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Maria A. Franceschini, Ph.D.

TitleAssociate Professor of Radiology
InstitutionMassachusetts General Hospital
DepartmentRadiology
AddressMassachusetts General Hospital
Radiology 2nd Floor Rm 2301
149 13th Street
Charlestown MA 02129
Phone617/726-4024
Fax617/726-7422
vCardDownload vCard (login for email)
Other Positions
TitleMember of the Affiliated Faculty of the Harvard-MIT Division of Health Sciences and Technology
InstitutionMassachusetts Institute of Technology
DepartmentHealth Sciences and Technology


 Bibliographic 
 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Devor A, Bandettini PA, Boas DA, Bower JM, Buxton RB, Cohen LB, Dale AM, Einevoll GT, Fox PT, Franceschini MA, Friston KJ, Fujimoto JG, Geyer MA, Greenberg JH, Halgren E, Hämäläinen MS, Helmchen F, Hyman BT, Jasanoff A, Jernigan TL, Judd LL, Kim SG, Kleinfeld D, Kopell NJ, Kutas M, Kwong KK, Larkum ME, Lo EH, Magistretti PJ, Mandeville JB, Masliah E, Mitra PP, Mobley WC, Moskowitz MA, Nimmerjahn A, Reynolds JH, Rosen BR, Salzberg BM, Schaffer CB, Silva GA, So PT, Spitzer NC, Tootell RB, Van Essen DC, Vanduffel W, Vinogradov SA, Wald LL, Wang LV, Weber B, Yodh AG. The challenge of connecting the dots in the B.R.A.I.N. Neuron. 2013 Oct 16; 80(2):270-4.
    View in: PubMed
  2. Dehaes M, Aggarwal A, Lin PY, Rosa Fortuno C, Fenoglio A, Roche-Labarbe N, Soul JS, Franceschini MA, Grant PE. Cerebral oxygen metabolism in neonatal hypoxic ischemic encephalopathy during and after therapeutic hypothermia. J Cereb Blood Flow Metab. 2014 Jan; 34(1):87-94.
    View in: PubMed
  3. Lin PY, Roche-Labarbe N, Dehaes M, Carp S, Fenoglio A, Barbieri B, Hagan K, Grant PE, Franceschini MA. Non-invasive optical measurement of cerebral metabolism and hemodynamics in infants. J Vis Exp. 2013; (73):e4379.
    View in: PubMed
  4. Roche-Labarbe N, Fenoglio A, Radhakrishnan H, Kocienski-Filip M, Carp SA, Dubb J, Boas DA, Grant PE, Franceschini MA. Somatosensory evoked changes in cerebral oxygen consumption measured non-invasively in premature neonates. Neuroimage. 2014 Jan 15; 85 Pt 1:279-86.
    View in: PubMed
  5. Lin PY, Roche-Labarbe N, Dehaes M, Fenoglio A, Grant PE, Franceschini MA. Regional and hemispheric asymmetries of cerebral hemodynamic and oxygen metabolism in newborns. Cereb Cortex. 2013 Feb; 23(2):339-48.
    View in: PubMed
  6. Laxminarayan S, Tadmor G, Diamond SG, Miller E, Franceschini MA, Brooks DH. Modeling habituation in rat EEG-evoked responses via a neural mass model with feedback. Biol Cybern. 2011 Dec; 105(5-6):371-97.
    View in: PubMed
  7. Devor A, Sakadžic S, Srinivasan VJ, Yaseen MA, Nizar K, Saisan PA, Tian P, Dale AM, Vinogradov SA, Franceschini MA, Boas DA. Frontiers in optical imaging of cerebral blood flow and metabolism. J Cereb Blood Flow Metab. 2012 Jul; 32(7):1259-76.
    View in: PubMed
  8. Zimmermann BB, Roche-Labarbe N, Surova A, Boas DA, Wolf M, Grant PE, Franceschini MA. The confounding effect of systemic physiology on the hemodynamic response in newborns. Adv Exp Med Biol. 2012; 737:103-9.
    View in: PubMed
  9. Boas DA, Franceschini MA. Haemoglobin oxygen saturation as a biomarker: the problem and a solution. Philos Trans A Math Phys Eng Sci. 2011 Nov 28; 369(1955):4407-24.
    View in: PubMed
  10. Roche-Labarbe N, Fenoglio A, Aggarwal A, Dehaes M, Carp SA, Franceschini MA, Grant PE. Near-infrared spectroscopy assessment of cerebral oxygen metabolism in the developing premature brain. J Cereb Blood Flow Metab. 2012 Mar; 32(3):481-8.
    View in: PubMed
  11. Carp SA, Roche-Labarbe N, Franceschini MA, Srinivasan VJ, Sakadžic S, Boas DA. Due to intravascular multiple sequential scattering, Diffuse Correlation Spectroscopy of tissue primarily measures relative red blood cell motion within vessels. Biomed Opt Express. 2011 Jul 1; 2(7):2047-54.
    View in: PubMed
  12. Dehaes M, Grant PE, Sliva DD, Roche-Labarbe N, Pienaar R, Boas DA, Franceschini MA, Selb J. Assessment of the frequency-domain multi-distance method to evaluate the brain optical properties: Monte Carlo simulations from neonate to adult. Biomed Opt Express. 2011; 2(3):552-67.
    View in: PubMed
  13. Radhakrishnan H, Wu W, Boas D, Franceschini MA. Study of neurovascular coupling by modulating neuronal activity with GABA. Brain Res. 2011 Feb 4; 1372:1-12.
    View in: PubMed
  14. Franceschini MA, Radhakrishnan H, Thakur K, Wu W, Ruvinskaya S, Carp S, Boas DA. The effect of different anesthetics on neurovascular coupling. Neuroimage. 2010 Jul 15; 51(4):1367-77.
    View in: PubMed
  15. Roche-Labarbe N, Carp SA, Surova A, Patel M, Boas DA, Grant PE, Franceschini MA. Noninvasive optical measures of CBV, StO(2), CBF index, and rCMRO(2) in human premature neonates' brains in the first six weeks of life. Hum Brain Mapp. 2010 Mar; 31(3):341-52.
    View in: PubMed
  16. Muehlschlegel S, Selb J, Patel M, Diamond SG, Franceschini MA, Sorensen AG, Boas DA, Schwamm LH. Feasibility of NIRS in the neurointensive care unit: a pilot study in stroke using physiological oscillations. Neurocrit Care. 2009; 11(2):288-95.
    View in: PubMed
  17. Grant PE, Roche-Labarbe N, Surova A, Themelis G, Selb J, Warren EK, Krishnamoorthy KS, Boas DA, Franceschini MA. Increased cerebral blood volume and oxygen consumption in neonatal brain injury. J Cereb Blood Flow Metab. 2009 Oct; 29(10):1704-13.
    View in: PubMed
  18. Huppert TJ, Diamond SG, Franceschini MA, Boas DA. HomER: a review of time-series analysis methods for near-infrared spectroscopy of the brain. Appl Opt. 2009 Apr 1; 48(10):D280-98.
    View in: PubMed
  19. Ou W, Nissilä I, Radhakrishnan H, Boas DA, Hämäläinen MS, Franceschini MA. Study of neurovascular coupling in humans via simultaneous magnetoencephalography and diffuse optical imaging acquisition. Neuroimage. 2009 Jul 1; 46(3):624-32.
    View in: PubMed
  20. Radhakrishnan H, Vanduffel W, Deng HP, Ekstrom L, Boas DA, Franceschini MA. Fast optical signal not detected in awake behaving monkeys. Neuroimage. 2009 Apr 1; 45(2):410-9.
    View in: PubMed
  21. Pratesi L, Paolucci S, Albuzza M, Franceschini M. Exploring the use of ''Protocollo di Minima per l'ictus - PMIC'': preliminary data in two Italian rehabilitation units. Eur J Phys Rehabil Med. 2008 Sep; 44(3):271-5.
    View in: PubMed
  22. Surova A, Grant EP, Selb J, Warren E, Roche-Labarbe N, Franceschini MA. Detection and Follow-up of Neonatal Brain Injuries with FD-NIRS. Proceedings of OSA, Biomedical Optics. 2008; BSuD1.
  23. Franceschini MA, Nissilä I, Wu W, Diamond SG, Bonmassar G, Boas DA. Coupling between somatosensory evoked potentials and hemodynamic response in the rat. Neuroimage. 2008 Jun; 41(2):189-203.
    View in: PubMed
  24. Radhakrishnan H, Deng H, Ekstrom L, Vanduffel W, Franceschini MA. Fast optical signal not detected in awake behaving monkeys. Proceedings of OSA, Biomedical Optics. 2008; BMD5.
  25. Carp SA, Kim YR, Dai G, Boas DA, Franceschini MA. Validation of Optical Measurements of Cerebral Blood Flow and Volume with SPION and ASL fMRI. Proceeding of OSA, Biomedical Optics. 2008; BMD2.
  26. Selb J, Muehlschlege S, Diamond SG, Franceschini MA, Schwamm LH, Boas DA. Disruption of Dynamic Cerebral Autoregulation in Ischemic Stroke Patients Assessed by Continuous-Wave NIRS. Proceedings of OSA, Biomedical Optics. 2008; BSuD4.
  27. Selb J, Boas DA, Grant E, Franceschini MA. Accuracy of the Frequency-Domain Multi-Distance Method to Retrieve the Brain Absorption Coefficient at Different Ages: Monte-Carlo Simulations. Proceedings of OSA, Biomedical Optics. 2008; BSuE72.
  28. Radhakrishnan H, Wu W, Carp S, Boas DA, Franceschini MA. Effect of GABA on somatosensory evoked potentials and hemodynamic evoked responses. Proceedings of OSA, Biomedical Optics. 2008; BTuE1.
  29. Ou W, Nissila I, Radhakrishnan H, Boas DA, Hamalainen MS, Franceschini MA. Study of Neurovascular Coupling via Simultaneous MEG DOI Acquisition. Proceedings of OSA, Biomedical Optics. 2008; BWC5.
  30. Franceschini M, Ferrari G, Raheli R, Meli F, Castoldi A. Post-detection nonlinear distortion for efficient MLSD in optical links. Opt Express. 2007 Sep 3; 15(18):11750-5.
    View in: PubMed
  31. Franceschini MA, Thaker S, Themelis G, Krishnamoorthy KK, Bortfeld H, Diamond SG, Boas DA, Arvin K, Grant PE. Assessment of infant brain development with frequency-domain near-infrared spectroscopy. Pediatr Res. 2007 May; 61(5 Pt 1):546-51.
    View in: PubMed
  32. Themelis G, D'Arceuil H, Diamond SG, Thaker S, Huppert TJ, Boas DA, Franceschini MA. Near-infrared spectroscopy measurement of the pulsatile component of cerebral blood flow and volume from arterial oscillations. J Biomed Opt. 2007 Jan-Feb; 12(1):014033.
    View in: PubMed
  33. Joseph DK, Huppert TJ, Franceschini MA, Boas DA. Diffuse optical tomography system to image brain activation with improved spatial resolution and validation with functional magnetic resonance imaging. Appl Opt. 2006 Nov 1; 45(31):8142-51.
    View in: PubMed
  34. Huppert TJ, Hoge RD, Dale AM, Franceschini MA, Boas DA. Quantitative spatial comparison of diffuse optical imaging with blood oxygen level-dependent and arterial spin labeling-based functional magnetic resonance imaging. J Biomed Opt. 2006 Nov-Dec; 11(6):064018.
    View in: PubMed
  35. Franceschini MA, Joseph DK, Huppert TJ, Diamond SG, Boas DA. Diffuse optical imaging of the whole head. J Biomed Opt. 2006 Sep-Oct; 11(5):054007.
    View in: PubMed
  36. Boas DA, Franceschini MA, Fantini S. Method for Measuring Venous Oxygen Saturation. 2006.
  37. Grant EP, Themelis G, Arvin K, Thaker S, Krishnamoorthy KK, Bortfeld H, Franceschini MA. Alterations in Regional Oxygen Saturation (StO2) and Blood Volume (HbT) in Infants with Brain Injuries and ECMO. Proceedings of OSA, Biomedical Topical Meeting. 2006; SC6.
  38. Themelis G, D'Arceuil H, Diamond SG, Thaker S, Huppert TJ, Boas DA, Franceschini MA. NIRS Measurement of Pulsatile Component of Cerebral Blood Flow and Volume from the Arterial Oscillations. Proceedings of OSA, Biomedical Topical Meeting. 2006; SC6.
  39. Franceschini MA, Nissila I, Wu W, Bonmassar G, Boas DA. Neurovascular Coupling in the Rat Somatosensory Cortex: A Non-Invasive Diffuse Optical Imaging and Electroencephalography Study. Proceedings of OSA, Biomedical Topical Meeting. 2006.
  40. Nissila I, Stufflebeam S, Diamond SG, Huppert TJ, Hamalainen M, Franceschini MA. Responses to Median Nerve Stimulation as Recorded by Simultaneous Diffuse Optical Imaging and Magnetoencephalography. Proceedings of OSA, Biomedical Topical Meeting. 2006.
  41. Joseph DK, Huppert TJ, Franceschini MA, Boas DA. Design and Validation of a Diffuse Optical Tomography System with Improved Spatial Resolution for Functional Brain Imaging. Proceedings of OSA, Biomedical Topical Meeting. 2006.
  42. Huppert TJ, Hoge RD, Diamond SG, Franceschini MA, Boas DA. A temporal comparison of BOLD, ASL, and NIRS hemodynamic responses to motor stimuli in adult humans. Neuroimage. 2006 Jan 15; 29(2):368-82.
    View in: PubMed
  43. Diamond SG, Huppert TJ, Kolehmainen V, Franceschini MA, Kaipio JP, Arridge SR, Boas DA. Dynamic physiological modeling for functional diffuse optical tomography. Neuroimage. 2006 Mar; 30(1):88-101.
    View in: PubMed
  44. Culver JP, Siegel AM, Franceschini MA, Mandeville JB, Boas DA. Evidence that cerebral blood volume can provide brain activation maps with better spatial resolution than deoxygenated hemoglobin. Neuroimage. 2005 Oct 1; 27(4):947-59.
    View in: PubMed
  45. Hoge RD, Franceschini MA, Covolan RJ, Huppert T, Mandeville JB, Boas DA. Simultaneous recording of task-induced changes in blood oxygenation, volume, and flow using diffuse optical imaging and arterial spin-labeling MRI. Neuroimage. 2005 Apr 15; 25(3):701-7.
    View in: PubMed
  46. Zhang Y, Brooks DH, Franceschini MA, Boas DA. Eigenvector-based spatial filtering for reduction of physiological interference in diffuse optical imaging. J Biomed Opt. 2005 Jan-Feb; 10(1):11014.
    View in: PubMed
  47. Themelis G, D'Arceuil H, Thaker S, Diamond SG, Franceschini MA. Cerebral blood flow and volume measurement in piglets using CW NIRS system. Proceedings of ECBO. 2005.
  48. Diamond SG, Huppert TJ, Kolehmainen V, Franceschini MA, Kaipio JP, Arridge SR, Boas DA. Physiological system identification with the Kalman filter in diffuse optical tomography. Med Image Comput Comput Assist Interv. 2005; 8(Pt 2):649-56.
    View in: PubMed
  49. D'Arceuil HE, Hotakainen MP, Liu C, Themelis G, de Crespigny AJ, Franceschini MA. Near-infrared frequency-domain optical spectroscopy and magnetic resonance imaging: a combined approach to studying cerebral maturation in neonatal rabbits. J Biomed Opt. 2005 Jan-Feb; 10(1):11011.
    View in: PubMed
  50. Thaker S, Chaves T, Themelis G, Almeida P, Krishnamoorthy K, Arvin K, Grant E, Franceschini MA. NIRS measurements of cerebral hemoglobin concentration and oxygenation in neonates. Proceedings of ECBO. 2005.
  51. Selb J, Stott JJ, Franceschini MA, Sorensen AG, Boas DA. Improved sensitivity to cerebral hemodynamics during brain activation with a time-gated optical system: analytical model and experimental validation. J Biomed Opt. 2005 Jan-Feb; 10(1):11013.
    View in: PubMed
  52. Diamond SG, Huppert TJ, Kolehmainen V, Franceschini MA, Kaipio JP, Arridge SR, and Boas DA. Physiological System Identification with the Kalman Filter in Diffuse Optical Tomography. Proceedings of Lecture Notes in Computer Science, MICCAI 3750. 2005; 3750:649-56.
  53. Boas DA, Chen K, Grebert D, Franceschini MA. Improving the diffuse optical imaging spatial resolution of the cerebral hemodynamic response to brain activation in humans. Opt Lett. 2004 Jul 1; 29(13):1506-8.
    View in: PubMed
  54. Quaresima V, Ferrari M, Franceschini MA, Hoimes ML, Fantini S. Spatial distribution of vastus lateralis blood flow and oxyhemoglobin saturation measured at the end of isometric quadriceps contraction by multichannel near-infrared spectroscopy. J Biomed Opt. 2004 Mar-Apr; 9(2):413-20.
    View in: PubMed
  55. Themelis G, Selb J, Thaker S, Stott JJ, Custo A, Boas DA, Franceschini MA. Depth of arterial oscillation resolved with NIRS time and frequency domain. Proceedings of OSA, Biomedical Topical Meeting. 2004; WF2.
  56. Franceschini MA, Boas DA. Noninvasive measurement of neuronal activity with near-infrared optical imaging. Neuroimage. 2004 Jan; 21(1):372-86.
    View in: PubMed
  57. D'Arceuil HE, Hotakainen MP, Liu C, De Crespigny A, Franceschini MA. Postnatal Brain Maturation in Rabbits Studied by Combined NIRS and MRI. Proceedings of ISMRM, 12th Scientific Meeting. 2004.
  58. Franceschini MA, Andre CJ, Huppert TJ, Joseph D, Stott J, and Boas DA. Diffuse optical imaging of the whole head. Proceedings of HBM, 10th Annual Meeting of the Organization for Human Brain Mapping, conference on Functional Mapping of the Human Brain, Neuroimage 22. 2004; 22(supplement 1).
  59. Huppert TJ, Hoge RD, Franceschini MA, Boas DA. A Temporal Comparison of Simultaneously Acquired BOLD fMRI and Near-Infrared Spectroscopy(NIRS) Hemodynamic Response Functions. Proceedings of HBM, 10th Annual Meeting of the Organization for Human Brain Mapping, conference on Functional Mapping of the Human Brain, Neuroimage 22. 2004; (supplement 1):24.
  60. Selb J, Stott JJ, Franceschini MA, and Boas DA. Improvement of depth sensitivity to cerebral hemodynamics with a time domain system. Proceedings if OSA, Biomedical Topical Meeting. 2004; FC3.
  61. Huppert TJ, Hoge RD, Franceschini MA, Boas DA. Calculation of task-evoked changes in the cerebral metabolic rate of oxygen consumption from simultaneous. Proceedings of OSA, Biomedical Topical Meeting. 2004; WF4.
  62. Boas DA, Dale AM, Franceschini MA. Diffuse optical imaging of brain activation: approaches to optimizing image sensitivity, resolution, and accuracy. Neuroimage. 2004; 23 Suppl 1:S275-88.
    View in: PubMed
  63. Zhang Y, Brooks DH, Franceschini MA, Boas DA. Improved localization of evoked hemodynamic response in diffuse optical functional imaging using a spatial subspace approach. Proceedings of OSA, Biomedical Topical Meeting. 2004; WF3.
  64. Fabbri F, Henry ME, Renshaw PF, Nadgir S, Ehrenberg BL, Franceschini MA, Fantini S. Bilateral near-infrared monitoring of the cerebral concentration and oxygen-saturation of hemoglobin during right unilateral electro-convulsive therapy. Brain Res. 2003 Dec 5; 992(2):193-204.
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  65. Franceschini MA, Fantini S, Thompson JH, Culver JP, Boas DA. Hemodynamic evoked response of the sensorimotor cortex measured noninvasively with near-infrared optical imaging. Psychophysiology. 2003 Jul; 40(4):548-60.
    View in: PubMed
  66. Prince S, Kolehmainen V, Kaipio JP, Franceschini MA, Boas D, Arridge SR. Time-series estimation of biological factors in optical diffusion tomography. Phys Med Biol. 2003 Jun 7; 48(11):1491-504.
    View in: PubMed
  67. Fabbri F, Franceschini MA, Fantini S. Characterization of spatial and temporal variations in the optical properties of tissuelike media with diffuse reflectance imaging. Appl Opt. 2003 Jun 1; 42(16):3063-72.
    View in: PubMed
  68. Strangman G, Franceschini MA, Boas DA. Factors affecting the accuracy of near-infrared spectroscopy concentration calculations for focal changes in oxygenation parameters. Neuroimage. 2003 Apr; 18(4):865-79.
    View in: PubMed
  69. Wolf M, Franceschini MA, Paunescu LA, Toronov V, Michalos A, Wolf U, Gratton E, Fantini S. Absolute frequency-domain pulse oximetry of the brain: methodology and measurements. Adv Exp Med Biol. 2003; 530:61-73.
    View in: PubMed
  70. Strangman G, Franceschini MA, Boas DA. Factors affecting the accuracy of near-infrared spectroscopy concentration calculations for focal changes in hemodynamics. NeuroImage. 2003; 18:865-79.
  71. Wolf M, Franceschini MA, Paunescu LA, Toronov V, Michalos A, Wolf U, Gratton E, Fantini S. Absolute frequency-domain pulse oximetry of the brain: Methodology and measurements. Adv. Exp. Med. Bio. 2003; 536:61-74.
  72. Culver JP, Siegel A, Franceschini MA, Marota JJ, Mandeville JB, Boas DA. Which hemodynamic contrast best localizes neuronal activity?. Proceedings of OSA, Biomedical Topical Meeting. 2002; 41-3.
  73. Culver JP, Siegel A, Franceschini MA, Marota JJ, Mandeville JB, Boas DA. Which hemodynamic contrast best localizes neuronal activity? A diffuse optical tomography study. Proceedings of ISMRM, 10th Scientific Meeting. 2002; Abstract # 650.
  74. Franceschini MA, Thompson J, Culver JP, Strangman G, Boas DA. Looking for the fast signal: Neuronal and hemodynamic evoked responses of the sensory-motor cortex. Proceedings of OSA, Biomedical Topical Meeting. 2002; 208-10.
  75. Nadgir S, Fantini S, Renshaw PF, Henry M, Franceschini MA. Monitoring cerebral hemodynamic using near-infrared spectroscopy during electro-convulsive therapy. Proceedings of OSA, Biomedical Topical Meeting. 2002; 167-9.
  76. Franceschini MA, Boas DA, Zourabian A, Diamond SG, Nadgir S, Lin DW, Moore JB, Fantini S. Near-infrared spiroximetry: noninvasive measurements of venous saturation in piglets and human subjects. J Appl Physiol (1985). 2002 Jan; 92(1):372-84.
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  77. Aggarwal P, Chen K, Franceschini MA, Ehrenberg B, Fantini S. Concurrent cerebral near-infrared spectroscopy and electroencephalography during all-night sleep. Proceedings of OSA, Biomedical Topical Meeting. 2002; 297-9.
  78. Boas DA, Franceschini MA, Dunn AK, Strangman G. Non-invasive imaging of cerebral activation with diffuse optical tomography. R.D. Frostig, editor. In Vivo Optical Imaging of Brain Function. 2002; 193-221.
  79. Fantini S, and Franceschini MA. Frequency-domain techniques for tissue spectroscopy and imaging. V.V. Tuchin, editor. Handbook of Optical Biomedical Diagnostics. 2002; (Chapter 7):405-53.
  80. Franceschini MA, Fantini S, Gratton E. Method for Measuring Absolute Saturation of Time-Varying and Other Hemoglobin Compartments. 2001.
  81. Gratton E, Fantini S, Franceschini MA, Mantulin WW, Barbieri B. Photosensor with Multiple Light Sources. Continuation in part. 2001.
  82. Hueber DM, Franceschini MA, Ma HY, Zhang Q, Ballesteros JR, Fantini S, Wallace D, Ntziachristos V, Chance B. Non-invasive and quantitative near-infrared haemoglobin spectrometry in the piglet brain during hypoxic stress, using a frequency-domain multidistance instrument. Phys Med Biol. 2001 Jan; 46(1):41-62.
    View in: PubMed
  83. Franceschini MA, Zourabian A, Moore JB, Arora A, Fantini S, and Boas DA. Local measurement of venous saturation in tissue with non-invasive, near-infrared respiratory-oximetry. Proceedings SPIE 4250. 2001; 4250:164-70.
  84. Toronov V, Franceschini MA, Filiaci M, Fantini S, Wolf M, Michalos A, Gratton E. Near-infrared study of fluctuations in cerebral hemodynamics during rest and motor stimulation: temporal analysis and spatial mapping. Med Phys. 2000 Apr; 27(4):801-15.
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  85. Stankovic MR, Maulik D, Rosenfeld W, Stubblefield PG, Kofinas AD, Gratton E, Franceschini MA, Fantini S, Hueber DM. Role of frequency domain optical spectroscopy in the detection of neonatal brain hemorrhage--a newborn piglet study. J Matern Fetal Med. 2000 Mar-Apr; 9(2):142-9.
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  86. Franceschini MA, Toronov V, Filiaci M, Gratton E, Fantini S. On-line optical imaging of the human brain with 160-ms temporal resolution. Opt Express. 2000 Jan 31; 6(3):49-57.
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  87. Franceschini MA, Fantini S, Toronov V, Filiaci ME, Gratton E. Cerebral Hemodynamics Measured by Near-Infrared Spectroscopy at Rest and During Motor Activation. Proceedings of OSA, In Vivo Optical Imaging. 2000; 73-80.
  88. Franceschini MA, Toronov V, Filiaci M, Wolf M, Michalos A, Gratton E, and Fantini S. Real-time video of brain activation in human subjects using a non-invasive near-infrared technique. Proceedings of OSA, Advances in Optical Imaging and Photon Migration, Topical Meeting. 2000; 265-67.
  89. Fantini S, Heffer EL, Franceschini MA, Gotz L, Heinig A, Heywang-Kobrunner S, Schutz O, Siebold H. Optical Mammography with Intensity-Modulated Light. Proceedings of OSA, In Vivo Optical Imaging. 2000; 111-7.
  90. Fantini S, Franceschini MA. Tomografia Ottica (Optical Tomography). 2000.
  91. Heffer EL, Franceschini MA, Fantini S, Heywang-Kobrunner S, Gotz L, Heinig A, Schutz O, Siebold H. Analysis of Frequency-Domain Optical Mammograms Using Spectral Information. Proceedings of OSA, Advances in Optical Imaging and Photon Migration, Topical Meeting. 2000; 401-2.
  92. Fantini S, Franceschini MA, Hueber DM, Quistorff B, Greisen G, Brun NC, Ballesteros J, Zhang Q, Ma H, Ntziachristos V, and Chance B. Quantitative optical monitoring of the hemoglobin concentration and saturation in the piglet brain. Proceedings of OSA, Advances in Optical Imaging and Photon Migration, Topical Meeting. 2000; 457.
  93. Franceschini MA, Gratton E, Fantini S. Noninvasive optical method of measuring tissue and arterial saturation: an application to absolute pulse oximetry of the brain. Opt Lett. 1999 Jun 15; 24(12):829-31.
    View in: PubMed
  94. Fantini S, Hueber D, Franceschini MA, Gratton E, Rosenfeld W, Stubblefield PG, Maulik D, Stankovic MR. Non-invasive optical monitoring of the newborn piglet brain using continuous-wave and frequency-domain spectroscopy. Phys Med Biol. 1999 Jun; 44(6):1543-63.
    View in: PubMed
  95. Fantini S, Franceschini M, Gratton E, Hueber D, Rosenfeld W, Maulik D, Stubblefield P, Stankovic M. Non-invasive optical mapping of the piglet brain in real time. Opt Express. 1999 Apr 12; 4(8):308-14.
    View in: PubMed
  96. Stankovic MR, Maulik D, Rosenfeld W, Stubblefield PG, Kofinas AD, Drexler S, Nair R, Franceschini MA, Hueber D, Gratton E, Fantini S. Real-time optical imaging of experimental brain ischemia and hemorrhage in neonatal piglets. J Perinat Med. 1999; 27(4):279-86.
    View in: PubMed
  97. Casavola C, Paunescu LA, Fantini S, Franceschini MA, Lugarà PM, Gratton E. Application of near-infrared tissue oxymetry to the diagnosis of peripheral vascular disease. Clin Hemorheol Microcirc. 1999; 21(3-4):389-93.
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  98. Paunescu LA, Casavola C, Franceschini MA, Fantini S, Winter L, Kim J, Wood D, and Gratton E. Calf muscle blood flow and oxygen consumption measured with near-infrared spectroscopy during venous occlusion. Proceedings SPIE 3597. 1999; 3597:317-23.
  99. Fantini S, Schutz O, Edler J, Heywang-Kobrunner S, Gotz L, Franceschini MA, and Siebold H. Clinical Applications of Frequency-Domain Optical Mammography. Proceedings SPIE 3566. 1999; 3566:194-9.
  100. Franceschini MA, Gratton E, Hueber DM, and Fantini S. Near-infrared Absorption and Scattering Spectra of Tissues in Vivo. Proceedings SPIE 3597. 1999; 3597:526-31.
  101. Toronov V, Filiaci M, Franceschini MA, Fantini S, and Gratton E. Photon-density-wave fluctuation-correlation-spectroscopy: study of coherence in the brain and muscles. Proceedings SPIE 3597. 1999; 3597:244-51.
  102. Stankovic MR, Hueber DM, Maulik D, P, Stubblefield G, Rosenfeld W, Gratton E, Franceschini MA, and Fantini S. Real-Time Optical Imaging and Spectroscopy of Brain Ischemia and Hemorrhage. Proceedings SPIE 3597. 1999; 3597:676-84.
  103. Casavola C, Paunescu LA, Franceschini MA, Fantini S, Winter L, Kim J, Wood D, and Gratton E. Near-infrared spectroscopy and tilting table protocol: a novel method to study the blood flow and the oxygen consumption in tissue. Proceedings SPIE 3597. 1999; 3597:685-92.
  104. Franceschini MA, Fantini S, Paunescu LA, Maier JS, Gratton E. Influence of a superficial layer in the quantitative spectroscopic study of strongly scattering media. Appl Opt. 1998 Nov 1; 37(31):7447-58.
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  105. Gratton E, Fantini S, Franceschini MA, Mantulin WW, Barbieri B. Photosensor with Multiple Light Sources. Continuation in part. 1998.
  106. Fantini S, Walker SA, Franceschini MA, Kaschke M, Schlag PM, Moesta KT. Assessment of the size, position, and optical properties of breast tumors in vivo by noninvasive optical methods. Appl Opt. 1998 Apr 1; 37(10):1982-9.
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  107. Moesta KT, Fantini S, Jess H, Totkas S, Franceschini MA, Kaschke M, Schlag PM. Contrast features of breast cancer in frequency-domain laser scanning mammography. J Biomed Opt. 1998 Apr; 3(2):129-36.
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  108. Paunescu LA, Franceschini MA, Fantini S, Cerussi AE, and Gratton E. Effective Optical Properties of Two-Layered Turbid Media Using the Frequency-Domain Multi-Distance Method. Proceedings of OSA, Trends in Optics and Photonics on Advances in Optical Imaging and Photon Migration 21. 1998; 21:79-83.
  109. Quaresima V, Franceschini MA, Fantini S, Gratton E, and Ferrari M. Difference in Leg Muscles Oxygenation During Treadmill Exercise by a New Near-Infrared Frequency-Domain Oximeter. Proceedings SPIE 3194. 1998; 3194:116-20.
  110. Franceschini MA, Paunescu LA, Fantini S, Pratesi S, Maier JS, Donzelli GP, and Gratton E. Frequency-Domain Optical Measurements in Vitro on Two-and Three-Layered Tissue-Like Phantoms and in Vivo on Infant Heads. Proceedings of OSA, Trends in Optics and Photonics on Advances in Optical Imaging and Photon Migration 21. 1998; 21:232-6.
  111. Fantini S, Walker SA, Franceschini MA, Moesta KT, Schlag PM, Kaschke M, and Gratton E. Optical Characterization of Breast Tumors by Frequency-Domain Optical Mammography. Proceedings of OSA, Trends in Optics and Photonics on Advances in Optical Imaging and Photon Migration 21. 1998; 21:289-93.
  112. Moesta KT, Jess H, Totkas S, Fantini S, Franceschini MA, Kaschke M, and Schlag PM. Contrast features of breast cancer in frequency-domain laser scanning mammography. J. Biomed. Opt. 1998; 3:129-36.
  113. Franceschini MA, Fantini S, Palumbo R, Pasqualini L, Vaudo G, Franceschini E, Gratton E, Palumbo B, Innocente S, and Mannarino E. Quantitative Near-Infrared Spectroscopy on Patients with Peripheral Vascular Disease. Proceedings SPIE 3194. 1998; 3194:112-5.
  114. Gratton E, Fantini S, Franceschini MA, Gratton G, Fabiani M. Measurements of scattering and absorption changes in muscle and brain. Philos Trans R Soc Lond B Biol Sci. 1997 Jun 29; 352(1354):727-35.
    View in: PubMed
  115. Franceschini MA, Moesta KT, Fantini S, Gaida G, Gratton E, Jess H, Mantulin WW, Seeber M, Schlag PM, Kaschke M. Frequency-domain techniques enhance optical mammography: initial clinical results. Proc Natl Acad Sci U S A. 1997 Jun 10; 94(12):6468-73.
    View in: PubMed
  116. Franceschini MA, Fantini S, Cerussi AE, Barbieri BB, Chance B, Gratton E. Quantitative spectroscopic determination of hemoglobin concentration and saturation in a turbid medium: analysis of the effect of water absorption. J Biomed Opt. 1997 Apr; 2(2):147-53.
    View in: PubMed
  117. Franceschini MA, Wallace D, Barbieri B, Fantini S, Mantulin WW, Pratesi S, Donzelli GP, and Gratton E. Optical Study of the Skeletal Muscle During Exercise with a Second Generation Frequency-Domain Tissue Oximeter. Proceeding SPIE 2979. 1997; 2979:807-14.
  118. Fantini S, Franceschini MA, and Gratton E. Effect of Spatially Distributed Light Sources on the Frequency-Domain Solution to the Diffusion Equation. Proceedings SPIE 2979. 1997; 2979:509-14.
  119. Fantini S, Franceschini MA, Gratton E. Effective source term in the diffusion equation for photon transport in turbid media. Appl Opt. 1997 Jan 1; 36(1):156-63.
    View in: PubMed
  120. Gratton E, Fantini S, Franceschini MA, Gratton G, and Fabiani M. Measurement of scattering and absorption changes in muscle and brain. Phil. Trans. R. Soc. of Lond. B. 1997; 352:727-35.
  121. Fantini S, Barbieri B, Franceschini MA, and Gratton E. Frequency-domain spectroscopy. E. Kohen, editor. Applications of Optical Engineering to the Study of Cellular Pathology. 1997; 57-66.
  122. Cerussi AE, Maier JS, Fantini S, Franceschini MA, Mantulin WW, Gratton E. Experimental verification of a theory for the time-resolved fluorescence spectroscopy of thick tissues. Appl Opt. 1997 Jan 1; 36(1):116-24.
    View in: PubMed
  123. Fantini S, Moesta KT, Franceschini MA, Jess H, Erdl H, Gratton E, Schlag PM, and Kaschke M. Instrumentation and Clinical Applications in Frequency-Domain Optical Mammography. Proceedings of 19th Int. Conf. IEEE/EMBS on Photon Migration Tomography MS21. 1997; MS21:2741-4.
  124. Franceschini MA, Moesta KT, Fantini S, Gaida G, Gratton E, Jess H, Mantulin WW, Seeber M, Schlag PM, and Kaschke M. Frequency-domain instrumentation enhances optical mammography: initial clinical results. Proc. Natl. Aca. Sci. USA. 1997; 2:147-53.
  125. Franceschini MA, Fantini S, Cerussi AE, Barbieri B, Chance B, and Gratton E. Quantitative spectroscopic determination of hemoglobin concentration and saturation in a turbid medium: analysis of the effect of water absorption. J. Biomed. Opt. 1997; 2:147-53.
  126. Gratton E, Fantini S, Franceschini MA, Mantulin WW, Barbieri B. Photosensor with Multiple Light Sources. 1996.
  127. Gratton E, Maier JS, Franceschini MA, Fantini S, Walker SA. Determining Material Concentrations in Tissues. 1996.
  128. Fantini S, Franceschini MA, Gaida G, Gratton E, Jess H, Mantulin WW, Moesta KT, Schlag PM, Kaschke M. Frequency-domain optical mammography: edge effect corrections. Med Phys. 1996 Jan; 23(1):149-57.
    View in: PubMed
  129. Cerussi AE, Maier JS, Fantini S, Franceschini MA, and Gratton E. The Frequency-Domain Multi-Distance Method in the Presence of Curved Boundaries. Proceedings of OSA, Trends in Optics and Photonics on Biomedical Optical Spectroscopy and Diagnostics 3. 1996; 3:92-7.
  130. Fantini S, Franceschini MA, Gaida G, Jess H, Erdl H, Mantulin WW, Gratton E, and Kaschke M. Contrast Enhancement by Edge Effect Corrections in Frequency-Domain Optical Mammography. Proceedings of OSA, Trends in Optics and Photonics on Advances in Optical Imaging and Photon Migration 2. 1996; 2:160-3.
  131. Franceschini MA, Fantini S, Cerussi AE, Barbieri B, Chance B, and Gratton E. The Effect of Water in the Quantitation of Hemoglobin Concentration in a Tissue-Like Phantom by Near-Infrared Spectroscopy. Proceedings of OSA, Trends in Optics and Photonics on Biomedical Optical Spectroscopy and Diagnostics 3. 1996; 3:126-30.
  132. Jess H, Erdl H, Moesta KT, Fantini S, Franceschini MA, Gratton E, and Kaschke M. Intensity-Modulated Breast Imaging: Technology and Clinical Pilot Study Results. Proceeding of OSA, Trends in Optics and Photonics on Advances in Optical Imaging and Photon Migration 2. 1996; 2:126-9.
  133. Maier JS, Cerussi AE, Fantini S, Franceschini MA, and Gratton E. Quantitative Fluorescence in Tissue-Like Media. Proceedings of OSA, Trends in Optics and Photonics on Advances in Optical Spectroscopy and Diagnostics 3. 1996; 3:206-9.
  134. Gratton E, Fantini S, Franceschini MA, Walker S, and Maier J. Spectroscopy and tomography of tissues in the frequency-domain. E. Kohen and J.G. Hirschberg, editors. Analytical Use of Fluorescent Probes in Oncology. NATO ASI Series, Series A: Life Sciences. 1996; 286:41-52.
  135. Fishkin JB, So PT, Cerussi AE, Fantini S, Franceschini MA, Gratton E. Frequency-domain method for measuring spectral properties in multiple-scattering media: methemoglobin absorption spectrum in a tissuelike phantom. Appl Opt. 1995 Mar 1; 34(7):1143-55.
    View in: PubMed
  136. De Blasi RA, Fantini S, Franceschini MA, Ferrari M, Gratton E. Cerebral and muscle oxygen saturation measurement by frequency-domain near-infra-red spectrometer. Med Biol Eng Comput. 1995 Mar; 33(2):228-30.
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  137. Gratton G, Fabiani M, Friedman D, Franceschini MA, Fantini S, Corballis PM, and Gratton E. Rapid changes of optical parameters in the human brain during a tapping task. J. Cognitive Neuroscience. 1995; 7:446-56.
  138. Fantini S, Franceschini MA, Gaida G, and Kaschke M. Frequency-Domain Optical Mammography: the Problem of Tissue thickness Variations within the Scanned Region. Proceedings SPIE 2626. 1995; 2626:228-36.
  139. Fantini S and Franceschini MA. Studio ottico di tessuti biologici nel vicino infrarosso: spettroscopia e tomografia (Optical study of biological tissues in the near-infrared: spectroscopy and tomography),. R. Pratesi, editor. Laser e Luce in Chirurgia e Medicina ed in Biotecnologia (Laser and Light in Surgery and Medicine and in Biotechnology). 1995; 415-26.
  140. Maier JS, Barbieri B, Chervu A, Chervu I, Fantini S, Franceschini MA, Levi M, Mantulin WW, Rosenberg A, Walker SA, Gratton E. In Vivo Study of Human Tissues with a Portable Near-Infrared Tissue Spectrometer and Oximeter. Proceedings SPIE 2387. 1995; 2387:240-48.
  141. Mantulin WW, Fantini S, Franceschini MA, Walker SA, Maier JS, and Gratton E. Tissue Optical Parameter Map Generated with Frequency-Domain Near-Infrared Spectroscopy. Proceedings SPIE 2396. 1995; 2396:323-30.
  142. Fantini S, Franceschini MA, Maier JS, Walker SA, Barbieri B, and Gratton E. Frequency-domain multichannel optical detector for non-invasive tissue spectroscopy and oximetry. Opt. Eng. 1995; 34:32-42.
  143. Gratton G, Fabiani M, Friedman D, Franceschini MA, Fantini S, Corballis P, Gratton E. Rapid changes of optical parameters in the human brain during a tapping task. J Cogn Neurosci. 1995; 7(4):446-56.
    View in: PubMed
  144. Ferrari M, De Blasi RA, Fantini S, Franceschini MA, Barbieri B, Quaresima V, and Gratton E. Cerebral and Muscle Oxygen Saturation Measurement by a Frequency-Domain Near-Infrared Spectroscopic Technique. Proceedings SPIE 2389. 1995; 2389:868-74.
  145. Franceschini MA, Fantini S, Walker SA, Maier JS, and Gratton E. Multi-Channel Optical Instrument for Near-Infrared Imaging of Tissue. Proceedings SPIE 2389. 1995; 2389:264-72.
  146. Fantini S, Franceschini MA, Walker SA, Maier JS, and Gratton E. Photon Path Distributions in Turbid Media: Applications for Imaging. Proceedings SPIE 2389. 1995; 2389:340-49.
  147. Fishkin JB, So PTC, Cerussi AE, Fantini S, Franceschini MA, and Gratton E. Frequency-domain method for determining spectral properties in multiply scattering media: methemoglobin absorption spectrum in a tissue-like phantom. Appl. Opt. 1995; 34:1143-55.
  148. Maier JS, Walker SA, Fantini S, Franceschini MA, Gratton E. Possible correlation between blood glucose concentration and the reduced scattering coefficient of tissues in the near infrared. Opt Lett. 1994 Dec 15; 19(24):2062-4.
    View in: PubMed
  149. Fantini S, Franceschini MA, Fishkin JB, Barbieri B, Gratton E. Quantitative determination of the absorption spectra of chromophores in strongly scattering media: a light-emitting-diode based technique. Appl Opt. 1994 Aug 1; 33(22):5204-13.
    View in: PubMed
  150. Fantini S, Franceschini MA, Maier JS, Walker SA, and Gratton E. Frequency-Domain Multi-Source Optical Spectrometer and Oximeter. Proceedings SPIE 2326. 1994; 2326:108-16.
  151. Gratton E, Fantini S, Franceschini MA, Fishkin JB, and Maier JS. Near-Infrared Optical Spectroscopy of tissues Using an LED Frequency Domain Spectrometer. Proceedings of OSA, Trends in Optics and Photonics on Advances in Optical Imaging and Photon Migration 21. 1994; 21:278-82.
  152. Fantini S, Franceschini MA, Fishkin JB, Barbieri B, Gratton E. Quantitative determination of the absorption spectra of chromophores in strongly scattering media: a light-emitting-diode based technique. Appl. Opt. 1994; 33:5204-13.
  153. Fantini S, Franceschini MA, Fishkin JB, and Gratton E. Absolute Measurement of Absorption and Scattering Coefficients Spectra of a Multiply Scattering Medium. Proceedings SPIE 2131. 1994; 2131:356-64.
  154. Fantini S, Franceschini MA, Fishkin JB, Mantulin WW and Gratton E. The Absorption Spectra of a Chromophore in Highly Scattering Media. Proceedings SPIE 2100. 1994; 2100:114-23.
  155. Franceschini MA, Fantini S, and Gratton E. LEDs in Frequency-Domain Spectroscopy of Tissues. Proceedings SPIE 2135. 1994; 2135:300-6.
  156. Fantini S, Franceschini MA, and Gratton E. Semi-infinite-geometry boundary problem for light migration in highly scattering media: a frequency-domain study in the diffusion approximation. J. Opt. Soc. Am. B. 1994; 11:2128-38.
  157. Franceschini MA, Pini R, Salimbeni R, Vannini M, Fu S. Long Pulse XeCl Laser in Auto-Prepulse: Characteristics and Perspectives. Proceedings SPIE 1810. 1992; 1810:435-38.
  158. Franceschini MA, Pini R, Salimbeni R, Vannini M. Auto-prepulse operation of a long-pulse XeCl laser. Appl. Physics B. 1992; 54:259-64.
  159. Benaim G, Mattioli S, Cremona M, Pini R, Salimbeni R, Vannini , Franceschini MA. In Vitro Tests of Excimer Laser Lithotripsy in Urinary Stones. Proceedings SPIE 1643. 1992; 1643:73-7.
  160. Franceschini MA, Fu S, Pini R, Salimbeni R, Vannini M. Auto Prepulse Operation of XeCl Scaled up Laser Prototype: Modeling and Achievements. Proceedings of Int. Conf. LASERS 1992. 1992; 146-51.
  161. Franceschini MA, Pini R, Salimbeni R, Vannini M. Long Pulse XeCl Laser: A New Simple Approach. Proceedings of Int. Conf. LASERS 1991. 1991; 713-21.
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