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Last Name

profileJonathan Noah Thon, Ph.D.

TitleAssistant Professor of Medicine
InstitutionBrigham and Women's Hospital
AddressBrigham and Women's Hospital
Division of Hematology/Department of Medicine, Karp 6
1 Blackfan Circle
Boston MA 02115
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R00HL114719     (THON, JONATHAN NOAH)Aug 15, 2013 - Apr 30, 2018
Examination of the Final Stages of Platelet Production
Role: Principal Investigator

K99HL114719     (THON, JONATHAN NOAH)Aug 15, 2013 - Jun 30, 2015
Examination of the Final Stages of Platelet Production
Role: Principal Investigator

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Cunin P, Penke LR, Thon JN, Monach PA, Jones T, Chang MH, Chen MM, Melki I, Lacroix S, Iwakura Y, Ware J, Gurish MF, Italiano JE, Boilard E, Nigrovic PA. Megakaryocytes compensate for Kit insufficiency in murine arthritis. J Clin Invest. 2017 May 01; 127(5):1714-1724. PMID: 28375155.
    View in: PubMed
  2. Thon JN, Karlsson S. How Scientists Can Become Entrepreneurs. Trends Biochem Sci. 2017 05; 42(5):327-329. PMID: 28385393.
    View in: PubMed
  3. Thon JN, Dykstra BJ, Beaulieu LM. Platelet bioreactor: accelerated evolution of design and manufacture. Platelets. 2017 Jul; 28(5):472-477. PMID: 28112988.
    View in: PubMed
  4. Matsuura S, Mi R, Koupenova M, Eliades A, Patterson S, Toselli P, Thon J, Italiano JE, Trackman PC, Papadantonakis N, Ravid K. Lysyl oxidase is associated with increased thrombosis and platelet reactivity. Blood. 2016 Mar 17; 127(11):1493-501. PMID: 26755713; PMCID: PMC4797025 [Available on 03/17/17].
  5. Shmukler BE, Huston NC, Thon JN, Ni CW, Kourkoulis G, Lawson ND, Paw BH, Alper SL. Homozygous knockout of the piezo1 gene in the zebrafish is not associated with anemia. Haematologica. 2015 Dec; 100(12):e483-5. PMID: 26294733; PMCID: PMC4666336.
  6. Thon JN, Medvetz DA, Karlsson SM, Italiano JE. Road blocks in making platelets for transfusion. J Thromb Haemost. 2015 Jun; 13 Suppl 1:S55-62. PMID: 26149051.
    View in: PubMed
  7. Thon JN. Nothing to lose: why early career scientists make ideal entrepreneurs. Trends Biochem Sci. 2014 Dec; 39(12):571-3. PMID: 25458606.
    View in: PubMed
  8. Bender M, Thon JN, Ehrlicher AJ, Wu S, Mazutis L, Deschmann E, Sola-Visner M, Italiano JE, Hartwig JH. Microtubule sliding drives proplatelet elongation and is dependent on cytoplasmic dynein. Blood. 2015 Jan 29; 125(5):860-8. PMID: 25411426; PMCID: PMC4311231.
  9. Feng Q, Shabrani N, Thon JN, Huo H, Thiel A, Machlus KR, Kim K, Brooks J, Li F, Luo C, Kimbrel EA, Wang J, Kim KS, Italiano J, Cho J, Lu SJ, Lanza R. Scalable generation of universal platelets from human induced pluripotent stem cells. Stem Cell Reports. 2014 Nov 11; 3(5):817-31. PMID: 25418726; PMCID: PMC4235139.
  10. Thon JN, Mazutis L, Wu S, Sylman JL, Ehrlicher A, Machlus KR, Feng Q, Lu S, Lanza R, Neeves KB, Weitz DA, Italiano JE. Platelet bioreactor-on-a-chip. Blood. 2014 Sep 18; 124(12):1857-67. PMID: 25606631; PMCID: PMC4168343.
  11. Bordoli MR, Yum J, Breitkopf SB, Thon JN, Italiano JE, Xiao J, Worby C, Wong SK, Lin G, Edenius M, Keller TL, Asara JM, Dixon JE, Yeo CY, Whitman M. A secreted tyrosine kinase acts in the extracellular environment. Cell. 2014 Aug 28; 158(5):1033-1044. PMID: 25171405; PMCID: PMC4149754.
  12. Thon JN, Mazutis L, Wu S, Sylman JL, Ehrlicher A, Machlus KR, Feng Q, Lu S, Lanza R, Neeves KB, Weitz DA, Italiano JE. Platelet bioreactor-on-a-chip. Blood. 2014 Jul 21. PMID: 25049277.
    View in: PubMed
  13. Thon JN. SDF-1 directs megakaryocyte relocation. Blood. 2014 Jul 10; 124(2):161-3. PMID: 25013161; PMCID: PMC4093676.
  14. Machlus KR, Thon JN, Italiano JE. Interpreting the developmental dance of the megakaryocyte: a review of the cellular and molecular processes mediating platelet formation. Br J Haematol. 2014 Apr; 165(2):227-36. PMID: 24499183.
    View in: PubMed
  15. Hildick-Smith GJ, Cooney JD, Garone C, Kremer LS, Haack TB, Thon JN, Miyata N, Lieber DS, Calvo SE, Akman HO, Yien YY, Huston NC, Branco DS, Shah DI, Freedman ML, Koehler CM, Italiano JE, Merkenschlager A, Beblo S, Strom TM, Meitinger T, Freisinger P, Donati MA, Prokisch H, Mootha VK, DiMauro S, Paw BH. Macrocytic anemia and mitochondriopathy resulting from a defect in sideroflexin 4. Am J Hum Genet. 2013 Nov 07; 93(5):906-14. PMID: 24119684; PMCID: PMC3824126.
  16. Thon JN, Kitterman AC, Italiano JE. Animating platelet production adds physiological context. Trends Mol Med. 2013 Oct; 19(10):583-5. PMID: 23953478; PMCID: PMC4418476.
  17. Gobbi G, Mirandola P, Carubbi C, Masselli E, Sykes SM, Ferraro F, Nouvenne A, Thon JN, Italiano JE, Vitale M. Proplatelet generation in the mouse requires PKCe-dependent RhoA inhibition. Blood. 2013 Aug 15; 122(7):1305-11. PMID: 23838351; PMCID: PMC3952532.
  18. Macaulay IC, Thon JN, Tijssen MR, Steele BM, MacDonald BT, Meade G, Burns P, Rendon A, Salunkhe V, Murphy RP, Bennett C, Watkins NA, He X, Fitzgerald DJ, Italiano JE, Maguire PB. Canonical Wnt signaling in megakaryocytes regulates proplatelet formation. Blood. 2013 Jan 03; 121(1):188-96. PMID: 23160460; PMCID: PMC3538329.
  19. N├╝rnberg ST, Rendon A, Smethurst PA, Paul DS, Voss K, Thon JN, Lloyd-Jones H, Sambrook JG, Tijssen MR, Italiano JE, Deloukas P, Gottgens B, Soranzo N, Ouwehand WH. A GWAS sequence variant for platelet volume marks an alternative DNM3 promoter in megakaryocytes near a MEIS1 binding site. Blood. 2012 Dec 06; 120(24):4859-68. PMID: 22972982; PMCID: PMC3520622.
  20. Thon JN, Peters CG, Machlus KR, Aslam R, Rowley J, Macleod H, Devine MT, Fuchs TA, Weyrich AS, Semple JW, Flaumenhaft R, Italiano JE. T granules in human platelets function in TLR9 organization and signaling. J Cell Biol. 2012 Aug 20; 198(4):561-74. PMID: 22908309; PMCID: PMC3514030.
  21. Smith EC, Thon JN, Devine MT, Lin S, Schulz VP, Guo Y, Massaro SA, Halene S, Gallagher P, Italiano JE, Krause DS. MKL1 and MKL2 play redundant and crucial roles in megakaryocyte maturation and platelet formation. Blood. 2012 Sep 13; 120(11):2317-29. PMID: 22806889; PMCID: PMC3447785.
  22. Thon JN, Italiano JE. Does size matter in platelet production? Blood. 2012 Aug 23; 120(8):1552-61. PMID: 22665937; PMCID: PMC3429301.
