Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Emery Neal Brown, Ph.D., M.D.

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Mentoring
Age-Dependent Effects of Propofol on Frontal Electroencephalogram Power
Summer, 06/05/14 - 08/22/14

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01MH115592 (MILLER, EARL K) Sep 8, 2017 - May 31, 2022
    NIH
    Thalamocortical Dynamics and Consciousness
    Role: Co-Principal Investigator
  2. R01AG056015 (PURDON, PATRICK L.) Apr 15, 2017 - Mar 31, 2022
    NIH
    The Aging Brain Under General Anesthesia: Neurophysiology, Neuroimaging Biomarkers of Aging and Alzheimer's Disease, and Post-Operative Cognitive Outcomes
    Role: Co-Principal Investigator
  3. P01GM118269 (BROWN, EMERY N.) Feb 10, 2017 - Jan 31, 2022
    NIH
    Integrated Systems Neuroscience Studies of Anaesthesia
    Role: Principal Investigator
  4. R01EB022726 (BROWN, EMERY N.) Sep 30, 2016 - Jun 30, 2020
    NIH
    Filtered Point Process Inference Framework for Modeling Neural Data
    Role: Principal Investigator
  5. U01FD005935 (COOPER, THOMAS) Sep 15, 2016 - Aug 31, 2021
    NIH
    A Public-Private Partnership to support the investigation of anesthesia-related neurotoxicity in the pediatric population through non-clinical and clinical studies.
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Qu JZ, Mueller A, McKay TB, Westover MB, Shelton KT, Shaefi S, D'Alessandro DA, Berra L, Brown EN, Houle TT, Akeju O. Nighttime dexmedetomidine for delirium prevention in non-mechanically ventilated patients after cardiac surgery (MINDDS): A single-centre, parallel-arm, randomised, placebo-controlled superiority trial. EClinicalMedicine. 2023 Feb; 56:101796. PMID: 36590787; PMCID: PMC9800196.
    Citations: 1     
  2. Chan D, Suk HJ, Jackson BL, Milman NP, Stark D, Klerman EB, Kitchener E, Fernandez Avalos VS, de Weck G, Banerjee A, Beach SD, Blanchard J, Stearns C, Boes AD, Uitermarkt B, Gander P, Howard M, Sternberg EJ, Nieto-Castanon A, Anteraper S, Whitfield-Gabrieli S, Brown EN, Boyden ES, Dickerson BC, Tsai LH. Gamma frequency sensory stimulation in mild probable Alzheimer's dementia patients: Results of feasibility and pilot studies. PLoS One. 2022; 17(12):e0278412. PMID: 36454969; PMCID: PMC9714926.
    Citations: 2     Fields:    Translation:Animals
  3. Wang W, Yuan RK, Mitchell JF, Zitting KM, St Hilaire MA, Wyatt JK, Scheer FAJL, Wright KP, Brown EN, Ronda JM, Klerman EB, Duffy JF, Dijk DJ, Czeisler CA. Desynchronizing the sleep---wake cycle from circadian timing to assess their separate contributions to physiology and behaviour and to estimate intrinsic circadian period. Nat Protoc. 2022 Nov 14. PMID: 36376588.
    Citations: 1     Fields:    
  4. Schiff ND, Brown EN. Protective down-regulated states in the human brain: A possible lesson from COVID-19. Proc Natl Acad Sci U S A. 2022 11 16; 119(46):e2120221119. PMID: 36343241; PMCID: PMC9674211.
    Citations: 1     Fields:    Translation:HumansPHPublic Health
  5. Subramanian S, Tseng B, Barbieri R, Brown EN. An unsupervised automated paradigm for artifact removal from electrodermal activity in an uncontrolled clinical setting. Physiol Meas. 2022 Nov 03; 43(11). PMID: 36113446.
    Citations:    Fields:    Translation:Humans
  6. Mashour GA, Pal D, Brown EN. Prefrontal cortex as a key node in arousal circuitry. Trends Neurosci. 2022 10; 45(10):722-732. PMID: 35995629; PMCID: PMC9492635.
    Citations: 1     Fields:    Translation:Humans
  7. Tseng B, Subramanian S, Barbieri R, Brown EN. Tonic Electrodermal Activity is a Robust Marker of Psychological and Physiological Changes during Induction of Anesthesia. Annu Int Conf IEEE Eng Med Biol Soc. 2022 07; 2022:418-421. PMID: 36086567.
    Citations:    Fields:    Translation:Humans
  8. Davis KC, Meschede-Krasa B, Cajigas I, Prins NW, Alver C, Gallo S, Bhatia S, Abel JH, Naeem JA, Fisher L, Raza F, Rifai WR, Morrison M, Ivan ME, Brown EN, Jagid JR, Prasad A. Design-development of an at-home modular brain-computer interface (BCI) platform in a case study of cervical spinal cord injury. J Neuroeng Rehabil. 2022 06 03; 19(1):53. PMID: 35659259; PMCID: PMC9166490.
    Citations:    Fields:    Translation:Humans
  9. Bhattacharya S, Donoghue JA, Mahnke M, Brincat SL, Brown EN, Miller EK. Propofol Anesthesia Alters Cortical Traveling Waves. J Cogn Neurosci. 2022 06 02; 34(7):1274-1286. PMID: 35468201.
    Citations:    Fields:    Translation:Animals
  10. Luppi AI, Cain J, Spindler LRB, Górska UJ, Toker D, Hudson AE, Brown EN, Diringer MN, Stevens RD, Massimini M, Monti MM, Stamatakis EA, Boly M. Correction: Mechanisms Underlying Disorders of Consciousness: Bridging Gaps to Move Toward an Integrated Translational Science. Neurocrit Care. 2022 Jun; 36(3):1080. PMID: 35359223; PMCID: PMC9110433.
    Citations:    Fields:    
  11. Adam EM, Brown EN, Kopell N, McCarthy MM. Deep brain stimulation in the subthalamic nucleus for Parkinson's disease can restore dynamics of striatal networks. Proc Natl Acad Sci U S A. 2022 05 10; 119(19):e2120808119. PMID: 35500112; PMCID: PMC9171607.
    Citations:    Fields:    Translation:Humans
  12. Waldrop G, Safavynia SA, Barra ME, Agarwal S, Berlin DA, Boehme AK, Brodie D, Choi JM, Doyle K, Fins JJ, Ganglberger W, Hoffman K, Mittel AM, Roh D, Mukerji SS, Der Nigoghossian C, Park S, Schenck EJ, Salazar-Schicchi J, Shen Q, Sholle E, Velazquez AG, Walline MC, Westover MB, Brown EN, Victor J, Edlow BL, Schiff ND, Claassen J. Prolonged Unconsciousness is Common in COVID-19 and Associated with Hypoxemia. Ann Neurol. 2022 06; 91(6):740-755. PMID: 35254675; PMCID: PMC9082460.
    Citations: 1     Fields:    Translation:Humans
  13. Barra ME, Edlow BL, Lund JT, DeSanctis KS, Vetrano J, Reilly-Tremblay C, Zhang ER, Bodien YG, Brown EN, Solt K. Stability of extemporaneously prepared preservative-free methylphenidate 5 mg/mL intravenous solution. Am J Health Syst Pharm. 2022 02 18; 79(5):359-363. PMID: 34788364; PMCID: PMC9013207.
    Citations:    Fields:    Translation:Humans
  14. Schamberg G, Badgeley M, Meschede-Krasa B, Kwon O, Brown EN. Continuous action deep reinforcement learning for propofol dosing during general anesthesia. Artif Intell Med. 2022 01; 123:102227. PMID: 34998516.
    Citations: 1     Fields:    Translation:Humans
  15. Koch S, Windmann V, Chakravarty S, Kruppa J, Yürek F, Brown EN, Winterer G, Spies C. Perioperative Electroencephalogram Spectral Dynamics Related to Postoperative Delirium in Older Patients. Anesth Analg. 2021 12 01; 133(6):1598-1607. PMID: 34591807.
    Citations: 1     Fields:    Translation:Humans
  16. Subramanian S, Tseng B, Barbieri R, Brown EN. Unsupervised Machine Learning Methods for Artifact Removal in Electrodermal Activity. Annu Int Conf IEEE Eng Med Biol Soc. 2021 11; 2021:399-402. PMID: 34891318.
    Citations:    Fields:    Translation:Humans
  17. Cajigas I, Davis KC, Meschede-Krasa B, Prins NW, Gallo S, Naeem JA, Palermo A, Wilson A, Guerra S, Parks BA, Zimmerman L, Gant K, Levi AD, Dietrich WD, Fisher L, Vanni S, Tauber JM, Garwood IC, Abel JH, Brown EN, Ivan ME, Prasad A, Jagid J. Implantable brain-computer interface for neuroprosthetic-enabled volitional hand grasp restoration in spinal cord injury. Brain Commun. 2021; 3(4):fcab248. PMID: 34870202; PMCID: PMC8637800.
    Citations: 4     
  18. Shanker A, Abel JH, Narayanan S, Mathur P, Work E, Schamberg G, Sharkey A, Bose R, Rangasamy V, Senthilnathan V, Brown EN, Subramaniam B. Perioperative Multimodal General Anesthesia Focusing on Specific CNS Targets in Patients Undergoing Cardiac Surgeries: The Pathfinder Feasibility Trial. Front Med (Lausanne). 2021; 8:719512. PMID: 34722563; PMCID: PMC8551571.
    Citations:    
  19. Subramanian S, Purdon PL, Barbieri R, Brown EN. A Model-Based Framework for Assessing the Physiologic Structure of Electrodermal Activity. IEEE Trans Biomed Eng. 2021 09; 68(9):2833-2845. PMID: 33822719.
    Citations: 2     Fields:    Translation:Humans
  20. Le Mau T, Hoemann K, Lyons SH, Fugate JMB, Brown EN, Gendron M, Barrett LF. Professional actors demonstrate variability, not stereotypical expressions, when portraying emotional states in photographs. Nat Commun. 2021 08 19; 12(1):5037. PMID: 34413313.
    Citations: 1     Fields:    Translation:Humans
  21. Garwood IC, Chakravarty S, Donoghue J, Mahnke M, Kahali P, Chamadia S, Akeju O, Miller EK, Brown EN. A hidden Markov model reliably characterizes ketamine-induced spectral dynamics in macaque local field potentials and human electroencephalograms. PLoS Comput Biol. 2021 08; 17(8):e1009280. PMID: 34407069.
    Citations: 2     Fields:    Translation:HumansAnimals
  22. Subramanian S, Purdon PL, Barbieri R, Brown EN. Quantitative assessment of the relationship between behavioral and autonomic dynamics during propofol-induced unconsciousness. PLoS One. 2021; 16(8):e0254053. PMID: 34379623.
    Citations: 1     Fields:    Translation:HumansCTClinical Trials
  23. Luppi AI, Cain J, Spindler LRB, Górska UJ, Toker D, Hudson AE, Brown EN, Diringer MN, Stevens RD, Massimini M, Monti MM, Stamatakis EA, Boly M. Mechanisms Underlying Disorders of Consciousness: Bridging Gaps to Move Toward an Integrated Translational Science. Neurocrit Care. 2021 07; 35(Suppl 1):37-54. PMID: 34236622; PMCID: PMC8266690.
    Citations: 6     Fields:    Translation:Humans
  24. Subramanian S, Purdon PL, Barbieri R, Brown EN. Elementary integrate-and-fire process underlies pulse amplitudes in Electrodermal activity. PLoS Comput Biol. 2021 07; 17(7):e1009099. PMID: 34232965; PMCID: PMC8289084.
    Citations:    Fields:    Translation:Humans
  25. Shanker A, Abel JH, Schamberg G, Brown EN. Etiology of Burst Suppression EEG Patterns. Front Psychol. 2021; 12:673529. PMID: 34177731.
    Citations: 1     
  26. Schamberg G, Brown EN. The Drug Titration Paradox is Simpson's Paradox. Clin Pharmacol Ther. 2021 12; 110(6):1424-1425. PMID: 34038588.
    Citations:    Fields:    Translation:Humans
  27. Abel JH, Badgeley MA, Meschede-Krasa B, Schamberg G, Garwood IC, Lecamwasam K, Chakravarty S, Zhou DW, Keating M, Purdon PL, Brown EN. Machine learning of EEG spectra classifies unconsciousness during GABAergic anesthesia. PLoS One. 2021; 16(5):e0246165. PMID: 33956800.
    Citations: 1     Fields:    Translation:Humans
  28. Bastos AM, Donoghue JA, Brincat SL, Mahnke M, Yanar J, Correa J, Waite AS, Lundqvist M, Roy J, Brown EN, Miller EK. Neural effects of propofol-induced unconsciousness and its reversal using thalamic stimulation. Elife. 2021 04 27; 10. PMID: 33904411.
    Citations: 13     Fields:    Translation:Animals
  29. Abel JH, Badgeley MA, Baum TE, Chakravarty S, Purdon PL, Brown EN. Constructing a control-ready model of EEG signal during general anesthesia in humans. Proc IFAC World Congress. 2020; 53(2):15870-15876. PMID: 34184002.
    Citations:    
  30. Chakravarty S, Waite AS, Abel JH, Brown EN. A simulation-based comparative analysis of PID and LQG control for closed-loop anesthesia delivery. Proc IFAC World Congress. 2020; 53(2):15898-15903. PMID: 34184003.
    Citations:    
  31. Guay CS, Labonte AK, Montana MC, Landsness EC, Lucey BP, Kafashan M, Haroutounian S, Avidan MS, Brown EN, Palanca BJA. Closed-Loop Acoustic Stimulation During Sedation with Dexmedetomidine (CLASS-D): Protocol for a Within-Subject, Crossover, Controlled, Interventional Trial with Healthy Volunteers. Nat Sci Sleep. 2021; 13:303-313. PMID: 33692642; PMCID: PMC7939493.
    Citations:    
  32. Casile A, Faghih RT, Brown EN. Robust point-process Granger causality analysis in presence of exogenous temporal modulations and trial-by-trial variability in spike trains. PLoS Comput Biol. 2021 01; 17(1):e1007675. PMID: 33493162.
    Citations:    Fields:    Translation:AnimalsCells
  33. Conklin J, Frosch MP, Mukerji SS, Rapalino O, Maher MD, Schaefer PW, Lev MH, Gonzalez RG, Das S, Champion SN, Magdamo C, Sen P, Harrold GK, Alabsi H, Normandin E, Shaw B, Lemieux JE, Sabeti PC, Branda JA, Brown EN, Westover MB, Huang SY, Edlow BL. Susceptibility-weighted imaging reveals cerebral microvascular injury in severe COVID-19. J Neurol Sci. 2021 02 15; 421:117308. PMID: 33497950.
    Citations: 23     Fields:    Translation:HumansCTClinical Trials
  34. Edlow BL, Claassen J, Victor JD, Brown EN, Schiff ND. Delayed reemergence of consciousness in survivors of severe COVID-19. Neurocrit Care. 2020 12; 33(3):627-629. PMID: 33174149; PMCID: PMC7654564.
    Citations: 6     Fields:    Translation:HumansCells
  35. Shao YR, Kahali P, Houle TT, Deng H, Colvin C, Dickerson BC, Brown EN, Purdon PL. Low Frontal Alpha Power Is Associated With the Propensity for Burst Suppression: An Electroencephalogram Phenotype for a "Vulnerable Brain". Anesth Analg. 2020 11; 131(5):1529-1539. PMID: 33079876; PMCID: PMC7553194.
    Citations: 9     Fields:    Translation:Humans
  36. Subramanian S, Barbieri R, Brown EN. Point process temporal structure characterizes electrodermal activity. Proc Natl Acad Sci U S A. 2020 10 20; 117(42):26422-26428. PMID: 33008878.
    Citations: 3     Fields:    Translation:Humans
  37. Edlow BL, Barra ME, Zhou DW, Foulkes AS, Snider SB, Threlkeld ZD, Chakravarty S, Kirsch JE, Chan ST, Meisler SL, Bleck TP, Fins JJ, Giacino JT, Hochberg LR, Solt K, Brown EN, Bodien YG. Personalized Connectome Mapping to Guide Targeted Therapy and Promote Recovery of Consciousness in the Intensive Care Unit. Neurocrit Care. 2020 10; 33(2):364-375. PMID: 32794142; PMCID: PMC8336723.
    Citations: 14     Fields:    Translation:HumansCTClinical Trials
  38. Stephen EP, Hotan GC, Pierce ET, Harrell PG, Walsh JL, Brown EN, Purdon PL. Broadband slow-wave modulation in posterior and anterior cortex tracks distinct states of propofol-induced unconsciousness. Sci Rep. 2020 08 13; 10(1):13701. PMID: 32792556.
    Citations: 2     Fields:    Translation:Humans
  39. Conklin J, Frosch MP, Mukerji S, Rapalino O, Maher M, Schaefer PW, Lev MH, Gonzalez RG, Das S, Champion SN, Magdamo C, Sen P, Harrold GK, Alabsi H, Normandin E, Shaw B, Lemieux J, Sabeti P, Branda JA, Brown EN, Westover MB, Huang SY, Edlow BL. Cerebral Microvascular Injury in Severe COVID-19. medRxiv. 2020 Jul 24. PMID: 32743599; PMCID: PMC7386523.
    Citations:    
  40. Subramanian S, Barbieri R, Purdon PL, Brown EN. Detecting Loss and Regain of Consciousness during Propofol Anesthesia using Multimodal Indices of Autonomic State. Annu Int Conf IEEE Eng Med Biol Soc. 2020 07; 2020:824-827. PMID: 33018112.
    Citations: 2     Fields:    Translation:Humans
  41. Shao YR, Kahali P, Houle TT, Deng H, Colvin C, Dickerson BC, Brown EN, Purdon PL. Low Frontal Alpha Power Is Associated With the Propensity for Burst Suppression: An Electroencephalogram Phenotype for a "Vulnerable Brain". Anesth Analg. 2020 May 14. PMID: 32427658.
    Citations:    Fields:    
  42. Chakravarty S, Threlkeld ZD, Bodien YG, Edlow BL, Brown EN. A state-space model for dynamic functional connectivity. Conf Rec Asilomar Conf Signals Syst Comput. 2019 Nov; 2019:240-244. PMID: 32801606.
    Citations:    
  43. Koroshetz WJ, Behrman S, Brame CJ, Branchaw JL, Brown EN, Clark EA, Dockterman D, Elm JJ, Gay PL, Green KM, Hsi S, Kaplitt MG, Kolber BJ, Kolodkin AL, Lipscombe D, MacLeod MR, McKinney CC, Munafò MR, Oakley B, Olimpo JT, Percie du Sert N, Raman IM, Riley C, Shelton AL, Uzzo SM, Crawford DC, Silberberg SD. Framework for advancing rigorous research. Elife. 2020 03 04; 9. PMID: 32127131; PMCID: PMC7056268.
    Citations: 5     Fields:    Translation:Humans
  44. Chamadia S, Pedemonte JC, Hahm EY, Mekonnen J, Ibala R, Gitlin J, Ethridge BR, Qu J, Vazquez R, Rhee J, Liao ET, Brown EN, Akeju O. Delta oscillations phase limit neural activity during sevoflurane anesthesia. Commun Biol. 2019 Nov 15; 2(1):415. PMID: 31925268.
    Citations:    
  45. Chamadia S, Pedemonte JC, Hahm EY, Mekonnen J, Ibala R, Gitlin J, Ethridge BR, Qu J, Vazquez R, Rhee J, Liao ET, Brown EN, Akeju O. Delta oscillations phase limit neural activity during sevoflurane anesthesia. Commun Biol. 2019; 2:415. PMID: 31754645; PMCID: PMC6858348.
    Citations: 10     Translation:HumansCells
  46. Agrawal U, Brown EN, Lewis LD. Model-based physiological noise removal in fast fMRI. Neuroimage. 2020 01 15; 205:116231. PMID: 31589991.
    Citations: 8     Fields:    Translation:Humans
  47. Koch S, Feinkohl I, Chakravarty S, Windmann V, Lichtner G, Pischon T, Brown EN, Spies C. Cognitive Impairment Is Associated with Absolute Intraoperative Frontal a-Band Power but Not with Baseline a-Band Power: A Pilot Study. Dement Geriatr Cogn Disord. 2019; 48(1-2):83-92. PMID: 31578031.
    Citations: 5     Fields:    Translation:Humans
  48. Brown EN. Neurologic Examination for Anesthesiologists: Reply. Anesthesiology. 2019 10; 131(4):946. PMID: 31436546.
    Citations:    Fields:    Translation: