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Daryush Mehta, Ph.D.

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  1. R21DC015877 (MEHTA, DARYUSH DINYAR) Jan 6, 2017 - Dec 31, 2019
    NIH
    Non-invasive estimation of subglottal pressure during natural speech to improve clinical voice assessment
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Toles LE, Ortiz AJ, Marks KL, Burns JA, Hron T, Van Stan JH, Mehta DD, Hillman RE. Differences Between Female Singers With Phonotrauma and Vocally Healthy Matched Controls in Singing and Speaking Voice Use During 1 Week of Ambulatory Monitoring. Am J Speech Lang Pathol. 2021 01 27; 30(1):199-209. PMID: 33472007.
    Citations:    Fields:    
  2. Ghasemzadeh H, Deliyski DD, Hillman RE, Mehta DD. Method for Horizontal Calibration of Laser-Projection Transnasal Fiberoptic High-Speed Videoendoscopy. Appl Sci (Basel). 2021 Jan 02; 11(2). PMID: 33628469.
    Citations:    
  3. Van Stan JH, Mehta DD, Ortiz AJ, Burns JA, Marks KL, Toles LE, Stadelman-Cohen T, Krusemark C, Muise J, Hron T, Zeitels SM, Fox AB, Hillman RE. Changes in a Daily Phonotrauma Index After Laryngeal Surgery and Voice Therapy: Implications for the Role of Daily Voice Use in the Etiology and Pathophysiology of Phonotraumatic Vocal Hyperfunction. J Speech Lang Hear Res. 2020 12 14; 63(12):3934-3944. PMID: 33197360.
    Citations:    Fields:    
  4. Burckardt ES, Hillman RE, Murton O, Mehta D, Van Stan J, Burns JA. The Impact of Tonsillectomy on the Adult Singing Voice: Acoustic and Aerodynamic Measures. J Voice. 2020 Oct 31. PMID: 33143998.
    Citations:    Fields:    
  5. Hillman RE, Stepp CE, Van Stan JH, Zañartu M, Mehta DD. An Updated Theoretical Framework for Vocal Hyperfunction. Am J Speech Lang Pathol. 2020 11 12; 29(4):2254-2260. PMID: 33007164.
    Citations:    Fields:    
  6. Espinoza VM, Mehta DD, Van Stan JH, Hillman RE, Zañartu M. Glottal Aerodynamics Estimated From Neck-Surface Vibration in Women With Phonotraumatic and Nonphonotraumatic Vocal Hyperfunction. J Speech Lang Hear Res. 2020 09 15; 63(9):2861-2869. PMID: 32755502.
    Citations:    Fields:    
  7. Murton O, Hillman R, Mehta D. Cepstral Peak Prominence Values for Clinical Voice Evaluation. Am J Speech Lang Pathol. 2020 08 04; 29(3):1596-1607. PMID: 32658592.
    Citations: 2     Fields:    
  8. Groll MD, Vojtech JM, Hablani S, Mehta DD, Buckley DP, Noordzij JP, Stepp CE. Automated Relative Fundamental Frequency Algorithms for Use With Neck-Surface Accelerometer Signals. J Voice. 2020 Jul 08. PMID: 32653267.
    Citations:    Fields:    
  9. Rao HM, Smalt CJ, Rodriguez A, Wright HM, Mehta DD, Brattain LJ, Edwards HM, Lammert A, Heaton KJ, Quatieri TF. Predicting Cognitive Load and Operational Performance in a Simulated Marksmanship Task. Front Hum Neurosci. 2020; 14:222. PMID: 32719593.
    Citations:    
  10. Marks KL, Lin JZ, Burns JA, Hron TA, Hillman RE, Mehta DD. Estimation of Subglottal Pressure From Neck Surface Vibration in Patients With Voice Disorders. J Speech Lang Hear Res. 2020 07 20; 63(7):2202-2218. PMID: 32610028.
    Citations:    Fields:    
  11. Whittico TH, Ortiz AJ, Marks KL, Toles LE, Van Stan JH, Hillman RE, Mehta DD. Ambulatory monitoring of Lombard-related vocal characteristics in vocally healthy female speakers. J Acoust Soc Am. 2020 06; 147(6):EL552. PMID: 32611177.
