Harvard Catalyst Profiles

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Dmitry Gerashchenko, Ph.D.

Other Positions

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AG061774 (GERASHCHENKO, DMITRY) Apr 15, 2019 - Jan 31, 2024
    Slow-wave activity as a modifier of the progression of neurodegeneration in Alzheimer's disease
    Role: Principal Investigator
  2. R21NS106406 (GERASHCHENKO, DMITRY) Aug 15, 2018 - Jul 31, 2020
    Novel molecular genetic tool for large-scale labeling and modulating activity of neurons associated with particular physiological processes and behaviors
    Role: Principal Investigator
  3. R43OD023231 (GERASHCHENKO, LUDMILA) Aug 12, 2017 - Aug 11, 2018
    System for providing an interface for interacting with an animal
    Role: Principal Investigator
  4. R43AG056250 (GARTENBERG, DANIEL) May 1, 2017 - Apr 30, 2019
    Non-pharmacological improvement of sleep structure in older people
    Role: Co-Principal Investigator
  5. R21NS092926 (GERASHCHENKO, DMITRY) Sep 1, 2015 - Aug 31, 2017
    Role of nNOS cortical neurons in slow wave activity production and cognition
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Algamal M, Russ AN, Miller MR, Hou SS, Maci M, Munting LP, Zhao Q, Gerashchenko D, Bacskai BJ, Kastanenka KV. Reduced excitatory neuron activity and interneuron-type-specific deficits in a mouse model of Alzheimer's disease. Commun Biol. 2022 12 02; 5(1):1323. PMID: 36460716; PMCID: PMC9718858.
    Citations:    Translation:AnimalsCells
  2. Thankachan S, Gerashchenko A, Kastanenka KV, Bacskai BJ, Gerashchenko D. Optimization of real-time analysis of sleep-wake cycle in mice. MethodsX. 2022; 9:101811. PMID: 36065218; PMCID: PMC9440422.
  3. Thankachan S, Yang C, Kastanenka KV, Bacskai BJ, Gerashchenko D. Low frequency visual stimulation enhances slow wave activity without disrupting the sleep pattern in mice. Sci Rep. 2022 07 19; 12(1):12278. PMID: 35853986; PMCID: PMC9296645.
    Citations:    Fields:    Translation:Animals
  4. Katsuki F, Gerashchenko D, Brown RE. Alterations of sleep oscillations in Alzheimer's disease: A potential role for GABAergic neurons in the cortex, hippocampus, and thalamus. Brain Res Bull. 2022 09; 187:181-198. PMID: 35850189; PMCID: PMC9563641.
    Citations:    Fields:    
  5. Leopold AV, Thankachan S, Yang C, Gerashchenko D, Verkhusha VV. A general approach for engineering RTKs optically controlled with far-red light. Nat Methods. 2022 07; 19(7):871-880. PMID: 35681062.
    Citations:    Fields:    Translation:AnimalsCells
  6. Lee YF, Gerashchenko D, Timofeev I, Bacskai BJ, Kastanenka KV. Slow Wave Sleep Is a Promising Intervention Target for Alzheimer's Disease. Front Neurosci. 2020; 14:705. PMID: 32714142.
    Citations: 10     
  7. Zielinski MR, Atochin DN, McNally JM, McKenna JT, Huang PL, Strecker RE, Gerashchenko D. Somatostatin+/nNOS+ neurons are involved in delta electroencephalogram activity and cortical-dependent recognition memory. Sleep. 2019 10 09; 42(10). PMID: 31328777.
    Citations: 5     Fields:    Translation:AnimalsCells
  8. Gerashchenko D, Schmidt MA, Zielinski MR, Moore ME, Wisor JP. Sleep State Dependence of Optogenetically evoked Responses in Neuronal Nitric Oxide Synthase-positive Cells of the Cerebral Cortex. Neuroscience. 2018 05 21; 379:189-201. PMID: 29438803; PMCID: PMC6311348.
    Citations: 5     Fields:    Translation:AnimalsCells
  9. Zielinski MR, Gerashchenko D. Sleep-inducing effect of substance P-cholera toxin A subunit in mice. Neurosci Lett. 2017 10 17; 659:44-47. PMID: 28866052; PMCID: PMC5624846.
    Citations: 2     Fields:    Translation:Animals
  10. Gerashchenko D, Pasumarthi RK, Kilduff TS. Plasticity-Related Gene Expression During Eszopiclone-Induced Sleep. Sleep. 2017 07 01; 40(7). PMID: 28605546.
    Citations: 2     Fields:    Translation:Animals
  11. Zielinski MR, Gerashchenko D, Karpova SA, Konanki V, McCarley RW, Sutterwala FS, Strecker RE, Basheer R. The NLRP3 inflammasome modulates sleep and NREM sleep delta power induced by spontaneous wakefulness, sleep deprivation and lipopolysaccharide. Brain Behav Immun. 2017 May; 62:137-150. PMID: 28109896.
    Citations: 16     Fields:    Translation:AnimalsCells
  12. Zielinski MR, Kim Y, Karpova SA, McCarley RW, Strecker RE, Gerashchenko D. Chronic sleep restriction elevates brain interleukin-1 beta and tumor necrosis factor-alpha and attenuates brain-derived neurotrophic factor expression. Neurosci Lett. 2014 Sep 19; 580:27-31. PMID: 25093703.
    Citations: 42     Fields:    Translation:Animals
  13. Morairty SR, Dittrich L, Pasumarthi RK, Valladao D, Heiss JE, Gerashchenko D, Kilduff TS. A role for cortical nNOS/NK1 neurons in coupling homeostatic sleep drive to EEG slow wave activity. Proc Natl Acad Sci U S A. 2013 Dec 10; 110(50):20272-7. PMID: 24191004.
    Citations: 52     Fields:    Translation:AnimalsCells
  14. Zielinski MR, Gerashchenko L, Karpova SA, Gerashchenko D. A novel telemetric system to measure polysomnographic biopotentials in freely moving animals. J Neurosci Methods. 2013 Jun 15; 216(2):79-86. PMID: 23563323.
    Citations: 7     Fields:    Translation:Animals
  15. Liu M, Blanco-Centurion C, Konadhode R, Begum S, Pelluru D, Gerashchenko D, Sakurai T, Yanagisawa M, van den Pol AN, Shiromani PJ. Orexin gene transfer into zona incerta neurons suppresses muscle paralysis in narcoleptic mice. J Neurosci. 2011 Apr 20; 31(16):6028-40. PMID: 21508228.
    Citations: 35     Fields:    Translation:AnimalsCells
  16. Wisor JP, Gerashchenko D, Kilduff TS. Sleep-active neuronal nitric oxide synthase-positive cells of the cerebral cortex: a local regulator of sleep? Curr Top Med Chem. 2011; 11(19):2483-9. PMID: 21906016.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  17. Gerashchenko D, Wisor JP, Kilduff TS. Sleep-active cells in the cerebral cortex and their role in slow-wave activity. Sleep Biol Rhythms. 2011 Jan; 9(s1):71-77. PMID: 21625335.
    Citations: 3     
  18. Gerashchenko D, Horvath TL, Xie XS. Direct inhibition of hypocretin/orexin neurons in the lateral hypothalamus by nociceptin/orphanin FQ blocks stress-induced analgesia in rats. Neuropharmacology. 2011 Mar; 60(4):543-9. PMID: 21195099.
    Citations: 15     Fields:    Translation:AnimalsCells
  19. Kilduff TS, Cauli B, Gerashchenko D. Activation of cortical interneurons during sleep: an anatomical link to homeostatic sleep regulation? Trends Neurosci. 2011 Jan; 34(1):10-9. PMID: 21030095.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  20. Thompson CL, Wisor JP, Lee CK, Pathak SD, Gerashchenko D, Smith KA, Fischer SR, Kuan CL, Sunkin SM, Ng LL, Lau C, Hawrylycz M, Jones AR, Kilduff TS, Lein ES. Molecular and anatomical signatures of sleep deprivation in the mouse brain. Front Neurosci. 2010; 4:165. PMID: 21088695.
    Citations: 42     
  21. Hara J, Gerashchenko D, Wisor JP, Sakurai T, Xie X, Kilduff TS. Thyrotropin-releasing hormone increases behavioral arousal through modulation of hypocretin/orexin neurons. J Neurosci. 2009 Mar 25; 29(12):3705-14. PMID: 19321767.
    Citations: 27     Fields:    Translation:AnimalsCells
  22. Gerashchenko D, Wisor JP, Burns D, Reh RK, Shiromani PJ, Sakurai T, de la Iglesia HO, Kilduff TS. Identification of a population of sleep-active cerebral cortex neurons. Proc Natl Acad Sci U S A. 2008 Jul 22; 105(29):10227-32. PMID: 18645184.
    Citations: 86     Fields:    Translation:AnimalsCells
  23. Wisor JP, Pasumarthi RK, Gerashchenko D, Thompson CL, Pathak S, Sancar A, Franken P, Lein ES, Kilduff TS. Sleep deprivation effects on circadian clock gene expression in the cerebral cortex parallel electroencephalographic differences among mouse strains. J Neurosci. 2008 Jul 09; 28(28):7193-201. PMID: 18614689.
    Citations: 56     Fields:    Translation:Animals
  24. Terao A, Huang ZL, Wisor JP, Mochizuki T, Gerashchenko D, Urade Y, Kilduff TS. Gene expression in the rat brain during prostaglandin D2 and adenosinergically-induced sleep. J Neurochem. 2008 May; 105(4):1480-98. PMID: 18331290.
    Citations: 2     Fields:    Translation:Animals
  25. Blanco-Centurion C, Gerashchenko D, Shiromani PJ. Effects of saporin-induced lesions of three arousal populations on daily levels of sleep and wake. J Neurosci. 2007 Dec 19; 27(51):14041-8. PMID: 18094243.
    Citations: 66     Fields:    Translation:AnimalsCells
  26. Blanco-Centurion C, Xu M, Murillo-Rodriguez E, Gerashchenko D, Shiromani AM, Salin-Pascual RJ, Hof PR, Shiromani PJ. Adenosine and sleep homeostasis in the Basal forebrain. J Neurosci. 2006 Aug 02; 26(31):8092-100. PMID: 16885223; PMCID: PMC6673779.
    Citations: 62     Fields:    Translation:AnimalsCells
  27. Gerashchenko D, Chou TC, Blanco-Centurion CA, Saper CB, Shiromani PJ. Effects of lesions of the histaminergic tuberomammillary nucleus on spontaneous sleep in rats. Sleep. 2004 Nov 01; 27(7):1275-81. PMID: 15586780.
    Citations: 28     Fields:    Translation:AnimalsCells
  28. Gerashchenko D, Shiromani PJ. Effects of inflammation produced by chronic lipopolysaccharide administration on the survival of hypocretin neurons and sleep. Brain Res. 2004 Sep 03; 1019(1-2):162-9. PMID: 15306250.
    Citations: 13     Fields:    Translation:AnimalsCells
  29. Desarnaud F, Murillo-Rodriguez E, Lin L, Xu M, Gerashchenko D, Shiromani SN, Nishino S, Mignot E, Shiromani PJ. The diurnal rhythm of hypocretin in young and old F344 rats. Sleep. 2004 Aug 01; 27(5):851-6. PMID: 15453542.
    Citations: 36     Fields:    Translation:Animals
  30. Blanco-Centurion C, Gerashchenko D, Salin-Pascual RJ, Shiromani PJ. Effects of hypocretin2-saporin and antidopamine-beta-hydroxylase-saporin neurotoxic lesions of the dorsolateral pons on sleep and muscle tone. Eur J Neurosci. 2004 May; 19(10):2741-52. PMID: 15147308; PMCID: PMC1201541.
    Citations: 18     Fields:    Translation:AnimalsCells
  31. Shiromani PJ, Xu M, Winston EM, Shiromani SN, Gerashchenko D, Weaver DR. Sleep rhythmicity and homeostasis in mice with targeted disruption of mPeriod genes. Am J Physiol Regul Integr Comp Physiol. 2004 Jul; 287(1):R47-57. PMID: 15031135.
    Citations: 55     Fields:    Translation:Animals
  32. Gerashchenko D, Shiromani PJ. Different neuronal phenotypes in the lateral hypothalamus and their role in sleep and wakefulness. Mol Neurobiol. 2004 Feb; 29(1):41-59. PMID: 15034222.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  33. Gerashchenko D, Murillo-Rodriguez E, Lin L, Xu M, Hallett L, Nishino S, Mignot E, Shiromani PJ. Relationship between CSF hypocretin levels and hypocretin neuronal loss. Exp Neurol. 2003 Dec; 184(2):1010-6. PMID: 14769395.
    Citations: 32     Fields:    Translation:AnimalsCells
  34. Scammell TE, Gerashchenko DY, Mochizuki T, McCarthy MT, Estabrooke IV, Sears CA, Saper CB, Urade Y, Hayaishi O. An adenosine A2a agonist increases sleep and induces Fos in ventrolateral preoptic neurons. Neuroscience. 2001; 107(4):653-63. PMID: 11720788.
    Citations: 63     Fields:    Translation:AnimalsCells
  35. Gerashchenko DY, Beuckmann CT, Marcheselli VL, Gordon WC, Kanaoka Y, Eguchi N, Urade Y, Hayaishi O, Bazan NG. Localization of lipocalin-type prostaglandin D synthase (beta-trace) in iris, ciliary body, and eye fluids. Invest Ophthalmol Vis Sci. 1998 Jan; 39(1):198-203. PMID: 9430563.
    Citations: 11     Fields:    Translation:Animals
  36. Beuckmann CT, Gordon WC, Kanaoka Y, Eguchi N, Marcheselli VL, Gerashchenko DY, Urade Y, Hayaishi O, Bazan NG. Lipocalin-type prostaglandin D synthase (beta-trace) is located in pigment epithelial cells of rat retina and accumulates within interphotoreceptor matrix. J Neurosci. 1996 Oct 01; 16(19):6119-24. PMID: 8815894.
    Citations: 17     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.