Harvard Catalyst Profiles
Contact, publication, and social network information about Harvard faculty and fellows.
Home
About
Overview
Open Source Software
Help
History (1)
Grandjean, Philippe
See All Pages
Find People
Find Everything
Login
to
edit your profile
(add a photo, education, awards, etc.), search
student opportunities
, and
create reports
.
Edit My Profile
My Person List (
0
)
Opportunity Search
Return to Top
Philippe Grandjean, D.M.Sc., M.D.
Title
Adjunct Professor of Environmental Health
Institution
Harvard T.H. Chan School of Public Health
Department
EH - Environmental + Occupational Medicine + Epi
Address
Harvard T.H. Chan School of Public Health
Bldg 1, room 1312A
665 Huntington Ave
Boston MA 02115
Phone
617/384-8907
vCard
Download vCard
(
login for email
)
overview
|
research activities and funding
|
selected publications
|
Overview
overview
Dr. Grandjean is an environmental epidemiologist whose research focuses on the long-term impacts of developmental exposure to environmental chemicals. In the mid-1980s, he initiated studies on marine contaminants in the Faroe Islands, where prospective birth cohort studies at first emphasized neurotoxicity, especially from methylmercury. More recent projects have examined general development and immunotoxicity in birth cohort subjects followed so far up to age 22 years. The results have had substantial public policy impact and inspired downward revisions of methylmercury exposure limits internationally. Other studies in the Faroes target age-related functional deficits and degenerative diseases, such as Parkinson's disease and cardiovascular disease, in regard to life-time exposure to methylmercury and persistent lipophilic contaminants. Research abroad also includes studies of pesticide neurotoxicity and endocrine disruption in children with prenatal exposures from their mother's work in greenhouses during pregnancy. Additional efforts relate to fluoride neurotoxicity; metal toxicology; biomarker development and validation; endocrine disruption caused by organochlorine substances; and carcinogenicity of exposure to zeolite and other mineral fibers. Occupational health studies have included research on percutaneous absorption of chemicals, carcinogenicity of fluoride exposure, and neurotoxicity of lead. Additional publications are on research ethics, genetic susceptibility, the setting of exposure limits, and the impact of the precautionary principle on prevention and research.
Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can
login
to make corrections and additions.
Most Recent
|
List All
R01ES030394
(GRANDJEAN, PHILIPPE ADAM)
Apr 1, 2020 - Jan 31, 2024
NIH
Vulnerability During Infancy to Immunotoxic Contaminant Exposures
Role: Principal Investigator
U01TS000313
(SCHAIDER, LAUREL A.)
Sep 30, 2019 - Sep 29, 2024
NIH
Assessment of PFAS exposures and health effects in two Massachusetts communities with PFAS drinking water contamination
Role: Co-Principal Investigator
R13ES029385
(GRANDJEAN, PHILIPPE ADAM)
Apr 1, 2018 - Mar 31, 2019
NIH
Prenatal Programming and Toxicity (PPTOX) V1
Role: Principal Investigator
R01ES026596
(GRANDJEAN, PHILIPPE ADAM)
Sep 15, 2017 - Aug 31, 2020
NIH
Inflammation and metabolic abnormalities in pollutant-exposed children
Role: Principal Investigator
R21ES023376
(GRANDJEAN, PHILIPPE ADAM)
Jan 29, 2014 - Jul 31, 2020
NIH
Gut Microbiome in Adults with Early Life Exposures to Environmental Chemicals
Role: Principal Investigator
R01ES021372
(SUN, QI)
Jun 14, 2013 - Jan 31, 2019
NIH
Pollutant-related diabetes in the Nurses' Health Study II
Role: Principal Investigator
R01ES021477
(GRANDJEAN, PHILIPPE ADAM)
Feb 1, 2013 - Oct 31, 2019
NIH
Glucose Metabolism in Adults Prenatally Exposed to Diabetogenic Pollutants
Role: Principal Investigator
R01ES021993
(GRANDJEAN, PHILIPPE ADAM)
Sep 24, 2012 - Jul 31, 2019
NIH
Immunotoxicity in Humans with Lifetime Exposure to Ocean Pullutants
Role: Principal Investigator
R01ES009797
(GRANDJEAN, PHILIPPE ADAM)
Sep 15, 2007 - May 31, 2013
NIH
Mercury-Associated Neurobehavioral Deficit in Children
Role: Principal Investigator
U13TS000065
(GRANDJEAN, PHILIPPE ADAM)
May 15, 2007 - May 14, 2008
NIH
International Conference on Developmental Toxicity and Fetal Programming
Role: Principal Investigator
R01ES013692
(GRANDJEAN, PHILIPPE ADAM)
Sep 30, 2006 - Jul 31, 2011
NIH
Health Effects of Lifetime Exposure to Food Contaminants
Role: Principal Investigator
R13ES015442
(GRANDJEAN, PHILIPPE ADAM)
Sep 30, 2006 - Aug 31, 2007
NIH
International Conference on Developmental Toxicity and Fetal Programming
Role: Principal Investigator
R01ES014460
(GRANDJEAN, PHILIPPE ADAM)
Feb 16, 2006 - Jan 31, 2013
NIH
Three-generation Human Study of Reproductive Effects of Marine Food Contaminants
Role: Principal Investigator
R01ES012199
(GRANDJEAN, PHILIPPE ADAM)
Apr 1, 2003 - Feb 28, 2017
NIH
Epidemiology of Immunotoxicant Exposure in Children
Role: Principal Investigator
R01ES011681
(GRANDJEAN, PHILIPPE ADAM)
Sep 1, 2001 - Aug 31, 2006
NIH
Effects of perinatal endocrine disrupters in children
Role: Principal Investigator
U01ES009797
(GRANDJEAN, PHILIPPE ADAM)
May 1, 2000 - Apr 30, 2006
NIH
MERCURY ASSOCIATED NEUROBEHAVIORAL DEFICIT IN CHILDREN
Role: Principal Investigator
R01ES006894
(GRANDJEAN, PHILIPPE ADAM)
Sep 1, 1996 - Aug 31, 2001
NIH
NEUROBEHAVIORAL EFFECTS OF ENVIRONMENTAL PCB EXPOSURE
Role: Principal Investigator
P42ES007381
(SHERR, DAVID H)
May 1, 1995 - Mar 31, 2017
NIH/NIEHS
Receptor-based developmental and reproductive toxicity of Superfund chemicals
Role: Co-Principal Investigator
R01ES006112
(GRANDJEAN, PHILIPPE ADAM)
Sep 30, 1992 - Aug 31, 1995
NIH
NEUROBEHAVIORAL EFFECTS OF INTRAUTERINE MERCURY EXPOSURE
Role: Principal Investigator
Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can
login
to make corrections and additions.
Newest
|
Oldest
|
Most Cited
|
Most Discussed
|
Timeline
|
Field Summary
|
Plain Text
PMC Citations
indicate the number of times the publication was cited by articles in PubMed Central, and the
Altmetric
score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.)
Fields
are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
Translation
tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
Timmermann CAG, Andersen MS, Budtz-Jørgensen E, Boye H, Nielsen F, Jensen RC, Bruun S, Husby S,
Grandjean P
, Jensen TK. Pregnancy Exposure to Perfluoroalkyl Substances and Associations With Prolactin Concentrations and Breastfeeding in the Odense Child Cohort. J Clin Endocrinol Metab. 2022 01 18; 107(2):e631-e642.
PMID:
34529060
.
Citations:
3
Fields:
End
Endocrinology
Met
Metabolism
Translation:
Humans
PH
Public Health
Shih YH,
Blomberg AJ
, Bind MA, Holm D, Nielsen F, Heilmann C, Weihe P,
Grandjean P
. Serum vaccine antibody concentrations in adults exposed to per- and polyfluoroalkyl substances: A birth cohort in the Faroe Islands. J Immunotoxicol. 2021 12; 18(1):85-92.
PMID:
34143710
.
Citations:
Fields:
All
Allergy and Immunology
Tox
Toxicology
Translation:
Humans
Landrigan P
,
Grandjean P
. Pollution and the developing brain. Lancet. 2021 11 27; 398(10315):1961.
PMID:
34838170
.
Citations:
Fields:
Med
Medicine (General)
Translation:
Humans
PH
Public Health
Kupsco A, Lee JJ, Prada D,
Valvi D
, Hu L, Petersen MS, Coull BA,
Weihe P
,
Grandjean P
, Baccarelli AA. Marine pollutant exposures and human milk extracellular vesicle-microRNAs in a mother-infant cohort from the Faroe Islands. Environ Int. 2022 01; 158:106986.
PMID:
34991248
.
Citations:
Fields:
Env
Environmental Health
Tox
Toxicology
Translation:
Humans
Cells
Lochhead P
,
Khalili H
,
Ananthakrishnan AN
,
Burke KE
,
Richter JM
, Sun Q,
Grandjean P
,
Chan AT
. Plasma concentrations of perfluoroalkyl substances and risk of inflammatory bowel diseases in women: A nested case control analysis in the Nurses' Health Study cohorts. Environ Res. 2022 05 01; 207:112222.
PMID:
34662575
.
Citations:
1
Fields:
Env
Environmental Health
Dalsager L, Jensen TK, Nielsen F,
Grandjean P
, Bilenberg N, Andersen HR. No association between maternal and child PFAS concentrations and repeated measures of ADHD symptoms at age 2½ and 5 years in children from the Odense Child Cohort. Neurotoxicol Teratol. 2021 Nov-Dec; 88:107031.
PMID:
34563660
.
Citations:
Fields:
Neu
Neurology
Tox
Toxicology
Translation:
Humans
PH
Public Health
Etzel RA,
Grandjean P
, Ozonoff DM. Environmental epidemiology in a crossfire. Environ Health. 2021 08 19; 20(1):91.
PMID:
34412648
.
Citations:
Fields:
Env
Environmental Health
Translation:
Humans
Shih YH,
Blomberg AJ
, Jørgensen LH, Weihe P,
Grandjean P
. Early-life exposure to perfluoroalkyl substances in relation to serum adipokines in a longitudinal birth cohort. Environ Res. 2022 03; 204(Pt A):111905.
PMID:
34419464
.
Citations:
Fields:
Env
Environmental Health
Translation:
Humans
Jørgensen LH, Sindahl CH, Pedersen L, Nielsen F, Jensen TK, Tolstrup J, Ekholm O,
Grandjean P
. Reference intervals for trace elements in the general Danish population and their dependence on serum proteins. Scand J Clin Lab Invest. 2021 Nov; 81(7):523-531.
PMID:
34369211
.
Citations:
Fields:
Cli
Clinical Laboratory Techniques
Translation:
Humans
Timmermann CAG, Pedersen HS, Weihe P, Bjerregaard P, Nielsen F, Heilmann C,
Grandjean P
. Concentrations of tetanus and diphtheria antibodies in vaccinated Greenlandic children aged 7-12 years exposed to marine pollutants, a cross sectional study. Environ Res. 2022 01; 203:111712.
PMID:
34343554
.
Citations:
Fields:
Env
Environmental Health
Translation:
Humans
Valvi D
, Højlund K,
Coull BA
, Nielsen F,
Weihe P
,
Grandjean P
. Life-course Exposure to Perfluoroalkyl Substances in Relation to Markers of Glucose Homeostasis in Early Adulthood. J Clin Endocrinol Metab. 2021 07 13; 106(8):2495-2504.
PMID:
33890111
.
Citations:
4
Fields:
End
Endocrinology
Met
Metabolism
Translation:
Humans
Cells
PH
Public Health
Grandjean P
, Hu H, Till C, Green R, Bashash M, Flora D, Tellez-Rojo MM, Song PXK, Lanphear B, Budtz-Jørgensen E. A Benchmark Dose Analysis for Maternal Pregnancy Urine-Fluoride and IQ in Children. Risk Anal. 2021 Jun 08.
PMID:
34101876
.
Citations:
2
Fields:
Sta
Statistics as Topic
Blomberg AJ
, Shih YH,
Messerlian C
, Jørgensen LH, Weihe P,
Grandjean P
. Early-life associations between per- and polyfluoroalkyl substances and serum lipids in a longitudinal birth cohort. Environ Res. 2021 09; 200:111400.
PMID:
34081971
.
Citations:
3
Fields:
Env
Environmental Health
Translation:
Humans
Andersen HR, Dalsager L, Jensen IK, Timmermann CAG, Olesen TS, Trecca F, Nielsen F, Schoeters G, Kyhl HB,
Grandjean P
, Bilenberg N, Bleses D, Jensen TK. Prenatal exposure to pyrethroid and organophosphate insecticides and language development at age 20-36 months among children in the Odense Child Cohort. Int J Hyg Environ Health. 2021 06; 235:113755.
PMID:
33962121
.
Citations:
Fields:
Env
Environmental Health
Pub
Public Health
Translation:
Humans
PH
Public Health
Kupsco A, Prada D,
Valvi D
, Hu L, Petersen MS, Coull B,
Grandjean P
,
Weihe P
, Baccarelli AA. Human milk extracellular vesicle miRNA expression and associations with maternal characteristics in a population-based cohort from the Faroe Islands. Sci Rep. 2021 03 12; 11(1):5840.
PMID:
33712635
.
Citations:
8
Fields:
Sci
Science
Translation:
Humans
Cells
Birukov A, Andersen LB, Andersen MS, Nielsen JH, Nielsen F, Kyhl HB, Jørgensen JS,
Grandjean P
, Dechend R, Jensen TK. Exposure to perfluoroalkyl substances and blood pressure in pregnancy among 1436 women from the Odense Child Cohort. Environ Int. 2021 06; 151:106442.
PMID:
33610053
.
Citations:
1
Fields:
Env
Environmental Health