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Philippe Grandjean, D.M.Sc., M.D.

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Overview
Dr. Grandjean is an environmental epidemiologist whose research focuses on the long-term impacts of developmental exposure to environmental chemicals. In the mid-1980s, he initiated studies on marine contaminants in the Faroe Islands, where prospective birth cohort studies at first emphasized neurotoxicity, especially from methylmercury. More recent projects have examined general development and immunotoxicity in birth cohort subjects followed so far up to age 22 years. The results have had substantial public policy impact and inspired downward revisions of methylmercury exposure limits internationally. Other studies in the Faroes target age-related functional deficits and degenerative diseases, such as Parkinson's disease and cardiovascular disease, in regard to life-time exposure to methylmercury and persistent lipophilic contaminants. Research abroad also includes studies of pesticide neurotoxicity and endocrine disruption in children with prenatal exposures from their mother's work in greenhouses during pregnancy. Additional efforts relate to fluoride neurotoxicity; metal toxicology; biomarker development and validation; endocrine disruption caused by organochlorine substances; and carcinogenicity of exposure to zeolite and other mineral fibers. Occupational health studies have included research on percutaneous absorption of chemicals, carcinogenicity of fluoride exposure, and neurotoxicity of lead. Additional publications are on research ethics, genetic susceptibility, the setting of exposure limits, and the impact of the precautionary principle on prevention and research.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01ES030394 (GRANDJEAN, PHILIPPE ADAM) Apr 1, 2020 - Jan 31, 2024
    NIH
    Vulnerability During Infancy to Immunotoxic Contaminant Exposures
    Role: Principal Investigator
  2. U01TS000313 (SCHAIDER, LAUREL A.) Sep 30, 2019 - Sep 29, 2024
    NIH
    Assessment of PFAS exposures and health effects in two Massachusetts communities with PFAS drinking water contamination
    Role: Co-Principal Investigator
  3. R13ES029385 (GRANDJEAN, PHILIPPE ADAM) Apr 1, 2018 - Mar 31, 2019
    NIH
    Prenatal Programming and Toxicity (PPTOX) V1
    Role: Principal Investigator
  4. R01ES026596 (GRANDJEAN, PHILIPPE ADAM) Sep 15, 2017 - Aug 31, 2020
    NIH
    Inflammation and metabolic abnormalities in pollutant-exposed children
    Role: Principal Investigator
  5. R21ES023376 (GRANDJEAN, PHILIPPE ADAM) Jan 29, 2014 - Jul 31, 2020
    NIH
    Gut Microbiome in Adults with Early Life Exposures to Environmental Chemicals
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Shih YH, Blomberg AJ, Bind MA, Holm D, Nielsen F, Heilmann C, Weihe P, Grandjean P. Serum vaccine antibody concentrations in adults exposed to per- and polyfluoroalkyl substances: A birth cohort in the Faroe Islands. J Immunotoxicol. 2021 12; 18(1):85-92. PMID: 34143710.
    Citations:    Fields:    
  2. Timmermann CAG, Andersen MS, Budtz-Jørgensen E, Boye H, Nielsen F, Jensen RC, Bruun S, Husby S, Grandjean P, Jensen TK. Pregnancy exposure to perfluoroalkyl substances, prolactin concentrations and breastfeeding in the Odense Child Cohort. J Clin Endocrinol Metab. 2021 Sep 16. PMID: 34529060.
    Citations:    Fields:    
  3. Etzel RA, Grandjean P, Ozonoff DM. Environmental epidemiology in a crossfire. Environ Health. 2021 08 19; 20(1):91. PMID: 34412648.
    Citations:    Fields:    
  4. Shih YH, Blomberg AJ, Jørgensen LH, Weihe P, Grandjean P. Early-life exposure to perfluoroalkyl substances in relation to serum adipokines in a longitudinal birth cohort. Environ Res. 2021 Aug 19; 204(Pt A):111905. PMID: 34419464.
    Citations:    Fields:    
  5. Jørgensen LH, Sindahl CH, Pedersen L, Nielsen F, Jensen TK, Tolstrup J, Ekholm O, Grandjean P. Reference intervals for trace elements in the general Danish population and their dependence on serum proteins. Scand J Clin Lab Invest. 2021 Aug 08; 1-9. PMID: 34369211.
    Citations:    Fields:    
  6. Timmermann CAG, Pedersen HS, Weihe P, Bjerregaard P, Nielsen F, Heilmann C, Grandjean P. Concentrations of tetanus and diphtheria antibodies in vaccinated Greenlandic children aged 7-12 years exposed to marine pollutants, a cross sectional study. Environ Res. 2021 Jul 31; 203:111712. PMID: 34343554.
    Citations:    Fields:    
  7. Valvi D, Højlund K, Coull BA, Nielsen F, Weihe P, Grandjean P. Life-course Exposure to Perfluoroalkyl Substances in Relation to Markers of Glucose Homeostasis in Early Adulthood. J Clin Endocrinol Metab. 2021 Jul 13; 106(8):2495-2504. PMID: 33890111.
    Citations: 2     Fields:    
  8. Grandjean P, Hu H, Till C, Green R, Bashash M, Flora D, Tellez-Rojo MM, Song PXK, Lanphear B, Budtz-Jørgensen E. A Benchmark Dose Analysis for Maternal Pregnancy Urine-Fluoride and IQ in Children. Risk Anal. 2021 Jun 08. PMID: 34101876.
    Citations:    Fields:    
  9. Blomberg AJ, Shih YH, Messerlian C, Jørgensen LH, Weihe P, Grandjean P. Early-life associations between per- and polyfluoroalkyl substances and serum lipids in a longitudinal birth cohort. Environ Res. 2021 09; 200:111400. PMID: 34081971.
    Citations:    Fields:    Translation:Humans
  10. Andersen HR, Dalsager L, Jensen IK, Timmermann CAG, Olesen TS, Trecca F, Nielsen F, Schoeters G, Kyhl HB, Grandjean P, Bilenberg N, Bleses D, Jensen TK. Prenatal exposure to pyrethroid and organophosphate insecticides and language development at age 20-36 months among children in the Odense Child Cohort. Int J Hyg Environ Health. 2021 06; 235:113755. PMID: 33962121.
    Citations:    Fields:    
  11. Kupsco A, Prada D, Valvi D, Hu L, Petersen MS, Coull B, Grandjean P, Weihe P, Baccarelli AA. Human milk extracellular vesicle miRNA expression and associations with maternal characteristics in a population-based cohort from the Faroe Islands. Sci Rep. 2021 Mar 12; 11(1):5840. PMID: 33712635.
    Citations: 5     Fields:    
  12. Birukov A, Andersen LB, Andersen MS, Nielsen JH, Nielsen F, Kyhl HB, Jørgensen JS, Grandjean P, Dechend R, Jensen TK. Exposure to perfluoroalkyl substances and blood pressure in pregnancy among 1436 women from the Odense Child Cohort. Environ Int. 2021 06; 151:106442. PMID: 33610053.
    Citations: 1     Fields:    Translation:Humans
  13. Krishnankutty N, Storgaard Jensen T, Kjær J, Jørgensen JS, Nielsen F, Grandjean P. Public-health risks from tea drinking: Fluoride exposure. Scand J Public Health. 2021 Feb 08; 1403494821990284. PMID: 33557697.
    Citations: 1     Fields:    
  14. Dalsager L, Christensen N, Halekoh U, Timmermann CAG, Nielsen F, Kyhl HB, Husby S, Grandjean P, Jensen TK, Andersen HR. Exposure to perfluoroalkyl substances during fetal life and hospitalization for infectious disease in childhood: A study among 1,503 children from the Odense Child Cohort. Environ Int. 2021 04; 149:106395. PMID: 33508532.
    Citations: 2     Fields:    Translation:Humans
  15. Grandjean P, Timmermann CAG, Kruse M, Nielsen F, Vinholt PJ, Boding L, Heilmann C, Mølbak K. Severity of COVID-19 at elevated exposure to perfluorinated alkylates. PLoS One. 2020; 15(12):e0244815. PMID: 33382826.
    Citations: 5     Fields:    Translation:HumansPHPublic Health
  16. Landrigan PJ, Stegeman JJ, Fleming LE, Allemand D, Anderson DM, Backer LC, Brucker-Davis F, Chevalier N, Corra L, Czerucka D, Bottein MD, Demeneix B, Depledge M, Deheyn DD, Dorman CJ, Fénichel P, Fisher S, Gaill F, Galgani F, Gaze WH, Giuliano L, Grandjean P, Hahn ME, Hamdoun A, Hess P, Judson B, Laborde A, McGlade J, Mu J, Mustapha A, Neira M, Noble RT, Pedrotti ML, Reddy C, Rocklöv J, Scharler UM, Shanmugam H, Taghian G, van de Water JAJM, Vezzulli L, Weihe P, Zeka A, Raps H, Rampal P. Human Health and Ocean Pollution. Ann Glob Health. 2020 12 03; 86(1):151. PMID: 33354517.
    Citations: 6     Fields:    
  17. Grandjean P, Hu H, Till C, Green R, Bashash M, Flora D, Tellez-Rojo MM, Song P, Lanphear B, Budtz-Jørgensen E. A Benchmark Dose Analysis for Maternal Pregnancy Urine-Fluoride and IQ in Children. medRxiv. 2020 Nov 04. PMID: 33173917.
    Citations:    
  18. Wu Q, Coumoul X, Grandjean P, Barouki R, Audouze K. Endocrine disrupting chemicals and COVID-19 relationships: A computational systems biology approach. Environ Int. 2021 12; 157:106232. PMID: 33223326.
    Citations: 3     Fields:    
  19. Grandjean P, Timmermann CAG, Kruse M, Nielsen F, Vinholt PJ, Boding L, Heilmann C, Mølbak K. Severity of COVID-19 at elevated exposure to perfluorinated alkylates. medRxiv. 2020 Oct 26. PMID: 33140071.
    Citations:    
  20. Gardener H, Sun Q, Grandjean P. PFAS concentration during pregnancy in relation to cardiometabolic health and birth outcomes. Environ Res. 2021 01; 192:110287. PMID: 33038367.
    Citations: 2     Fields:    Translation:Humans
  21. Timmermann CAG, Jensen KJ, Nielsen F, Budtz-Jørgensen E, van der Klis F, Benn CS, Grandjean P, Fisker AB. Serum Perfluoroalkyl Substances, Vaccine Responses, and Morbidity in a Cohort of Guinea-Bissau Children. Environ Health Perspect. 2020 08; 128(8):87002. PMID: 32772733.
    Citations: 1     Fields:    Translation:HumansPHPublic Health
  22. Wu Q, Coumoul X, Grandjean P, Barouki R, Audouze K. Endocrine disrupting chemicals and COVID-19 relationships: a computational systems biology approach. medRxiv. 2020 Jul 15. PMID: 32699854.
    Citations:    
  23. Mie A, Rudén C, Grandjean P. Correction to: Response to Juberg et al. Environ Health. 2020 Jul 08; 19(1):76. PMID: 32635914.
    Citations:    Fields:    
  24. Jensen RC, Andersen MS, Larsen PV, Glintborg D, Dalgård C, Timmermann CAG, Nielsen F, Sandberg MB, Andersen HR, Christesen HT, Grandjean P, Jensen TK. Prenatal Exposures to Perfluoroalkyl Acids and Associations with Markers of Adiposity and Plasma Lipids in Infancy: An Odense Child Cohort Study. Environ Health Perspect. 2020 07; 128(7):77001. PMID: 32628516.
    Citations: 2     Fields:    Translation:HumansPHPublic Health
  25. Waterfield G, Rogers M, Grandjean P, Auffhammer M, Sunding D. Reducing exposure to high levels of perfluorinated compounds in drinking water improves reproductive outcomes: evidence from an intervention in Minnesota. Environ Health. 2020 04 22; 19(1):42. PMID: 32321520.
    Citations: 1     Fields:    Translation:HumansPHPublic Health
  26. Xiao C, Grandjean P, Valvi D, Nielsen F, Jensen TK, Weihe P, Oulhote Y. Associations of Exposure to Perfluoroalkyl Substances With Thyroid Hormone Concentrations and Birth Size. J Clin Endocrinol Metab. 2020 03 01; 105(3). PMID: 31665456.
    Citations: 7     Fields:    Translation:HumansAnimalsPHPublic Health
  27. Liu G, Zhang B, Hu Y, Rood J, Liang L, Qi L, Bray GA, DeJonge L, Coull B, Grandjean P, Furtado JD, Sun Q. Associations of Perfluoroalkyl substances with blood lipids and Apolipoproteins in lipoprotein subspecies: the POUNDS-lost study. Environ Health. 2020 01 13; 19(1):5. PMID: 31931806.
    Citations: 7     Fields: