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profileZhongcong Xie, Ph.D., M.D.

TitleHenry Knowles Beecher Professor of Anaesthesia
InstitutionMassachusetts General Hospital
DepartmentAnaesthesia
AddressMassachusetts General Hospital
Anesthesia & Critical Care
55 Fruit St
Boston MA 02114
Phone617/724-9308
Fax617/643-9277
vCardDownload vCard (login for email)

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01HD086977     (XIE, ZHONGCONG)Apr 22, 2016 - Jan 31, 2021
NIH/NICHD
Tau/P-Tau as Biomarkers of Anesthesia- and Surgery-Induced Cognitive Impairment in Young Mice
Role: Principal Investigator

R21AG048600     (XIE, ZHONGCONG)Sep 1, 2015 - May 31, 2017
NIH/NIA
The Role of Brain Beta-Amyloid and Tau Protein in POD and POCD
Role: Principal Investigator

R01AG041274     (XIE, ZHONGCONG)Sep 1, 2012 - Feb 28, 2018
NIH/NIA
Pathogenesis of Postoperative Cognitive Dysfunction
Role: Principal Investigator

R21AG038994     (XIE, ZHONGCONG)Sep 1, 2011 - Aug 31, 2014
NIH/NIA
The Role of Alzheimer's-associated Abeta in POD and POCD
Role: Principal Investigator

R01GM088801     (XIE, ZHONGCONG)Feb 1, 2009 - Dec 31, 2017
NIH/NIGMS
General Anesthesia and Alzheimer's Disease Neuropathogenesis
Role: Principal Investigator

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Lu H, Liufu N, Dong Y, Xu G, Zhang Y, Shu L, Soriano SG, Zheng H, Yu B, Xie Z. Sevoflurane Acts on Ubiquitination-Proteasome Pathway to Reduce Postsynaptic Density 95 Protein Levels in Young Mice. Anesthesiology. 2017 Dec; 127(6):961-975. PMID: 28968276.
    View in: PubMed
  2. Shen S, Lim G, You Z, Ding W, Huang P, Ran C, Doheny J, Caravan P, Tate S, Hu K, Kim H, McCabe M, Huang B, Xie Z, Kwon D, Chen L, Mao J. Gut microbiota is critical for the induction of chemotherapy-induced pain. Nat Neurosci. 2017 Sep; 20(9):1213-1216. PMID: 28714953.
    View in: PubMed
  3. Li C, Dong Y, Chen D, Xie Z, Zhang Y. Mild Hypothermia Attenuates the Anesthetic Isoflurane-Induced Cytotoxicity. Front Cell Neurosci. 2017; 11:15. PMID: 28228717.
    View in: PubMed
  4. Dong Y, Xu Z, Huang L, Zhang Y, Xie Z. Peripheral surgical wounding may induce cognitive impairment through interlukin-6-dependent mechanisms in aged mice. Med Gas Res. 2016 Oct-Dec; 6(4):180-186. PMID: 28217289.
    View in: PubMed
  5. Culley DJ, Flaherty D, Reddy S, Fahey MC, Rudolph J, Huang CC, Liu X, Xie Z, Bader AM, Hyman BT, Blacker D, Crosby G. Preoperative Cognitive Stratification of Older Elective Surgical Patients: A Cross-Sectional Study. Anesth Analg. 2016 Jul; 123(1):186-92. PMID: 27028776; PMCID: PMC4912429 [Available on 07/01/17].
  6. Liang F, Zhang Y, Hong W, Dong Y, Xie Z, Quan Q. Direct Tracking of Amyloid and Tu Dynamics in Neuroblastoma Cells Using Nanoplasmonic Fiber Tip Probes. Nano Lett. 2016 Jul 13; 16(7):3989-94. PMID: 27266855.
    View in: PubMed
  7. Xie Z, Wang H. In Response. Anesth Analg. 2016 Apr; 122(4):1225. PMID: 26991630.
    View in: PubMed
  8. Yuan J, Cui G, Li W, Zhang X, Wang X, Zheng H, Zhang J, Xiang S, Xie Z. Propofol Enhances Hemoglobin-Induced Cytotoxicity in Neurons. Anesth Analg. 2016 Apr; 122(4):1024-30. PMID: 26771264.
    View in: PubMed
  9. Ren Q, Peng M, Dong Y, Zhang Y, Chen M, Yin N, Marcantonio ER, Xie Z. Surgery plus anesthesia induces loss of attention in mice. Front Cell Neurosci. 2015; 9:346. PMID: 26441522; PMCID: PMC4561675.
  10. Wang H, Xu Z, Wu A, Dong Y, Zhang Y, Yue Y, Xie Z. 2-deoxy-D-glucose enhances anesthetic effects in mice. Anesth Analg. 2015 Feb; 120(2):312-9. PMID: 25390277; PMCID: PMC4301982.
  11. Sun Y, Zhang Y, Cheng B, Dong Y, Pan C, Li T, Xie Z. Glucose may attenuate isoflurane-induced caspase-3 activation in H4 human neuroglioma cells. Anesth Analg. 2014 Dec; 119(6):1373-80. PMID: 25068691.
    View in: PubMed
  12. Cheng B, Zhang Y, Wang A, Dong Y, Xie Z. Vitamin C Attenuates Isoflurane-Induced Caspase-3 Activation and Cognitive Impairment. Mol Neurobiol. 2015 Dec; 52(3):1580-1589. PMID: 25367886; PMCID: PMC4418956 [Available on 12/01/16].
  13. Tao G, Zhang J, Zhang L, Dong Y, Yu B, Crosby G, Culley DJ, Zhang Y, Xie Z. Sevoflurane induces tau phosphorylation and glycogen synthase kinase 3ß activation in young mice. Anesthesiology. 2014 Sep; 121(3):510-27. PMID: 24787352; PMCID: PMC4165789.
  14. Yang L, Xin X, Zhang J, Zhang L, Dong Y, Zhang Y, Mao J, Xie Z. Inflammatory pain may induce cognitive impairment through an interlukin-6-dependent and postsynaptic density-95-associated mechanism. Anesth Analg. 2014 Aug; 119(2):471-80. PMID: 24878682; PMCID: PMC4107025.
  15. Li XM, Su F, Ji MH, Zhang GF, Qiu LL, Jia M, Gao J, Xie Z, Yang JJ. Disruption of hippocampal neuregulin 1-ErbB4 signaling contributes to the hippocampus-dependent cognitive impairment induced by isoflurane in aged mice. Anesthesiology. 2014 Jul; 121(1):79-88. PMID: 24589481; PMCID: PMC4062586.
  16. Culley DJ, Snayd M, Baxter MG, Xie Z, Lee IH, Rudolph J, Inouye SK, Marcantonio ER, Crosby G. Systemic inflammation impairs attention and cognitive flexibility but not associative learning in aged rats: possible implications for delirium. Front Aging Neurosci. 2014; 6:107. PMID: 24959140; PMCID: PMC4050637.
  17. Zhang J, Dong Y, Zhou C, Zhang Y, Xie Z. Anesthetic sevoflurane reduces levels of hippocalcin and postsynaptic density protein 95. Mol Neurobiol. 2015; 51(3):853-63. PMID: 24870966.
    View in: PubMed
  18. Xu Z, Dong Y, Wang H, Culley DJ, Marcantonio ER, Crosby G, Tanzi RE, Zhang Y, Xie Z. Peripheral surgical wounding and age-dependent neuroinflammation in mice. PLoS One. 2014; 9(5):e96752. PMID: 24796537; PMCID: PMC4010504.
  19. Xie Z, Swain CA, Ward SA, Zheng H, Dong Y, Sunder N, Burke DW, Escobar D, Zhang Y, Marcantonio ER. Preoperative cerebrospinal fluid ß-Amyloid/Tau ratio and postoperative delirium. Ann Clin Transl Neurol. 2014 May 01; 1(5):319-328. PMID: 24860840.
    View in: PubMed
  20. Sun Y, Cheng B, Dong Y, Li T, Xie Z, Zhang Y. Time-Dependent Effects of Anesthetic Isoflurane on Reactive Oxygen Species Levels in HEK-293 Cells. Brain Sci. 2014 Apr 22; 4(2):311-20. PMID: 24961763; PMCID: PMC4101479.
  21. Zhang Y, Pan C, Wu X, Dong Y, Culley DJ, Crosby G, Li T, Xie Z. Different effects of anesthetic isoflurane on caspase-3 activation and cytosol cytochrome c levels between mice neural progenitor cells and neurons. Front Cell Neurosci. 2014; 8:14. PMID: 24523673; PMCID: PMC3906516.
  22. Xu Z, Dong Y, Wang H, Culley DJ, Marcantonio ER, Crosby G, Tanzi RE, Zhang Y, Xie Z. Age-dependent postoperative cognitive impairment and Alzheimer-related neuropathology in mice. Sci Rep. 2014 Jan 20; 4:3766. PMID: 24441878; PMCID: PMC3895908.
  23. Shao H, Zhang Y, Dong Y, Yu B, Xia W, Xie Z. Chronic treatment with anesthetic propofol improves cognitive function and attenuates caspase activation in both aged and Alzheimer's disease transgenic mice. J Alzheimers Dis. 2014; 41(2):499-513. PMID: 24643139; PMCID: PMC4071129.
  24. Culley DJ, Fahy BG, Xie Z, Lekowski R, Buetler S, Liu X, Cohen NH, Crosby G. Academic productivity of directors of ACGME-accredited residency programs in surgery and anesthesiology. Anesth Analg. 2014 Jan; 118(1):200-5. PMID: 24247229.
    View in: PubMed
  25. Zhang X, Xin X, Dong Y, Zhang Y, Yu B, Mao J, Xie Z. Surgical incision-induced nociception causes cognitive impairment and reduction in synaptic NMDA receptor 2B in mice. J Neurosci. 2013 Nov 06; 33(45):17737-48. PMID: 24198365; PMCID: PMC3818549.
  26. Zhang Y, Dong Y, Zheng H, Shie V, Wang H, Busscher JJ, Yue Y, Xu Z, Xie Z. Sevoflurane inhibits neurogenesis and the Wnt-catenin signaling pathway in mouse neural progenitor cells. Curr Mol Med. 2013 Nov; 13(9):1446-54. PMID: 23971735.
    View in: PubMed
  27. Xie Z. Cancer prognosis: can anesthesia play a role? Anesthesiology. 2013 Sep; 119(3):501-3. PMID: 23756456; PMCID: PMC3750085.
  28. Xie Z, McAuliffe S, Swain CA, Ward SA, Crosby CA, Zheng H, Sherman J, Dong Y, Zhang Y, Sunder N, Burke D, Washicosky KJ, Tanzi RE, Marcantonio ER. Cerebrospinal fluid aß to tau ratio and postoperative cognitive change. Ann Surg. 2013 Aug; 258(2):364-9. PMID: 23732272; PMCID: PMC3880113.
  29. Xie Z. Neuronal vulnerability to anesthesia neurotoxicity depends on age of neurons. Ann Neurol. 2013 Jun; 73(6):686-7. PMID: 23595639; PMCID: PMC3994990.
  30. Dong Y, Wu X, Zhang G, Xu Z, Zhang Y, Gautam V, Kovacs DM, Wu A, Yue Y, Xie Z. Isoflurane facilitates synaptic NMDA receptor endocytosis in mice primary neurons. Curr Mol Med. 2013 May; 13(4):488-98. PMID: 22950384.
    View in: PubMed
  31. Zheng H, Dong Y, Xu Z, Crosby G, Culley DJ, Zhang Y, Xie Z. Sevoflurane anesthesia in pregnant mice induces neurotoxicity in fetal and offspring mice. Anesthesiology. 2013 Mar; 118(3):516-26. PMID: 23314109; PMCID: PMC3580035.
