Harvard Catalyst Profiles

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Kai Wucherpfennig, Ph.D., M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01CA251599 (WUCHERPFENNIG, KAI W) Aug 1, 2020 - Apr 30, 2025
    NIH
    Targeting of a Major Immune Evasion Pathway in Triple-negative Breast Cancer
    Role: Principal Investigator
  2. R01CA234018 (WUCHERPFENNIG, KAI W) May 15, 2019 - Apr 30, 2023
    NIH
    Regulators of Cancer Immunotherapy Response
    Role: Co-Principal Investigator
  3. R01CA238039 (WUCHERPFENNIG, KAI W) Mar 1, 2019 - Feb 29, 2024
    NIH
    Therapeutic Targeting of Immune Evasion from the MICA - NKG2D Pathway
    Role: Principal Investigator
  4. T32CA207021 (WUCHERPFENNIG, KAI W) Jul 13, 2016 - Jun 30, 2021
    NIH
    Cancer Immunology Training Grant
    Role: Principal Investigator
  5. R56AI104730 (WUCHERPFENNIG, KAI W) Aug 1, 2014 - Jul 31, 2017
    NIH
    Molecular mechanisms of HLA-DM mediated peptide exchange
    Role: Co-Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Mathewson ND, Ashenberg O, Tirosh I, Gritsch S, Perez EM, Marx S, Jerby-Arnon L, Chanoch-Myers R, Hara T, Richman AR, Ito Y, Pyrdol J, Friedrich M, Schumann K, Poitras MJ, Gokhale PC, Gonzalez Castro LN, Shore ME, Hebert CM, Shaw B, Cahill HL, Drummond M, Zhang W, Olawoyin O, Wakimoto H, Rozenblatt-Rosen O, Brastianos PK, Liu XS, Jones PS, Cahill DP, Frosch MP, Louis DN, Freeman GJ, Ligon KL, Marson A, Chiocca EA, Reardon DA, Regev A, Suvà ML, Wucherpfennig KW. Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis. Cell. 2021 Feb 10. PMID: 33592174.
    Citations:    Fields:    
  2. Cartwright ANR, Suo S, Badrinath S, Kumar S, Melms J, Luoma A, Bagati A, Saadatpour A, Izar B, Yuan GC, Wucherpfennig KW. Immunosuppressive Myeloid Cells Induce Nitric Oxide-Dependent DNA Damage and p53 Pathway Activation in CD8+ T Cells. Cancer Immunol Res. 2021 Jan 29. PMID: 33514509.
    Citations:    Fields:    
  3. Jerby-Arnon L, Neftel C, Shore ME, Weisman HR, Mathewson ND, McBride MJ, Haas B, Izar B, Volorio A, Boulay G, Cironi L, Richman AR, Broye LC, Gurski JM, Luo CC, Mylvaganam R, Nguyen L, Mei S, Melms JC, Georgescu C, Cohen O, Buendia-Buendia JE, Segerstolpe A, Sud M, Cuoco MS, Labes D, Gritsch S, Zollinger DR, Ortogero N, Beechem JM, Petur Nielsen G, Chebib I, Nguyen-Ngoc T, Montemurro M, Cote GM, Choy E, Letovanec I, Cherix S, Wagle N, Sorger PK, Haynes AB, Mullen JT, Stamenkovic I, Rivera MN, Kadoch C, Wucherpfennig KW, Rozenblatt-Rosen O, Suvà ML, Riggi N, Regev A. Opposing immune and genetic mechanisms shape oncogenic programs in synovial sarcoma. Nat Med. 2021 02; 27(2):289-300. PMID: 33495604.
    Citations:    Fields:    
  4. Hu Z, Leet DE, Allesøe RL, Oliveira G, Li S, Luoma AM, Liu J, Forman J, Huang T, Iorgulescu JB, Holden R, Sarkizova S, Gohil SH, Redd RA, Sun J, Elagina L, Giobbie-Hurder A, Zhang W, Peter L, Ciantra Z, Rodig S, Olive O, Shetty K, Pyrdol J, Uduman M, Lee PC, Bachireddy P, Buchbinder EI, Yoon CH, Neuberg D, Pentelute BL, Hacohen N, Livak KJ, Shukla SA, Olsen LR, Barouch DH, Wucherpfennig KW, Fritsch EF, Keskin DB, Wu CJ, Ott PA. Personal neoantigen vaccines induce persistent memory T cell responses and epitope spreading in patients with melanoma. Nat Med. 2021 Jan 21. PMID: 33479501.
    Citations:    Fields:    
  5. Bagati A, Kumar S, Jiang P, Pyrdol J, Zou AE, Godicelj A, Mathewson ND, Cartwright ANR, Cejas P, Brown M, Giobbie-Hurder A, Dillon D, Agudo J, Mittendorf EA, Liu XS, Wucherpfennig KW. Integrin avß6-TGFß-SOX4 Pathway Drives Immune Evasion in Triple-Negative Breast Cancer. Cancer Cell. 2021 Jan 11; 39(1):54-67.e9. PMID: 33385331.
    Citations:    Fields:    
  6. Choi IK, Wang Z, Ke Q, Hong M, Paul DW, Fernandes SM, Hu Z, Stevens J, Guleria I, Kim HJ, Cantor H, Wucherpfennig KW, Brown JR, Ritz J, Zhang B. Mechanism of EBV inducing anti-tumour immunity and its therapeutic use. Nature. 2021 Feb; 590(7844):157-162. PMID: 33361812.
    Citations: 1     Fields:    
  7. Schoenfeld JD, Hanna GJ, Jo VY, Rawal B, Chen YH, Catalano PS, Lako A, Ciantra Z, Weirather JL, Criscitiello S, Luoma A, Chau N, Lorch J, Kass JI, Annino D, Goguen L, Desai A, Ross B, Shah HJ, Jacene HA, Margalit DN, Tishler RB, Wucherpfennig KW, Rodig SJ, Uppaluri R, Haddad RI. Neoadjuvant Nivolumab or Nivolumab Plus Ipilimumab in Untreated Oral Cavity Squamous Cell Carcinoma: A Phase 2 Open-Label Randomized Clinical Trial. JAMA Oncol. 2020 10 01; 6(10):1563-1570. PMID: 32852531.
    Citations: 1     Fields:    Translation:HumansCTClinical Trials
  8. Shi S, Gu S, Han T, Zhang W, Huang L, Li Z, Pan D, Fu J, Ge J, Brown M, Zhang P, Jiang P, Wucherpfennig KW, Liu XS. Inhibition of MAN2A1 Enhances the Immune Response to Anti-PD-L1 in Human Tumors. Clin Cancer Res. 2020 Nov 15; 26(22):5990-6002. PMID: 32723834.
    Citations:    Fields:    
  9. Gojo J, Englinger B, Jiang L, Hübner JM, Shaw ML, Hack OA, Madlener S, Kirchhofer D, Liu I, Pyrdol J, Hovestadt V, Mazzola E, Mathewson ND, Trissal M, Lötsch D, Dorfer C, Haberler C, Halfmann A, Mayr L, Peyrl A, Geyeregger R, Schwalm B, Mauermann M, Pajtler KW, Milde T, Shore ME, Geduldig JE, Pelton K, Czech T, Ashenberg O, Wucherpfennig KW, Rozenblatt-Rosen O, Alexandrescu S, Ligon KL, Pfister SM, Regev A, Slavc I, Berger W, Suvà ML, Kool M, Filbin MG. Single-Cell RNA-Seq Reveals Cellular Hierarchies and Impaired Developmental Trajectories in Pediatric Ependymoma. Cancer Cell. 2020 07 13; 38(1):44-59.e9. PMID: 32663469.
    Citations:    Fields:    
  10. Tay RE, Olawoyin O, Cejas P, Xie Y, Meyer CA, Ito Y, Weng QY, Fisher DE, Long HW, Brown M, Kim HJ, Wucherpfennig KW. Hdac3 is an epigenetic inhibitor of the cytotoxicity program in CD8 T cells. J Exp Med. 2020 07 06; 217(7). PMID: 32374402.
    Citations: 1     Fields:    
  11. Tay RE, Olawoyin O, Cejas P, Xie Y, Meyer CA, Ito Y, Weng QY, Fisher DE, Long HW, Brown M, Kim HJ, Wucherpfennig KW. Correction: Hdac3 is an epigenetic inhibitor of the cytotoxicity program in CD8 T cells. J Exp Med. 2020 07 06; 217(7). PMID: 32441763.
    Citations: 1     Fields:    
  12. Luoma AM, Suo S, Williams HL, Sharova T, Sullivan K, Manos M, Bowling P, Hodi FS, Rahma O, Sullivan RJ, Boland GM, Nowak JA, Dougan SK, Dougan M, Yuan GC, Wucherpfennig KW. Molecular Pathways of Colon Inflammation Induced by Cancer Immunotherapy. Cell. 2020 Aug 06; 182(3):655-671.e22. PMID: 32603654.
    Citations: 4     Fields:    
  13. Wang H, Sobral MC, Zhang DKY, Cartwright AN, Li AW, Dellacherie MO, Tringides CM, Koshy ST, Wucherpfennig KW, Mooney DJ. Metabolic labeling and targeted modulation of dendritic cells. Nat Mater. 2020 Nov; 19(11):1244-1252. PMID: 32424368.
    Citations:    Fields:    
  14. Shu S, Wu HJ, Ge JY, Zeid R, Harris IS, Jovanovic B, Murphy K, Wang B, Qiu X, Endress JE, Reyes J, Lim K, Font-Tello A, Syamala S, Xiao T, Reddy Chilamakuri CS, Papachristou EK, D'Santos C, Anand J, Hinohara K, Li W, McDonald TO, Luoma A, Modiste RJ, Nguyen QD, Michel B, Cejas P, Kadoch C, Jaffe JD, Wucherpfennig KW, Qi J, Liu XS, Long H, Brown M, Carroll JS, Brugge JS, Bradner J, Michor F, Polyak K. Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer. Mol Cell. 2020 06 18; 78(6):1096-1113.e8. PMID: 32416067.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  15. Ge JY, Shu S, Kwon M, Jovanovic B, Murphy K, Gulvady A, Fassl A, Trinh A, Kuang Y, Heavey GA, Luoma A, Paweletz C, Thorner AR, Wucherpfennig KW, Qi J, Brown M, Sicinski P, McDonald TO, Pellman D, Michor F, Polyak K. Acquired resistance to combined BET and CDK4/6 inhibition in triple-negative breast cancer. Nat Commun. 2020 05 11; 11(1):2350. PMID: 32393766.
    Citations: 1     Fields:    Translation:AnimalsCells
  16. Ferrari de Andrade L, Kumar S, Luoma AM, Ito Y, Alves da Silva PH, Pan D, Pyrdol JW, Yoon CH, Wucherpfennig KW. Inhibition of MICA and MICB Shedding Elicits NK-Cell-Mediated Immunity against Tumors Resistant to Cytotoxic T Cells. Cancer Immunol Res. 2020 06; 8(6):769-780. PMID: 32209637.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  17. Murata K, Jadhav U, Madha S, van Es J, Dean J, Cavazza A, Wucherpfennig K, Michor F, Clevers H, Shivdasani RA. Ascl2-Dependent Cell Dedifferentiation Drives Regeneration of Ablated Intestinal Stem Cells. Cell Stem Cell. 2020 03 05; 26(3):377-390.e6. PMID: 32084390.
    Citations: 20     Fields:    
  18. McCarthy N, Manieri E, Storm EE, Saadatpour A, Luoma AM, Kapoor VN, Madha S, Gaynor LT, Cox C, Keerthivasan S, Wucherpfennig K, Yuan GC, de Sauvage FJ, Turley SJ, Shivdasani RA. Distinct Mesenchymal Cell Populations Generate the Essential Intestinal BMP Signaling Gradient. Cell Stem Cell. 2020 03 05; 26(3):391-402.e5. PMID: 32084389.
    Citations: 11     Fields:    
  19. Jadhav U, Manieri E, Nalapareddy K, Madha S, Chakrabarti S, Wucherpfennig K, Barefoot M, Shivdasani RA. Replicational Dilution of H3K27me3 in Mammalian Cells and the Role of Poised Promoters. Mol Cell. 2020 04 02; 78(1):141-151.e5. PMID: 32027840.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  20. Melms JC, Vallabhaneni S, Mills CE, Yapp C, Chen JY, Morelli E, Waszyk P, Kumar S, Deming D, Moret N, Rodriguez S, Subramanian K, Rogava M, Cartwright ANR, Luoma A, Mei S, Brinker TJ, Miller DM, Spektor A, Schadendorf D, Riggi N, Wucherpfennig KW, Sorger PK, Izar B. Inhibition of Haspin Kinase Promotes Cell-Intrinsic and Extrinsic Antitumor Activity. Cancer Res. 2020 02 15; 80(4):798-810. PMID: 31882401.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  21. de Andrade LF, Lu Y, Luoma A, Ito Y, Pan D, Pyrdol JW, Yoon CH, Yuan GC, Wucherpfennig KW. Discovery of specialized NK cell populations infiltrating human melanoma metastases. JCI Insight. 2019 12 05; 4(23). PMID: 31801909.
    Citations: 8     Fields:    Translation:HumansCells
  22. Alspach E, Lussier DM, Miceli AP, Kizhvatov I, DuPage M, Luoma AM, Meng W, Lichti CF, Esaulova E, Vomund AN, Runci D, Ward JP, Gubin MM, Medrano RFV, Arthur CD, White JM, Sheehan KCF, Chen A, Wucherpfennig KW, Jacks T, Unanue ER, Artyomov MN, Schreiber RD. MHC-II neoantigens shape tumour immunity and response to immunotherapy. Nature. 2019 10; 574(7780):696-701. PMID: 31645760.
    Citations: 80     Fields:    Translation:HumansAnimalsCells
  23. Kula T, Dezfulian MH, Wang CI, Abdelfattah NS, Hartman ZC, Wucherpfennig KW, Lyerly HK, Elledge SJ. T-Scan: A Genome-wide Method for the Systematic Discovery of T Cell Epitopes. Cell. 2019 08 08; 178(4):1016-1028.e13. PMID: 31398327.
    Citations: 22     Fields:    Translation:HumansCells
  24. Janiszewska M, Tabassum DP, Castaño Z, Cristea S, Yamamoto KN, Kingston NL, Murphy KC, Shu S, Harper NW, Del Alcazar CG, Aleckovic M, Ekram MB, Cohen O, Kwak M, Qin Y, Laszewski T, Luoma A, Marusyk A, Wucherpfennig KW, Wagle N, Fan R, Michor F, McAllister SS, Polyak K. Subclonal cooperation drives metastasis by modulating local and systemic immune microenvironments. Nat Cell Biol. 2019 07; 21(7):879-888. PMID: 31263265.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  25. Hu X, Zhang J, Wang J, Fu J, Li T, Zheng X, Wang B, Gu S, Jiang P, Fan J, Ying X, Zhang J, Carroll MC, Wucherpfennig KW, Hacohen N, Zhang F, Zhang P, Liu JS, Li B, Liu XS. Publisher Correction: Landscape of B cell immunity and related immune evasion in human cancers. Nat Genet. 2019 Jun; 51(6):1068. PMID: 31101897.
    Citations:    Fields:    
  26. Chan LL, Wucherpfennig KW, de Andrade LF. Visualization and quantification of NK cell-mediated cytotoxicity over extended time periods by image cytometry. J Immunol Methods. 2019 06; 469:47-51. PMID: 30951701.
    Citations: 4     Fields:    Translation:HumansCells
  27. Grootjans J, Krupka N, Hosomi S, Matute JD, Hanley T, Saveljeva S, Gensollen T, Heijmans J, Li H, Limenitakis JP, Ganal-Vonarburg SC, Suo S, Luoma AM, Shimodaira Y, Duan J, Shih DQ, Conner ME, Glickman JN, Fuhler GM, Palm NW, de Zoete MR, van der Woude CJ, Yuan GC, Wucherpfennig KW, Targan SR, Rosenstiel P, Flavell RA, McCoy KD, Macpherson AJ, Kaser A, Blumberg RS. Epithelial endoplasmic reticulum stress orchestrates a protective IgA response. Science. 2019 03 01; 363(6430):993-998. PMID: 30819965.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  28. Hu X, Zhang J, Wang J, Fu J, Li T, Zheng X, Wang B, Gu S, Jiang P, Fan J, Ying X, Zhang J, Carroll MC, Wucherpfennig KW, Hacohen N, Zhang F, Zhang P, Liu JS, Li B, Liu XS. Landscape of B cell immunity and related immune evasion in human cancers. Nat Genet. 2019 03; 51(3):560-567. PMID: 30742113.
    Citations: 21     Fields:    Translation:HumansCells
  29. Keskin DB, Anandappa AJ, Sun J, Tirosh I, Mathewson ND, Li S, Oliveira G, Giobbie-Hurder A, Felt K, Gjini E, Shukla SA, Hu Z, Li L, Le PM, Allesøe RL, Richman AR, Kowalczyk MS, Abdelrahman S, Geduldig JE, Charbonneau S, Pelton K, Iorgulescu JB, Elagina L, Zhang W, Olive O, McCluskey C, Olsen LR, Stevens J, Lane WJ, Salazar AM, Daley H, Wen PY, Chiocca EA, Harden M, Lennon NJ, Gabriel S, Getz G, Lander ES, Regev A, Ritz J, Neuberg D, Rodig SJ, Ligon KL, Suvà ML, Wucherpfennig KW, Hacohen N, Fritsch EF, Livak KJ, Ott PA, Wu CJ, Reardon DA. Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial. Nature. 2019 01; 565(7738):234-239. PMID: 30568305.
    Citations: 165     Fields:    Translation:HumansCellsCTClinical Trials
  30. Formenti SC, Rudqvist NP, Golden E, Cooper B, Wennerberg E, Lhuillier C, Vanpouille-Box C, Friedman K, Ferrari de Andrade L, Wucherpfennig KW, Heguy A, Imai N, Gnjatic S, Emerson RO, Zhou XK, Zhang T, Chachoua A, Demaria S. Radiotherapy induces responses of lung cancer to CTLA-4 blockade. Nat Med. 2018 12; 24(12):1845-1851. PMID: 30397353.
    Citations: 99     Fields:    Translation:HumansCellsCTClinical Trials
  31. Jerby-Arnon L, Shah P, Cuoco MS, Rodman C, Su MJ, Melms JC, Leeson R, Kanodia A, Mei S, Lin JR, Wang S, Rabasha B, Liu D, Zhang G, Margolais C, Ashenberg O, Ott PA, Buchbinder EI, Haq R, Hodi FS, Boland GM, Sullivan RJ, Frederick DT, Miao B, Moll T, Flaherty KT, Herlyn M, Jenkins RW, Thummalapalli R, Kowalczyk MS, Cañadas I, Schilling B, Cartwright ANR, Luoma AM, Malu S, Hwu P, Bernatchez C, Forget MA, Barbie DA, Shalek AK, Tirosh I, Sorger PK, Wucherpfennig K, Van Allen EM, Schadendorf D, Johnson BE, Rotem A, Rozenblatt-Rosen O, Garraway LA, Yoon CH, Izar B, Regev A. A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade. Cell. 2018 11 01; 175(4):984-997.e24. PMID: 30388455.
    Citations: 131     Fields:    Translation:HumansAnimalsCells
  32. Cremasco V, Astarita JL, Grauel AL, Keerthivasan S, MacIsaac K, Woodruff MC, Wu M, Spel L, Santoro S, Amoozgar Z, Laszewski T, Migoni SC, Knoblich K, Fletcher AL, LaFleur M, Wucherpfennig KW, Pure E, Dranoff G, Carroll MC, Turley SJ. FAP Delineates Heterogeneous and Functionally Divergent Stromal Cells in Immune-Excluded Breast Tumors. Cancer Immunol Res. 2018 12; 6(12):1472-1485. PMID: 30266714.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  33. Ito Y, Ashenberg O, Pyrdol J, Luoma AM, Rozenblatt-Rosen O, Hofree M, Christian E, Ferrari de Andrade L, Tay RE, Teyton L, Regev A, Dougan SK, Wucherpfennig KW. Rapid CLIP dissociation from MHC II promotes an unusual antigen presentation pathway in autoimmunity. J Exp Med. 2018 10 01; 215(10):2617-2635. PMID: 30185635.
    Citations: 6     Fields:    Translation:AnimalsCells
  34. Jiang P, Gu S, Pan D, Fu J, Sahu A, Hu X, Li Z, Traugh N, Bu X, Li B, Liu J, Freeman GJ, Brown MA, Wucherpfennig KW, Liu XS. Signatures of T cell dysfunction and exclusion predict cancer immunotherapy response. Nat Med. 2018 10; 24(10):1550-1558. PMID: 30127393.
    Citations: 170     Fields:    Translation:HumansAnimalsCells
  35. Kim YC, Zhang AH, Yoon J, Culp WE, Lees JR, Wucherpfennig KW, Scott DW. Engineered MBP-specific human Tregs ameliorate MOG-induced EAE through IL-2-triggered inhibition of effector T cells. J Autoimmun. 2018 08; 92:77-86. PMID: 29857928.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  36. Clark LE, Mahmutovic S, Raymond DD, Dilanyan T, Koma T, Manning JT, Shankar S, Levis SC, Briggiler AM, Enria DA, Wucherpfennig KW, Paessler S, Abraham J. Vaccine-elicited receptor-binding site antibodies neutralize two New World hemorrhagic fever arenaviruses. Nat Commun. 2018 05 14; 9(1):1884. PMID: 29760382.
    Citations: 9     Fields:    Translation:HumansCells
  37. Filbin MG, Tirosh I, Hovestadt V, Shaw ML, Escalante LE, Mathewson ND, Neftel C, Frank N, Pelton K, Hebert CM, Haberler C, Yizhak K, Gojo J, Egervari K, Mount C, van Galen P, Bonal DM, Nguyen QD, Beck A, Sinai C, Czech T, Dorfer C, Goumnerova L, Lavarino C, Carcaboso AM, Mora J, Mylvaganam R, Luo CC, Peyrl A, Popovic M, Azizi A, Batchelor TT, Frosch MP, Martinez-Lage M, Kieran MW, Bandopadhayay P, Beroukhim R, Fritsch G, Getz G, Rozenblatt-Rosen O, Wucherpfennig KW, Louis DN, Monje M, Slavc I, Ligon KL, Golub TR, Regev A, Bernstein BE, Suvà ML. Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq. Science. 2018 04 20; 360(6386):331-335. PMID: 29674595.
    Citations: 78     Fields:    Translation:HumansCells
  38. Ferrari de Andrade L, Tay RE, Pan D, Luoma AM, Ito Y, Badrinath S, Tsoucas D, Franz B, May KF, Harvey CJ, Kobold S, Pyrdol JW, Yoon C, Yuan GC, Hodi FS, Dranoff G, Wucherpfennig KW. Antibody-mediated inhibition of MICA and MICB shedding promotes NK cell-driven tumor immunity. Science. 2018 Mar 30; 359(6383):1537-1542. PMID: 29599246.
    Citations: 80     Fields:    Translation:HumansAnimalsCells
  39. Ott PA, Hu Z, Keskin DB, Shukla SA, Sun J, Bozym DJ, Zhang W, Luoma A, Giobbie-Hurder A, Peter L, Chen C, Olive O, Carter TA, Li S, Lieb DJ, Eisenhaure T, Gjini E, Stevens J, Lane WJ, Javeri I, Nellaiappan K, Salazar AM, Daley H, Seaman M, Buchbinder EI, Yoon CH, Harden M, Lennon N, Gabriel S, Rodig SJ, Barouch DH, Aster JC, Getz G, Wucherpfennig K, Neuberg D, Ritz J, Lander ES, Fritsch EF, Hacohen N, Wu CJ. Corrigendum: An immunogenic personal neoantigen vaccine for patients with melanoma. Nature. 2018 03 14; 555(7696):402. PMID: 29542692.
    Citations: 5     Fields:    
  40. Li AW, Sobral MC, Badrinath S, Choi Y, Graveline A, Stafford AG, Weaver JC, Dellacherie MO, Shih TY, Ali OA, Kim J, Wucherpfennig KW, Mooney DJ. A facile approach to enhance antigen response for personalized cancer vaccination. Nat Mater. 2018 06; 17(6):528-534. PMID: 29507416.
    Citations: 38     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  41. Choi IK, Wang Z, Ke Q, Hong M, Qian Y, Zhao X, Liu Y, Kim HJ, Ritz J, Cantor H, Rajewsky K, Wucherpfennig KW, Zhang B. Signaling by the Epstein-Barr virus LMP1 protein induces potent cytotoxic CD4+ and CD8+ T cell responses. Proc Natl Acad Sci U S A. 2018 01 23; 115(4):E686-E695. PMID: 29311309.
    Citations: 4     Fields:    Translation:AnimalsCells
  42. Pan D, Kobayashi A, Jiang P, Ferrari de Andrade L, Tay RE, Luoma AM, Tsoucas D, Qiu X, Lim K, Rao P, Long HW, Yuan GC, Doench J, Brown M, Liu XS, Wucherpfennig KW. A major chromatin regulator determines resistance of tumor cells to T cell-mediated killing. Science. 2018 02 16; 359(6377):770-775. PMID: 29301958.
    Citations: 141     Fields:    Translation:HumansAnimalsCells
  43. Schmid D, Park CG, Hartl CA, Subedi N, Cartwright AN, Puerto RB, Zheng Y, Maiarana J, Freeman GJ, Wucherpfennig KW, Irvine DJ, Goldberg MS. T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity. Nat Commun. 2017 11 23; 8(1):1747. PMID: 29170511.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  44. Reardon DA, Wucherpfennig K, Chiocca EA. Immunotherapy for glioblastoma: on the sidelines or in the game? Discov Med. 2017 11; 24(133):201-208. PMID: 29278673.
    Citations: 12     Fields:    Translation:Humans
  45. Moffett HF, Cartwright ANR, Kim HJ, Godec J, Pyrdol J, Äijö T, Martinez GJ, Rao A, Lu J, Golub TR, Cantor H, Sharpe AH, Novina CD, Wucherpfennig KW. Erratum: The microRNA miR-31 inhibits CD8+ T cell function in chronic viral infection. Nat Immunol. 2017 09 19; 18(10):1173. PMID: 28926530.
    Citations: 1     Fields:    
  46. Reardon DA, Wen PY, Wucherpfennig KW, Sampson JH. Immunomodulation for glioblastoma. Curr Opin Neurol. 2017 06; 30(3):361-369. PMID: 28368867.
    Citations: 8     Fields:    Translation:Humans
  47. Moffett HF, Cartwright ANR, Kim HJ, Godec J, Pyrdol J, Äijö T, Martinez GJ, Rao A, Lu J, Golub TR, Cantor H, Sharpe AH, Novina CD, Wucherpfennig KW. The microRNA miR-31 inhibits CD8+ T cell function in chronic viral infection. Nat Immunol. 2017 Jul; 18(7):791-799. PMID: 28530712.
    Citations: 14     Fields:    Translation:AnimalsCells
  48. Van Elssen CHMJ, Rashidian M, Vrbanac V, Wucherpfennig KW, Habre ZE, Sticht J, Freund C, Jacobsen JT, Cragnolini J, Ingram J, Plaisier L, Spierings E, Tager AM, Ploegh HL. Noninvasive Imaging of Human Immune Responses in a Human Xenograft Model of Graft-Versus-Host Disease. J Nucl Med. 2017 06; 58(6):1003-1008. PMID: 28209904.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  49. Verbeke CS, Gordo S, Schubert DA, Lewin SA, Desai RM, Dobbins J, Wucherpfennig KW, Mooney DJ. Multicomponent Injectable Hydrogels for Antigen-Specific Tolerogenic Immune Modulation. Adv Healthc Mater. 2017 Mar; 6(6). PMID: 28116870.
    Citations: 13     Fields:    Translation:AnimalsCells
  50. Gagnon E, Connolly A, Dobbins J, Wucherpfennig KW. Studying Dynamic Plasma Membrane Binding of TCR-CD3 Chains During Immunological Synapse Formation Using Donor-Quenching FRET and FLIM-FRET. Methods Mol Biol. 2017; 1584:259-289. PMID: 28255707.
    Citations: 1     Fields:    Translation:HumansCells
  51. Awad MM, Jones RE, Liu H, Lizotte PH, Ivanova EV, Kulkarni M, Herter-Sprie GS, Liao X, Santos AA, Bittinger MA, Keogh L, Koyama S, Almonte C, English JM, Barlow J, Richards WG, Barbie DA, Bass AJ, Rodig SJ, Hodi FS, Wucherpfennig KW, Jänne PA, Sholl LM, Hammerman PS, Wong KK, Bueno R. Cytotoxic T Cells in PD-L1-Positive Malignant Pleural Mesotheliomas Are Counterbalanced by Distinct Immunosuppressive Factors. Cancer Immunol Res. 2016 12; 4(12):1038-1048. PMID: 27856426.
    Citations: 17     Fields:    Translation:HumansCells
  52. Dobbins J, Gagnon E, Godec J, Pyrdol J, Vignali DA, Sharpe AH, Wucherpfennig KW. Binding of the cytoplasmic domain of CD28 to the plasma membrane inhibits Lck recruitment and signaling. Sci Signal. 2016 07 26; 9(438):ra75. PMID: 27460989.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  53. Wucherpfennig KW, Cartwright AN. Genetic screens to study the immune system in cancer. Curr Opin Immunol. 2016 08; 41:55-61. PMID: 27309352.
    Citations: 6     Fields:    Translation:HumansAnimals
  54. Fernandez-Carbonell C, Vargas-Lowy D, Musallam A, Healy B, McLaughlin K, Wucherpfennig KW, Chitnis T. Clinical and MRI phenotype of children with MOG antibodies. Mult Scler. 2016 Feb; 22(2):174-84. PMID: 26041801.
    Citations: 29     Fields:    Translation:Humans
  55. Sollid LM, Pos W, Wucherpfennig KW. Molecular mechanisms for contribution of MHC molecules to autoimmune diseases. Curr Opin Immunol. 2014 Dec; 31:24-30. PMID: 25216261.
    Citations: 20     Fields:    Translation:HumansAnimals
  56. Reardon DA, Freeman G, Wu C, Chiocca EA, Wucherpfennig KW, Wen PY, Fritsch EF, Curry WT, Sampson JH, Dranoff G. Immunotherapy advances for glioblastoma. Neuro Oncol. 2014 Nov; 16(11):1441-58. PMID: 25190673.
    Citations: 68     Fields:    Translation:HumansAnimals
  57. Cremasco V, Woodruff MC, Onder L, Cupovic J, Nieves-Bonilla JM, Schildberg FA, Chang J, Cremasco F, Harvey CJ, Wucherpfennig K, Ludewig B, Carroll MC, Turley SJ. B cell homeostasis and follicle confines are governed by fibroblastic reticular cells. Nat Immunol. 2014 Oct; 15(10):973-81. PMID: 25151489.
    Citations: 81     Fields:    Translation:AnimalsCells
  58. Bettini ML, Guy C, Dash P, Vignali KM, Hamm DE, Dobbins J, Gagnon E, Thomas PG, Wucherpfennig KW, Vignali DA. Membrane association of the CD3e signaling domain is required for optimal T cell development and function. J Immunol. 2014 Jul 01; 193(1):258-67. PMID: 24899501.
    Citations: 11     Fields:    Translation:AnimalsCells
  59. Kardava L, Moir S, Shah N, Wang W, Wilson R, Buckner CM, Santich BH, Kim LJ, Spurlin EE, Nelson AK, Wheatley AK, Harvey CJ, McDermott AB, Wucherpfennig KW, Chun TW, Tsang JS, Li Y, Fauci AS. Abnormal B cell memory subsets dominate HIV-specific responses in infected individuals. J Clin Invest. 2014 Jul; 124(7):3252-62. PMID: 24892810.
    Citations: 48     Fields:    Translation:HumansCells
  60. Birnbaum ME, Mendoza JL, Sethi DK, Dong S, Glanville J, Dobbins J, Ozkan E, Davis MM, Wucherpfennig KW, Garcia KC. Deconstructing the peptide-MHC specificity of T cell recognition. Cell. 2014 May 22; 157(5):1073-87. PMID: 24855945.
    Citations: 162     Fields:    Translation:HumansAnimalsCells
  61. Zhou P, Wucherpfennig KW. Discovering cancer immunotherapy targets in vivo. Oncoimmunology. 2014; 3:e28500. PMID: 25050218.
    Citations:    
  62. Elpek KG, Cremasco V, Shen H, Harvey CJ, Wucherpfennig KW, Goldstein DR, Monach PA, Turley SJ. The tumor microenvironment shapes lineage, transcriptional, and functional diversity of infiltrating myeloid cells. Cancer Immunol Res. 2014 Jul; 2(7):655-67. PMID: 24801837.
    Citations: 35     Fields:    Translation:AnimalsCells
  63. Choudhuri K, Llodrá J, Roth EW, Tsai J, Gordo S, Wucherpfennig KW, Kam LC, Stokes DL, Dustin ML. Polarized release of T-cell-receptor-enriched microvesicles at the immunological synapse. Nature. 2014 Mar 06; 507(7490):118-23. PMID: 24487619.
    Citations: 154     Fields:    Translation:HumansAnimalsCells
  64. Zhou P, Shaffer DR, Alvarez Arias DA, Nakazaki Y, Pos W, Torres AJ, Cremasco V, Dougan SK, Cowley GS, Elpek K, Brogdon J, Lamb J, Turley SJ, Ploegh HL, Root DE, Love JC, Dranoff G, Hacohen N, Cantor H, Wucherpfennig KW. In vivo discovery of immunotherapy targets in the tumour microenvironment. Nature. 2014 Feb 06; 506(7486):52-7. PMID: 24476824.
    Citations: 69     Fields:    Translation:AnimalsCells
  65. Pos W, Sethi DK, Wucherpfennig KW. Mechanisms of peptide repertoire selection by HLA-DM. Trends Immunol. 2013 Oct; 34(10):495-501. PMID: 23835076.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  66. Harvey CJ, Wucherpfennig KW. Cracking the code of human T-cell immunity. Nat Biotechnol. 2013 Jul; 31(7):609-10. PMID: 23839145.
    Citations: 3     Fields:    Translation:Humans
  67. Reardon DA, Wucherpfennig KW, Freeman G, Wu CJ, Chiocca EA, Wen PY, Curry WT, Mitchell DA, Fecci PE, Sampson JH, Dranoff G. An update on vaccine therapy and other immunotherapeutic approaches for glioblastoma. Expert Rev Vaccines. 2013 Jun; 12(6):597-615. PMID: 23750791.
    Citations: 28     Fields:    Translation:Humans
  68. Sethi DK, Gordo S, Schubert DA, Wucherpfennig KW. Crossreactivity of a human autoimmune TCR is dominated by a single TCR loop. Nat Commun. 2013; 4:2623. PMID: 24136005.
    Citations: 14     Fields:    Translation:HumansCells
  69. Pos W, Sethi DK, Call MJ, Schulze MS, Anders AK, Pyrdol J, Wucherpfennig KW. Crystal structure of the HLA-DM-HLA-DR1 complex defines mechanisms for rapid peptide selection. Cell. 2012 Dec 21; 151(7):1557-68. PMID: 23260142.
    Citations: 67     Fields:    Translation:HumansAnimalsCells
  70. Gagnon E, Schubert DA, Gordo S, Chu HH, Wucherpfennig KW. Local changes in lipid environment of TCR microclusters regulate membrane binding by the CD3e cytoplasmic domain. J Exp Med. 2012 Dec 17; 209(13):2423-39. PMID: 23166358.
    Citations: 40     Fields:    Translation:HumansCells
  71. Angin M, King M, Altfeld M, Walker BD, Wucherpfennig KW, Addo MM. Identification of HIV-1-specific regulatory T-cells using HLA class II tetramers. AIDS. 2012 Oct 23; 26(16):2112-5. PMID: 22874519.
    Citations: 11     Fields:    Translation:HumansCells
  72. Torres AJ, Contento RL, Gordo S, Wucherpfennig KW, Love JC. Functional single-cell analysis of T-cell activation by supported lipid bilayer-tethered ligands on arrays of nanowells. Lab Chip. 2013 Jan 07; 13(1):90-9. PMID: 23070211.
    Citations: 17     Fields:    Translation:HumansCells
  73. Janas MM, Wang B, Harris AS, Aguiar M, Shaffer JM, Subrahmanyam YV, Behlke MA, Wucherpfennig KW, Gygi SP, Gagnon E, Novina CD. Alternative RISC assembly: binding and repression of microRNA-mRNA duplexes by human Ago proteins. RNA. 2012 Nov; 18(11):2041-55. PMID: 23019594.
    Citations: 52     Fields:    Translation:HumansCells
  74. Acton SE, Astarita JL, Malhotra D, Lukacs-Kornek V, Franz B, Hess PR, Jakus Z, Kuligowski M, Fletcher AL, Elpek KG, Bellemare-Pelletier A, Sceats L, Reynoso ED, Gonzalez SF, Graham DB, Chang J, Peters A, Woodruff M, Kim YA, Swat W, Morita T, Kuchroo V, Carroll MC, Kahn ML, Wucherpfennig KW, Turley SJ. Podoplanin-rich stromal networks induce dendritic cell motility via activation of the C-type lectin receptor CLEC-2. Immunity. 2012 Aug 24; 37(2):276-89. PMID: 22884313.
    Citations: 88     Fields:    Translation:HumansAnimalsCells
  75. Schubert DA, Gordo S, Sabatino JJ, Vardhana S, Gagnon E, Sethi DK, Seth NP, Choudhuri K, Reijonen H, Nepom GT, Evavold BD, Dustin ML, Wucherpfennig KW. Self-reactive human CD4 T cell clones form unusual immunological synapses. J Exp Med. 2012 Feb 13; 209(2):335-52. PMID: 22312112.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  76. Peters A, Pitcher LA, Sullivan JM, Mitsdoerffer M, Acton SE, Franz B, Wucherpfennig K, Turley S, Carroll MC, Sobel RA, Bettelli E, Kuchroo VK. Th17 cells induce ectopic lymphoid follicles in central nervous system tissue inflammation. Immunity. 2011 Dec 23; 35(6):986-96. PMID: 22177922.
    Citations: 161     Fields:    Translation:AnimalsCells
  77. Schulze MS, Wucherpfennig KW. The mechanism of HLA-DM induced peptide exchange in the MHC class II antigen presentation pathway. Curr Opin Immunol. 2012 Feb; 24(1):105-11. PMID: 22138314.
    Citations: 24     Fields:    Translation:HumansAnimals
  78. Wucherpfennig KW, Noelle RJ. Autoimmune diseases have been the focus of intense research efforts. Curr Opin Immunol. 2011 Dec; 23(6):699-701. PMID: 22056155.
    Citations: 1     Fields:    Translation:HumansAnimals
  79. Wen F, Sethi DK, Wucherpfennig KW, Zhao H. Cell surface display of functional human MHC class II proteins: yeast display versus insect cell display. Protein Eng Des Sel. 2011 Sep; 24(9):701-9. PMID: 21752831.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  80. Franz B, May KF, Dranoff G, Wucherpfennig K. Ex vivo characterization and isolation of rare memory B cells with antigen tetramers. Blood. 2011 Jul 14; 118(2):348-57. PMID: 21551230.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  81. Wucherpfennig KW, Sethi D. T cell receptor recognition of self and foreign antigens in the induction of autoimmunity. Semin Immunol. 2011 Apr; 23(2):84-91. PMID: 21306912.
    Citations: 32     Fields:    Translation:HumansAnimals
  82. Lv H, Havari E, Pinto S, Gottumukkala RV, Cornivelli L, Raddassi K, Matsui T, Rosenzweig A, Bronson RT, Smith R, Fletcher AL, Turley SJ, Wucherpfennig K, Kyewski B, Lipes MA. Impaired thymic tolerance to a-myosin directs autoimmunity to the heart in mice and humans. J Clin Invest. 2011 Apr; 121(4):1561-73. PMID: 21436590.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  83. Li S, Moffett HF, Lu J, Werner L, Zhang H, Ritz J, Neuberg D, Wucherpfennig KW, Brown JR, Novina CD. MicroRNA expression profiling identifies activated B cell status in chronic lymphocytic leukemia cells. PLoS One. 2011 Mar 08; 6(3):e16956. PMID: 21408091.
    Citations: 31     Fields:    Translation:HumansCells
  84. Sethi DK, Schubert DA, Anders AK, Heroux A, Bonsor DA, Thomas CP, Sundberg EJ, Pyrdol J, Wucherpfennig KW. A highly tilted binding mode by a self-reactive T cell receptor results in altered engagement of peptide and MHC. J Exp Med. 2011 Jan 17; 208(1):91-102. PMID: 21199956.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  85. Anders AK, Call MJ, Schulze MS, Fowler KD, Schubert DA, Seth NP, Sundberg EJ, Wucherpfennig KW. HLA-DM captures partially empty HLA-DR molecules for catalyzed removal of peptide. Nat Immunol. 2011 Jan; 12(1):54-61. PMID: 21131964.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  86. Wucherpfennig KW. The first structures of T cell receptors bound to peptide-MHC. J Immunol. 2010 Dec 01; 185(11):6391-3. PMID: 21084667.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  87. Call ME, Wucherpfennig KW, Chou JJ. The structural basis for intramembrane assembly of an activating immunoreceptor complex. Nat Immunol. 2010 Nov; 11(11):1023-9. PMID: 20890284.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  88. Gagnon E, Xu C, Yang W, Chu HH, Call ME, Chou JJ, Wucherpfennig KW. Response multilayered control of T cell receptor phosphorylation. Cell. 2010 Sep 03; 142(5):669-71. PMID: 20813252.
    Citations: 11     Fields:    Translation:HumansCells
  89. Yi W, Seth NP, Martillotti T, Wucherpfennig KW, Sant'Angelo DB, Denzin LK. Targeted regulation of self-peptide presentation prevents type I diabetes in mice without disrupting general immunocompetence. J Clin Invest. 2010 Apr; 120(4):1324-36. PMID: 20200448.
    Citations: 36     Fields:    Translation:AnimalsCells
  90. Wucherpfennig KW, Gagnon E, Call MJ, Huseby ES, Call ME. Structural biology of the T-cell receptor: insights into receptor assembly, ligand recognition, and initiation of signaling. Cold Spring Harb Perspect Biol. 2010 Apr; 2(4):a005140. PMID: 20452950.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  91. Wucherpfennig KW, Gagnon E. Positively selecting peptides: their job does not end in the thymus. Nat Immunol. 2009 Nov; 10(11):1143-4. PMID: 19841646.
    Citations: 1     Fields:    Translation:Cells
  92. Wucherpfennig KW, Call MJ, Deng L, Mariuzza R. Structural alterations in peptide-MHC recognition by self-reactive T cell receptors. Curr Opin Immunol. 2009 Dec; 21(6):590-5. PMID: 19699075.
    Citations: 40     Fields:    Translation:HumansAnimals
  93. McLaughlin KA, Chitnis T, Newcombe J, Franz B, Kennedy J, McArdel S, Kuhle J, Kappos L, Rostasy K, Pohl D, Gagne D, Ness JM, Tenembaum S, O'Connor KC, Viglietta V, Wong SJ, Tavakoli NP, de Seze J, Idrissova Z, Khoury SJ, Bar-Or A, Hafler DA, Banwell B, Wucherpfennig KW. Age-dependent B cell autoimmunity to a myelin surface antigen in pediatric multiple sclerosis. J Immunol. 2009 Sep 15; 183(6):4067-76. PMID: 19687098.
    Citations: 68     Fields:    Translation:HumansCells
  94. Call MJ, Xing X, Cuny GD, Seth NP, Altmann DM, Fugger L, Krogsgaard M, Stein RL, Wucherpfennig KW. In vivo enhancement of peptide display by MHC class II molecules with small molecule catalysts of peptide exchange. J Immunol. 2009 May 15; 182(10):6342-52. PMID: 19414787.
    Citations: 16     Fields:    Translation:Animals
  95. Perone MJ, Bertera S, Shufesky WJ, Divito SJ, Montecalvo A, Mathers AR, Larregina AT, Pang M, Seth N, Wucherpfennig KW, Trucco M, Baum LG, Morelli AE. Suppression of autoimmune diabetes by soluble galectin-1. J Immunol. 2009 Mar 01; 182(5):2641-53. PMID: 19234158.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  96. Xu C, Gagnon E, Call ME, Schnell JR, Schwieters CD, Carman CV, Chou JJ, Wucherpfennig KW. Regulation of T cell receptor activation by dynamic membrane binding of the CD3epsilon cytoplasmic tyrosine-based motif. Cell. 2008 Nov 14; 135(4):702-13. PMID: 19013279.
    Citations: 186     Fields:    Translation:Cells
  97. Bowen DG, Shoukry NH, Grakoui A, Fuller MJ, Cawthon AG, Dong C, Hasselschwert DL, Brasky KM, Freeman GJ, Seth NP, Wucherpfennig KW, Houghton M, Walker CM. Variable patterns of programmed death-1 expression on fully functional memory T cells after spontaneous resolution of hepatitis C virus infection. J Virol. 2008 May; 82(10):5109-14. PMID: 18337576.
    Citations: 19     Fields:    Translation:AnimalsCells
  98. Verginis P, McLaughlin KA, Wucherpfennig KW, von Boehmer H, Apostolou I. Induction of antigen-specific regulatory T cells in wild-type mice: visualization and targets of suppression. Proc Natl Acad Sci U S A. 2008 Mar 04; 105(9):3479-84. PMID: 18299571.
    Citations: 42     Fields:    Translation:AnimalsCells
  99. McLaughlin KA, Wucherpfennig KW. B cells and autoantibodies in the pathogenesis of multiple sclerosis and related inflammatory demyelinating diseases. Adv Immunol. 2008; 98:121-49. PMID: 18772005.
    Citations: 30     Fields:    Translation:HumansCells
  100. Nose H, Kubota R, Seth NP, Goon PK, Tanaka Y, Izumo S, Usuku K, Ohara Y, Wucherpfennig KW, Bangham CR, Osame M, Saito M. Ex vivo analysis of human T lymphotropic virus type 1-specific CD4+ cells by use of a major histocompatibility complex class II tetramer composed of a neurological disease-susceptibility allele and its immunodominant peptide. J Infect Dis. 2007 Dec 15; 196(12):1761-72. PMID: 18190256.
    Citations: 8     Fields:    Translation:HumansCells
  101. Call ME, Wucherpfennig KW. Common themes in the assembly and architecture of activating immune receptors. Nat Rev Immunol. 2007 Nov; 7(11):841-50. PMID: 17960150.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  102. Grotenbreg GM, Nicholson MJ, Fowler KD, Wilbuer K, Octavio L, Yang M, Chakraborty AK, Ploegh HL, Wucherpfennig KW. Empty class II major histocompatibility complex created by peptide photolysis establishes the role of DM in peptide association. J Biol Chem. 2007 Jul 20; 282(29):21425-36. PMID: 17525157.
    Citations: 30     Fields:    Translation:HumansCells
  103. Garibyan L, Lobito AA, Siegel RM, Call ME, Wucherpfennig KW, Geha RS. Dominant-negative effect of the heterozygous C104R TACI mutation in common variable immunodeficiency (CVID). J Clin Invest. 2007 Jun; 117(6):1550-7. PMID: 17492055.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  104. Lu L, Ikizawa K, Hu D, Werneck MB, Wucherpfennig KW, Cantor H. Regulation of activated CD4+ T cells by NK cells via the Qa-1-NKG2A inhibitory pathway. Immunity. 2007 May; 26(5):593-604. PMID: 17509909.
    Citations: 89     Fields:    Translation:AnimalsCells
  105. Wucherpfennig KW, Allen PM, Celada F, Cohen IR, De Boer R, Garcia KC, Goldstein B, Greenspan R, Hafler D, Hodgkin P, Huseby ES, Krakauer DC, Nemazee D, Perelson AS, Pinilla C, Strong RK, Sercarz EE. Polyspecificity of T cell and B cell receptor recognition. Semin Immunol. 2007 Aug; 19(4):216-24. PMID: 17398114.
    Citations: 79     Fields:    Translation:HumansAnimalsCells
  106. Korn T, Reddy J, Gao W, Bettelli E, Awasthi A, Petersen TR, Bäckström BT, Sobel RA, Wucherpfennig KW, Strom TB, Oukka M, Kuchroo VK. Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation. Nat Med. 2007 Apr; 13(4):423-31. PMID: 17384649.
    Citations: 328     Fields:    Translation:AnimalsCells
  107. Moza B, Varma AK, Buonpane RA, Zhu P, Herfst CA, Nicholson MJ, Wilbuer AK, Seth NP, Wucherpfennig KW, McCormick JK, Kranz DM, Sundberg EJ. Structural basis of T-cell specificity and activation by the bacterial superantigen TSST-1. EMBO J. 2007 Feb 21; 26(4):1187-97. PMID: 17268555.
    Citations: 22     Fields:    Translation:HumansCells
  108. O'Connor KC, McLaughlin KA, De Jager PL, Chitnis T, Bettelli E, Xu C, Robinson WH, Cherry SV, Bar-Or A, Banwell B, Fukaura H, Fukazawa T, Tenembaum S, Wong SJ, Tavakoli NP, Idrissova Z, Viglietta V, Rostasy K, Pohl D, Dale RC, Freedman M, Steinman L, Buckle GJ, Kuchroo VK, Hafler DA, Wucherpfennig KW. Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein. Nat Med. 2007 Feb; 13(2):211-7. PMID: 17237795.
    Citations: 104     Fields:    Translation:HumansAnimalsCells
  109. Call ME, Schnell JR, Xu C, Lutz RA, Chou JJ, Wucherpfennig KW. The structure of the zetazeta transmembrane dimer reveals features essential for its assembly with the T cell receptor. Cell. 2006 Oct 20; 127(2):355-68. PMID: 17055436.
    Citations: 72     Fields:    Translation:HumansCells
  110. Xu C, Call ME, Wucherpfennig KW. A membrane-proximal tetracysteine motif contributes to assembly of CD3deltaepsilon and CD3gammaepsilon dimers with the T cell receptor. J Biol Chem. 2006 Dec 01; 281(48):36977-84. PMID: 17023417.
    Citations: 20     Fields:    Translation:HumansCells
  111. Ulsenheimer A, Lucas M, Seth NP, Tilman Gerlach J, Gruener NH, Loughry A, Pape GR, Wucherpfennig KW, Diepolder HM, Klenerman P. Transient immunological control during acute hepatitis C virus infection: ex vivo analysis of helper T-cell responses. J Viral Hepat. 2006 Oct; 13(10):708-14. PMID: 16970603.
    Citations: 16     Fields:    Translation:HumansCells
  112. Feng J, Call ME, Wucherpfennig KW. The assembly of diverse immune receptors is focused on a polar membrane-embedded interaction site. PLoS Biol. 2006 May; 4(5):e142. PMID: 16623599.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  113. Nicholson MJ, Moradi B, Seth NP, Xing X, Cuny GD, Stein RL, Wucherpfennig KW. Small molecules that enhance the catalytic efficiency of HLA-DM. J Immunol. 2006 Apr 01; 176(7):4208-20. PMID: 16547258.
    Citations: 27     Fields:    Translation:HumansCells
  114. Seth N, Kaufmann D, Lahey T, Rosenberg ES, Wucherpfennig KW. Expansion and contraction of HIV-specific CD4 T cells with short bursts of viremia, but physical loss of the majority of these cells with sustained viral replication. J Immunol. 2005 Nov 15; 175(10):6948-58. PMID: 16272355.
    Citations: 21     Fields:    Translation:HumansCells
  115. Reddy J, Waldner H, Zhang X, Illes Z, Wucherpfennig KW, Sobel RA, Kuchroo VK. Cutting edge: CD4+CD25+ regulatory T cells contribute to gender differences in susceptibility to experimental autoimmune encephalomyelitis. J Immunol. 2005 Nov 01; 175(9):5591-5. PMID: 16237044.
    Citations: 37     Fields:    Translation:AnimalsCells
  116. Nicholson MJ, Hahn M, Wucherpfennig KW. Unusual features of self-peptide/MHC binding by autoimmune T cell receptors. Immunity. 2005 Oct; 23(4):351-60. PMID: 16226501.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  117. O'Connor KC, Appel H, Bregoli L, Call ME, Catz I, Chan JA, Moore NH, Warren KG, Wong SJ, Hafler DA, Wucherpfennig KW. Antibodies from inflamed central nervous system tissue recognize myelin oligodendrocyte glycoprotein. J Immunol. 2005 Aug 01; 175(3):1974-82. PMID: 16034142.
    Citations: 48     Fields:    Translation:HumansCells
  118. Garrity D, Call ME, Feng J, Wucherpfennig KW. The activating NKG2D receptor assembles in the membrane with two signaling dimers into a hexameric structure. Proc Natl Acad Sci U S A. 2005 May 24; 102(21):7641-6. PMID: 15894612.
    Citations: 68     Fields:    Translation:HumansCells
  119. Hahn M, Nicholson MJ, Pyrdol J, Wucherpfennig KW. Unconventional topology of self peptide-major histocompatibility complex binding by a human autoimmune T cell receptor. Nat Immunol. 2005 May; 6(5):490-6. PMID: 15821740.
    Citations: 111     Fields:    Translation:HumansCells
  120. Feng J, Garrity D, Call ME, Moffett H, Wucherpfennig KW. Convergence on a distinctive assembly mechanism by unrelated families of activating immune receptors. Immunity. 2005 Apr; 22(4):427-38. PMID: 15845448.
    Citations: 32     Fields:    Translation:AnimalsCells
  121. Wucherpfennig KW. The structural interactions between T cell receptors and MHC-peptide complexes place physical limits on self-nonself discrimination. Curr Top Microbiol Immunol. 2005; 296:19-37. PMID: 16329190.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  122. Call ME, Wucherpfennig KW. The T cell receptor: critical role of the membrane environment in receptor assembly and function. Annu Rev Immunol. 2005; 23:101-25. PMID: 15771567.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  123. Appel H, Kuon W, Kuhne M, Hülsmeyer M, Kollnberger S, Kuhlmann S, Weiss E, Zeitz M, Wucherpfennig K, Bowness P, Sieper J. The solvent-inaccessible Cys67 residue of HLA-B27 contributes to T cell recognition of HLA-B27/peptide complexes. J Immunol. 2004 Dec 01; 173(11):6564-73. PMID: 15557146.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  124. Haining WN, Evans JW, Seth NP, Callaway GD, Wucherpfennig KW, Nadler LM, Guinan EC. Measuring T cell immunity to influenza vaccination in children after haemopoietic stem cell transplantation. Br J Haematol. 2004 Nov; 127(3):322-5. PMID: 15491293.
    Citations: 7     Fields:    Translation:HumansCells
  125. Reddy J, Illes Z, Zhang X, Encinas J, Pyrdol J, Nicholson L, Sobel RA, Wucherpfennig KW, Kuchroo VK. Myelin proteolipid protein-specific CD4+CD25+ regulatory cells mediate genetic resistance to experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 2004 Oct 26; 101(43):15434-9. PMID: 15492218.
    Citations: 83     Fields:    Translation:AnimalsCells
  126. Tian C, Bagley J, Cretin N, Seth N, Wucherpfennig KW, Iacomini J. Prevention of type 1 diabetes by gene therapy. J Clin Invest. 2004 Oct; 114(7):969-78. PMID: 15467836.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  127. Ferlin WG, Mougneau E, Hugues S, Appel H, Jang MH, Cazareth J, Beaudoin L, Schricke C, Lehuen A, Wucherpfennig KW, Glaichenhaus N. Self-peptides that bind with low affinity to the diabetes-associated I-A(g7) molecule readily induce T cell tolerance in non-obese diabetic mice. Eur J Immunol. 2004 Oct; 34(10):2656-63. PMID: 15368281.
    Citations: 5     Fields:    Translation:AnimalsCells
  128. Mycko MP, Waldner H, Anderson DE, Bourcier KD, Wucherpfennig KW, Kuchroo VK, Hafler DA. Cross-reactive TCR responses to self antigens presented by different MHC class II molecules. J Immunol. 2004 Aug 01; 173(3):1689-98. PMID: 15265898.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  129. Havari E, Lennon-Dumenil AM, Klein L, Neely D, Taylor JA, McInerney MF, Wucherpfennig KW, Lipes MA. Expression of the B7.1 costimulatory molecule on pancreatic beta cells abrogates the requirement for CD4 T cells in the development of type 1 diabetes. J Immunol. 2004 Jul 15; 173(2):787-96. PMID: 15240665.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  130. Call ME, Pyrdol J, Wucherpfennig KW. Stoichiometry of the T-cell receptor-CD3 complex and key intermediates assembled in the endoplasmic reticulum. EMBO J. 2004 Jun 16; 23(12):2348-57. PMID: 15152191.
    Citations: 34     Fields:    Translation:Cells
  131. Panoutsakopoulou V, Huster KM, McCarty N, Feinberg E, Wang R, Wucherpfennig KW, Cantor H. Suppression of autoimmune disease after vaccination with autoreactive T cells that express Qa-1 peptide complexes. J Clin Invest. 2004 Apr; 113(8):1218-24. PMID: 15085201.
    Citations: 24     Fields:    Translation:AnimalsCellsPHPublic Health
  132. Call ME, Wucherpfennig KW. Molecular mechanisms for the assembly of the T cell receptor-CD3 complex. Mol Immunol. 2004 Apr; 40(18):1295-305. PMID: 15072848.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  133. Taylor JA, Havari E, McInerney MF, Bronson R, Wucherpfennig KW, Lipes MA. A spontaneous model for autoimmune myocarditis using the human MHC molecule HLA-DQ8. J Immunol. 2004 Feb 15; 172(4):2651-8. PMID: 14764740.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  134. Wucherpfennig KW. T cell receptor crossreactivity as a general property of T cell recognition. Mol Immunol. 2004 Feb; 40(14-15):1009-17. PMID: 15036904.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  135. Wucherpfennig KW. Presentation of a self-peptide in two distinct conformations by a disease-associated HLA-B27 subtype. J Exp Med. 2004 Jan 19; 199(2):151-4. PMID: 14734520.
    Citations: 5     Fields:    Translation:HumansCells
  136. Berretta F, Butler RH, Diaz G, Sanarico N, Arroyo J, Fraziano M, Aichinger G, Wucherpfennig KW, Colizzi V, Saltini C, Amicosante M. Detailed analysis of the effects of Glu/Lys beta69 human leukocyte antigen-DP polymorphism on peptide-binding specificity. Tissue Antigens. 2003 Dec; 62(6):459-71. PMID: 14617029.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  137. Wucherpfennig KW. MHC-linked susceptibility to type 1 diabetes: a structural perspective. Ann N Y Acad Sci. 2003 Nov; 1005:119-27. PMID: 14679046.
    Citations: 9     Fields:    Translation:AnimalsCells
  138. Jang MH, Seth NP, Wucherpfennig KW. Ex vivo analysis of thymic CD4 T cells in nonobese diabetic mice with tetramers generated from I-A(g7)/class II-associated invariant chain peptide precursors. J Immunol. 2003 Oct 15; 171(8):4175-86. PMID: 14530340.
    Citations: 23     Fields:    Translation:AnimalsCells
  139. Day CL, Seth NP, Lucas M, Appel H, Gauthier L, Lauer GM, Robbins GK, Szczepiorkowski ZM, Casson DR, Chung RT, Bell S, Harcourt G, Walker BD, Klenerman P, Wucherpfennig KW. Ex vivo analysis of human memory CD4 T cells specific for hepatitis C virus using MHC class II tetramers. J Clin Invest. 2003 Sep; 112(6):831-42. PMID: 12975468.
    Citations: 121     Fields:    Translation:HumansAnimalsCells
  140. Maecker B, Sherr DH, Vonderheide RH, von Bergwelt-Baildon MS, Hirano N, Anderson KS, Xia Z, Butler MO, Wucherpfennig KW, O'Hara C, Cole G, Kwak SS, Ramstedt U, Tomlinson AJ, Chicz RM, Nadler LM, Schultze JL. The shared tumor-associated antigen cytochrome P450 1B1 is recognized by specific cytotoxic T cells. Blood. 2003 Nov 01; 102(9):3287-94. PMID: 12869499.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  141. O'Connor KC, Chitnis T, Griffin DE, Piyasirisilp S, Bar-Or A, Khoury S, Wucherpfennig KW, Hafler DA. Myelin basic protein-reactive autoantibodies in the serum and cerebrospinal fluid of multiple sclerosis patients are characterized by low-affinity interactions. J Neuroimmunol. 2003 Mar; 136(1-2):140-8. PMID: 12620653.
    Citations: 27     Fields:    Translation:HumansCells
  142. Reddy J, Bettelli E, Nicholson L, Waldner H, Jang MH, Wucherpfennig KW, Kuchroo VK. Detection of autoreactive myelin proteolipid protein 139-151-specific T cells by using MHC II (IAs) tetramers. J Immunol. 2003 Jan 15; 170(2):870-7. PMID: 12517952.
    Citations: 31     Fields:    Translation:AnimalsCells
  143. Call ME, Pyrdol J, Wiedmann M, Wucherpfennig KW. The organizing principle in the formation of the T cell receptor-CD3 complex. Cell. 2002 Dec 27; 111(7):967-79. PMID: 12507424.
    Citations: 136     Fields:    Translation:HumansCells
  144. Belmares MP, Busch R, Wucherpfennig KW, McConnell HM, Mellins ED. Structural factors contributing to DM susceptibility of MHC class II/peptide complexes. J Immunol. 2002 Nov 01; 169(9):5109-17. PMID: 12391227.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  145. Lang HL, Jacobsen H, Ikemizu S, Andersson C, Harlos K, Madsen L, Hjorth P, Sondergaard L, Svejgaard A, Wucherpfennig K, Stuart DI, Bell JI, Jones EY, Fugger L. A functional and structural basis for TCR cross-reactivity in multiple sclerosis. Nat Immunol. 2002 Oct; 3(10):940-3. PMID: 12244309.
    Citations: 141     Fields:    Translation:HumansAnimalsCells
  146. von Bergwelt-Baildon MS, Vonderheide RH, Maecker B, Hirano N, Anderson KS, Butler MO, Xia Z, Zeng WY, Wucherpfennig KW, Nadler LM, Schultze JL. Human primary and memory cytotoxic T lymphocyte responses are efficiently induced by means of CD40-activated B cells as antigen-presenting cells: potential for clinical application. Blood. 2002 May 01; 99(9):3319-25. PMID: 11964299.
    Citations: 60     Fields:    Translation:HumansCells
  147. Wucherpfennig KW. Infectious triggers for inflammatory neurological diseases. Nat Med. 2002 May; 8(5):455-7. PMID: 11984586.
    Citations: 5     Fields:    Translation:HumansCells
  148. Wucherpfennig KW. Insights into autoimmunity gained from structural analysis of MHC-peptide complexes. Curr Opin Immunol. 2001 Dec; 13(6):650-6. PMID: 11677085.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  149. Vonderheide RH, Schultze JL, Anderson KS, Maecker B, Butler MO, Xia Z, Kuroda MJ, von Bergwelt-Baildon MS, Bedor MM, Hoar KM, Schnipper DR, Brooks MW, Letvin NL, Stephans KF, Wucherpfennig KW, Hahn WC, Nadler LM. Equivalent induction of telomerase-specific cytotoxic T lymphocytes from tumor-bearing patients and healthy individuals. Cancer Res. 2001 Dec 01; 61(23):8366-70. PMID: 11731409.
    Citations: 17     Fields:    Translation:HumansCells
  150. Bourcier KD, Lim DG, Ding YH, Smith KJ, Wucherpfennig K, Hafler DA. Conserved CDR3 regions in T-cell receptor (TCR) CD8(+) T cells that recognize the Tax11-19/HLA-A*0201 complex in a subject infected with human T-cell leukemia virus type 1: relationship of T-cell fine specificity and major histocompatibility complex/peptide/TCR crystal structure. J Virol. 2001 Oct; 75(20):9836-43. PMID: 11559817.
    Citations: 10     Fields:    Translation:HumansCells
  151. Wucherpfennig KW. Mechanisms for the induction of autoimmunity by infectious agents. J Clin Invest. 2001 Oct; 108(8):1097-104. PMID: 11602615.
    Citations: 87     Fields:    Translation:HumansAnimalsCells
  152. Wucherpfennig KW, Eisenbarth GS. Type 1 diabetes. Nat Immunol. 2001 Sep; 2(9):767-8. PMID: 11526380.
    Citations: 7     Fields:    Translation:HumansAnimals
  153. Panoutsakopoulou V, Sanchirico ME, Huster KM, Jansson M, Granucci F, Shim DJ, Wucherpfennig KW, Cantor H. Analysis of the relationship between viral infection and autoimmune disease. Immunity. 2001 Jul; 15(1):137-47. PMID: 11485745.
    Citations: 28     Fields:    Translation:AnimalsCells
  154. Lee KH, Wucherpfennig KW, Wiley DC. Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes. Nat Immunol. 2001 Jun; 2(6):501-7. PMID: 11376336.
    Citations: 117     Fields:    Translation:HumansAnimalsCells
  155. Wucherpfennig KW. Structural basis of molecular mimicry. J Autoimmun. 2001 May; 16(3):293-302. PMID: 11334495.
    Citations: 19     Fields:    Translation:HumansCells
  156. Appel H, Seth NP, Gauthier L, Wucherpfennig KW. Anergy induction by dimeric TCR ligands. J Immunol. 2001 Apr 15; 166(8):5279-85. PMID: 11290814.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  157. Malherbe L, Filippi C, Julia V, Foucras G, Moro M, Appel H, Wucherpfennig K, Guéry JC, Glaichenhaus N. Selective activation and expansion of high-affinity CD4+ T cells in resistant mice upon infection with Leishmania major. Immunity. 2000 Dec; 13(6):771-82. PMID: 11163193.
    Citations: 34     Fields:    Translation:AnimalsCells
  158. Yu B, Gauthier L, Hausmann DH, Wucherpfennig KW. Binding of conserved islet peptides by human and murine MHC class II molecules associated with susceptibility to type I diabetes. Eur J Immunol. 2000 Sep; 30(9):2497-506. PMID: 11009082.
    Citations: 23 &