  23. Thon JN, Devine MT, Jurak Begonja A, Tibbitts J, Italiano JE. High-content live-cell imaging assay used to establish mechanism of trastuzumab emtansine (T-DM1)--mediated inhibition of platelet production. Blood. 2012 Sep 06; 120(10):1975-84. PMID: 22665936; PMCID: PMC3437592.
  24. Thon JN, Macleod H, Begonja AJ, Zhu J, Lee KC, Mogilner A, Hartwig JH, Italiano JE. Microtubule and cortical forces determine platelet size during vascular platelet production. Nat Commun. 2012 May 22; 3:852. PMID: 22617292.
    View in: PubMed
  25. Thon JN, Italiano JE. Visualization and manipulation of the platelet and megakaryocyte cytoskeleton. Methods Mol Biol. 2012; 788:109-25. PMID: 22130704.
    View in: PubMed
  26. Thon JN, Italiano JE. Platelets: production, morphology and ultrastructure. Handb Exp Pharmacol. 2012; (210):3-22. PMID: 22918725.
    View in: PubMed
  27. Patel-Hett S, Wang H, Begonja AJ, Thon JN, Alden EC, Wandersee NJ, An X, Mohandas N, Hartwig JH, Italiano JE. The spectrin-based membrane skeleton stabilizes mouse megakaryocyte membrane systems and is essential for proplatelet and platelet formation. Blood. 2011 Aug 11; 118(6):1641-52. PMID: 21566095; PMCID: PMC3156050.
  28. Lu SJ, Li F, Yin H, Feng Q, Kimbrel EA, Hahm E, Thon JN, Wang W, Italiano JE, Cho J, Lanza R. Platelets generated from human embryonic stem cells are functional in vitro and in the microcirculation of living mice. Cell Res. 2011 Mar; 21(3):530-45. PMID: 21221130; PMCID: PMC3193430.
  29. Thon JN, Montalvo A, Patel-Hett S, Devine MT, Richardson JL, Ehrlicher A, Larson MK, Hoffmeister K, Hartwig JH, Italiano JE. Cytoskeletal mechanics of proplatelet maturation and platelet release. J Cell Biol. 2010 Nov 15; 191(4):861-74. PMID: 21079248; PMCID: PMC2983072.
  30. Thon JN, Italiano JE. Platelet formation. Semin Hematol. 2010 Jul; 47(3):220-6. PMID: 20620432; PMCID: PMC2904625.
  31. Chase TH, Lyons BL, Bronson RT, Foreman O, Donahue LR, Burzenski LM, Gott B, Lane P, Harris B, Ceglarek U, Thiery J, Wittenburg H, Thon JN, Italiano JE, Johnson KR, Shultz LD. The mouse mutation "thrombocytopenia and cardiomyopathy" (trac) disrupts Abcg5: a spontaneous single gene model for human hereditary phytosterolemia/sitosterolemia. Blood. 2010 Feb 11; 115(6):1267-76. PMID: 19846887; PMCID: PMC2826237.
  32. Schubert P, Thon JN, Walsh GM, Chen CH, Moore ED, Devine DV, Kast J. A signaling pathway contributing to platelet storage lesion development: targeting PI3-kinase-dependent Rap1 activation slows storage-induced platelet deterioration. Transfusion. 2009 Sep; 49(9):1944-55. PMID: 19497060.
    View in: PubMed
  33. Thon JN, Schubert P, Devine DV. Platelet storage lesion: a new understanding from a proteomic perspective. Transfus Med Rev. 2008 Oct; 22(4):268-79. PMID: 18848154.
    View in: PubMed
  34. Thon JN, Schubert P, Duguay M, Serrano K, Lin S, Kast J, Devine DV. Comprehensive proteomic analysis of protein changes during platelet storage requires complementary proteomic approaches. Transfusion. 2008 Mar; 48(3):425-35. PMID: 18067510.
    View in: PubMed
  35. Thon JN, Devine DV. Translation of glycoprotein IIIa in stored blood platelets. Transfusion. 2007 Dec; 47(12):2260-70. PMID: 17714413.
    View in: PubMed
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