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Wucherpfennig, Kai
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Kai Wucherpfennig, Ph.D., M.D.
Title
Nancy Lurie Marks Professor of Neurology in the Field of Medical Oncology
Institution
Dana-Farber Cancer Institute
Department
Neurology
Address
Dana-Farber Cancer Institute
Cancer Immunology, Smith 736
1 Jimmy Fund Way
Boston MA 02115
Phone
617/632-3086
Fax
617/632-2662
vCard
Download vCard
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login for email
)
Other Positions
Title
Professor of Immunology
Institution
Harvard Medical School
Department
Immunology
research activities and funding
|
selected publications
|
Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can
login
to make corrections and additions.
Most Recent
|
List All
R01CA251599
(WUCHERPFENNIG, KAI W)
Aug 1, 2020 - Apr 30, 2025
NIH
Targeting of a Major Immune Evasion Pathway in Triple-negative Breast Cancer
Role: Principal Investigator
R01CA234018
(WUCHERPFENNIG, KAI W)
May 15, 2019 - Apr 30, 2023
NIH
Regulators of Cancer Immunotherapy Response
Role: Co-Principal Investigator
R01CA238039
(WUCHERPFENNIG, KAI W)
Mar 1, 2019 - Feb 29, 2024
NIH
Therapeutic Targeting of Immune Evasion from the MICA - NKG2D Pathway
Role: Principal Investigator
T32CA207021
(WUCHERPFENNIG, KAI W)
Jul 13, 2016 - Jun 30, 2021
NIH
Cancer Immunology Training Grant
Role: Principal Investigator
R56AI104730
(WUCHERPFENNIG, KAI W)
Aug 1, 2014 - Jul 31, 2017
NIH
Molecular mechanisms of HLA-DM mediated peptide exchange
Role: Co-Principal Investigator
DP3DK097681
(WUCHERPFENNIG, KAI W)
Sep 15, 2012 - Jun 14, 2017
NIH
Impact of MHC Genotype on Ex Vivo T cell Function in Type 1 Diabetes
Role: Co-Principal Investigator
R01CA173750
(WUCHERPFENNIG, KAI W)
Sep 13, 2012 - Jul 31, 2019
NIH
Reprogramming of T cells for the Treatment of Melanoma
Role: Co-Principal Investigator
R01AI064177
(WUCHERPFENNIG, KAI W)
Apr 1, 2005 - Dec 31, 2011
NIH
TCR Crossreactivity in autoimmune Diseases
Role: Principal Investigator
R01AI057493
(WUCHERPFENNIG, KAI W)
Dec 1, 2003 - Nov 30, 2010
NIH
Mechanisms of Antigen Presentation by MHC class II
Role: Principal Investigator
R01AI054520
(WUCHERPFENNIG, KAI W)
Apr 1, 2003 - Jan 31, 2016
NIH
Structural Determinants of TCR Assembly and Signaling
Role: Principal Investigator
R01NS044914
(WUCHERPFENNIG, KAI W)
Dec 15, 2002 - Jun 30, 2014
NIH
Inhibition of Antigen Presentation in Multiple Sclerosis
Role: Principal Investigator
P41RR015301
(EALICK, STEVEN E)
Jun 15, 2001 - Mar 31, 2013
NIH/NCRR
An Undulator Resource for Structural Biology
Role: Co-Principal Investigator
P01AI045757
(WUCHERPFENNIG, KAI W)
Sep 30, 1999 - Aug 31, 2020
NIH
Antigen Presentation and T cell Programming in Human Autoimmune Diseases
Role: Principal Investigator
R01NS039096
(WUCHERPFENNIG, KAI W)
Jul 1, 1999 - Jun 30, 2004
NIH
SPECIFICITY AND DEGENERACY OF AUTOREACTIVE T CELL RECEPT
Role: Principal Investigator
P41RR012408
(SWEET, ROBERT M)
Sep 30, 1998 - Jun 30, 2013
NIH/NCRR
Macromolecular Crystallography at the National Synchrotron Light Source
Role: Co-Principal Investigator
R21AI041641
(WUCHERPFENNIG, KAI W)
Sep 30, 1997 - Sep 29, 1999
NIH
VIRAL PEPTIDES THAT INDUCE T CELL MEDIATED AUTOIMMUNITY
Role: Principal Investigator
R01AI042316
(WUCHERPFENNIG, KAI W)
Sep 1, 1997 - Aug 31, 2002
NIH
MOLECULAR MECHANISMS OF MHC LINKED SUSCEPTIBILITY
Role: Principal Investigator
P01AI039619
(WUCHERPFENNIG, KAI W)
Sep 30, 1996 - Aug 31, 2001
NIH/NIAID
CORE--BIOCHEMISTRY LABORATORY
Role: Principal Investigator
Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can
login
to make corrections and additions.
Newest
|
Oldest
|
Most Cited
|
Most Discussed
|
Timeline
|
Field Summary
|
Plain Text
PMC Citations
indicate the number of times the publication was cited by articles in PubMed Central, and the
Altmetric
score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.)
Fields
are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
Translation
tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
Ito Y, Pan D, Zhang W, Zhang X, Juan TY, Pyrdol JW, Kyrysyuk O, Doench JG, Liu XS,
Wucherpfennig KW
. Addressing Tumor Heterogeneity by Sensitizing Resistant Cancer Cells to T cell-secreted Cytokines. Cancer Discov. 2023 Feb 22.
PMID:
36811466
.
Citations:
Fields:
Neo
Neoplasms
Hagel KR,
Arafeh R
, Gang S, Arnoff TE, Larson RC, Doench JG, Mathewson ND,
Wucherpfennig KW
,
Maus MV
,
Hahn WC
. Systematic Interrogation of Tumor Cell Resistance to Chimeric Antigen Receptor T-cell Therapy in Pancreatic Cancer. Cancer Res. 2023 02 15; 83(4):613-625.
PMID:
36548402
; PMCID:
PMC9929516
.
Citations:
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Xie W,
Wucherpfennig K
, Patel DJ. A structural platform for B cell receptor signaling. Cell Res. 2023 02; 33(2):95-96.
PMID:
36109597
; PMCID:
PMC9476432
.
Citations:
Fields:
Cel
Cell Biology
Translation:
Cells
Liu Y, Adu-Berchie K, Brockman JM, Pezone M, Zhang DKY, Zhou J, Pyrdol JW, Wang H,
Wucherpfennig KW
, Mooney DJ. Cytokine conjugation to enhance T cell therapy. Proc Natl Acad Sci U S A. 2023 01 03; 120(1):e2213222120.
PMID:
36577059
; PMCID:
PMC9910457
.
Citations:
Fields:
Sci
Science
Translation:
Humans
Cells
Aleckovic M,
Cristea S
, Gil Del Alcazar CR, Yan P, Ding L, Krop ED, Harper NW, Rojas Jimenez E, Lu D, Gulvady AC,
Foidart P
,
Seehawer M
, Diciaccio B, Murphy KC, Pyrdol J, Anand J, Garza K,
Wucherpfennig KW
, Tamimi RM,
Michor F
,
Polyak K
. Breast cancer prevention by short-term inhibition of TGFß signaling. Nat Commun. 2022 12 07; 13(1):7558.
PMID:
36476730
; PMCID:
PMC9729304
.
Citations:
Fields:
Bio
Biology
Sci
Science
Translation:
Humans
Animals
Kyrysyuk O,
Wucherpfennig KW
. Designing Cancer Immunotherapies That Engage T Cells and NK Cells. Annu Rev Immunol. 2022 Nov 29.
PMID:
36446137
.
Citations:
1
Fields:
All
Allergy and Immunology
Notarangelo G, Spinelli JB, Perez EM,
Baker GJ
,
Kurmi K
, Elia I,
Stopka SA
, Baquer G, Lin JR,
Golby AJ
, Joshi S, Baron HF,
Drijvers JM
,
Georgiev P
, Ringel AE, Zaganjor E, McBrayer SK,
Sorger PK
,
Sharpe AH
,
Wucherpfennig KW
,
Santagata S
, Agar NYR, Suvà ML,
Haigis MC
. Oncometabolite d-2HG alters T cell metabolism to impair CD8+ T cell function. Science. 2022 09 30; 377(6614):1519-1529.
PMID:
36173860
; PMCID:
PMC9629749
.
Citations:
4
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Vining KH, Marneth AE, Adu-Berchie K, Grolman JM, Tringides CM, Liu Y,
Wong WJ
,
Pozdnyakova O
, Severgnini M, Stafford A, Duda GN,
Hodi FS
,
Mullally A
,
Wucherpfennig KW
, Mooney DJ. Mechanical checkpoint regulates monocyte differentiation in fibrotic niches. Nat Mater. 2022 08; 21(8):939-950.
PMID:
35817965
.
Citations:
4
Fields:
Che
Chemistry
Sci
Science
Translation:
Humans
Animals
Cells
Luoma AM,
Suo S
, Wang Y, Gunasti L, Porter CBM, Nabilsi N, Tadros J, Ferretti AP, Liao S, Gurer C, Chen YH, Criscitiello S, Ricker CA, Dionne D, Rozenblatt-Rosen O,
Uppaluri R
,
Haddad RI
, Ashenberg O, Regev A,
Van Allen EM
, MacBeath G,
Schoenfeld JD
,
Wucherpfennig KW
. Tissue-resident memory and circulating T cells are early responders to pre-surgical cancer immunotherapy. Cell. 2022 08 04; 185(16):2918-2935.e29.
PMID:
35803260
; PMCID:
PMC9508682
.
Citations:
14
Fields:
Cel
Cell Biology
Translation:
Humans
Cells
Badrinath S, Dellacherie MO, Li A,
Zheng S
, Zhang X, Sobral M, Pyrdol JW, Smith KL, Lu Y, Haag S, Ijaz H, Connor-Stroud F, Kaisho T, Dranoff G, Yuan GC, Mooney DJ,
Wucherpfennig KW
. A vaccine targeting resistant tumours by dual T cell plus NK cell attack. Nature. 2022 06; 606(7916):992-998.
PMID:
35614223
.
Citations:
14
Fields:
Sci
Science
Translation:
Humans
Cells
Qiu X
, Boufaied N, Hallal T, Feit A, de Polo A, Luoma AM, Alahmadi W, Larocque J, Zadra G, Xie Y,
Gu S
, Tang Q, Zhang Y, Syamala S,
Seo JH
, Bell C, O'Connor E, Liu Y, Schaeffer EM, Jeffrey Karnes R, Weinmann S, Davicioni E, Morrissey C,
Cejas P
, Ellis L,
Loda M
,
Wucherpfennig KW
,
Pomerantz MM
, Spratt DE, Corey E,
Freedman ML
, Shirley Liu X, Brown M,
Long HW
, Labbé DP. MYC drives aggressive prostate cancer by disrupting transcriptional pause release at androgen receptor targets. Nat Commun. 2022 05 13; 13(1):2559.
PMID:
35562350
; PMCID:
PMC9106722
.
Citations:
13
Fields:
Bio
Biology
Sci
Science
Translation:
Humans
Cells
Marx S,
Godicelj A
,
Wucherpfennig KW
. A Conceptual Framework for Inducing T Cell-Mediated Immunity Against Glioblastoma. Semin Immunopathol. 2022 09; 44(5):697-707.
PMID:
35505129
; PMCID:
PMC9942346
.
Citations:
Fields:
All
Allergy and Immunology
Pat
Pathology
Translation:
Humans
Pan R
,
Ryan J
, Pan D,
Wucherpfennig KW
,
Letai A
. Augmenting NK cell-based immunotherapy by targeting mitochondrial apoptosis. Cell. 2022 04 28; 185(9):1521-1538.e18.
PMID:
35447071
; PMCID:
PMC9097966
.
Citations:
7
Fields:
Cel
Cell Biology
Translation:
Cells
Baldominos P, Barbera-Mourelle A, Barreiro O, Huang Y, Wight A, Cho JW, Zhao X, Estivill G, Adam I,
Sanchez X
, McCarthy S, Schaller J, Khan Z, Ruzo A, Pastorello R,
Richardson ET
,
Dillon D
, Montero-Llopis P, Barroso-Sousa R, Forman J, Shukla SA,
Tolaney SM
,
Mittendorf EA
,
von Andrian UH
,
Wucherpfennig KW
,
Hemberg M
,
Agudo J
. Quiescent cancer cells resist T cell attack by forming an immunosuppressive niche. Cell. 2022 05 12; 185(10):1694-1708.e19.
PMID:
35447074
.
Citations:
23
Fields:
Cel
Cell Biology
Translation:
Humans
Cells
Oliviero B, Varchetta S, Mele D, Pessino G, Maiello R, Falleni M, Tosi D, Donadon M, Soldani C, Franceschini B, Torzilli G, Piccolo G, Barabino M, Opocher E, Maestri M, Bernuzzi S,
Wucherpfennig KW
, Mondelli MU, Mantovani S. MICA/B-targeted antibody promotes NK cell-driven tumor immunity in patients with intrahepatic cholangiocarcinoma. Oncoimmunology. 2022; 11(1):2035919.
PMID:
35223192
; PMCID:
PMC8865231
.
Citations:
2
Fields:
All
Allergy and Immunology
Neo
Neoplasms
Translation:
Humans
Cells
Alves da Silva PH, Xing S, Kotini AG, Papapetrou EP, Song X,
Wucherpfennig KW
, Mascarenhas J, Ferrari de Andrade L. MICA/B antibody induces macrophage-mediated immunity against acute myeloid leukemia. Blood. 2022 01 13; 139(2):205-216.
PMID:
34359073
; PMCID:
PMC8777466
.
Citations:
4
Fields:
Hem
Hematology
Translation:
Humans
Animals
Cells
Jiang P, Zhang Y, Ru B, Yang Y, Vu T, Paul R, Mirza A, Altan-Bonnet G, Liu L, Ruppin E, Wakefield L,
Wucherpfennig KW
. Systematic investigation of cytokine signaling activity at the tissue and single-cell levels. Nat Methods. 2021 10; 18(10):1181-1191.
PMID:
34594031
; PMCID:
PMC8493809
.
Citations:
16
Fields:
Cli
Clinical Laboratory Techniques
Translation:
Humans
Cells
Hara T
, Chanoch-Myers R, Mathewson ND, Myskiw C, Atta L, Bussema L, Eichhorn SW, Greenwald AC, Kinker GS, Rodman C,
Gonzalez Castro LN
,
Wakimoto H
, Rozenblatt-Rosen O, Zhuang X, Fan J, Hunter T, Verma IM,
Wucherpfennig KW
, Regev A, Suvà ML, Tirosh I. Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma. Cancer Cell. 2021 06 14; 39(6):779-792.e11.
PMID:
34087162
; PMCID:
PMC8366750
.
Citations:
96
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Roehle K,
Qiang L
, Ventre KS, Heid D,
Ali LR
, Lenehan P, Heckler M, Crowley SJ, Stump CT, Ro G, Godicelj A, Bhuiyan AM,
Yang A
, Quiles Del Rey M, Biary T, Luoma AM, Bruck PT, Tegethoff JF, Nopper SL, Li J, Byrne KT, Pelletier M,
Wucherpfennig KW
, Stanger BZ, Akin JJ,
Mancias JD
,
Agudo J
,
Dougan M
,
Dougan SK
. cIAP1/2 antagonism eliminates MHC class I-negative tumors through T cell-dependent reprogramming of mononuclear phagocytes. Sci Transl Med. 2021 05 19; 13(594).
PMID:
34011631
; PMCID:
PMC8406785
.
Citations:
5
Fields:
Med
Medicine (General)
Sci
Science
Translation:
Humans
Animals
Cells
Heckler M,
Ali LR
, Clancy-Thompson E,
Qiang L
, Ventre KS, Lenehan P, Roehle K, Luoma A, Boelaars K, Peters V, McCreary J, Boschert T, Wang ES,
Suo S
, Marangoni F,
Mempel TR
,
Long HW
,
Wucherpfennig KW
,
Dougan M
, Gray NS, Yuan GC, Goel S,
Tolaney SM
,
Dougan SK
. Inhibition of CDK4/6 Promotes CD8 T-cell Memory Formation. Cancer Discov. 2021 10; 11(10):2564-2581.
PMID:
33941591
; PMCID:
PMC8487897
.
Citations:
21
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Kumar S, Zeng Z, Bagati A, Tay RE, Sanz LA, Hartono SR, Ito Y, Abderazzaq F,
Hatchi E
, Jiang P, Cartwright ANR, Olawoyin O, Mathewson ND, Pyrdol JW, Li MZ, Doench JG, Booker MA, Tolstorukov MY,
Elledge SJ
, Chédin F, Liu XS,
Wucherpfennig KW
. CARM1 Inhibition Enables Immunotherapy of Resistant Tumors by Dual Action on Tumor Cells and T Cells. Cancer Discov. 2021 08; 11(8):2050-2071.
PMID:
33707234
; PMCID:
PMC8338742
.
Citations:
14
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Dougan M
, Luoma AM,
Dougan SK
,
Wucherpfennig KW
. Understanding and treating the inflammatory adverse events of cancer immunotherapy. Cell. 2021 03 18; 184(6):1575-1588.
PMID:
33675691
; PMCID:
PMC7979511
.
Citations:
23
Fields:
Cel
Cell Biology
Translation:
Humans
Animals
Cells
Frangieh CJ, Melms JC, Thakore PI, Geiger-Schuller KR, Ho P, Luoma AM, Cleary B, Jerby-Arnon L, Malu S, Cuoco MS, Zhao M, Ager CR, Rogava M, Hovey L,
Rotem A
, Bernatchez C,
Wucherpfennig KW
,
Johnson BE
, Rozenblatt-Rosen O, Schadendorf D, Regev A, Izar B. Multimodal pooled Perturb-CITE-seq screens in patient models define mechanisms of cancer immune evasion. Nat Genet. 2021 03; 53(3):332-341.
PMID:
33649592
; PMCID:
PMC8376399
.
Citations:
31
Fields:
Gen
Genetics
Translation:
Humans
Cells
Mathewson ND, Ashenberg O, Tirosh I,
Gritsch S
, Perez EM, Marx S, Jerby-Arnon L, Chanoch-Myers R,
Hara T
, Richman AR, Ito Y, Pyrdol J, Friedrich M, Schumann K, Poitras MJ, Gokhale PC,
Gonzalez Castro LN
, Shore ME, Hebert CM, Shaw B, Cahill HL, Drummond M, Zhang W, Olawoyin O,
Wakimoto H
, Rozenblatt-Rosen O, Brastianos PK, Liu XS,
Jones PS
,
Cahill DP
,
Frosch MP
,
Louis DN
,
Freeman GJ
,
Ligon KL
, Marson A,
Chiocca EA
,
Reardon DA
, Regev A, Suvà ML,
Wucherpfennig KW
. Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis. Cell. 2021 03 04; 184(5):1281-1298.e26.
PMID:
33592174
; PMCID:
PMC7935772
.
Citations:
83
Fields:
Cel
Cell Biology
Translation:
Animals
Cells
Cartwright ANR,
Suo S
, Badrinath S, Kumar S, Melms J, Luoma A, Bagati A, Saadatpour A, Izar B, Yuan GC,
Wucherpfennig KW
. Immunosuppressive Myeloid Cells Induce Nitric Oxide-Dependent DNA Damage and p53 Pathway Activation in CD8+ T Cells. Cancer Immunol Res. 2021 04; 9(4):470-485.
PMID:
33514509
.
Citations:
6
Fields:
All
Allergy and Immunology
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Jerby-Arnon L, Neftel C, Shore ME, Weisman HR, Mathewson ND, McBride MJ, Haas B, Izar B,
Volorio A
, Boulay G, Cironi L, Richman AR, Broye LC, Gurski JM, Luo CC, Mylvaganam R, Nguyen L, Mei S, Melms JC, Georgescu C,
Cohen O
, Buendia-Buendia JE, Segerstolpe A, Sud M, Cuoco MS, Labes D,
Gritsch S
, Zollinger DR, Ortogero N, Beechem JM, Petur Nielsen G,
Chebib I
, Nguyen-Ngoc T, Montemurro M,
Cote GM
,
Choy E
, Letovanec I, Cherix S,
Wagle N
,
Sorger PK
, Haynes AB,
Mullen JT
, Stamenkovic I,
Rivera MN
,
Kadoch C
,
Wucherpfennig KW
, Rozenblatt-Rosen O, Suvà ML, Riggi N, Regev A. Opposing immune and genetic mechanisms shape oncogenic programs in synovial sarcoma. Nat Med. 2021 02; 27(2):289-300.
PMID:
33495604
; PMCID:
PMC8817899
.
Citations:
24
Fields:
Med
Medicine (General)
Mol
Molecular Biology
Translation:
Humans
Cells
Hu Z, Leet DE, Allesøe RL,
Oliveira G
, Li S, Luoma AM, Liu J, Forman J, Huang T, Iorgulescu JB, Holden R, Sarkizova S, Gohil SH, Redd RA, Sun J, Elagina L, Giobbie-Hurder A, Zhang W, Peter L, Ciantra Z,
Rodig S
, Olive O, Shetty K, Pyrdol J, Uduman M, Lee PC, Bachireddy P,
Buchbinder EI
,
Yoon CH
,
Neuberg D
, Pentelute BL,
Hacohen N
, Livak KJ, Shukla SA, Olsen LR,
Barouch DH
,
Wucherpfennig KW
,
Fritsch EF
,
Keskin DB
,
Wu CJ
,
Ott PA
. Personal neoantigen vaccines induce persistent memory T cell responses and epitope spreading in patients with melanoma. Nat Med. 2021 03; 27(3):515-525.
PMID:
33479501
; PMCID:
PMC8273876
.
Citations:
93
Fields:
Med
Medicine (General)
Mol
Molecular Biology
Translation:
Humans
Bagati A, Kumar S, Jiang P, Pyrdol J, Zou AE,
Godicelj A
, Mathewson ND, Cartwright ANR,
Cejas P
, Brown M, Giobbie-Hurder A,
Dillon D
,
Agudo J
,
Mittendorf EA
, Liu XS,
Wucherpfennig KW
. Integrin avß6-TGFß-SOX4 Pathway Drives Immune Evasion in Triple-Negative Breast Cancer. Cancer Cell. 2021 01 11; 39(1):54-67.e9.
PMID:
33385331
; PMCID:
PMC7855651
.
Citations:
40
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Choi IK, Wang Z, Ke Q, Hong M,
Paul DW
, Fernandes SM, Hu Z, Stevens J,
Guleria I
, Kim HJ,
Cantor H
,
Wucherpfennig KW
,
Brown JR
,
Ritz J
,
Zhang B
. Mechanism of EBV inducing anti-tumour immunity and its therapeutic use. Nature. 2021 02; 590(7844):157-162.
PMID:
33361812
.
Citations:
23
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Schoenfeld JD
,
Hanna GJ
,
Jo VY
, Rawal B, Chen YH, Catalano PS, Lako A, Ciantra Z, Weirather JL, Criscitiello S, Luoma A, Chau N, Lorch J, Kass JI,
Annino D
,
Goguen L
, Desai A, Ross B,
Shah HJ
,
Jacene HA
,
Margalit DN
,
Tishler RB
,
Wucherpfennig KW
,
Rodig SJ
,
Uppaluri R
,
Haddad RI
. Neoadjuvant Nivolumab or Nivolumab Plus Ipilimumab in Untreated Oral Cavity Squamous Cell Carcinoma: A Phase 2 Open-Label Randomized Clinical Trial. JAMA Oncol. 2020 10 01; 6(10):1563-1570.
PMID:
32852531
; PMCID:
PMC7453348
.
Citations:
79
Fields:
Neo
Neoplasms
Translation:
Humans
CT
Clinical Trials
Shi S, Gu S, Han T, Zhang W, Huang L, Li Z, Pan D,
Fu J
, Ge J, Brown M, Zhang P, Jiang P,
Wucherpfennig KW
, Liu XS. Inhibition of MAN2A1 Enhances the Immune Response to Anti-PD-L1 in Human Tumors. Clin Cancer Res. 2020 11 15; 26(22):5990-6002.
PMID:
32723834
.
Citations:
15
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Gojo J,
Englinger B
, Jiang L, Hübner JM, Shaw ML, Hack OA, Madlener S, Kirchhofer D,
Liu I
, Pyrdol J,
Hovestadt V
,
Mazzola E
, Mathewson ND,
Trissal M
, Lötsch D, Dorfer C, Haberler C, Halfmann A, Mayr L, Peyrl A, Geyeregger R, Schwalm B, Mauermann M, Pajtler KW, Milde T, Shore ME, Geduldig JE, Pelton K, Czech T, Ashenberg O,
Wucherpfennig KW
, Rozenblatt-Rosen O,
Alexandrescu S
,
Ligon KL
, Pfister SM, Regev A, Slavc I, Berger W, Suvà ML, Kool M,
Filbin MG
. Single-Cell RNA-Seq Reveals Cellular Hierarchies and Impaired Developmental Trajectories in Pediatric Ependymoma. Cancer Cell. 2020 07 13; 38(1):44-59.e9.
PMID:
32663469
.
Citations:
39
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Tay RE, Olawoyin O,
Cejas P
, Xie Y,
Meyer CA
, Ito Y, Weng QY, Fisher DE,
Long HW
, Brown M, Kim HJ,
Wucherpfennig KW
. Correction: Hdac3 is an epigenetic inhibitor of the cytotoxicity program in CD8 T cells. J Exp Med. 2020 07 06; 217(7).
PMID:
32441763
; PMCID:
PMC7336308
.
Citations:
2
Fields:
All
Allergy and Immunology
Med
Medicine (General)
Tay RE, Olawoyin O,
Cejas P
, Xie Y,
Meyer CA
, Ito Y, Weng QY, Fisher DE,
Long HW
, Brown M, Kim HJ,
Wucherpfennig KW
. Hdac3 is an epigenetic inhibitor of the cytotoxicity program in CD8 T cells. J Exp Med. 2020 07 06; 217(7).
PMID:
32374402
.
Citations:
15
Fields:
All
Allergy and Immunology
Med
Medicine (General)
Translation:
Animals
Cells
Luoma AM,
Suo S
,
Williams HL
, Sharova T, Sullivan K, Manos M, Bowling P,
Hodi FS
, Rahma O, Sullivan RJ,
Boland GM
,
Nowak JA
,
Dougan SK
,
Dougan M
, Yuan GC,
Wucherpfennig KW
. Molecular Pathways of Colon Inflammation Induced by Cancer Immunotherapy. Cell. 2020 08 06; 182(3):655-671.e22.
PMID:
32603654
.
Citations:
100
Fields:
Cel
Cell Biology
Translation:
Humans
Cells
Wang H, Sobral MC, Zhang DKY, Cartwright AN, Li AW, Dellacherie MO, Tringides CM, Koshy ST,
Wucherpfennig KW
, Mooney DJ. Metabolic labeling and targeted modulation of dendritic cells. Nat Mater. 2020 11; 19(11):1244-1252.
PMID:
32424368
; PMCID:
PMC7748064
.
Citations:
17
Fields:
Che
Chemistry
Sci
Science
Translation:
Humans
Cells
Shu S, Wu HJ,
Ge JY
, Zeid R, Harris IS,
Jovanovic B
, Murphy K, Wang B,
Qiu X
, Endress JE, Reyes J, Lim K,
Font-Tello A
, Syamala S, Xiao T, Reddy Chilamakuri CS, Papachristou EK, D'Santos C, Anand J, Hinohara K, Li W, McDonald TO, Luoma A, Modiste RJ, Nguyen QD, Michel B,
Cejas P
,
Kadoch C
, Jaffe JD,
Wucherpfennig KW
, Qi J, Liu XS,
Long H
, Brown M, Carroll JS,
Brugge JS
, Bradner J,
Michor F
,
Polyak K
. Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer. Mol Cell. 2020 06 18; 78(6):1096-1113.e8.
PMID:
32416067
.
Citations:
42
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Ge JY
, Shu S,
Kwon M
,
Jovanovic B
, Murphy K, Gulvady A,
Fassl A
,
Trinh A
,
Kuang Y
, Heavey GA, Luoma A,
Paweletz C
, Thorner AR,
Wucherpfennig KW
, Qi J, Brown M, Sicinski P, McDonald TO,
Pellman D
,
Michor F
,
Polyak K
. Acquired resistance to combined BET and CDK4/6 inhibition in triple-negative breast cancer. Nat Commun. 2020 05 11; 11(1):2350.
PMID:
32393766
; PMCID:
PMC7214447
.
Citations:
21
Fields:
Bio
Biology
Sci
Science
Translation:
Animals
Cells
Ferrari de Andrade L, Kumar S, Luoma AM, Ito Y, Alves da Silva PH, Pan D, Pyrdol JW,
Yoon CH
,
Wucherpfennig KW
. Inhibition of MICA and MICB Shedding Elicits NK-Cell-Mediated Immunity against Tumors Resistant to Cytotoxic T Cells. Cancer Immunol Res. 2020 06; 8(6):769-780.
PMID:
32209637
.
Citations:
29
Fields:
All
Allergy and Immunology
Neo
Neoplasms
Translation:
Humans
Animals
Cells
McCarthy N
,
Manieri E
, Storm EE, Saadatpour A, Luoma AM, Kapoor VN, Madha S, Gaynor LT, Cox C, Keerthivasan S,
Wucherpfennig K
, Yuan GC, de Sauvage FJ, Turley SJ,
Shivdasani RA
. Distinct Mesenchymal Cell Populations Generate the Essential Intestinal BMP Signaling Gradient. Cell Stem Cell. 2020 03 05; 26(3):391-402.e5.
PMID:
32084389
.
Citations:
86
Fields:
Cel
Cell Biology
Translation:
Cells
Murata K, Jadhav U, Madha S, van Es J, Dean J, Cavazza A,
Wucherpfennig K
,
Michor F
, Clevers H,
Shivdasani RA
. Ascl2-Dependent Cell Dedifferentiation Drives Regeneration of Ablated Intestinal Stem Cells. Cell Stem Cell. 2020 03 05; 26(3):377-390.e6.
PMID:
32084390
.
Citations:
66
Fields:
Cel
Cell Biology
Translation:
Cells
Jadhav U,
Manieri E
, Nalapareddy K, Madha S, Chakrabarti S,
Wucherpfennig K
, Barefoot M,
Shivdasani RA
. Replicational Dilution of H3K27me3 in Mammalian Cells and the Role of Poised Promoters. Mol Cell. 2020 04 02; 78(1):141-151.e5.
PMID:
32027840
.
Citations:
28
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Melms JC, Vallabhaneni S,
Mills CE
,
Yapp C
, Chen JY,
Morelli E
, Waszyk P, Kumar S, Deming D, Moret N, Rodriguez S, Subramanian K, Rogava M, Cartwright ANR, Luoma A, Mei S, Brinker TJ,
Miller DM
,
Spektor A
, Schadendorf D, Riggi N,
Wucherpfennig KW
,
Sorger PK
, Izar B. Inhibition of Haspin Kinase Promotes Cell-Intrinsic and Extrinsic Antitumor Activity. Cancer Res. 2020 02 15; 80(4):798-810.
PMID:
31882401
; PMCID:
PMC7029677
.
Citations:
9
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
de Andrade LF, Lu Y, Luoma A, Ito Y, Pan D, Pyrdol JW,
Yoon CH
, Yuan GC,
Wucherpfennig KW
. Discovery of specialized NK cell populations infiltrating human melanoma metastases. JCI Insight. 2019 12 05; 4(23).
PMID:
31801909
; PMCID:
PMC6962021
.
Citations:
38
Fields:
Med
Medicine (General)
Translation:
Humans
Cells
Alspach E, Lussier DM, Miceli AP, Kizhvatov I, DuPage M, Luoma AM, Meng W, Lichti CF, Esaulova E, Vomund AN, Runci D, Ward JP, Gubin MM, Medrano RFV, Arthur CD, White JM, Sheehan KCF, Chen A,
Wucherpfennig KW
, Jacks T, Unanue ER, Artyomov MN, Schreiber RD. MHC-II neoantigens shape tumour immunity and response to immunotherapy. Nature. 2019 10; 574(7780):696-701.
PMID:
31645760
; PMCID:
PMC6858572
.
Citations:
290
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Kula T
, Dezfulian MH, Wang CI, Abdelfattah NS, Hartman ZC,
Wucherpfennig KW
, Lyerly HK,
Elledge SJ
. T-Scan: A Genome-wide Method for the Systematic Discovery of T Cell Epitopes. Cell. 2019 08 08; 178(4):1016-1028.e13.
PMID:
31398327
.
Citations:
71
Fields:
Cel
Cell Biology
Translation:
Humans
Cells
Janiszewska M, Tabassum DP, Castaño Z,
Cristea S
, Yamamoto KN, Kingston NL, Murphy KC, Shu S, Harper NW, Del Alcazar CG, Aleckovic M, Ekram MB,
Cohen O
, Kwak M, Qin Y, Laszewski T, Luoma A, Marusyk A,
Wucherpfennig KW
,
Wagle N
, Fan R,
Michor F
,
McAllister SS
,
Polyak K
. Subclonal cooperation drives metastasis by modulating local and systemic immune microenvironments. Nat Cell Biol. 2019 07; 21(7):879-888.
PMID:
31263265
.
Citations:
68
Fields:
Cel
Cell Biology
Translation:
Humans
Animals
Cells
Hu X, Zhang J, Wang J, Fu J, Li T, Zheng X, Wang B,
Gu S
, Jiang P, Fan J, Ying X, Zhang J,
Carroll MC
,
Wucherpfennig KW
,
Hacohen N
, Zhang F, Zhang P, Liu JS, Li B, Liu XS. Publisher Correction: Landscape of B cell immunity and related immune evasion in human cancers. Nat Genet. 2019 Jun; 51(6):1068.
PMID:
31101897
.
Citations:
2
Fields:
Gen
Genetics
Chan LL,
Wucherpfennig KW
, de Andrade LF. Visualization and quantification of NK cell-mediated cytotoxicity over extended time periods by image cytometry. J Immunol Methods. 2019 06; 469:47-51.
PMID:
30951701
.
Citations:
7
Fields:
All
Allergy and Immunology
Cli
Clinical Laboratory Techniques
Translation:
Humans
Cells
Grootjans J, Krupka N, Hosomi S,
Matute JD
, Hanley T, Saveljeva S,
Gensollen T
, Heijmans J, Li H, Limenitakis JP, Ganal-Vonarburg SC,
Suo S
, Luoma AM, Shimodaira Y,
Duan J
, Shih DQ, Conner ME,
Glickman JN
, Fuhler GM, Palm NW, de Zoete MR, van der Woude CJ, Yuan GC,
Wucherpfennig KW
, Targan SR, Rosenstiel P, Flavell RA, McCoy KD, Macpherson AJ, Kaser A,
Blumberg RS
. Epithelial endoplasmic reticulum stress orchestrates a protective IgA response. Science. 2019 03 01; 363(6430):993-998.
PMID:
30819965
; PMCID:
PMC6637967
.
Citations:
24
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Hu X, Zhang J, Wang J,
Fu J
, Li T, Zheng X, Wang B,
Gu S
, Jiang P, Fan J, Ying X, Zhang J,
Carroll MC
,
Wucherpfennig KW
,
Hacohen N
, Zhang F, Zhang P, Liu JS, Li B, Liu XS. Landscape of B cell immunity and related immune evasion in human cancers. Nat Genet. 2019 03; 51(3):560-567.
PMID:
30742113
; PMCID:
PMC6773274
.
Citations:
59
Fields:
Gen
Genetics
Translation:
Humans
Cells
Keskin DB
, Anandappa AJ, Sun J, Tirosh I, Mathewson ND, Li S,
Oliveira G
, Giobbie-Hurder A, Felt K, Gjini E, Shukla SA, Hu Z, Li L, Le PM, Allesøe RL, Richman AR, Kowalczyk MS, Abdelrahman S, Geduldig JE, Charbonneau S, Pelton K, Iorgulescu JB, Elagina L, Zhang W, Olive O, McCluskey C, Olsen LR, Stevens J,
Lane WJ
, Salazar AM, Daley H,
Wen PY
,
Chiocca EA
, Harden M, Lennon NJ, Gabriel S,
Getz G
,
Lander ES
, Regev A,
Ritz J
,
Neuberg D
,
Rodig SJ
,
Ligon KL
, Suvà ML,
Wucherpfennig KW
,
Hacohen N
,
Fritsch EF
, Livak KJ,
Ott PA
,
Wu CJ
,
Reardon DA
. Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial. Nature. 2019 01; 565(7738):234-239.
PMID:
30568305
.
Citations:
495
Fields:
Sci
Science
Translation:
Humans
Cells
CT
Clinical Trials
Formenti SC, Rudqvist NP, Golden E, Cooper B, Wennerberg E, Lhuillier C, Vanpouille-Box C, Friedman K, Ferrari de Andrade L,
Wucherpfennig KW
, Heguy A, Imai N, Gnjatic S, Emerson RO, Zhou XK, Zhang T, Chachoua A, Demaria S. Radiotherapy induces responses of lung cancer to CTLA-4 blockade. Nat Med. 2018 12; 24(12):1845-1851.
PMID:
30397353
; PMCID:
PMC6286242
.
Citations:
287
Fields:
Med
Medicine (General)
Mol
Molecular Biology
Translation:
Humans
Cells
CT
Clinical Trials
Jerby-Arnon L, Shah P, Cuoco MS, Rodman C, Su MJ, Melms JC, Leeson R, Kanodia A, Mei S, Lin JR, Wang S, Rabasha B,
Liu D
, Zhang G, Margolais C, Ashenberg O,
Ott PA
,
Buchbinder EI
,
Haq R
,
Hodi FS
,
Boland GM
, Sullivan RJ, Frederick DT, Miao B, Moll T,
Flaherty KT
, Herlyn M,
Jenkins RW
, Thummalapalli R, Kowalczyk MS, Cañadas I, Schilling B, Cartwright ANR, Luoma AM, Malu S, Hwu P, Bernatchez C, Forget MA,
Barbie DA
,
Shalek AK
, Tirosh I,
Sorger PK
,
Wucherpfennig K
,
Van Allen EM
, Schadendorf D,
Johnson BE
,
Rotem A
, Rozenblatt-Rosen O, Garraway LA,
Yoon CH
, Izar B, Regev A. A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade. Cell. 2018 11 01; 175(4):984-997.e24.
PMID:
30388455
; PMCID:
PMC6410377
.
Citations:
425
Fields:
Cel
Cell Biology
Translation:
Humans
Animals
Cells
Cremasco V, Astarita JL, Grauel AL, Keerthivasan S, MacIsaac K, Woodruff MC,
Wu M
, Spel L, Santoro S, Amoozgar Z, Laszewski T, Migoni SC, Knoblich K, Fletcher AL,
LaFleur M
,
Wucherpfennig KW
, Pure E, Dranoff G,
Carroll MC
, Turley SJ. FAP Delineates Heterogeneous and Functionally Divergent Stromal Cells in Immune-Excluded Breast Tumors. Cancer Immunol Res. 2018 12; 6(12):1472-1485.
PMID:
30266714
; PMCID:
PMC6597261
.
Citations:
77
Fields:
All
Allergy and Immunology
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Ito Y, Ashenberg O, Pyrdol J, Luoma AM, Rozenblatt-Rosen O, Hofree M, Christian E, Ferrari de Andrade L, Tay RE, Teyton L, Regev A,
Dougan SK
,
Wucherpfennig KW
. Rapid CLIP dissociation from MHC II promotes an unusual antigen presentation pathway in autoimmunity. J Exp Med. 2018 10 01; 215(10):2617-2635.
PMID:
30185635
; PMCID:
PMC6170167
.
Citations:
15
Fields:
All
Allergy and Immunology
Med
Medicine (General)
Translation:
Animals
Cells
Jiang P,
Gu S
, Pan D,
Fu J
, Sahu A, Hu X, Li Z, Traugh N,
Bu X
, Li B, Liu J,
Freeman GJ
,
Brown MA
,
Wucherpfennig KW
, Liu XS. Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response. Nat Med. 2018 10; 24(10):1550-1558.
PMID:
30127393
; PMCID:
PMC6487502
.
Citations:
1397
Fields:
Med
Medicine (General)
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Kim YC, Zhang AH, Yoon J, Culp WE, Lees JR,
Wucherpfennig KW
, Scott DW. Engineered MBP-specific human Tregs ameliorate MOG-induced EAE through IL-2-triggered inhibition of effector T cells. J Autoimmun. 2018 08; 92:77-86.
PMID:
29857928
; PMCID:
PMC6054915
.
Citations:
33
Fields:
All
Allergy and Immunology
Translation:
Humans
Animals
Cells
Clark LE, Mahmutovic S, Raymond DD, Dilanyan T, Koma T, Manning JT, Shankar S, Levis SC, Briggiler AM, Enria DA,
Wucherpfennig KW
, Paessler S,
Abraham J
. Vaccine-elicited receptor-binding site antibodies neutralize two New World hemorrhagic fever arenaviruses. Nat Commun. 2018 05 14; 9(1):1884.
PMID:
29760382
.
Citations:
25
Fields:
Bio
Biology
Sci
Science
Translation:
Humans
Cells
Filbin MG
, Tirosh I,
Hovestadt V
, Shaw ML, Escalante LE, Mathewson ND, Neftel C, Frank N, Pelton K, Hebert CM, Haberler C, Yizhak K, Gojo J, Egervari K,
Mount C
,
van Galen P
, Bonal DM,
Nguyen QD
, Beck A, Sinai C, Czech T, Dorfer C, Goumnerova L, Lavarino C, Carcaboso AM, Mora J, Mylvaganam R, Luo CC, Peyrl A, Popovic M, Azizi A,
Batchelor TT
,
Frosch MP
, Martinez-Lage M, Kieran MW,
Bandopadhayay P
,
Beroukhim R
, Fritsch G,
Getz G
, Rozenblatt-Rosen O,
Wucherpfennig KW
,
Louis DN
, Monje M, Slavc I,
Ligon KL
,
Golub TR
, Regev A,
Bernstein BE
, Suvà ML. Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq. Science. 2018 04 20; 360(6386):331-335.
PMID:
29674595
.
Citations:
218
Fields:
Sci
Science
Translation:
Humans
Cells
Ferrari de Andrade L, Tay RE, Pan D, Luoma AM, Ito Y, Badrinath S, Tsoucas D, Franz B, May KF, Harvey CJ, Kobold S, Pyrdol JW,
Yoon C
, Yuan GC,
Hodi FS
, Dranoff G,
Wucherpfennig KW
. Antibody-mediated inhibition of MICA and MICB shedding promotes NK cell-driven tumor immunity. Science. 2018 Mar 30; 359(6383):1537-1542.
PMID:
29599246
; PMCID:
PMC6626532
.
Citations:
170
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Ott PA
, Hu Z,
Keskin DB
, Shukla SA, Sun J, Bozym DJ, Zhang W, Luoma A, Giobbie-Hurder A, Peter L, Chen C, Olive O, Carter TA, Li S, Lieb DJ, Eisenhaure T, Gjini E, Stevens J,
Lane WJ
, Javeri I, Nellaiappan K, Salazar AM, Daley H,
Seaman M
,
Buchbinder EI
,
Yoon CH
, Harden M, Lennon N, Gabriel S,
Rodig SJ
,
Barouch DH
, Aster JC, Getz G,
Wucherpfennig K
,
Neuberg D
,
Ritz J
,
Lander ES
,
Fritsch EF
,
Hacohen N
,
Wu CJ
. Corrigendum: An immunogenic personal neoantigen vaccine for patients with melanoma. Nature. 2018 03 14; 555(7696):402.
PMID:
29542692
.
Citations:
9
Fields:
Sci
Science
Li AW, Sobral MC, Badrinath S, Choi Y, Graveline A, Stafford AG, Weaver JC, Dellacherie MO, Shih TY, Ali OA, Kim J,
Wucherpfennig KW
, Mooney DJ. A facile approach to enhance antigen response for personalized cancer vaccination. Nat Mater. 2018 06; 17(6):528-534.
PMID:
29507416
; PMCID:
PMC5970019
.
Citations:
101
Fields:
Che
Chemistry
Sci
Science
Translation:
Humans
Animals
Cells
PH
Public Health
Choi IK, Wang Z, Ke Q, Hong M, Qian Y, Zhao X, Liu Y, Kim HJ,
Ritz J
,
Cantor H
, Rajewsky K,
Wucherpfennig KW
,
Zhang B
. Signaling by the Epstein-Barr virus LMP1 protein induces potent cytotoxic CD4+ and CD8+ T cell responses. Proc Natl Acad Sci U S A. 2018 01 23; 115(4):E686-E695.
PMID:
29311309
; PMCID:
PMC5789919
.
Citations:
21
Fields:
Sci
Science
Translation:
Animals
Cells
Pan D,
Kobayashi A
, Jiang P, Ferrari de Andrade L, Tay RE, Luoma AM, Tsoucas D,
Qiu X
, Lim K, Rao P,
Long HW
, Yuan GC, Doench J, Brown M, Liu XS,
Wucherpfennig KW
. A major chromatin regulator determines resistance of tumor cells to T cell-mediated killing. Science. 2018 02 16; 359(6377):770-775.
PMID:
29301958
; PMCID:
PMC5953516
.
Citations:
320
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Schmid D, Park CG, Hartl CA, Subedi N, Cartwright AN, Puerto RB, Zheng Y, Maiarana J,
Freeman GJ
,
Wucherpfennig KW
, Irvine DJ, Goldberg MS. T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity. Nat Commun. 2017 11 23; 8(1):1747.
PMID:
29170511
.
Citations:
137
Fields:
Bio
Biology
Sci
Science
Translation:
Humans
Animals
Cells
Reardon DA
,
Wucherpfennig K
,
Chiocca EA
. Immunotherapy for glioblastoma: on the sidelines or in the game? Discov Med. 2017 11; 24(133):201-208.
PMID:
29278673
.
Citations:
25
Fields:
Med
Medicine (General)
Translation:
Humans
Moffett HF, Cartwright ANR, Kim HJ, Godec J, Pyrdol J, Äijö T, Martinez GJ, Rao A, Lu J,
Golub TR
,
Cantor H
,
Sharpe AH
,
Novina CD
,
Wucherpfennig KW
. Erratum: The microRNA miR-31 inhibits CD8+ T cell function in chronic viral infection. Nat Immunol. 2017 09 19; 18(10):1173.
PMID:
28926530
.
Citations:
1
Fields:
All
Allergy and Immunology
Reardon DA
,
Wen PY
,
Wucherpfennig KW
, Sampson JH. Immunomodulation for glioblastoma. Curr Opin Neurol. 2017 06; 30(3):361-369.
PMID:
28368867
.
Citations:
10
Fields:
Neu
Neurology
Translation:
Humans
Moffett HF, Cartwright ANR, Kim HJ, Godec J, Pyrdol J, Äijö T, Martinez GJ, Rao A, Lu J,
Golub TR
,
Cantor H
,
Sharpe AH
,
Novina CD
,
Wucherpfennig KW
. The microRNA miR-31 inhibits CD8+ T cell function in chronic viral infection. Nat Immunol. 2017 Jul; 18(7):791-799.
PMID:
28530712
; PMCID:
PMC5753758
.
Citations:
32
Fields:
All
Allergy and Immunology
Translation:
Animals
Cells
Van Elssen CHMJ,
Rashidian M
, Vrbanac V,
Wucherpfennig KW
, Habre ZE, Sticht J, Freund C, Jacobsen JT, Cragnolini J, Ingram J, Plaisier L, Spierings E, Tager AM, Ploegh HL. Noninvasive Imaging of Human Immune Responses in a Human Xenograft Model of Graft-Versus-Host Disease. J Nucl Med. 2017 06; 58(6):1003-1008.
PMID:
28209904
; PMCID:
PMC5450362
.
Citations:
30
Fields:
Nuc
Nuclear Medicine
Translation:
Humans
Animals
Cells
Verbeke CS, Gordo S, Schubert DA, Lewin SA, Desai RM, Dobbins J,
Wucherpfennig KW
, Mooney DJ. Multicomponent Injectable Hydrogels for Antigen-Specific Tolerogenic Immune Modulation. Adv Healthc Mater. 2017 Mar; 6(6).
PMID:
28116870
.
Citations:
31
Fields:
Bio
Biomedical Engineering
Tec
Technology
Translation:
Animals
Cells
Gagnon E, Connolly A, Dobbins J,
Wucherpfennig KW
. Studying Dynamic Plasma Membrane Binding of TCR-CD3 Chains During Immunological Synapse Formation Using Donor-Quenching FRET and FLIM-FRET. Methods Mol Biol. 2017; 1584:259-289.
PMID:
28255707
.
Citations:
1
Fields:
Mol
Molecular Biology
Translation:
Humans
Cells
Awad MM
, Jones RE, Liu H,
Lizotte PH
,
Ivanova EV
, Kulkarni M, Herter-Sprie GS, Liao X, Santos AA, Bittinger MA, Keogh L, Koyama S, Almonte C, English JM, Barlow J,
Richards WG
,
Barbie DA
, Bass AJ,
Rodig SJ
,
Hodi FS
,
Wucherpfennig KW
, Jänne PA,
Sholl LM
, Hammerman PS, Wong KK,
Bueno R
. Cytotoxic T Cells in PD-L1-Positive Malignant Pleural Mesotheliomas Are Counterbalanced by Distinct Immunosuppressive Factors. Cancer Immunol Res. 2016 12; 4(12):1038-1048.
PMID:
27856426
.
Citations:
34
Fields:
All
Allergy and Immunology
Neo
Neoplasms
Translation:
Humans
Cells
Dobbins J, Gagnon E, Godec J, Pyrdol J, Vignali DA,
Sharpe AH
,
Wucherpfennig KW
. Binding of the cytoplasmic domain of CD28 to the plasma membrane inhibits Lck recruitment and signaling. Sci Signal. 2016 07 26; 9(438):ra75.
PMID:
27460989
; PMCID:
PMC5929992
.
Citations:
26
Fields:
Cel
Cell Biology
Phy
Physiology
Sci
Science
Translation:
Humans
Animals
Cells
Wucherpfennig KW
, Cartwright AN. Genetic screens to study the immune system in cancer. Curr Opin Immunol. 2016 08; 41:55-61.
PMID:
27309352
; PMCID:
PMC4992665
.
Citations:
8
Fields:
All
Allergy and Immunology
Translation:
Humans
Animals
Fernandez-Carbonell C, Vargas-Lowy D, Musallam A,
Healy B
, McLaughlin K,
Wucherpfennig KW
,
Chitnis T
. Clinical and MRI phenotype of children with MOG antibodies. Mult Scler. 2016 Feb; 22(2):174-84.
PMID:
26041801
; PMCID:
PMC4669239
.
Citations:
45
Fields:
Neu
Neurology
Translation:
Humans
Sollid LM, Pos W,
Wucherpfennig KW
. Molecular mechanisms for contribution of MHC molecules to autoimmune diseases. Curr Opin Immunol. 2014 Dec; 31:24-30.
PMID:
25216261
.
Citations:
30
Fields:
All
Allergy and Immunology
Translation:
Humans
Animals
Reardon DA
,
Freeman G
, Wu C,
Chiocca EA
,
Wucherpfennig KW
,
Wen PY
,
Fritsch EF
,
Curry WT
, Sampson JH, Dranoff G. Immunotherapy advances for glioblastoma. Neuro Oncol. 2014 Nov; 16(11):1441-58.
PMID:
25190673
.
Citations:
96
Fields:
Neo
Neoplasms
Neu
Neurology
Translation:
Humans
Animals
Cremasco V, Woodruff MC, Onder L, Cupovic J,
Nieves-Bonilla JM
, Schildberg FA, Chang J, Cremasco F, Harvey CJ,
Wucherpfennig K
, Ludewig B,
Carroll MC
, Turley SJ. B cell homeostasis and follicle confines are governed by fibroblastic reticular cells. Nat Immunol. 2014 Oct; 15(10):973-81.
PMID: