Harvard Catalyst Profiles

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Emery Neal Brown, Ph.D., M.D.

Co-Author

This page shows the publications co-authored by Emery Brown and Patrick Purdon.
Connection Strength

11.041
  1. Purdon PL, Sampson A, Pavone KJ, Brown EN. Clinical Electroencephalography for Anesthesiologists: Part I: Background and Basic Signatures. Anesthesiology. 2015 Oct; 123(4):937-60.
    View in: PubMed
    Score: 0.705
  2. Purdon PL, Zhou DW, Akeju O, Brown EN. In reply. Anesthesiology. 2015 Sep; 123(3):725-8.
    View in: PubMed
    Score: 0.701
  3. Purdon PL, Pavone KJ, Akeju O, Smith AC, Sampson AL, Lee J, Zhou DW, Solt K, Brown EN. The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia. Br J Anaesth. 2015 Jul; 115 Suppl 1:i46-i57.
    View in: PubMed
    Score: 0.692
  4. Brown EN, Purdon PL. The aging brain and anesthesia. Curr Opin Anaesthesiol. 2013 Aug; 26(4):414-9.
    View in: PubMed
    Score: 0.606
  5. Purdon PL, Pierce ET, Mukamel EA, Prerau MJ, Walsh JL, Wong KF, Salazar-Gomez AF, Harrell PG, Sampson AL, Cimenser A, Ching S, Kopell NJ, Tavares-Stoeckel C, Habeeb K, Merhar R, Brown EN. Electroencephalogram signatures of loss and recovery of consciousness from propofol. Proc Natl Acad Sci U S A. 2013 Mar 19; 110(12):E1142-51.
    View in: PubMed
    Score: 0.589
  6. Purdon PL, Pierce ET, Bonmassar G, Walsh J, Harrell PG, Kwo J, Deschler D, Barlow M, Merhar RC, Lamus C, Mullaly CM, Sullivan M, Maginnis S, Skoniecki D, Higgins HA, Brown EN. Simultaneous electroencephalography and functional magnetic resonance imaging of general anesthesia. Ann N Y Acad Sci. 2009 Mar; 1157:61-70.
    View in: PubMed
    Score: 0.446
  7. Stephen EP, Hotan GC, Pierce ET, Harrell PG, Walsh JL, Brown EN, Purdon PL. Broadband slow-wave modulation in posterior and anterior cortex tracks distinct states of propofol-induced unconsciousness. Sci Rep. 2020 Aug 13; 10(1):13701.
    View in: PubMed
    Score: 0.247
  8. Subramanian S, Barbieri R, Purdon PL, Brown EN. Detecting Loss and Regain of Consciousness during Propofol Anesthesia using Multimodal Indices of Autonomic State. Annu Int Conf IEEE Eng Med Biol Soc. 2020 07; 2020:824-827.
    View in: PubMed
    Score: 0.245
  9. Shao YR, Kahali P, Houle TT, Deng H, Colvin C, Dickerson BC, Brown EN, Purdon PL. Low Frontal Alpha Power Is Associated With the Propensity for Burst Suppression: An Electroencephalogram Phenotype for a "Vulnerable Brain". Anesth Analg. 2020 May 14.
    View in: PubMed
    Score: 0.243
  10. Lewis LD, Piantoni G, Peterfreund RA, Eskandar EN, Harrell PG, Akeju O, Aglio LS, Cash SS, Brown EN, Mukamel EA, Purdon PL. A transient cortical state with sleep-like sensory responses precedes emergence from general anesthesia in humans. Elife. 2018 08 10; 7.
    View in: PubMed
    Score: 0.215
  11. Walsh EC, Lee JM, Terzakis K, Zhou DW, Burns S, Buie TM, Firth PG, Shank ES, Houle TT, Brown EN, Purdon PL. Age-Dependent Changes in the Propofol-Induced Electroencephalogram in Children With Autism Spectrum Disorder. Front Syst Neurosci. 2018; 12:23.
    View in: PubMed
    Score: 0.213
  12. Brown EN, Purdon PL, Akeju O, An J. Using EEG markers to make inferences about anaesthetic-induced altered states of arousal. Br J Anaesth. 2018 07; 121(1):325-327.
    View in: PubMed
    Score: 0.209
  13. Chakravarty S, Nikolaeva K, Kishnan D, Flores FJ, Purdon PL, Brown EN. Pharmacodynamic modeling of propofol-induced general anesthesia in young adults. Health Innov Point Care Conf. 2017 Nov; 2017:44-47.
    View in: PubMed
    Score: 0.205
  14. Lee JM, Akeju O, Terzakis K, Pavone KJ, Deng H, Houle TT, Firth PG, Shank ES, Brown EN, Purdon PL. A Prospective Study of Age-dependent Changes in Propofol-induced Electroencephalogram Oscillations in Children. Anesthesiology. 2017 08; 127(2):293-306.
    View in: PubMed
    Score: 0.200
  15. Flores FJ, Hartnack KE, Fath AB, Kim SE, Wilson MA, Brown EN, Purdon PL. Thalamocortical synchronization during induction and emergence from propofol-induced unconsciousness. Proc Natl Acad Sci U S A. 2017 08 08; 114(32):E6660-E6668.
    View in: PubMed
    Score: 0.200
  16. Akeju O, Kim SE, Vazquez R, Rhee J, Pavone KJ, Hobbs LE, Purdon PL, Brown EN. Spatiotemporal Dynamics of Dexmedetomidine-Induced Electroencephalogram Oscillations. PLoS One. 2016; 11(10):e0163431.
    View in: PubMed
    Score: 0.189
  17. Akeju O, Song AH, Hamilos AE, Pavone KJ, Flores FJ, Brown EN, Purdon PL. Electroencephalogram signatures of ketamine anesthesia-induced unconsciousness. Clin Neurophysiol. 2016 06; 127(6):2414-22.
    View in: PubMed
    Score: 0.182
  18. Akeju O, Hamilos AE, Song AH, Pavone KJ, Purdon PL, Brown EN. GABAA circuit mechanisms are associated with ether anesthesia-induced unconsciousness. Clin Neurophysiol. 2016 Jun; 127(6):2472-81.
    View in: PubMed
    Score: 0.181
  19. Flores FJ, Ching S, Hartnack K, Fath AB, Purdon PL, Wilson MA, Brown EN. A PK-PD model of ketamine-induced high-frequency oscillations. J Neural Eng. 2015 Oct; 12(5):056006.
    View in: PubMed
    Score: 0.175
  20. Krishnaswamy P, Bonmassar G, Poulsen C, Pierce ET, Purdon PL, Brown EN. Reference-free removal of EEG-fMRI ballistocardiogram artifacts with harmonic regression. Neuroimage. 2016 Mar; 128:398-412.
    View in: PubMed
    Score: 0.173
  21. Pavone KJ, Akeju O, Sampson AL, Ling K, Purdon PL, Brown EN. Nitrous oxide-induced slow and delta oscillations. Clin Neurophysiol. 2016 Jan; 127(1):556-564.
    View in: PubMed
    Score: 0.172
  22. Westover MB, Kim SE, Ching S, Purdon PL, Brown EN. Robust control of burst suppression for medical coma. J Neural Eng. 2015 Aug; 12(4):046004.
    View in: PubMed
    Score: 0.172
  23. Westover MB, Ching S, Kumaraswamy VM, Akeju SO, Pierce E, Cash SS, Kilbride R, Brown EN, Purdon PL. The human burst suppression electroencephalogram of deep hypothermia. Clin Neurophysiol. 2015 Oct; 126(10):1901-1914.
    View in: PubMed
    Score: 0.168
  24. Ba D, Babadi B, Purdon PL, Brown EN. Robust spectrotemporal decomposition by iteratively reweighted least squares. Proc Natl Acad Sci U S A. 2014 Dec 16; 111(50):E5336-45.
    View in: PubMed
    Score: 0.166
  25. Akeju O, Loggia ML, Catana C, Pavone KJ, Vazquez R, Rhee J, Contreras Ramirez V, Chonde DB, Izquierdo-Garcia D, Arabasz G, Hsu S, Habeeb K, Hooker JM, Napadow V, Brown EN, Purdon PL. Disruption of thalamic functional connectivity is a neural correlate of dexmedetomidine-induced unconsciousness. Elife. 2014 Nov 28; 3:e04499.
    View in: PubMed
    Score: 0.166
  26. Akeju O, Pavone KJ, Westover MB, Vazquez R, Prerau MJ, Harrell PG, Hartnack KE, Rhee J, Sampson AL, Habeeb K, Gao L, Lei G, Pierce ET, Walsh JL, Brown EN, Purdon PL. A comparison of propofol- and dexmedetomidine-induced electroencephalogram dynamics using spectral and coherence analysis. Anesthesiology. 2014 Nov; 121(5):978-89.
    View in: PubMed
    Score: 0.165
  27. Akeju O, Westover MB, Pavone KJ, Sampson AL, Hartnack KE, Brown EN, Purdon PL. Effects of sevoflurane and propofol on frontal electroencephalogram power and coherence. Anesthesiology. 2014 Nov; 121(5):990-8.
    View in: PubMed
    Score: 0.165
  28. Wong KF, Smith AC, Pierce ET, Harrell PG, Walsh JL, Salazar-Gómez AF, Tavares CL, Purdon PL, Brown EN. Statistical modeling of behavioral dynamics during propofol-induced loss of consciousness. J Neurosci Methods. 2014 Apr 30; 227:65-74.
    View in: PubMed
    Score: 0.157
  29. Mukamel EA, Pirondini E, Babadi B, Wong KF, Pierce ET, Harrell PG, Walsh JL, Salazar-Gomez AF, Cash SS, Eskandar EN, Weiner VS, Brown EN, Purdon PL. A transition in brain state during propofol-induced unconsciousness. J Neurosci. 2014 Jan 15; 34(3):839-45.
    View in: PubMed
    Score: 0.156
  30. Babadi B, Ba D, Purdon PL, Brown EN. Convergence and Stability of a Class of Iteratively Re-weighted Least Squares Algorithms for Sparse Signal Recovery in the Presence of Noise. IEEE Trans Signal Process. 2013 Oct 30; 62(1):183-195.
    View in: PubMed
    Score: 0.154
  31. Ching S, Liberman MY, Chemali JJ, Westover MB, Kenny JD, Solt K, Purdon PL, Brown EN. Real-time closed-loop control in a rodent model of medically induced coma using burst suppression. Anesthesiology. 2013 Oct; 119(4):848-60.
    View in: PubMed
    Score: 0.153
  32. Babadi B, Obregon-Henao G, Lamus C, Hämäläinen MS, Brown EN, Purdon PL. A Subspace Pursuit-based Iterative Greedy Hierarchical solution to the neuromagnetic inverse problem. Neuroimage. 2014 Feb 15; 87:427-43.
    View in: PubMed
    Score: 0.153
  33. Chemali J, Ching S, Purdon PL, Solt K, Brown EN. Burst suppression probability algorithms: state-space methods for tracking EEG burst suppression. J Neural Eng. 2013 Oct; 10(5):056017.
    View in: PubMed
    Score: 0.153
  34. Lewis LD, Ching S, Weiner VS, Peterfreund RA, Eskandar EN, Cash SS, Brown EN, Purdon PL. Local cortical dynamics of burst suppression in the anaesthetized brain. Brain. 2013 Sep; 136(Pt 9):2727-37.
    View in: PubMed
    Score: 0.151
  35. Brandon Westover M, Shafi MM, Ching S, Chemali JJ, Purdon PL, Cash SS, Brown EN. Real-time segmentation of burst suppression patterns in critical care EEG monitoring. J Neurosci Methods. 2013 Sep 30; 219(1):131-41.
    View in: PubMed
    Score: 0.151
  36. Krishnaswamy P, Bonmassar G, Purdon PL, Brown EN. Reference-free harmonic regression technique to remove EEG-fMRI ballistocardiogram artifacts. Annu Int Conf IEEE Eng Med Biol Soc. 2013; 2013:5426-9.
    View in: PubMed
    Score: 0.146
  37. Lewis LD, Weiner VS, Mukamel EA, Donoghue JA, Eskandar EN, Madsen JR, Anderson WS, Hochberg LR, Cash SS, Brown EN, Purdon PL. Rapid fragmentation of neuronal networks at the onset of propofol-induced unconsciousness. Proc Natl Acad Sci U S A. 2012 Dec 04; 109(49):E3377-86.
    View in: PubMed
    Score: 0.144
  38. Ching S, Purdon PL, Vijayan S, Kopell NJ, Brown EN. A neurophysiological-metabolic model for burst suppression. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):3095-100.
    View in: PubMed
    Score: 0.137
  39. Lamus C, Hämäläinen MS, Temereanca S, Brown EN, Purdon PL. A spatiotemporal dynamic distributed solution to the MEG inverse problem. Neuroimage. 2012 Nov 01; 63(2):894-909.
    View in: PubMed
    Score: 0.135
  40. Long CJ, Purdon PL, Temereanca S, Desai NU, Hämäläinen MS, Brown EN. STATE-SPACE SOLUTIONS TO THE DYNAMIC MAGNETOENCEPHALOGRAPHY INVERSE PROBLEM USING HIGH PERFORMANCE COMPUTING. Ann Appl Stat. 2011 Jun 01; 5(2B):1207-1228.
    View in: PubMed
    Score: 0.130
  41. Cimenser A, Purdon PL, Pierce ET, Walsh JL, Salazar-Gomez AF, Harrell PG, Tavares-Stoeckel C, Habeeb K, Brown EN. Tracking brain states under general anesthesia by using global coherence analysis. Proc Natl Acad Sci U S A. 2011 May 24; 108(21):8832-7.
    View in: PubMed
    Score: 0.130
  42. Brown EN, Purdon PL, Van Dort CJ. General anesthesia and altered states of arousal: a systems neuroscience analysis. Annu Rev Neurosci. 2011; 34:601-28.
    View in: PubMed
    Score: 0.127
  43. Mukamel EA, Wong KF, Prerau MJ, Brown EN, Purdon PL. Phase-based measures of cross-frequency coupling in brain electrical dynamics under general anesthesia. Annu Int Conf IEEE Eng Med Biol Soc. 2011; 2011:1981-4.
    View in: PubMed
    Score: 0.127
  44. Wong KF, Smith AC, Pierce ET, Harrell PG, Walsh JL, Salazar AF, Tavares CL, Cimenser A, Prerau MJ, Mukamel EA, Sampson A, Purdon PL, Brown EN. Bayesian analysis of trinomial data in behavioral experiments and its application to human studies of general anesthesia. Annu Int Conf IEEE Eng Med Biol Soc. 2011; 2011:4705-8.
    View in: PubMed
    Score: 0.127
  45. Wong KF, Mukamel EA, Salazar AF, Pierce ET, Harrell PG, Walsh JL, Sampson A, Brown EN, Purdon PL. Robust time-varying multivariate coherence estimation: application to electroencephalogram recordings during general anesthesia. Annu Int Conf IEEE Eng Med Biol Soc. 2011; 2011:4725-8.
    View in: PubMed
    Score: 0.127
  46. An J, Jonnalagadda D, Moura V, Purdon PL, Brown EN, Westover MB. Variability in pharmacologically-induced coma for treatment of refractory status epilepticus. PLoS One. 2018; 13(10):e0205789.
    View in: PubMed
    Score: 0.055
  47. Soplata AE, McCarthy MM, Sherfey J, Lee S, Purdon PL, Brown EN, Kopell N. Thalamocortical control of propofol phase-amplitude coupling. PLoS Comput Biol. 2017 12; 13(12):e1005879.
    View in: PubMed
    Score: 0.051
  48. Purdon PL, Solt K, Sims NM, Brown EN, Westover MB. Design, implementation, and evaluation of a physiological closed-loop control device for medically-induced coma. Annu Int Conf IEEE Eng Med Biol Soc. 2017 Jul; 2017:4313-4316.
    View in: PubMed
    Score: 0.050
  49. Pavone KJ, Su L, Gao L, Eromo E, Vazquez R, Rhee J, Hobbs LE, Ibala R, Demircioglu G, Purdon PL, Brown EN, Akeju O. Lack of Responsiveness during the Onset and Offset of Sevoflurane Anesthesia Is Associated with Decreased Awake-Alpha Oscillation Power. Front Syst Neurosci. 2017; 11:38.
    View in: PubMed
    Score: 0.049
  50. Miran S, Purdon PL, Brown EN, Babadi B. Robust Estimation of Sparse Narrowband Spectra from Neuronal Spiking Data. IEEE Trans Biomed Eng. 2017 10; 64(10):2462-2474.
    View in: PubMed
    Score: 0.048
  51. Cornelissen L, Kim SE, Purdon PL, Brown EN, Berde CB. Age-dependent electroencephalogram (EEG) patterns during sevoflurane general anesthesia in infants. Elife. 2015 Jun 23; 4:e06513.
    View in: PubMed
    Score: 0.043
  52. Ghassemi MM, Amorim E, Pati SB, Mark RG, Brown EN, Purdon PL, Westover MB. An enhanced cerebral recovery index for coma prognostication following cardiac arrest. Annu Int Conf IEEE Eng Med Biol Soc. 2015; 2015:534-7.
    View in: PubMed
    Score: 0.042
  53. An J, Jonnalagadda D, Moura V, Purdon PL, Brown EN, Westover MB. Spatial variation in automated burst suppression detection in pharmacologically induced coma. Annu Int Conf IEEE Eng Med Biol Soc. 2015; 2015:7430-3.
    View in: PubMed
    Score: 0.042
  54. Vijayan S, Ching S, Purdon PL, Brown EN, Kopell NJ. Thalamocortical mechanisms for the anteriorization of a rhythms during propofol-induced unconsciousness. J Neurosci. 2013 Jul 03; 33(27):11070-5.
    View in: PubMed
    Score: 0.038
  55. Vijayan S, Ching S, Purdon PL, Brown EN, Kopell NJ. Biophysical Modeling of Alpha Rhythms During Halothane-Induced Unconsciousness. Int IEEE EMBS Conf Neural Eng. 2013; 1104-1107.
    View in: PubMed
    Score: 0.036
  56. Chen Z, Purdon PL, Brown EN, Barbieri R. A unified point process probabilistic framework to assess heartbeat dynamics and autonomic cardiovascular control. Front Physiol. 2012; 3:4.
    View in: PubMed
    Score: 0.034
  57. Citi L, Valenza G, Purdon PL, Brown EN, Barbieri R. Monitoring heartbeat nonlinear dynamics during general anesthesia by using the instantaneous dominant Lyapunov exponent. Annu Int Conf IEEE Eng Med Biol Soc. 2012; 2012:3124-7.
    View in: PubMed
    Score: 0.034
  58. Chen Z, Citi L, Purdon PL, Brown EN, Barbieri R. Instantaneous assessment of autonomic cardiovascular control during general anesthesia. Annu Int Conf IEEE Eng Med Biol Soc. 2011; 2011:8444-7.
    View in: PubMed
    Score: 0.032
  59. Ching S, Cimenser A, Purdon PL, Brown EN, Kopell NJ. Thalamocortical model for a propofol-induced alpha-rhythm associated with loss of consciousness. Proc Natl Acad Sci U S A. 2010 Dec 28; 107(52):22665-70.
    View in: PubMed
    Score: 0.032
  60. Chen Z, Purdon PL, Harrell G, Pierce ET, Walsh J, Brown EN, Barbieri R. Dynamic assessment of baroreflex control of heart rate during induction of propofol anesthesia using a point process method. Ann Biomed Eng. 2011 Jan; 39(1):260-76.
    View in: PubMed
    Score: 0.031
  61. Chen Z, Purdon PL, Brown EN, Barbieri R. A differential autoregressive modeling approach within a point process framework for non-stationary heartbeat intervals analysis. Annu Int Conf IEEE Eng Med Biol Soc. 2010; 2010:3567-70.
    View in: PubMed
    Score: 0.030
  62. Chen Z, Purdon PL, Pierce ET, Harrell G, Walsh J, Salazar AF, Tavares CL, Brown EN, Barbieri R. Linear and nonlinear quantification of respiratory sinus arrhythmia during propofol general anesthesia. Annu Int Conf IEEE Eng Med Biol Soc. 2009; 2009:5336-9.
    View in: PubMed
    Score: 0.028
  63. Bonmassar G, Purdon PL, Jääskeläinen IP, Chiappa K, Solo V, Brown EN, Belliveau JW. Motion and ballistocardiogram artifact removal for interleaved recording of EEG and EPs during MRI. Neuroimage. 2002 Aug; 16(4):1127-41.
    View in: PubMed
    Score: 0.018
Connection Strength
The connection strength for co-authors is the sum of the scores for each of their shared publications.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.