Harvard Catalyst Profiles

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Andreas A. Werdich, Ph.D.

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Biography
2006 - 2009
Postdoctoral Fellowship Award (NIH)
2010 - 2012
Postdoctoral Fellowship Award (AHA)
2012 - 2018
K99/R00 Career Development Award (NIH)

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R00HL112724 (WERDICH, ANDREAS AUGUSTINUS) Jul 1, 2015 - Jun 30, 2019
    NIH/NHLBI
    Molecular Mechanisms of Stretch-Induced Electrical Remodeling in the Heart
    Role: Principal Investigator
  2. K99HL112724 (WERDICH, ANDREAS AUGUSTINUS) Aug 21, 2012 - May 31, 2014
    NIH/NHLBI
    Molecular Mechanisms of Stretch-Induced Electrical Remodeling in the Heart
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Ghazizadeh Z, Kiviniemi T, Olafsson S, Plotnick D, Beerens ME, Zhang K, Gillon L, Steinbaugh MJ, Barrera V, Sui SH, Werdich AA, Kapur S, Eranti A, Gunn J, Jalkanen J, Airaksinen J, Kleber AG, Hollmén M, MacRae CA. Metastable Atrial State Underlies the Primary Genetic Substrate for MYL4 Mutation-Associated Atrial Fibrillation. Circulation. 2020 01 28; 141(4):301-312. PMID: 31735076.
    Citations:    
  2. Zhang K, Yuan G, Werdich AA, Zhao Y. Ibuprofen and diclofenac impair the cardiovascular development of zebrafish (Danio rerio) at low concentrations. Environ Pollut. 2020 Mar; 258:113613. PMID: 31838392.
    Citations:    
  3. Moshal KS, Roder K, Kabakov AY, Werdich AA, Chiang DY, Turan NN, Xie A, Kim TY, Cooper LL, Lu Y, Zhong M, Li W, Terentyev D, Choi BR, Karma A, MacRae CA, Koren G. LITAF (Lipopolysaccharide-Induced Tumor Necrosis Factor) Regulates Cardiac L-Type Calcium Channels by Modulating NEDD (Neural Precursor Cell Expressed Developmentally Downregulated Protein) 4-1 Ubiquitin Ligase. Circ Genom Precis Med. 2019 09; 12(9):407-420. PMID: 31462068.
    Citations:    
  4. Colombo S, de Sena-Tomás C, George V, Werdich AA, Kapur S, MacRae CA, Targoff KL. Nkx genes establish second heart field cardiomyocyte progenitors at the arterial pole and pattern the venous pole through Isl1 repression. Development. 2018 02 05; 145(3). PMID: 29361575.
    Citations:    Fields:    Translation:HumansAnimalsCells
  5. Nikolova-Krstevski V, Wagner S, Yu ZY, Cox CD, Cvetkovska J, Hill AP, Huttner IG, Benson V, Werdich AA, MacRae C, Feneley MP, Friedrich O, Martinac B, Fatkin D. Endocardial TRPC-6 Channels Act as Atrial Mechanosensors and Load-Dependent Modulators of Endocardial/Myocardial Cross-Talk. JACC Basic Transl Sci. 2017 Oct; 2(5):575-590. PMID: 30062171.
    Citations:    
  6. McPheeters MT, Wang YT, Werdich AA, Jenkins MW, Laurita KR. An infrared optical pacing system for screening cardiac electrophysiology in human cardiomyocytes. PLoS One. 2017; 12(8):e0183761. PMID: 28837652.
    Citations:    Fields:    Translation:HumansCells
  7. Nassal MM, Werdich AA, Wan X, Hoshi M, Deschênes I, Rosenbaum DS, Donahue JK. Phosphorylation at Connexin43 Serine-368 Is Necessary for Myocardial Conduction During Metabolic Stress. J Cardiovasc Electrophysiol. 2016 Jan; 27(1):110-9. PMID: 26459193.
    Citations:    Fields:    Translation:AnimalsCells
  8. Mosimann C, Panáková D, Werdich AA, Musso G, Burger A, Lawson KL, Carr LA, Nevis KR, Sabeh MK, Zhou Y, Davidson AJ, DiBiase A, Burns CE, Burns CG, MacRae CA, Zon LI. Chamber identity programs drive early functional partitioning of the heart. Nat Commun. 2015 Aug 26; 6:8146. PMID: 26306682.
    Citations: 15     Fields:    Translation:AnimalsCells
  9. Gu S, Wang YT, Ma P, Werdich AA, Rollins AM, Jenkins MW. Mapping conduction velocity of early embryonic hearts with a robust fitting algorithm. Biomed Opt Express. 2015 Jun 01; 6(6):2138-57. PMID: 26114034.
    Citations: 2     
  10. Roder K, Werdich AA, Li W, Liu M, Kim TY, Organ-Darling LE, Moshal KS, Hwang JM, Lu Y, Choi BR, MacRae CA, Koren G. RING finger protein RNF207, a novel regulator of cardiac excitation. J Biol Chem. 2014 Dec 05; 289(49):33730-40. PMID: 25281747.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  11. Arndt AK, Schafer S, Drenckhahn JD, Sabeh MK, Plovie ER, Caliebe A, Klopocki E, Musso G, Werdich AA, Kalwa H, Heinig M, Padera RF, Wassilew K, Bluhm J, Harnack C, Martitz J, Barton PJ, Greutmann M, Berger F, Hubner N, Siebert R, Kramer HH, Cook SA, MacRae CA, Klaassen S. Fine mapping of the 1p36 deletion syndrome identifies mutation of PRDM16 as a cause of cardiomyopathy. Am J Hum Genet. 2013 Jul 11; 93(1):67-77. PMID: 23768516.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  12. Nath AK, Roberts LD, Liu Y, Mahon SB, Kim S, Ryu JH, Werdich A, Januzzi JL, Boss GR, Rockwood GA, MacRae CA, Brenner M, Gerszten RE, Peterson RT. Chemical and metabolomic screens identify novel biomarkers and antidotes for cyanide exposure. FASEB J. 2013 May; 27(5):1928-38. PMID: 23345455.
    Citations: 13     Fields:    Translation:HumansAnimals
  13. Werdich AA, Brzezinski A, Jeyaraj D, Khaled Sabeh M, Ficker E, Wan X, McDermott BM, Macrae CA, Rosenbaum DS. The zebrafish as a novel animal model to study the molecular mechanisms of mechano-electrical feedback in the heart. Prog Biophys Mol Biol. 2012 Oct-Nov; 110(2-3):154-65. PMID: 22835662.
    Citations: 13     Fields:    Translation:HumansAnimals
  14. Feinberg AW, Alford PW, Jin H, Ripplinger CM, Werdich AA, Sheehy SP, Grosberg A, Parker KK. Controlling the contractile strength of engineered cardiac muscle by hierarchal tissue architecture. Biomaterials. 2012 Aug; 33(23):5732-41. PMID: 22594976.
    Citations: 46     Fields:    Translation:AnimalsCells
  15. Wang J, Panáková D, Kikuchi K, Holdway JE, Gemberling M, Burris JS, Singh SP, Dickson AL, Lin YF, Sabeh MK, Werdich AA, Yelon D, Macrae CA, Poss KD. The regenerative capacity of zebrafish reverses cardiac failure caused by genetic cardiomyocyte depletion. Development. 2011 Aug; 138(16):3421-30. PMID: 21752928.
    Citations: 98     Fields:    Translation:AnimalsCells
  16. Wythe JD, Jurynec MJ, Urness LD, Jones CA, Sabeh MK, Werdich AA, Sato M, Yost HJ, Grunwald DJ, Macrae CA, Li DY. Hadp1, a newly identified pleckstrin homology domain protein, is required for cardiac contractility in zebrafish. Dis Model Mech. 2011 Sep; 4(5):607-21. PMID: 21628396.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  17. Pong T, Adams WJ, Bray MA, Feinberg AW, Sheehy SP, Werdich AA, Parker KK. Hierarchical architecture influences calcium dynamics in engineered cardiac muscle. Exp Biol Med (Maywood). 2011 Mar; 236(3):366-73. PMID: 21330361.
    Citations: 17     Fields:    Translation:AnimalsCells
  18. Becker JR, Deo RC, Werdich AA, Panàkovà D, Coy S, MacRae CA. Human cardiomyopathy mutations induce myocyte hyperplasia and activate hypertrophic pathways during cardiogenesis in zebrafish. Dis Model Mech. 2011 May; 4(3):400-10. PMID: 21245263.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  19. Panáková D, Werdich AA, Macrae CA. Wnt11 patterns a myocardial electrical gradient through regulation of the L-type Ca(2+) channel. Nature. 2010 Aug 12; 466(7308):874-8. PMID: 20657579.
    Citations: 45     Fields:    Translation:AnimalsCells
  20. Kikuchi K, Holdway JE, Werdich AA, Anderson RM, Fang Y, Egnaczyk GF, Evans T, Macrae CA, Stainier DY, Poss KD. Primary contribution to zebrafish heart regeneration by gata4(+) cardiomyocytes. Nature. 2010 Mar 25; 464(7288):601-5. PMID: 20336144.
    Citations: 300     Fields:    Translation:AnimalsCells
  21. Kokel D, Bryan J, Laggner C, White R, Cheung CY, Mateus R, Healey D, Kim S, Werdich AA, Haggarty SJ, Macrae CA, Shoichet B, Peterson RT. Rapid behavior-based identification of neuroactive small molecules in the zebrafish. Nat Chem Biol. 2010 Mar; 6(3):231-237. PMID: 20081854.
    Citations: 139     Fields:    
  22. Werdich AA, Lima EA, Dzhura I, Singh MV, Li J, Anderson ME, Baudenbacher FJ. Differential effects of phospholamban and Ca2+/calmodulin-dependent kinase II on [Ca2+]i transients in cardiac myocytes at physiological stimulation frequencies. Am J Physiol Heart Circ Physiol. 2008 May; 294(5):H2352-62. PMID: 18359893.
    Citations: 7     Fields:    Translation:AnimalsCells
  23. Werdich AA, Baudenbacher F, Dzhura I, Jeyakumar LH, Kannankeril PJ, Fleischer S, LeGrone A, Milatovic D, Aschner M, Strauss AW, Anderson ME, Exil VJ. Polymorphic ventricular tachycardia and abnormal Ca2+ handling in very-long-chain acyl-CoA dehydrogenase null mice. Am J Physiol Heart Circ Physiol. 2007 May; 292(5):H2202-11. PMID: 17209005.
    Citations: 11     Fields:    Translation:AnimalsCells
  24. Ges IA, Ivanov BL, Werdich AA, Baudenbacher FJ. Differential pH measurements of metabolic cellular activity in nl culture volumes using microfabricated iridium oxide electrodes. Biosens Bioelectron. 2007 Feb 15; 22(7):1303-10. PMID: 16860556.
    Citations: 10     Fields:    Translation:AnimalsCells
  25. Ges IA, Ivanov BL, Schaffer DK, Lima EA, Werdich AA, Baudenbacher FJ. Thin-film IrOx pH microelectrode for microfluidic-based microsystems. Biosens Bioelectron. 2005 Aug 15; 21(2):248-56. PMID: 16023951.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  26. Werdich AA, Lima EA, Ivanov B, Ges I, Anderson ME, Wikswo JP, Baudenbacher FJ. A microfluidic device to confine a single cardiac myocyte in a sub-nanoliter volume on planar microelectrodes for extracellular potential recordings. Lab Chip. 2004 Aug; 4(4):357-62. PMID: 15269804.
    Citations: 22     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.