  32. Shen X, Dong Y, Xu Z, Wang H, Miao C, Soriano SG, Sun D, Baxter MG, Zhang Y, Xie Z. Selective anesthesia-induced neuroinflammation in developing mouse brain and cognitive impairment. Anesthesiology. 2013 Mar; 118(3):502-15. PMID: 23314110; PMCID: PMC3580002.
  33. Zhang Y, Xie Z. Anesthetics isoflurane and desflurane differently affect mitochondrial function, learning, and memory. Ann Neurol. 2012 Oct; 72(4):630. PMID: 23109162.
    View in: PubMed
  34. Zhang Y, Dong Y, Xu Z, Xie Z. Propofol and magnesium attenuate isoflurane-induced caspase-3 activation via inhibiting mitochondrial permeability transition pore. Med Gas Res. 2012 Aug 17; 2(1):20. PMID: 22901676; PMCID: PMC3489514.
  35. Xie Z, Xu Z. General anesthetics and ß-amyloid protein. Prog Neuropsychopharmacol Biol Psychiatry. 2013 Dec 02; 47:140-6. PMID: 22918033; PMCID: PMC3510311.
  36. Zhu B, Dong Y, Xu Z, Gompf HS, Ward SA, Xue Z, Miao C, Zhang Y, Chamberlin NL, Xie Z. Sleep disturbance induces neuroinflammation and impairment of learning and memory. Neurobiol Dis. 2012 Dec; 48(3):348-55. PMID: 22776332; PMCID: PMC3461115.
  37. Cooper O, Seo H, Andrabi S, Guardia-Laguarta C, Graziotto J, Sundberg M, McLean JR, Carrillo-Reid L, Xie Z, Osborn T, Hargus G, Deleidi M, Lawson T, Bogetofte H, Perez-Torres E, Clark L, Moskowitz C, Mazzulli J, Chen L, Volpicelli-Daley L, Romero N, Jiang H, Uitti RJ, Huang Z, Opala G, Scarffe LA, Dawson VL, Klein C, Feng J, Ross OA, Trojanowski JQ, Lee VM, Marder K, Surmeier DJ, Wszolek ZK, Przedborski S, Krainc D, Dawson TM, Isacson O. Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease. Sci Transl Med. 2012 Jul 04; 4(141):141ra90. PMID: 22764206; PMCID: PMC3462009.
  38. Dong Y, Wu X, Xu Z, Zhang Y, Xie Z. Anesthetic isoflurane increases phosphorylated tau levels mediated by caspase activation and Aß generation. PLoS One. 2012; 7(6):e39386. PMID: 22745746; PMCID: PMC3379981.
  39. Xie Z, Dong Y, Maeda U, Xia W, Tanzi RE. RNAi-mediated knock-down of Dab and Numb attenuate Aß levels via ?-secretase mediated APP processing. Transl Neurodegener. 2012 Mar 22; 1(1):8. PMID: 23211096; PMCID: PMC3514095.
  40. Zhang Y, Xu Z, Wang H, Dong Y, Shi HN, Culley DJ, Crosby G, Marcantonio ER, Tanzi RE, Xie Z. Anesthetics isoflurane and desflurane differently affect mitochondrial function, learning, and memory. Ann Neurol. 2012 May; 71(5):687-98. PMID: 22368036; PMCID: PMC3942786.
  41. Vlisides P, Xie Z. Neurotoxicity of general anesthetics: an update. Curr Pharm Des. 2012; 18(38):6232-40. PMID: 22762477.
    View in: PubMed
  42. Zhang B, Tian M, Zhen Y, Yue Y, Sherman J, Zheng H, Li S, Tanzi RE, Marcantonio ER, Xie Z. The effects of isoflurane and desflurane on cognitive function in humans. Anesth Analg. 2012 Feb; 114(2):410-5. PMID: 22075020; PMCID: PMC3972614.
  43. Xu Z, Dong Y, Wu X, Zhang J, McAuliffe S, Pan C, Zhang Y, Ichinose F, Yue Y, Xie Z. The potential dual effects of anesthetic isoflurane on Aß-induced apoptosis. Curr Alzheimer Res. 2011 Nov; 8(7):741-52. PMID: 21244349; PMCID: PMC3973025.
  44. Zhang Y, Zhen Y, Dong Y, Xu Z, Yue Y, Golde TE, Tanzi RE, Moir RD, Xie Z. Anesthetic propofol attenuates the isoflurane-induced caspase-3 activation and Aß oligomerization. PLoS One. 2011; 6(11):e27019. PMID: 22069482; PMCID: PMC3206055.
  45. Culley DJ, Boyd JD, Palanisamy A, Xie Z, Kojima K, Vacanti CA, Tanzi RE, Crosby G. Isoflurane decreases self-renewal capacity of rat cultured neural stem cells. Anesthesiology. 2011 Oct; 115(4):754-63. PMID: 21666433; PMCID: PMC3432861.
  46. Zhang J, Dong Y, Xu Z, Zhang Y, Pan C, McAuliffe S, Ichinose F, Yue Y, Liang W, Xie Z. 2-Deoxy-D-glucose attenuates isoflurane-induced cytotoxicity in an in vitro cell culture model of H4 human neuroglioma cells. Anesth Analg. 2011 Dec; 113(6):1468-75. PMID: 21965367; PMCID: PMC3224184.
  47. Dong Y, Xu Z, Zhang Y, McAuliffe S, Wang H, Shen X, Yue Y, Xie Z. RNA interference-mediated silencing of BACE and APP attenuates the isoflurane-induced caspase activation. Med Gas Res. 2011 Apr 28; 1(1):5. PMID: 22146340; PMCID: PMC3191487.
  48. Pan C, Xu Z, Dong Y, Zhang Y, Zhang J, McAuliffe S, Yue Y, Li T, Xie Z. The potential dual effects of anesthetic isoflurane on hypoxia-induced caspase-3 activation and increases in ß-site amyloid precursor protein-cleaving enzyme levels. Anesth Analg. 2011 Jul; 113(1):145-52. PMID: 21519046; PMCID: PMC3123429.
  49. Palanisamy A, Baxter MG, Keel PK, Xie Z, Crosby G, Culley DJ. Rats exposed to isoflurane in utero during early gestation are behaviorally abnormal as adults. Anesthesiology. 2011 Mar; 114(3):521-8. PMID: 21307768; PMCID: PMC3071297.
  50. Wu X, Lu Y, Dong Y, Zhang G, Zhang Y, Xu Z, Culley DJ, Crosby G, Marcantonio ER, Tanzi RE, Xie Z. The inhalation anesthetic isoflurane increases levels of proinflammatory TNF-a, IL-6, and IL-1ß. Neurobiol Aging. 2012 Jul; 33(7):1364-78. PMID: 21190757; PMCID: PMC3117127.
  51. Bittner EA, Yue Y, Xie Z. Brief review: anesthetic neurotoxicity in the elderly, cognitive dysfunction and Alzheimer's disease. Can J Anaesth. 2011 Feb; 58(2):216-23. PMID: 21174183; PMCID: PMC4248669.
  52. Lu Y, Wu X, Dong Y, Xu Z, Zhang Y, Xie Z. Anesthetic sevoflurane causes neurotoxicity differently in neonatal naïve and Alzheimer disease transgenic mice. Anesthesiology. 2010 Jun; 112(6):1404-16. PMID: 20460993; PMCID: PMC2877754.
  53. Zhang C, Browne A, Divito JR, Stevenson JA, Romano D, Dong Y, Xie Z, Tanzi RE. Amyloid-ß production via cleavage of amyloid-ß protein precursor is modulated by cell density. J Alzheimers Dis. 2010; 22(2):683-984. PMID: 20847415; PMCID: PMC3272776.
  54. Zhang Y, Dong Y, Wu X, Lu Y, Xu Z, Knapp A, Yue Y, Xu T, Xie Z. The mitochondrial pathway of anesthetic isoflurane-induced apoptosis. J Biol Chem. 2010 Feb 05; 285(6):4025-37. PMID: 20007710; PMCID: PMC2823544.
  55. Zhen Y, Dong Y, Wu X, Xu Z, Lu Y, Zhang Y, Norton D, Tian M, Li S, Xie Z. Nitrous oxide plus isoflurane induces apoptosis and increases beta-amyloid protein levels. Anesthesiology. 2009 Oct; 111(4):741-52. PMID: 19741497; PMCID: PMC2797570.
  56. Dong Y, Zhang G, Zhang B, Moir RD, Xia W, Marcantonio ER, Culley DJ, Crosby G, Tanzi RE, Xie Z. The common inhalational anesthetic sevoflurane induces apoptosis and increases beta-amyloid protein levels. Arch Neurol. 2009 May; 66(5):620-31. PMID: 19433662; PMCID: PMC2748878.
  57. Xie Z, Culley DJ, Dong Y, Zhang G, Zhang B, Moir RD, Frosch MP, Crosby G, Tanzi RE. The common inhalation anesthetic isoflurane induces caspase activation and increases amyloid beta-protein level in vivo. Ann Neurol. 2008 Dec; 64(6):618-27. PMID: 19006075; PMCID: PMC2612087.
  58. Zhang G, Dong Y, Zhang B, Ichinose F, Wu X, Culley DJ, Crosby G, Tanzi RE, Xie Z. Isoflurane-induced caspase-3 activation is dependent on cytosolic calcium and can be attenuated by memantine. J Neurosci. 2008 Apr 23; 28(17):4551-60. PMID: 18434534; PMCID: PMC3844798.
  59. Zhang B, Dong Y, Zhang G, Moir RD, Xia W, Yue Y, Tian M, Culley DJ, Crosby G, Tanzi RE, Xie Z. The inhalation anesthetic desflurane induces caspase activation and increases amyloid beta-protein levels under hypoxic conditions. J Biol Chem. 2008 May 02; 283(18):11866-75. PMID: 18326038; PMCID: PMC2335348.
  60. Culley DJ, Xie Z, Crosby G. General anesthetic-induced neurotoxicity: an emerging problem for the young and old? Curr Opin Anaesthesiol. 2007 Oct; 20(5):408-13. PMID: 17873593.
    View in: PubMed
  61. Li A, Xie Z, Dong Y, McKay KM, McKee ML, Tanzi RE. Isolation and characterization of the Drosophila ubiquilin ortholog dUbqln: in vivo interaction with early-onset Alzheimer disease genes. Hum Mol Genet. 2007 Nov 01; 16(21):2626-39. PMID: 17704509.
    View in: PubMed
  62. Culley DJ, Crosby G, Xie Z, Vacanti CA, Kitz RJ, Zapol WM. Career National Institutes of Health funding and scholarship of chairpersons of academic departments of anesthesiology and surgery. Anesthesiology. 2007 Apr; 106(4):836-42. PMID: 17413922.
    View in: PubMed
  63. Xie Z, Dong Y, Maeda U, Xia W, Tanzi RE. RNAi silencing of the adaptor molecules ShcC and Fe65 differentially affect amyloid precursor protein processing and Ab generation. Journal of Biological Chemistry. 2007; 282:4318 - 4325.
  64. Xie Z, Dong Y, Maeda U, Moir R, Xia W, Culley DJ, Crosby G, Tanzi RE . Inhalation Anesthetic Isoflurane Induces a Vicious Cycle of Apoptosis and Ab generation. Journal of Neuroscience. 2007; 27(6):1247 – 1254.
  65. Li A, Xie Z, Dong D, McKee ML, Reena Patel R, McKay KM, White K, Tanzi RE. Overexpression of Drosophila ubiquilin promotes a “rough” eye phenotype and age-dependent neurodegeneration in the brain. 2007.
  66. Xie Z, Dong Y, Maeda U, Xia W, Tanzi RE. RNA interference silencing of the adaptor molecules ShcC and Fe65 differentially affect amyloid precursor protein processing and Abeta generation. J Biol Chem. 2007 Feb 16; 282(7):4318-25. PMID: 17170108.
    View in: PubMed
  67. Xie Z, Dong Y, Maeda U, Moir R, Inouye SK, Culley DJ, Crosby G, Tanzi RE. Isoflurane-induced apoptosis: a potential pathogenic link between delirium and dementia. J Gerontol A Biol Sci Med Sci. 2006 Dec; 61(12):1300-6. PMID: 17234824.
    View in: PubMed
  68. Hiltunen M, Lu A, Thomas AV, Romano DM, Kim M, Jones PB, Xie Z, Kounnas MZ, Wagner SL, Berezovska O, Hyman BT, Tesco G, Bertram L, Tanzi RE. Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretion. J Biol Chem. 2006 Oct 27; 281(43):32240-53. PMID: 16945923.
    View in: PubMed
  69. Culley DJ, Yukhananov RY, Xie Z, Gali RR, Tanzi RE, Crosby G. Altered hippocampal gene expression 2 days after general anesthesia in rats. Eur J Pharmacol. 2006 Nov 07; 549(1-3):71-8. PMID: 16979155.
    View in: PubMed
  70. Jiang Y, Wain JC, Chang AW, Zapol WM, Xie Z. Differential changes of alveolar gas concentrations during anesthetic induction of a patient with an absent right pulmonary artery. Anesth Analg. 2006 Aug; 103(2):312-5, table of contents. PMID: 16861410.
    View in: PubMed
  71. Romano DM, Dong Y, Hiltunen M, Tanzi RE, Xie Z. Artefactual effects of lipid-based cell transfection reagents on AbetaPP processing and Abeta production. Amyloid. 2006 Jun; 13(2):86-92. PMID: 16911962.
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  72. Xie Z, Dong Y, Maeda U, Alfille P, Culley DJ, Crosby G, Tanzi RE. The common inhalation anesthetic isoflurane induces apoptosis and increases amyloid beta protein levels. Anesthesiology. 2006 May; 104(5):988-94. PMID: 16645451.
    View in: PubMed
  73. Xie Z, Tanzi RE. Alzheimer's disease and post-operative cognitive dysfunction. Exp Gerontol. 2006 Apr; 41(4):346-59. PMID: 16564662.
    View in: PubMed
  74. Tanzi RE, Xie Z. Reduction of Ab levels by intereference of APP binding with adaptor proteins X11a (MINT1) and X11b (MINT2). 2006.
  75. Xie Z, Lanahan J. Geriatric Anesthesia. In Clinical Anesthesia Procedures of Massachusetts General Hospital; Petter Dunn, editor. 2006.
  76. Romano DM, Dong Y, Hiltunen M, Tanzi RE, Xie Z. Effects of lipid cell transfection reagents on APP processing and Ab production. Amyloid: The Journal of Protein Folding Disorders. 2006; 13(2):86-92.
  77. Xie Z, Dong Y, Maeda U, Moir R, Inouye S, Culley DJ, Crosby G, Tanzi RE. Ab fibrillar aggregation inhibitor Congo Red inhibits the apoptosis induced by inhalation anesthetic isoflurane. Journal of Gerontology: Medical Sciences. 2006; 61A(12):1300-1306.
  78. Hiltunen M, Lu A, Thomas AV, Romano DM, Kim M, Jones PB, Xie Z, Kounnas MZ, Wagner SL, Berezovska O, Hyman BT, Tesco G, Bertram L, Tanzi RT. Ubiquilin 1 modulates amyloid precursor protein trafficking and Ab secretion. Journal of Biological Chemistry. 2006; 281:32240-32253.
  79. Culley DJ, Yukhananov RY, Xie Z, Gali RR, Tanzi RE, Crosby G. Hippocampal Gene Expression Is Altered 48 Hours after General Anesthesia in Aged Rats. European Journal of Pharmacology. 2006; 549:71 - 78.
  80. Rubin JP, Xie Z, Davidson C, Rosow CE, Chang Y, May JW. Rapid absorption of tumescent lidocaine above the clavicles: a prospective clinical study. Plast Reconstr Surg. 2005 May; 115(6):1744-51. PMID: 15861085.
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  81. Xie Z, Romano DM, Tanzi RE. RNA interference-mediated silencing of X11alpha and X11beta attenuates amyloid beta-protein levels via differential effects on beta-amyloid precursor protein processing. J Biol Chem. 2005 Apr 15; 280(15):15413-21. PMID: 15699037.
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  82. Xie Z, Romano DM, Tanzi, RE. RNAi-mediated silencing of X11a and X11b attenuate Ab levels via differential effects on APP processing. Journal of Biological Chemistry. 2005; 280:15413 – 15421.
  83. Yuki K, Xie Z. Interactions of Maternal Drugs with Anesthesia. In: Manual of Obstetric Anesthesia; May-Pian C. Smith, Lisa R. Leffert, editors. 2005.
  84. Xie Z, Romano DM, Tanzi, RE. Effects of RNAi-mediated silencing of PEN-2, APH-1a, and Nicastrin on wild-type versus FAD mutant forms of presenilin 1. Journal of Molecular Neuroscience. 2005; 25:67-77.
  85. Xie Z, Romano DM, Tanzi RE. Effects of RNAi-mediated silencing of PEN-2, APH-1a, and nicastrin on wild-type vs FAD mutant forms of presenilin 1. J Mol Neurosci. 2005; 25(1):67-77. PMID: 15781968.
    View in: PubMed
  86. Xie Z, Romano DM, Kovacs DM, Tanzi RE. Effects of RNA interference-mediated silencing of gamma-secretase complex components on cell sensitivity to caspase-3 activation. J Biol Chem. 2004 Aug 13; 279(33):34130-7. PMID: 15184387.
    View in: PubMed
  87. Xie Z, Romano DM, Kovacs DM, Tanzi, RE . Effects of RNAi-mediated silencing of g-secretase complex components on cell sensitivity to caspase-3 activation. Journal of Biological Chemistry. 2004; 279:34130-34137.
  88. Xie Z, Moir RD, Romano DM, Tesco G, Kovacs DM, Tanzi RE. Hypocapnia Induces Caspase-3 Activation and Increases Ab Production. Neurodegenerative Disease. 2004; 1:29-37.
  89. Xie Z, Moir RD, Romano DM, Tesco G, Kovacs DM, Tanzi RE. Hypocapnia induces caspase-3 activation and increases Abeta production. Neurodegener Dis. 2004; 1(1):29-37. PMID: 16908971.
    View in: PubMed
  90. Commissaris RL, Xie Z, Ninichuk PJ, Markovska VL . Multiple Within-Day Conflict Testing Define the Timecourse of Anxiolytic Drug Effects. Pharmacology Biochemistry and Behavior. 1996; 1996(2):369 - 377.
  91. Xie Z, Buckner E, Commissaris RL. Anticonflict Effect of MK-801 in Rats: Time-course and Chronic Treatment Studies. Pharmacology Biochemistry and Behavior. 1995; 51(4):635 - 640.
  92. Xie Z . An Evaluation of Potential Pharmacokinetic & Pharmacodynamic Mechanisms for the Delayed Anxiolytic-Like Effects of Dizocilpine (MK-801) in the Rat. 1994.
  93. Xie Z, Commissaris RL. Anxiolytic-like Effects of the Noncompetitive NMDA antagonist MK-801. Pharmacology Biochemistry and Behavior. 1992; 43:471 - 477.
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