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Xinhua Chen, Ph.D.

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Biography
2008
CCFA Research Fellowship Award
2009
Young Investigator Award for Probiotics Research
2011
Career Development Award
2014
Merck MISP Award
2017
Irving W. and Charlotte F. Rabb Award

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Džunková M, Moya A, Chen X, Kelly C, D'Auria G. Detection of mixed-strain infections by FACS and ultra-low input genome sequencing. Gut Microbes. 2018 Oct 05; 1-5. PMID: 30289342.
    View in: PubMed
  2. Pollock NR, Banz A, Chen X, Williams D, Xu H, Cuddemi CA, Cui AX, Perrotta M, Alhassan E, Riou B, Lantz A, Miller MA, Kelly CP. Comparison of C. difficile Stool Toxin Concentrations in Adults with Symptomatic Infection and Asymptomatic Carriage using an Ultrasensitive Quantitative Immunoassay. Clin Infect Dis. 2018 May 17. PMID: 29788296.
    View in: PubMed
  3. Chen X, Kelly CP. On and Off: A Dual Role for Cysteine Protease Autoprocessing of C difficile Toxin B on Cytotoxicity vs Proinflammatory Toxin Actions? Cell Mol Gastroenterol Hepatol. 2018; 5(4):654-655. PMID: 29713672.
    View in: PubMed
  4. Wang J, Ghali S, Xu C, Mussatto CC, Ortiz C, Lee EC, Tran DH, Jacobs JP, Lagishetty V, Faull KF, Moller T, Rossetti M, Chen X, Koon HW. Ceragenin CSA13 Reduces Clostridium difficile Infection in Mice by Modulating the Intestinal Microbiome and Metabolites. Gastroenterology. 2018 05; 154(6):1737-1750. PMID: 29360463.
    View in: PubMed
  5. Koon HW, Wang J, Mussatto CC, Ortiz C, Lee EC, Tran DH, Chen X, Kelly CP, Pothoulakis C. Fidaxomicin and OP-1118 Inhibit Clostridium difficile Toxin A- and B-Mediated Inflammatory Responses via Inhibition of NF-?B Activity. Antimicrob Agents Chemother. 2018 Jan; 62(1). PMID: 29038278.
    View in: PubMed
  6. Džunková M, D'Auria G, Xu H, Huang J, Duan Y, Moya A, Kelly CP, Chen X. The Monoclonal Antitoxin Antibodies (Actoxumab-Bezlotoxumab) Treatment Facilitates Normalization of the Gut Microbiota of Mice with Clostridium difficile Infection. Front Cell Infect Microbiol. 2016; 6:119. PMID: 27757389.
    View in: PubMed
  7. Koon HW, Su B, Xu C, Mussatto CC, Tran DH, Lee EC, Ortiz C, Wang J, Lee JE, Ho S, Chen X, Kelly CP, Pothoulakis C. Probiotic Saccharomyces boulardii CNCM I-745 prevents outbreak-associated Clostridium difficile-associated cecal inflammation in hamsters. Am J Physiol Gastrointest Liver Physiol. 2016 10 01; 311(4):G610-G623. PMID: 27514478.
    View in: PubMed
  8. Džunková M, Moya A, Vázquez-Castellanos JF, Artacho A, Chen X, Kelly C, D'Auria G. Active and Secretory IgA-Coated Bacterial Fractions Elucidate Dysbiosis in Clostridium difficile Infection. mSphere. 2016 May-Jun; 1(3). PMID: 27303742; PMCID: PMC4888886.
  9. Hughes M, Qazi T, Berg A, Weinberg J, Chen X, Kelly CP, Farraye FA. Host Immune Response to Clostridium difficile Infection in Inflammatory Bowel Disease Patients. Inflamm Bowel Dis. 2016 Apr; 22(4):853-61. PMID: 26954708.
    View in: PubMed
  10. Song L, Zhao M, Duffy DC, Hansen J, Shields K, Wungjiranirun M, Chen X, Xu H, Leffler DA, Sambol SP, Gerding DN, Kelly CP, Pollock NR. Development and Validation of Digital Enzyme-Linked Immunosorbent Assays for Ultrasensitive Detection and Quantification of Clostridium difficile Toxins in Stool. J Clin Microbiol. 2015 Oct; 53(10):3204-12. PMID: 26202120; PMCID: PMC4572538.
  11. Han X, Feng Y, Chen X, Gerard C, Boisvert WA. Characterization of G protein coupling mediated by the conserved D134(3.49) of DRY motif, M241(6.34), and F251(6.44) residues on human CXCR1. FEBS Open Bio. 2015; 5:182-90. PMID: 25834784; PMCID: PMC4372616.
  12. Pollock NR, Song L, Zhao M, Duffy DC, Chen X, Sambol SP, Gerding DN, Kelly CP. Differential immunodetection of toxin B from highly virulent Clostridium difficile BI/NAP-1/027. J Clin Microbiol. 2015 May; 53(5):1705-8. PMID: 25716449; PMCID: PMC4400753.
  13. Zhang Z, Chen X, Hernandez LD, Lipari P, Flattery A, Chen SC, Kramer S, Polishook JD, Racine F, Cape H, Kelly CP, Therien AG. Toxin-mediated paracellular transport of antitoxin antibodies facilitates protection against Clostridium difficile infection. Infect Immun. 2015 Jan; 83(1):405-16. PMID: 25385797; PMCID: PMC4288887.
  14. Koon HW, Ho S, Hing TC, Cheng M, Chen X, Ichikawa Y, Kelly CP, Pothoulakis C. Fidaxomicin inhibits Clostridium difficile toxin A-mediated enteritis in the mouse ileum. Antimicrob Agents Chemother. 2014 Aug; 58(8):4642-50. PMID: 24890583; PMCID: PMC4135997.
  15. Yang Z, Schmidt D, Liu W, Li S, Shi L, Sheng J, Chen K, Yu H, Tremblay JM, Chen X, Piepenbrink KH, Sundberg EJ, Kelly CP, Bai G, Shoemaker CB, Feng H. A novel multivalent, single-domain antibody targeting TcdA and TcdB prevents fulminant Clostridium difficile infection in mice. J Infect Dis. 2014 Sep 15; 210(6):964-72. PMID: 24683195; PMCID: PMC4192054.
  16. Chen X, Dong M and Sun X. Mechanisms of action and applications of probiotics for the treatment of Clostridium difficile infection. Microbial pathogens and strategies for combating them: science, technology and education. 2013; 2(13):1154-1163 .
  17. Locher HH, Seiler P, Chen X, Schroeder S, Pfaff P, Enderlin M, Klenk A, Fournier E, Hubschwerlen C, Ritz D, Kelly CP, Keck W. In vitro and in vivo antibacterial evaluation of cadazolid, a new antibiotic for treatment of Clostridium difficile infections. Antimicrob Agents Chemother. 2014; 58(2):892-900. PMID: 24277020; PMCID: PMC3910819.
  18. Chen X, Lamont JT. Overview of Clostridium difficile infection: implications for China. Gastroenterol Rep (Oxf). 2013 Nov; 1(3):153-8. PMID: 24759960; PMCID: PMC3937999.
  19. Solomon K, Martin AJ, O'Donoghue C, Chen X, Fenelon L, Fanning S, Kelly CP, Kyne L. Mortality in patients with Clostridium difficile infection correlates with host pro-inflammatory and humoral immune responses. J Med Microbiol. 2013 Sep; 62(Pt 9):1453-60. PMID: 23722431.
    View in: PubMed
  20. Chen X, Yang G, Song JH, Xu H, Li D, Goldsmith J, Zeng H, Parsons-Wingerter PA, Reinecker HC, Kelly CP. Probiotic yeast inhibits VEGFR signaling and angiogenesis in intestinal inflammation. PLoS One. 2013; 8(5):e64227. PMID: 23675530; PMCID: PMC3652827.
  21. Koon HW, Shih DQ, Hing TC, Yoo JH, Ho S, Chen X, Kelly CP, Targan SR, Pothoulakis C. Human monoclonal antibodies against Clostridium difficile toxins A and B inhibit inflammatory and histologic responses to the toxins in human colon and peripheral blood monocytes. Antimicrob Agents Chemother. 2013 Jul; 57(7):3214-23. PMID: 23629713; PMCID: PMC3697353.
