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Emery Neal Brown, Ph.D., M.D.

Title
Institution
Department
Address
Phone
Fax

Mentoring
completed student projects
Age-Dependent Effects of Propofol on Frontal Electroencephalogram Power
Summer, 06/05/14 - 08/22/14

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
Most Recent  |  List All
  1. R01MH115592 (MILLER, EARL K) Sep 8, 2017 - May 31, 2022
    NIH/NIMH
    Thalamocortical Dynamics and Consciousness
    Role: Co-Principal Investigator
  2. R01AG056015 (PURDON, PATRICK L.) Apr 15, 2017 - Mar 31, 2022
    NIH/NIA
    The Aging Brain Under General Anesthesia: Neurophysiology, Neuroimaging Biomarkers of Aging and Alzheimer's Disease, and Post-Operative Cognitive Outcomes
    Role: Co-Principal Investigator
  3. P01GM118269 (BROWN, EMERY N.) Feb 10, 2017 - Jan 31, 2022
    NIH/NIGMS
    Integrated Systems Neuroscience Studies of Anaesthesia
    Role: Principal Investigator
  4. R01EB022726 (BROWN, EMERY N.) Sep 30, 2016 - Jun 30, 2019
    NIH/NIBIB
    Filtered Point Process Inference Framework for Modeling Neural Data
    Role: Principal Investigator
  5. U01FD005935 (COOPER, THOMAS) Sep 15, 2016 - Aug 31, 2021
    FDA
    A Public-Private Partnership to support the investigation of anesthesia-related neurotoxicity in the pediatric population through non-clinical and clinical studies.
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Iaccarino HF, Singer AC, Martorell AJ, Rudenko A, Gao F, Gillingham TZ, Mathys H, Seo J, Kritskiy O, Abdurrob F, Adaikkan C, Canter RG, Rueda R, Brown EN, Boyden ES, Tsai LH. Author Correction: Gamma frequency entrainment attenuates amyloid load and modifies microglia. Nature. 2018 Oct; 562(7725):E1. PMID: 30046102.
    View in: PubMed
  2. Brown EN, Pavone KJ, Naranjo M. Multimodal General Anesthesia: Theory and Practice. Anesth Analg. 2018 Sep 24. PMID: 30252709.
    View in: PubMed
  3. Ionescu DF, Bentley KH, Eikermann M, Taylor N, Johnson-Akeju O, Swee MB, Pavone KJ, Petrie SR, Dording C, Mischoulon D, Alpert JE, Brown EN, Baer L, Nock MK, Fava M, Cusin C. Repeat-dose ketamine augmentation for treatment-resistant depression with chronic suicidal ideation: A randomized, double blind, placebo controlled trial. J Affect Disord. 2018 Sep 17; 243:516-524. PMID: 30286416.
    View in: PubMed
  4. Lewis LD, Piantoni G, Peterfreund RA, Eskandar EN, Harrell PG, Akeju O, Aglio LS, Cash SS, Brown EN, Mukamel EA, Purdon PL. A transient cortical state with sleep-like sensory responses precedes emergence from general anesthesia in humans. Elife. 2018 08 10; 7. PMID: 30095069.
    View in: PubMed
  5. Liu M, Shi R, Hwang H, Han KS, Wong MH, Ren X, Lewis LD, Brown EN, Xu W. SAP102 regulates synaptic AMPAR function through a CNIH-2-dependent mechanism. J Neurophysiol. 2018 Oct 01; 120(4):1578-1586. PMID: 30067114.
    View in: PubMed
  6. Walsh EC, Lee JM, Terzakis K, Zhou DW, Burns S, Buie TM, Firth PG, Shank ES, Houle TT, Brown EN, Purdon PL. Age-Dependent Changes in the Propofol-Induced Electroencephalogram in Children With Autism Spectrum Disorder. Front Syst Neurosci. 2018; 12:23. PMID: 29988455.
    View in: PubMed
  7. Chang YC, Khan S, Taulu S, Kuperberg G, Brown EN, Hämäläinen MS, Temereanca S. Left-Lateralized Contributions of Saccades to Cortical Activity During a One-Back Word Recognition Task. Front Neural Circuits. 2018; 12:38. PMID: 29867372.
    View in: PubMed
  8. Allsop SA, Wichmann R, Mills F, Burgos-Robles A, Chang CJ, Felix-Ortiz AC, Vienne A, Beyeler A, Izadmehr EM, Glober G, Cum MI, Stergiadou J, Anandalingam KK, Farris K, Namburi P, Leppla CA, Weddington JC, Nieh EH, Smith AC, Ba D, Brown EN, Tye KM. Corticoamygdala Transfer of Socially Derived Information Gates Observational Learning. Cell. 2018 May 31; 173(6):1329-1342.e18. PMID: 29731170.
    View in: PubMed
  9. Shelton KT, Qu J, Bilotta F, Brown EN, Cudemus G, D'Alessandro DA, Deng H, DiBiasio A, Gitlin JA, Hahm EY, Hobbs LE, Houle TT, Ibala R, Loggia ML, Pavone KJ, Shaefi S, Tolis G, Westover MB, Akeju O. Minimizing ICU Neurological Dysfunction with Dexmedetomidine-induced Sleep (MINDDS): protocol for a randomised, double-blind, parallel-arm, placebo-controlled trial. BMJ Open. 2018 04 20; 8(4):e020316. PMID: 29678977.
    View in: PubMed
  10. Brown EN, Purdon PL, Akeju O, An J. Using EEG markers to make inferences about anaesthetic-induced altered states of arousal. Br J Anaesth. 2018 Jul; 121(1):325-327. PMID: 29935587.
    View in: PubMed
  11. Kodandaramaiah SB, Flores FJ, Holst GL, Singer AC, Han X, Brown EN, Boyden ES, Forest CR. Multi-neuron intracellular recording in vivo via interacting autopatching robots. Elife. 2018 Jan 03; 7. PMID: 29297466.
    View in: PubMed
  12. Kim SE, Behr MK, Ba D, Brown EN. State-space multitaper time-frequency analysis. Proc Natl Acad Sci U S A. 2018 01 02; 115(1):E5-E14. PMID: 29255032.
    View in: PubMed
  13. Soplata AE, McCarthy MM, Sherfey J, Lee S, Purdon PL, Brown EN, Kopell N. Thalamocortical control of propofol phase-amplitude coupling. PLoS Comput Biol. 2017 12; 13(12):e1005879. PMID: 29227992.
    View in: PubMed
  14. Akeju O, Hobbs LE, Gao L, Burns SM, Pavone KJ, Plummer GS, Walsh EC, Houle TT, Kim SE, Bianchi MT, Ellenbogen JM, Brown EN. Dexmedetomidine promotes biomimetic non-rapid eye movement stage 3 sleep in humans: A pilot study. Clin Neurophysiol. 2018 01; 129(1):69-78. PMID: 29154132.
    View in: PubMed
  15. Lee JM, Akeju O, Terzakis K, Pavone KJ, Deng H, Houle TT, Firth PG, Shank ES, Brown EN, Purdon PL. A Prospective Study of Age-dependent Changes in Propofol-induced Electroencephalogram Oscillations in Children. Anesthesiology. 2017 08; 127(2):293-306. PMID: 28657957.
    View in: PubMed
  16. Flores FJ, Hartnack KE, Fath AB, Kim SE, Wilson MA, Brown EN, Purdon PL. Thalamocortical synchronization during induction and emergence from propofol-induced unconsciousness. Proc Natl Acad Sci U S A. 2017 08 08; 114(32):E6660-E6668. PMID: 28743752.
    View in: PubMed
  17. Guidera JA, Taylor NE, Lee JT, Vlasov KY, Pei J, Stephen EP, Mayo JP, Brown EN, Solt K. Sevoflurane Induces Coherent Slow-Delta Oscillations in Rats. Front Neural Circuits. 2017; 11:36. PMID: 28725184.
    View in: PubMed
  18. Faghih RT, Styer AK, Brown EN. Automated ovarian follicular monitoring: A novel real-time approach. Conf Proc IEEE Eng Med Biol Soc. 2017 07; 2017:632-635. PMID: 29059952.
    View in: PubMed
  19. Purdon PL, Solt K, Sims NM, Brown EN, Westover MB. Design, implementation, and evaluation of a physiological closed-loop control device for medically-induced coma. Conf Proc IEEE Eng Med Biol Soc. 2017 07; 2017:4313-4316. PMID: 29060851.
    View in: PubMed
  20. Song AH, Kucyi A, Napadow V, Brown EN, Loggia ML, Akeju O. Pharmacological Modulation of Noradrenergic Arousal Circuitry Disrupts Functional Connectivity of the Locus Ceruleus in Humans. J Neurosci. 2017 Jul 19; 37(29):6938-6945. PMID: 28626012.
    View in: PubMed
  21. Pavone KJ, Su L, Gao L, Eromo E, Vazquez R, Rhee J, Hobbs LE, Ibala R, Demircioglu G, Purdon PL, Brown EN, Akeju O. Lack of Responsiveness during the Onset and Offset of Sevoflurane Anesthesia Is Associated with Decreased Awake-Alpha Oscillation Power. Front Syst Neurosci. 2017; 11:38. PMID: 28611601.
    View in: PubMed
  22. Akeju O, Brown EN. Neural oscillations demonstrate that general anesthesia and sedative states are neurophysiologically distinct from sleep. Curr Opin Neurobiol. 2017 06; 44:178-185. PMID: 28544930.
    View in: PubMed
  23. Bianciardi M, Strong C, Toschi N, Edlow BL, Fischl B, Brown EN, Rosen BR, Wald LL. A probabilistic template of human mesopontine tegmental nuclei from in vivo 7T MRI. Neuroimage. 2018 04 15; 170:222-230. PMID: 28476663.
    View in: PubMed
  24. Brown EN, Behrmann M. Controversy in statistical analysis of functional magnetic resonance imaging data. Proc Natl Acad Sci U S A. 2017 04 25; 114(17):E3368-E3369. PMID: 28420797.
    View in: PubMed
  25. Hashmi JA, Loggia ML, Khan S, Gao L, Kim J, Napadow V, Brown EN, Akeju O. Dexmedetomidine Disrupts the Local and Global Efficiencies of Large-scale Brain Networks. Anesthesiology. 2017 Mar; 126(3):419-430. PMID: 28092321.
    View in: PubMed
  26. Cusin C, Ionescu DF, Pavone KJ, Akeju O, Cassano P, Taylor N, Eikermann M, Durham K, Swee MB, Chang T, Dording C, Soskin D, Kelley J, Mischoulon D, Brown EN, Fava M. Ketamine augmentation for outpatients with treatment-resistant depression: Preliminary evidence for two-step intravenous dose escalation. Aust N Z J Psychiatry. 2017 Jan; 51(1):55-64. PMID: 26893373.
    View in: PubMed
  27. Miran S, Purdon PL, Brown EN, Babadi B. Robust Estimation of Sparse Narrowband Spectra from Neuronal Spiking Data. IEEE Trans Biomed Eng. 2017 10; 64(10):2462-2474. PMID: 28026746.
    View in: PubMed
  28. Iaccarino HF, Singer AC, Martorell AJ, Rudenko A, Gao F, Gillingham TZ, Mathys H, Seo J, Kritskiy O, Abdurrob F, Adaikkan C, Canter RG, Rueda R, Brown EN, Boyden ES, Tsai LH. Gamma frequency entrainment attenuates amyloid load and modifies microglia. Nature. 2016 12 07; 540(7632):230-235. PMID: 27929004.
    View in: PubMed
  29. Kenny JD, Chemali JJ, Cotten JF, Van Dort CJ, Kim SE, Ba D, Taylor NE, Brown EN, Solt K. Physostigmine and Methylphenidate Induce Distinct Arousal States During Isoflurane General Anesthesia in Rats. Anesth Analg. 2016 11; 123(5):1210-1219. PMID: 26991753.
    View in: PubMed
  30. Lee MA, Bakh N, Bisker G, Brown EN, Strano MS. A Pharmacokinetic Model of a Tissue Implantable Cortisol Sensor. Adv Healthc Mater. 2016 12; 5(23):3004-3015. PMID: 27782371.
    View in: PubMed
  31. Taylor NE, Van Dort CJ, Kenny JD, Pei J, Guidera JA, Vlasov KY, Lee JT, Boyden ES, Brown EN, Solt K. Optogenetic activation of dopamine neurons in the ventral tegmental area induces reanimation from general anesthesia. Proc Natl Acad Sci U S A. 2016 Nov 08; 113(45):12826-12831. PMID: 27791160.
    View in: PubMed
  32. Akeju O, Kim SE, Vazquez R, Rhee J, Pavone KJ, Hobbs LE, Purdon PL, Brown EN. Spatiotemporal Dynamics of Dexmedetomidine-Induced Electroencephalogram Oscillations. PLoS One. 2016; 11(10):e0163431. PMID: 27711165.
    View in: PubMed
  33. Ishizawa Y, Ahmed OJ, Patel SR, Gale JT, Sierra-Mercado D, Brown EN, Eskandar EN. Dynamics of Propofol-Induced Loss of Consciousness Across Primate Neocortex. J Neurosci. 2016 07 20; 36(29):7718-26. PMID: 27445148; PMCID: PMC4951576 [Available on 01/20/17].
    View in: PubMed, PubMed Central
  34. Ionescu DF, Swee MB, Pavone KJ, Taylor N, Akeju O, Baer L, Nyer M, Cassano P, Mischoulon D, Alpert JE, Brown EN, Nock MK, Fava M, Cusin C. Rapid and Sustained Reductions in Current Suicidal Ideation Following Repeated Doses of Intravenous Ketamine: Secondary Analysis of an Open-Label Study. J Clin Psychiatry. 2016 06; 77(6):e719-25. PMID: 27232360.
    View in: PubMed
  35. Bianciardi M, Toschi N, Eichner C, Polimeni JR, Setsompop K, Brown EN, Hämäläinen MS, Rosen BR, Wald LL. In vivo functional connectome of human brainstem nuclei of the ascending arousal, autonomic, and motor systems by high spatial resolution 7-Tesla fMRI. MAGMA. 2016 Jun; 29(3):451-62. PMID: 27126248; PMCID: PMC4892960.
    View in: PubMed, PubMed Central
  36. Akeju O, Song AH, Hamilos AE, Pavone KJ, Flores FJ, Brown EN, Purdon PL. Electroencephalogram signatures of ketamine anesthesia-induced unconsciousness. Clin Neurophysiol. 2016 06; 127(6):2414-22. PMID: 27178861; PMCID: PMC4871620 [Available on 06/01/17].
    View in: PubMed, PubMed Central
  37. Muindi F, Kenny JD, Taylor NE, Solt K, Wilson MA, Brown EN, Van Dort CJ. Electrical stimulation of the parabrachial nucleus induces reanimation from isoflurane general anesthesia. Behav Brain Res. 2016 06 01; 306:20-5. PMID: 26971629.
    View in: PubMed
  38. Akeju O, Hamilos AE, Song AH, Pavone KJ, Purdon PL, Brown EN. GABAA circuit mechanisms are associated with ether anesthesia-induced unconsciousness. Clin Neurophysiol. 2016 Jun; 127(6):2472-81. PMID: 27178867; PMCID: PMC4869993 [Available on 06/01/17].
    View in: PubMed, PubMed Central
  39. Lewis LD, Voigts J, Flores FJ, Schmitt LI, Wilson MA, Halassa MM, Brown EN. Thalamic reticular nucleus induces fast and local modulation of arousal state. Elife. 2015 Oct 13; 4:e08760. PMID: 26460547; PMCID: PMC4686423.
    View in: PubMed, PubMed Central
  40. Purdon PL, Sampson A, Pavone KJ, Brown EN. Clinical Electroencephalography for Anesthesiologists: Part I: Background and Basic Signatures. Anesthesiology. 2015 Oct; 123(4):937-60. PMID: 26275092; PMCID: PMC4573341.
    View in: PubMed, PubMed Central
  41. Purdon PL, Zhou DW, Akeju O, Brown EN. In reply. Anesthesiology. 2015 Sep; 123(3):725-8. PMID: 26284863; PMCID: PMC4625800.
    View in: PubMed, PubMed Central
  42. Flores FJ, Ching S, Hartnack K, Fath AB, Purdon PL, Wilson MA, Brown EN. A PK-PD model of ketamine-induced high-frequency oscillations. J Neural Eng. 2015 Oct; 12(5):056006. PMID: 26268223.
    View in: PubMed
  43. Bianciardi M, Toschi N, Edlow BL, Eichner C, Setsompop K, Polimeni JR, Brown EN, Kinney HC, Rosen BR, Wald LL. Toward an In Vivo Neuroimaging Template of Human Brainstem Nuclei of the Ascending Arousal, Autonomic, and Motor Systems. Brain Connect. 2015 Dec; 5(10):597-607. PMID: 26066023; PMCID: PMC4684653 [Available on 12/01/16].
    View in: PubMed, PubMed Central
  44. Faghih RT, Dahleh MA, Brown EN. An optimization formulation for characterization of pulsatile cortisol secretion. Front Neurosci. 2015; 9:228. PMID: 26321898; PMCID: PMC4531247.
    View in: PubMed, PubMed Central
  45. Faghih RT, Stokes PA, Marin MF, Zsido RG, Zorowitz S, Rosenbaum BL, Milad MR, Dougherty DD, Eskandar EN, Widge AS, Brown EN, Barbieri R. Characterization of fear conditioning and fear extinction by analysis of electrodermal activity. Conf Proc IEEE Eng Med Biol Soc. 2015 Aug; 2015:7814-8. PMID: 26738104.
    View in: PubMed
  46. Kenny JD, Taylor NE, Brown EN, Solt K. Dextroamphetamine (but Not Atomoxetine) Induces Reanimation from General Anesthesia: Implications for the Roles of Dopamine and Norepinephrine in Active Emergence. PLoS One. 2015; 10(7):e0131914. PMID: 26148114; PMCID: PMC4492624.
    View in: PubMed, PubMed Central
  47. Krishnaswamy P, Bonmassar G, Poulsen C, Pierce ET, Purdon PL, Brown EN. Reference-free removal of EEG-fMRI ballistocardiogram artifacts with harmonic regression. Neuroimage. 2016 Mar; 128:398-412. PMID: 26151100; PMCID: PMC4761527 [Available on 03/01/17].
    View in: PubMed, PubMed Central
  48. Purdon PL, Pavone KJ, Akeju O, Smith AC, Sampson AL, Lee J, Zhou DW, Solt K, Brown EN. The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia. Br J Anaesth. 2015 Jul; 115 Suppl 1:i46-i57. PMID: 26174300; PMCID: PMC4501918.
    View in: PubMed, PubMed Central
  49. Van Dort CJ, Brown EN. Reply to Grace: Role of cholinergic neurons in rapid eye movement (REM) sleep control. Proc Natl Acad Sci U S A. 2015 Jul 21; 112(29):E3756. PMID: 26124152; PMCID: PMC4517216.
    View in: PubMed, PubMed Central
  50. Cornelissen L, Kim SE, Purdon PL, Brown EN, Berde CB. Age-dependent electroencephalogram (EEG) patterns during sevoflurane general anesthesia in infants. Elife. 2015 Jun 23; 4:e06513. PMID: 26102526; PMCID: PMC4502759.
    View in: PubMed, PubMed Central
  51. Pavone KJ, Akeju O, Sampson AL, Ling K, Purdon PL, Brown EN. Nitrous oxide-induced slow and delta oscillations. Clin Neurophysiol. 2016 Jan; 127(1):556-564. PMID: 26118489; PMCID: PMC4675698 [Available on 01/01/17].
    View in: PubMed, PubMed Central
  52. Westover MB, Kim SE, Ching S, Purdon PL, Brown EN. Robust control of burst suppression for medical coma. J Neural Eng. 2015 Aug; 12(4):046004. PMID: 26020243; PMCID: PMC4517835.
    View in: PubMed, PubMed Central
  53. Czanner G, Sarma SV, Ba D, Eden UT, Wu W, Eskandar E, Lim HH, Temereanca S, Suzuki WA, Brown EN. Measuring the signal-to-noise ratio of a neuron. Proc Natl Acad Sci U S A. 2015 Jun 09; 112(23):7141-6. PMID: 25995363; PMCID: PMC4466709.
    View in: PubMed, PubMed Central
  54. Jorgenson LA, Newsome WT, Anderson DJ, Bargmann CI, Brown EN, Deisseroth K, Donoghue JP, Hudson KL, Ling GS, MacLeish PR, Marder E, Normann RA, Sanes JR, Schnitzer MJ, Sejnowski TJ, Tank DW, Tsien RY, Ugurbil K, Wingfield JC. The BRAIN Initiative: developing technology to catalyse neuroscience discovery. Philos Trans R Soc Lond B Biol Sci. 2015 May 19; 370(1668). PMID: 25823863; PMCID: PMC4387507.
    View in: PubMed, PubMed Central
  55. Faghih RT, Dahleh MA, Adler GK, Klerman EB, Brown EN. Quantifying Pituitary-Adrenal Dynamics and Deconvolution of Concurrent Cortisol and Adrenocorticotropic Hormone Data by Compressed Sensing. IEEE Trans Biomed Eng. 2015 Oct; 62(10):2379-88. PMID: 25935025; PMCID: PMC4579049 [Available on 10/01/16].
    View in: PubMed, PubMed Central
  56. Song W, Cajigas I, Brown EN, Giszter SF. Adaptation to elastic loads and BMI robot controls during rat locomotion examined with point-process GLMs. Front Syst Neurosci. 2015; 9:62. PMID: 25972789; PMCID: PMC4411868.
    View in: PubMed, PubMed Central
  57. Westover MB, Ching S, Kumaraswamy VM, Akeju SO, Pierce E, Cash SS, Kilbride R, Brown EN, Purdon PL. The human burst suppression electroencephalogram of deep hypothermia. Clin Neurophysiol. 2015 Oct; 126(10):1901-1914. PMID: 25649968.
    View in: PubMed
  58. An J, Jonnalagadda D, Moura V, Purdon PL, Brown EN, Westover MB. Spatial variation in automated burst suppression detection in pharmacologically induced coma. Conf Proc IEEE Eng Med Biol Soc. 2015; 2015:7430-3. PMID: 26738009; PMCID: PMC4876722.
    View in: PubMed, PubMed Central
  59. Faghih RT, Barbieri R, Paulk AC, Asaad WF, Brown EN, Dougherty DD, Widge AS, Eskandar EN, Eden UT. Estimating a dynamic state to relate neural spiking activity to behavioral signals during cognitive tasks. Conf Proc IEEE Eng Med Biol Soc. 2015; 2015:7808-13. PMID: 26738103.
    View in: PubMed
  60. Ghassemi MM, Amorim E, Pati SB, Mark RG, Brown EN, Purdon PL, Westover MB. An enhanced cerebral recovery index for coma prognostication following cardiac arrest. Conf Proc IEEE Eng Med Biol Soc. 2015; 2015:534-7. PMID: 26736317.
    View in: PubMed
  61. Van Dort CJ, Zachs DP, Kenny JD, Zheng S, Goldblum RR, Gelwan NA, Ramos DM, Nolan MA, Wang K, Weng FJ, Lin Y, Wilson MA, Brown EN. Optogenetic activation of cholinergic neurons in the PPT or LDT induces REM sleep. Proc Natl Acad Sci U S A. 2015 Jan 13; 112(2):584-9. PMID: 25548191; PMCID: PMC4299243.
    View in: PubMed, PubMed Central
  62. Kenny JD, Westover MB, Ching S, Brown EN, Solt K. Propofol and sevoflurane induce distinct burst suppression patterns in rats. Front Syst Neurosci. 2014; 8:237. PMID: 25565990; PMCID: PMC4270179.
    View in: PubMed, PubMed Central
  63. Ba D, Babadi B, Purdon PL, Brown EN. Robust spectrotemporal decomposition by iteratively reweighted least squares. Proc Natl Acad Sci U S A. 2014 Dec 16; 111(50):E5336-45. PMID: 25468968; PMCID: PMC4273341.
    View in: PubMed, PubMed Central
  64. Akeju O, Loggia ML, Catana C, Pavone KJ, Vazquez R, Rhee J, Contreras Ramirez V, Chonde DB, Izquierdo-Garcia D, Arabasz G, Hsu S, Habeeb K, Hooker JM, Napadow V, Brown EN, Purdon PL. Disruption of thalamic functional connectivity is a neural correlate of dexmedetomidine-induced unconsciousness. Elife. 2014 Nov 28; 3:e04499. PMID: 25432022; PMCID: PMC4280551.
    View in: PubMed, PubMed Central
  65. Akeju O, Pavone KJ, Westover MB, Vazquez R, Prerau MJ, Harrell PG, Hartnack KE, Rhee J, Sampson AL, Habeeb K, Gao L, Lei G, Pierce ET, Walsh JL, Brown EN, Purdon PL. A comparison of propofol- and dexmedetomidine-induced electroencephalogram dynamics using spectral and coherence analysis. Anesthesiology. 2014 Nov; 121(5):978-89. PMID: 25187999; PMCID: PMC4304638.
    View in: PubMed, PubMed Central
  66. Akeju O, Westover MB, Pavone KJ, Sampson AL, Hartnack KE, Brown EN, Purdon PL. Effects of sevoflurane and propofol on frontal electroencephalogram power and coherence. Anesthesiology. 2014 Nov; 121(5):990-8. PMID: 25233374; PMCID: PMC4206606.
    View in: PubMed, PubMed Central
  67. Malik WQ, Hochberg LR, Donoghue JP, Brown EN. Modulation depth estimation and variable selection in state-space models for neural interfaces. IEEE Trans Biomed Eng. 2015 Feb; 62(2):570-81. PMID: 25265627.
    View in: PubMed
  68. Halassa MM, Chen Z, Wimmer RD, Brunetti PM, Zhao S, Zikopoulos B, Wang F, Brown EN, Wilson MA. State-dependent architecture of thalamic reticular subnetworks. Cell. 2014 Aug 14; 158(4):808-821. PMID: 25126786; PMCID: PMC4205482.
    View in: PubMed, PubMed Central
  69. Solt K, Van Dort CJ, Chemali JJ, Taylor NE, Kenny JD, Brown EN. Electrical stimulation of the ventral tegmental area induces reanimation from general anesthesia. Anesthesiology. 2014 Aug; 121(2):311-9. PMID: 24398816; PMCID: PMC4112744.
    View in: PubMed, PubMed Central
  70. Wu W, Chen Z, Gao X, Li Y, Brown EN, Gao S. Probabilistic Common Spatial Patterns for Multichannel EEG Analysis. IEEE Trans Pattern Anal Mach Intell. 2015 Mar; 37(3):639-53. PMID: 26005228; PMCID: PMC4441303.
    View in: PubMed, PubMed Central
  71. Babadi B, Brown EN. A review of multitaper spectral analysis. IEEE Trans Biomed Eng. 2014 May; 61(5):1555-64. PMID: 24759284.
    View in: PubMed
  72. Wong KF, Smith AC, Pierce ET, Harrell PG, Walsh JL, Salazar-Gómez AF, Tavares CL, Purdon PL, Brown EN. Statistical modeling of behavioral dynamics during propofol-induced loss of consciousness. J Neurosci Methods. 2014 Apr 30; 227:65-74. PMID: 24530701; PMCID: PMC4304648.
    View in: PubMed, PubMed Central
  73. Ba D, Temereanca S, Brown EN. Algorithms for the analysis of ensemble neural spiking activity using simultaneous-event multivariate point-process models. Front Comput Neurosci. 2014; 8:6. PMID: 24575001; PMCID: PMC3918645.
    View in: PubMed, PubMed Central
  74. Faghih RT, Dahleh MA, Adler GK, Klerman EB, Brown EN. Deconvolution of serum cortisol levels by using compressed sensing. PLoS One. 2014; 9(1):e85204. PMID: 24489656; PMCID: PMC3904842.
    View in: PubMed, PubMed Central
  75. Ching S, Brown EN. Modeling the dynamical effects of anesthesia on brain circuits. Curr Opin Neurobiol. 2014 Apr; 25:116-22. PMID: 24457211; PMCID: PMC4181389.
    View in: PubMed, PubMed Central
  76. Mukamel EA, Pirondini E, Babadi B, Wong KF, Pierce ET, Harrell PG, Walsh JL, Salazar-Gomez AF, Cash SS, Eskandar EN, Weiner VS, Brown EN, Purdon PL. A transition in brain state during propofol-induced unconsciousness. J Neurosci. 2014 Jan 15; 34(3):839-45. PMID: 24431442; PMCID: PMC3891963.
    View in: PubMed, PubMed Central
  77. Akeju O, Brown EN. Awakened by a sleeping pill. Elife. 2013 Nov 19; 2:e01658. PMID: 24252876; PMCID: PMC3833341.
    View in: PubMed, PubMed Central
  78. Liu M, Lewis LD, Shi R, Brown EN, Xu W. Differential requirement for NMDAR activity in SAP97ß-mediated regulation of the number and strength of glutamatergic AMPAR-containing synapses. J Neurophysiol. 2014 Feb; 111(3):648-58. PMID: 24225540; PMCID: PMC3921414.
    View in: PubMed, PubMed Central
  79. Citi L, Ba D, Brown EN, Barbieri R. Likelihood methods for point processes with refractoriness. Neural Comput. 2014 Feb; 26(2):237-63. PMID: 24206384.
    View in: PubMed
  80. Shanechi MM, Chemali JJ, Liberman M, Solt K, Brown EN. A brain-machine interface for control of medically-induced coma. PLoS Comput Biol. 2013 Oct; 9(10):e1003284. PMID: 24204231; PMCID: PMC3814408.
    View in: PubMed, PubMed Central
  81. Babadi B, Ba D, Purdon PL, Brown EN. Convergence and Stability of a Class of Iteratively Re-weighted Least Squares Algorithms for Sparse Signal Recovery in the Presence of Noise. IEEE Trans Signal Process. 2013 Oct 30; 62(1):183-195. PMID: 26549965.
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  110. Shimazaki H, Amari S, Brown EN, Grün S. State-space analysis of time-varying higher-order spike correlation for multiple neural spike train data. PLoS Comput Biol. 2012; 8(3):e1002385. PMID: 22412358; PMCID: PMC3297562.
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  125. Long CJ, Purdon PL, Temereanca S, Desai NU, Hämäläinen MS, Brown EN. STATE-SPACE SOLUTIONS TO THE DYNAMIC MAGNETOENCEPHALOGRAPHY INVERSE PROBLEM USING HIGH PERFORMANCE COMPUTING. Ann Appl Stat. 2011 Jun 01; 5(2B):1207-1228. PMID: 22081780.
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  127. Indic P, Bloch-Salisbury E, Bednarek F, Brown EN, Paydarfar D, Barbieri R. Assessment of cardio-respiratory interactions in preterm infants by bivariate autoregressive modeling and surrogate data analysis. Early Hum Dev. 2011 Jul; 87(7):477-87. PMID: 21511413; PMCID: PMC3114161.
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  128. LaCount LT, Barbieri R, Park K, Kim J, Brown EN, Kuo B, Napadow V. Static and dynamic autonomic response with increasing nausea perception. Aviat Space Environ Med. 2011 Apr; 82(4):424-33. PMID: 21485400; PMCID: PMC3137518.
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  129. Truccolo W, Donoghue JA, Hochberg LR, Eskandar EN, Madsen JR, Anderson WS, Brown EN, Halgren E, Cash SS. Single-neuron dynamics in human focal epilepsy. Nat Neurosci. 2011 May; 14(5):635-41. PMID: 21441925; PMCID: PMC3134302.
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  131. Wu W, Chen Z, Gao S, Brown EN. A hierarchical Bayesian approach for learning sparse spatio-temporal decompositions of multichannel EEG. Neuroimage. 2011 Jun 15; 56(4):1929-45. PMID: 21420499; PMCID: PMC3128889.
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  132. Krishnaswamy P, Brown EN, Herr HM. Human leg model predicts ankle muscle-tendon morphology, state, roles and energetics in walking. PLoS Comput Biol. 2011 Mar; 7(3):e1001107. PMID: 21445231; PMCID: PMC3060164.
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  133. Plourde E, Delgutte B, Brown EN. A point process model for auditory neurons considering both their intrinsic dynamics and the spectrotemporal properties of an extrinsic signal. IEEE Trans Biomed Eng. 2011 Jun; 58(6):1507-10. PMID: 21317068; PMCID: PMC3118674.
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  136. Faghih RT, Savla K, Dahleh MA, Brown EN. A feedback control model for cortisol secretion. Conf Proc IEEE Eng Med Biol Soc. 2011; 2011:716-9. PMID: 22254410.
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  148. Malik WQ, Truccolo W, Brown EN, Hochberg LR. Efficient decoding with steady-state Kalman filter in neural interface systems. IEEE Trans Neural Syst Rehabil Eng. 2011 Feb; 19(1):25-34. PMID: 21078582.
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  155. Sarma SV, Eden UT, Cheng ML, Williams ZM, Hu R, Eskandar E, Brown EN. Using point process models to compare neural spiking activity in the subthalamic nucleus of Parkinson's patients and a healthy primate. IEEE Trans Biomed Eng. 2010 Jun; 57(6):1297-305. PMID: 20172804; PMCID: PMC3822781.
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  156. Faghih RT, Savla K, Dahleh MA, Brown EN. The Fitzhugh-Nagumo model: Firing modes with time-varying parameters & parameter estimation. Conf Proc IEEE Eng Med Biol Soc. 2010; 2010:4116-9. PMID: 21096631.
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  159. Cajigas I, Goldsmith MT, Duschau-Wicke A, Riener R, Smith MA, Brown EN, Bonato P. Assessment of lower extremity motor adaptation via an extension of the force field adaptation paradigm. Conf Proc IEEE Eng Med Biol Soc. 2010; 2010:4522-5. PMID: 21095786; PMCID: PMC3306221.
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  166. Scholz J, Triantafyllou C, Whitfield-Gabrieli S, Brown EN, Saxe R. Distinct regions of right temporo-parietal junction are selective for theory of mind and exogenous attention. PLoS One. 2009; 4(3):e4869. PMID: 19290043; PMCID: PMC2653721.
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  172. Wu W, Chen Z, Gao S, Brown EN. A probabilistic framework for learning robust common spatial patterns. Conf Proc IEEE Eng Med Biol Soc. 2009; 2009:4658-61. PMID: 19963618.
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  174. Temereanca S, Brown EN, Simons DJ. Rapid changes in thalamic firing synchrony during repetitive whisker stimulation. J Neurosci. 2008 Oct 29; 28(44):11153-64. PMID: 18971458; PMCID: PMC2617717.
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  175. Yanike M, Wirth S, Smith AC, Brown EN, Suzuki WA. Comparison of associative learning-related signals in the macaque perirhinal cortex and hippocampus. Cereb Cortex. 2009 May; 19(5):1064-78. PMID: 18936274; PMCID: PMC2665157.
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  176. Napadow V, Dhond R, Conti G, Makris N, Brown EN, Barbieri R. Brain correlates of autonomic modulation: combining heart rate variability with fMRI. Neuroimage. 2008 Aug 01; 42(1):169-77. PMID: 18524629; PMCID: PMC2603289.
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  177. Barbieri R, Brown EN. Application of dynamic point process models to cardiovascular control. Biosystems. 2008 Jul-Aug; 93(1-2):120-5. PMID: 18515000; PMCID: PMC2561955.
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  178. Czanner G, Eden UT, Wirth S, Yanike M, Suzuki WA, Brown EN. Analysis of between-trial and within-trial neural spiking dynamics. J Neurophysiol. 2008 May; 99(5):2672-93. PMID: 18216233; PMCID: PMC2430469.
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  179. Chen Z, Brown EN, Barbieri R. Characterizing nonlinear heartbeat dynamics within a point process framework. Conf Proc IEEE Eng Med Biol Soc. 2008; 2008:2781-4. PMID: 19163282; PMCID: PMC2644067.
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  180. Nguyen DP, Barbieri R, Wilson MA, Brown EN. Instantaneous frequency and amplitude modulation of EEG in the hippocampus reveals state dependent temporal structure. Conf Proc IEEE Eng Med Biol Soc. 2008; 2008:1711-5. PMID: 19163009.
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  181. Barbieri R, Chen Z, Brown EN. Assessment of hippocampal and autonomic neural activity by point process models. Conf Proc IEEE Eng Med Biol Soc. 2008; 2008:3679. PMID: 19163509; PMCID: PMC2652877.
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  182. Eden UT, Brown EN. CONTINUOUS-TIME FILTERS FOR STATE ESTIMATION FROM POINT PROCESS MODELS OF NEURAL DATA. Stat Sin. 2008; 18(4):1293-1310. PMID: 22065511.
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  183. Zhang Q, Brown EN, Strangman GE. Adaptive filtering to reduce global interference in evoked brain activity detection: a human subject case study. J Biomed Opt. 2007 Nov-Dec; 12(6):064009. PMID: 18163825.
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  184. Zhang Q, Brown EN, Strangman GE. Adaptive filtering for global interference cancellation and real-time recovery of evoked brain activity: a Monte Carlo simulation study. J Biomed Opt. 2007 Jul-Aug; 12(4):044014. PMID: 17867818.
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  185. Srinivasan L, Eden UT, Mitter SK, Brown EN. General-purpose filter design for neural prosthetic devices. J Neurophysiol. 2007 Oct; 98(4):2456-75. PMID: 17522167.
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  186. Behn CG, Brown EN, Scammell TE, Kopell NJ. Mathematical model of network dynamics governing mouse sleep-wake behavior. J Neurophysiol. 2007 Jun; 97(6):3828-40. PMID: 17409167; PMCID: PMC2259448.
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  187. Ergün A, Barbieri R, Eden UT, Wilson MA, Brown EN. Construction of point process adaptive filter algorithms for neural systems using sequential Monte Carlo methods. IEEE Trans Biomed Eng. 2007 Mar; 54(3):419-28. PMID: 17355053.
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  188. Srinivasan L, Brown EN. A state-space framework for movement control to dynamic goals through brain-driven interfaces. IEEE Trans Biomed Eng. 2007 Mar; 54(3):526-35. PMID: 17355066.
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  189. Smith AC, Wirth S, Suzuki WA, Brown EN. Bayesian analysis of interleaved learning and response bias in behavioral experiments. J Neurophysiol. 2007 Mar; 97(3):2516-24. PMID: 17182907.
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  190. Srinivasan L, Eden UT, Willsky AS, Brown EN. A state-space analysis for reconstruction of goal-directed movements using neural signals. Neural Comput. 2006 Oct; 18(10):2465-94. PMID: 16907633.
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  191. Karameh FN, Dahleh MA, Brown EN, Massaquoi SG. Modeling the contribution of lamina 5 neuronal and network dynamics to low frequency EEG phenomena. Biol Cybern. 2006 Oct; 95(4):289-310. PMID: 16897093.
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  192. Barbieri R, Brown EN. Correction of erroneous and ectopic beats using a point process adaptive algorithm. Conf Proc IEEE Eng Med Biol Soc. 2006; 1:3373-6. PMID: 17945770.
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  193. Scotti S, Mauri M, Barbieri R, Jawad B, Cerutti S, Mainardi L, Brown EN, Villamira MA. Automatic quantitative evaluation of emotions in E-learning applications. Conf Proc IEEE Eng Med Biol Soc. 2006; 1:1359-62. PMID: 17946457.
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  194. Frank LM, Brown EN, Stanley GB. Hippocampal and cortical place cell plasticity: implications for episodic memory. Hippocampus. 2006; 16(9):775-84. PMID: 16921502.
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  195. Barbieri R, Brown EN. Analysis of heartbeat dynamics by point process adaptive filtering. IEEE Trans Biomed Eng. 2006 Jan; 53(1):4-12. PMID: 16402597.
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  196. Lee WC, Huang H, Feng G, Sanes JR, Brown EN, So PT, Nedivi E. Dynamic remodeling of dendritic arbors in GABAergic interneurons of adult visual cortex. PLoS Biol. 2006 Feb; 4(2):e29. PMID: 16366735; PMCID: PMC1318477.
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  197. Indic P, Brown EN. Characterizing the amplitude dynamics of the human core-temperature circadian rhythm using a stochastic-dynamic model. J Theor Biol. 2006 Apr 21; 239(4):499-506. PMID: 16223510.
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  198. Okatan M, Wilson MA, Brown EN. Analyzing functional connectivity using a network likelihood model of ensemble neural spiking activity. Neural Comput. 2005 Sep; 17(9):1927-61. PMID: 15992486.
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  199. Kass RE, Ventura V, Brown EN. Statistical issues in the analysis of neuronal data. J Neurophysiol. 2005 Jul; 94(1):8-25. PMID: 15985692.
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  200. Law JR, Flanery MA, Wirth S, Yanike M, Smith AC, Frank LM, Suzuki WA, Brown EN, Stark CE. Functional magnetic resonance imaging activity during the gradual acquisition and expression of paired-associate memory. J Neurosci. 2005 Jun 15; 25(24):5720-9. PMID: 15958738.
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  201. Barbieri R, Wilson MA, Frank LM, Brown EN. An analysis of hippocampal spatio-temporal representations using a Bayesian algorithm for neural spike train decoding. IEEE Trans Neural Syst Rehabil Eng. 2005 Jun; 13(2):131-6. PMID: 16003890.
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  202. Suzuki WA, Brown EN. Behavioral and neurophysiological analyses of dynamic learning processes. Behav Cogn Neurosci Rev. 2005 Jun; 4(2):67-95. PMID: 16251726.
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  203. Indic P, Forger DB, St Hilaire MA, Dean DA, Brown EN, Kronauer RE, Klerman EB, Jewett ME. Comparison of amplitude recovery dynamics of two limit cycle oscillator models of the human circadian pacemaker. Chronobiol Int. 2005; 22(4):613-29. PMID: 16147894; PMCID: PMC3797655.
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  204. Long C, Brown EN, Manoach D, Solo V. Spatiotemporal wavelet analysis for functional MRI. Neuroimage. 2004 Oct; 23(2):500-16. PMID: 15488399.
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  205. Smith AC, Stefani MR, Moghaddam B, Brown EN. Analysis and design of behavioral experiments to characterize population learning. J Neurophysiol. 2005 Mar; 93(3):1776-92. PMID: 15456798.
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  206. Barbieri R, Matten EC, Alabi AA, Brown EN. A point-process model of human heartbeat intervals: new definitions of heart rate and heart rate variability. Am J Physiol Heart Circ Physiol. 2005 Jan; 288(1):H424-35. PMID: 15374824.
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  207. Truccolo W, Eden UT, Fellows MR, Donoghue JP, Brown EN. A point process framework for relating neural spiking activity to spiking history, neural ensemble, and extrinsic covariate effects. J Neurophysiol. 2005 Feb; 93(2):1074-89. PMID: 15356183.
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  208. Frank LM, Stanley GB, Brown EN. Hippocampal plasticity across multiple days of exposure to novel environments. J Neurosci. 2004 Sep 01; 24(35):7681-9. PMID: 15342735.
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  209. Brown EN, Kass RE, Mitra PP. Multiple neural spike train data analysis: state-of-the-art and future challenges. Nat Neurosci. 2004 May; 7(5):456-61. PMID: 15114358.
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  210. Eden UT, Frank LM, Barbieri R, Solo V, Brown EN. Dynamic analysis of neural encoding by point process adaptive filtering. Neural Comput. 2004 May; 16(5):971-98. PMID: 15070506.
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  211. Barbieri R, Frank LM, Nguyen DP, Quirk MC, Solo V, Wilson MA, Brown EN. Dynamic analyses of information encoding in neural ensembles. Neural Comput. 2004 Feb; 16(2):277-307. PMID: 15006097.
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  212. Smith AC, Frank LM, Wirth S, Yanike M, Hu D, Kubota Y, Graybiel AM, Suzuki WA, Brown EN. Dynamic analysis of learning in behavioral experiments. J Neurosci. 2004 Jan 14; 24(2):447-61. PMID: 14724243.
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  213. Brown EN, Solo V, Choe Y, Zhang Z. Measuring period of human biological clock: infill asymptotic analysis of harmonic regression parameter estimates. Methods Enzymol. 2004; 383:382-405. PMID: 15063659.
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  214. Frank LM, Brown EN. Persistent activity and memory in the entorhinal cortex. Trends Neurosci. 2003 Aug; 26(8):400-1. PMID: 12900167.
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  215. Klerman EB, Adler GK, Jin M, Maliszewski AM, Brown EN. A statistical model of diurnal variation in human growth hormone. Am J Physiol Endocrinol Metab. 2003 Nov; 285(5):E1118-26. PMID: 12888486.
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  216. Wirth S, Yanike M, Frank LM, Smith AC, Brown EN, Suzuki WA. Single neurons in the monkey hippocampus and learning of new associations. Science. 2003 Jun 06; 300(5625):1578-81. PMID: 12791995.
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  217. Smith AC, Brown EN. Estimating a state-space model from point process observations. Neural Comput. 2003 May; 15(5):965-91. PMID: 12803953.
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  218. Nguyen DP, Frank LM, Brown EN. An application of reversible-jump Markov chain Monte Carlo to spike classification of multi-unit extracellular recordings. Network. 2003 Feb; 14(1):61-82. PMID: 12617059.
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  219. Bonmassar G, Purdon PL, Jääskeläinen IP, Chiappa K, Solo V, Brown EN, Belliveau JW. Motion and ballistocardiogram artifact removal for interleaved recording of EEG and EPs during MRI. Neuroimage. 2002 Aug; 16(4):1127-41. PMID: 12202099.
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  220. Frank LM, Eden UT, Solo V, Wilson MA, Brown EN. Contrasting patterns of receptive field plasticity in the hippocampus and the entorhinal cortex: an adaptive filtering approach. J Neurosci. 2002 May 01; 22(9):3817-30. PMID: 11978857.
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  221. Brown EN, Barbieri R, Ventura V, Kass RE, Frank LM. The time-rescaling theorem and its application to neural spike train data analysis. Neural Comput. 2002 Feb; 14(2):325-46. PMID: 11802915.
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  222. Brown EN, Nguyen DP, Frank LM, Wilson MA, Solo V. An analysis of neural receptive field plasticity by point process adaptive filtering. Proc Natl Acad Sci U S A. 2001 Oct 09; 98(21):12261-6. PMID: 11593043; PMCID: PMC59830.
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©2018 President and Fellows of Harvard College
Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.