    Citations:    Fields:    
  12. Toles LE, Ortiz AJ, Marks KL, Mehta DD, Van Stan JH, Hillman RE. Amount and Characteristics of Speaking and Singing Voice Use in Vocally Healthy Female College Student Singers During a Typical Week. J Voice. 2020 May 22. PMID: 32451254.
    Citations:    Fields:    
  13. Alzamendi GA, Manríquez R, Hadwin PJ, Deng JJ, Peterson SD, Erath BD, Mehta DD, Hillman RE, Zañartu M. Bayesian estimation of vocal function measures using laryngeal high-speed videoendoscopy and glottal airflow estimates: An in vivo case study. J Acoust Soc Am. 2020 05; 147(5):EL434. PMID: 32486812.
    Citations: 1     Fields:    
  14. Van Stan JH, Mehta DD, Ortiz AJ, Burns JA, Toles LE, Marks KL, Vangel M, Hron T, Zeitels S, Hillman RE. Differences in Weeklong Ambulatory Vocal Behavior Between Female Patients With Phonotraumatic Lesions and Matched Controls. J Speech Lang Hear Res. 2020 02 26; 63(2):372-384. PMID: 31995428.
    Citations: 5     Fields:    
  15. Brockmann-Bauser M, Van Stan JH, Carvalho Sampaio M, Bohlender JE, Hillman RE, Mehta DD. Effects of Vocal Intensity and Fundamental Frequency on Cepstral Peak Prominence in Patients with Voice Disorders and Vocally Healthy Controls. J Voice. 2019 Dec 16. PMID: 31859213.
    Citations: 2     Fields:    
  16. Heaton JT, Kobler JB, Ottensmeyer MP, Petrillo RH, Tynan MA, Mehta DD, Hillman RE, Zeitels SM. Aerodynamically driven phonation of individual vocal folds under general anesthesia in canines. Laryngoscope. 2020 08; 130(8):1980-1988. PMID: 31603575.
    Citations:    Fields:    Translation:Animals
  17. Marks KL, Lin JZ, Fox AB, Toles LE, Mehta DD. Impact of Nonmodal Phonation on Estimates of Subglottal Pressure From Neck-Surface Acceleration in Healthy Speakers. J Speech Lang Hear Res. 2019 09 20; 62(9):3339-3358. PMID: 31518510.
    Citations: 2     Fields:    Translation:Humans
  18. Maguluri G, Mehta D, Kobler J, Park J, Iftimia N. Synchronized, concurrent optical coherence tomography and videostroboscopy for monitoring vocal fold morphology and kinematics. Biomed Opt Express. 2019 Sep 01; 10(9):4450-4461. PMID: 31565501.
    Citations: 1     
  19. Deliyski DD, Shishkov M, Mehta DD, Ghasemzadeh H, Bouma B, Zañartu M, de Alarcon A, Hillman RE. Laser-Calibrated System for Transnasal Fiberoptic Laryngeal High-Speed Videoendoscopy. J Voice. 2021 Jan; 35(1):122-128. PMID: 31383516.
    Citations: 2     Fields:    
  20. Motie-Shirazi M, Zañartu M, Peterson SD, Mehta DD, Kobler JB, Hillman RE, Erath BD. Toward Development of a Vocal Fold Contact Pressure Probe: Sensor Characterization and Validation Using Synthetic Vocal Fold Models. Appl Sci (Basel). 2019 Aug; 9(15). PMID: 32377408.
    Citations: 2     
  21. Whitfield JA, Kriegel Z, Fullenkamp AM, Mehta DD. Effects of Concurrent Manual Task Performance on Connected Speech Acoustics in Individuals With Parkinson Disease. J Speech Lang Hear Res. 2019 07 15; 62(7):2099-2117. PMID: 31306612.
    Citations:    Fields:    Translation:Humans
  22. Whitfield JA, Mehta DD. Examination of Clear Speech in Parkinson Disease Using Measures of Working Vowel Space. J Speech Lang Hear Res. 2019 07 15; 62(7):2082-2098. PMID: 31306606.
    Citations:    Fields:    Translation:Humans
  23. Ortiz AJ, Toles LE, Marks KL, Capobianco S, Mehta DD, Hillman RE, Van Stan JH. Automatic speech and singing classification in ambulatory recordings for normal and disordered voices. J Acoust Soc Am. 2019 07; 146(1):EL22. PMID: 31370647.
    Citations: 4     Fields:    Translation:Humans
  24. Ghasemzadeh H, Deliyski DD, Ford DS, Kobler JB, Hillman RE, Mehta DD. Method for Vertical Calibration of Laser-Projection Transnasal Fiberoptic High-Speed Videoendoscopy. J Voice. 2020 Nov; 34(6):847-861. PMID: 31151853.
    Citations: 3     Fields:    
  25. Mehta DD, Espinoza VM, Van Stan JH, Zañartu M, Hillman RE. The difference between first and second harmonic amplitudes correlates between glottal airflow and neck-surface accelerometer signals during phonation. J Acoust Soc Am. 2019 05; 145(5):EL386. PMID: 31153299.
    Citations: 5     Fields:    Translation:Humans
  26. Murton O, Shattuck-Hufnagel S, Choi JY, Mehta DD. Identifying a creak probability threshold for an irregular pitch period detection algorithm. J Acoust Soc Am. 2019 05; 145(5):EL379. PMID: 31153305.
    Citations:    Fields:    Translation:Humans
  27. Powell ME, Deliyski DD, Zeitels SM, Burns JA, Hillman RE, Gerlach TT, Mehta DD. Efficacy of Videostroboscopy and High-Speed Videoendoscopy to Obtain Functional Outcomes From Perioperative Ratings in Patients With Vocal Fold Mass Lesions. J Voice. 2020 Sep; 34(5):769-782. PMID: 31005449.
    Citations: 3     Fields:    
  28. Cortés JP, Espinoza VM, Ghassemi M, Mehta DD, Van Stan JH, Hillman RE, Guttag JV, Zañartu M. Ambulatory assessment of phonotraumatic vocal hyperfunction using glottal airflow measures estimated from neck-surface acceleration. PLoS One. 2018; 13(12):e0209017. PMID: 30571719.
    Citations: 5     Fields:    Translation:Humans
  29. McKenna VS, Llico AF, Mehta DD, Perkell JS, Stepp CE. Magnitude of Neck-Surface Vibration as an Estimate of Subglottal Pressure During Modulations of Vocal Effort and Intensity in Healthy Speakers. J Speech Lang Hear Res. 2017 12 20; 60(12):3404-3416. PMID: 29204608.
    Citations: 5     Fields:    Translation:Humans
  30. Borsky M, Mehta DD, Van Stan JH, Gudnason J. Modal and non-modal voice quality classification using acoustic and electroglottographic features. IEEE/ACM Trans Audio Speech Lang Process. 2017 Dec; 25(12):2281-2291. PMID: 33748320.
    Citations:    
  31. Van Stan JH, Maffei M, Masson MLV, Mehta DD, Burns JA, Hillman RE. Self-Ratings of Vocal Status in Daily Life: Reliability and Validity for Patients With Vocal Hyperfunction and a Normative Group. Am J Speech Lang Pathol. 2017 Nov 08; 26(4):1167-1177. PMID: 29086800.
    Citations: 2     Fields:    Translation:Humans
  32. Murton OM, Hillman RE, Mehta DD, Semigran M, Daher M, Cunningham T, Verkouw K, Tabtabai S, Steiner J, Dec GW, Ausiello D. Acoustic speech analysis of patients with decompensated heart failure: A pilot study. J Acoust Soc Am. 2017 10; 142(4):EL401. PMID: 29092550.
    Citations: 4     Fields:    Translation:Humans
  33. Van Stan JH, Park SW, Jarvis M, Mehta DD, Hillman RE, Sternad D. Measuring vocal motor skill with a virtual voice-controlled slingshot. J Acoust Soc Am. 2017 09; 142(3):1199. PMID: 28964079.
    Citations:    Fields:    Translation:Humans
  34. Lien YS, Heller Murray ES, Calabrese CR, Michener CM, Van Stan JH, Mehta DD, Hillman RE, Noordzij JP, Stepp CE. Validation of an Algorithm for Semi-automated Estimation of Voice Relative Fundamental Frequency. Ann Otol Rhinol Laryngol. 2017 Oct; 126(10):712-716. PMID: 28849664.
    Citations: 5     Fields:    Translation:Humans
  35. Espinoza VM, Zañartu M, Van Stan JH, Mehta DD, Hillman RE. Glottal Aerodynamic Measures in Women With Phonotraumatic and Nonphonotraumatic Vocal Hyperfunction. J Speech Lang Hear Res. 2017 08 16; 60(8):2159-2169. PMID: 28785762.
    Citations: 11     Fields:    Translation:Humans
  36. Heller Murray ES, Lien YS, Van Stan JH, Mehta DD, Hillman RE, Pieter Noordzij J, Stepp CE. Relative Fundamental Frequency Distinguishes Between Phonotraumatic and Non-Phonotraumatic Vocal Hyperfunction. J Speech Lang Hear Res. 2017 06 10; 60(6):1507-1515. PMID: 28595317.
    Citations: 7     Fields:    Translation:Humans
  37. Van Stan JH, Mehta DD, Sternad D, Petit R, Hillman RE. Ambulatory Voice Biofeedback: Relative Frequency and Summary Feedback Effects on Performance and Retention of Reduced Vocal Intensity in the Daily Lives of Participants With Normal Voices. J Speech Lang Hear Res. 2017 04 14; 60(4):853-864. PMID: 28329366.
    Citations: 6     Fields:    Translation:HumansPHPublic Health
  38. Van Stan JH, Mehta DD, Petit RJ, Sternad D, Muise J, Burns JA, Hillman RE. Integration of Motor Learning Principles Into Real-Time Ambulatory Voice Biofeedback and Example Implementation Via a Clinical Case Study With Vocal Fold Nodules. Am J Speech Lang Pathol. 2017 Feb 01; 26(1):1-10. PMID: 28124070.
    Citations: 6     Fields:    Translation:Humans
  39. Fryd AS, Van Stan JH, Hillman RE, Mehta DD. Estimating Subglottal Pressure From Neck-Surface Acceleration During Normal Voice Production. J Speech Lang Hear Res. 2016 12 01; 59(6):1335-1345. PMID: 27959974.
    Citations: 8     Fields:    Translation:Humans
  40. Powell ME, Deliyski DD, Hillman RE, Zeitels SM, Burns JA, Mehta DD. Comparison of Videostroboscopy to Stroboscopy Derived From High-Speed Videoendoscopy for Evaluating Patients With Vocal Fold Mass Lesions. Am J Speech Lang Pathol. 2016 11 01; 25(4):576-589. PMID: 27716854.
    Citations: 4     Fields:    Translation:Humans
  41. Mehta DD, Cheyne HA, Wehner A, Heaton JT, Hillman RE. Accuracy of Self-Reported Estimates of Daily Voice Use in Adults With Normal and Disordered Voices. Am J Speech Lang Pathol. 2016 11 01; 25(4):634-641. PMID: 27788279.
    Citations: 3     Fields:    Translation:Humans
  42. Mehta DD, Van Stan JH, Hillman RE. Relationships between vocal function measures derived from an acoustic microphone and a subglottal neck-surface accelerometer. IEEE/ACM Trans Audio Speech Lang Process. 2016 Apr; 24(4):659-668. PMID: 27066520.
    Citations: 15     
  43. Mehta DD, Van Stan JH, Zañartu M, Ghassemi M, Guttag JV, Espinoza VM, Cortés JP, Cheyne HA, Hillman RE. Using Ambulatory Voice Monitoring to Investigate Common Voice Disorders: Research Update. Front Bioeng Biotechnol. 2015; 3:155. PMID: 26528472.
    Citations: 24     
  44. Lien YA, Calabrese CR, Michener CM, Murray EH, Van Stan JH, Mehta DD, Hillman RE, Noordzij JP, Stepp CE. Voice Relative Fundamental Frequency Via Neck-Skin Acceleration in Individuals With Voice Disorders. J Speech Lang Hear Res. 2015 Oct; 58(5):1482-7. PMID: 26134171.
    Citations: 5     Fields:    Translation:Humans
  45. Deliyski DD, Hillman RE, Mehta DD. Laryngeal High-Speed Videoendoscopy: Rationale and Recommendation for Accurate and Consistent Terminology. J Speech Lang Hear Res. 2015 Oct; 58(5):1488-92. PMID: 26375398.
    Citations: 3     Fields:    Translation:Humans
  46. Ghassemi M, Van Stan JH, Mehta DD, Zañartu M, Cheyne HA, Hillman RE, Guttag JV. Corrections to "Learning to Detect Vocal Hyperfunction From Ambulatory Neck-Surface Acceleration Features: Initial Results For Vocal Fold Nodules". IEEE Trans Biomed Eng. 2015 Oct; 62(10):2544. PMID: 26389645.
    Citations:    Fields:    
  47. Llico AF, Zañartu M, González AJ, Wodicka GR, Mehta DD, Van Stan JH, Hillman RE. Real-time estimation of aerodynamic features for ambulatory voice biofeedback. J Acoust Soc Am. 2015 Jul; 138(1):EL14-9. PMID: 26233054.
    Citations: 10     Fields:    Translation:Humans
  48. Luegmair G, Mehta DD, Kobler JB, Döllinger M. Three-Dimensional Optical Reconstruction of Vocal Fold Kinematics Using High-Speed Video With a Laser Projection System. IEEE Trans Med Imaging. 2015 Dec; 34(12):2572-82. PMID: 26087485.
    Citations: 9     Fields:    Translation:Humans
  49. Van Stan JH, Mehta DD, Hillman RE. The Effect of Voice Ambulatory Biofeedback on the Daily Performance and Retention of a Modified Vocal Motor Behavior in Participants With Normal Voices. J Speech Lang Hear Res. 2015 Jun; 58(3):713-21. PMID: 25765862.
    Citations: 7     Fields:    Translation:Humans
  50. Van Stan JH, Mehta DD, Zeitels SM, Burns JA, Barbu AM, Hillman RE. Average Ambulatory Measures of Sound Pressure Level, Fundamental Frequency, and Vocal Dose Do Not Differ Between Adult Females With Phonotraumatic Lesions and Matched Control Subjects. Ann Otol Rhinol Laryngol. 2015 Nov; 124(11):864-74. PMID: 26024911.
    Citations: 12     Fields:    Translation:Humans
  51. Mehta DD, Wolfe PJ. Statistical properties of linear prediction analysis underlying the challenge of formant bandwidth estimation. J Acoust Soc Am. 2015 Feb; 137(2):944-50. PMID: 25698026.
    Citations: 4     Fields:    Translation:Humans
  52. Ghassemi M, Van Stan JH, Mehta DD, Zañartu M, Cheyne HA, Hillman RE, Guttag JV. Learning to detect vocal hyperfunction from ambulatory neck-surface acceleration features: initial results for vocal fold nodules. IEEE Trans Biomed Eng. 2014 Jun; 61(6):1668-75. PMID: 24845276.
    Citations: 15     Fields:    Translation:Humans
  53. Mehta DD, Rudoy D, Wolfe PJ. Erratum: Kalman-based autoregressive moving average modeling and inference for formant and antiformant tracking [J. Acoust. Soc. Am. 132(3), 1732-1746 (2012)]. J Acoust Soc Am. 2014 May; 135(5):3128. PMID: 24815287.
    Citations:    
  54. Zañartu M, Ho JC, Mehta DD, Hillman RE, Wodicka GR. Subglottal Impedance-Based Inverse Filtering of Voiced Sounds Using Neck Surface Acceleration. IEEE Trans Audio Speech Lang Process. 2013 Sep; 21(9):1929-1939. PMID: 25400531.
    Citations: 17     
  55. Mehta DD, Hillman RE. Current role of stroboscopy in laryngeal imaging. Curr Opin Otolaryngol Head Neck Surg. 2012 Dec; 20(6):429-36. PMID: 22931908.
    Citations: 19     Fields:    Translation:Humans
  56. Roy N, Barkmeier-Kraemer J, Eadie T, Sivasankar MP, Mehta D, Paul D, Hillman R. Evidence-based clinical voice assessment: a systematic review. Am J Speech Lang Pathol. 2013 May; 22(2):212-26. PMID: 23184134.
    Citations: 28     Fields:    Translation:Humans
  57. Mehta DD, Rudoy D, Wolfe PJ. Kalman-based autoregressive moving average modeling and inference for formant and antiformant tracking. J Acoust Soc Am. 2012 Sep; 132(3):1732-46. PMID: 22978900.
    Citations: 4     Fields:    Translation:Humans
  58. Mehta DD, Zañartu M, Feng SW, Cheyne HA, Hillman RE. Mobile voice health monitoring using a wearable accelerometer sensor and a smartphone platform. IEEE Trans Biomed Eng. 2012 Nov; 59(11):3090-6. PMID: 22875236.
    Citations: 30     Fields:    Translation:Humans
  59. Mehta DD, Zeitels SM, Burns JA, Friedman AD, Deliyski DD, Hillman RE. High-speed videoendoscopic analysis of relationships between cepstral-based acoustic measures and voice production mechanisms in patients undergoing phonomicrosurgery. Ann Otol Rhinol Laryngol. 2012 May; 121(5):341-7. PMID: 22724281.
    Citations: 5     Fields:    Translation:Humans
  60. Mehta DD, Zaéartu M, Quatieri TF, Deliyski DD, Hillman RE. Investigating acoustic correlates of human vocal fold vibratory phase asymmetry through modeling and laryngeal high-speed videoendoscopy. J Acoust Soc Am. 2011 Dec; 130(6):3999-4009. PMID: 22225054.
    Citations: 17     Fields:    Translation:Humans
  61. Karajanagi SS, Lopez-Guerra G, Park H, Kobler JB, Galindo M, Aanestad J, Mehta DD, Kumai Y, Giordano N, d'Almeida A, Heaton JT, Langer R, Herrera VL, Faquin W, Hillman RE, Zeitels SM. Assessment of canine vocal fold function after injection of a new biomaterial designed to treat phonatory mucosal scarring. Ann Otol Rhinol Laryngol. 2011 Mar; 120(3):175-84. PMID: 21510143.
    Citations: 9     Fields:    Translation:AnimalsCells
  62. Zañartu M, Mehta DD, Ho JC, Wodicka GR, Hillman RE. Observation and analysis of in vivo vocal fold tissue instabilities produced by nonlinear source-filter coupling: a case study. J Acoust Soc Am. 2011 Jan; 129(1):326-39. PMID: 21303014.
    Citations: 22     Fields:    Translation:Humans
  63. Döllinger M, Kobler J, Berry DA, Mehta DD, Luegmair G, Bohr C. Experiments on Analysing Voice Production: Excised (Human, Animal) and In Vivo (Animal) Approaches. Curr Bioinform. 2011; 6(3):286-304. PMID: 26581597.
    Citations: 8     
  64. Mehta DD, Deliyski DD, Hillman RE. Commentary on why laryngeal stroboscopy really works: clarifying misconceptions surrounding Talbot's law and the persistence of vision. J Speech Lang Hear Res. 2010 Oct; 53(5):1263-7. PMID: 20881095.
    Citations: 4     Fields:    Translation:HumansCells
  65. Mehta DD, Deliyski DD, Quatieri TF, Hillman RE. Automated measurement of vocal fold vibratory asymmetry from high-speed videoendoscopy recordings. J Speech Lang Hear Res. 2011 Feb; 54(1):47-54. PMID: 20699347.
    Citations: 19     Fields:    Translation:Humans
  66. Mehta DD, Deliyski DD, Zeitels SM, Quatieri TF, Hillman RE. Voice production mechanisms following phonosurgical treatment of early glottic cancer. Ann Otol Rhinol Laryngol. 2010 Jan; 119(1):1-9. PMID: 20128179.
    Citations: 18     Fields:    Translation:Humans
  67. Mehta DD, Hillman RE. Voice assessment: updates on perceptual, acoustic, aerodynamic, and endoscopic imaging methods. Curr Opin Otolaryngol Head Neck Surg. 2008 Jun; 16(3):211-5. PMID: 18475073.
    Citations: 12     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.