Harvard Catalyst Profiles

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Caroline Elizabeth Shamu, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. P01CA139980 (MITCHISON, TIMOTHY J) Jun 1, 2010 - May 31, 2015
    NIH/NCI
    Mechanistic Pharmacology of Anti-Mitotics and Apoptosis Regulation
    Role: Co-Principal Investigator
  2. S10RR026582 (SHAMU, CAROLINE E) Mar 4, 2010 - Mar 3, 2011
    NIH/NCRR
    Laser scanning cytometer for high throughput screening
    Role: Principal Investigator
  3. U54AI057159 (KASPER, DENNIS L.) Sep 4, 2003 - Feb 29, 2008
    NIH/NIAID
    New England Regional Center of Excellence in Biodefense and Emerging Infectious D
    Role: Co-Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Keenan AB, Jenkins SL, Jagodnik KM, Koplev S, He E, Torre D, Wang Z, Dohlman AB, Silverstein MC, Lachmann A, Kuleshov MV, Ma'ayan A, Stathias V, Terryn R, Cooper D, Forlin M, Koleti A, Vidovic D, Chung C, Schürer SC, Vasiliauskas J, Pilarczyk M, Shamsaei B, Fazel M, Ren Y, Niu W, Clark NA, White S, Mahi N, Zhang L, Kouril M, Reichard JF, Sivaganesan S, Medvedovic M, Meller J, Koch RJ, Birtwistle MR, Iyengar R, Sobie EA, Azeloglu EU, Kaye J, Osterloh J, Haston K, Kalra J, Finkbiener S, Li J, Milani P, Adam M, Escalante-Chong R, Sachs K, Lenail A, Ramamoorthy D, Fraenkel E, Daigle G, Hussain U, Coye A, Rothstein J, Sareen D, Ornelas L, Banuelos M, Mandefro B, Ho R, Svendsen CN, Lim RG, Stocksdale J, Casale MS, Thompson TG, Wu J, Thompson LM, Dardov V, Venkatraman V, Matlock A, Van Eyk JE, Jaffe JD, Papanastasiou M, Subramanian A, Golub TR, Erickson SD, Fallahi-Sichani M, Hafner M, Gray NS, Lin JR, Mills CE, Muhlich JL, Niepel M, Shamu CE, Williams EH, Wrobel D, Sorger PK, Heiser LM, Gray JW, Korkola JE, Mills GB, LaBarge M, Feiler HS, Dane MA, Bucher E, Nederlof M, Sudar D, Gross S, Kilburn DF, Smith R, Devlin K, Margolis R, Derr L, Lee A, Pillai A. The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations. Cell Syst. 2018 01 24; 6(1):13-24. PMID: 29199020.
    Citations: 14     Fields:    
  2. Mohr SE, Smith JA, Shamu CE, Neumüller RA, Perrimon N. RNAi screening comes of age: improved techniques and complementary approaches. Nat Rev Mol Cell Biol. 2014 Sep; 15(9):591-600. PMID: 25145850.
    Citations: 86     Fields:    Translation:HumansAnimalsCells
  3. Yilmazel B, Hu Y, Sigoillot F, Smith JA, Shamu CE, Perrimon N, Mohr SE. Online GESS: prediction of miRNA-like off-target effects in large-scale RNAi screen data by seed region analysis. BMC Bioinformatics. 2014 Jun 17; 15:192. PMID: 24934636.
    Citations: 15     Fields:    Translation:Animals
  4. Vempati UD, Chung C, Mader C, Koleti A, Datar N, Vidovic D, Wrobel D, Erickson S, Muhlich JL, Berriz G, Benes CH, Subramanian A, Pillai A, Shamu CE, Schürer SC. Metadata Standard and Data Exchange Specifications to Describe, Model, and Integrate Complex and Diverse High-Throughput Screening Data from the Library of Integrated Network-based Cellular Signatures (LINCS). J Biomol Screen. 2014 Jun; 19(5):803-16. PMID: 24518066.
    Citations: 25     Fields:    Translation:HumansCells
  5. Tang Y, Xie T, Florian S, Moerke N, Shamu C, Benes C, Mitchison TJ. Differential determinants of cancer cell insensitivity to antimitotic drugs discriminated by a one-step cell imaging assay. J Biomol Screen. 2013 Oct; 18(9):1062-71. PMID: 23788527.
    Citations: 2     Fields:    Translation:HumansCells
  6. Shamu CE, Wiemann S, Boutros M. On target: a public repository for large-scale RNAi experiments. Nat Cell Biol. 2012 Feb 02; 14(2):115. PMID: 22298037.
    Citations: 5     Fields:    Translation:HumansAnimals
  7. Sansone SA, Rocca-Serra P, Field D, Maguire E, Taylor C, Hofmann O, Fang H, Neumann S, Tong W, Amaral-Zettler L, Begley K, Booth T, Bougueleret L, Burns G, Chapman B, Clark T, Coleman LA, Copeland J, Das S, de Daruvar A, de Matos P, Dix I, Edmunds S, Evelo CT, Forster MJ, Gaudet P, Gilbert J, Goble C, Griffin JL, Jacob D, Kleinjans J, Harland L, Haug K, Hermjakob H, Ho Sui SJ, Laederach A, Liang S, Marshall S, McGrath A, Merrill E, Reilly D, Roux M, Shamu CE, Shang CA, Steinbeck C, Trefethen A, Williams-Jones B, Wolstencroft K, Xenarios I, Hide W. Toward interoperable bioscience data. Nat Genet. 2012 Jan 27; 44(2):121-6. PMID: 22281772.
    Citations: 88     Fields:    
  8. Harris ES, Erickson SD, Tolopko AN, Cao S, Craycroft JA, Scholten R, Fu Y, Wang W, Liu Y, Zhao Z, Clardy J, Shamu CE, Eisenberg DM. Traditional Medicine Collection Tracking System (TM-CTS): a database for ethnobotanically driven drug-discovery programs. J Ethnopharmacol. 2011 May 17; 135(2):590-3. PMID: 21420479.
    Citations: 4     Fields:    
  9. Eisenberg DM, Harris ES, Littlefield BA, Cao S, Craycroft JA, Scholten R, Bayliss P, Fu Y, Wang W, Qiao Y, Zhao Z, Chen H, Liu Y, Kaptchuk T, Hahn WC, Wang X, Roberts T, Shamu CE, Clardy J. Developing a library of authenticated Traditional Chinese Medicinal (TCM) plants for systematic biological evaluation--rationale, methods and preliminary results from a Sino-American collaboration. Fitoterapia. 2011 Jan; 82(1):17-33. PMID: 21108995.
    Citations: 16     Fields:    Translation:HumansAnimals
  10. Tolopko AN, Sullivan JP, Erickson SD, Wrobel D, Chiang SL, Rudnicki K, Rudnicki S, Nale J, Selfors LM, Greenhouse D, Muhlich JL, Shamu CE. Screensaver: an open source lab information management system (LIMS) for high throughput screening facilities. BMC Bioinformatics. 2010 May 18; 11:260. PMID: 20482787.
    Citations: 15     Fields:    
  11. Hoffman GR, Moerke NJ, Hsia M, Shamu CE, Blenis J. A high-throughput, cell-based screening method for siRNA and small molecule inhibitors of mTORC1 signaling using the In Cell Western technique. Assay Drug Dev Technol. 2010 Apr; 8(2):186-99. PMID: 20085456.
    Citations: 9     Fields:    Translation:HumansCells
  12. Tsui M, Xie T, Orth JD, Carpenter AE, Rudnicki S, Kim S, Shamu CE, Mitchison TJ. An intermittent live cell imaging screen for siRNA enhancers and suppressors of a kinesin-5 inhibitor. PLoS One. 2009 Oct 05; 4(10):e7339. PMID: 19802393.
    Citations: 8     Fields:    Translation:HumansCells
  13. Birmingham A, Selfors LM, Forster T, Wrobel D, Kennedy CJ, Shanks E, Santoyo-Lopez J, Dunican DJ, Long A, Kelleher D, Smith Q, Beijersbergen RL, Ghazal P, Shamu CE. Statistical methods for analysis of high-throughput RNA interference screens. Nat Methods. 2009 Aug; 6(8):569-75. PMID: 19644458.
    Citations: 195     Fields:    Translation:Animals
  14. Inglese J, Shamu CE, Guy RK. Reporting data from high-throughput screening of small-molecule libraries. Nat Chem Biol. 2007 Aug; 3(8):438-41. PMID: 17637769.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  15. Parker CN, Shamu CE, Kraybill B, Austin CP, Bajorath J. Measure, mine, model, and manipulate: the future for HTS and chemoinformatics? Drug Discov Today. 2006 Oct; 11(19-20):863-5. PMID: 16997135.
    Citations:    Fields:    
  16. Shamu CE, Flierman D, Ploegh HL, Rapoport TA, Chau V. Polyubiquitination is required for US11-dependent movement of MHC class I heavy chain from endoplasmic reticulum into cytosol. Mol Biol Cell. 2001 Aug; 12(8):2546-55. PMID: 11514634.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  17. Casagrande R, Stern P, Diehn M, Shamu C, Osario M, Zúñiga M, Brown PO, Ploegh H. Degradation of proteins from the ER of S. cerevisiae requires an intact unfolded protein response pathway. Mol Cell. 2000 Apr; 5(4):729-35. PMID: 10882108.
    Citations: 62     Fields:    Translation:AnimalsCells
  18. Shamu CE, Story CM, Rapoport TA, Ploegh HL. The pathway of US11-dependent degradation of MHC class I heavy chains involves a ubiquitin-conjugated intermediate. J Cell Biol. 1999 Oct 04; 147(1):45-58. PMID: 10508854.
    Citations: 42     Fields:    Translation:HumansCells
  19. Raymond CS, Shamu CE, Shen MM, Seifert KJ, Hirsch B, Hodgkin J, Zarkower D. Evidence for evolutionary conservation of sex-determining genes. Nature. 1998 Feb 12; 391(6668):691-5. PMID: 9490411.
    Citations: 138     Fields:    Translation:HumansAnimalsCells
  20. Shamu CE. Splicing: HACking into the unfolded-protein response. Curr Biol. 1998 Feb 12; 8(4):R121-3. PMID: 9501974.
    Citations: 5     Fields:    Translation:AnimalsCells
  21. Shamu CE. Splicing together the unfolded-protein response. Curr Biol. 1997 Feb 01; 7(2):R67-70. PMID: 9081665.
    Citations: 10     Fields:    Translation:AnimalsCells
  22. Shamu CE, Walter P. Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus. EMBO J. 1996 Jun 17; 15(12):3028-39. PMID: 8670804.
    Citations: 175     Fields:    Translation:AnimalsCells
  23. Shamu CE, Cox JS, Walter P. The unfolded-protein-response pathway in yeast. Trends Cell Biol. 1994 Feb; 4(2):56-60. PMID: 14731868.
    Citations: 39     Fields:    
  24. Cox JS, Shamu CE, Walter P. Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase. Cell. 1993 Jun 18; 73(6):1197-206. PMID: 8513503.
    Citations: 388     Fields:    Translation:AnimalsCells
  25. Shamu CE, Murray AW. Sister chromatid separation in frog egg extracts requires DNA topoisomerase II activity during anaphase. J Cell Biol. 1992 Jun; 117(5):921-34. PMID: 1315785.
    Citations: 64     Fields:    Translation:AnimalsCells
  26. Miller DM, Shen MM, Shamu CE, Bürglin TR, Ruvkun G, Dubois ML, Ghee M, Wilson L. C. elegans unc-4 gene encodes a homeodomain protein that determines the pattern of synaptic input to specific motor neurons. Nature. 1992 Feb 27; 355(6363):841-5. PMID: 1347150.
    Citations: 34     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.