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Philippe Grandjean, D.M.Sc., M.D.

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Overview
Dr. Grandjean is an environmental epidemiologist whose research focuses on the long-term impacts of developmental exposure to environmental chemicals. In the mid-1980s, he initiated studies on marine contaminants in the Faroe Islands, where prospective birth cohort studies at first emphasized neurotoxicity, especially from methylmercury. More recent projects have examined general development and immunotoxicity in birth cohort subjects followed so far up to age 22 years. The results have had substantial public policy impact and inspired downward revisions of methylmercury exposure limits internationally. Other studies in the Faroes target age-related functional deficits and degenerative diseases, such as Parkinson's disease and cardiovascular disease, in regard to life-time exposure to methylmercury and persistent lipophilic contaminants. Research abroad also includes studies of pesticide neurotoxicity and endocrine disruption in children with prenatal exposures from their mother's work in greenhouses during pregnancy. Additional efforts relate to fluoride neurotoxicity; metal toxicology; biomarker development and validation; endocrine disruption caused by organochlorine substances; and carcinogenicity of exposure to zeolite and other mineral fibers. Occupational health studies have included research on percutaneous absorption of chemicals, carcinogenicity of fluoride exposure, and neurotoxicity of lead. Additional publications are on research ethics, genetic susceptibility, the setting of exposure limits, and the impact of the precautionary principle on prevention and research.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01ES030394 (GRANDJEAN, PHILIPPE ADAM) Apr 1, 2020 - Jan 31, 2024
    NIH
    Vulnerability During Infancy to Immunotoxic Contaminant Exposures
    Role: Principal Investigator
  2. U01TS000313 (SCHAIDER, LAUREL A.) Sep 30, 2019 - Sep 29, 2024
    NIH
    Assessment of PFAS exposures and health effects in two Massachusetts communities with PFAS drinking water contamination
    Role: Co-Principal Investigator
  3. R13ES029385 (GRANDJEAN, PHILIPPE ADAM) Apr 1, 2018 - Mar 31, 2019
    NIH
    Prenatal Programming and Toxicity (PPTOX) V1
    Role: Principal Investigator
  4. R01ES026596 (GRANDJEAN, PHILIPPE ADAM) Sep 15, 2017 - Aug 31, 2020
    NIH
    Inflammation and metabolic abnormalities in pollutant-exposed children
    Role: Principal Investigator
  5. R21ES023376 (GRANDJEAN, PHILIPPE ADAM) Jan 29, 2014 - Jul 31, 2020
    NIH
    Gut Microbiome in Adults with Early Life Exposures to Environmental Chemicals
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Timmermann CAG, Andersen MS, Budtz-Jørgensen E, Boye H, Nielsen F, Jensen RC, Bruun S, Husby S, Grandjean P, Jensen TK. Pregnancy Exposure to Perfluoroalkyl Substances and Associations With Prolactin Concentrations and Breastfeeding in the Odense Child Cohort. J Clin Endocrinol Metab. 2022 01 18; 107(2):e631-e642. PMID: 34529060.
    Citations: 3     Fields:    Translation:HumansPHPublic Health
  2. Shih YH, Blomberg AJ, Bind MA, Holm D, Nielsen F, Heilmann C, Weihe P, Grandjean P. Serum vaccine antibody concentrations in adults exposed to per- and polyfluoroalkyl substances: A birth cohort in the Faroe Islands. J Immunotoxicol. 2021 12; 18(1):85-92. PMID: 34143710.
    Citations:    Fields:    Translation:Humans
  3. Landrigan P, Grandjean P. Pollution and the developing brain. Lancet. 2021 11 27; 398(10315):1961. PMID: 34838170.
    Citations:    Fields:    Translation:HumansPHPublic Health
  4. Kupsco A, Lee JJ, Prada D, Valvi D, Hu L, Petersen MS, Coull BA, Weihe P, Grandjean P, Baccarelli AA. Marine pollutant exposures and human milk extracellular vesicle-microRNAs in a mother-infant cohort from the Faroe Islands. Environ Int. 2022 01; 158:106986. PMID: 34991248.
    Citations:    Fields:    Translation:HumansCells
  5. Lochhead P, Khalili H, Ananthakrishnan AN, Burke KE, Richter JM, Sun Q, Grandjean P, Chan AT. Plasma concentrations of perfluoroalkyl substances and risk of inflammatory bowel diseases in women: A nested case control analysis in the Nurses' Health Study cohorts. Environ Res. 2022 05 01; 207:112222. PMID: 34662575.
