Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Emery Neal Brown, Ph.D., M.D.

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Department
Address
Phone
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Mentoring
Age-Dependent Effects of Propofol on Frontal Electroencephalogram Power
Summer, 06/05/14 - 08/22/14

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01MH115592 (MILLER, EARL K) Sep 8, 2017 - May 31, 2022
    NIH/NIMH
    Thalamocortical Dynamics and Consciousness
    Role: Co-Principal Investigator
  2. R01AG056015 (PURDON, PATRICK L.) Apr 15, 2017 - Mar 31, 2022
    NIH/NIA
    The Aging Brain Under General Anesthesia: Neurophysiology, Neuroimaging Biomarkers of Aging and Alzheimer's Disease, and Post-Operative Cognitive Outcomes
    Role: Co-Principal Investigator
  3. P01GM118269 (BROWN, EMERY N.) Feb 10, 2017 - Jan 31, 2022
    NIH/NIGMS
    Integrated Systems Neuroscience Studies of Anaesthesia
    Role: Principal Investigator
  4. R01EB022726 (BROWN, EMERY N.) Sep 30, 2016 - Jun 30, 2019
    NIH/NIBIB
    Filtered Point Process Inference Framework for Modeling Neural Data
    Role: Principal Investigator
  5. U01FD005935 (COOPER, THOMAS) Sep 15, 2016 - Aug 31, 2021
    FDA
    A Public-Private Partnership to support the investigation of anesthesia-related neurotoxicity in the pediatric population through non-clinical and clinical studies.
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Yang Y, Lee J, Guidera J, Vlasov K, Pei J, Brown EN, Solt K, Shanechi MM. Developing a personalized closed-loop controller of medically-induced coma in a rodent model. J Neural Eng. 2019 Mar 11. PMID: 30856619.
    Citations:    
  2. Martorell AJ, Paulson AL, Suk HJ, Abdurrob F, Drummond GT, Guan W, Young JZ, Kim DN, Kritskiy O, Barker SJ, Mangena V, Prince SM, Brown EN, Chung K, Boyden ES, Singer AC, Tsai LH. Multi-sensory Gamma Stimulation Ameliorates Alzheimer's-Associated Pathology and Improves Cognition. Cell. 2019 Mar 07. PMID: 30879788.
    Citations:    
  3. Reshef ER, Schiff ND, Brown EN. A Neurologic Examination for Anesthesiologists: Assessing Arousal Level during Induction, Maintenance, and Emergence. Anesthesiology. 2019 Mar; 130(3):462-471. PMID: 30664547.
    Citations:    Fields:    
  4. MacCormick IJC, Williams BM, Zheng Y, Li K, Al-Bander B, Czanner S, Cheeseman R, Willoughby CE, Brown EN, Spaeth GL, Czanner G. Accurate, fast, data efficient and interpretable glaucoma diagnosis with automated spatial analysis of the whole cup to disc profile. PLoS One. 2019; 14(1):e0209409. PMID: 30629635.
    Citations:    Fields:    
  5. Brown EN, Pavone KJ, Naranjo M. Multimodal General Anesthesia: Theory and Practice. Anesth Analg. 2018 Nov; 127(5):1246-1258. PMID: 30252709.
    Citations:    Fields:    
  6. An J, Jonnalagadda D, Moura V, Purdon PL, Brown EN, Westover MB. Variability in pharmacologically-induced coma for treatment of refractory status epilepticus. PLoS One. 2018; 13(10):e0205789. PMID: 30379935.
    Citations:    Fields:    
  7. Iaccarino HF, Singer AC, Martorell AJ, Rudenko A, Gao F, Gillingham TZ, Mathys H, Seo J, Kritskiy O, Abdurrob F, Adaikkan C, Canter RG, Rueda R, Brown EN, Boyden ES, Tsai LH. Author Correction: Gamma frequency entrainment attenuates amyloid load and modifies microglia. Nature. 2018 10; 562(7725):E1. PMID: 30046102.
    Citations:    Fields:    
  8. Ionescu DF, Bentley KH, Eikermann M, Taylor N, Akeju O, Swee MB, Pavone KJ, Petrie SR, Dording C, Mischoulon D, Alpert JE, Brown EN, Baer L, Nock MK, Fava M, Cusin C. Repeat-dose ketamine augmentation for treatment-resistant depression with chronic suicidal ideation: A randomized, double blind, placebo controlled trial. J Affect Disord. 2019 01 15; 243:516-524. PMID: 30286416.
    Citations:    Fields:    
  9. Lewis LD, Piantoni G, Peterfreund RA, Eskandar EN, Harrell PG, Akeju O, Aglio LS, Cash SS, Brown EN, Mukamel EA, Purdon PL. A transient cortical state with sleep-like sensory responses precedes emergence from general anesthesia in humans. Elife. 2018 08 10; 7. PMID: 30095069.
    Citations:    Fields:    Translation:Humans
  10. Liu M, Shi R, Hwang H, Han KS, Wong MH, Ren X, Lewis LD, Brown EN, Xu W. SAP102 regulates synaptic AMPAR function through a CNIH-2-dependent mechanism. J Neurophysiol. 2018 Oct 01; 120(4):1578-1586. PMID: 30067114.
    Citations: 1     Fields:    
  11. Subramanian S, Barbieri R, Brown EN. A Point Process Characterization Of Electrodermal Activity. Conf Proc IEEE Eng Med Biol Soc. 2018 07; 2018:37-40. PMID: 30440335.
    Citations:    Fields:    
  12. An J, Flores FJ, Kodandaramaiah SB, Betta ID, Nikolaeva K, Boyden ES, Forest CR, Brown EN. Automated Assessment of Loss of Consciousness Using Whisker And Paw Movements During Anesthetic Dosing in Head-Fixed Rodents. Conf Proc IEEE Eng Med Biol Soc. 2018 Jul; 2018:730-733. PMID: 30440500.
    Citations:    Fields:    
  13. Song AH, Chakravarty S, Brown EN. A Smoother State Space Multitaper Spectrogram. Conf Proc IEEE Eng Med Biol Soc. 2018 07; 2018:33-36. PMID: 30440334.
    Citations:    Fields:    
  14. Walsh EC, Lee JM, Terzakis K, Zhou DW, Burns S, Buie TM, Firth PG, Shank ES, Houle TT, Brown EN, Purdon PL. Age-Dependent Changes in the Propofol-Induced Electroencephalogram in Children With Autism Spectrum Disorder. Front Syst Neurosci. 2018; 12:23. PMID: 29988455.
    Citations:    
  15. Chang YC, Khan S, Taulu S, Kuperberg G, Brown EN, Hämäläinen MS, Temereanca S. Left-Lateralized Contributions of Saccades to Cortical Activity During a One-Back Word Recognition Task. Front Neural Circuits. 2018; 12:38. PMID: 29867372.
    Citations:    Fields:    
  16. Allsop SA, Wichmann R, Mills F, Burgos-Robles A, Chang CJ, Felix-Ortiz AC, Vienne A, Beyeler A, Izadmehr EM, Glober G, Cum MI, Stergiadou J, Anandalingam KK, Farris K, Namburi P, Leppla CA, Weddington JC, Nieh EH, Smith AC, Ba D, Brown EN, Tye KM. Corticoamygdala Transfer of Socially Derived Information Gates Observational Learning. Cell. 2018 05 31; 173(6):1329-1342.e18. PMID: 29731170.
    Citations:    Fields:    
  17. Shelton KT, Qu J, Bilotta F, Brown EN, Cudemus G, D'Alessandro DA, Deng H, DiBiasio A, Gitlin JA, Hahm EY, Hobbs LE, Houle TT, Ibala R, Loggia ML, Pavone KJ, Shaefi S, Tolis G, Westover MB, Akeju O. Minimizing ICU Neurological Dysfunction with Dexmedetomidine-induced Sleep (MINDDS): protocol for a randomised, double-blind, parallel-arm, placebo-controlled trial. BMJ Open. 2018 04 20; 8(4):e020316. PMID: 29678977.
    Citations: 1     Fields:    Translation:Humans
  18. Brown EN, Purdon PL, Akeju O, An J. Using EEG markers to make inferences about anaesthetic-induced altered states of arousal. Br J Anaesth. 2018 07; 121(1):325-327. PMID: 29935587.
    Citations:    Fields:    
  19. Kodandaramaiah SB, Flores FJ, Holst GL, Singer AC, Han X, Brown EN, Boyden ES, Forest CR. Multi-neuron intracellular recording in vivo via interacting autopatching robots. Elife. 2018 Jan 03; 7. PMID: 29297466.
    Citations:    Fields:    
  20. Kim SE, Behr MK, Ba D, Brown EN. State-space multitaper time-frequency analysis. Proc Natl Acad Sci U S A. 2018 01 02; 115(1):E5-E14. PMID: 29255032.
    Citations: 2     Fields:    Translation:Humans
  21. Soplata AE, McCarthy MM, Sherfey J, Lee S, Purdon PL, Brown EN, Kopell N. Thalamocortical control of propofol phase-amplitude coupling. PLoS Comput Biol. 2017 12; 13(12):e1005879. PMID: 29227992.
    Citations:    Fields:    Translation:Humans
  22. Akeju O, Hobbs LE, Gao L, Burns SM, Pavone KJ, Plummer GS, Walsh EC, Houle TT, Kim SE, Bianchi MT, Ellenbogen JM, Brown EN. Dexmedetomidine promotes biomimetic non-rapid eye movement stage 3 sleep in humans: A pilot study. Clin Neurophysiol. 2018 01; 129(1):69-78. PMID: 29154132.
    Citations:    Fields:    Translation:Humans
  23. Lee JM, Akeju O, Terzakis K, Pavone KJ, Deng H, Houle TT, Firth PG, Shank ES, Brown EN, Purdon PL. A Prospective Study of Age-dependent Changes in Propofol-induced Electroencephalogram Oscillations in Children. Anesthesiology. 2017 08; 127(2):293-306. PMID: 28657957.
    Citations: 2     Fields:    Translation:Humans
  24. Flores FJ, Hartnack KE, Fath AB, Kim SE, Wilson MA, Brown EN, Purdon PL. Thalamocortical synchronization during induction and emergence from propofol-induced unconsciousness. Proc Natl Acad Sci U S A. 2017 08 08; 114(32):E6660-E6668. PMID: 28743752.
    Citations: 6     Fields:    Translation:Animals
  25. Guidera JA, Taylor NE, Lee JT, Vlasov KY, Pei J, Stephen EP, Mayo JP, Brown EN, Solt K. Sevoflurane Induces Coherent Slow-Delta Oscillations in Rats. Front Neural Circuits. 2017; 11:36. PMID: 28725184.
    Citations: 2     Fields:    Translation:Animals
  26. Faghih RT, Styer AK, Brown EN. Automated ovarian follicular monitoring: A novel real-time approach. Conf Proc IEEE Eng Med Biol Soc. 2017 07; 2017:632-635. PMID: 29059952.
    Citations:    Fields:    Translation:Humans
  27. Purdon PL, Solt K, Sims NM, Brown EN, Westover MB. Design, implementation, and evaluation of a physiological closed-loop control device for medically-induced coma. Conf Proc IEEE Eng Med Biol Soc. 2017 07; 2017:4313-4316. PMID: 29060851.
    Citations:    Fields:    Translation:Humans
  28. Song AH, Kucyi A, Napadow V, Brown EN, Loggia ML, Akeju O. Pharmacological Modulation of Noradrenergic Arousal Circuitry Disrupts Functional Connectivity of the Locus Ceruleus in Humans. J Neurosci. 2017 07 19; 37(29):6938-6945. PMID: 28626012.
    Citations: 4     Fields:    Translation:HumansCellsCTClinical Trials
  29. Pavone KJ, Su L, Gao L, Eromo E, Vazquez R, Rhee J, Hobbs LE, Ibala R, Demircioglu G, Purdon PL, Brown EN, Akeju O. Lack of Responsiveness during the Onset and Offset of Sevoflurane Anesthesia Is Associated with Decreased Awake-Alpha Oscillation Power. Front Syst Neurosci. 2017; 11:38. PMID: 28611601.
    Citations: 2     
  30. Akeju O, Brown EN. Neural oscillations demonstrate that general anesthesia and sedative states are neurophysiologically distinct from sleep. Curr Opin Neurobiol. 2017 06; 44:178-185. PMID: 28544930.
    Citations: 2     Fields:    Translation:HumansCells
  31. Bianciardi M, Strong C, Toschi N, Edlow BL, Fischl B, Brown EN, Rosen BR, Wald LL. A probabilistic template of human mesopontine tegmental nuclei from in vivo 7T MRI. Neuroimage. 2018 04 15; 170:222-230. PMID: 28476663.
    Citations:    Fields:    Translation:Humans
  32. Brown EN, Behrmann M. Controversy in statistical analysis of functional magnetic resonance imaging data. Proc Natl Acad Sci U S A. 2017 04 25; 114(17):E3368-E3369. PMID: 28420797.
    Citations: 4     Fields:    Translation:Humans
  33. Hashmi JA, Loggia ML, Khan S, Gao L, Kim J, Napadow V, Brown EN, Akeju O. Dexmedetomidine Disrupts the Local and Global Efficiencies of Large-scale Brain Networks. Anesthesiology. 2017 Mar; 126(3):419-430. PMID: 28092321.
    Citations: 3     Fields:    Translation:Humans
  34. Cusin C, Ionescu DF, Pavone KJ, Akeju O, Cassano P, Taylor N, Eikermann M, Durham K, Swee MB, Chang T, Dording C, Soskin D, Kelley J, Mischoulon D, Brown EN, Fava M. Ketamine augmentation for outpatients with treatment-resistant depression: Preliminary evidence for two-step intravenous dose escalation. Aust N Z J Psychiatry. 2017 Jan; 51(1):55-64. PMID: 26893373.
    Citations: 6     Fields:    Translation:Humans
  35. Miran S, Purdon PL, Brown EN, Babadi B. Robust Estimation of Sparse Narrowband Spectra from Neuronal Spiking Data. IEEE Trans Biomed Eng. 2017 10; 64(10):2462-2474. PMID: 28026746.
    Citations:    Fields:    Translation:HumansCells
  36. Iaccarino HF, Singer AC, Martorell AJ, Rudenko A, Gao F, Gillingham TZ, Mathys H, Seo J, Kritskiy O, Abdurrob F, Adaikkan C, Canter RG, Rueda R, Brown EN, Boyden ES, Tsai LH. Gamma frequency entrainment attenuates amyloid load and modifies microglia. Nature. 2016 12 07; 540(7632):230-235. PMID: 27929004.
    Citations: 38     Fields:    Translation:AnimalsCells
  37. Kenny JD, Chemali JJ, Cotten JF, Van Dort CJ, Kim SE, Ba D, Taylor NE, Brown EN, Solt K. Physostigmine and Methylphenidate Induce Distinct Arousal States During Isoflurane General Anesthesia in Rats. Anesth Analg. 2016 11; 123(5):1210-1219. PMID: 26991753.
    Citations: 1     Fields:    Translation:Animals
  38. Lee MA, Bakh N, Bisker G, Brown EN, Strano MS. A Pharmacokinetic Model of a Tissue Implantable Cortisol Sensor. Adv Healthc Mater. 2016 12; 5(23):3004-3015. PMID: 27782371.
    Citations:    Fields:    Translation:Humans
  39. Taylor NE, Van Dort CJ, Kenny JD, Pei J, Guidera JA, Vlasov KY, Lee JT, Boyden ES, Brown EN, Solt K. Optogenetic activation of dopamine neurons in the ventral tegmental area induces reanimation from general anesthesia. Proc Natl Acad Sci U S A. 2016 Nov 08; 113(45):12826-12831. PMID: 27791160.
    Citations: 11     Fields:    
  40. Akeju O, Kim SE, Vazquez R, Rhee J, Pavone KJ, Hobbs LE, Purdon PL, Brown EN. Spatiotemporal Dynamics of Dexmedetomidine-Induced Electroencephalogram Oscillations. PLoS One. 2016; 11(10):e0163431. PMID: 27711165.
    Citations: 7     Fields:    Translation:HumansCTClinical Trials
  41. Ishizawa Y, Ahmed OJ, Patel SR, Gale JT, Sierra-Mercado D, Brown EN, Eskandar EN. Dynamics of Propofol-Induced Loss of Consciousness Across Primate Neocortex. J Neurosci. 2016 07 20; 36(29):7718-26. PMID: 27445148; PMCID: PMC4951576.
    Citations: 8     Fields:    Translation:Animals
  42. Ionescu DF, Swee MB, Pavone KJ, Taylor N, Akeju O, Baer L, Nyer M, Cassano P, Mischoulon D, Alpert JE, Brown EN, Nock MK, Fava M, Cusin C. Rapid and Sustained Reductions in Current Suicidal Ideation Following Repeated Doses of Intravenous Ketamine: Secondary Analysis of an Open-Label Study. J Clin Psychiatry. 2016 06; 77(6):e719-25. PMID: 27232360.
    Citations: 9     Fields:    Translation:Humans
  43. Bianciardi M, Toschi N, Eichner C, Polimeni JR, Setsompop K, Brown EN, Hämäläinen MS, Rosen BR, Wald LL. In vivo functional connectome of human brainstem nuclei of the ascending arousal, autonomic, and motor systems by high spatial resolution 7-Tesla fMRI. MAGMA. 2016 Jun; 29(3):451-62. PMID: 27126248; PMCID: PMC4892960.
    Citations: 6     Fields:    Translation:HumansCells
  44. Akeju O, Song AH, Hamilos AE, Pavone KJ, Flores FJ, Brown EN, Purdon PL. Electroencephalogram signatures of ketamine anesthesia-induced unconsciousness. Clin Neurophysiol. 2016 06; 127(6):2414-22. PMID: 27178861; PMCID: PMC4871620.
    Citations: 10     Fields:    Translation:Humans
  45. Muindi F, Kenny JD, Taylor NE, Solt K, Wilson MA, Brown EN, Van Dort CJ. Electrical stimulation of the parabrachial nucleus induces reanimation from isoflurane general anesthesia. Behav Brain Res. 2016 06 01; 306:20-5. PMID: 26971629.
    Citations:    Fields:    Translation:Animals
  46. Akeju O, Hamilos AE, Song AH, Pavone KJ, Purdon PL, Brown EN. GABAA circuit mechanisms are associated with ether anesthesia-induced unconsciousness. Clin Neurophysiol. 2016 Jun; 127(6):2472-81. PMID: 27178867; PMCID: PMC4869993.
    Citations: 4     Fields:    Translation:Humans
  47. Lewis LD, Voigts J, Flores FJ, Schmitt LI, Wilson MA, Halassa MM, Brown EN. Thalamic reticular nucleus induces fast and local modulation of arousal state. Elife. 2015 Oct 13; 4:e08760. PMID: 26460547; PMCID: PMC4686423.
    Citations: 24     Fields:    Translation:Animals
  48. Purdon PL, Sampson A, Pavone KJ, Brown EN. Clinical Electroencephalography for Anesthesiologists: Part I: Background and Basic Signatures. Anesthesiology. 2015 Oct; 123(4):937-60. PMID: 26275092; PMCID: PMC4573341.
    Citations: 44     Fields:    Translation:Humans
  49. Purdon PL, Zhou DW, Akeju O, Brown EN. In reply. Anesthesiology. 2015 Sep; 123(3):725-8. PMID: 26284863.
    Citations:    Fields:    Translation:Humans
  50. Flores FJ, Ching S, Hartnack K, Fath AB, Purdon PL, Wilson MA, Brown EN. A PK-PD model of ketamine-induced high-frequency oscillations. J Neural Eng. 2015 Oct; 12(5):056006. PMID: 26268223.
    Citations:    Fields:    Translation:Animals
  51. Bianciardi M, Toschi N, Edlow BL, Eichner C, Setsompop K, Polimeni JR, Brown EN, Kinney HC, Rosen BR, Wald LL. Toward an In Vivo Neuroimaging Template of Human Brainstem Nuclei of the Ascending Arousal, Autonomic, and Motor Systems. Brain Connect. 2015 Dec; 5(10):597-607. PMID: 26066023; PMCID: PMC4684653.
    Citations: 7     Fields:    Translation:Humans
  52. Faghih RT, Dahleh MA, Brown EN. An optimization formulation for characterization of pulsatile cortisol secretion. Front Neurosci. 2015; 9:228. PMID: 26321898; PMCID: PMC4531247.
    Citations:    
  53. Faghih RT, Stokes PA, Marin MF, Zsido RG, Zorowitz S, Rosenbaum BL, Milad MR, Dougherty DD, Eskandar EN, Widge AS, Brown EN, Barbieri R. Characterization of fear conditioning and fear extinction by analysis of electrodermal activity. Conf Proc IEEE Eng Med Biol Soc. 2015 Aug; 2015:7814-8. PMID: 26738104.
    Citations:    Fields:    Translation:Humans
  54. Kenny JD, Taylor NE, Brown EN, Solt K. Dextroamphetamine (but Not Atomoxetine) Induces Reanimation from General Anesthesia: Implications for the Roles of Dopamine and Norepinephrine in Active Emergence. PLoS One. 2015; 10(7):e0131914. PMID: 26148114; PMCID: PMC4492624.
    Citations: 8     Fields:    Translation:Animals
  55. Krishnaswamy P, Bonmassar G, Poulsen C, Pierce ET, Purdon PL, Brown EN. Reference-free removal of EEG-fMRI ballistocardiogram artifacts with harmonic regression. Neuroimage. 2016 Mar; 128:398-412. PMID: 26151100; PMCID: PMC4761527.
    Citations: 3     Fields:    Translation:Humans
  56. Purdon PL, Pavone KJ, Akeju O, Smith AC, Sampson AL, Lee J, Zhou DW, Solt K, Brown EN. The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia. Br J Anaesth. 2015 Jul; 115 Suppl 1:i46-i57. PMID: 26174300.
    Citations: 14     Fields:    Translation:Humans
  57. Van Dort CJ, Brown EN. Reply to Grace: Role of cholinergic neurons in rapid eye movement (REM) sleep control. Proc Natl Acad Sci U S A. 2015 Jul 21; 112(29):E3756. PMID: 26124152; PMCID: PMC4517216.
    Citations: 1     Fields:    Translation:AnimalsCells
  58. Cornelissen L, Kim SE, Purdon PL, Brown EN, Berde CB. Age-dependent electroencephalogram (EEG) patterns during sevoflurane general anesthesia in infants. Elife. 2015 Jun 23; 4:e06513. PMID: 26102526; PMCID: PMC4502759.
    Citations: 8     Fields:    Translation:Humans
  59. Pavone KJ, Akeju O, Sampson AL, Ling K, Purdon PL, Brown EN. Nitrous oxide-induced slow and delta oscillations. Clin Neurophysiol. 2016 Jan; 127(1):556-564. PMID: 26118489; PMCID: PMC4675698.
    Citations: 9     Fields:    Translation:Humans
  60. Westover MB, Kim SE, Ching S, Purdon PL, Brown EN. Robust control of burst suppression for medical coma. J Neural Eng. 2015 Aug; 12(4):046004. PMID: 26020243; PMCID: PMC4517835.
    Citations: 2     Fields:    Translation:Humans
  61. Czanner G, Sarma SV, Ba D, Eden UT, Wu W, Eskandar E, Lim HH, Temereanca S, Suzuki WA, Brown EN. Measuring the signal-to-noise ratio of a neuron. Proc Natl Acad Sci U S A. 2015 Jun 09; 112(23):7141-6. PMID: 25995363; PMCID: PMC4466709.
    Citations: 5     Fields:    Translation:AnimalsCells
  62. Jorgenson LA, Newsome WT, Anderson DJ, Bargmann CI, Brown EN, Deisseroth K, Donoghue JP, Hudson KL, Ling GS, MacLeish PR, Marder E, Normann RA, Sanes JR, Schnitzer MJ, Sejnowski TJ, Tank DW, Tsien RY, Ugurbil K, Wingfield JC. The BRAIN Initiative: developing technology to catalyse neuroscience discovery. Philos Trans R Soc Lond B Biol Sci. 2015 May 19; 370(1668). PMID: 25823863.
    Citations: 31     Fields:    Translation:Humans
  63. Faghih RT, Dahleh MA, Adler GK, Klerman EB, Brown EN. Quantifying Pituitary-Adrenal Dynamics and Deconvolution of Concurrent Cortisol and Adrenocorticotropic Hormone Data by Compressed Sensing. IEEE Trans Biomed Eng. 2015 Oct; 62(10):2379-88. PMID: 25935025; PMCID: PMC4579049.
    Citations: 1     Fields:    Translation:Humans
  64. Song W, Cajigas I, Brown EN, Giszter SF. Adaptation to elastic loads and BMI robot controls during rat locomotion examined with point-process GLMs. Front Syst Neurosci. 2015; 9:62. PMID: 25972789; PMCID: PMC4411868.
    Citations:    
  65. Westover MB, Ching S, Kumaraswamy VM, Akeju SO, Pierce E, Cash SS, Kilbride R, Brown EN, Purdon PL. The human burst suppression electroencephalogram of deep hypothermia. Clin Neurophysiol. 2015 Oct; 126(10):1901-1914. PMID: 25649968.
    Citations: 3     Fields:    Translation:Humans
  66. An J, Jonnalagadda D, Moura V, Purdon PL, Brown EN, Westover MB. Spatial variation in automated burst suppression detection in pharmacologically induced coma. Conf Proc IEEE Eng Med Biol Soc. 2015; 2015:7430-3. PMID: 26738009; PMCID: PMC4876722.
    Citations: 2     Fields:    Translation:Humans
  67. Faghih RT, Barbieri R, Paulk AC, Asaad WF, Brown EN, Dougherty DD, Widge AS, Eskandar EN, Eden UT. Estimating a dynamic state to relate neural spiking activity to behavioral signals during cognitive tasks. Conf Proc IEEE Eng Med Biol Soc. 2015; 2015:7808-13. PMID: 26738103.
    Citations: 1     Fields:    Translation:HumansAnimals
  68. Ghassemi MM, Amorim E, Pati SB, Mark RG, Brown EN, Purdon PL, Westover MB. An enhanced cerebral recovery index for coma prognostication following cardiac arrest. Conf Proc IEEE Eng Med Biol Soc. 2015; 2015:534-7. PMID: 26736317.
    Citations: 1     Fields:    Translation:Humans
  69. Van Dort CJ, Zachs DP, Kenny JD, Zheng S, Goldblum RR, Gelwan NA, Ramos DM, Nolan MA, Wang K, Weng FJ, Lin Y, Wilson MA, Brown EN. Optogenetic activation of cholinergic neurons in the PPT or LDT induces REM sleep. Proc Natl Acad Sci U S A. 2015 Jan 13; 112(2):584-9. PMID: 25548191; PMCID: PMC4299243.
    Citations: 40     Fields:    Translation:AnimalsCells
  70. Kenny JD, Westover MB, Ching S, Brown EN, Solt K. Propofol and sevoflurane induce distinct burst suppression patterns in rats. Front Syst Neurosci. 2014; 8:237. PMID: 25565990; PMCID: PMC4270179.
    Citations: 10     
  71. Ba D, Babadi B, Purdon PL, Brown EN. Robust spectrotemporal decomposition by iteratively reweighted least squares. Proc Natl Acad Sci U S A. 2014 Dec 16; 111(50):E5336-45. PMID: 25468968; PMCID: PMC4273341.
    Citations: 4     Fields:    Translation:Humans
  72. Akeju O, Loggia ML, Catana C, Pavone KJ, Vazquez R, Rhee J, Contreras Ramirez V, Chonde DB, Izquierdo-Garcia D, Arabasz G, Hsu S, Habeeb K, Hooker JM, Napadow V, Brown EN, Purdon PL. Disruption of thalamic functional connectivity is a neural correlate of dexmedetomidine-induced unconsciousness. Elife. 2014 Nov 28; 3:e04499. PMID: 25432022; PMCID: PMC4280551.
    Citations: 26     Fields:    Translation:Humans
  73. Akeju O, Pavone KJ, Westover MB, Vazquez R, Prerau MJ, Harrell PG, Hartnack KE, Rhee J, Sampson AL, Habeeb K, Gao L, Lei G, Pierce ET, Walsh JL, Brown EN, Purdon PL. A comparison of propofol- and dexmedetomidine-induced electroencephalogram dynamics using spectral and coherence analysis. Anesthesiology. 2014 Nov; 121(5):978-89. PMID: 25187999; PMCID: PMC4304638.
    Citations: 26     Fields:    Translation:Humans
  74. Akeju O, Westover MB, Pavone KJ, Sampson AL, Hartnack KE, Brown EN, Purdon PL. Effects of sevoflurane and propofol on frontal electroencephalogram power and coherence. Anesthesiology. 2014 Nov; 121(5):990-8. PMID: 25233374; PMCID: PMC4206606.
    Citations: 32     Fields:    Translation:Humans
  75. Malik WQ, Hochberg LR, Donoghue JP, Brown EN. Modulation depth estimation and variable selection in state-space models for neural interfaces. IEEE Trans Biomed Eng. 2015 Feb; 62(2):570-81. PMID: 25265627.
    Citations: 4     Fields:    Translation:HumansCells
  76. Halassa MM, Chen Z, Wimmer RD, Brunetti PM, Zhao S, Zikopoulos B, Wang F, Brown EN, Wilson MA. State-dependent architecture of thalamic reticular subnetworks. Cell. 2014 Aug 14; 158(4):808-821. PMID: 25126786; PMCID: PMC4205482.
    Citations: 51     Fields:    Translation:Animals
  77. Solt K, Van Dort CJ, Chemali JJ, Taylor NE, Kenny JD, Brown EN. Electrical stimulation of the ventral tegmental area induces reanimation from general anesthesia. Anesthesiology. 2014 Aug; 121(2):311-9. PMID: 24398816; PMCID: PMC4112744.
    Citations: 19     Fields:    Translation:Animals
  78. Wu W, Chen Z, Gao X, Li Y, Brown EN, Gao S. Probabilistic Common Spatial Patterns for Multichannel EEG Analysis. IEEE Trans Pattern Anal Mach Intell. 2015 Mar; 37(3):639-53. PMID: 26005228; PMCID: PMC4441303.
    Citations: 3     Fields:    Translation:Humans
  79. Babadi B, Brown EN. A review of multitaper spectral analysis. IEEE Trans Biomed Eng. 2014 May; 61(5):1555-64. PMID: 24759284.
    Citations: 28     Fields:    Translation:Humans
  80. Wong KF, Smith AC, Pierce ET, Harrell PG, Walsh JL, Salazar-Gómez AF, Tavares CL, Purdon PL, Brown EN. Statistical modeling of behavioral dynamics during propofol-induced loss of consciousness. J Neurosci Methods. 2014 Apr 30; 227:65-74. PMID: 24530701; PMCID: PMC4304648.
    Citations: 2     Fields:    Translation:Humans
  81. Ba D, Temereanca S, Brown EN. Algorithms for the analysis of ensemble neural spiking activity using simultaneous-event multivariate point-process models. Front Comput Neurosci. 2014; 8:6. PMID: 24575001; PMCID: PMC3918645.
    Citations: 4     
  82. Faghih RT, Dahleh MA, Adler GK, Klerman EB, Brown EN. Deconvolution of serum cortisol levels by using compressed sensing. PLoS One. 2014; 9(1):e85204. PMID: 24489656; PMCID: PMC3904842.
    Citations: 4     Fields:    Translation:Humans
  83. Ching S, Brown EN. Modeling the dynamical effects of anesthesia on brain circuits. Curr Opin Neurobiol. 2014 Apr; 25:116-22. PMID: 24457211; PMCID: PMC4181389.
    Citations: 13     Fields:    Translation:HumansCells
  84. Mukamel EA, Pirondini E, Babadi B, Wong KF, Pierce ET, Harrell PG, Walsh JL, Salazar-Gomez AF, Cash SS, Eskandar EN, Weiner VS, Brown EN, Purdon PL. A transition in brain state during propofol-induced unconsciousness. J Neurosci. 2014 Jan 15; 34(3):839-45. PMID: 24431442; PMCID: PMC3891963.
    Citations: 21     Fields:    Translation:Humans
  85. Akeju O, Brown EN. Awakened by a sleeping pill. Elife. 2013 Nov 19; 2:e01658. PMID: 24252876; PMCID: PMC3833341.
    Citations:    Fields:    Translation:Humans
  86. Liu M, Lewis LD, Shi R, Brown EN, Xu W. Differential requirement for NMDAR activity in SAP97ß-mediated regulation of the number and strength of glutamatergic AMPAR-containing synapses. J Neurophysiol. 2014 Feb; 111(3):648-58. PMID: 24225540; PMCID: PMC3921414.
    Citations: 3     Fields:    Translation:AnimalsCells
  87. Citi L, Ba D, Brown EN, Barbieri R. Likelihood methods for point processes with refractoriness. Neural Comput. 2014 Feb; 26(2):237-63. PMID: 24206384.
    Citations: 4     Fields:    
  88. Shanechi MM, Chemali JJ, Liberman M, Solt K, Brown EN. A brain-machine interface for control of medically-induced coma. PLoS Comput Biol. 2013 Oct; 9(10):e1003284. PMID: 24204231; PMCID: PMC3814408.
    Citations: 10     Fields:    Translation:Animals
  89. Babadi B, Ba D, Purdon PL, Brown EN. Convergence and Stability of a Class of Iteratively Re-weighted Least Squares Algorithms for Sparse Signal Recovery in the Presence of Noise. IEEE Trans Signal Process. 2013 Oct 30; 62(1):183-195. PMID: 26549965.
    Citations: 2     
  90. Ching S, Liberman MY, Chemali JJ, Westover MB, Kenny JD, Solt K, Purdon PL, Brown EN. Real-time closed-loop control in a rodent model of medically induced coma using burst suppression. Anesthesiology. 2013 Oct; 119(4):848-60. PMID: 23770601; PMCID: PMC3857134.
    Citations: 14     Fields:    Translation:Animals
  91. Babadi B, Obregon-Henao G, Lamus C, Hämäläinen MS, Brown EN, Purdon PL. A Subspace Pursuit-based Iterative Greedy Hierarchical solution to the neuromagnetic inverse problem. Neuroimage. 2014 Feb 15; 87:427-43. PMID: 24055554; PMCID: PMC3946905.
    Citations: 5     Fields:    Translation:Humans
  92. Chemali J, Ching S, Purdon PL, Solt K, Brown EN. Burst suppression probability algorithms: state-space methods for tracking EEG burst suppression. J Neural Eng. 2013 Oct; 10(5):056017. PMID: 24018288; PMCID: PMC3793904.
    Citations: 13     Fields:    Translation:AnimalsCells
  93. Brown EN, Purdon PL. The aging brain and anesthesia. Curr Opin Anaesthesiol. 2013 Aug; 26(4):414-9. PMID: 23820102.
    Citations: 8     Fields:    Translation:HumansAnimals
  94. Lewis LD, Ching S, Weiner VS, Peterfreund RA, Eskandar EN, Cash SS, Brown EN, Purdon PL. Local cortical dynamics of burst suppression in the anaesthetized brain. Brain. 2013 Sep; 136(Pt 9):2727-37. PMID: 23887187; PMCID: PMC3754454.
    Citations: 26     Fields:    Translation:Humans
  95. Brandon Westover M, Shafi MM, Ching S, Chemali JJ, Purdon PL, Cash SS, Brown EN. Real-time segmentation of burst suppression patterns in critical care EEG monitoring. J Neurosci Methods. 2013 Sep 30; 219(1):131-41. PMID: 23891828; PMCID: PMC3939433.
    Citations: 8     Fields:    Translation:Humans
  96. Vijayan S, Ching S, Purdon PL, Brown EN, Kopell NJ. Thalamocortical mechanisms for the anteriorization of a rhythms during propofol-induced unconsciousness. J Neurosci. 2013 Jul 03; 33(27):11070-5. PMID: 23825412; PMCID: PMC3718379.
    Citations: 35     Fields:    Translation:Humans
  97. Liberman MY, Ching S, Chemali J, Brown EN. A closed-loop anesthetic delivery system for real-time control of burst suppression. J Neural Eng. 2013 Aug; 10(4):046004. PMID: 23744607; PMCID: PMC3746775.
    Citations: 8     Fields:    Translation:HumansAnimals
  98. Shanechi MM, Williams ZM, Wornell GW, Hu RC, Powers M, Brown EN. A real-time brain-machine interface combining motor target and trajectory intent using an optimal feedback control design. PLoS One. 2013; 8(4):e59049. PMID: 23593130; PMCID: PMC3622681.
    Citations: 18     Fields:    Translation:Animals
  99. Purdon PL, Pierce ET, Mukamel EA, Prerau MJ, Walsh JL, Wong KF, Salazar-Gomez AF, Harrell PG, Sampson AL, Cimenser A, Ching S, Kopell NJ, Tavares-Stoeckel C, Habeeb K, Merhar R, Brown EN. Electroencephalogram signatures of loss and recovery of consciousness from propofol. Proc Natl Acad Sci U S A. 2013 Mar 19; 110(12):E1142-51. PMID: 23487781; PMCID: PMC3607036.
    Citations: 106     Fields:    Translation:HumansCTClinical Trials
  100. Taylor NE, Chemali JJ, Brown EN, Solt K. Activation of D1 dopamine receptors induces emergence from isoflurane general anesthesia. Anesthesiology. 2013 Jan; 118(1):30-9. PMID: 23221866; PMCID: PMC3527840.
    Citations: 22     Fields:    Translation:Animals
  101. Westover MB, Ching S, Shafi MM, Cash SS, Brown EN. Real-time segmentation and tracking of brain metabolic state in ICU EEG recordings of burst suppression. Conf Proc IEEE Eng Med Biol Soc. 2013; 2013:7108-11. PMID: 24111383; PMCID: PMC3939432.
    Citations: 6     Fields:    Translation:Humans
  102. Krishnaswamy P, Bonmassar G, Purdon PL, Brown EN. Reference-free harmonic regression technique to remove EEG-fMRI ballistocardiogram artifacts. Conf Proc IEEE Eng Med Biol Soc. 2013; 2013:5426-9. PMID: 24110963.
    Citations: 2     Fields:    Translation:Humans
  103. Shanechi MM, Chemali JJ, Liberman M, Solt K, Brown EN. A brain-machine interface for control of burst suppression in medical coma. Conf Proc IEEE Eng Med Biol Soc. 2013; 2013:1575-8. PMID: 24110002.
    Citations: 2     Fields:    Translation:Animals
  104. Vijayan S, Ching S, Purdon PL, Brown EN, Kopell NJ. Biophysical Modeling of Alpha Rhythms During Halothane-Induced Unconsciousness. Int IEEE EMBS Conf Neural Eng. 2013; 1104-1107. PMID: 25284633.
    Citations:    
  105. Schwinn DA, Mackensen GB, Brown EN. Understanding the TXA seizure connection. J Clin Invest. 2012 Dec; 122(12):4339-41. PMID: 23187134; PMCID: PMC3533567.
    Citations: 1     Fields:    Translation:HumansAnimals
  106. Shanechi MM, Hu RC, Powers M, Wornell GW, Brown EN, Williams ZM. Neural population partitioning and a concurrent brain-machine interface for sequential motor function. Nat Neurosci. 2012 Dec; 15(12):1715-22. PMID: 23143511; PMCID: PMC3509235.
    Citations: 13     Fields:    Translation:AnimalsCells
  107. Lewis LD, Weiner VS, Mukamel EA, Donoghue JA, Eskandar EN, Madsen JR, Anderson WS, Hochberg LR, Cash SS, Brown EN, Purdon PL. Rapid fragmentation of neuronal networks at the onset of propofol-induced unconsciousness. Proc Natl Acad Sci U S A. 2012 Dec 04; 109(49):E3377-86. PMID: 23129622; PMCID: PMC3523833.
    Citations: 101     Fields:    Translation:Humans
  108. Wong KF, Gong JJ, Cotten JF, Solt K, Brown EN. Assessing the effects of pharmacological agents on respiratory dynamics using time-series modeling. IEEE Trans Biomed Eng. 2013 Apr; 60(4):1118-25. PMID: 23193230.
    Citations:    Fields:    Translation:Animals
  109. Brown EN, Solt K. Management of opioid analgesic overdose. N Engl J Med. 2012 10 04; 367(14):1370-1; author reply 1372-3. PMID: 23034040.
    Citations:    Fields:    Translation:Humans
  110. Shanechi MM, Wornell GW, Williams ZM, Brown EN. Feedback-controlled parallel point process filter for estimation of goal-directed movements from neural signals. IEEE Trans Neural Syst Rehabil Eng. 2013 Jan; 21(1):129-40. PMID: 23047892.
    Citations: 10     Fields:    Translation:Animals
  111. Ching S, Brown EN, Kramer MA. Distributed control in a mean-field cortical network model: implications for seizure suppression. Phys Rev E Stat Nonlin Soft Matter Phys. 2012 Aug; 86(2 Pt 1):021920. PMID: 23005798.
    Citations: 9     Fields:    Translation:Cells
  112. Citi L, Brown EN, Barbieri R. A real-time automated point-process method for the detection and correction of erroneous and ectopic heartbeats. IEEE Trans Biomed Eng. 2012 Oct; 59(10):2828-37. PMID: 22875239; PMCID: PMC3523127.
    Citations: 9     Fields:    Translation:Humans
  113. Sarma SV, Cheng ML, Eden U, Williams Z, Brown EN, Eskandar E. The effects of cues on neurons in the basal ganglia in Parkinson's disease. Front Integr Neurosci. 2012; 6:40. PMID: 22855673.
    Citations: 5     
  114. Haslinger R, Pipa G, Lima B, Singer W, Brown EN, Neuenschwander S. Context matters: the illusive simplicity of macaque V1 receptive fields. PLoS One. 2012; 7(7):e39699. PMID: 22802940; PMCID: PMC3389039.
    Citations: 7     Fields:    Translation:AnimalsCells
  115. Pipa G, Chen Z, Neuenschwander S, Lima B, Brown EN. Mapping of visual receptive fields by tomographic reconstruction. Neural Comput. 2012 Oct; 24(10):2543-78. PMID: 22734491.
    Citations: 1     Fields:    Translation:Humans
  116. Chemali JJ, Van Dort CJ, Brown EN, Solt K. Active emergence from propofol general anesthesia is induced by methylphenidate. Anesthesiology. 2012 May; 116(5):998-1005. PMID: 22446983; PMCID: PMC3339625.
    Citations: 29     Fields:    Translation:Animals
  117. Temereanca S, Hämäläinen MS, Kuperberg GR, Stufflebeam SM, Halgren E, Brown EN. Eye movements modulate the spatiotemporal dynamics of word processing. J Neurosci. 2012 Mar 28; 32(13):4482-94. PMID: 22457496; PMCID: PMC3499987.
    Citations: 3     Fields:    Translation:Humans
  118. Shimazaki H, Amari S, Brown EN, Grün S. State-space analysis of time-varying higher-order spike correlation for multiple neural spike train data. PLoS Comput Biol. 2012; 8(3):e1002385. PMID: 22412358; PMCID: PMC3297562.
    Citations: 19     Fields:    Translation:AnimalsCells
  119. Kodituwakku S, Lazar SW, Indic P, Chen Z, Brown EN, Barbieri R. Point process time-frequency analysis of dynamic respiratory patterns during meditation practice. Med Biol Eng Comput. 2012 Mar; 50(3):261-75. PMID: 22350435; PMCID: PMC3341131.
    Citations: 3     Fields:    Translation:Humans
  120. Ching S, Purdon PL, Vijayan S, Kopell NJ, Brown EN. A neurophysiological-metabolic model for burst suppression. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):3095-100. PMID: 22323592; PMCID: PMC3286963.
    Citations: 60     Fields:    Translation:Humans
  121. Chen Z, Kloosterman F, Brown EN, Wilson MA. Uncovering spatial topology represented by rat hippocampal population neuronal codes. J Comput Neurosci. 2012 Oct; 33(2):227-55. PMID: 22307459; PMCID: PMC3974406.
    Citations: 7     Fields:    Translation:AnimalsCells
  122. Jarosiewicz B, Schummers J, Malik WQ, Brown EN, Sur M. Functional biases in visual cortex neurons with identified projections to higher cortical targets. Curr Biol. 2012 Feb 21; 22(4):269-77. PMID: 22305753; PMCID: PMC3288404.
    Citations: 11     Fields:    Translation:AnimalsCells
  123. Chen Z, Purdon PL, Brown EN, Barbieri R. A unified point process probabilistic framework to assess heartbeat dynamics and autonomic cardiovascular control. Front Physiol. 2012; 3:4. PMID: 22375120; PMCID: PMC3269663.
    Citations: 2     
  124. Citi L, Valenza G, Purdon PL, Brown EN, Barbieri R. Monitoring heartbeat nonlinear dynamics during general anesthesia by using the instantaneous dominant Lyapunov exponent. Conf Proc IEEE Eng Med Biol Soc. 2012; 2012:3124-7. PMID: 23366587.
    Citations: 2     Fields:    Translation:Humans
  125. Faghih RT, Savla K, Dahleh MA, Brown EN. Broad range of neural dynamics from a time-varying FitzHugh-Nagumo model and its spiking threshold estimation. IEEE Trans Biomed Eng. 2012 Mar; 59(3):816-23. PMID: 22186931.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  126. Lamus C, Hämäläinen MS, Temereanca S, Brown EN, Purdon PL. A spatiotemporal dynamic distributed solution to the MEG inverse problem. Neuroimage. 2012 Nov 01; 63(2):894-909. PMID: 22155043; PMCID: PMC3432302.
    Citations: 6     Fields:    Translation:Humans
  127. Putrino DF, Chen Z, Ghosh S, Brown EN. Motor cortical networks for skilled movements have dynamic properties that are related to accurate reaching. Neural Plast. 2011; 2011:413543. PMID: 22007332; PMCID: PMC3191785.
    Citations:    Fields:    Translation:AnimalsCells
  128. Solt K, Cotten JF, Cimenser A, Wong KF, Chemali JJ, Brown EN. Methylphenidate actively induces emergence from general anesthesia. Anesthesiology. 2011 Oct; 115(4):791-803. PMID: 21934407; PMCID: PMC3178041.
    Citations: 44     Fields:    Translation:Animals
  129. Phillips MA, Colonnese MT, Goldberg J, Lewis LD, Brown EN, Constantine-Paton M. A synaptic strategy for consolidation of convergent visuotopic maps. Neuron. 2011 Aug 25; 71(4):710-24. PMID: 21867886; PMCID: PMC3365514.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  130. Sarma SV, Nguyen DP, Czanner G, Wirth S, Wilson MA, Suzuki W, Brown EN. Computing confidence intervals for point process models. Neural Comput. 2011 Nov; 23(11):2731-45. PMID: 21851280.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  131. Brooks D, Brown EN, Casler R, Fantini S, Khademhosseini A, Niemi J, Ramachandran R, Rutkove S, Tracey B. Boston research takes center stage. Interview by Pamela Reynolds. IEEE Pulse. 2011 Jul-Aug; 2(4):31-8. PMID: 21791397.
    Citations:    Fields:    Translation:HumansAnimals
  132. Malik WQ, Schummers J, Sur M, Brown EN. Denoising two-photon calcium imaging data. PLoS One. 2011; 6(6):e20490. PMID: 21687727; PMCID: PMC3110192.
    Citations: 5     Fields:    Translation:AnimalsCells
  133. Long CJ, Purdon PL, Temereanca S, Desai NU, Hämäläinen MS, Brown EN. STATE-SPACE SOLUTIONS TO THE DYNAMIC MAGNETOENCEPHALOGRAPHY INVERSE PROBLEM USING HIGH PERFORMANCE COMPUTING. Ann Appl Stat. 2011 Jun 01; 5(2B):1207-1228. PMID: 22081780.
    Citations: 6     
  134. Cimenser A, Purdon PL, Pierce ET, Walsh JL, Salazar-Gomez AF, Harrell PG, Tavares-Stoeckel C, Habeeb K, Brown EN. Tracking brain states under general anesthesia by using global coherence analysis. Proc Natl Acad Sci U S A. 2011 May 24; 108(21):8832-7. PMID: 21555565; PMCID: PMC3102391.
    Citations: 68     Fields:    Translation:Humans
  135. Indic P, Bloch-Salisbury E, Bednarek F, Brown EN, Paydarfar D, Barbieri R. Assessment of cardio-respiratory interactions in preterm infants by bivariate autoregressive modeling and surrogate data analysis. Early Hum Dev. 2011 Jul; 87(7):477-87. PMID: 21511413; PMCID: PMC3114161.
    Citations: 3     Fields:    Translation:Humans
  136. LaCount LT, Barbieri R, Park K, Kim J, Brown EN, Kuo B, Napadow V. Static and dynamic autonomic response with increasing nausea perception. Aviat Space Environ Med. 2011 Apr; 82(4):424-33. PMID: 21485400; PMCID: PMC3137518.
    Citations: 11     Fields:    Translation:Humans
  137. Truccolo W, Donoghue JA, Hochberg LR, Eskandar EN, Madsen JR, Anderson WS, Brown EN, Halgren E, Cash SS. Single-neuron dynamics in human focal epilepsy. Nat Neurosci. 2011 May; 14(5):635-41. PMID: 21441925; PMCID: PMC3134302.
    Citations: 120     Fields:    Translation:HumansCells
  138. Kim S, Putrino D, Ghosh S, Brown EN. A Granger causality measure for point process models of ensemble neural spiking activity. PLoS Comput Biol. 2011 Mar; 7(3):e1001110. PMID: 21455283; PMCID: PMC3063721.
    Citations: 36     Fields:    Translation:AnimalsCells
  139. Wu W, Chen Z, Gao S, Brown EN. A hierarchical Bayesian approach for learning sparse spatio-temporal decompositions of multichannel EEG. Neuroimage. 2011 Jun 15; 56(4):1929-45. PMID: 21420499; PMCID: PMC3128889.
    Citations: 5     Fields:    Translation:Humans
  140. Krishnaswamy P, Brown EN, Herr HM. Human leg model predicts ankle muscle-tendon morphology, state, roles and energetics in walking. PLoS Comput Biol. 2011 Mar; 7(3):e1001107. PMID: 21445231; PMCID: PMC3060164.
    Citations: 11     Fields:    Translation:Humans
  141. Plourde E, Delgutte B, Brown EN. A point process model for auditory neurons considering both their intrinsic dynamics and the spectrotemporal properties of an extrinsic signal. IEEE Trans Biomed Eng. 2011 Jun; 58(6):1507-10. PMID: 21317068; PMCID: PMC3118674.
    Citations: 4     Fields:    Translation:AnimalsCells
  142. Barnes TD, Mao JB, Hu D, Kubota Y, Dreyer AA, Stamoulis C, Brown EN, Graybiel AM. Advance cueing produces enhanced action-boundary patterns of spike activity in the sensorimotor striatum. J Neurophysiol. 2011 Apr; 105(4):1861-78. PMID: 21307317; PMCID: PMC3075306.
    Citations: 7     Fields:    Translation:AnimalsCells
  143. Gong JJ, Wong KF, Cotten JF, Solt K, Brown EN. Correcting for serial dependence in studies of respiratory dynamics. Conf Proc IEEE Eng Med Biol Soc. 2011; 2011:1721-4. PMID: 22254658; PMCID: PMC3767304.
    Citations:    Fields:    Translation:Animals
  144. Faghih RT, Savla K, Dahleh MA, Brown EN. A feedback control model for cortisol secretion. Conf Proc IEEE Eng Med Biol Soc. 2011; 2011:716-9. PMID: 22254410.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  145. Wong KF, Mukamel EA, Salazar AF, Pierce ET, Harrell PG, Walsh JL, Sampson A, Brown EN, Purdon PL. Robust time-varying multivariate coherence estimation: application to electroencephalogram recordings during general anesthesia. Conf Proc IEEE Eng Med Biol Soc. 2011; 2011:4725-8. PMID: 22255393; PMCID: PMC3293406.
    Citations: 3     Fields:    Translation:Humans
  146. Chemali JJ, Wong KF, Solt K, Brown EN. A state-space model of the burst suppression ratio. Conf Proc IEEE Eng Med Biol Soc. 2011; 2011:1431-4. PMID: 22254587; PMCID: PMC3770149.
    Citations: 9     Fields:    Translation:AnimalsCells
  147. Chen Z, Vijayan S, Ching S, Hale G, Flores FJ, Wilson MA, Brown EN. Assessing neuronal interactions of cell assemblies during general anesthesia. Conf Proc IEEE Eng Med Biol Soc. 2011; 2011:4175-8. PMID: 22255259; PMCID: PMC3840037.
    Citations: 1     Fields:    Translation:HumansCells
  148. Mukamel EA, Wong KF, Prerau MJ, Brown EN, Purdon PL. Phase-based measures of cross-frequency coupling in brain electrical dynamics under general anesthesia. Conf Proc IEEE Eng Med Biol Soc. 2011; 2011:1981-4. PMID: 22254722; PMCID: PMC3282123.
    Citations: 12     Fields:    Translation:Humans
  149. Wong KF, Smith AC, Pierce ET, Harrell PG, Walsh JL, Salazar AF, Tavares CL, Cimenser A, Prerau MJ, Mukamel EA, Sampson A, Purdon PL, Brown EN. Bayesian analysis of trinomial data in behavioral experiments and its application to human studies of general anesthesia. Conf Proc IEEE Eng Med Biol Soc. 2011; 2011:4705-8. PMID: 22255388; PMCID: PMC3282046.
    Citations: 4     Fields:    Translation:Humans
  150. Brown EN, Purdon PL, Van Dort CJ. General anesthesia and altered states of arousal: a systems neuroscience analysis. Annu Rev Neurosci. 2011; 34:601-28. PMID: 21513454.
    Citations: 88     Fields:    Translation:HumansAnimals
  151. Chen Z, Citi L, Purdon PL, Brown EN, Barbieri R. Instantaneous assessment of autonomic cardiovascular control during general anesthesia. Conf Proc IEEE Eng Med Biol Soc. 2011; 2011:8444-7. PMID: 22256307; PMCID: PMC3299323.
    Citations: 2     Fields:    Translation:HumansCTClinical Trials
  152. Zheng HW, Malik WQ, Runyan CA, Sur M, Brown EN. Modeling two-photon calcium fluorescence of episodic V1 recordings using multifrequency analysis. Conf Proc IEEE Eng Med Biol Soc. 2011; 2011:3016-9. PMID: 22254975; PMCID: PMC4374803.
    Citations:    Fields:    Translation:Animals
  153. Citi L, Djilas M, Azevedo-Coste C, Yoshida K, Brown EN, Barbieri R. Point-process analysis of neural spiking activity of muscle spindles recorded from thin-film longitudinal intrafascicular electrodes. Conf Proc IEEE Eng Med Biol Soc. 2011; 2011:2311-4. PMID: 22254803; PMCID: PMC3275426.
    Citations: 1     Fields:    Translation:AnimalsCells
  154. Brown EN, Lydic R, Schiff ND. General anesthesia, sleep, and coma. N Engl J Med. 2010 Dec 30; 363(27):2638-50. PMID: 21190458; PMCID: PMC3162622.
    Citations: 187     Fields:    Translation:Humans
  155. Ching S, Cimenser A, Purdon PL, Brown EN, Kopell NJ. Thalamocortical model for a propofol-induced alpha-rhythm associated with loss of consciousness. Proc Natl Acad Sci U S A. 2010 Dec 28; 107(52):22665-70. PMID: 21149695; PMCID: PMC3012501.
    Citations: 87     Fields:    Translation:HumansCells
  156. Malik WQ, Truccolo W, Brown EN, Hochberg LR. Efficient decoding with steady-state Kalman filter in neural interface systems. IEEE Trans Neural Syst Rehabil Eng. 2011 Feb; 19(1):25-34. PMID: 21078582.
    Citations: