser CJ, Spolarics Z, Deitch EA. Sphingosine 1-phosphate has dual functions in the regulation of endothelial cell permeability and Ca2+ metabolism. J Pharmacol Exp Ther. 2007 Oct; 323(1):186-91. PMID: 17626797.
    Citations: 13     Fields:    Translation:HumansCells
  35. Deitch EA, Feketeova E, Adams JM, Forsythe RM, Xu DZ, Itagaki K, Redl H. Lymph from a primate baboon trauma hemorrhagic shock model activates human neutrophils. Shock. 2006 May; 25(5):460-3. PMID: 16680010.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  36. Hauser CJ, Kannan KB, Deitch EA, Itagaki K. Non-specific effects of 4-chloro-m-cresol may cause calcium flux and respiratory burst in human neutrophils. Biochem Biophys Res Commun. 2005 Nov 04; 336(4):1087-95. PMID: 16168959.
    Citations: 1     Fields:    Translation:HumansCells
  37. Tarlowe MH, Duffy A, Kannan KB, Itagaki K, Lavery RF, Livingston DH, Bankey P, Hauser CJ. Prospective study of neutrophil chemokine responses in trauma patients at risk for pneumonia. Am J Respir Crit Care Med. 2005 Apr 01; 171(7):753-9. PMID: 15618463.
    Citations: 23     Fields:    Translation:HumansCells
  38. Itagaki K, Kannan KB, Hauser CJ. Lysophosphatidic acid triggers calcium entry through a non-store-operated pathway in human neutrophils. J Leukoc Biol. 2005 Feb; 77(2):181-9. PMID: 15522918.
    Citations: 11     Fields:    Translation:HumansCells
  39. Itagaki K, Kannan KB, Singh BB, Hauser CJ. Cytoskeletal reorganization internalizes multiple transient receptor potential channels and blocks calcium entry into human neutrophils. J Immunol. 2004 Jan 01; 172(1):601-7. PMID: 14688372.
    Citations: 23     Fields:    Translation:HumansCells
  40. Tarlowe MH, Kannan KB, Itagaki K, Adams JM, Livingston DH, Hauser CJ. Inflammatory chemoreceptor cross-talk suppresses leukotriene B4 receptor 1-mediated neutrophil calcium mobilization and chemotaxis after trauma. J Immunol. 2003 Aug 15; 171(4):2066-73. PMID: 12902512.
    Citations: 13     Fields:    Translation:HumansCells
  41. Itagaki K, Hauser CJ. Sphingosine 1-phosphate, a diffusible calcium influx factor mediating store-operated calcium entry. J Biol Chem. 2003 Jul 25; 278(30):27540-7. PMID: 12746430.
    Citations: 32     Fields:    Translation:HumansCells
  42. Itagaki K, Kannan KB, Livingston DH, Deitch EA, Fekete Z, Hauser CJ. Store-operated calcium entry in human neutrophils reflects multiple contributions from independently regulated pathways. J Immunol. 2002 Apr 15; 168(8):4063-9. PMID: 11937565.
    Citations: 33     Fields:    Translation:HumansCells
  43. Kuniyasu A, Itagaki K, Shibano T, Iino M, Kraft G, Schwartz A, Nakayama H. Photochemical identification of transmembrane segment IVS6 as the binding region of semotiadil, a new modulator for the L-type voltage-dependent Ca2+ channel. J Biol Chem. 1998 Feb 20; 273(8):4635-41. PMID: 9468522.
    Citations: 2     Fields:    Translation:AnimalsCells
  44. Watanabe T, Kalasz H, Yabana H, Kuniyasu A, Mershon J, Itagaki K, Vaghy PL, Naito K, Nakayama H, Schwartz A. Azidobutyryl clentiazem, a new photoactivatable diltiazem analog, labels benzothiazepine binding sites in the alpha 1 subunit of the skeletal muscle calcium channel. FEBS Lett. 1993 Nov 22; 334(3):261-4. PMID: 8243628.
    Citations: 1     Fields:    Translation:AnimalsCells
  45. Kalasz H, Watanabe T, Yabana H, Itagaki K, Naito K, Nakayama H, Schwartz A, Vaghy PL. Identification of 1,4-dihydropyridine binding domains within the primary structure of the alpha 1 subunit of the skeletal muscle L-type calcium channel. FEBS Lett. 1993 Sep 27; 331(1-2):177-81. PMID: 8405401.
    Citations: 8     Fields:    Translation:Animals
  46. Singer-Lahat D, Lotan I, Itagaki K, Schwartz A, Dascal N. Evidence for the existence of RNA of Ca(2+)-channel alpha 2/delta subunit in Xenopus oocytes. Biochim Biophys Acta. 1992 Oct 06; 1137(1):39-44. PMID: 1382608.
    Citations: 7     Fields:    Translation:AnimalsCells
  47. Klöckner U, Itagaki K, Bodi I, Schwartz A. Beta-subunit expression is required for cAMP-dependent increase of cloned cardiac and vascular calcium channel currents. Pflugers Arch. 1992 Mar; 420(3-4):413-5. PMID: 1317953.
    Citations: 16     Fields:    Translation:AnimalsCells
  48. Itagaki K, Koch WJ, Bodi I, Klöckner U, Slish DF, Schwartz A. Native-type DHP-sensitive calcium channel currents are produced by cloned rat aortic smooth muscle and cardiac alpha 1 subunits expressed in Xenopus laevis oocytes and are regulated by alpha 2- and beta-subunits. FEBS Lett. 1992 Feb 10; 297(3):221-5. PMID: 1371969.
    Citations: 7     Fields:    Translation:AnimalsCells
  49. Vaghy PL, McKenna E, Itagaki K, Schwartz A. Resolution of the identity of the Ca2(+)-antagonist receptor in skeletal muscle. Trends Pharmacol Sci. 1988 Nov; 9(11):398-402. PMID: 2855963.
    Citations: 3     Fields:    Translation:HumansAnimals
  50. Vaghy PL, Itagaki K, Miwa K, McKenna E, Schwartz A. Mechanism of action of calcium channel modulator drugs. Identification of a unique, labile, drug-binding polypeptide in a purified calcium channel preparation. Ann N Y Acad Sci. 1988; 522:176-86. PMID: 2454052.
    Citations: 4     Fields:    Translation:Animals
  51. Vaghy PL, Striessnig J, Miwa K, Knaus HG, Itagaki K, McKenna E, Glossmann H, Schwartz A. Identification of a novel 1,4-dihydropyridine- and phenylalkylamine-binding polypeptide in calcium channel preparations. J Biol Chem. 1987 Oct 15; 262(29):14337-42. PMID: 2443504.
    Citations: 25     Fields:    Translation:AnimalsCells
  52. Fusetani N, Ejima D, Matsunaga S, Hashimoto K, Itagaki K, Akagi Y, Taga N, Suzuki K. 3-Amino-3-deoxy-D-glucose: an antibiotic produced by a deep-sea bacterium. Experientia. 1987 Apr 15; 43(4):464-5. PMID: 3569498.
    Citations: 3     Fields:    Translation:CellsPHPublic Health
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.