    Citations: 1     Fields:    
  6. Dalsager L, Jensen TK, Nielsen F, Grandjean P, Bilenberg N, Andersen HR. No association between maternal and child PFAS concentrations and repeated measures of ADHD symptoms at age 2½ and 5 years in children from the Odense Child Cohort. Neurotoxicol Teratol. 2021 Nov-Dec; 88:107031. PMID: 34563660.
    Citations:    Fields:    Translation:HumansPHPublic Health
  7. Etzel RA, Grandjean P, Ozonoff DM. Environmental epidemiology in a crossfire. Environ Health. 2021 08 19; 20(1):91. PMID: 34412648.
    Citations:    Fields:    Translation:Humans
  8. Shih YH, Blomberg AJ, Jørgensen LH, Weihe P, Grandjean P. Early-life exposure to perfluoroalkyl substances in relation to serum adipokines in a longitudinal birth cohort. Environ Res. 2022 03; 204(Pt A):111905. PMID: 34419464.
    Citations:    Fields:    Translation:Humans
  9. Jørgensen LH, Sindahl CH, Pedersen L, Nielsen F, Jensen TK, Tolstrup J, Ekholm O, Grandjean P. Reference intervals for trace elements in the general Danish population and their dependence on serum proteins. Scand J Clin Lab Invest. 2021 Nov; 81(7):523-531. PMID: 34369211.
    Citations:    Fields:    Translation:Humans
  10. Timmermann CAG, Pedersen HS, Weihe P, Bjerregaard P, Nielsen F, Heilmann C, Grandjean P. Concentrations of tetanus and diphtheria antibodies in vaccinated Greenlandic children aged 7-12 years exposed to marine pollutants, a cross sectional study. Environ Res. 2022 01; 203:111712. PMID: 34343554.
    Citations:    Fields:    Translation:Humans
  11. Valvi D, Højlund K, Coull BA, Nielsen F, Weihe P, Grandjean P. Life-course Exposure to Perfluoroalkyl Substances in Relation to Markers of Glucose Homeostasis in Early Adulthood. J Clin Endocrinol Metab. 2021 07 13; 106(8):2495-2504. PMID: 33890111.
    Citations: 4     Fields:    Translation:HumansCellsPHPublic Health
  12. Grandjean P, Hu H, Till C, Green R, Bashash M, Flora D, Tellez-Rojo MM, Song PXK, Lanphear B, Budtz-Jørgensen E. A Benchmark Dose Analysis for Maternal Pregnancy Urine-Fluoride and IQ in Children. Risk Anal. 2021 Jun 08. PMID: 34101876.
    Citations: 2     Fields:    
  13. Blomberg AJ, Shih YH, Messerlian C, Jørgensen LH, Weihe P, Grandjean P. Early-life associations between per- and polyfluoroalkyl substances and serum lipids in a longitudinal birth cohort. Environ Res. 2021 09; 200:111400. PMID: 34081971.
    Citations: 3     Fields:    Translation:Humans
  14. Andersen HR, Dalsager L, Jensen IK, Timmermann CAG, Olesen TS, Trecca F, Nielsen F, Schoeters G, Kyhl HB, Grandjean P, Bilenberg N, Bleses D, Jensen TK. Prenatal exposure to pyrethroid and organophosphate insecticides and language development at age 20-36 months among children in the Odense Child Cohort. Int J Hyg Environ Health. 2021 06; 235:113755. PMID: 33962121.
    Citations:    Fields:    Translation:HumansPHPublic Health
  15. Kupsco A, Prada D, Valvi D, Hu L, Petersen MS, Coull B, Grandjean P, Weihe P, Baccarelli AA. Human milk extracellular vesicle miRNA expression and associations with maternal characteristics in a population-based cohort from the Faroe Islands. Sci Rep. 2021 03 12; 11(1):5840. PMID: 33712635.
    Citations: 8     Fields:    Translation:HumansCells
  16. Birukov A, Andersen LB, Andersen MS, Nielsen JH, Nielsen F, Kyhl HB, Jørgensen JS, Grandjean P, Dechend R, Jensen TK. Exposure to perfluoroalkyl substances and blood pressure in pregnancy among 1436 women from the Odense Child Cohort. Environ Int. 2021 06; 151:106442. PMID: 33610053.
    Citations: 1     Fields: