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profileStaci Ann Gruber, Ph.D.

TitleAssociate Professor of Psychiatry
InstitutionMcLean Hospital
DepartmentPsychiatry
AddressMclean Hospital
Neuroimaging Center, 148
115 Mill St
Belmont MA 02478
Phone617/855-2762
Fax617/855-3713
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2009Alfred Pope Award for Young Investigators

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01DA032646     (GRUBER, STACI A)May 1, 2012 - Mar 31, 2017
NIH/NIDA
Marijuana: Neurobiologic Correlates of Age of Onset
Role: Principal Investigator

R21DA021241     (GRUBER, STACI A)Sep 1, 2007 - Aug 31, 2010
NIH/NIDA
Marijuana and Mood: Frontal Predictors of Behavior
Role: Principal Investigator

R03DA016695     (GRUBER, STACI A)Jul 15, 2003 - Jul 30, 2005
NIH/NIDA
Frontal Neural Mechanisms and Risk for Substance Abuse
Role: Principal Investigator

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Sagar KA, Dahlgren MK, Racine MT, Dreman MW, Olson DP, Gruber SA. Joint Effects: A Pilot Investigation of the Impact of Bipolar Disorder and Marijuana Use on Cognitive Function and Mood. PLoS One. 2016; 11(6):e0157060. PMID: 27275781.
    View in: PubMed
  2. Dahlgren MK, Sagar KA, Racine MT, Dreman MW, Gruber SA. Marijuana Use Predicts Cognitive Performance on Tasks of Executive Function. J Stud Alcohol Drugs. 2016 Mar; 77(2):298-308. PMID: 26997188.
    View in: PubMed
  3. Baskin-Sommers AR, Hooley JM, Dahlgren MK, Gönenc A, Yurgelun-Todd DA, Gruber SA. Elevated Preattentive Affective Processing in Individuals with Borderline Personality Disorder: A Preliminary fMRI Study. Front Psychol. 2015; 6:1866. PMID: 26696932.
    View in: PubMed
  4. Gruber SA, Sagar KA, Dahlgren MK, Gonenç A, Conn NA, Winer JP, Penetar D, Lukas SE. Citicoline Treatment Improves Measures of Impulsivity and Task Performance in Chronic Marijuana Smokers: A Pilot BOLD fMRI Study. Int J Neurol Neurother. 2015 Sep 30; 2(3):1-8. PMID: 26658924.
    View in: PubMed
  5. Gruber SA, Dahlgren MK, Sagar KA, Gönenç A, Lukas SE. Worth the wait: effects of age of onset of marijuana use on white matter and impulsivity. Psychopharmacology (Berl). 2014 Apr; 231(8):1455-65. PMID: 24190588; PMCID: PMC3967072.
  6. Sagar KA, Dahlgren MK, Gönenç A, Gruber SA. Altered affective processing in bipolar disorder: an fMRI study. J Affect Disord. 2013 Sep 25; 150(3):1192-6. PMID: 23726779; PMCID: PMC3922285.
  7. Sneider JT, Gruber SA, Rogowska J, Silveri MM, Yurgelun-Todd DA. A preliminary study of functional brain activation among marijuana users during performance of a virtual water maze task. J Addict. 2013; 2013:461029. PMID: 23951549.
    View in: PubMed
  8. Hooley JM, Siegle G, Gruber SA. Affective and neural reactivity to criticism in individuals high and low on perceived criticism. PLoS One. 2012; 7(9):e44412. PMID: 22984504; PMCID: PMC3439418.
  9. Gruber SA, Dahlgren MK, Sagar KA, Gönenc A, Killgore WD. Age of onset of marijuana use impacts inhibitory processing. Neurosci Lett. 2012 Mar 9; 511(2):89-94. PMID: 22306089; PMCID: PMC3659423.
  10. Gruber SA, Sagar KA, Dahlgren MK, Olson DP, Centorrino F, Lukas SE. Marijuana impacts mood in bipolar disorder: a pilot study. Mental Health and Substance Use. 2012; 1-12.
  11. Gruber SA, Sagar KA, Dahlgren MK, Racine M, Lukas SE. Age of onset of marijuana use and executive function. Psychol Addict Behav. 2012 Sep; 26(3):496-506. PMID: 22103843; PMCID: PMC3345171.
  12. Gruber SA, Silveri MM, Dahlgren MK, Yurgelun-Todd D. Why so impulsive? White matter alterations are associated with impulsivity in chronic marijuana smokers. Exp Clin Psychopharmacol. 2011 Jun; 19(3):231-42. PMID: 21480730; PMCID: PMC3659424.
  13. Halpern JH, Sherwood AR, Hudson JI, Gruber S, Kozin D, Pope HG. Residual neurocognitive features of long-term ecstasy users with minimal exposure to other drugs. Addiction. 2011 Apr; 106(4):777-86. PMID: 21205042; PMCID: PMC3053129.
  14. Hooley JM, Gruber SA, Parker HA, Guillaumot J, Rogowska J, Yurgelun-Todd DA. Neural processing of emotional overinvolvement in borderline personality disorder. J Clin Psychiatry. 2010 Aug; 71(8):1017-24. PMID: 20361894.
    View in: PubMed
  15. Gruber SA, Rogowska J, Yurgelun-Todd DA. Altered affective response in marijuana smokers: an FMRI study. Drug Alcohol Depend. 2009 Nov 1; 105(1-2):139-53. PMID: 19656642; PMCID: PMC2752701.
  16. Hooley JM, Gruber SA, Parker HA, Guillaumot J, Rogowska J, Yurgelun-Todd DA. Cortico-limbic response to personally challenging emotional stimuli after complete recovery from depression. Psychiatry Res. 2009 Apr 30; 172(1):83-91. PMID: 19452633.
    View in: PubMed
  17. Killgore WD, Rosso IM, Gruber SA, Yurgelun-Todd DA. Amygdala volume and verbal memory performance in schizophrenia and bipolar disorder. Cogn Behav Neurol. 2009 Mar; 22(1):28-37. PMID: 19372768.
    View in: PubMed
  18. Bogner W, Gruber S, Doelken M, Stadlbauer A, Ganslandt O, Boettcher U, Trattnig S, Doerfler A, Stefan H, Hammen T. In vivo quantification of intracerebral GABA by single-voxel (1)H-MRS-How reproducible are the results? Eur J Radiol. 2010 Mar; 73(3):526-31. PMID: 19201120.
    View in: PubMed
  19. Hooley JM, Gruber SA, Parker HA, Guillaumot J, Rogowska J, Yurgelun-Todd DA. Cortico-limbic response to personally challenging emotional stimuli after complete recovery from depression. Psychiatry Res. 2009 Feb 28; 171(2):106-19. PMID: 19176279.
    View in: PubMed
  20. Killgore WD, Gruber SA, Yurgelun-Todd DA. Abnormal corticostriatal activity during fear perception in bipolar disorder. Neuroreport. 2008 Oct 8; 19(15):1523-7. PMID: 18797310; PMCID: PMC2667943.
  21. Chen Y, Grossman ED, Bidwell LC, Yurgelun-Todd D, Gruber SA, Levy DL, Nakayama K, Holzman PS. Differential activation patterns of occipital and prefrontal cortices during motion processing: evidence from normal and schizophrenic brains. Cogn Affect Behav Neurosci. 2008 Sep; 8(3):293-303. PMID: 18814466; PMCID: PMC2572781.
  22. Sneider JT, Pope HG, Silveri MM, Simpson NS, Gruber SA, Yurgelun-Todd DA. Differences in regional blood volume during a 28-day period of abstinence in chronic cannabis smokers. Eur Neuropsychopharmacol. 2008 Aug; 18(8):612-9. PMID: 18571388; PMCID: PMC2518664.
  23. Yurgelun-Todd DA, Rogowska J, Gruber SA, Bogorodzki P, Simpson NS, Irvin RW, Jauregui KA, Strong RA, Rusche JR. Increased amygdala fMRI activation after secretin administration. Exp Clin Psychopharmacol. 2008 Jun; 16(3):191-8. PMID: 18540778.
    View in: PubMed
  24. Pillay SS, Rogowska J, Kanayama G, Gruber S, Simpson N, Pope HG, Yurgelun-Todd DA. Cannabis and motor function: fMRI changes following 28 days of discontinuation. Exp Clin Psychopharmacol. 2008 Feb; 16(1):22-32. PMID: 18266549.
    View in: PubMed
  25. Gruber S, Pinker K, Riederer F, Chmelík M, Stadlbauer A, Bittsanský M, Mlynárik V, Frey R, Serles W, Bodamer O, Moser E. Metabolic changes in the normal ageing brain: consistent findings from short and long echo time proton spectroscopy. Eur J Radiol. 2008 Nov; 68(2):320-7. PMID: 17964104.
    View in: PubMed
  26. Gruber SA, Silveri MM, Yurgelun-Todd DA. Neuropsychological consequences of opiate use. Neuropsychol Rev. 2007 Sep; 17(3):299-315. PMID: 17690984.
    View in: PubMed
  27. Yurgelun-Todd DA, Silveri MM, Gruber SA, Rohan ML, Pimentel PJ. White matter abnormalities observed in bipolar disorder: a diffusion tensor imaging study. Bipolar Disord. 2007 Aug; 9(5):504-12. PMID: 17680921.
    View in: PubMed
  28. Streeter CC, Terhune DB, Whitfield TH, Gruber S, Sarid-Segal O, Silveri MM, Tzilos G, Afshar M, Rouse ED, Tian H, Renshaw PF, Ciraulo DA, Yurgelun-Todd DA. Performance on the Stroop predicts treatment compliance in cocaine-dependent individuals. Neuropsychopharmacology. 2008 Mar; 33(4):827-36. PMID: 17568399.
    View in: PubMed
  29. Gruber SA, Rosso IM, Yurgelun-Todd D. Neuropsychological performance predicts clinical recovery in bipolar patients. J Affect Disord. 2008 Jan; 105(1-3):253-60. PMID: 17524493; PMCID: PMC3271707.
  30. Killgore WD, Gruber SA, Yurgelun-Todd DA. Depressed mood and lateralized prefrontal activity during a Stroop task in adolescent children. Neurosci Lett. 2007 Apr 6; 416(1):43-8. PMID: 17350756; PMCID: PMC1964792.
  31. Stadlbauer A, Nimsky C, Gruber S, Moser E, Hammen T, Engelhorn T, Buchfelder M, Ganslandt O. Changes in fiber integrity, diffusivity, and metabolism of the pyramidal tract adjacent to gliomas: a quantitative diffusion tensor fiber tracking and MR spectroscopic imaging study. AJNR Am J Neuroradiol. 2007 Mar; 28(3):462-9. PMID: 17353313.
    View in: PubMed
  32. Hijioka S, Ikari T, Kamei A, Takano K, Asahara S, Fujita N, Shimizu M, Yamamoto J, Fujita R, Sasaki K. CT and MRI findings with contrast enhancement of small pancreatic adenocarcinoma in the late phase. Hepatogastroenterology. 2007 Mar; 54(74):389-92. PMID: 17523281.
    View in: PubMed
  33. Rosso IM, Killgore WD, Cintron CM, Gruber SA, Tohen M, Yurgelun-Todd DA. Reduced amygdala volumes in first-episode bipolar disorder and correlation with cerebral white matter. Biol Psychiatry. 2007 Mar 15; 61(6):743-9. PMID: 17123471.
    View in: PubMed
  34. Sneider JT, Pope HG, Silveri MM, Simpson NS, Gruber SA, Yurgelun-Todd DA. Altered regional blood volume in chronic cannabis smokers. Exp Clin Psychopharmacol. 2006 Nov; 14(4):422-8. PMID: 17115869.
    View in: PubMed
  35. Pillay SS, Rogowska J, Gruber SA, Simpson N, Yurgelun-Todd DA. Recognition of happy facial affect in panic disorder: an fMRI study. J Anxiety Disord. 2007; 21(3):381-93. PMID: 16860973.
    View in: PubMed
  36. Pillay SS, Gruber SA, Rogowska J, Simpson N, Yurgelun-Todd DA. fMRI of fearful facial affect recognition in panic disorder: the cingulate gyrus-amygdala connection. J Affect Disord. 2006 Aug; 94(1-3):173-81. PMID: 16782207.
    View in: PubMed
  37. Silveri MM, Rohan ML, Pimentel PJ, Gruber SA, Rosso IM, Yurgelun-Todd DA. Sex differences in the relationship between white matter microstructure and impulsivity in adolescents. Magn Reson Imaging. 2006 Sep; 24(7):833-41. PMID: 16916700.
    View in: PubMed
  38. Gruber SA, Tzilos GK, Silveri MM, Pollack M, Renshaw PF, Kaufman MJ, Yurgelun-Todd DA. Methadone maintenance improves cognitive performance after two months of treatment. Exp Clin Psychopharmacol. 2006 May; 14(2):157-64. PMID: 16756419.
    View in: PubMed
  39. Joffe H, Hall JE, Gruber S, Sarmiento IA, Cohen LS, Yurgelun-Todd D, Martin KA. Estrogen therapy selectively enhances prefrontal cognitive processes: a randomized, double-blind, placebo-controlled study with functional magnetic resonance imaging in perimenopausal and recently postmenopausal women. Menopause. 2006 May-Jun; 13(3):411-22. PMID: 16735938.
    View in: PubMed
  40. Gruber SA, Yurgelun-Todd DA. Neuroimaging of marijuana smokers during inhibitory processing: a pilot investigation. Brain Res Cogn Brain Res. 2005 Apr; 23(1):107-18. PMID: 15795138.
    View in: PubMed
  41. Hooley JM, Gruber SA, Scott LA, Hiller JB, Yurgelun-Todd DA. Activation in dorsolateral prefrontal cortex in response to maternal criticism and praise in recovered depressed and healthy control participants. Biol Psychiatry. 2005 Apr 1; 57(7):809-12. PMID: 15820239.
    View in: PubMed
  42. Yurgelun-Todd DA, Coyle JT, Gruber SA, Renshaw PF, Silveri MM, Amico E, Cohen B, Goff DC. Functional magnetic resonance imaging studies of schizophrenic patients during word production: effects of D-cycloserine. Psychiatry Res. 2005 Jan 30; 138(1):23-31. PMID: 15708298.
    View in: PubMed
  43. Pillay SS, Rogowska J, Kanayama G, Jon DI, Gruber S, Simpson N, Cherayil M, Pope HG, Yurgelun-Todd DA. Neurophysiology of motor function following cannabis discontinuation in chronic cannabis smokers: an fMRI study. Drug Alcohol Depend. 2004 Dec 7; 76(3):261-71. PMID: 15561477.
    View in: PubMed
  44. Gruber SA, Rogowska J, Yurgelun-Todd DA. Decreased activation of the anterior cingulate in bipolar patients: an fMRI study. J Affect Disord. 2004 Oct 15; 82(2):191-201. PMID: 15488247.
    View in: PubMed
  45. Kanayama G, Rogowska J, Pope HG, Gruber SA, Yurgelun-Todd DA. Spatial working memory in heavy cannabis users: a functional magnetic resonance imaging study. Psychopharmacology (Berl). 2004 Nov; 176(3-4):239-47. PMID: 15205869.
    View in: PubMed
  46. Rogowska J, Gruber SA, Yurgelun-Todd DA. Functional magnetic resonance imaging in schizophrenia: cortical response to motor stimulation. Psychiatry Res. 2004 Apr 30; 130(3):227-43. PMID: 15135157.
    View in: PubMed
  47. Ke Y, Streeter CC, Nassar LE, Sarid-Segal O, Hennen J, Yurgelun-Todd DA, Awad LA, Rendall MJ, Gruber SA, Nason A, Mudrick MJ, Blank SR, Meyer AA, Knapp C, Ciraulo DA, Renshaw PF. Frontal lobe GABA levels in cocaine dependence: a two-dimensional, J-resolved magnetic resonance spectroscopy study. Psychiatry Res. 2004 Apr 30; 130(3):283-93. PMID: 15135161.
    View in: PubMed
  48. Bodamer OA, Gruber S, Stöckler-Ipsiroglu S. Nuclear magnetic resonance spectroscopy in glutaryl-CoA dehydrogenase deficiency. J Inherit Metab Dis. 2004; 27(6):877-83. PMID: 15505395.
    View in: PubMed
  49. Gruber SA, Rogowska J, Holcomb P, Soraci S, Yurgelun-Todd D. Stroop performance in normal control subjects: an fMRI study. Neuroimage. 2002 Jun; 16(2):349-60. PMID: 12030821.
    View in: PubMed
  50. Babb SM, Wald LL, Cohen BM, Villafuerte RA, Gruber SA, Yurgelun-Todd DA, Renshaw PF. Chronic citicoline increases phosphodiesters in the brains of healthy older subjects: an in vivo phosphorus magnetic resonance spectroscopy study. Psychopharmacology (Berl). 2002 May; 161(3):248-54. PMID: 12021827.
    View in: PubMed
  51. Loeber RT, Gruber SA, Cohen BM, Renshaw PF, Sherwood AR, Yurgelun-Todd DA. Cerebellar blood volume in bipolar patients correlates with medication. Biol Psychiatry. 2002 Mar 1; 51(5):370-6. PMID: 11904131.
    View in: PubMed
  52. Nomikos GG, Gruber S, Svensson TH, Mathé AA. Effects of acute and chronic electroconvulsive stimuli on cAMP and cGMP efflux in the rat striatum and hippocampus. Eur Neuropsychopharmacol. 2000 Dec; 10(6):495-500. PMID: 11115740.
    View in: PubMed
  53. Yurgelun-Todd DA, Gruber SA, Kanayama G, Killgore WD, Baird AA, Young AD. fMRI during affect discrimination in bipolar affective disorder. Bipolar Disord. 2000 Sep; 2(3 Pt 2):237-48. PMID: 11249801.
    View in: PubMed
  54. Moore CM, Breeze JL, Gruber SA, Babb SM, Frederick BB, Villafuerte RA, Stoll AL, Hennen J, Yurgelun-Todd DA, Cohen BM, Renshaw PF. Choline, myo-inositol and mood in bipolar disorder: a proton magnetic resonance spectroscopic imaging study of the anterior cingulate cortex. Bipolar Disord. 2000 Sep; 2(3 Pt 2):207-16. PMID: 11249799.
    View in: PubMed
  55. Christensen JD, Yurgelun-Todd DA, Babb SM, Gruber SA, Cohen BM, Renshaw PF. Measurement of human brain dexfenfluramine concentration by 19F magnetic resonance spectroscopy. Brain Res. 1999 Jul 10; 834(1-2):1-5. PMID: 10407087.
    View in: PubMed
  56. Baird AA, Gruber SA, Fein DA, Maas LC, Steingard RJ, Renshaw PF, Cohen BM, Yurgelun-Todd DA. Functional magnetic resonance imaging of facial affect recognition in children and adolescents. J Am Acad Child Adolesc Psychiatry. 1999 Feb; 38(2):195-9. PMID: 9951219.
    View in: PubMed
  57. Levine JB, Gruber SA, Baird AA, Yurgelun-Todd D. Obsessive-compulsive disorder among schizophrenic patients: an exploratory study using functional magnetic resonance imaging data. Compr Psychiatry. 1998 Sep-Oct; 39(5):308-11. PMID: 9777284.
    View in: PubMed
  58. Pope HG, Jacobs A, Mialet JP, Yurgelun-Todd D, Gruber S. Evidence for a sex-specific residual effect of cannabis on visuospatial memory. Psychother Psychosom. 1997; 66(4):179-84. PMID: 9259040.
    View in: PubMed
  59. Yurgelun-Todd DA, Renshaw PF, Gruber SA, Ed M, Waternaux C, Cohen BM. Proton magnetic resonance spectroscopy of the temporal lobes in schizophrenics and normal controls. Schizophr Res. 1996 Mar; 19(1):55-9. PMID: 9147496.
    View in: PubMed
  60. Yurgelun-Todd DA, Waternaux CM, Cohen BM, Gruber SA, English CD, Renshaw PF. Functional magnetic resonance imaging of schizophrenic patients and comparison subjects during word production. Am J Psychiatry. 1996 Feb; 153(2):200-5. PMID: 8561199.
    View in: PubMed
  61. Kouri E, Pope HG, Yurgelun-Todd D, Gruber S. Attributes of heavy vs. occasional marijuana smokers in a college population. Biol Psychiatry. 1995 Oct 1; 38(7):475-81. PMID: 8672609.
    View in: PubMed
  62. Renshaw PF, Yurgelun-Todd DA, Tohen M, Gruber S, Cohen BM. Temporal lobe proton magnetic resonance spectroscopy of patients with first-episode psychosis. Am J Psychiatry. 1995 Mar; 152(3):444-6. PMID: 7864274.
    View in: PubMed
  63. Gruber SA, Gillingham K, Sothern RB, Stephanian E, Matas AJ, Dunn DL. De novo cancer in cyclosporine-treated and non-cyclosporine-treated adult primary renal allograft recipients. Clin Transplant. 1994 Aug; 8(4):388-95. PMID: 7949545.
    View in: PubMed
  64. Shapiro V, Adelson E, Tableman B. A model for the introduction of infant mental health services to community mental health agencies. J Am Acad Child Psychiatry. 1978; 17(2):348-55. PMID: 659751.
    View in: PubMed
  65. Stamm O, Latscha U, Janecek P, Campana A. Development of a special electrode for continuous subcutaneous pH measurement in the infant scalp. Am J Obstet Gynecol. 1976 Jan 15; 124(2):193-5. PMID: 2012.
    View in: PubMed
  66. Schmoldt A, Benthe HF, Haberland G. Digitoxin metabolism by rat liver microsomes. Biochem Pharmacol. 1975 Sep 1; 24(17):1639-41. PMID: 10.
    View in: PubMed
  67. Robinson JV, James AL. Some observations on the effects produced in white mice following the injection of certain suspensions of corroding bacilli. Br J Exp Pathol. 1975 Feb; 56(1):14-6. PMID: 1080; PMCID: PMC2072709.
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