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Hiroko Wakimoto, Ph.D., M.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Toepfer CN, Garfinkel AC, Venturini G, Wakimoto H, Repetti G, Alamo L, Sharma A, Agarwal R, Ewoldt JF, Cloonan P, Letendre J, Lun M, Olivotto I, Colan S, Ashley E, Jacoby D, Michels M, Redwood CS, Watkins HC, Day SM, Staples JF, Padrón R, Chopra A, Ho CY, Chen CS, Pereira AC, Seidman JG, Seidman CE. Myosin Sequestration Regulates Sarcomere Function, Cardiomyocyte Energetics, and Metabolism, Informing the Pathogenesis of Hypertrophic Cardiomyopathy. Circulation. 2020 Jan 27. PMID: 31983222.
    Citations:    
  2. Tan CY, Wong JX, Chan PS, Tan H, Liao D, Chen W, Tan LW, Ackers-Johnson M, Wakimoto H, Seidman JG, Seidman CE, Lunde IG, Zhu F, Hu Q, Bian J, Wang JW, Foo RS, Jiang J. Yin Yang 1 Suppresses Dilated Cardiomyopathy and Cardiac Fibrosis Through Regulation of Bmp7 and Ctgf. Circ Res. 2019 Oct 11; 125(9):834-846. PMID: 31495264.
    Citations:    
  3. Ning JF, Stanciu M, Humphrey MR, Gorham J, Wakimoto H, Nishihara R, Lees J, Zou L, Martuza RL, Wakimoto H, Rabkin SD. Myc targeted CDK18 promotes ATR and homologous recombination to mediate PARP inhibitor resistance in glioblastoma. Nat Commun. 2019 07 02; 10(1):2910. PMID: 31266951.
    Citations:    
  4. Garcia-Pavia P, Kim Y, Restrepo-Cordoba MA, Lunde IG, Wakimoto H, Smith AM, Toepfer CN, Getz K, Gorham J, Patel P, Ito K, Willcox JA, Arany Z, Li J, Owens AT, Govind R, Nuñez B, Mazaika E, Bayes-Genis A, Walsh R, Finkelman B, Lupon J, Whiffin N, Serrano I, Midwinter W, Wilk A, Bardaji A, Ingold N, Buchan R, Tayal U, Pascual-Figal DA, de Marvao A, Ahmad M, Garcia-Pinilla JM, Pantazis A, Dominguez F, John Baksi A, O'Regan DP, Rosen SD, Prasad SK, Lara-Pezzi E, Provencio M, Lyon AR, Alonso-Pulpon L, Cook SA, DePalma SR, Barton PJR, Aplenc R, Seidman JG, Ky B, Ware JS, Seidman CE. Genetic Variants Associated With Cancer Therapy-Induced Cardiomyopathy. Circulation. 2019 Jul 02; 140(1):31-41. PMID: 30987448.
    Citations:    
  5. Toepfer CN, Wakimoto H, Garfinkel AC, McDonough B, Liao D, Jiang J, Tai AC, Gorham JM, Lunde IG, Lun M, Lynch TL, McNamara JW, Sadayappan S, Redwood CS, Watkins HC, Seidman JG, Seidman CE. Hypertrophic cardiomyopathy mutations in MYBPC3 dysregulate myosin. Sci Transl Med. 2019 01 23; 11(476). PMID: 30674652.
    Citations:    Fields:    
  6. Schafer S, Viswanathan S, Widjaja AA, Lim WW, Moreno-Moral A, DeLaughter DM, Ng B, Patone G, Chow K, Khin E, Tan J, Chothani SP, Ye L, Rackham OJL, Ko NSJ, Sahib NE, Pua CJ, Zhen NTG, Xie C, Wang M, Maatz H, Lim S, Saar K, Blachut S, Petretto E, Schmidt S, Putoczki T, Guimarães-Camboa N, Wakimoto H, van Heesch S, Sigmundsson K, Lim SL, Soon JL, Chao VTT, Chua YL, Tan TE, Evans SM, Loh YJ, Jamal MH, Ong KK, Chua KC, Ong BH, Chakaramakkil MJ, Seidman JG, Seidman CE, Hubner N, Sin KYK, Cook SA. IL-11 is a crucial determinant of cardiovascular fibrosis. Nature. 2017 12 07; 552(7683):110-115. PMID: 29160304.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  7. Bick AG, Wakimoto H, Kamer KJ, Sancak Y, Goldberger O, Axelsson A, DeLaughter DM, Gorham JM, Mootha VK, Seidman JG, Seidman CE. Cardiovascular homeostasis dependence on MICU2, a regulatory subunit of the mitochondrial calcium uniporter. Proc Natl Acad Sci U S A. 2017 10 24; 114(43):E9096-E9104. PMID: 29073106.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  8. Hinson JT, Chopra A, Lowe A, Sheng CC, Gupta RM, Kuppusamy R, O'Sullivan J, Rowe G, Wakimoto H, Gorham J, Burke MA, Zhang K, Musunuru K, Gerszten RE, Wu SM, Chen CS, Seidman JG, Seidman CE. Integrative Analysis of PRKAG2 Cardiomyopathy iPS and Microtissue Models Identifies AMPK as a Regulator of Metabolism, Survival, and Fibrosis. Cell Rep. 2017 06 13; 19(11):2410. PMID: 28614725.
    Citations: 1     Fields:    
  9. Hulsmans M, Clauss S, Xiao L, Aguirre AD, King KR, Hanley A, Hucker WJ, Wülfers EM, Seemann G, Courties G, Iwamoto Y, Sun Y, Savol AJ, Sager HB, Lavine KJ, Fishbein GA, Capen DE, Da Silva N, Miquerol L, Wakimoto H, Seidman CE, Seidman JG, Sadreyev RI, Naxerova K, Mitchell RN, Brown D, Libby P, Weissleder R, Swirski FK, Kohl P, Vinegoni C, Milan DJ, Ellinor PT, Nahrendorf M. Macrophages Facilitate Electrical Conduction in the Heart. Cell. 2017 04 20; 169(3):510-522.e20. PMID: 28431249.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  10. Hinson JT, Chopra A, Lowe A, Sheng CC, Gupta RM, Kuppusamy R, O'Sullivan J, Rowe G, Wakimoto H, Gorham J, Burke MA, Zhang K, Musunuru K, Gerszten RE, Wu SM, Chen CS, Seidman JG, Seidman CE. Integrative Analysis of PRKAG2 Cardiomyopathy iPS and Microtissue Models Identifies AMPK as a Regulator of Metabolism, Survival, and Fibrosis. Cell Rep. 2016 12 20; 17(12):3292-3304. PMID: 28009297.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  11. DeLaughter DM, Bick AG, Wakimoto H, McKean D, Gorham JM, Kathiriya IS, Hinson JT, Homsy J, Gray J, Pu W, Bruneau BG, Seidman JG, Seidman CE. Single-Cell Resolution of Temporal Gene Expression during Heart Development. Dev Cell. 2016 11 21; 39(4):480-490. PMID: 27840107.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  12. Wakimoto H, Harada K, Arai T, Maeda T, Irisawa R, Tsuboi R. Reduced expression of the ATP2A2 gene in vemurafenib-induced keratoacanthoma-like papules in a melanoma patient. Int J Dermatol. 2017 Feb; 56(2):e33-e35. PMID: 27805257.
    Citations:    Fields:    Translation:Humans
  13. McKean DM, Homsy J, Wakimoto H, Patel N, Gorham J, DePalma SR, Ware JS, Zaidi S, Ma W, Patel N, Lifton RP, Chung WK, Kim R, Shen Y, Brueckner M, Goldmuntz E, Sharp AJ, Seidman CE, Gelb BD, Seidman JG. Loss of RNA expression and allele-specific expression associated with congenital heart disease. Nat Commun. 2016 09 27; 7:12824. PMID: 27670201.
    Citations: 4     Fields:    Translation:Humans
  14. Wakimoto H, Seidman JG, Foo RSY, Jiang J. AAV9 Delivery of shRNA to the Mouse Heart. Curr Protoc Mol Biol. 2016 07 01; 115:23.16.1-23.16.9. PMID: 27366889.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  15. Burke MA, Chang S, Wakimoto H, Gorham JM, Conner DA, Christodoulou DC, Parfenov MG, DePalma SR, Eminaga S, Konno T, Seidman JG, Seidman CE. Molecular profiling of dilated cardiomyopathy that progresses to heart failure. JCI Insight. 2016 May 05; 1(6). PMID: 27239561.
    Citations: 15     Fields:    
  16. Green EM, Wakimoto H, Anderson RL, Evanchik MJ, Gorham JM, Harrison BC, Henze M, Kawas R, Oslob JD, Rodriguez HM, Song Y, Wan W, Leinwand LA, Spudich JA, McDowell RS, Seidman JG, Seidman CE. A small-molecule inhibitor of sarcomere contractility suppresses hypertrophic cardiomyopathy in mice. Science. 2016 Feb 05; 351(6273):617-21. PMID: 26912705.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  17. Homsy J, Zaidi S, Shen Y, Ware JS, Samocha KE, Karczewski KJ, DePalma SR, McKean D, Wakimoto H, Gorham J, Jin SC, Deanfield J, Giardini A, Porter GA, Kim R, Bilguvar K, López-Giráldez F, Tikhonova I, Mane S, Romano-Adesman A, Qi H, Vardarajan B, Ma L, Daly M, Roberts AE, Russell MW, Mital S, Newburger JW, Gaynor JW, Breitbart RE, Iossifov I, Ronemus M, Sanders SJ, Kaltman JR, Seidman JG, Brueckner M, Gelb BD, Goldmuntz E, Lifton RP, Seidman CE, Chung WK. De novo mutations in congenital heart disease with neurodevelopmental and other congenital anomalies. Science. 2015 Dec 04; 350(6265):1262-6. PMID: 26785492.
    Citations: 82     Fields:    Translation:HumansCells
  18. Huang ZP, Kataoka M, Chen J, Wu G, Ding J, Nie M, Lin Z, Liu J, Hu X, Ma L, Zhou B, Wakimoto H, Zeng C, Kyselovic J, Deng ZL, Seidman CE, Seidman JG, Pu WT, Wang DZ. Cardiomyocyte-enriched protein CIP protects against pathophysiological stresses and regulates cardiac homeostasis. J Clin Invest. 2015 Nov 02; 125(11):4122-34. PMID: 26436652.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  19. Chowdhury R, Ashraf H, Melanson M, Tanada Y, Nguyen M, Silberbach M, Wakimoto H, Benson DW, Anderson RH, Kasahara H. Mouse Model of Human Congenital Heart Disease: Progressive Atrioventricular Block Induced by a Heterozygous Nkx2-5 Homeodomain Missense Mutation. Circ Arrhythm Electrophysiol. 2015 Oct; 8(5):1255-64. PMID: 26226998.
    Citations: 3     Fields:    Translation:HumansAnimals
  20. Jiang J, Burgon PG, Wakimoto H, Onoue K, Gorham JM, O'Meara CC, Fomovsky G, McConnell BK, Lee RT, Seidman JG, Seidman CE. Cardiac myosin binding protein C regulates postnatal myocyte cytokinesis. Proc Natl Acad Sci U S A. 2015 Jul 21; 112(29):9046-51. PMID: 26153423.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  21. Wakimoto Y, Jiang J, Wakimoto H. Isolation of single-stranded DNA. Curr Protoc Mol Biol. 2014 Jul 01; 107:2.15.1-9. PMID: 24984851.
    Citations:    Fields:    Translation:Cells
  22. Christodoulou DC, Wakimoto H, Onoue K, Eminaga S, Gorham JM, DePalma SR, Herman DS, Teekakirikul P, Conner DA, McKean DM, Domenighetti AA, Aboukhalil A, Chang S, Srivastava G, McDonough B, De Jager PL, Chen J, Bulyk ML, Muehlschlegel JD, Seidman CE, Seidman JG. 5'RNA-Seq identifies Fhl1 as a genetic modifier in cardiomyopathy. J Clin Invest. 2014 Mar; 124(3):1364-70. PMID: 24509080.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  23. Hölter SM, Stromberg M, Kovalenko M, Garrett L, Glasl L, Lopez E, Guide J, Götz A, Hans W, Becker L, Rathkolb B, Rozman J, Schrewed A, Klingenspor M, Klopstock T, Schulz H, Wolf E, Wursta W, Gillis T, Wakimoto H, Seidman J, MacDonald ME, Cotman S, Gailus-Durner V, Fuchs H, de Angelis MH, Lee JM, Wheeler VC. A broad phenotypic screen identifies novel phenotypes driven by a single mutant allele in Huntington's disease CAG knock-in mice. PLoS One. 2013; 8(11):e80923. PMID: 24278347.
    Citations: 14     Fields:    Translation:AnimalsCells
  24. Jiang J, Wakimoto H, Seidman JG, Seidman CE. Allele-specific silencing of mutant Myh6 transcripts in mice suppresses hypertrophic cardiomyopathy. Science. 2013 Oct 04; 342(6154):111-4. PMID: 24092743.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  25. Hong EG, Kim BW, Jung DY, Kim JH, Yu T, Seixas Da Silva W, Friedline RH, Bianco SD, Seslar SP, Wakimoto H, Berul CI, Russell KS, Lee KW, Larsen PR, Bianco AC, Kim JK. Cardiac expression of human type 2 iodothyronine deiodinase increases glucose metabolism and protects against doxorubicin-induced cardiac dysfunction in male mice. Endocrinology. 2013 Oct; 154(10):3937-46. PMID: 23861374.
    Citations: 10     Fields:    Translation:HumansAnimals
  26. Zaidi S, Choi M, Wakimoto H, Ma L, Jiang J, Overton JD, Romano-Adesman A, Bjornson RD, Breitbart RE, Brown KK, Carriero NJ, Cheung YH, Deanfield J, DePalma S, Fakhro KA, Glessner J, Hakonarson H, Italia MJ, Kaltman JR, Kaski J, Kim R, Kline JK, Lee T, Leipzig J, Lopez A, Mane SM, Mitchell LE, Newburger JW, Parfenov M, Pe'er I, Porter G, Roberts AE, Sachidanandam R, Sanders SJ, Seiden HS, State MW, Subramanian S, Tikhonova IR, Wang W, Warburton D, White PS, Williams IA, Zhao H, Seidman JG, Brueckner M, Chung WK, Gelb BD, Goldmuntz E, Seidman CE, Lifton RP. De novo mutations in histone-modifying genes in congenital heart disease. Nature. 2013 Jun 13; 498(7453):220-3. PMID: 23665959.
    Citations: 207     Fields:    Translation:HumansCells
  27. Lage K, Greenway SC, Rosenfeld JA, Wakimoto H, Gorham JM, Segrè AV, Roberts AE, Smoot LB, Pu WT, Pereira AC, Mesquita SM, Tommerup N, Brunak S, Ballif BC, Shaffer LG, Donahoe PK, Daly MJ, Seidman JG, Seidman CE, Larsen LA. Genetic and environmental risk factors in congenital heart disease functionally converge in protein networks driving heart development. Proc Natl Acad Sci U S A. 2012 Aug 28; 109(35):14035-40. PMID: 22904188.
    Citations: 34     Fields:    Translation:HumansCells
  28. Wakimoto H, Wakimoto Y, Yano H, Matsubara K, Miyakawa S, Yoshida A, Okuzumi K, Sato H, Sawada K, Yamada Y, Futamura M, Kitagawa M, Sato T, Minami M, Hasegawa T. [Antimicrobial susceptibility and serotype distribution in perinatal group B Streptococcus isolates--a 1999-2009 multicenter study]. Kansenshogaku Zasshi. 2011 Mar; 85(2):155-60. PMID: 21560418.
    Citations:    Fields:    Translation:HumansCells
  29. Christodoulou DC, Gorham JM, Kawana M, DePalma SR, Herman DS, Wakimoto H. Quantification of gene transcripts with deep sequencing analysis of gene expression (DSAGE) using 1 to 2 µg total RNA. Curr Protoc Mol Biol. 2011 Jan; Chapter 25:Unit25B.9. PMID: 21225638.
    Citations: 5     Fields:    
  30. Chen PC, Wakimoto H, Conner D, Araki T, Yuan T, Roberts A, Seidman C, Bronson R, Neel B, Seidman JG, Kucherlapati R. Activation of multiple signaling pathways causes developmental defects in mice with a Noonan syndrome–associated Sos1 mutation. J Clin Invest. 2010 Dec; 120(12):4353-65. PMID: 21041952.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  31. Konno T, Chen D, Wang L, Wakimoto H, Teekakirikul P, Nayor M, Kawana M, Eminaga S, Gorham JM, Pandya K, Smithies O, Naya FJ, Olson EN, Seidman JG, Seidman CE. Heterogeneous myocyte enhancer factor-2 (Mef2) activation in myocytes predicts focal scarring in hypertrophic cardiomyopathy. Proc Natl Acad Sci U S A. 2010 Oct 19; 107(42):18097-102. PMID: 20923879.
    Citations: 23     Fields:    Translation:AnimalsCells
  32. Teekakirikul P, Eminaga S, Toka O, Alcalai R, Wang L, Wakimoto H, Nayor M, Konno T, Gorham JM, Wolf CM, Kim JB, Schmitt JP, Molkentin JD, Norris RA, Tager AM, Hoffman SR, Markwald RR, Seidman CE, Seidman JG. Cardiac fibrosis in mice with hypertrophic cardiomyopathy is mediated by non-myocyte proliferation and requires Tgf-ß. J Clin Invest. 2010 Oct; 120(10):3520-9. PMID: 20811150.
    Citations: 137     Fields:    Translation:AnimalsCells
  33. Alcalai R, Wakimoto H, Arad M, Planer D, Konno T, Wang L, Seidman JG, Seidman CE, Berul CI. Prevention of ventricular arrhythmia and calcium dysregulation in a catecholaminergic polymorphic ventricular tachycardia mouse model carrying calsequestrin-2 mutation. J Cardiovasc Electrophysiol. 2011 Mar; 22(3):316-24. PMID: 20807279.
    Citations: 6     Fields:    Translation:AnimalsCells
  34. Lage K, Møllgård K, Greenway S, Wakimoto H, Gorham JM, Workman CT, Bendsen E, Hansen NT, Rigina O, Roque FS, Wiese C, Christoffels VM, Roberts AE, Smoot LB, Pu WT, Donahoe PK, Tommerup N, Brunak S, Seidman CE, Seidman JG, Larsen LA. Dissecting spatio-temporal protein networks driving human heart development and related disorders. Mol Syst Biol. 2010 Jun 22; 6:381. PMID: 20571530.
    Citations: 40     Fields:    Translation:HumansCells
  35. Johnson MD, He L, Herman D, Wakimoto H, Wallace CA, Zidek V, Mlejnek P, Musilova A, Simakova M, Vorlicek J, Kren V, Viklicky O, Qi NR, Wang J, Seidman CE, Seidman J, Kurtz TW, Aitman TJ, Pravenec M. Dissection of chromosome 18 blood pressure and salt-sensitivity quantitative trait loci in the spontaneously hypertensive rat. Hypertension. 2009 Sep; 54(3):639-45. PMID: 19620519.
    Citations: 7     Fields:    Translation:AnimalsCells
  36. Takeda M, Briggs LE, Wakimoto H, Marks MH, Warren SA, Lu JT, Weinberg EO, Robertson KD, Chien KR, Kasahara H. Slow progressive conduction and contraction defects in loss of Nkx2-5 mice after cardiomyocyte terminal differentiation. Lab Invest. 2009 Sep; 89(9):983-93. PMID: 19546853.
    Citations: 19     Fields:    Translation:AnimalsCells
  37. Mobine HR, Baker AB, Wang L, Wakimoto H, Jacobsen KC, Seidman CE, Seidman JG, Edelman ER. Pheochromocytoma-induced cardiomyopathy is modulated by the synergistic effects of cell-secreted factors. Circ Heart Fail. 2009 Mar; 2(2):121-8. PMID: 19808327.
    Citations: 4     Fields:    Translation:AnimalsCells
  38. Briggs LE, Takeda M, Cuadra AE, Wakimoto H, Marks MH, Walker AJ, Seki T, Oh SP, Lu JT, Sumners C, Raizada MK, Horikoshi N, Weinberg EO, Yasui K, Ikeda Y, Chien KR, Kasahara H. Perinatal loss of Nkx2-5 results in rapid conduction and contraction defects. Circ Res. 2008 Sep 12; 103(6):580-90. PMID: 18689573.
    Citations: 33     Fields:    Translation:Animals
  39. Wakimoto H, Ogura M, Yano H, Koguchi A, Wakimoto Y, Miyakawa S, Doi M, Okuzumi K, Mizokami M. Pulsed field gel electrophoresis analysis conditions for molecular epidemiological group B streptococcus identification. Kansenshogaku Zasshi. 2008 Jul; 82(4):351-3. PMID: 18800408.
    Citations:    Fields:    Translation:HumansCells
  40. Wolf CM, Wang L, Alcalai R, Pizard A, Burgon PG, Ahmad F, Sherwood M, Branco DM, Wakimoto H, Fishman GI, See V, Stewart CL, Conner DA, Berul CI, Seidman CE, Seidman JG. Lamin A/C haploinsufficiency causes dilated cardiomyopathy and apoptosis-triggered cardiac conduction system disease. J Mol Cell Cardiol. 2008 Feb; 44(2):293-303. PMID: 18182166.
    Citations: 46     Fields:    Translation:AnimalsCells
  41. Luptak I, Shen M, He H, Hirshman MF, Musi N, Goodyear LJ, Yan J, Wakimoto H, Morita H, Arad M, Seidman CE, Seidman JG, Ingwall JS, Balschi JA, Tian R. Aberrant activation of AMP-activated protein kinase remodels metabolic network in favor of cardiac glycogen storage. J Clin Invest. 2007 May; 117(5):1432-9. PMID: 17431505.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  42. Terada K, Wakimoto H, Tyminski E, Chiocca EA, Saeki Y. Development of a rapid method to generate multiple oncolytic HSV vectors and their in vivo evaluation using syngeneic mouse tumor models. Gene Ther. 2006 Apr; 13(8):705-14. PMID: 16421599.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  43. Wakimoto H, Yano H, Baba S, Okuzumi K, Okamoto N, Wakimoto Y, Miyakawa S, Mizokami M. Pulsed field gel electrophoresis analysis conditions for molecular epidemiological identification of vertical Group B Streptococcus infection. Kansenshogaku Zasshi. 2005 Aug; 79(8):561-3. PMID: 16167788.
    Citations:    Fields:    Translation:HumansCells
  44. Wakimoto H, Yano H, Baba S, Okuzumi K, Okamoto N, Wakimoto Y, Miyakawa S, Mizokami M. [Prevention of vertical transmission of Group B Streptococcus]. Kansenshogaku Zasshi. 2005 Aug; 79(8):549-55. PMID: 16167786.
    Citations: 1     Fields:    Translation:HumansCells
  45. Jay PY, Maguire CT, Wakimoto H, Izumo S, Berul CI. Absence of Msx2 does not affect cardiac conduction or rescue conduction defects associated with Nkx2-5 mutation. J Cardiovasc Electrophysiol. 2005 Jan; 16(1):82-5. PMID: 15673394.
    Citations: 2     Fields:    Translation:Animals
  46. Izumida N, Asano Y, Doi S, Wakimoto H, Fukamizu S, Kimura T, Ueyama T, Sakurada H, Kawano S, Sawanobori T, Hiraoka M. Changes in body surface potential distributions induced by isoproterenol and Na channel blockers in patients with the Brugada syndrome. Int J Cardiol. 2004 Jun; 95(2-3):261-8. PMID: 15193830.
    Citations: 3     Fields:    Translation:Humans
  47. Jay PY, Harris BS, Maguire CT, Buerger A, Wakimoto H, Tanaka M, Kupershmidt S, Roden DM, Schultheiss TM, O'Brien TX, Gourdie RG, Berul CI, Izumo S. Nkx2-5 mutation causes anatomic hypoplasia of the cardiac conduction system. J Clin Invest. 2004 Apr; 113(8):1130-7. PMID: 15085192.
    Citations: 69     Fields:    Translation:Animals
  48. Wakimoto H, Fulci G, Tyminski E, Chiocca EA. Altered expression of antiviral cytokine mRNAs associated with cyclophosphamide's enhancement of viral oncolysis. Gene Ther. 2004 Jan; 11(2):214-23. PMID: 14712306.
    Citations: 49     Fields:    Translation:AnimalsCells
  49. Wakimoto H, Kasahara H, Maguire CT, Moskowitz IP, Izumo S, Berul CI. Cardiac electrophysiological phenotypes in postnatal expression of Nkx2.5 transgenic mice. Genesis. 2003 Nov; 37(3):144-50. PMID: 14595838.
    Citations: 3     Fields:    Translation:AnimalsCells
  50. Maguire CT, Wakimoto H, Patel VV, Hammer PE, Gauvreau K, Berul CI. Implications of ventricular arrhythmia vulnerability during murine electrophysiology studies. Physiol Genomics. 2003 Sep 29; 15(1):84-91. PMID: 12888626.
    Citations: 24     Fields:    Translation:Animals
  51. Donoghue M, Wakimoto H, Maguire CT, Acton S, Hales P, Stagliano N, Fairchild-Huntress V, Xu J, Lorenz JN, Kadambi V, Berul CI, Breitbart RE. Heart block, ventricular tachycardia, and sudden death in ACE2 transgenic mice with downregulated connexins. J Mol Cell Cardiol. 2003 Sep; 35(9):1043-53. PMID: 12967627.
    Citations: 32     Fields:    Translation:AnimalsCells
  52. Deisboeck TS, Wakimoto H, Nestler U, Louis DN, Sehgal PK, Simon M, Chiocca EA, Hochberg FH. Development of a novel non-human primate model for preclinical gene vector safety studies. Determining the effects of intracerebral HSV-1 inoculation in the common marmoset: a comparative study. Gene Ther. 2003 Aug; 10(15):1225-33. PMID: 12858187.
    Citations: 5     Fields:    Translation:AnimalsCells
  53. Wakimoto H, Johnson PR, Knipe DM, Chiocca EA. Effects of innate immunity on herpes simplex virus and its ability to kill tumor cells. Gene Ther. 2003 Jun; 10(11):983-90. PMID: 12756419.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  54. Mitaka C, Hirata Y, Yokoyama K, Wakimoto H, Hirokawa M, Nosaka T, Imai T. Relationships of circulating nitrite/nitrate levels to severity and multiple organ dysfunction syndrome in systemic inflammatory response syndrome. Shock. 2003 Apr; 19(4):305-9. PMID: 12688539.
    Citations: 10     Fields:    Translation:Humans
  55. Kasahara H, Ueyama T, Wakimoto H, Liu MK, Maguire CT, Converso KL, Kang PM, Manning WJ, Lawitts J, Paul DL, Berul CI, Izumo S. Nkx2.5 homeoprotein regulates expression of gap junction protein connexin 43 and sarcomere organization in postnatal cardiomyocytes. J Mol Cell Cardiol. 2003 Mar; 35(3):243-56. PMID: 12676539.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  56. Wakimoto H, Maguire CT, Sherwood MC, Vargas MM, Sarkar PS, Han J, Reddy S, Berul CI. Characterization of cardiac conduction system abnormalities in mice with targeted disruption of Six5 gene. J Interv Card Electrophysiol. 2002 Oct; 7(2):127-35. PMID: 12397222.
    Citations: 14     Fields:    Translation:Animals
  57. Wakimoto H, Kasahara H, Maguire CT, Izumo S, Berul CI. Developmentally modulated cardiac conduction failure in transgenic mice with fetal or postnatal overexpression of DNA nonbinding mutant Nkx2.5. J Cardiovasc Electrophysiol. 2002 Jul; 13(7):682-8. PMID: 12139292.
    Citations: 7     Fields:    Translation:AnimalsCells
  58. Tanaka M, Berul CI, Ishii M, Jay PY, Wakimoto H, Douglas P, Yamasaki N, Kawamoto T, Gehrmann J, Maguire CT, Schinke M, Seidman CE, Seidman JG, Kurachi Y, Izumo S. A mouse model of congenital heart disease: cardiac arrhythmias and atrial septal defect caused by haploinsufficiency of the cardiac transcription factor Csx/Nkx2.5. Cold Spring Harb Symp Quant Biol. 2002; 67:317-25. PMID: 12858555.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  59. Berul CI, McConnell BK, Wakimoto H, Moskowitz IP, Maguire CT, Semsarian C, Vargas MM, Gehrmann J, Seidman CE, Seidman JG. Ventricular arrhythmia vulnerability in cardiomyopathic mice with homozygous mutant Myosin-binding protein C gene. Circulation. 2001 Nov 27; 104(22):2734-9. PMID: 11723028.
    Citations: 14     Fields:    Translation:Animals
  60. Rakhit A, Maguire CT, Wakimoto H, Gehrmann J, Li GK, Kelly RA, Michel T, Berul CI. In vivo electrophysiologic studies in endothelial nitric oxide synthase (eNOS)-deficient mice. J Cardiovasc Electrophysiol. 2001 Nov; 12(11):1295-301. PMID: 11761419.
    Citations: 11     Fields:    Translation:Animals
  61. Kasahara H, Wakimoto H, Liu M, Maguire CT, Converso KL, Shioi T, Huang WY, Manning WJ, Paul D, Lawitts J, Berul CI, Izumo S. Progressive atrioventricular conduction defects and heart failure in mice expressing a mutant Csx/Nkx2.5 homeoprotein. J Clin Invest. 2001 Jul; 108(2):189-201. PMID: 11457872.
    Citations: 34     Fields:    Translation:AnimalsCells
  62. Wakimoto H, Maguire CT, Kovoor P, Hammer PE, Gehrmann J, Triedman JK, Berul CI. Induction of atrial tachycardia and fibrillation in the mouse heart. Cardiovasc Res. 2001 Jun; 50(3):463-73. PMID: 11376622.
    Citations: 23     Fields:    Translation:Animals
  63. Gehrmann J, Frantz S, Maguire CT, Vargas M, Ducharme A, Wakimoto H, Lee RT, Berul CI. Electrophysiological characterization of murine myocardial ischemia and infarction. Basic Res Cardiol. 2001 May-Jun; 96(3):237-50. PMID: 11403417.
    Citations: 15     Fields:    Translation:Animals
  64. Nagashima G, Aoyagi M, Yamamoto S, Wakimoto H, Tamaki M, Yamamoto K, Fujimoto T, Hirakawa K. Involvement of disregulated c-myc but not c-sis/PDGF in atypical and anaplastic meningiomas. Clin Neurol Neurosurg. 2001 Apr; 103(1):13-8. PMID: 11311470.
    Citations: 1     Fields:    Translation:Humans
  65. McConnell BK, Fatkin D, Semsarian C, Jones KA, Georgakopoulos D, Maguire CT, Healey MJ, Mudd JO, Moskowitz IP, Conner DA, Giewat M, Wakimoto H, Berul CI, Schoen FJ, Kass DA, Seidman CE, Seidman JG. Comparison of two murine models of familial hypertrophic cardiomyopathy. Circ Res. 2001 Mar 02; 88(4):383-9. PMID: 11230104.
    Citations: 33     Fields:    Translation:AnimalsCells
  66. Bevilacqua LM, Simon AM, Maguire CT, Gehrmann J, Wakimoto H, Paul DL, Berul CI. A targeted disruption in connexin40 leads to distinct atrioventricular conduction defects. J Interv Card Electrophysiol. 2000 Oct; 4(3):459-67. PMID: 11046183.
    Citations: 16     Fields:    Translation:AnimalsCells
  67. Gehrmann J, Hammer PE, Maguire CT, Wakimoto H, Triedman JK, Berul CI. Phenotypic screening for heart rate variability in the mouse. Am J Physiol Heart Circ Physiol. 2000 Aug; 279(2):H733-40. PMID: 10924073.
    Citations: 57     Fields:    Translation:HumansAnimals
  68. Izumida N, Asano Y, Wakimoto H, Nishiyama M, Doi S, Tsuchiya S, Hosaki J, Kawano S, Sawanobori T, Hiraoka M. Analysis of T wave changes by activation recovery interval in patients with atrial septal defect. Int J Cardiol. 2000 Jul 31; 74(2-3):115-24. PMID: 10962110.
    Citations:    Fields:    Translation:HumansCTClinical Trials
  69. Maguire CT, Bevilacqua LM, Wakimoto H, Gehrmann J, Berul CI. Maturational atrioventricular nodal physiology in the mouse. J Cardiovasc Electrophysiol. 2000 May; 11(5):557-64. PMID: 10826935.
    Citations: 6     Fields:    Translation:Animals
  70. Ikeda K, Wakimoto H, Ichikawa T, Jhung S, Hochberg FH, Louis DN, Chiocca EA. Complement depletion facilitates the infection of multiple brain tumors by an intravascular, replication-conditional herpes simplex virus mutant. J Virol. 2000 May; 74(10):4765-75. PMID: 10775615.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  71. Wakimoto H, Izumida N, Asano Y, Hiraoka M, Kawara T, Hiejima K, Hirao TK, Suzuki F. Augmentation of QRS wave amplitudes in the precordial leads during narrow QRS tachycardia. J Cardiovasc Electrophysiol. 2000 Jan; 11(1):52-60. PMID: 10695462.
    Citations:    Fields:    Translation:Humans
  72. Ikeda K, Ichikawa T, Wakimoto H, Silver JS, Deisboeck TS, Finkelstein D, Harsh GR, Louis DN, Bartus RT, Hochberg FH, Chiocca EA. Oncolytic virus therapy of multiple tumors in the brain requires suppression of innate and elicited antiviral responses. Nat Med. 1999 Aug; 5(8):881-7. PMID: 10426310.
    Citations: 104     Fields:    Translation:HumansAnimalsCells
  73. Nagashima G, Aoyagi M, Yamamoto M, Yamamoto S, Wakimoto H, Ohno K, Yamamoto K, Hirakawa K. P53 overexpression and proliferative potential in malignant meningiomas. Acta Neurochir (Wien). 1999; 141(1):53-61; discussion 60-1. PMID: 10071687.
    Citations: 3     Fields:    Translation:Humans
  74. Hara M, Aoyagi M, Nagashima G, Wakimoto H, Mikami T, Yamamoto S, Tamaki M, Hirakawa K. Recurrence in meningeal hemangiopericytomas. Surg Neurol. 1998 Dec; 50(6):586-91. PMID: 9870821.
    Citations: 4     Fields:    Translation:Humans
  75. Takada Y, Ohno K, Wakimoto H, Hirakawa K. Treatment of intracranial abscess in the era of neuroimaging: an analysis of 13 consecutive cases. J Med Dent Sci. 1998 Jun; 45(2):69-76. PMID: 11186202.
    Citations:    Fields:    Translation:Humans
  76. Izumida N, Asano Y, Kiyohara K, Doi S, Wakimoto H, Tsuchiya S, Hosaki J, Kawano S, Sawanobori T, Hiraoka M. Precordial leads QRST time integrals for evaluation of right ventricular overload in children with congenital heart diseases. J Electrocardiol. 1997 Jul; 30(3):257-64. PMID: 9261734.
    Citations:    Fields:    Translation:Humans
  77. Kanai F, Lan KH, Shiratori Y, Tanaka T, Ohashi M, Okudaira T, Yoshida Y, Wakimoto H, Hamada H, Nakabayashi H, Tamaoki T, Omata M. In vivo gene therapy for alpha-fetoprotein-producing hepatocellular carcinoma by adenovirus-mediated transfer of cytosine deaminase gene. Cancer Res. 1997 Feb 01; 57(3):461-5. PMID: 9012474.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  78. Tanaka T, Kanai F, Okabe S, Yoshida Y, Wakimoto H, Hamada H, Shiratori Y, Lan K, Ishitobi M, Omata M. Adenovirus-mediated prodrug gene therapy for carcinoembryonic antigen-producing human gastric carcinoma cells in vitro. Cancer Res. 1996 Mar 15; 56(6):1341-5. PMID: 8640823.
    Citations: 18     Fields:    Translation:HumansCells
  79. Wakimoto H, Aoyagi M, Nakayama T, Nagashima G, Yamamoto S, Tamaki M, Hirakawa K. Prognostic significance of Ki-67 labeling indices obtained using MIB-1 monoclonal antibody in patients with supratentorial astrocytomas. Cancer. 1996 Jan 15; 77(2):373-80. PMID: 8625247.
    Citations: 39     Fields:    Translation:Humans
  80. Aoyagi M, Yamamoto M, Wakimoto H, Azuma H, Hirakawa K, Yamamoto K. Immunohistochemical detection of Ki-67 in replicative smooth muscle cells of rabbit carotid arteries after balloon denudation. Stroke. 1995 Dec; 26(12):2328-31; discussion 2331-2. PMID: 7491659.
    Citations: 2     Fields:    Translation:Animals
  81. Nagashima G, Aoyagi M, Wakimoto H, Tamaki M, Ohno K, Hirakawa K. Immunohistochemical detection of progesterone receptors and the correlation with Ki-67 labeling indices in paraffin-embedded sections of meningiomas. Neurosurgery. 1995 Sep; 37(3):478-82; discussion 483. PMID: 7501113.
    Citations: 8     Fields:    Translation:Humans
  82. Abe J, Wakimoto H, Yoshida Y, Aoyagi M, Hirakawa K, Hamada H. Antitumor effect induced by granulocyte/macrophage-colony-stimulating factor gene-modified tumor vaccination: comparison of adenovirus- and retrovirus-mediated genetic transduction. J Cancer Res Clin Oncol. 1995; 121(9-10):587-92. PMID: 7559742.
    Citations: 7     Fields:    Translation:AnimalsCellsPHPublic Health
  83. Kouji T, Kohyama J, Shimohira M, Iwakawa Y, Araki S, Wakimoto H, Tsuchiya S. Polysomnographical study in the patients of frontal lobe epilepsy with ictal automatism. Jpn J Psychiatry Neurol. 1993 Jun; 47(2):339-41. PMID: 8271587.
    Citations:    Fields:    Translation:Humans
  84. Komura H, Wakimoto H, Chen CF, Terakawa N, Aono T, Tanizawa O, Matsumoto K. Retinoic acid enhances cell responses to epidermal growth factor in mouse mammary gland in culture. Endocrinology. 1986 Apr; 118(4):1530-6. PMID: 3512256.
    Citations: 3     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.