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profileEmery Neal Brown, Ph.D., M.D.

TitleWarren M. Zapol Professor of Anaesthesia
InstitutionMassachusetts General Hospital
DepartmentAnaesthesia
AddressMassachusetts General Hospital
Anesthesia & Critical Care, Clinics 3
55 Fruit St
Boston MA 02114
Phone617/726-8786
Fax617/726-8410
vCardDownload vCard (login for email)

Collapse Mentoring 
Collapse completed student projects
Age-Dependent Effects of Propofol on Frontal Electroencephalogram Power
Summer, 06/05/14 - 08/22/14

Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01MH115592     (MILLER, EARL K)Sep 8, 2017 - May 31, 2022
NIH/NIMH
Thalamocortical Dynamics and Consciousness
Role: Co-Principal Investigator

R01AG056015     (PURDON, PATRICK L.)Apr 15, 2017 - Mar 31, 2022
NIH/NIA
The Aging Brain Under General Anesthesia: Neurophysiology, Neuroimaging Biomarkers of Aging and Alzheimer's Disease, and Post-Operative Cognitive Outcomes
Role: Co-Principal Investigator

P01GM118269     (BROWN, EMERY N.)Feb 10, 2017 - Jan 31, 2022
NIH/NIGMS
Integrated Systems Neuroscience Studies of Anaesthesia
Role: Principal Investigator

R01EB022726     (BROWN, EMERY N.)Sep 30, 2016 - Jun 30, 2019
NIH/NIBIB
Filtered Point Process Inference Framework for Modeling Neural Data
Role: Principal Investigator

U01FD005935     (COOPER, THOMAS)Sep 15, 2016 - Aug 31, 2021
FDA
A Public-Private Partnership to support the investigation of anesthesia-related neurotoxicity in the pediatric population through non-clinical and clinical studies.
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Akeju O, Hobbs LE, Gao L, Burns SM, Pavone KJ, Plummer GS, Walsh EC, Houle TT, Kim SE, Bianchi MT, Ellenbogen JM, Brown EN. Dexmedetomidine promotes biomimetic non-rapid eye movement stage 3 sleep in humans: A pilot study. Clin Neurophysiol. 2017 Oct 20; 129(1):69-78. PMID: 29154132.
    View in: PubMed
  2. Lee JM, Akeju O, Terzakis K, Pavone KJ, Deng H, Houle TT, Firth PG, Shank ES, Brown EN, Purdon PL. A Prospective Study of Age-dependent Changes in Propofol-induced Electroencephalogram Oscillations in Children. Anesthesiology. 2017 Aug; 127(2):293-306. PMID: 28657957.
    View in: PubMed
  3. Flores FJ, Hartnack KE, Fath AB, Kim SE, Wilson MA, Brown EN, Purdon PL. Thalamocortical synchronization during induction and emergence from propofol-induced unconsciousness. Proc Natl Acad Sci U S A. 2017 Aug 08; 114(32):E6660-E6668. PMID: 28743752.
    View in: PubMed
  4. Faghih RT, Styer AK, Brown EN. Automated ovarian follicular monitoring: A novel real-time approach. Conf Proc IEEE Eng Med Biol Soc. 2017 Jul; 2017:632-635. PMID: 29059952.
    View in: PubMed
  5. Purdon PL, Solt K, Sims NM, Brown EN, Westover MB. Design, implementation, and evaluation of a physiological closed-loop control device for medically-induced coma. Conf Proc IEEE Eng Med Biol Soc. 2017 Jul; 2017:4313-4316. PMID: 29060851.
    View in: PubMed
  6. Song AH, Kucyi A, Napadow V, Brown EN, Loggia ML, Akeju O. Pharmacological Modulation of Noradrenergic Arousal Circuitry Disrupts Functional Connectivity of the Locus Ceruleus in Humans. J Neurosci. 2017 Jul 19; 37(29):6938-6945. PMID: 28626012.
    View in: PubMed
  7. Pavone KJ, Su L, Gao L, Eromo E, Vazquez R, Rhee J, Hobbs LE, Ibala R, Demircioglu G, Purdon PL, Brown EN, Akeju O. Lack of Responsiveness during the Onset and Offset of Sevoflurane Anesthesia Is Associated with Decreased Awake-Alpha Oscillation Power. Front Syst Neurosci. 2017; 11:38. PMID: 28611601.
    View in: PubMed
  8. Akeju O, Brown EN. Neural oscillations demonstrate that general anesthesia and sedative states are neurophysiologically distinct from sleep. Curr Opin Neurobiol. 2017 Jun; 44:178-185. PMID: 28544930.
    View in: PubMed
  9. Bianciardi M, Strong C, Toschi N, Edlow BL, Fischl B, Brown EN, Rosen BR, Wald LL. A probabilistic template of human mesopontine tegmental nuclei from in vivo 7T MRI. Neuroimage. 2017 May 03. PMID: 28476663.
    View in: PubMed
  10. Brown EN, Behrmann M. Controversy in statistical analysis of functional magnetic resonance imaging data. Proc Natl Acad Sci U S A. 2017 Apr 25; 114(17):E3368-E3369. PMID: 28420797.
    View in: PubMed
  11. Hashmi JA, Loggia ML, Khan S, Gao L, Kim J, Napadow V, Brown EN, Akeju O. Dexmedetomidine Disrupts the Local and Global Efficiencies of Large-scale Brain Networks. Anesthesiology. 2017 Mar; 126(3):419-430. PMID: 28092321.
    View in: PubMed
  12. Cusin C, Ionescu DF, Pavone KJ, Akeju O, Cassano P, Taylor N, Eikermann M, Durham K, Swee MB, Chang T, Dording C, Soskin D, Kelley J, Mischoulon D, Brown EN, Fava M. Ketamine augmentation for outpatients with treatment-resistant depression: Preliminary evidence for two-step intravenous dose escalation. Aust N Z J Psychiatry. 2017 Jan; 51(1):55-64. PMID: 26893373.
    View in: PubMed
  13. Miran S, Purdon PL, Brown EN, Babadi B. Robust Estimation of Sparse Narrowband Spectra from Neuronal Spiking Data. IEEE Trans Biomed Eng. 2017 Oct; 64(10):2462-2474. PMID: 28026746.
    View in: PubMed
  14. Iaccarino HF, Singer AC, Martorell AJ, Rudenko A, Gao F, Gillingham TZ, Mathys H, Seo J, Kritskiy O, Abdurrob F, Adaikkan C, Canter RG, Rueda R, Brown EN, Boyden ES, Tsai LH. Gamma frequency entrainment attenuates amyloid load and modifies microglia. Nature. 2016 12 07; 540(7632):230-235. PMID: 27929004.
    View in: PubMed
  15. Kenny JD, Chemali JJ, Cotten JF, Van Dort CJ, Kim SE, Ba D, Taylor NE, Brown EN, Solt K. Physostigmine and Methylphenidate Induce Distinct Arousal States During Isoflurane General Anesthesia in Rats. Anesth Analg. 2016 Nov; 123(5):1210-1219. PMID: 26991753.
    View in: PubMed
  16. Lee MA, Bakh N, Bisker G, Brown EN, Strano MS. A Pharmacokinetic Model of a Tissue Implantable Cortisol Sensor. Adv Healthc Mater. 2016 Dec; 5(23):3004-3015. PMID: 27782371.
    View in: PubMed
  17. Taylor NE, Van Dort CJ, Kenny JD, Pei J, Guidera JA, Vlasov KY, Lee JT, Boyden ES, Brown EN, Solt K. Optogenetic activation of dopamine neurons in the ventral tegmental area induces reanimation from general anesthesia. Proc Natl Acad Sci U S A. 2016 Oct 24. PMID: 27791160.
    View in: PubMed
  18. Akeju O, Kim SE, Vazquez R, Rhee J, Pavone KJ, Hobbs LE, Purdon PL, Brown EN. Spatiotemporal Dynamics of Dexmedetomidine-Induced Electroencephalogram Oscillations. PLoS One. 2016; 11(10):e0163431. PMID: 27711165.
    View in: PubMed
  19. Ishizawa Y, Ahmed OJ, Patel SR, Gale JT, Sierra-Mercado D, Brown EN, Eskandar EN. Dynamics of Propofol-Induced Loss of Consciousness Across Primate Neocortex. J Neurosci. 2016 Jul 20; 36(29):7718-26. PMID: 27445148; PMCID: PMC4951576 [Available on 01/20/17].
  20. Ionescu DF, Swee MB, Pavone KJ, Taylor N, Akeju O, Baer L, Nyer M, Cassano P, Mischoulon D, Alpert JE, Brown EN, Nock MK, Fava M, Cusin C. Rapid and Sustained Reductions in Current Suicidal Ideation Following Repeated Doses of Intravenous Ketamine: Secondary Analysis of an Open-Label Study. J Clin Psychiatry. 2016 Jun; 77(6):e719-25. PMID: 27232360.
    View in: PubMed
  21. Bianciardi M, Toschi N, Eichner C, Polimeni JR, Setsompop K, Brown EN, Hämäläinen MS, Rosen BR, Wald LL. In vivo functional connectome of human brainstem nuclei of the ascending arousal, autonomic, and motor systems by high spatial resolution 7-Tesla fMRI. MAGMA. 2016 Jun; 29(3):451-62. PMID: 27126248; PMCID: PMC4892960.
  22. Akeju O, Song AH, Hamilos AE, Pavone KJ, Flores FJ, Brown EN, Purdon PL. Electroencephalogram signatures of ketamine anesthesia-induced unconsciousness. Clin Neurophysiol. 2016 06; 127(6):2414-22. PMID: 27178861; PMCID: PMC4871620 [Available on 06/01/17].
  23. Muindi F, Kenny JD, Taylor NE, Solt K, Wilson MA, Brown EN, Van Dort CJ. Electrical stimulation of the parabrachial nucleus induces reanimation from isoflurane general anesthesia. Behav Brain Res. 2016 06 01; 306:20-5. PMID: 26971629.
    View in: PubMed
  24. Akeju O, Hamilos AE, Song AH, Pavone KJ, Purdon PL, Brown EN. GABAA circuit mechanisms are associated with ether anesthesia-induced unconsciousness. Clin Neurophysiol. 2016 Jun; 127(6):2472-81. PMID: 27178867; PMCID: PMC4869993 [Available on 06/01/17].
  25. Lewis LD, Voigts J, Flores FJ, Schmitt LI, Wilson MA, Halassa MM, Brown EN. Thalamic reticular nucleus induces fast and local modulation of arousal state. Elife. 2015 Oct 13; 4:e08760. PMID: 26460547; PMCID: PMC4686423.
  26. Purdon PL, Sampson A, Pavone KJ, Brown EN. Clinical Electroencephalography for Anesthesiologists: Part I: Background and Basic Signatures. Anesthesiology. 2015 Oct; 123(4):937-60. PMID: 26275092; PMCID: PMC4573341.
  27. Purdon PL, Zhou DW, Akeju O, Brown EN. In reply. Anesthesiology. 2015 Sep; 123(3):725-8. PMID: 26284863; PMCID: PMC4625800.
  28. Flores FJ, Ching S, Hartnack K, Fath AB, Purdon PL, Wilson MA, Brown EN. A PK-PD model of ketamine-induced high-frequency oscillations. J Neural Eng. 2015 Oct; 12(5):056006. PMID: 26268223.
    View in: PubMed
  29. Bianciardi M, Toschi N, Edlow BL, Eichner C, Setsompop K, Polimeni JR, Brown EN, Kinney HC, Rosen BR, Wald LL. Toward an In Vivo Neuroimaging Template of Human Brainstem Nuclei of the Ascending Arousal, Autonomic, and Motor Systems. Brain Connect. 2015 Dec; 5(10):597-607. PMID: 26066023; PMCID: PMC4684653 [Available on 12/01/16].
  30. Faghih RT, Dahleh MA, Brown EN. An optimization formulation for characterization of pulsatile cortisol secretion. Front Neurosci. 2015; 9:228. PMID: 26321898; PMCID: PMC4531247.
  31. Faghih RT, Stokes PA, Marin MF, Zsido RG, Zorowitz S, Rosenbaum BL, Milad MR, Dougherty DD, Eskandar EN, Widge AS, Brown EN, Barbieri R. Characterization of fear conditioning and fear extinction by analysis of electrodermal activity. Conf Proc IEEE Eng Med Biol Soc. 2015 Aug; 2015:7814-8. PMID: 26738104.
    View in: PubMed
  32. Kenny JD, Taylor NE, Brown EN, Solt K. Dextroamphetamine (but Not Atomoxetine) Induces Reanimation from General Anesthesia: Implications for the Roles of Dopamine and Norepinephrine in Active Emergence. PLoS One. 2015; 10(7):e0131914. PMID: 26148114; PMCID: PMC4492624.
  33. Krishnaswamy P, Bonmassar G, Poulsen C, Pierce ET, Purdon PL, Brown EN. Reference-free removal of EEG-fMRI ballistocardiogram artifacts with harmonic regression. Neuroimage. 2016 Mar; 128:398-412. PMID: 26151100; PMCID: PMC4761527 [Available on 03/01/17].
  34. Purdon PL, Pavone KJ, Akeju O, Smith AC, Sampson AL, Lee J, Zhou DW, Solt K, Brown EN. The Ageing Brain: Age-dependent changes in the electroencephalogram during propofol and sevoflurane general anaesthesia. Br J Anaesth. 2015 Jul; 115 Suppl 1:i46-i57. PMID: 26174300; PMCID: PMC4501918.
  35. Van Dort CJ, Brown EN. Reply to Grace: Role of cholinergic neurons in rapid eye movement (REM) sleep control. Proc Natl Acad Sci U S A. 2015 Jul 21; 112(29):E3756. PMID: 26124152; PMCID: PMC4517216.
  36. Cornelissen L, Kim SE, Purdon PL, Brown EN, Berde CB. Age-dependent electroencephalogram (EEG) patterns during sevoflurane general anesthesia in infants. Elife. 2015 Jun 23; 4:e06513. PMID: 26102526; PMCID: PMC4502759.
  37. Pavone KJ, Akeju O, Sampson AL, Ling K, Purdon PL, Brown EN. Nitrous oxide-induced slow and delta oscillations. Clin Neurophysiol. 2016 Jan; 127(1):556-564. PMID: 26118489; PMCID: PMC4675698 [Available on 01/01/17].
  38. Westover MB, Kim SE, Ching S, Purdon PL, Brown EN. Robust control of burst suppression for medical coma. J Neural Eng. 2015 Aug; 12(4):046004. PMID: 26020243; PMCID: PMC4517835.
  39. Czanner G, Sarma SV, Ba D, Eden UT, Wu W, Eskandar E, Lim HH, Temereanca S, Suzuki WA, Brown EN. Measuring the signal-to-noise ratio of a neuron. Proc Natl Acad Sci U S A. 2015 Jun 09; 112(23):7141-6. PMID: 25995363; PMCID: PMC4466709.
  40. Jorgenson LA, Newsome WT, Anderson DJ, Bargmann CI, Brown EN, Deisseroth K, Donoghue JP, Hudson KL, Ling GS, MacLeish PR, Marder E, Normann RA, Sanes JR, Schnitzer MJ, Sejnowski TJ, Tank DW, Tsien RY, Ugurbil K, Wingfield JC. The BRAIN Initiative: developing technology to catalyse neuroscience discovery. Philos Trans R Soc Lond B Biol Sci. 2015 May 19; 370(1668). PMID: 25823863; PMCID: PMC4387507.
  41. Faghih RT, Dahleh MA, Adler GK, Klerman EB, Brown EN. Quantifying Pituitary-Adrenal Dynamics and Deconvolution of Concurrent Cortisol and Adrenocorticotropic Hormone Data by Compressed Sensing. IEEE Trans Biomed Eng. 2015 Oct; 62(10):2379-88. PMID: 25935025; PMCID: PMC4579049 [Available on 10/01/16].
  42. Song W, Cajigas I, Brown EN, Giszter SF. Adaptation to elastic loads and BMI robot controls during rat locomotion examined with point-process GLMs. Front Syst Neurosci. 2015; 9:62. PMID: 25972789; PMCID: PMC4411868.
  43. Westover MB, Ching S, Kumaraswamy VM, Akeju SO, Pierce E, Cash SS, Kilbride R, Brown EN, Purdon PL. The human burst suppression electroencephalogram of deep hypothermia. Clin Neurophysiol. 2015 Oct; 126(10):1901-1914. PMID: 25649968; PMCID: PMC4504839 [Available on 10/01/16].
  44. An J, Jonnalagadda D, Moura V, Purdon PL, Brown EN, Westover MB. Spatial variation in automated burst suppression detection in pharmacologically induced coma. Conf Proc IEEE Eng Med Biol Soc. 2015; 2015:7430-3. PMID: 26738009; PMCID: PMC4876722.
  45. Faghih RT, Barbieri R, Paulk AC, Asaad WF, Brown EN, Dougherty DD, Widge AS, Eskandar EN, Eden UT. Estimating a dynamic state to relate neural spiking activity to behavioral signals during cognitive tasks. Conf Proc IEEE Eng Med Biol Soc. 2015; 2015:7808-13. PMID: 26738103.
    View in: PubMed
  46. Ghassemi MM, Amorim E, Pati SB, Mark RG, Brown EN, Purdon PL, Westover MB. An enhanced cerebral recovery index for coma prognostication following cardiac arrest. Conf Proc IEEE Eng Med Biol Soc. 2015; 2015:534-7. PMID: 26736317; PMCID: PMC4870018.
  47. Van Dort CJ, Zachs DP, Kenny JD, Zheng S, Goldblum RR, Gelwan NA, Ramos DM, Nolan MA, Wang K, Weng FJ, Lin Y, Wilson MA, Brown EN. Optogenetic activation of cholinergic neurons in the PPT or LDT induces REM sleep. Proc Natl Acad Sci U S A. 2015 Jan 13; 112(2):584-9. PMID: 25548191; PMCID: PMC4299243.
  48. Kenny JD, Westover MB, Ching S, Brown EN, Solt K. Propofol and sevoflurane induce distinct burst suppression patterns in rats. Front Syst Neurosci. 2014; 8:237. PMID: 25565990; PMCID: PMC4270179.
  49. Ba D, Babadi B, Purdon PL, Brown EN. Robust spectrotemporal decomposition by iteratively reweighted least squares. Proc Natl Acad Sci U S A. 2014 Dec 16; 111(50):E5336-45. PMID: 25468968; PMCID: PMC4273341.
  50. Akeju O, Loggia ML, Catana C, Pavone KJ, Vazquez R, Rhee J, Contreras Ramirez V, Chonde DB, Izquierdo-Garcia D, Arabasz G, Hsu S, Habeeb K, Hooker JM, Napadow V, Brown EN, Purdon PL. Disruption of thalamic functional connectivity is a neural correlate of dexmedetomidine-induced unconsciousness. Elife. 2014 Nov 28; 3:e04499. PMID: 25432022; PMCID: PMC4280551.
  51. Akeju O, Pavone KJ, Westover MB, Vazquez R, Prerau MJ, Harrell PG, Hartnack KE, Rhee J, Sampson AL, Habeeb K, Gao L, Lei G, Pierce ET, Walsh JL, Brown EN, Purdon PL. A comparison of propofol- and dexmedetomidine-induced electroencephalogram dynamics using spectral and coherence analysis. Anesthesiology. 2014 Nov; 121(5):978-89. PMID: 25187999; PMCID: PMC4304638.
  52. Akeju O, Westover MB, Pavone KJ, Sampson AL, Hartnack KE, Brown EN, Purdon PL. Effects of sevoflurane and propofol on frontal electroencephalogram power and coherence. Anesthesiology. 2014 Nov; 121(5):990-8. PMID: 25233374; PMCID: PMC4206606.
  53. Malik WQ, Hochberg LR, Donoghue JP, Brown EN. Modulation depth estimation and variable selection in state-space models for neural interfaces. IEEE Trans Biomed Eng. 2015 Feb; 62(2):570-81. PMID: 25265627; PMCID: PMC4356256.
  54. Halassa MM, Chen Z, Wimmer RD, Brunetti PM, Zhao S, Zikopoulos B, Wang F, Brown EN, Wilson MA. State-dependent architecture of thalamic reticular subnetworks. Cell. 2014 Aug 14; 158(4):808-821. PMID: 25126786; PMCID: PMC4205482.
  55. Solt K, Van Dort CJ, Chemali JJ, Taylor NE, Kenny JD, Brown EN. Electrical stimulation of the ventral tegmental area induces reanimation from general anesthesia. Anesthesiology. 2014 Aug; 121(2):311-9. PMID: 24398816; PMCID: PMC4112744.
  56. Wu W, Chen Z, Gao X, Li Y, Brown EN, Gao S. Probabilistic Common Spatial Patterns for Multichannel EEG Analysis. IEEE Trans Pattern Anal Mach Intell. 2015 Mar; 37(3):639-53. PMID: 26005228; PMCID: PMC4441303.
  57. Babadi B, Brown EN. A review of multitaper spectral analysis. IEEE Trans Biomed Eng. 2014 May; 61(5):1555-64. PMID: 24759284.
    View in: PubMed
  58. Wong KF, Smith AC, Pierce ET, Harrell PG, Walsh JL, Salazar-Gómez AF, Tavares CL, Purdon PL, Brown EN. Statistical modeling of behavioral dynamics during propofol-induced loss of consciousness. J Neurosci Methods. 2014 Apr 30; 227:65-74. PMID: 24530701; PMCID: PMC4304648.
  59. Ba D, Temereanca S, Brown EN. Algorithms for the analysis of ensemble neural spiking activity using simultaneous-event multivariate point-process models. Front Comput Neurosci. 2014; 8:6. PMID: 24575001; PMCID: PMC3918645.
  60. Faghih RT, Dahleh MA, Adler GK, Klerman EB, Brown EN. Deconvolution of serum cortisol levels by using compressed sensing. PLoS One. 2014; 9(1):e85204. PMID: 24489656; PMCID: PMC3904842.
  61. Ching S, Brown EN. Modeling the dynamical effects of anesthesia on brain circuits. Curr Opin Neurobiol. 2014 Apr; 25:116-22. PMID: 24457211; PMCID: PMC4181389.
  62. Mukamel EA, Pirondini E, Babadi B, Wong KF, Pierce ET, Harrell PG, Walsh JL, Salazar-Gomez AF, Cash SS, Eskandar EN, Weiner VS, Brown EN, Purdon PL. A transition in brain state during propofol-induced unconsciousness. J Neurosci. 2014 Jan 15; 34(3):839-45. PMID: 24431442; PMCID: PMC3891963.
  63. Akeju O, Brown EN. Awakened by a sleeping pill. Elife. 2013 Nov 19; 2:e01658. PMID: 24252876; PMCID: PMC3833341.
  64. Liu M, Lewis LD, Shi R, Brown EN, Xu W. Differential requirement for NMDAR activity in SAP97ß-mediated regulation of the number and strength of glutamatergic AMPAR-containing synapses. J Neurophysiol. 2014 Feb; 111(3):648-58. PMID: 24225540; PMCID: PMC3921414.
  65. Citi L, Ba D, Brown EN, Barbieri R. Likelihood methods for point processes with refractoriness. Neural Comput. 2014 Feb; 26(2):237-63. PMID: 24206384.
    View in: PubMed
  66. Shanechi MM, Chemali JJ, Liberman M, Solt K, Brown EN. A brain-machine interface for control of medically-induced coma. PLoS Comput Biol. 2013 Oct; 9(10):e1003284. PMID: 24204231; PMCID: PMC3814408.
  67. Babadi B, Ba D, Purdon PL, Brown EN. Convergence and Stability of a Class of Iteratively Re-weighted Least Squares Algorithms for Sparse Signal Recovery in the Presence of Noise. IEEE Trans Signal Process. 2013 Oct 30; 62(1):183-195. PMID: 26549965.
    View in: PubMed
  68. Ching S, Liberman MY, Chemali JJ, Westover MB, Kenny JD, Solt K, Purdon PL, Brown EN. Real-time closed-loop control in a rodent model of medically induced coma using burst suppression. Anesthesiology. 2013 Oct; 119(4):848-60. PMID: 23770601; PMCID: PMC3857134.
  69. Babadi B, Obregon-Henao G, Lamus C, Hämäläinen MS, Brown EN, Purdon PL. A Subspace Pursuit-based Iterative Greedy Hierarchical solution to the neuromagnetic inverse problem. Neuroimage. 2014 Feb 15; 87:427-43. PMID: 24055554; PMCID: PMC3946905.
  70. Chemali J, Ching S, Purdon PL, Solt K, Brown EN. Burst suppression probability algorithms: state-space methods for tracking EEG burst suppression. J Neural Eng. 2013 Oct; 10(5):056017. PMID: 24018288; PMCID: PMC3793904.
  71. Brown EN, Purdon PL. The aging brain and anesthesia. Curr Opin Anaesthesiol. 2013 Aug; 26(4):414-9. PMID: 23820102.
    View in: PubMed
  72. Lewis LD, Ching S, Weiner VS, Peterfreund RA, Eskandar EN, Cash SS, Brown EN, Purdon PL. Local cortical dynamics of burst suppression in the anaesthetized brain. Brain. 2013 Sep; 136(Pt 9):2727-37. PMID: 23887187; PMCID: PMC3754454.
  73. Brandon Westover M, Shafi MM, Ching S, Chemali JJ, Purdon PL, Cash SS, Brown EN. Real-time segmentation of burst suppression patterns in critical care EEG monitoring. J Neurosci Methods. 2013 Sep 30; 219(1):131-41. PMID: 23891828; PMCID: PMC3939433.
  74. Vijayan S, Ching S, Purdon PL, Brown EN, Kopell NJ. Thalamocortical mechanisms for the anteriorization of a rhythms during propofol-induced unconsciousness. J Neurosci. 2013 Jul 03; 33(27):11070-5. PMID: 23825412; PMCID: PMC3718379.
  75. Liberman MY, Ching S, Chemali J, Brown EN. A closed-loop anesthetic delivery system for real-time control of burst suppression. J Neural Eng. 2013 Aug; 10(4):046004. PMID: 23744607; PMCID: PMC3746775.
  76. Shanechi MM, Williams ZM, Wornell GW, Hu RC, Powers M, Brown EN. A real-time brain-machine interface combining motor target and trajectory intent using an optimal feedback control design. PLoS One. 2013; 8(4):e59049. PMID: 23593130; PMCID: PMC3622681.
  77. Purdon PL, Pierce ET, Mukamel EA, Prerau MJ, Walsh JL, Wong KF, Salazar-Gomez AF, Harrell PG, Sampson AL, Cimenser A, Ching S, Kopell NJ, Tavares-Stoeckel C, Habeeb K, Merhar R, Brown EN. Electroencephalogram signatures of loss and recovery of consciousness from propofol. Proc Natl Acad Sci U S A. 2013 Mar 19; 110(12):E1142-51. PMID: 23487781; PMCID: PMC3607036.
  78. Taylor NE, Chemali JJ, Brown EN, Solt K. Activation of D1 dopamine receptors induces emergence from isoflurane general anesthesia. Anesthesiology. 2013 Jan; 118(1):30-9. PMID: 23221866; PMCID: PMC3527840.
  79. Westover MB, Ching S, Shafi MM, Cash SS, Brown EN. Real-time segmentation and tracking of brain metabolic state in ICU EEG recordings of burst suppression. Conf Proc IEEE Eng Med Biol Soc. 2013; 2013:7108-11. PMID: 24111383; PMCID: PMC3939432.
  80. Krishnaswamy P, Bonmassar G, Purdon PL, Brown EN. Reference-free harmonic regression technique to remove EEG-fMRI ballistocardiogram artifacts. Conf Proc IEEE Eng Med Biol Soc. 2013; 2013:5426-9. PMID: 24110963.
    View in: PubMed
  81. Shanechi MM, Chemali JJ, Liberman M, Solt K, Brown EN. A brain-machine interface for control of burst suppression in medical coma. Conf Proc IEEE Eng Med Biol Soc. 2013; 2013:1575-8. PMID: 24110002.
    View in: PubMed
  82. Vijayan S, Ching S, Purdon PL, Brown EN, Kopell NJ. Biophysical Modeling of Alpha Rhythms During Halothane-Induced Unconsciousness. Int IEEE EMBS Conf Neural Eng. 2013; 1104-1107. PMID: 25284633.
    View in: PubMed
  83. Schwinn DA, Mackensen GB, Brown EN. Understanding the TXA seizure connection. J Clin Invest. 2012 Dec; 122(12):4339-41. PMID: 23187134; PMCID: PMC3533567.
  84. Shanechi MM, Hu RC, Powers M, Wornell GW, Brown EN, Williams ZM. Neural population partitioning and a concurrent brain-machine interface for sequential motor function. Nat Neurosci. 2012 Dec; 15(12):1715-22. PMID: 23143511; PMCID: PMC3509235.
  85. Lewis LD, Weiner VS, Mukamel EA, Donoghue JA, Eskandar EN, Madsen JR, Anderson WS, Hochberg LR, Cash SS, Brown EN, Purdon PL. Rapid fragmentation of neuronal networks at the onset of propofol-induced unconsciousness. Proc Natl Acad Sci U S A. 2012 Dec 04; 109(49):E3377-86. PMID: 23129622; PMCID: PMC3523833.
  86. Wong KF, Gong JJ, Cotten JF, Solt K, Brown EN. Assessing the effects of pharmacological agents on respiratory dynamics using time-series modeling. IEEE Trans Biomed Eng. 2013 Apr; 60(4):1118-25. PMID: 23193230.
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  87. Brown EN, Solt K. Management of opioid analgesic overdose. N Engl J Med. 2012 Oct 04; 367(14):1370-1; author reply 1372-3. PMID: 23034040.
    View in: PubMed
  88. Shanechi MM, Wornell GW, Williams ZM, Brown EN. Feedback-controlled parallel point process filter for estimation of goal-directed movements from neural signals. IEEE Trans Neural Syst Rehabil Eng. 2013 Jan; 21(1):129-40. PMID: 23047892.
    View in: PubMed
  89. Ching S, Brown EN, Kramer MA. Distributed control in a mean-field cortical network model: implications for seizure suppression. Phys Rev E Stat Nonlin Soft Matter Phys. 2012 Aug; 86(2 Pt 1):021920. PMID: 23005798.
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  91. Sarma SV, Cheng ML, Eden U, Williams Z, Brown EN, Eskandar E. The effects of cues on neurons in the basal ganglia in Parkinson's disease. Front Integr Neurosci. 2012; 6:40. PMID: 22855673; PMCID: PMC3405280.
  92. Haslinger R, Pipa G, Lima B, Singer W, Brown EN, Neuenschwander S. Context matters: the illusive simplicity of macaque V1 receptive fields. PLoS One. 2012; 7(7):e39699. PMID: 22802940; PMCID: PMC3389039.
  93. Pipa G, Chen Z, Neuenschwander S, Lima B, Brown EN. Mapping of visual receptive fields by tomographic reconstruction. Neural Comput. 2012 Oct; 24(10):2543-78. PMID: 22734491; PMCID: PMC3972919.
  94. Chemali JJ, Van Dort CJ, Brown EN, Solt K. Active emergence from propofol general anesthesia is induced by methylphenidate. Anesthesiology. 2012 May; 116(5):998-1005. PMID: 22446983; PMCID: PMC3339625.
  95. Temereanca S, Hämäläinen MS, Kuperberg GR, Stufflebeam SM, Halgren E, Brown EN. Eye movements modulate the spatiotemporal dynamics of word processing. J Neurosci. 2012 Mar 28; 32(13):4482-94. PMID: 22457496; PMCID: PMC3499987.
  96. Shimazaki H, Amari S, Brown EN, Grün S. State-space analysis of time-varying higher-order spike correlation for multiple neural spike train data. PLoS Comput Biol. 2012; 8(3):e1002385. PMID: 22412358; PMCID: PMC3297562.
  97. Kodituwakku S, Lazar SW, Indic P, Chen Z, Brown EN, Barbieri R. Point process time-frequency analysis of dynamic respiratory patterns during meditation practice. Med Biol Eng Comput. 2012 Mar; 50(3):261-75. PMID: 22350435; PMCID: PMC3341131.
  98. Ching S, Purdon PL, Vijayan S, Kopell NJ, Brown EN. A neurophysiological-metabolic model for burst suppression. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):3095-100. PMID: 22323592; PMCID: PMC3286963.
  99. Chen Z, Kloosterman F, Brown EN, Wilson MA. Uncovering spatial topology represented by rat hippocampal population neuronal codes. J Comput Neurosci. 2012 Oct; 33(2):227-55. PMID: 22307459; PMCID: PMC3974406.
  100. Jarosiewicz B, Schummers J, Malik WQ, Brown EN, Sur M. Functional biases in visual cortex neurons with identified projections to higher cortical targets. Curr Biol. 2012 Feb 21; 22(4):269-77. PMID: 22305753; PMCID: PMC3288404.
  101. Chen Z, Purdon PL, Brown EN, Barbieri R. A unified point process probabilistic framework to assess heartbeat dynamics and autonomic cardiovascular control. Front Physiol. 2012; 3:4. PMID: 22375120; PMCID: PMC3269663.
  102. Citi L, Valenza G, Purdon PL, Brown EN, Barbieri R. Monitoring heartbeat nonlinear dynamics during general anesthesia by using the instantaneous dominant Lyapunov exponent. Conf Proc IEEE Eng Med Biol Soc. 2012; 2012:3124-7. PMID: 23366587.
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  103. Faghih RT, Savla K, Dahleh MA, Brown EN. Broad range of neural dynamics from a time-varying FitzHugh-Nagumo model and its spiking threshold estimation. IEEE Trans Biomed Eng. 2012 Mar; 59(3):816-23. PMID: 22186931.
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  104. Lamus C, Hämäläinen MS, Temereanca S, Brown EN, Purdon PL. A spatiotemporal dynamic distributed solution to the MEG inverse problem. Neuroimage. 2012 Nov 01; 63(2):894-909. PMID: 22155043; PMCID: PMC3432302.
  105. Putrino DF, Chen Z, Ghosh S, Brown EN. Motor cortical networks for skilled movements have dynamic properties that are related to accurate reaching. Neural Plast. 2011; 2011:413543. PMID: 22007332; PMCID: PMC3191785.
  106. Solt K, Cotten JF, Cimenser A, Wong KF, Chemali JJ, Brown EN. Methylphenidate actively induces emergence from general anesthesia. Anesthesiology. 2011 Oct; 115(4):791-803. PMID: 21934407; PMCID: PMC3178041.
  107. Phillips MA, Colonnese MT, Goldberg J, Lewis LD, Brown EN, Constantine-Paton M. A synaptic strategy for consolidation of convergent visuotopic maps. Neuron. 2011 Aug 25; 71(4):710-24. PMID: 21867886; PMCID: PMC3365514.
  108. Sarma SV, Nguyen DP, Czanner G, Wirth S, Wilson MA, Suzuki W, Brown EN. Computing confidence intervals for point process models. Neural Comput. 2011 Nov; 23(11):2731-45. PMID: 21851280.
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  109. Brooks D, Brown EN, Casler R, Fantini S, Khademhosseini A, Niemi J, Ramachandran R, Rutkove S, Tracey B. Boston research takes center stage. Interview by Pamela Reynolds. IEEE Pulse. 2011 Jul-Aug; 2(4):31-8. PMID: 21791397.
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  110. Malik WQ, Schummers J, Sur M, Brown EN. Denoising two-photon calcium imaging data. PLoS One. 2011; 6(6):e20490. PMID: 21687727; PMCID: PMC3110192.
  111. Long CJ, Purdon PL, Temereanca S, Desai NU, Hämäläinen MS, Brown EN. STATE-SPACE SOLUTIONS TO THE DYNAMIC MAGNETOENCEPHALOGRAPHY INVERSE PROBLEM USING HIGH PERFORMANCE COMPUTING. Ann Appl Stat. 2011 Jun 01; 5(2B):1207-1228. PMID: 22081780.
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  113. Indic P, Bloch-Salisbury E, Bednarek F, Brown EN, Paydarfar D, Barbieri R. Assessment of cardio-respiratory interactions in preterm infants by bivariate autoregressive modeling and surrogate data analysis. Early Hum Dev. 2011 Jul; 87(7):477-87. PMID: 21511413; PMCID: PMC3114161.
  114. LaCount LT, Barbieri R, Park K, Kim J, Brown EN, Kuo B, Napadow V. Static and dynamic autonomic response with increasing nausea perception. Aviat Space Environ Med. 2011 Apr; 82(4):424-33. PMID: 21485400; PMCID: PMC3137518.
  115. Truccolo W, Donoghue JA, Hochberg LR, Eskandar EN, Madsen JR, Anderson WS, Brown EN, Halgren E, Cash SS. Single-neuron dynamics in human focal epilepsy. Nat Neurosci. 2011 May; 14(5):635-41. PMID: 21441925; PMCID: PMC3134302.
  116. Kim S, Putrino D, Ghosh S, Brown EN. A Granger causality measure for point process models of ensemble neural spiking activity. PLoS Comput Biol. 2011 Mar; 7(3):e1001110. PMID: 21455283; PMCID: PMC3063721.
  117. Wu W, Chen Z, Gao S, Brown EN. A hierarchical Bayesian approach for learning sparse spatio-temporal decompositions of multichannel EEG. Neuroimage. 2011 Jun 15; 56(4):1929-45. PMID: 21420499; PMCID: PMC3128889.
  118. Krishnaswamy P, Brown EN, Herr HM. Human leg model predicts ankle muscle-tendon morphology, state, roles and energetics in walking. PLoS Comput Biol. 2011 Mar; 7(3):e1001107. PMID: 21445231; PMCID: PMC3060164.
  119. Plourde E, Delgutte B, Brown EN. A point process model for auditory neurons considering both their intrinsic dynamics and the spectrotemporal properties of an extrinsic signal. IEEE Trans Biomed Eng. 2011 Jun; 58(6):1507-10. PMID: 21317068; PMCID: PMC3118674.