  22. Ghose C, Verhagen JM, Chen X, Yu J, Huang Y, Chenesseau O, Kelly CP, Ho DD. Toll-like receptor 5-dependent immunogenicity and protective efficacy of a recombinant fusion protein vaccine containing the nontoxic domains of Clostridium difficile toxins A and B and Salmonella enterica serovar typhimurium flagellin in a mouse model of Clostridium difficile disease. Infect Immun. 2013 Jun; 81(6):2190-6. PMID: 23545305; PMCID: PMC3676027.
  23. Nagel JM, Geiger BM, Karagiannis AK, Gras-Miralles B, Horst D, Najarian RM, Ziogas DC, Chen X, Kokkotou E. Reduced intestinal tumorigenesis in APCmin mice lacking melanin-concentrating hormone. PLoS One. 2012; 7(7):e41914. PMID: 22848656; PMCID: PMC3407051.
  24. Hing TC, Ho S, Shih DQ, Ichikawa R, Cheng M, Chen J, Chen X, Law I, Najarian R, Kelly CP, Gallo RL, Targan SR, Pothoulakis C, Koon HW. The antimicrobial peptide cathelicidin modulates Clostridium difficile-associated colitis and toxin A-mediated enteritis in mice. Gut. 2013 Sep; 62(9):1295-305. PMID: 22760006.
    View in: PubMed
  25. Chen X, Fruehauf J, Goldsmith JD, Xu H, Katchar KK, Koon HW, Zhao D, Kokkotou EG, Pothoulakis C, Kelly CP. Saccharomyces boulardii inhibits EGF receptor signaling and intestinal tumor growth in Apc(min) mice. Gastroenterology. 2009 Sep; 137(3):914-23. PMID: 19482027; PMCID: PMC2777664.
  26. Chen X, Katchar K, Goldsmith JD, Nanthakumar N, Cheknis A, Gerding DN, Kelly CP. A mouse model of Clostridium difficile-associated disease. Gastroenterology. 2008 Dec; 135(6):1984-92. PMID: 18848941.
    View in: PubMed
  27. Chen X, Kelly CP. Saccharomyces spp. Therapeutic Microbiology: Probiotics and Related Strategies. J. Versalovic and M. Wilson (ed.). 2008; 51-60.
  28. Mumy KL, Chen X, Kelly CP, McCormick BA. Saccharomyces boulardii interferes with Shigella pathogenesis by postinvasion signaling events. Am J Physiol Gastrointest Liver Physiol. 2008 Mar; 294(3):G599-609. PMID: 18032477; PMCID: PMC3212754.
  29. Katchar K, Taylor CP, Tummala S, Chen X, Sheikh J, Kelly CP. Association between IgG2 and IgG3 subclass responses to toxin A and recurrent Clostridium difficile-associated disease. Clin Gastroenterol Hepatol. 2007 Jun; 5(6):707-13. PMID: 17544998.
    View in: PubMed
  30. Chen X, Kokkotou EG, Mustafa N, Bhaskar KR, Sougioultzis S, O'Brien M, Pothoulakis C, Kelly CP. Saccharomyces boulardii inhibits ERK1/2 mitogen-activated protein kinase activation both in vitro and in vivo and protects against Clostridium difficile toxin A-induced enteritis. J Biol Chem. 2006 Aug 25; 281(34):24449-54. PMID: 16816386.
    View in: PubMed
  31. Sougioultzis S, Simeonidis S, Bhaskar KR, Chen X, Anton PM, Keates S, Pothoulakis C, Kelly CP. Saccharomyces boulardii produces a soluble anti-inflammatory factor that inhibits NF-kappaB-mediated IL-8 gene expression. Biochem Biophys Res Commun. 2006 Apr 28; 343(1):69-76. PMID: 16529714.
    View in: PubMed
  32. Rentsendorj A, Agadjanian H, Chen X, Cirivello M, Macveigh M, Kedes L, Hamm-Alvarez S, Medina-Kauwe LK. The Ad5 fiber mediates nonviral gene transfer in the absence of the whole virus, utilizing a novel cell entry pathway. Gene Ther. 2005 Feb; 12(3):225-37. PMID: 15483666.
    View in: PubMed
  33. Medina-Kauwe LK, Chen X. Using GFP--ligand fusions to measure receptor-mediated endocytosis in living cells. Vitam Horm. 2002; 65:81-95. PMID: 12481543.
    View in: PubMed
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.