Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Emery Neal Brown, Ph.D., M.D.

Title
Institution
Department
Address
Phone
Fax

Mentoring
completed student projects
Age-Dependent Effects of Propofol on Frontal Electroencephalogram Power
Summer, 06/05/14 - 08/22/14

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01MH115592 (MILLER, EARL K) Sep 8, 2017 - May 31, 2022
    NIH
    Thalamocortical Dynamics and Consciousness
    Role: Co-Principal Investigator
  2. R01AG056015 (PURDON, PATRICK L.) Apr 15, 2017 - Mar 31, 2022
    NIH
    The Aging Brain Under General Anesthesia: Neurophysiology, Neuroimaging Biomarkers of Aging and Alzheimer's Disease, and Post-Operative Cognitive Outcomes
    Role: Co-Principal Investigator
  3. P01GM118269 (BROWN, EMERY N.) Feb 10, 2017 - Jan 31, 2022
    NIH
    Integrated Systems Neuroscience Studies of Anaesthesia
    Role: Principal Investigator
  4. R01EB022726 (BROWN, EMERY N.) Sep 30, 2016 - Jun 30, 2020
    NIH
    Filtered Point Process Inference Framework for Modeling Neural Data
    Role: Principal Investigator
  5. U01FD005935 (COOPER, THOMAS) Sep 15, 2016 - Aug 31, 2021
    NIH
    A Public-Private Partnership to support the investigation of anesthesia-related neurotoxicity in the pediatric population through non-clinical and clinical studies.
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Subramanian S, Purdon P, Barbieri R, Brown EN. A Model-Based Approach for Pulse Selection from Electrodermal Activity. IEEE Trans Biomed Eng. 2021 Apr 06; PP. PMID: 33822719.
    Citations:    Fields:    
  2. Guay CS, Labonte AK, Montana MC, Landsness EC, Lucey BP, Kafashan M, Haroutounian S, Avidan MS, Brown EN, Palanca BJA. Closed-Loop Acoustic Stimulation During Sedation with Dexmedetomidine (CLASS-D): Protocol for a Within-Subject, Crossover, Controlled, Interventional Trial with Healthy Volunteers. Nat Sci Sleep. 2021; 13:303-313. PMID: 33692642.
    Citations:    
  3. Casile A, Faghih RT, Brown EN. Robust point-process Granger causality analysis in presence of exogenous temporal modulations and trial-by-trial variability in spike trains. PLoS Comput Biol. 2021 Jan; 17(1):e1007675. PMID: 33493162.
    Citations:    Fields:    
  4. Conklin J, Frosch MP, Mukerji SS, Rapalino O, Maher MD, Schaefer PW, Lev MH, Gonzalez RG, Das S, Champion SN, Magdamo C, Sen P, Harrold GK, Alabsi H, Normandin E, Shaw B, Lemieux JE, Sabeti PC, Branda JA, Brown EN, Westover MB, Huang SY, Edlow BL. Susceptibility-weighted imaging reveals cerebral microvascular injury in severe COVID-19. J Neurol Sci. 2021 02 15; 421:117308. PMID: 33497950.
    Citations: 1     Fields:    Translation:Humans
  5. Edlow BL, Claassen J, Victor JD, Brown EN, Schiff ND. Delayed reemergence of consciousness in survivors of severe COVID-19. Neurocrit Care. 2020 12; 33(3):627-629. PMID: 33174149.
    Citations: 1     Fields:    Translation:Humans
  6. Shao YR, Kahali P, Houle TT, Deng H, Colvin C, Dickerson BC, Brown EN, Purdon PL. Low Frontal Alpha Power Is Associated With the Propensity for Burst Suppression: An Electroencephalogram Phenotype for a "Vulnerable Brain". Anesth Analg. 2020 11; 131(5):1529-1539. PMID: 33079876.
    Citations:    Fields:    Translation:Humans
  7. Subramanian S, Barbieri R, Brown EN. Point process temporal structure characterizes electrodermal activity. Proc Natl Acad Sci U S A. 2020 10 20; 117(42):26422-26428. PMID: 33008878.
    Citations:    Fields:    Translation:Humans
  8. Stephen EP, Hotan GC, Pierce ET, Harrell PG, Walsh JL, Brown EN, Purdon PL. Broadband slow-wave modulation in posterior and anterior cortex tracks distinct states of propofol-induced unconsciousness. Sci Rep. 2020 08 13; 10(1):13701. PMID: 32792556.
    Citations:    Fields:    Translation:Humans
  9. Edlow BL, Barra ME, Zhou DW, Foulkes AS, Snider SB, Threlkeld ZD, Chakravarty S, Kirsch JE, Chan ST, Meisler SL, Bleck TP, Fins JJ, Giacino JT, Hochberg LR, Solt K, Brown EN, Bodien YG. Personalized Connectome Mapping to Guide Targeted Therapy and Promote Recovery of Consciousness in the Intensive Care Unit. Neurocrit Care. 2020 10; 33(2):364-375. PMID: 32794142.
    Citations: 2     Fields:    
  10. Conklin J, Frosch MP, Mukerji S, Rapalino O, Maher M, Schaefer PW, Lev MH, Gonzalez RG, Das S, Champion SN, Magdamo C, Sen P, Harrold GK, Alabsi H, Normandin E, Shaw B, Lemieux J, Sabeti P, Branda JA, Brown EN, Westover MB, Huang SY, Edlow BL. Cerebral Microvascular Injury in Severe COVID-19. medRxiv. 2020 Jul 24. PMID: 32743599.
    Citations:    
  11. Subramanian S, Barbieri R, Purdon PL, Brown EN. Detecting Loss and Regain of Consciousness during Propofol Anesthesia using Multimodal Indices of Autonomic State. Annu Int Conf IEEE Eng Med Biol Soc. 2020 07; 2020:824-827. PMID: 33018112.
    Citations:    Translation:Humans
  12. Shao YR, Kahali P, Houle TT, Deng H, Colvin C, Dickerson BC, Brown EN, Purdon PL. Low Frontal Alpha Power Is Associated With the Propensity for Burst Suppression: An Electroencephalogram Phenotype for a "Vulnerable Brain". Anesth Analg. 2020 May 14. PMID: 32427658.
    Citations:    Fields:    
  13. Chakravarty S, Threlkeld ZD, Bodien YG, Edlow BL, Brown EN. A state-space model for dynamic functional connectivity. Conf Rec Asilomar Conf Signals Syst Comput. 2019 Nov; 2019:240-244. PMID: 32801606.
    Citations:    
  14. Koroshetz WJ, Behrman S, Brame CJ, Branchaw JL, Brown EN, Clark EA, Dockterman D, Elm JJ, Gay PL, Green KM, Hsi S, Kaplitt MG, Kolber BJ, Kolodkin AL, Lipscombe D, MacLeod MR, McKinney CC, Munafò MR, Oakley B, Olimpo JT, Percie du Sert N, Raman IM, Riley C, Shelton AL, Uzzo SM, Crawford DC, Silberberg SD. Framework for advancing rigorous research. Elife. 2020 03 04; 9. PMID: 32127131.
    Citations: 2     Fields:    
  15. Chamadia S, Pedemonte JC, Hahm EY, Mekonnen J, Ibala R, Gitlin J, Ethridge BR, Qu J, Vazquez R, Rhee J, Liao ET, Brown EN, Akeju O. Delta oscillations phase limit neural activity during sevoflurane anesthesia. Commun Biol. 2019; 2:415. PMID: 31754645.
    Citations: 6     Translation:HumansCells
  16. Chamadia S, Pedemonte JC, Hahm EY, Mekonnen J, Ibala R, Gitlin J, Ethridge BR, Qu J, Vazquez R, Rhee J, Liao ET, Brown EN, Akeju O. Delta oscillations phase limit neural activity during sevoflurane anesthesia. Commun Biol. 2019 Nov 15; 2(1):415. PMID: 31925268.
    Citations:    
  17. Agrawal U, Brown EN, Lewis LD. Model-based physiological noise removal in fast fMRI. Neuroimage. 2020 01 15; 205:116231. PMID: 31589991.
    Citations: 2     Fields:    Translation:Humans
  18. Koch S, Feinkohl I, Chakravarty S, Windmann V, Lichtner G, Pischon T, Brown EN, Spies C. Cognitive Impairment Is Associated with Absolute Intraoperative Frontal a-Band Power but Not with Baseline a-Band Power: A Pilot Study. Dement Geriatr Cogn Disord. 2019; 48(1-2):83-92. PMID: 31578031.
    Citations: 1     Fields:    Translation:Humans
  19. Brown EN. Neurologic Examination for Anesthesiologists: Reply. Anesthesiology. 2019 10; 131(4):946. PMID: 31436546.
    Citations:    Fields:    Translation:Humans
  20. Ghassemi MM, Amorim E, Alhanai T, Lee JW, Herman ST, Sivaraju A, Gaspard N, Hirsch LJ, Scirica BM, Biswal S, Moura Junior V, Cash SS, Brown EN, Mark RG, Westover MB. Quantitative Electroencephalogram Trends Predict Recovery in Hypoxic-Ischemic Encephalopathy. Crit Care Med. 2019 10; 47(10):1416-1423. PMID: 31241498.
    Citations: 1     Fields:    Translation:Humans
  21. Snider SB, Bodien YG, Bianciardi M, Brown EN, Wu O, Edlow BL. Disruption of the ascending arousal network in acute traumatic disorders of consciousness. Neurology. 2019 09 24; 93(13):e1281-e1287. PMID: 31484715.
    Citations: 4     Fields:    Translation:Humans
  22. Windmann V, Spies C, Brown EN, Kishnan D, Lichtner G, Koch S. Influence of midazolam premedication on intraoperative EEG signatures in elderly patients. Clin Neurophysiol. 2019 09; 130(9):1673-1681. PMID: 31351371.
    Citations: 1     Fields:    Translation:HumansCTClinical Trials
  23. Chakravarty S, Baum TE, An J, Kahali P, Brown EN. A hidden semi-Markov model for estimating burst suppression EEG. Annu Int Conf IEEE Eng Med Biol Soc. 2019 Jul; 2019:7076-7079. PMID: 31947467.
    Citations:    
  24. Yousefi A, Fard RS, Eden UT, Brown EN. State-Space Global Coherence to Estimate the Spatio-Temporal Dynamics of the Coordinated Brain Activity. Annu Int Conf IEEE Eng Med Biol Soc. 2019 Jul; 2019:5794-5798. PMID: 31947169.
    Citations:    Translation:Humans
  25. Subramanian S, Barbieri R, Brown EN. A Systematic Method for Preprocessing and Analyzing Electrodermal Activity. Annu Int Conf IEEE Eng Med Biol Soc. 2019 Jul; 2019:6902-6905. PMID: 31947426.
    Citations: 1     Translation:Humans
  26. Brown EN. In Response. Anesth Analg. 2019 06; 128(6):e131. PMID: 31094828.
    Citations:    Fields:    
  27. Brown EN. In Response. Anesth Analg. 2019 Apr 08. PMID: 30985374.
    Citations:    
  28. MacCormick IJC, Williams BM, Zheng Y, Li K, Al-Bander B, Czanner S, Cheeseman R, Willoughby CE, Brown EN, Spaeth GL, Czanner G. Correction: Accurate, fast, data efficient and interpretable glaucoma diagnosis with automated spatial analysis of the whole cup to disc profile. PLoS One. 2019; 14(4):e0215056. PMID: 30943257.
    Citations:    Fields:    
  29. Martorell AJ, Paulson AL, Suk HJ, Abdurrob F, Drummond GT, Guan W, Young JZ, Kim DN, Kritskiy O, Barker SJ, Mangena V, Prince SM, Brown EN, Chung K, Boyden ES, Singer AC, Tsai LH. Multi-sensory Gamma Stimulation Ameliorates Alzheimer's-Associated Pathology and Improves Cognition. Cell. 2019 04 04; 177(2):256-271.e22. PMID: 30879788.
    Citations: 43     Fields:    Translation:AnimalsCells
  30. Yang Y, Lee JT, Guidera JA, Vlasov KY, Pei J, Brown EN, Solt K, Shanechi MM. Developing a personalized closed-loop controller of medically-induced coma in a rodent model. J Neural Eng. 2019 06; 16(3):036022. PMID: 30856619.
    Citations: 5     Fields:    Translation:Animals
  31. Reshef ER, Schiff ND, Brown EN. A Neurologic Examination for Anesthesiologists: Assessing Arousal Level during Induction, Maintenance, and Emergence. Anesthesiology. 2019 03; 130(3):462-471. PMID: 30664547.
    Citations: 3     Fields:    Translation:Humans
  32. Taylor NE, Pei J, Zhang J, Vlasov KY, Davis T, Taylor E, Weng FJ, Van Dort CJ, Solt K, Brown EN. The Role of Glutamatergic and Dopaminergic Neurons in the Periaqueductal Gray/Dorsal Raphe: Separating Analgesia and Anxiety. eNeuro. 2019 Jan-Feb; 6(1). PMID: 31058210.
    Citations: 11     Fields:    Translation:AnimalsCells
  33. MacCormick IJC, Williams BM, Zheng Y, Li K, Al-Bander B, Czanner S, Cheeseman R, Willoughby CE, Brown EN, Spaeth GL, Czanner G. Accurate, fast, data efficient and interpretable glaucoma diagnosis with automated spatial analysis of the whole cup to disc profile. PLoS One. 2019; 14(1):e0209409. PMID: 30629635.
    Citations: 4     Fields:    Translation:Humans
  34. Brown EN, Pavone KJ, Naranjo M. Multimodal General Anesthesia: Theory and Practice. Anesth Analg. 2018 11; 127(5):1246-1258. PMID: 30252709.
    Citations: 21     Fields:    Translation:Humans
  35. An J, Jonnalagadda D, Moura V, Purdon PL, Brown EN, Westover MB. Variability in pharmacologically-induced coma for treatment of refractory status epilepticus. PLoS One. 2018; 13(10):e0205789. PMID: 30379935.
    Citations: 1     Fields:    Translation:HumansCTClinical Trials
  36. Kim SE, Ba D, Brown EN. A Multitaper Frequency-Domain Bootstrap Method. IEEE Signal Process Lett. 2018 Dec; 25(12):1805-1809. PMID: 32002009.
    Citations:    
  37. Iaccarino HF, Singer AC, Martorell AJ, Rudenko A, Gao F, Gillingham TZ, Mathys H, Seo J, Kritskiy O, Abdurrob F, Adaikkan C, Canter RG, Rueda R, Brown EN, Boyden ES, Tsai LH. Author Correction: Gamma frequency entrainment attenuates amyloid load and modifies microglia. Nature. 2018 10; 562(7725):E1. PMID: 30046102.
    Citations: 2     Fields:    
  38. Ionescu DF, Bentley KH, Eikermann M, Taylor N, Akeju O, Swee MB, Pavone KJ, Petrie SR, Dording C, Mischoulon D, Alpert JE, Brown EN, Baer L, Nock MK, Fava M, Cusin C. Repeat-dose ketamine augmentation for treatment-resistant depression with chronic suicidal ideation: A randomized, double blind, placebo controlled trial. J Affect Disord. 2019 01 15; 243:516-524. PMID: 30286416.
    Citations: 14     Fields:    Translation:Humans
  39. Lewis LD, Piantoni G, Peterfreund RA, Eskandar EN, Harrell PG, Akeju O, Aglio LS, Cash SS, Brown EN, Mukamel EA, Purdon PL. A transient cortical state with sleep-like sensory responses precedes emergence from general anesthesia in humans. Elife. 2018 08 10; 7. PMID: 30095069.
    Citations: 5     Fields:    Translation:Humans
  40. Liu M, Shi R, Hwang H, Han KS, Wong MH, Ren X, Lewis LD, Brown EN, Xu W. SAP102 regulates synaptic AMPAR function through a CNIH-2-dependent mechanism. J Neurophysiol. 2018 10 01; 120(4):1578-1586. PMID: 30067114.
    Citations: 1     Fields:    Translation:AnimalsCells
  41. Subramanian S, Barbieri R, Brown EN. A Point Process Characterization Of Electrodermal Activity. Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul; 2018:37-40. PMID: 30440335.
    Citations: 1     Translation:Humans
  42. An J, Flores FJ, Kodandaramaiah SB, Dalla Betta I, Nikolaeva K, Boyden ES, Forest CR, Brown EN. Automated Assessment of Loss of Consciousness Using Whisker And Paw Movements During Anesthetic Dosing in Head-Fixed Rodents. Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul; 2018:730-733. PMID: 30440500.
    Citations: 1     Translation:HumansAnimals
  43. Song AH, Chakravarty S, Brown EN. A Smoother State Space Multitaper Spectrogram. Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul; 2018:33-36. PMID: 30440334.
    Citations:    Translation:Humans
  44. Walsh EC, Lee JM, Terzakis K, Zhou DW, Burns S, Buie TM, Firth PG, Shank ES, Houle TT, Brown EN, Purdon PL. Age-Dependent Changes in the Propofol-Induced Electroencephalogram in Children With Autism Spectrum Disorder. Front Syst Neurosci. 2018; 12:23. PMID: 29988455.
    Citations:    
  45. Chang YC, Khan S, Taulu S, Kuperberg G, Brown EN, Hämäläinen MS, Temereanca S. Left-Lateralized Contributions of Saccades to Cortical Activity During a One-Back Word Recognition Task. Front Neural Circuits. 2018; 12:38. PMID: 29867372.
    Citations:    Fields:    Translation:HumansCells
  46. Allsop SA, Wichmann R, Mills F, Burgos-Robles A, Chang CJ, Felix-Ortiz AC, Vienne A, Beyeler A, Izadmehr EM, Glober G, Cum MI, Stergiadou J, Anandalingam KK, Farris K, Namburi P, Leppla CA, Weddington JC, Nieh EH, Smith AC, Ba D, Brown EN, Tye KM. Corticoamygdala Transfer of Socially Derived Information Gates Observational Learning. Cell. 2018 05 31; 173(6):1329-1342.e18. PMID: 29731170.
    Citations: 31     Fields:    Translation:AnimalsCells
  47. Shelton KT, Qu J, Bilotta F, Brown EN, Cudemus G, D'Alessandro DA, Deng H, DiBiasio A, Gitlin JA, Hahm EY, Hobbs LE, Houle TT, Ibala R, Loggia ML, Pavone KJ, Shaefi S, Tolis G, Westover MB, Akeju O. Minimizing ICU Neurological Dysfunction with Dexmedetomidine-induced Sleep (MINDDS): protocol for a randomised, double-blind, parallel-arm, placebo-controlled trial. BMJ Open. 2018 04 20; 8(4):e020316. PMID: 29678977.
    Citations: 10     Fields:    Translation:Humans
  48. Brown EN, Purdon PL, Akeju O, An J. Using EEG markers to make inferences about anaesthetic-induced altered states of arousal. Br J Anaesth. 2018 07; 121(1):325-327. PMID: 29935587.
    Citations: 4     Fields:    
  49. Kodandaramaiah SB, Flores FJ, Holst GL, Singer AC, Han X, Brown EN, Boyden ES, Forest CR. Multi-neuron intracellular recording in vivo via interacting autopatching robots. Elife. 2018 01 03; 7. PMID: 29297466.
    Citations: 9     Fields:    Translation:AnimalsCells
  50. Chakravarty S, Nikolaeva K, Kishnan D, Flores FJ, Purdon PL, Brown EN. Pharmacodynamic modeling of propofol-induced general anesthesia in young adults. Health Innov Point Care Conf. 2017 Nov; 2017:44-47. PMID: 32803192.
    Citations:    
  51. Kim SE, Behr MK, Ba D, Brown EN. State-space multitaper time-frequency analysis. Proc Natl Acad Sci U S A. 2018 01 02; 115(1):E5-E14. PMID: 29255032.
    Citations: 7     Fields:    Translation:Humans
  52. Soplata AE, McCarthy MM, Sherfey J, Lee S, Purdon PL, Brown EN, Kopell N. Thalamocortical control of propofol phase-amplitude coupling. PLoS Comput Biol. 2017 12; 13(12):e1005879. PMID: 29227992.
    Citations: 3     Fields:    Translation:Humans
  53. Kass RE, Amari SI, Arai K, Brown EN, Diekman CO, Diesmann M, Doiron B, Eden UT, Fairhall AL, Fiddyment GM, Fukai T, Grün S, Harrison MT, Helias M, Nakahara H, Teramae JN, Thomas PJ, Reimers M, Rodu J, Rotstein HG, Shea-Brown E, Shimazaki H, Shinomoto S, Yu BM, Kramer MA. Computational Neuroscience: Mathematical and Statistical Perspectives. Annu Rev Stat Appl. 2018 Mar; 5:183-214. PMID: 30976604.
    Citations: 1     
  54. Akeju O, Hobbs LE, Gao L, Burns SM, Pavone KJ, Plummer GS, Walsh EC, Houle TT, Kim SE, Bianchi MT, Ellenbogen JM, Brown EN. Dexmedetomidine promotes biomimetic non-rapid eye movement stage 3 sleep in humans: A pilot study. Clin Neurophysiol. 2018 01; 129(1):69-78. PMID: 29154132.
    Citations: 10     Fields:    Translation:Humans
  55. Lee JM, Akeju O, Terzakis K, Pavone KJ, Deng H, Houle TT, Firth PG, Shank ES, Brown EN, Purdon PL. A Prospective Study of Age-dependent Changes in Propofol-induced Electroencephalogram Oscillations in Children. Anesthesiology. 2017 08; 127(2):293-306. PMID: 28657957.
    Citations: 10     Fields:    Translation:Humans
  56. Flores FJ, Hartnack KE, Fath AB, Kim SE, Wilson MA, Brown EN, Purdon PL. Thalamocortical synchronization during induction and emergence from propofol-induced unconsciousness. Proc Natl Acad Sci U S A. 2017 08 08; 114(32):E6660-E6668. PMID: 28743752.
    Citations: 29     Fields:    Translation:Animals
  57. Guidera JA, Taylor NE, Lee JT, Vlasov KY, Pei J, Stephen EP, Mayo JP, Brown EN, Solt K. Sevoflurane Induces Coherent Slow-Delta Oscillations in Rats. Front Neural Circuits. 2017; 11:36. PMID: 28725184.
    Citations: 10     Fields:    Translation:Animals
  58. Faghih RT, Styer AK, Brown EN. Automated ovarian follicular monitoring: A novel real-time approach. Annu Int Conf IEEE Eng Med Biol Soc. 2017 Jul; 2017:632-635. PMID: 29059952.
    Citations:    Translation:Humans
  59. Purdon PL, Solt K, Sims NM, Brown EN, Westover MB. Design, implementation, and evaluation of a physiological closed-loop control device for medically-induced coma. Annu Int Conf IEEE Eng Med Biol Soc. 2017 Jul; 2017:4313-4316. PMID: 29060851.
    Citations:    Translation:Humans
  60. Song AH, Kucyi A, Napadow V, Brown EN, Loggia ML, Akeju O. Pharmacological Modulation of Noradrenergic Arousal Circuitry Disrupts Functional Connectivity of the Locus Ceruleus in Humans. J Neurosci. 2017 07 19; 37(29):6938-6945. PMID: 28626012.
    Citations: 24     Fields:    Translation:HumansCellsCTClinical Trials
  61. Pavone KJ, Su L, Gao L, Eromo E, Vazquez R, Rhee J, Hobbs LE, Ibala R, Demircioglu G, Purdon PL, Brown EN, Akeju O. Lack of Responsiveness during the Onset and Offset of Sevoflurane Anesthesia Is Associated with Decreased Awake-Alpha Oscillation Power. Front Syst Neurosci. 2017; 11:38. PMID: 28611601.
    Citations: 12     
  62. Akeju O, Brown EN. Neural oscillations demonstrate that general anesthesia and sedative states are neurophysiologically distinct from sleep. Curr Opin Neurobiol. 2017 06; 44:178-185. PMID: 28544930.
    Citations: 36     Fields:    Translation:HumansCells
  63. Bianciardi M, Strong C, Toschi N, Edlow BL, Fischl B, Brown EN, Rosen BR, Wald LL. A probabilistic template of human mesopontine tegmental nuclei from in vivo 7T MRI. Neuroimage. 2018 04 15; 170:222-230. PMID: 28476663.
    Citations: 9     Fields:    Translation:Humans
  64. Brown EN, Behrmann M. Controversy in statistical analysis of functional magnetic resonance imaging data. Proc Natl Acad Sci U S A. 2017 04 25; 114(17):E3368-E3369. PMID: 28420797.
    Citations: 11     Fields:    Translation:Humans
  65. Hashmi JA, Loggia ML, Khan S, Gao L, Kim J, Napadow V, Brown EN, Akeju O. Dexmedetomidine Disrupts the Local and Global Efficiencies of Large-scale Brain Networks. Anesthesiology. 2017 Mar; 126(3):419-430. PMID: 28092321.
    Citations: 16     Fields:    Translation:Humans
  66. Cusin C, Ionescu DF, Pavone KJ, Akeju O, Cassano P, Taylor N, Eikermann M, Durham K, Swee MB, Chang T, Dording C, Soskin D, Kelley J, Mischoulon D, Brown EN, Fava M. Ketamine augmentation for outpatients with treatment-resistant depression: Preliminary evidence for two-step intravenous dose escalation. Aust N Z J Psychiatry. 2017 Jan; 51(1):55-64. PMID: 26893373.
    Citations: 17     Fields:    Translation:Humans
  67. Miran S, Purdon PL, Brown EN, Babadi B. Robust Estimation of Sparse Narrowband Spectra from Neuronal Spiking Data. IEEE Trans Biomed Eng. 2017 10; 64(10):2462-2474. PMID: 28026746.
    Citations:    Fields:    Translation:HumansCells
  68. Iaccarino HF, Singer AC, Martorell AJ, Rudenko A, Gao F, Gillingham TZ, Mathys H, Seo J, Kritskiy O, Abdurrob F, Adaikkan C, Canter RG, Rueda R, Brown EN, Boyden ES, Tsai LH. Gamma frequency entrainment attenuates amyloid load and modifies microglia. Nature. 2016 12 07; 540(7632):230-235. PMID: 27929004.
    Citations: 169     Fields:    Translation:AnimalsCells
  69. Kenny JD, Chemali JJ, Cotten JF, Van Dort CJ, Kim SE, Ba D, Taylor NE, Brown EN, Solt K. Physostigmine and Methylphenidate Induce Distinct Arousal States During Isoflurane General Anesthesia in Rats. Anesth Analg. 2016 11; 123(5):1210-1219. PMID: 26991753.
    Citations: 13     Fields:    Translation:Animals
  70. Lee MA, Bakh N, Bisker G, Brown EN, Strano MS. A Pharmacokinetic Model of a Tissue Implantable Cortisol Sensor. Adv Healthc Mater. 2016 12; 5(23):3004-3015. PMID: 27782371.
    Citations: 2     Fields:    Translation:Humans
  71. Taylor NE, Van Dort CJ, Kenny JD, Pei J, Guidera JA, Vlasov KY, Lee JT, Boyden ES, Brown EN, Solt K. Optogenetic activation of dopamine neurons in the ventral tegmental area induces reanimation from general anesthesia. Proc Natl Acad Sci U S A. 2016 Nov 08; 113(45):12826-12831. PMID: 27791160.
    Citations: 54     Fields:    
  72. Akeju O, Kim SE, Vazquez R, Rhee J, Pavone KJ, Hobbs LE, Purdon PL, Brown EN. Spatiotemporal Dynamics of Dexmedetomidine-Induced Electroencephalogram Oscillations. PLoS One. 2016; 11(10):e0163431. PMID: 27711165.
    Citations: 23     Fields:    Translation:HumansCTClinical Trials
  73. Ishizawa Y, Ahmed OJ, Patel SR, Gale JT, Sierra-Mercado D, Brown EN, Eskandar EN. Dynamics of Propofol-Induced Loss of Consciousness Across Primate Neocortex. J Neurosci. 2016 07 20; 36(29):7718-26. PMID: 27445148.
    Citations: 21     Fields:    Translation:Animals
  74. Ionescu DF, Swee MB, Pavone KJ, Taylor N, Akeju O, Baer L, Nyer M, Cassano P, Mischoulon D, Alpert JE, Brown EN, Nock MK, Fava M, Cusin C. Rapid and Sustained Reductions in Current Suicidal Ideation Following Repeated Doses of Intravenous Ketamine: Secondary Analysis of an Open-Label Study. J Clin Psychiatry. 2016 06; 77(6):e719-25. PMID: 27232360.
    Citations: 21     Fields:    Translation:Humans
  75. Bianciardi M, Toschi N, Eichner C, Polimeni JR, Setsompop K, Brown EN, Hämäläinen MS, Rosen BR, Wald LL. In vivo functional connectome of human brainstem nuclei of the ascending arousal, autonomic, and motor systems by high spatial resolution 7-Tesla fMRI. MAGMA. 2016 Jun; 29(3):451-62. PMID: 27126248.
    Citations: 11     Fields:    Translation:HumansCells
  76. Akeju O, Song AH, Hamilos AE, Pavone KJ, Flores FJ, Brown EN, Purdon PL. Electroencephalogram signatures of ketamine anesthesia-induced unconsciousness. Clin Neurophysiol. 2016 06; 127(6):2414-22. PMID: 27178861.
    Citations: 28     Fields:    Translation:Humans
  77. Muindi F, Kenny JD, Taylor NE, Solt K, Wilson MA, Brown EN, Van Dort CJ. Electrical stimulation of the parabrachial nucleus induces reanimation from isoflurane general anesthesia. Behav Brain Res. 2016 06 01; 306:20-5. PMID: 26971629.
    Citations: 11     Fields:    Translation:Animals
  78. Akeju O, Hamilos AE, Song AH, Pavone KJ, Purdon PL, Brown EN. GABAA circuit mechanisms are associated with ether anesthesia-induced unconsciousness. Clin Neurophysiol. 2016 Jun; 127(6):2472-81. PMID: 27178867.
    Citations: 15     Fields:    Translation:Humans
  79. Lewis LD, Voigts J, Flores FJ, Schmitt LI, Wilson MA, Halassa MM, Brown EN. Thalamic reticular nucleus induces fast and local modulation of arousal state. Elife. 2015 Oct 13; 4:e08760. PMID: 26460547.
    Citations: 46     Fields:    Translation:Animals
  80. Purdon PL, Sampson A, Pavone KJ, Brown EN. Clinical Electroencephalography for Anesthesiologists: Part I: Background and Basic Signatures. Anesthesiology. 2015 Oct; 123(4):937-60. PMID: 26275092.
    Citations: 97     Fields:    Translation:Humans
  81. Purdon PL, Zhou DW, Akeju O, Brown EN. In reply. Anesthesiology. 2015 Sep; 123(3):725-8. PMID: 26284863.
    Citations: 1     Fields:    Translation:Humans
  82. Flores FJ, Ching S, Hartnack K, Fath AB, Purdon PL, Wilson MA, Brown EN. A PK-PD model of ketamine-induced high-frequency oscillations. J Neural Eng. 2015 Oct; 12(5):056006. PMID: 26268223.
    Citations: 4     Fields:    Translation:Animals
  83. Bianciardi M, Toschi N, Edlow BL, Eichner C, Setsompop K, Polimeni JR, Brown EN, Kinney HC, Rosen BR, Wald LL. Toward an In Vivo Neuroimaging Template of Human Brainstem Nuclei of the Ascending Arousal, Autonomic, and Motor Systems. Brain Connect. 2015 Dec; 5(10):597-607. PMID: 26066023.
    Citations: 17     Fields:    Translation:Humans
  84. Faghih RT, Dahleh MA, Brown EN. An optimization formulation for characterization of pulsatile cortisol secretion. Front Neurosci. 2015; 9:228. PMID: 26321898.
    Citations:    
  85. Faghih RT, Stokes PA, Marin MF, Zsido RG, Zorowitz S, Rosenbaum BL, Milad MR, Dougherty DD, Eskandar EN, Widge AS, Brown EN, Barbieri R. Characterization of fear conditioning and fear extinction by analysis of electrodermal activity. Annu Int Conf IEEE Eng Med Biol Soc. 2015 Aug; 2015:7814-8. PMID: 26738104.
    Citations: 2     Translation:Humans
  86. Kenny JD, Taylor NE, Brown EN, Solt K. Dextroamphetamine (but Not Atomoxetine) Induces Reanimation from General Anesthesia: Implications for the Roles of Dopamine and Norepinephrine in Active Emergence. PLoS One. 2015; 10(7):e0131914. PMID: 26148114.
    Citations: 21     Fields:    Translation:Animals
  87. Krishnaswamy P, Bonmassar G, Poulsen C, Pierce ET, Purdon PL, Brown EN. Reference-free removal of EEG-fMRI ballistocardiogram artifacts with harmonic regression. Neuroimage. 2016 Mar; 128:398-412. PMID: 26151100.
    Citations: 8     Fields:    Translation:Humans
  88. Purdon PL, Pavone KJ, Akeju O, Smith AC, Sampson AL, Lee J, Zhou DW, Solt K, Brown EN. The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia. Br J Anaesth. 2015 Jul; 115 Suppl 1:i46-i57. PMID: 26174300.
    Citations: 52     Fields:    Translation:Humans
  89. Van Dort CJ, Brown EN. Reply to Grace: Role of cholinergic neurons in rapid eye movement (REM) sleep control. Proc Natl Acad Sci U S A. 2015 Jul 21; 112(29):E3756. PMID: 26124152.
    Citations: 1     Fields:    Translation:AnimalsCells
  90. Cornelissen L, Kim SE, Purdon PL, Brown EN, Berde CB. Age-dependent electroencephalogram (EEG) patterns during sevoflurane general anesthesia in infants. Elife. 2015 Jun 23; 4:e06513. PMID: 26102526.
    Citations: 19     Fields:    Translation:Humans
  91. Pavone KJ, Akeju O, Sampson AL, Ling K, Purdon PL, Brown EN. Nitrous oxide-induced slow and delta oscillations. Clin Neurophysiol. 2016 Jan; 127(1):556-564. PMID: 26118489.
    Citations: 16     Fields:    Translation:Humans
  92. Westover MB, Kim SE, Ching S, Purdon PL, Brown EN. Robust control of burst suppression for medical coma. J Neural Eng. 2015 Aug; 12(4):046004. PMID: 26020243.
    Citations: 3     Fields:    Translation:Humans
  93. Czanner G, Sarma SV, Ba D, Eden UT, Wu W, Eskandar E, Lim HH, Temereanca S, Suzuki WA, Brown EN. Measuring the signal-to-noise ratio of a neuron. Proc Natl Acad Sci U S A. 2015 Jun 09; 112(23):7141-6. PMID: 25995363.
    Citations: 9     Fields:    Translation:AnimalsCells
  94. Jorgenson LA, Newsome WT, Anderson DJ, Bargmann CI, Brown EN, Deisseroth K, Donoghue JP, Hudson KL, Ling GS, MacLeish PR, Marder E, Normann RA, Sanes JR, Schnitzer MJ, Sejnowski TJ, Tank DW, Tsien RY, Ugurbil K, Wingfield JC. The BRAIN Initiative: developing technology to catalyse neuroscience discovery. Philos Trans R Soc Lond B Biol Sci. 2015 May 19; 370(1668). PMID: 25823863.
    Citations: 49     Fields:    Translation:Humans
  95. Faghih RT, Dahleh MA, Adler GK, Klerman EB, Brown EN. Quantifying Pituitary-Adrenal Dynamics and Deconvolution of Concurrent Cortisol and Adrenocorticotropic Hormone Data by Compressed Sensing. IEEE Trans Biomed Eng. 2015 Oct; 62(10):2379-88. PMID: 25935025.
    Citations: 3     Fields:    Translation:Humans
  96. Song W, Cajigas I, Brown EN, Giszter SF. Adaptation to elastic loads and BMI robot controls during rat locomotion examined with point-process GLMs. Front Syst Neurosci. 2015; 9:62. PMID: 25972789.
    Citations: 1     
  97. Westover MB, Ching S, Kumaraswamy VM, Akeju SO, Pierce E, Cash SS, Kilbride R, Brown EN, Purdon PL. The human burst suppression electroencephalogram of deep hypothermia. Clin Neurophysiol. 2015 Oct; 126(10):1901-1914. PMID: 25649968.
    Citations: 8     Fields:    Translation:Humans
  98. An J, Jonnalagadda D, Moura V, Purdon PL, Brown EN, Westover MB. Spatial variation in automated burst suppression detection in pharmacologically induced coma. Annu Int Conf IEEE Eng Med Biol Soc. 2015; 2015:7430-3. PMID: 26738009.
    Citations: 3     Translation:Humans
  99. Faghih RT, Barbieri R, Paulk AC, Asaad WF, Brown EN, Dougherty DD, Widge AS, Eskandar EN, Eden UT. Estimating a dynamic state to relate neural spiking activity to behavioral signals during cognitive tasks. Annu Int Conf IEEE Eng Med Biol Soc. 2015; 2015:7808-13. PMID: 26738103.
    Citations: 3     Translation:HumansAnimals
  100. Ghassemi MM, Amorim E, Pati SB, Mark RG, Brown EN, Purdon PL, Westover MB. An enhanced cerebral recovery index for coma prognostication following cardiac arrest. Annu Int Conf IEEE Eng Med Biol Soc. 2015; 2015:534-7. PMID: 26736317.
    Citations: 2     Translation:Humans
  101. Van Dort CJ, Zachs DP, Kenny JD, Zheng S, Goldblum RR, Gelwan NA, Ramos DM, Nolan MA, Wang K, Weng FJ, Lin Y, Wilson MA, Brown EN. Optogenetic activation of cholinergic neurons in the PPT or LDT induces REM sleep. Proc Natl Acad Sci U S A. 2015 Jan 13; 112(2):584-9. PMID: 25548191.
    Citations: 71     Fields:    Translation:AnimalsCells
  102. Kenny JD, Westover MB, Ching S, Brown EN, Solt K. Propofol and sevoflurane induce distinct burst suppression patterns in rats. Front Syst Neurosci. 2014; 8:237. PMID: 25565990.
    Citations: 19     
  103. Ba D, Babadi B, Purdon PL, Brown EN. Robust spectrotemporal decomposition by iteratively reweighted least squares. Proc Natl Acad Sci U S A. 2014 Dec 16; 111(50):E5336-45. PMID: 25468968.
    Citations: 5     Fields:    Translation:Humans
  104. Akeju O, Loggia ML, Catana C, Pavone KJ, Vazquez R, Rhee J, Contreras Ramirez V, Chonde DB, Izquierdo-Garcia D, Arabasz G, Hsu S, Habeeb K, Hooker JM, Napadow V, Brown EN, Purdon PL. Disruption of thalamic functional connectivity is a neural correlate of dexmedetomidine-induced unconsciousness. Elife. 2014 Nov 28; 3:e04499. PMID: 25432022.
    Citations: 44     Fields:    Translation:Humans
  105. Akeju O