  120. Barnes TD, Mao JB, Hu D, Kubota Y, Dreyer AA, Stamoulis C, Brown EN, Graybiel AM. Advance cueing produces enhanced action-boundary patterns of spike activity in the sensorimotor striatum. J Neurophysiol. 2011 Apr; 105(4):1861-78. PMID: 21307317; PMCID: PMC3075306.
  121. Gong JJ, Wong KF, Cotten JF, Solt K, Brown EN. Correcting for serial dependence in studies of respiratory dynamics. Conf Proc IEEE Eng Med Biol Soc. 2011; 2011:1721-4. PMID: 22254658; PMCID: PMC3767304.
  122. Faghih RT, Savla K, Dahleh MA, Brown EN. A feedback control model for cortisol secretion. Conf Proc IEEE Eng Med Biol Soc. 2011; 2011:716-9. PMID: 22254410.
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  123. Wong KF, Mukamel EA, Salazar AF, Pierce ET, Harrell PG, Walsh JL, Sampson A, Brown EN, Purdon PL. Robust time-varying multivariate coherence estimation: application to electroencephalogram recordings during general anesthesia. Conf Proc IEEE Eng Med Biol Soc. 2011; 2011:4725-8. PMID: 22255393; PMCID: PMC3293406.
  124. Chemali JJ, Wong KF, Solt K, Brown EN. A state-space model of the burst suppression ratio. Conf Proc IEEE Eng Med Biol Soc. 2011; 2011:1431-4. PMID: 22254587; PMCID: PMC3770149.
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  126. Mukamel EA, Wong KF, Prerau MJ, Brown EN, Purdon PL. Phase-based measures of cross-frequency coupling in brain electrical dynamics under general anesthesia. Conf Proc IEEE Eng Med Biol Soc. 2011; 2011:1981-4. PMID: 22254722; PMCID: PMC3282123.
  127. Wong KF, Smith AC, Pierce ET, Harrell PG, Walsh JL, Salazar AF, Tavares CL, Cimenser A, Prerau MJ, Mukamel EA, Sampson A, Purdon PL, Brown EN. Bayesian analysis of trinomial data in behavioral experiments and its application to human studies of general anesthesia. Conf Proc IEEE Eng Med Biol Soc. 2011; 2011:4705-8. PMID: 22255388; PMCID: PMC3282046.
  128. Brown EN, Purdon PL, Van Dort CJ. General anesthesia and altered states of arousal: a systems neuroscience analysis. Annu Rev Neurosci. 2011; 34:601-28. PMID: 21513454; PMCID: PMC3390788.
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  130. Zheng HW, Malik WQ, Runyan CA, Sur M, Brown EN. Modeling two-photon calcium fluorescence of episodic V1 recordings using multifrequency analysis. Conf Proc IEEE Eng Med Biol Soc. 2011; 2011:3016-9. PMID: 22254975; PMCID: PMC4374803.
  131. Citi L, Djilas M, Azevedo-Coste C, Yoshida K, Brown EN, Barbieri R. Point-process analysis of neural spiking activity of muscle spindles recorded from thin-film longitudinal intrafascicular electrodes. Conf Proc IEEE Eng Med Biol Soc. 2011; 2011:2311-4. PMID: 22254803; PMCID: PMC3275426.
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  133. Ching S, Cimenser A, Purdon PL, Brown EN, Kopell NJ. Thalamocortical model for a propofol-induced alpha-rhythm associated with loss of consciousness. Proc Natl Acad Sci U S A. 2010 Dec 28; 107(52):22665-70. PMID: 21149695; PMCID: PMC3012501.
  134. Malik WQ, Truccolo W, Brown EN, Hochberg LR. Efficient decoding with steady-state Kalman filter in neural interface systems. IEEE Trans Neural Syst Rehabil Eng. 2011 Feb; 19(1):25-34. PMID: 21078582; PMCID: PMC3044609.
  135. Chen Z, Purdon PL, Harrell G, Pierce ET, Walsh J, Brown EN, Barbieri R. Dynamic assessment of baroreflex control of heart rate during induction of propofol anesthesia using a point process method. Ann Biomed Eng. 2011 Jan; 39(1):260-76. PMID: 20945159; PMCID: PMC3010293.
  136. Chen Z, Putrino DF, Ghosh S, Barbieri R, Brown EN. Statistical inference for assessing functional connectivity of neuronal ensembles with sparse spiking data. IEEE Trans Neural Syst Rehabil Eng. 2011 Apr; 19(2):121-35. PMID: 20937583; PMCID: PMC3044782.
  137. Putrino D, Brown EN, Mastaglia FL, Ghosh S. Differential involvement of excitatory and inhibitory neurons of cat motor cortex in coincident spike activity related to behavioral context. J Neurosci. 2010 Jun 09; 30(23):8048-56. PMID: 20534853.
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  139. Vijayan S, Hale GJ, Moore CI, Brown EN, Wilson M. Activity in the barrel cortex during active behavior and sleep. J Neurophysiol. 2010 Apr; 103(4):2074-84. PMID: 20164403; PMCID: PMC2853270.
  140. Chen Z, Brown EN, Barbieri R. Characterizing nonlinear heartbeat dynamics within a point process framework. IEEE Trans Biomed Eng. 2010 Jun; 57(6):1335-47. PMID: 20172783; PMCID: PMC2952361.
  141. Sarma SV, Eden UT, Cheng ML, Williams ZM, Hu R, Eskandar E, Brown EN. Using point process models to compare neural spiking activity in the subthalamic nucleus of Parkinson's patients and a healthy primate. IEEE Trans Biomed Eng. 2010 Jun; 57(6):1297-305. PMID: 20172804; PMCID: PMC3822781.
  142. Faghih RT, Savla K, Dahleh MA, Brown EN. The Fitzhugh-Nagumo model: Firing modes with time-varying parameters & parameter estimation. Conf Proc IEEE Eng Med Biol Soc. 2010; 2010:4116-9. PMID: 21096631.
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  143. Kodituwakku S, Lazar SW, Indic P, Brown EN, Barbieri R. Point process time-frequency analysis of respiratory sinus arrhythmia under altered respiration dynamics. Conf Proc IEEE Eng Med Biol Soc. 2010; 2010:1622-5. PMID: 21096135; PMCID: PMC3059743.
  144. Mauri M, Magagnin V, Cipresso P, Mainardi L, Brown EN, Cerutti S, Villamira M, Barbieri R. Psychophysiological signals associated with affective states. Conf Proc IEEE Eng Med Biol Soc. 2010; 2010:3563-6. PMID: 21096828; PMCID: PMC3059749.
  145. Cajigas I, Goldsmith MT, Duschau-Wicke A, Riener R, Smith MA, Brown EN, Bonato P. Assessment of lower extremity motor adaptation via an extension of the force field adaptation paradigm. Conf Proc IEEE Eng Med Biol Soc. 2010; 2010:4522-5. PMID: 21095786; PMCID: PMC3306221.
  146. Chen Z, Purdon PL, Brown EN, Barbieri R. A differential autoregressive modeling approach within a point process framework for non-stationary heartbeat intervals analysis. Conf Proc IEEE Eng Med Biol Soc. 2010; 2010:3567-70. PMID: 21096829; PMCID: PMC3059729.
  147. Smith AC, Scalon JD, Wirth S, Yanike M, Suzuki WA, Brown EN. State-space algorithms for estimating spike rate functions. Comput Intell Neurosci. 2010; 426539. PMID: 19911062; PMCID: PMC2774470.
  148. Nguyen DP, Wilson MA, Brown EN, Barbieri R. Measuring instantaneous frequency of local field potential oscillations using the Kalman smoother. J Neurosci Methods. 2009 Nov 15; 184(2):365-74. PMID: 19699763; PMCID: PMC2767386.
  149. Smith AC, Shah SA, Hudson AE, Purpura KP, Victor JD, Brown EN, Schiff ND. A Bayesian statistical analysis of behavioral facilitation associated with deep brain stimulation. J Neurosci Methods. 2009 Oct 15; 183(2):267-76. PMID: 19576932; PMCID: PMC2743761.
  150. Chen Z, Vijayan S, Barbieri R, Wilson MA, Brown EN. Discrete- and continuous-time probabilistic models and algorithms for inferring neuronal UP and DOWN states. Neural Comput. 2009 Jul; 21(7):1797-862. PMID: 19323637; PMCID: PMC2799196.
  151. Nguyen DP, Kloosterman F, Barbieri R, Brown EN, Wilson MA. Characterizing the dynamic frequency structure of fast oscillations in the rodent hippocampus. Front Integr Neurosci. 2009; 3:11. PMID: 19562084; PMCID: PMC2701674.
  152. Scholz J, Triantafyllou C, Whitfield-Gabrieli S, Brown EN, Saxe R. Distinct regions of right temporo-parietal junction are selective for theory of mind and exogenous attention. PLoS One. 2009; 4(3):e4869. PMID: 19290043; PMCID: PMC2653721.
  153. Chen Z, Brown EN, Barbieri R. Assessment of autonomic control and respiratory sinus arrhythmia using point process models of human heart beat dynamics. IEEE Trans Biomed Eng. 2009 Jul; 56(7):1791-802. PMID: 19272971; PMCID: PMC2804879.
  154. Purdon PL, Pierce ET, Bonmassar G, Walsh J, Harrell PG, Kwo J, Deschler D, Barlow M, Merhar RC, Lamus C, Mullaly CM, Sullivan M, Maginnis S, Skoniecki D, Higgins HA, Brown EN. Simultaneous electroencephalography and functional magnetic resonance imaging of general anesthesia. Ann N Y Acad Sci. 2009 Mar; 1157:61-70. PMID: 19351356; PMCID: PMC2855224.
  155. Chen Z, Putrino DF, Ba DE, Ghosh S, Barbieri R, Brown EN. A regularized point process generalized linear model for assessing the functional connectivity in the cat motor cortex. Conf Proc IEEE Eng Med Biol Soc. 2009; 2009:5006-9. PMID: 19965032; PMCID: PMC2822661.
  156. Chen Z, Purdon PL, Pierce ET, Harrell G, Walsh J, Salazar AF, Tavares CL, Brown EN, Barbieri R. Linear and nonlinear quantification of respiratory sinus arrhythmia during propofol general anesthesia. Conf Proc IEEE Eng Med Biol Soc. 2009; 2009:5336-9. PMID: 19963899; PMCID: PMC2804255.
  157. Malik WQ, Schummers J, Sur M, Brown EN. A statistical model for multiphoton calcium imaging of the brain. Conf Proc IEEE Eng Med Biol Soc. 2009; 2009:7002-5. PMID: 19964727; PMCID: PMC3044606.
  158. Wu W, Chen Z, Gao S, Brown EN. A probabilistic framework for learning robust common spatial patterns. Conf Proc IEEE Eng Med Biol Soc. 2009; 2009:4658-61. PMID: 19963618.
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  160. Temereanca S, Brown EN, Simons DJ. Rapid changes in thalamic firing synchrony during repetitive whisker stimulation. J Neurosci. 2008 Oct 29; 28(44):11153-64. PMID: 18971458; PMCID: PMC2617717.
  161. Yanike M, Wirth S, Smith AC, Brown EN, Suzuki WA. Comparison of associative learning-related signals in the macaque perirhinal cortex and hippocampus. Cereb Cortex. 2009 May; 19(5):1064-78. PMID: 18936274; PMCID: PMC2665157.
  162. Napadow V, Dhond R, Conti G, Makris N, Brown EN, Barbieri R. Brain correlates of autonomic modulation: combining heart rate variability with fMRI. Neuroimage. 2008 Aug 01; 42(1):169-77. PMID: 18524629; PMCID: PMC2603289.
  163. Barbieri R, Brown EN. Application of dynamic point process models to cardiovascular control. Biosystems. 2008 Jul-Aug; 93(1-2):120-5. PMID: 18515000; PMCID: PMC2561955.
  164. Czanner G, Eden UT, Wirth S, Yanike M, Suzuki WA, Brown EN. Analysis of between-trial and within-trial neural spiking dynamics. J Neurophysiol. 2008 May; 99(5):2672-93. PMID: 18216233; PMCID: PMC2430469.
  165. Chen Z, Brown EN, Barbieri R. Characterizing nonlinear heartbeat dynamics within a point process framework. Conf Proc IEEE Eng Med Biol Soc. 2008; 2008:2781-4. PMID: 19163282; PMCID: PMC2644067.
  166. Nguyen DP, Barbieri R, Wilson MA, Brown EN. Instantaneous frequency and amplitude modulation of EEG in the hippocampus reveals state dependent temporal structure. Conf Proc IEEE Eng Med Biol Soc. 2008; 2008:1711-5. PMID: 19163009.
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  167. Barbieri R, Chen Z, Brown EN. Assessment of hippocampal and autonomic neural activity by point process models. Conf Proc IEEE Eng Med Biol Soc. 2008; 2008:3679. PMID: 19163509; PMCID: PMC2652877.
  168. Eden UT, Brown EN. CONTINUOUS-TIME FILTERS FOR STATE ESTIMATION FROM POINT PROCESS MODELS OF NEURAL DATA. Stat Sin. 2008; 18(4):1293-1310. PMID: 22065511.
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  169. Zhang Q, Brown EN, Strangman GE. Adaptive filtering to reduce global interference in evoked brain activity detection: a human subject case study. J Biomed Opt. 2007 Nov-Dec; 12(6):064009. PMID: 18163825.
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  170. Zhang Q, Brown EN, Strangman GE. Adaptive filtering for global interference cancellation and real-time recovery of evoked brain activity: a Monte Carlo simulation study. J Biomed Opt. 2007 Jul-Aug; 12(4):044014. PMID: 17867818.
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  171. Srinivasan L, Eden UT, Mitter SK, Brown EN. General-purpose filter design for neural prosthetic devices. J Neurophysiol. 2007 Oct; 98(4):2456-75. PMID: 17522167.
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  172. Behn CG, Brown EN, Scammell TE, Kopell NJ. Mathematical model of network dynamics governing mouse sleep-wake behavior. J Neurophysiol. 2007 Jun; 97(6):3828-40. PMID: 17409167; PMCID: PMC2259448.
  173. Ergün A, Barbieri R, Eden UT, Wilson MA, Brown EN. Construction of point process adaptive filter algorithms for neural systems using sequential Monte Carlo methods. IEEE Trans Biomed Eng. 2007 Mar; 54(3):419-28. PMID: 17355053.
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  174. Srinivasan L, Brown EN. A state-space framework for movement control to dynamic goals through brain-driven interfaces. IEEE Trans Biomed Eng. 2007 Mar; 54(3):526-35. PMID: 17355066.
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  175. Smith AC, Wirth S, Suzuki WA, Brown EN. Bayesian analysis of interleaved learning and response bias in behavioral experiments. J Neurophysiol. 2007 Mar; 97(3):2516-24. PMID: 17182907.
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  176. Srinivasan L, Eden UT, Willsky AS, Brown EN. A state-space analysis for reconstruction of goal-directed movements using neural signals. Neural Comput. 2006 Oct; 18(10):2465-94. PMID: 16907633.
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  177. Karameh FN, Dahleh MA, Brown EN, Massaquoi SG. Modeling the contribution of lamina 5 neuronal and network dynamics to low frequency EEG phenomena. Biol Cybern. 2006 Oct; 95(4):289-310. PMID: 16897093.
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  178. Barbieri R, Brown EN. Correction of erroneous and ectopic beats using a point process adaptive algorithm. Conf Proc IEEE Eng Med Biol Soc. 2006; 1:3373-6. PMID: 17945770.
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  179. Scotti S, Mauri M, Barbieri R, Jawad B, Cerutti S, Mainardi L, Brown EN, Villamira MA. Automatic quantitative evaluation of emotions in E-learning applications. Conf Proc IEEE Eng Med Biol Soc. 2006; 1:1359-62. PMID: 17946457.
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  180. Frank LM, Brown EN, Stanley GB. Hippocampal and cortical place cell plasticity: implications for episodic memory. Hippocampus. 2006; 16(9):775-84. PMID: 16921502.
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  181. Barbieri R, Brown EN. Analysis of heartbeat dynamics by point process adaptive filtering. IEEE Trans Biomed Eng. 2006 Jan; 53(1):4-12. PMID: 16402597.
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  182. Lee WC, Huang H, Feng G, Sanes JR, Brown EN, So PT, Nedivi E. Dynamic remodeling of dendritic arbors in GABAergic interneurons of adult visual cortex. PLoS Biol. 2006 Feb; 4(2):e29. PMID: 16366735; PMCID: PMC1318477.
  183. Indic P, Brown EN. Characterizing the amplitude dynamics of the human core-temperature circadian rhythm using a stochastic-dynamic model. J Theor Biol. 2006 Apr 21; 239(4):499-506. PMID: 16223510.
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  184. Okatan M, Wilson MA, Brown EN. Analyzing functional connectivity using a network likelihood model of ensemble neural spiking activity. Neural Comput. 2005 Sep; 17(9):1927-61. PMID: 15992486.
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  185. Kass RE, Ventura V, Brown EN. Statistical issues in the analysis of neuronal data. J Neurophysiol. 2005 Jul; 94(1):8-25. PMID: 15985692.
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  186. Law JR, Flanery MA, Wirth S, Yanike M, Smith AC, Frank LM, Suzuki WA, Brown EN, Stark CE. Functional magnetic resonance imaging activity during the gradual acquisition and expression of paired-associate memory. J Neurosci. 2005 Jun 15; 25(24):5720-9. PMID: 15958738.
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  187. Barbieri R, Wilson MA, Frank LM, Brown EN. An analysis of hippocampal spatio-temporal representations using a Bayesian algorithm for neural spike train decoding. IEEE Trans Neural Syst Rehabil Eng. 2005 Jun; 13(2):131-6. PMID: 16003890.
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  188. Suzuki WA, Brown EN. Behavioral and neurophysiological analyses of dynamic learning processes. Behav Cogn Neurosci Rev. 2005 Jun; 4(2):67-95. PMID: 16251726.
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  189. Indic P, Forger DB, St Hilaire MA, Dean DA, Brown EN, Kronauer RE, Klerman EB, Jewett ME. Comparison of amplitude recovery dynamics of two limit cycle oscillator models of the human circadian pacemaker. Chronobiol Int. 2005; 22(4):613-29. PMID: 16147894; PMCID: PMC3797655.
  190. Long C, Brown EN, Manoach D, Solo V. Spatiotemporal wavelet analysis for functional MRI. Neuroimage. 2004 Oct; 23(2):500-16. PMID: 15488399.
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  191. Smith AC, Stefani MR, Moghaddam B, Brown EN. Analysis and design of behavioral experiments to characterize population learning. J Neurophysiol. 2005 Mar; 93(3):1776-92. PMID: 15456798.
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  192. Barbieri R, Matten EC, Alabi AA, Brown EN. A point-process model of human heartbeat intervals: new definitions of heart rate and heart rate variability. Am J Physiol Heart Circ Physiol. 2005 Jan; 288(1):H424-35. PMID: 15374824.
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  193. Truccolo W, Eden UT, Fellows MR, Donoghue JP, Brown EN. A point process framework for relating neural spiking activity to spiking history, neural ensemble, and extrinsic covariate effects. J Neurophysiol. 2005 Feb; 93(2):1074-89. PMID: 15356183.
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  194. Frank LM, Stanley GB, Brown EN. Hippocampal plasticity across multiple days of exposure to novel environments. J Neurosci. 2004 Sep 01; 24(35):7681-9. PMID: 15342735.
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  195. Brown EN, Kass RE, Mitra PP. Multiple neural spike train data analysis: state-of-the-art and future challenges. Nat Neurosci. 2004 May; 7(5):456-61. PMID: 15114358.
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  196. Eden UT, Frank LM, Barbieri R, Solo V, Brown EN. Dynamic analysis of neural encoding by point process adaptive filtering. Neural Comput. 2004 May; 16(5):971-98. PMID: 15070506.
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  197. Barbieri R, Frank LM, Nguyen DP, Quirk MC, Solo V, Wilson MA, Brown EN. Dynamic analyses of information encoding in neural ensembles. Neural Comput. 2004 Feb; 16(2):277-307. PMID: 15006097.
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  198. Smith AC, Frank LM, Wirth S, Yanike M, Hu D, Kubota Y, Graybiel AM, Suzuki WA, Brown EN. Dynamic analysis of learning in behavioral experiments. J Neurosci. 2004 Jan 14; 24(2):447-61. PMID: 14724243.
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  199. Brown EN, Solo V, Choe Y, Zhang Z. Measuring period of human biological clock: infill asymptotic analysis of harmonic regression parameter estimates. Methods Enzymol. 2004; 383:382-405. PMID: 15063659.
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  200. Frank LM, Brown EN. Persistent activity and memory in the entorhinal cortex. Trends Neurosci. 2003 Aug; 26(8):400-1. PMID: 12900167.
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  201. Klerman EB, Adler GK, Jin M, Maliszewski AM, Brown EN. A statistical model of diurnal variation in human growth hormone. Am J Physiol Endocrinol Metab. 2003 Nov; 285(5):E1118-26. PMID: 12888486.
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  202. Wirth S, Yanike M, Frank LM, Smith AC, Brown EN, Suzuki WA. Single neurons in the monkey hippocampus and learning of new associations. Science. 2003 Jun 06; 300(5625):1578-81. PMID: 12791995.
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  203. Smith AC, Brown EN. Estimating a state-space model from point process observations. Neural Comput. 2003 May; 15(5):965-91. PMID: 12803953.
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  204. Nguyen DP, Frank LM, Brown EN. An application of reversible-jump Markov chain Monte Carlo to spike classification of multi-unit extracellular recordings. Network. 2003 Feb; 14(1):61-82. PMID: 12617059.
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  205. Bonmassar G, Purdon PL, Jääskeläinen IP, Chiappa K, Solo V, Brown EN, Belliveau JW. Motion and ballistocardiogram artifact removal for interleaved recording of EEG and EPs during MRI. Neuroimage. 2002 Aug; 16(4):1127-41. PMID: 12202099.
    View in: PubMed
  206. Frank LM, Eden UT, Solo V, Wilson MA, Brown EN. Contrasting patterns of receptive field plasticity in the hippocampus and the entorhinal cortex: an adaptive filtering approach. J Neurosci. 2002 May 01; 22(9):3817-30. PMID: 11978857.
    View in: PubMed
  207. Brown EN, Barbieri R, Ventura V, Kass RE, Frank LM. The time-rescaling theorem and its application to neural spike train data analysis. Neural Comput. 2002 Feb; 14(2):325-46. PMID: 11802915.
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  208. Brown EN, Nguyen DP, Frank LM, Wilson MA, Solo V. An analysis of neural receptive field plasticity by point process adaptive filtering. Proc Natl Acad Sci U S A. 2001 Oct 09; 98(21):12261-6. PMID: 11593043; PMCID: PMC59830.
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