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Xinhua Chen, Ph.D.

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Biography
2008
CCFA Research Fellowship Award
2009
Young Investigator Award for Probiotics Research
2011
Career Development Award
2014
Merck MISP Award
2017
Irving W. and Charlotte F. Rabb Award

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Kociolek LK, Espinosa RO, Gerding DN, Hauser AR, Ozer EA, Budz M, Balaji A, Chen X, Tanz RR, Yalcinkaya N, Conner ME, Savidge T, Kelly CP. Natural Clostridioides difficile toxin immunization in colonized infants. Clin Infect Dis. 2019 Jun 29. PMID: 31253983.
    Citations:    
  2. Kelly CP, Chen X, Williams D, Xu H, Cuddemi CA, Daugherty K, Barrett C, Miller M, Foussadier A, Lantz A, Banz A, Pollock NR. Host Immune Markers Distinguish Clostridioides difficile Infection From Asymptomatic Carriage and Non-C. difficile Diarrhea. Clin Infect Dis. 2019 Apr 26. PMID: 31211839.
    Citations:    
  3. Singh P, Silvester J, Chen X, Xu H, Sawhney V, Rangan V, Iturrino J, Nee J, Duerksen DR, Lembo A. Serum zonulin is elevated in IBS and correlates with stool frequency in IBS-D. United European Gastroenterol J. 2019 Jun; 7(5):709-715. PMID: 31210949.
    Citations:    
  4. Pollock NR, Banz A, Chen X, Williams D, Xu H, Cuddemi CA, Cui AX, Perrotta M, Alhassan E, Riou B, Lantz A, Miller MA, Kelly CP. Comparison of Clostridioides difficile Stool Toxin Concentrations in Adults With Symptomatic Infection and Asymptomatic Carriage Using an Ultrasensitive Quantitative Immunoassay. Clin Infect Dis. 2019 Jan 01; 68(1):78-86. PMID: 29788296.
    Citations: 1     Fields:    
  5. Huang J, Kelly CP, Bakirtzi K, Villafuerte Gálvez JA, Lyras D, Mileto SJ, Larcombe S, Xu H, Yang X, Shields KS, Zhu W, Zhang Y, Goldsmith JD, Patel IJ, Hansen J, Huang M, Yla-Herttuala S, Moss AC, Paredes-Sabja D, Pothoulakis C, Shah YM, Wang J, Chen X. Clostridium difficile toxins induce VEGF-A and vascular permeability to promote disease pathogenesis. Nat Microbiol. 2019 02; 4(2):269-279. PMID: 30510170.
    Citations:    Fields:    
  6. Džunková M, Moya A, Chen X, Kelly C, D'Auria G. Detection of mixed-strain infections by FACS and ultra-low input genome sequencing. Gut Microbes. 2018 Oct 05; 1-5. PMID: 30289342.
    Citations:    Fields:    
  7. Chen X, Kelly CP. On and Off: A Dual Role for Cysteine Protease Autoprocessing of C difficile Toxin B on Cytotoxicity vs Proinflammatory Toxin Actions? Cell Mol Gastroenterol Hepatol. 2018; 5(4):654-655. PMID: 29713672.
    Citations:    
  8. Wang J, Ghali S, Xu C, Mussatto CC, Ortiz C, Lee EC, Tran DH, Jacobs JP, Lagishetty V, Faull KF, Moller T, Rossetti M, Chen X, Koon HW. Ceragenin CSA13 Reduces Clostridium difficile Infection in Mice by Modulating the Intestinal Microbiome and Metabolites. Gastroenterology. 2018 05; 154(6):1737-1750. PMID: 29360463.
    Citations:    Fields:    Translation:AnimalsCells
  9. Koon HW, Wang J, Mussatto CC, Ortiz C, Lee EC, Tran DH, Chen X, Kelly CP, Pothoulakis C. Fidaxomicin and OP-1118 Inhibit Clostridium difficile Toxin A- and B-Mediated Inflammatory Responses via Inhibition of NF-?B Activity. Antimicrob Agents Chemother. 2018 01; 62(1). PMID: 29038278.
    Citations: 1     Fields:    
  10. Džunková M, D'Auria G, Xu H, Huang J, Duan Y, Moya A, Kelly CP, Chen X. The Monoclonal Antitoxin Antibodies (Actoxumab-Bezlotoxumab) Treatment Facilitates Normalization of the Gut Microbiota of Mice with Clostridium difficile Infection. Front Cell Infect Microbiol. 2016; 6:119. PMID: 27757389.
    Citations: 3     Fields:    Translation:AnimalsCells
  11. Koon HW, Su B, Xu C, Mussatto CC, Tran DH, Lee EC, Ortiz C, Wang J, Lee JE, Ho S, Chen X, Kelly CP, Pothoulakis C. Probiotic Saccharomyces boulardii CNCM I-745 prevents outbreak-associated Clostridium difficile-associated cecal inflammation in hamsters. Am J Physiol Gastrointest Liver Physiol. 2016 10 01; 311(4):G610-G623. PMID: 27514478.
    Citations: 3     Fields:    Translation:AnimalsCells
  12. Džunková M, Moya A, Vázquez-Castellanos JF, Artacho A, Chen X, Kelly C, D'Auria G. Active and Secretory IgA-Coated Bacterial Fractions Elucidate Dysbiosis in Clostridium difficile Infection. mSphere. 2016 May-Jun; 1(3). PMID: 27303742.
    Citations: 2     
  13. Hughes M, Qazi T, Berg A, Weinberg J, Chen X, Kelly CP, Farraye FA. Host Immune Response to Clostridium difficile Infection in Inflammatory Bowel Disease Patients. Inflamm Bowel Dis. 2016 Apr; 22(4):853-61. PMID: 26954708.
    Citations: 2     Fields:    Translation:HumansCells
  14. Song L, Zhao M, Duffy DC, Hansen J, Shields K, Wungjiranirun M, Chen X, Xu H, Leffler DA, Sambol SP, Gerding DN, Kelly CP, Pollock NR. Development and Validation of Digital Enzyme-Linked Immunosorbent Assays for Ultrasensitive Detection and Quantification of Clostridium difficile Toxins in Stool. J Clin Microbiol. 2015 Oct; 53(10):3204-12. PMID: 26202120.
    Citations: 9     Fields:    Translation:Humans
  15. Han X, Feng Y, Chen X, Gerard C, Boisvert WA. Characterization of G protein coupling mediated by the conserved D134(3.49) of DRY motif, M241(6.34), and F251(6.44) residues on human CXCR1. FEBS Open Bio. 2015; 5:182-90. PMID: 25834784.
    Citations: 2     
  16. Pollock NR, Song L, Zhao M, Duffy DC, Chen X, Sambol SP, Gerding DN, Kelly CP. Differential immunodetection of toxin B from highly virulent Clostridium difficile BI/NAP-1/027. J Clin Microbiol. 2015 May; 53(5):1705-8. PMID: 25716449.
    Citations: 4     Fields:    Translation:HumansCells
  17. Zhang Z, Chen X, Hernandez LD, Lipari P, Flattery A, Chen SC, Kramer S, Polishook JD, Racine F, Cape H, Kelly CP, Therien AG. Toxin-mediated paracellular transport of antitoxin antibodies facilitates protection against Clostridium difficile infection. Infect Immun. 2015 Jan; 83(1):405-16. PMID: 25385797.
    Citations: 9     Fields:    Translation:AnimalsCells
  18. Koon HW, Ho S, Hing TC, Cheng M, Chen X, Ichikawa Y, Kelly CP, Pothoulakis C. Fidaxomicin inhibits Clostridium difficile toxin A-mediated enteritis in the mouse ileum. Antimicrob Agents Chemother. 2014 Aug; 58(8):4642-50. PMID: 24890583.
    Citations: 7     Fields:    Translation:AnimalsCells
  19. Yang Z, Schmidt D, Liu W, Li S, Shi L, Sheng J, Chen K, Yu H, Tremblay JM, Chen X, Piepenbrink KH, Sundberg EJ, Kelly CP, Bai G, Shoemaker CB, Feng H. A novel multivalent, single-domain antibody targeting TcdA and TcdB prevents fulminant Clostridium difficile infection in mice. J Infect Dis. 2014 Sep 15; 210(6):964-72. PMID: 24683195.
    Citations: 23     Fields:    Translation:AnimalsCells
  20. Chen X, Dong M and Sun X. Mechanisms of action and applications of probiotics for the treatment of Clostridium difficile infection. Microbial pathogens and strategies for combating them: science, technology and education. 2013; 2(13):1154-1163 . View Publication.
  21. Locher HH, Seiler P, Chen X, Schroeder S, Pfaff P, Enderlin M, Klenk A, Fournier E, Hubschwerlen C, Ritz D, Kelly CP, Keck W. In vitro and in vivo antibacterial evaluation of cadazolid, a new antibiotic for treatment of Clostridium difficile infections. Antimicrob Agents Chemother. 2014; 58(2):892-900. PMID: 24277020.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  22. Chen X, Lamont JT. Overview of Clostridium difficile infection: implications for China. Gastroenterol Rep (Oxf). 2013 Nov; 1(3):153-8. PMID: 24759960.
    Citations: 3     
  23. Solomon K, Martin AJ, O'Donoghue C, Chen X, Fenelon L, Fanning S, Kelly CP, Kyne L. Mortality in patients with Clostridium difficile infection correlates with host pro-inflammatory and humoral immune responses. J Med Microbiol. 2013 Sep; 62(Pt 9):1453-60. PMID: 23722431.
    Citations: 12     Fields:    Translation:HumansCells
  24. Chen X, Yang G, Song JH, Xu H, Li D, Goldsmith J, Zeng H, Parsons-Wingerter PA, Reinecker HC, Kelly CP. Probiotic yeast inhibits VEGFR signaling and angiogenesis in intestinal inflammation. PLoS One. 2013; 8(5):e64227. PMID: 23675530.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  25. Koon HW, Shih DQ, Hing TC, Yoo JH, Ho S, Chen X, Kelly CP, Targan SR, Pothoulakis C. Human monoclonal antibodies against Clostridium difficile toxins A and B inhibit inflammatory and histologic responses to the toxins in human colon and peripheral blood monocytes. Antimicrob Agents Chemother. 2013 Jul; 57(7):3214-23. PMID: 23629713.
    Citations: 13     Fields:    Translation:HumansCells
  26. Ghose C, Verhagen JM, Chen X, Yu J, Huang Y, Chenesseau O, Kelly CP, Ho DD. Toll-like receptor 5-dependent immunogenicity and protective efficacy of a recombinant fusion protein vaccine containing the nontoxic domains of Clostridium difficile toxins A and B and Salmonella enterica serovar typhimurium flagellin in a mouse model of Clostridium difficile disease. Infect Immun. 2013 Jun; 81(6):2190-6. PMID: 23545305.
    Citations: 13     Fields:    Translation:AnimalsCells
  27. Nagel JM, Geiger BM, Karagiannis AK, Gras-Miralles B, Horst D, Najarian RM, Ziogas DC, Chen X, Kokkotou E. Reduced intestinal tumorigenesis in APCmin mice lacking melanin-concentrating hormone. PLoS One. 2012; 7(7):e41914. PMID: 22848656.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  28. Hing TC, Ho S, Shih DQ, Ichikawa R, Cheng M, Chen J, Chen X, Law I, Najarian R, Kelly CP, Gallo RL, Targan SR, Pothoulakis C, Koon HW. The antimicrobial peptide cathelicidin modulates Clostridium difficile-associated colitis and toxin A-mediated enteritis in mice. Gut. 2013 Sep; 62(9):1295-305. PMID: 22760006.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  29. Chen X, Fruehauf J, Goldsmith JD, Xu H, Katchar KK, Koon HW, Zhao D, Kokkotou EG, Pothoulakis C, Kelly CP. Saccharomyces boulardii inhibits EGF receptor signaling and intestinal tumor growth in Apc(min) mice. Gastroenterology. 2009 Sep; 137(3):914-23. PMID: 19482027.
    Citations: 14     Fields:    Translation:AnimalsCells
  30. Chen X, Katchar K, Goldsmith JD, Nanthakumar N, Cheknis A, Gerding DN, Kelly CP. A mouse model of Clostridium difficile-associated disease. Gastroenterology. 2008 Dec; 135(6):1984-92. PMID: 18848941.
    Citations: 149     Fields:    Translation:AnimalsCells
  31. Chen X, Kelly CP. Saccharomyces spp. Therapeutic Microbiology: Probiotics and Related Strategies. J. Versalovic and M. Wilson (ed.). 2008; 51-60. View Publication.
  32. Mumy KL, Chen X, Kelly CP, McCormick BA. Saccharomyces boulardii interferes with Shigella pathogenesis by postinvasion signaling events. Am J Physiol Gastrointest Liver Physiol. 2008 Mar; 294(3):G599-609. PMID: 18032477.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  33. Katchar K, Taylor CP, Tummala S, Chen X, Sheikh J, Kelly CP. Association between IgG2 and IgG3 subclass responses to toxin A and recurrent Clostridium difficile-associated disease. Clin Gastroenterol Hepatol. 2007 Jun; 5(6):707-13. PMID: 17544998.
    Citations: 15     Fields:    Translation:Humans
  34. Chen X, Kokkotou EG, Mustafa N, Bhaskar KR, Sougioultzis S, O'Brien M, Pothoulakis C, Kelly CP. Saccharomyces boulardii inhibits ERK1/2 mitogen-activated protein kinase activation both in vitro and in vivo and protects against Clostridium difficile toxin A-induced enteritis. J Biol Chem. 2006 Aug 25; 281(34):24449-54. PMID: 16816386.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  35. Sougioultzis S, Simeonidis S, Bhaskar KR, Chen X, Anton PM, Keates S, Pothoulakis C, Kelly CP. Saccharomyces boulardii produces a soluble anti-inflammatory factor that inhibits NF-kappaB-mediated IL-8 gene expression. Biochem Biophys Res Commun. 2006 Apr 28; 343(1):69-76. PMID: 16529714.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  36. Rentsendorj A, Agadjanian H, Chen X, Cirivello M, Macveigh M, Kedes L, Hamm-Alvarez S, Medina-Kauwe LK. The Ad5 fiber mediates nonviral gene transfer in the absence of the whole virus, utilizing a novel cell entry pathway. Gene Ther. 2005 Feb; 12(3):225-37. PMID: 15483666.
    Citations: 5     Fields:    Translation:HumansCells
  37. Medina-Kauwe LK, Chen X. Using GFP--ligand fusions to measure receptor-mediated endocytosis in living cells. Vitam Horm. 2002; 65:81-95. PMID: 12481543.
    Citations: 6     Fields:    Translation:HumansAnimals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.