Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Zhongcong Xie, Ph.D., M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AG070257 (CHENG, LEO L) Feb 15, 2021 - Jan 31, 2026
    Metabolomic characterization of normal aging and Alzheimer's disease under anesthesia- surgery stimuli
    Role: Co-Principal Investigator
  2. RF1AG070761 (XIE, ZHONGCONG) Sep 15, 2020 - Aug 31, 2024
    General Anesthesia and Alzheimer's Disease Neuropathogenesis
    Role: Principal Investigator
  3. R21HD098754 (XIE, ZHONGCONG) May 1, 2019 - Apr 30, 2021
    Tau/pTau as Biomarkers of Anesthesia/Surgery-Associated Neurocognitive Outcomes in Children
    Role: Principal Investigator
  4. R01AG062509 (XIE, ZHONGCONG) Apr 15, 2019 - Feb 29, 2024
    Postoperative Delirium and Alzheimer's Disease Related Dementias
    Role: Principal Investigator
  5. R01HD086977 (XIE, ZHONGCONG) Apr 22, 2016 - Jan 31, 2021
    Tau/P-Tau as Biomarkers of Anesthesia- and Surgery-Induced Cognitive Impairment in a Murine Model
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Yang Y, Liang F, Gao J, Dong Y, Zhang Y, Yang G, Soriano SG, Feng HJ, Xie Z. Testosterone attenuates sevoflurane-induced tau phosphorylation and cognitive impairment in neonatal male mice. Br J Anaesth. 2021 Oct 19. PMID: 34686310.
    Citations:    Fields:    
  2. Dong Y, Liang F, Huang L, Fang F, Yang G, Tanzi RE, Zhang Y, Quan Q, Xie Z. The anesthetic sevoflurane induces tau trafficking from neurons to microglia. Commun Biol. 2021 05 12; 4(1):560. PMID: 33980987.
    Citations: 2     Translation:AnimalsCells
  3. Vasunilashorn SM, Ngo LH, Dillon ST, Fong TG, Carlyle BC, Kivisäkk P, Trombetta BA, Vlassakov KV, Kunze LJ, Arnold SE, Xie Z, Inouye SK, Libermann TA, Marcantonio ER. Plasma and cerebrospinal fluid inflammation and the blood-brain barrier in older surgical patients: the Role of Inflammation after Surgery for Elders (RISE) study. J Neuroinflammation. 2021 Apr 30; 18(1):103. PMID: 33931093.
    Citations:    Fields:    
  4. Fong TG, Chan NY, Dillon ST, Zhou W, Tripp B, Ngo LH, Otu HH, Inouye SK, Vasunilashorn SM, Cooper Z, Xie Z, Marcantonio ER, Libermann TA. Identification of Plasma Proteome Signatures Associated With Surgery Using SOMAscan. Ann Surg. 2021 04 01; 273(4):732-742. PMID: 30946084.
    Citations: 8     Fields:    Translation:Humans
  5. Hanidziar D, Baldyga K, Ji CS, Lu J, Zheng H, Wiener-Kronish J, Xie Z. Standard Sedation and Sedation With Isoflurane in Mechanically Ventilated Patients With Coronavirus Disease 2019. Crit Care Explor. 2021 Mar; 3(3):e0370. PMID: 33786446.
  6. Vasunilashorn SM, Dillon ST, Chan NY, Fong TG, Joseph M, Tripp B, Xie Z, Ngo LH, Lee CG, Elias JA, Otu HH, Inouye S, Marcantonio ER, Libermann TA. Proteome-Wide Analysis using SOMAscan Identifies and Validates Chitinase-3-Like Protein 1 as a Risk and Disease Marker of Delirium Among Older Adults Undergoing Major Elective Surgery. J Gerontol A Biol Sci Med Sci. 2021 Feb 04. PMID: 33539520.
    Citations:    Fields:    
  7. Yu Y, Yang Y, Tan H, Boukhali M, Khatri A, Yu Y, Hua F, Liu L, Li M, Yang G, Dong Y, Zhang Y, Haas W, Xie Z. Tau Contributes to Sevoflurane-induced Neurocognitive Impairment in Neonatal Mice. Anesthesiology. 2020 09; 133(3):595-610. PMID: 32701572.
    Citations: 4     Fields:    Translation:Animals
  8. Vasunilashorn SM, Ngo LH, Inouye SK, Fong TG, Jones RN, Dillon ST, Libermann TA, O'Connor M, Arnold SE, Xie Z, Marcantonio ER. Apolipoprotein E genotype and the association between C-reactive protein and postoperative delirium: Importance of gene-protein interactions. Alzheimers Dement. 2020 03; 16(3):572-580. PMID: 31761478.
    Citations: 3     Fields:    Translation:Humans
  9. Eckenhoff RG, Maze M, Xie Z, Culley DJ, Goodlin SJ, Zuo Z, Wei H, Whittington RA, Terrando N, Orser BA, Eckenhoff MF. Perioperative Neurocognitive Disorder: State of the Preclinical Science. Anesthesiology. 2020 01; 132(1):55-68. PMID: 31834869.
    Citations: 14     Fields:    Translation:Animals
  10. Daiello LA, Racine AM, Yun Gou R, Marcantonio ER, Xie Z, Kunze LJ, Vlassakov KV, Inouye SK, Jones RN, Alsop D, Travison T, Arnold S, Cooper Z, Dickerson B, Fong T, Metzger E, Pascual-Leone A, Schmitt EM, Shafi M, Cavallari M, Dai W, Dillon ST, McElhaney J, Guttmann C, Hshieh T, Kuchel G, Libermann T, Ngo L, Press D, Saczynski J, Vasunilashorn S, O'Connor M, Kimchi E, Strauss J, Wong B, Belkin M, Ayres D, Callery M, Pomposelli F, Wright J, Schermerhorn M, Abrantes T, Albuquerque A, Bertrand S, Brown A, Callahan A, D'Aquila M, Dowal S, Fox M, Gallagher J, Anna Gersten R, Hodara A, Helfand B, Inloes J, Kettell J, Kuczmarska A, Nee J, Nemeth E, Ochsner L, Palihnich K, Parisi K, Puelle M, Rastegar S, Vella M, Xu G, Bryan M, Guess J, Enghorn D, Gross A, Gou Y, Habtemariam D, Isaza I, Kosar C, Rockett C, Tommet D, Gruen T, Ross M, Tasker K, Gee J, Kolanowski A, Pisani M, de Rooij S, Rogers S, Studenski S, Stern Y, Whittemore A, Gottlieb G, Orav J, Sperling R. Postoperative Delirium and Postoperative Cognitive Dysfunction: Overlap and Divergence. Anesthesiology. 2019 09; 131(3):477-491. PMID: 31166241.
    Citations: 27     Fields:    Translation:Humans
  11. Shi Z, Mei X, Li C, Chen Y, Zheng H, Wu Y, Zheng H, Liu L, Marcantonio ER, Xie Z, Shen Y. Postoperative Delirium Is Associated with Long-term Decline in Activities of Daily Living. Anesthesiology. 2019 09; 131(3):492-500. PMID: 31335550.
    Citations: 15     Fields:    Translation:Humans
  12. Ton HT, Yang L, Xie Z. Sevoflurane increases locomotion activity in mice. PLoS One. 2019; 14(5):e0206649. PMID: 31112538.
    Citations: 1     Fields:    Translation:Animals
  13. Vasunilashorn SM, Ngo LH, Chan NY, Zhou W, Dillon ST, Otu HH, Inouye SK, Wyrobnik I, Kuchel GA, McElhaney JE, Xie Z, Alsop DC, Jones RN, Libermann TA, Marcantonio ER. Development of a Dynamic Multi-Protein Signature of Postoperative Delirium. J Gerontol A Biol Sci Med Sci. 2019 01 16; 74(2):261-268. PMID: 29529166.
    Citations: 10     Fields:    Translation:Humans
  14. Vasunilashorn SM, Ngo LH, Jones RN, Inouye SK, Hall KT, Gallagher J, Dillon ST, Xie Z, Libermann TA, Marcantonio ER. The Association Between C-Reactive Protein and Postoperative Delirium Differs by Catechol-O-Methyltransferase Genotype. Am J Geriatr Psychiatry. 2019 01; 27(1):1-8. PMID: 30424994.
    Citations: 4     Fields:    Translation:Humans
  15. Xie Z, Shen Y. New biomarkers of postoperative neurocognitive disorders. Nat Rev Neurol. 2018 Jun; 14(6):320-321. PMID: 29622780.
    Citations:    Fields:    Translation:Humans
  16. Lu H, Liufu N, Dong Y, Xu G, Zhang Y, Shu L, Soriano SG, Zheng H, Yu B, Xie Z. Sevoflurane Acts on Ubiquitination-Proteasome Pathway to Reduce Postsynaptic Density 95 Protein Levels in Young Mice. Anesthesiology. 2017 12; 127(6):961-975. PMID: 28968276.
    Citations: 22     Fields:    Translation:AnimalsCells
  17. Shen S, Lim G, You Z, Ding W, Huang P, Ran C, Doheny J, Caravan P, Tate S, Hu K, Kim H, McCabe M, Huang B, Xie Z, Kwon D, Chen L, Mao J. Gut microbiota is critical for the induction of chemotherapy-induced pain. Nat Neurosci. 2017 Sep; 20(9):1213-1216. PMID: 28714953.
    Citations: 48     Fields:    Translation:AnimalsCells
  18. Li C, Dong Y, Chen D, Xie Z, Zhang Y. Mild Hypothermia Attenuates the Anesthetic Isoflurane-Induced Cytotoxicity. Front Cell Neurosci. 2017; 11:15. PMID: 28228717.
    Citations: 1     
  19. Dong Y, Xu Z, Huang L, Zhang Y, Xie Z. Peripheral surgical wounding may induce cognitive impairment through interlukin-6-dependent mechanisms in aged mice. Med Gas Res. 2016 Oct-Dec; 6(4):180-186. PMID: 28217289.
    Citations: 7     Fields:    
  20. Culley DJ, Flaherty D, Reddy S, Fahey MC, Rudolph J, Huang CC, Liu X, Xie Z, Bader AM, Hyman BT, Blacker D, Crosby G. Preoperative Cognitive Stratification of Older Elective Surgical Patients: A Cross-Sectional Study. Anesth Analg. 2016 07; 123(1):186-92. PMID: 27028776.
    Citations: 22     Fields:    Translation:Humans
  21. Liang F, Zhang Y, Hong W, Dong Y, Xie Z, Quan Q. Direct Tracking of Amyloid and Tu Dynamics in Neuroblastoma Cells Using Nanoplasmonic Fiber Tip Probes. . 2016 07 13; 16(7):3989-94. PMID: 27266855.
    Citations: 4     Translation:HumansCells
  22. Xie Z, Wang H. In Response. Anesth Analg. 2016 Apr; 122(4):1225. PMID: 26991630.
    Citations:    Fields:    Translation:HumansAnimals
  23. Yuan J, Cui G, Li W, Zhang X, Wang X, Zheng H, Zhang J, Xiang S, Xie Z. Propofol Enhances Hemoglobin-Induced Cytotoxicity in Neurons. Anesth Analg. 2016 Apr; 122(4):1024-30. PMID: 26771264.
    Citations: 2     Fields:    Translation:AnimalsCells
  24. Ren Q, Peng M, Dong Y, Zhang Y, Chen M, Yin N, Marcantonio ER, Xie Z. Surgery plus anesthesia induces loss of attention in mice. Front Cell Neurosci. 2015; 9:346. PMID: 26441522.
    Citations: 19     
  25. Wang H, Xu Z, Wu A, Dong Y, Zhang Y, Yue Y, Xie Z. 2-deoxy-D-glucose enhances anesthetic effects in mice. Anesth Analg. 2015 Feb; 120(2):312-9. PMID: 25390277.
    Citations: 4     Fields:    Translation:HumansAnimals
  26. Sun Y, Zhang Y, Cheng B, Dong Y, Pan C, Li T, Xie Z. Glucose may attenuate isoflurane-induced caspase-3 activation in H4 human neuroglioma cells. Anesth Analg. 2014 Dec; 119(6):1373-80. PMID: 25068691.
    Citations: 7     Fields:    Translation:HumansCells
  27. Cheng B, Zhang Y, Wang A, Dong Y, Xie Z. Vitamin C Attenuates Isoflurane-Induced Caspase-3 Activation and Cognitive Impairment. Mol Neurobiol. 2015 Dec; 52(3):1580-1589. PMID: 25367886.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  28. Tao G, Zhang J, Zhang L, Dong Y, Yu B, Crosby G, Culley DJ, Zhang Y, Xie Z. Sevoflurane induces tau phosphorylation and glycogen synthase kinase 3ß activation in young mice. Anesthesiology. 2014 Sep; 121(3):510-27. PMID: 24787352.
    Citations: 34     Fields:    Translation:AnimalsCells
  29. Yang L, Xin X, Zhang J, Zhang L, Dong Y, Zhang Y, Mao J, Xie Z. Inflammatory pain may induce cognitive impairment through an interlukin-6-dependent and postsynaptic density-95-associated mechanism. Anesth Analg. 2014 Aug; 119(2):471-480. PMID: 24878682.
    Citations: 8     Fields:    Translation:AnimalsCells
  30. Li XM, Su F, Ji MH, Zhang GF, Qiu LL, Jia M, Gao J, Xie Z, Yang JJ. Disruption of hippocampal neuregulin 1-ErbB4 signaling contributes to the hippocampus-dependent cognitive impairment induced by isoflurane in aged mice. Anesthesiology. 2014 Jul; 121(1):79-88. PMID: 24589481.
    Citations: 25     Fields:    Translation:AnimalsCells
  31. Culley DJ, Snayd M, Baxter MG, Xie Z, Lee IH, Rudolph J, Inouye SK, Marcantonio ER, Crosby G. Systemic inflammation impairs attention and cognitive flexibility but not associative learning in aged rats: possible implications for delirium. Front Aging Neurosci. 2014; 6:107. PMID: 24959140.
    Citations: 25     
  32. Zhang J, Dong Y, Zhou C, Zhang Y, Xie Z. Anesthetic sevoflurane reduces levels of hippocalcin and postsynaptic density protein 95. Mol Neurobiol. 2015; 51(3):853-63. PMID: 24870966.
    Citations: 16     Fields:    Translation:AnimalsCells
  33. Xu Z, Dong Y, Wang H, Culley DJ, Marcantonio ER, Crosby G, Tanzi RE, Zhang Y, Xie Z. Peripheral surgical wounding and age-dependent neuroinflammation in mice. PLoS One. 2014; 9(5):e96752. PMID: 24796537.
    Citations: 28     Fields:    Translation:Animals
  34. Xie Z, Swain CA, Ward SA, Zheng H, Dong Y, Sunder N, Burke DW, Escobar D, Zhang Y, Marcantonio ER. Preoperative cerebrospinal fluid ß-Amyloid/Tau ratio and postoperative delirium. Ann Clin Transl Neurol. 2014 May 01; 1(5):319-328. PMID: 24860840.
    Citations: 16     Fields:    
  35. Sun Y, Cheng B, Dong Y, Li T, Xie Z, Zhang Y. Time-Dependent Effects of Anesthetic Isoflurane on Reactive Oxygen Species Levels in HEK-293 Cells. Brain Sci. 2014 Apr 22; 4(2):311-20. PMID: 24961763.
    Citations: 5     
  36. Zhang Y, Shao H, Dong Y, Swain CA, Yu B, Xia W, Xie Z. Chronic treatment with anesthetic propofol attenuates ß-amyloid protein levels in brain tissues of aged mice. Transl Neurodegener. 2014 Apr 11; 3(1):8. PMID: 24725331.
    Citations: 9     
  37. Zhang Y, Pan C, Wu X, Dong Y, Culley DJ, Crosby G, Li T, Xie Z. Different effects of anesthetic isoflurane on caspase-3 activation and cytosol cytochrome c levels between mice neural progenitor cells and neurons. Front Cell Neurosci. 2014; 8:14. PMID: 24523673.
    Citations: 5     
  38. Xu Z, Dong Y, Wang H, Culley DJ, Marcantonio ER, Crosby G, Tanzi RE, Zhang Y, Xie Z. Age-dependent postoperative cognitive impairment and Alzheimer-related neuropathology in mice. Sci Rep. 2014 Jan 20; 4:3766. PMID: 24441878.
    Citations: 42     Fields:    Translation:HumansAnimals
  39. Shao H, Zhang Y, Dong Y, Yu B, Xia W, Xie Z. Chronic treatment with anesthetic propofol improves cognitive function and attenuates caspase activation in both aged and Alzheimer's disease transgenic mice. J Alzheimers Dis. 2014; 41(2):499-513. PMID: 24643139.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  40. Culley DJ, Fahy BG, Xie Z, Lekowski R, Buetler S, Liu X, Cohen NH, Crosby G. Academic productivity of directors of ACGME-accredited residency programs in surgery and anesthesiology. Anesth Analg. 2014 Jan; 118(1):200-5. PMID: 24247229.
    Citations: 4     Fields:    Translation:Humans
  41. Zhang X, Xin X, Dong Y, Zhang Y, Yu B, Mao J, Xie Z. Surgical incision-induced nociception causes cognitive impairment and reduction in synaptic NMDA receptor 2B in mice. J Neurosci. 2013 Nov 06; 33(45):17737-48. PMID: 24198365.
    Citations: 28     Fields:    Translation:AnimalsCells
  42. Zhang Y, Dong Y, Zheng H, Shie V, Wang H, Busscher JJ, Yue Y, Xu Z, Xie Z. Sevoflurane inhibits neurogenesis and the Wnt-catenin signaling pathway in mouse neural progenitor cells. Curr Mol Med. 2013 Nov; 13(9):1446-54. PMID: 23971735.
    Citations: 20     Fields:    Translation:AnimalsCells
  43. Xie Z. Cancer prognosis: can anesthesia play a role? Anesthesiology. 2013 Sep; 119(3):501-3. PMID: 23756456.
    Citations: 7     Fields:    Translation:HumansCells
  44. Xie Z, McAuliffe S, Swain CA, Ward SA, Crosby CA, Zheng H, Sherman J, Dong Y, Zhang Y, Sunder N, Burke D, Washicosky KJ, Tanzi RE, Marcantonio ER. Cerebrospinal fluid aß to tau ratio and postoperative cognitive change. Ann Surg. 2013 Aug; 258(2):364-9. PMID: 23732272.
    Citations: 28     Fields:    Translation:HumansCTClinical Trials
  45. Xie Z. Neuronal vulnerability to anesthesia neurotoxicity depends on age of neurons. Ann Neurol. 2013 Jun; 73(6):686-7. PMID: 23595639.
    Citations: 1     Fields:    Translation:HumansCells
  46. Dong Y, Wu X, Zhang G, Xu Z, Zhang Y, Gautam V, Kovacs DM, Wu A, Yue Y, Xie Z. Isoflurane facilitates synaptic NMDA receptor endocytosis in mice primary neurons. Curr Mol Med. 2013 May; 13(4):488-98. PMID: 22950384.
    Citations: 8     Fields:    Translation:AnimalsCells
  47. Zheng H, Dong Y, Xu Z, Crosby G, Culley DJ, Zhang Y, Xie Z. Sevoflurane anesthesia in pregnant mice induces neurotoxicity in fetal and offspring mice. Anesthesiology. 2013 Mar; 118(3):516-26. PMID: 23314109.
    Citations: 61     Fields:    Translation:Animals
  48. Shen X, Dong Y, Xu Z, Wang H, Miao C, Soriano SG, Sun D, Baxter MG, Zhang Y, Xie Z. Selective anesthesia-induced neuroinflammation in developing mouse brain and cognitive impairment. Anesthesiology. 2013 Mar; 118(3):502-15. PMID: 23314110.
    Citations: 127     Fields:    Translation:Animals
  49. Zhang Y, Xie Z. Anesthetics isoflurane and desflurane differently affect mitochondrial function, learning, and memory. Ann Neurol. 2012 Oct; 72(4):630. PMID: 23109162.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  50. Zhang Y, Dong Y, Xu Z, Xie Z. Propofol and magnesium attenuate isoflurane-induced caspase-3 activation via inhibiting mitochondrial permeability transition pore. Med Gas Res. 2012 Aug 17; 2(1):20. PMID: 22901676.
    Citations: 13     Fields:    
  51. Xie Z, Xu Z. General anesthetics and ß-amyloid protein. Prog Neuropsychopharmacol Biol Psychiatry. 2013 Dec 02; 47:140-6. PMID: 22918033.
    Citations: 17     Fields:    Translation:Humans
  52. Zhu B, Dong Y, Xu Z, Gompf HS, Ward SA, Xue Z, Miao C, Zhang Y, Chamberlin NL, Xie Z. Sleep disturbance induces neuroinflammation and impairment of learning and memory. Neurobiol Dis. 2012 Dec; 48(3):348-55. PMID: 22776332.
    Citations: 45     Fields:    Translation:Animals
  53. Cooper O, Seo H, Andrabi S, Guardia-Laguarta C, Graziotto J, Sundberg M, McLean JR, Carrillo-Reid L, Xie Z, Osborn T, Hargus G, Deleidi M, Lawson T, Bogetofte H, Perez-Torres E, Clark L, Moskowitz C, Mazzulli J, Chen L, Volpicelli-Daley L, Romero N, Jiang H, Uitti RJ, Huang Z, Opala G, Scarffe LA, Dawson VL, Klein C, Feng J, Ross OA, Trojanowski JQ, Lee VM, Marder K, Surmeier DJ, Wszolek ZK, Przedborski S, Krainc D, Dawson TM, Isacson O. Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease. Sci Transl Med. 2012 Jul 04; 4(141):141ra90. PMID: 22764206.
    Citations: 204     Fields:    Translation:HumansCells
  54. Dong Y, Wu X, Xu Z, Zhang Y, Xie Z. Anesthetic isoflurane increases phosphorylated tau levels mediated by caspase activation and Aß generation. PLoS One. 2012; 7(6):e39386. PMID: 22745746.
    Citations: 36     Fields:    Translation:AnimalsCells
  55. Xie Z, Dong Y, Maeda U, Xia W, Tanzi RE. RNAi-mediated knock-down of Dab and Numb attenuate Aß levels via ?-secretase mediated APP processing. Transl Neurodegener. 2012 Mar 22; 1(1):8. PMID: 23211096.
    Citations: 3     
  56. Zhang Y, Xu Z, Wang H, Dong Y, Shi HN, Culley DJ, Crosby G, Marcantonio ER, Tanzi RE, Xie Z. Anesthetics isoflurane and desflurane differently affect mitochondrial function, learning, and memory. Ann Neurol. 2012 May; 71(5):687-98. PMID: 22368036.
    Citations: 112     Fields:    Translation:HumansAnimalsCells
  57. Vlisides P, Xie Z. Neurotoxicity of general anesthetics: an update. Curr Pharm Des. 2012; 18(38):6232-40. PMID: 22762477.
    Citations: 17     Fields:    Translation:HumansAnimals
  58. Zhang B, Tian M, Zhen Y, Yue Y, Sherman J, Zheng H, Li S, Tanzi RE, Marcantonio ER, Xie Z. The effects of isoflurane and desflurane on cognitive function in humans. Anesth Analg. 2012 Feb; 114(2):410-5. PMID: 22075020.
    Citations: 40     Fields:    Translation:Humans
  59. Xu Z, Dong Y, Wu X, Zhang J, McAuliffe S, Pan C, Zhang Y, Ichinose F, Yue Y, Xie Z. The potential dual effects of anesthetic isoflurane on Aß-induced apoptosis. Curr Alzheimer Res. 2011 Nov; 8(7):741-52. PMID: 21244349.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  60. Zhang Y, Zhen Y, Dong Y, Xu Z, Yue Y, Golde TE, Tanzi RE, Moir RD, Xie Z. Anesthetic propofol attenuates the isoflurane-induced caspase-3 activation and Aß oligomerization. PLoS One. 2011; 6(11):e27019. PMID: 22069482.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  61. Culley DJ, Boyd JD, Palanisamy A, Xie Z, Kojima K, Vacanti CA, Tanzi RE, Crosby G. Isoflurane decreases self-renewal capacity of rat cultured neural stem cells. Anesthesiology. 2011 Oct; 115(4):754-63. PMID: 21666433.
    Citations: 25     Fields:    Translation:AnimalsCells
  62. Zhang J, Dong Y, Xu Z, Zhang Y, Pan C, McAuliffe S, Ichinose F, Yue Y, Liang W, Xie Z. 2-Deoxy-D-glucose attenuates isoflurane-induced cytotoxicity in an in vitro cell culture model of H4 human neuroglioma cells. Anesth Analg. 2011 Dec; 113(6):1468-75. PMID: 21965367.
    Citations: 11     Fields:    Translation:HumansCells
  63. Dong Y, Xu Z, Zhang Y, McAuliffe S, Wang H, Shen X, Yue Y, Xie Z. RNA interference-mediated silencing of BACE and APP attenuates the isoflurane-induced caspase activation. Med Gas Res. 2011 Apr 28; 1(1):5. PMID: 22146340.
    Citations: 8     Fields:    
  64. Pan C, Xu Z, Dong Y, Zhang Y, Zhang J, McAuliffe S, Yue Y, Li T, Xie Z. The potential dual effects of anesthetic isoflurane on hypoxia-induced caspase-3 activation and increases in ß-site amyloid precursor protein-cleaving enzyme levels. Anesth Analg. 2011 Jul; 113(1):145-52. PMID: 21519046.
    Citations: 13     Fields:    Translation:HumansCells
  65. Palanisamy A, Baxter MG, Keel PK, Xie Z, Crosby G, Culley DJ. Rats exposed to isoflurane in utero during early gestation are behaviorally abnormal as adults. Anesthesiology. 2011 Mar; 114(3):521-8. PMID: 21307768.
    Citations: 40     Fields:    Translation:Animals
  66. Wu X, Lu Y, Dong Y, Zhang G, Zhang Y, Xu Z, Culley DJ, Crosby G, Marcantonio ER, Tanzi RE, Xie Z. The inhalation anesthetic isoflurane increases levels of proinflammatory TNF-a, IL-6, and IL-1ß. Neurobiol Aging. 2012 Jul; 33(7):1364-78. PMID: 21190757.
    Citations: 102     Fields:    Translation:AnimalsCells
  67. Bittner EA, Yue Y, Xie Z. Brief review: anesthetic neurotoxicity in the elderly, cognitive dysfunction and Alzheimer's disease. Can J Anaesth. 2011 Feb; 58(2):216-23. PMID: 21174183.
    Citations: 30     Fields:    Translation:HumansAnimals
  68. Lu Y, Wu X, Dong Y, Xu Z, Zhang Y, Xie Z. Anesthetic sevoflurane causes neurotoxicity differently in neonatal naïve and Alzheimer disease transgenic mice. Anesthesiology. 2010 Jun; 112(6):1404-16. PMID: 20460993.
    Citations: 72     Fields:    Translation:Animals
  69. Zhang C, Browne A, Divito JR, Stevenson JA, Romano D, Dong Y, Xie Z, Tanzi RE. Amyloid-ß production via cleavage of amyloid-ß protein precursor is modulated by cell density. J Alzheimers Dis. 2010; 22(2):683-984. PMID: 20847415.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  70. Zhang Y, Dong Y, Wu X, Lu Y, Xu Z, Knapp A, Yue Y, Xu T, Xie Z. The mitochondrial pathway of anesthetic isoflurane-induced apoptosis. J Biol Chem. 2010 Feb 05; 285(6):4025-4037. PMID: 20007710.
    Citations: 99     Fields:    Translation:HumansAnimalsCells
  71. Zhen Y, Dong Y, Wu X, Xu Z, Lu Y, Zhang Y, Norton D, Tian M, Li S, Xie Z. Nitrous oxide plus isoflurane induces apoptosis and increases beta-amyloid protein levels. Anesthesiology. 2009 Oct; 111(4):741-52. PMID: 19741497.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  72. Dong Y, Zhang G, Zhang B, Moir RD, Xia W, Marcantonio ER, Culley DJ, Crosby G, Tanzi RE, Xie Z. The common inhalational anesthetic sevoflurane induces apoptosis and increases beta-amyloid protein levels. Arch Neurol. 2009 May; 66(5):620-31. PMID: 19433662.
    Citations: 98     Fields:    Translation:HumansAnimalsCells
  73. Xie Z, Culley DJ, Dong Y, Zhang G, Zhang B, Moir RD, Frosch MP, Crosby G, Tanzi RE. The common inhalation anesthetic isoflurane induces caspase activation and increases amyloid beta-protein level in vivo. Ann Neurol. 2008 Dec; 64(6):618-27. PMID: 19006075.
    Citations: 128     Fields:    Translation:AnimalsCells
  74. Zhang G, Dong Y, Zhang B, Ichinose F, Wu X, Culley DJ, Crosby G, Tanzi RE, Xie Z. Isoflurane-induced caspase-3 activation is dependent on cytosolic calcium and can be attenuated by memantine. J Neurosci. 2008 Apr 23; 28(17):4551-60. PMID: 18434534.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  75. Zhang B, Dong Y, Zhang G, Moir RD, Xia W, Yue Y, Tian M, Culley DJ, Crosby G, Tanzi RE, Xie Z. The inhalation anesthetic desflurane induces caspase activation and increases amyloid beta-protein levels under hypoxic conditions. J Biol Chem. 2008 May 02; 283(18):11866-75. PMID: 18326038.
    Citations: 41     Fields:    Translation:HumansCells
  76. Culley DJ, Xie Z, Crosby G. General anesthetic-induced neurotoxicity: an emerging problem for the young and old? Curr Opin Anaesthesiol. 2007 Oct; 20(5):408-13. PMID: 17873593.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  77. Li A, Xie Z, Dong Y, McKay KM, McKee ML, Tanzi RE. Isolation and characterization of the Drosophila ubiquilin ortholog dUbqln: in vivo interaction with early-onset Alzheimer disease genes. Hum Mol Genet. 2007 Nov 01; 16(21):2626-39. PMID: 17704509.
    Citations: 18     Fields:    Translation:HumansAnimals
  78. Culley DJ, Crosby G, Xie Z, Vacanti CA, Kitz RJ, Zapol WM. Career National Institutes of Health funding and scholarship of chairpersons of academic departments of anesthesiology and surgery. Anesthesiology. 2007 Apr; 106(4):836-42. PMID: 17413922.
    Citations: 2     Fields:    Translation:Humans
  79. Xie Z, Dong Y, Maeda U, Xia W, Tanzi RE. RNAi silencing of the adaptor molecules ShcC and Fe65 differentially affect amyloid precursor protein processing and Ab generation. Journal of Biological Chemistry. 2007; 282:4318 - 4325.
  80. Xie Z, Dong Y, Maeda U, Moir R, Xia W, Culley DJ, Crosby G, Tanzi RE . Inhalation Anesthetic Isoflurane Induces a Vicious Cycle of Apoptosis and Ab generation. Journal of Neuroscience. 2007; 27(6):1247 – 1254.
  81. Li A, Xie Z, Dong D, McKee ML, Reena Patel R, McKay KM, White K, Tanzi RE. Overexpression of Drosophila ubiquilin promotes a “rough” eye phenotype and age-dependent neurodegeneration in the brain. 2007.
  82. Xie Z, Dong Y, Maeda U, Xia W, Tanzi RE. RNA interference silencing of the adaptor molecules ShcC and Fe65 differentially affect amyloid precursor protein processing and Abeta generation. J Biol Chem. 2007 Feb 16; 282(7):4318-4325. PMID: 17170108.
    Citations: 27     Fields:    Translation:HumansCells
  83. Xie Z, Dong Y, Maeda U, Moir R, Inouye SK, Culley DJ, Crosby G, Tanzi RE. Isoflurane-induced apoptosis: a potential pathogenic link between delirium and dementia. J Gerontol A Biol Sci Med Sci. 2006 Dec; 61(12):1300-6. PMID: 17234824.
    Citations: 54     Fields:    Translation:HumansCells
  84. Hiltunen M, Lu A, Thomas AV, Romano DM, Kim M, Jones PB, Xie Z, Kounnas MZ, Wagner SL, Berezovska O, Hyman BT, Tesco G, Bertram L, Tanzi RE. Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretion. J Biol Chem. 2006 Oct 27; 281(43):32240-53. PMID: 16945923.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  85. Culley DJ, Yukhananov RY, Xie Z, Gali RR, Tanzi RE, Crosby G. Altered hippocampal gene expression 2 days after general anesthesia in rats. Eur J Pharmacol. 2006 Nov 07; 549(1-3):71-8. PMID: 16979155.
    Citations: 14     Fields:    Translation:Animals
  86. Jiang Y, Wain JC, Chang AW, Zapol WM, Xie Z. Differential changes of alveolar gas concentrations during anesthetic induction of a patient with an absent right pulmonary artery. Anesth Analg. 2006 Aug; 103(2):312-5, table of contents. PMID: 16861410.
    Citations: 2     Fields:    Translation:Humans
  87. Romano DM, Dong Y, Hiltunen M, Tanzi RE, Xie Z. Artefactual effects of lipid-based cell transfection reagents on AbetaPP processing and Abeta production. Amyloid. 2006 Jun; 13(2):86-92. PMID: 16911962.
    Citations:    Fields:    Translation:HumansCells
  88. Xie Z, Dong Y, Maeda U, Alfille P, Culley DJ, Crosby G, Tanzi RE. The common inhalation anesthetic isoflurane induces apoptosis and increases amyloid beta protein levels. Anesthesiology. 2006 May; 104(5):988-94. PMID: 16645451.
    Citations: 99     Fields:    Translation:HumansCells
  89. Xie Z, Tanzi RE. Alzheimer's disease and post-operative cognitive dysfunction. Exp Gerontol. 2006 Apr; 41(4):346-59. PMID: 16564662.
    Citations: 52     Fields:    Translation:Humans
  90. Tanzi RE, Xie Z. Reduction of Ab levels by intereference of APP binding with adaptor proteins X11a (MINT1) and X11b (MINT2). 2006.
  91. Xie Z, Lanahan J. Geriatric Anesthesia. In Clinical Anesthesia Procedures of Massachusetts General Hospital; Petter Dunn, editor. 2006.
  92. Romano DM, Dong Y, Hiltunen M, Tanzi RE, Xie Z. Effects of lipid cell transfection reagents on APP processing and Ab production. Amyloid: The Journal of Protein Folding Disorders. 2006; 13(2):86-92.
  93. Xie Z, Dong Y, Maeda U, Moir R, Inouye S, Culley DJ, Crosby G, Tanzi RE. Ab fibrillar aggregation inhibitor Congo Red inhibits the apoptosis induced by inhalation anesthetic isoflurane. Journal of Gerontology: Medical Sciences. 2006; 61A(12):1300-1306.
  94. Hiltunen M, Lu A, Thomas AV, Romano DM, Kim M, Jones PB, Xie Z, Kounnas MZ, Wagner SL, Berezovska O, Hyman BT, Tesco G, Bertram L, Tanzi RT. Ubiquilin 1 modulates amyloid precursor protein trafficking and Ab secretion. Journal of Biological Chemistry. 2006; 281:32240-32253.
  95. Culley DJ, Yukhananov RY, Xie Z, Gali RR, Tanzi RE, Crosby G. Hippocampal Gene Expression Is Altered 48 Hours after General Anesthesia in Aged Rats. European Journal of Pharmacology. 2006; 549:71 - 78.
  96. Rubin JP, Xie Z, Davidson C, Rosow CE, Chang Y, May JW. Rapid absorption of tumescent lidocaine above the clavicles: a prospective clinical study. Plast Reconstr Surg. 2005 May; 115(6):1744-51. PMID: 15861085.
    Citations: 3     Fields:    Translation:HumansCells
  97. Xie Z, Romano DM, Tanzi RE. RNA interference-mediated silencing of X11alpha and X11beta attenuates amyloid beta-protein levels via differential effects on beta-amyloid precursor protein processing. J Biol Chem. 2005 Apr 15; 280(15):15413-21. PMID: 15699037.
    Citations: 26     Fields:    Translation:HumansCells
  98. Xie Z, Romano DM, Tanzi, RE. RNAi-mediated silencing of X11a and X11b attenuate Ab levels via differential effects on APP processing. Journal of Biological Chemistry. 2005; 280:15413 – 15421.
  99. Yuki K, Xie Z. Interactions of Maternal Drugs with Anesthesia. In: Manual of Obstetric Anesthesia; May-Pian C. Smith, Lisa R. Leffert, editors. 2005.
  100. Xie Z, Romano DM, Tanzi, RE. Effects of RNAi-mediated silencing of PEN-2, APH-1a, and Nicastrin on wild-type versus FAD mutant forms of presenilin 1. Journal of Molecular Neuroscience. 2005; 25:67-77.
  101. Xie Z, Romano DM, Tanzi RE. Effects of RNAi-mediated silencing of PEN-2, APH-1a, and nicastrin on wild-type vs FAD mutant forms of presenilin 1. J Mol Neurosci. 2005; 25(1):67-77. PMID: 15781968.
    Citations: 15     Fields:    Translation:HumansCells
  102. Xie Z, Romano DM, Kovacs DM, Tanzi RE. Effects of RNA interference-mediated silencing of gamma-secretase complex components on cell sensitivity to caspase-3 activation. J Biol Chem. 2004 Aug 13; 279(33):34130-7. PMID: 15184387.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  103. Xie Z, Romano DM, Kovacs DM, Tanzi, RE . Effects of RNAi-mediated silencing of g-secretase complex components on cell sensitivity to caspase-3 activation. Journal of Biological Chemistry. 2004; 279:34130-34137.
  104. Xie Z, Moir RD, Romano DM, Tesco G, Kovacs DM, Tanzi RE. Hypocapnia Induces Caspase-3 Activation and Increases Ab Production. Neurodegenerative Disease. 2004; 1:29-37.
  105. Xie Z, Moir RD, Romano DM, Tesco G, Kovacs DM, Tanzi RE. Hypocapnia induces caspase-3 activation and increases Abeta production. Neurodegener Dis. 2004; 1(1):29-37. PMID: 16908971.
    Citations: 12     Fields:    Translation:HumansCells
  106. Commissaris RL, Xie Z, Ninichuk PJ, Markovska VL . Multiple Within-Day Conflict Testing Define the Timecourse of Anxiolytic Drug Effects. Pharmacology Biochemistry and Behavior. 1996; 1996(2):369 - 377.
  107. Xie Z, Buckner E, Commissaris RL. Anticonflict Effect of MK-801 in Rats: Time-course and Chronic Treatment Studies. Pharmacology Biochemistry and Behavior. 1995; 51(4):635 - 640.
  108. Xie Z . An Evaluation of Potential Pharmacokinetic & Pharmacodynamic Mechanisms for the Delayed Anxiolytic-Like Effects of Dizocilpine (MK-801) in the Rat. 1994.
  109. Xie Z, Commissaris RL. Anxiolytic-like Effects of the Noncompetitive NMDA antagonist MK-801. Pharmacology Biochemistry and Behavior. 1992; 43:471 - 477.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.