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Mason Wright Freeman, M.D.

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Overview

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R24RR020345 (FREEMAN, MASON W) Aug 26, 2009 - May 31, 2012
    NIH/NCRR
    Analysis of ABCA Transporter Function in Homologous Recombinant Mice
    Role: Principal Investigator
  2. R01HL072358 (SEED, BRIAN) Sep 30, 2002 - Jul 31, 2007
    NIH/NHLBI
    Shared Microarray Facility
    Role: Co-Principal Investigator
  3. R01HL068988 (FREEMAN, MASON W) Feb 1, 2002 - Jan 31, 2008
    NIH/NHLBI
    Cell Biology of ABCA1
    Role: Principal Investigator
  4. R24RR014466 (MOORE, KATHRYN J) Feb 15, 2001 - Jan 31, 2006
    NIH/NCRR
    DEVELOPMENT AND CHARACTERIZATION OF CD14 DEFICIENT MICE
    Role: Co-Principal Investigator
  5. U01HL066678 (FREEMAN, MASON W) Sep 30, 2000 - Jul 31, 2005
    NIH/NHLBI
    GENOMIC ANALYSIS OF STRESS AND INFLAMMATION
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Halvorsen YD, Walford G, Thurber T, Russell H, Massaro M, Freeman MW. A 12-week, randomized, double-blind, placebo-controlled, four-arm dose-finding phase 2 study evaluating bexagliflozin as monotherapy for adults with type 2 diabetes. Diabetes Obes Metab. 2020 04; 22(4):566-573. PMID: 31749238.
    Citations:    Fields:    
  2. Freeman MW, Guidon AC, Arvikar SL. Case 22-2019: A 65-Year-Old Woman with Myopathy. Reply. N Engl J Med. 2019 10 24; 381(17):1694. PMID: 31644864.
    Citations:    Fields:    Translation:Humans
  3. Halvorsen YC, Walford GA, Massaro J, Aftring RP, Freeman MW. A 96-week, multinational, randomized, double-blind, parallel-group, clinical trial evaluating the safety and effectiveness of bexagliflozin as a monotherapy for adults with type 2 diabetes. Diabetes Obes Metab. 2019 11; 21(11):2496-2504. PMID: 31297965.
    Citations:    Fields:    Translation:Humans
  4. Freeman MW, Singh AK, Guidon AC, Arvikar SL, Goldstein RH, Clement NF. Case 22-2019: A 65-Year-Old Woman with Weakness, Dark Urine, and Dysphagia. N Engl J Med. 2019 Jul 18; 381(3):275-283. PMID: 31314973.
    Citations:    Fields:    Translation:Humans
  5. Halvorsen YD, Lock JP, Zhou W, Zhu F, Freeman MW. A 24-week, randomized, double-blind, active-controlled clinical trial comparing bexagliflozin with sitagliptin as an adjunct to metformin for the treatment of type 2 diabetes in adults. Diabetes Obes Metab. 2019 10; 21(10):2248-2256. PMID: 31161692.
    Citations:    Fields:    Translation:Humans
  6. Allegretti AS, Zhang W, Zhou W, Thurber TK, Rigby SP, Bowman-Stroud C, Trescoli C, Serusclat P, Freeman MW, Halvorsen YC. Safety and Effectiveness of Bexagliflozin in Patients With Type 2 Diabetes Mellitus and Stage 3a/3b CKD. Am J Kidney Dis. 2019 09; 74(3):328-337. PMID: 31101403.
    Citations:    Fields:    Translation:HumansCTClinical Trials
  7. Antman EM, Di Corleto PE, Freeman MW, Ganz T, Golan DE, Kitterman R, Loscalzo J, Low M, McKenna E, O'Connor AC, Palazzolo M, Parrish J, Reizes O, Ross RS, Vaughan C, Vince DG, Watts L. NIH Centers for Accelerated Innovations Program: principles, practices, successes and challenges. Nat Rev Drug Discov. 2017 10; 16(10):663-664. PMID: 28775338.
    Citations:    Fields:    
  8. Levin JM, Holtzman SH, Maraganore J, Hastings PJ, Cohen R, Dahiyat B, Adams J, Adams C, Ahrens B, Albers J, Aspinall MG, Audia JE, Babler M, Barrett P, Barry Z, Bermingham N, Bloch S, Blum RI, Bolno PB, Bonney MW, Booth B, Bradbury DM, Brauer SK, Byers B, Cagnoni PJ, Cali BM, Ciechanover I, Clark C, Clayman MD, Cleland JL, Cobb P, Cooper R, Currie MG, Diekman J, Dobmeier EL, Doerfler D, Donley EL, Dunsire D, During M, Eckstein JW, Elenko E, Exter NA, Fleming JJ, Flesher GJ, Formela JF, Forrester R, Francois C, Franklin H, Freeman MW, Furst H, Gage LP, Galakatos N, Gallagher BM, Geraghty JA, Gill S, Goeddel DV, Goldsmith MA, Gowen M, Goyal V, Graney T, Grayzel D, Greene B, Grint P, Gutierrez-Ramos JC, Haney B, Ha-Ngoc T, Harris T, Hasnain F, Hata YS, Hecht P, Henshaw L, Heyman R, Hoppenot H, Horvitz HR, Hughes TE, Hutton WS, Isaacs ST, Jenkins A, Jonker J, Kaplan J, Karsen P, Keiper J, Kim J, Kindler J, King R, King V, Kjellson N, Koenig S, Koenig G, Kolchinsky P, Laikind P, Langer RB, Lee JJ, Leff JS, Leicher BA, Leschly N, Levin A, Levin M, Levine AJ, Levy A, Liu DR, Lodish HF, Lopatin U, Love TW, Macdonald G, Maderis GJ, Mahadevia A, Mahanthappa NK, Martin JF, Martin A, Martucci WE, McArthur JG, McCann CM, McCarthy SA, McDonough CG, Mendlein J, Miller L, Miralles D, Moch KI, More B, Myers AG, Narachi MA, Nashat A, Nelson W, Newell WJ, Olle B, Osborn JE, Owens JC, Pande A, Papadopoulos S, Parker HS, Parmar KM, Patterson MR, Paul SM, Perez R, Perry M, Pfeffer CG, Powell M, Pruzanski M, Purcell DJ, Rakhit A, Ramamoorthi K, Rastetter W, Rawcliffe AA, Reid LE, Renaud RC, Rhodes JP, Rieflin WJ, Robins C, Rocklage SM, Rosenblatt M, Rosin JG, Rutter WJ, Saha S, Samuels C, Sato VL, Scangos G, Scarlett JA, Schenkein D, Schreiber SL, Schwab A, Sekhri P, Shah R, Shenk T, Siegall CB, Simon NJ, Simonian N, Stein J, Su M, Szela MT, Taglietti M, Tandon N, Termeer H, Thornberry NA, Tolar M, Ulevitch R, Vaishnaw AK, VanLent A, Varsavsky M, Vlasuk GP, Vounatsos M, Waksal SG, Warma N, Watts RJ, Werber Y, Westphal C, Wierenga W, Williams DE, Williams LR, Xanthopoulos KG, Zohar D, Zweifach SS. US immigration order strikes against biotech. Nat Biotechnol. 2017 03 07; 35(3):204-206. PMID: 28267733.
    Citations: 2     Fields:    Translation:Humans
  9. Bakris GL, Pitt B, Weir MR, Freeman MW, Mayo MR, Garza D, Stasiv Y, Zawadzki R, Berman L, Bushinsky DA. Effect of Patiromer on Serum Potassium Level in Patients With Hyperkalemia and Diabetic Kidney Disease: The AMETHYST-DN Randomized Clinical Trial. JAMA. 2015 Jul 14; 314(2):151-61. PMID: 26172895.
    Citations: 69     Fields:    Translation:HumansCTClinical Trials
  10. Fox CS, Hall JL, Arnett DK, Ashley EA, Delles C, Engler MB, Freeman MW, Johnson JA, Lanfear DE, Liggett SB, Lusis AJ, Loscalzo J, MacRae CA, Musunuru K, Newby LK, O'Donnell CJ, Rich SS, Terzic A. Future translational applications from the contemporary genomics era: a scientific statement from the American Heart Association. Circulation. 2015 May 12; 131(19):1715-36. PMID: 25882488.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  11. Stitziel NO, Peloso GM, Abifadel M, Cefalu AB, Fouchier S, Motazacker MM, Tada H, Larach DB, Awan Z, Haller JF, Pullinger CR, Varret M, Rabès JP, Noto D, Tarugi P, Kawashiri MA, Nohara A, Yamagishi M, Risman M, Deo R, Ruel I, Shendure J, Nickerson DA, Wilson JG, Rich SS, Gupta N, Farlow DN, Neale BM, Daly MJ, Kane JP, Freeman MW, Genest J, Rader DJ, Mabuchi H, Kastelein JJ, Hovingh GK, Averna MR, Gabriel S, Boileau C, Kathiresan S. Exome sequencing in suspected monogenic dyslipidemias. Circ Cardiovasc Genet. 2015 Apr; 8(2):343-50. PMID: 25632026.
    Citations: 11     Fields:    Translation:Humans
  12. Lo J, Rosenberg ES, Fitzgerald ML, Bazner SB, Ihenachor EJ, Hawxhurst V, Borkowska AH, Wei J, Zimmerman CO, Burdo TH, Williams KC, Freeman MW, Grinspoon SK. High-density lipoprotein-mediated cholesterol efflux capacity is improved by treatment with antiretroviral therapy in acute human immunodeficiency virus infection. Open Forum Infect Dis. 2014 Dec; 1(3):ofu108. PMID: 25734176.
    Citations: 12     
  13. Haller JF, Cavallaro P, Hernandez NJ, Dolat L, Soscia SJ, Welti R, Grabowski GA, Fitzgerald ML, Freeman MW. Endogenous ß-glucocerebrosidase activity in Abca12?/?epidermis elevates ceramide levels after topical lipid application but does not restore barrier function. J Lipid Res. 2014 Mar; 55(3):493-503. PMID: 24293640.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  14. Best SR, Friedman AD, Landau-Zemer T, Barbu AM, Burns JA, Freeman MW, Halvorsen YD, Hillman RE, Zeitels SM. Safety and dosing of bevacizumab (avastin) for the treatment of recurrent respiratory papillomatosis. Ann Otol Rhinol Laryngol. 2012 Sep; 121(9):587-93. PMID: 23012897.
    Citations: 8     Fields:    Translation:Humans
  15. Perlstein TS, Goldhaber SZ, Nelson K, Joshi V, Morgan TV, Lesko LJ, Lee JY, Gobburu J, Schoenfeld D, Kucherlapati R, Freeman MW, Creager MA. The Creating an Optimal Warfarin Nomogram (CROWN) Study. Thromb Haemost. 2012 Jan; 107(1):59-68. PMID: 22116191.
    Citations: 4     Fields:    Translation:HumansCTClinical Trials
  16. Zeitels SM, Barbu AM, Landau-Zemer T, Lopez-Guerra G, Burns JA, Friedman AD, Freeman MW, Halvorsen YD, Hillman RE. Local injection of bevacizumab (Avastin) and angiolytic KTP laser treatment of recurrent respiratory papillomatosis of the vocal folds: a prospective study. Ann Otol Rhinol Laryngol. 2011 Oct; 120(10):627-34. PMID: 22097147.
    Citations: 11     Fields:    Translation:HumansCTClinical Trials
  17. Freeman MW, Dervan AP. The path from bench to bedside: considerations before starting the journey. J Investig Med. 2011 Jun; 59(5):746-51. PMID: 21441830.
    Citations: 2     Fields:    Translation:Humans
  18. Kim WS, Hill AF, Fitzgerald ML, Freeman MW, Evin G, Garner B. Wild type and Tangier disease ABCA1 mutants modulate cellular amyloid-ß production independent of cholesterol efflux activity. J Alzheimers Dis. 2011; 27(2):441-52. PMID: 21860089.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  19. Zuo Y, Zhuang DZ, Han R, Isaac G, Tobin JJ, McKee M, Welti R, Brissette JL, Fitzgerald ML, Freeman MW. ABCA12 maintains the epidermal lipid permeability barrier by facilitating formation of ceramide linoleic esters. J Biol Chem. 2008 Dec 26; 283(52):36624-35. PMID: 18957418.
    Citations: 31     Fields:    Translation:Animals
  20. Manning-Tobin JJ, Moore KJ, Seimon TA, Bell SA, Sharuk M, Alvarez-Leite JI, de Winther MP, Tabas I, Freeman MW. Loss of SR-A and CD36 activity reduces atherosclerotic lesion complexity without abrogating foam cell formation in hyperlipidemic mice. Arterioscler Thromb Vasc Biol. 2009 Jan; 29(1):19-26. PMID: 18948635.
    Citations: 94     Fields:    Translation:AnimalsCells
  21. Tamehiro N, Zhou S, Okuhira K, Benita Y, Brown CE, Zhuang DZ, Latz E, Hornemann T, von Eckardstein A, Xavier RJ, Freeman MW, Fitzgerald ML. SPTLC1 binds ABCA1 to negatively regulate trafficking and cholesterol efflux activity of the transporter. Biochemistry. 2008 Jun 10; 47(23):6138-47. PMID: 18484747.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  22. Moore KJ, Freeman MW. Targeting Innate Immunity for CV Benefit. Drug Discov Today Ther Strateg. 2008; 5(1):15-23. PMID: 19430537.
    Citations: 1     
  23. Kiss RS, Kavaslar N, Okuhira K, Freeman MW, Walter S, Milne RW, McPherson R, Marcel YL. Genetic etiology of isolated low HDL syndrome: incidence and heterogeneity of efflux defects. Arterioscler Thromb Vasc Biol. 2007 May; 27(5):1139-45. PMID: 17303779.
    Citations: 17     Fields:    Translation:Humans
  24. Fitzgerald ML, Xavier R, Haley KJ, Welti R, Goss JL, Brown CE, Zhuang DZ, Bell SA, Lu N, McKee M, Seed B, Freeman MW. ABCA3 inactivation in mice causes respiratory failure, loss of pulmonary surfactant, and depletion of lung phosphatidylglycerol. J Lipid Res. 2007 Mar; 48(3):621-32. PMID: 17142808.
    Citations: 52     Fields:    Translation:Animals
  25. DeFaria Yeh D, Freeman MW, Meigs JB, Grant RW. Risk factors for coronary artery disease in patients with elevated high-density lipoprotein cholesterol. Am J Cardiol. 2007 Jan 01; 99(1):1-4. PMID: 17196452.
    Citations: 10     Fields:    Translation:Humans
  26. Kuo WP, Liu F, Trimarchi J, Punzo C, Lombardi M, Sarang J, Whipple ME, Maysuria M, Serikawa K, Lee SY, McCrann D, Kang J, Shearstone JR, Burke J, Park DJ, Wang X, Rector TL, Ricciardi-Castagnoli P, Perrin S, Choi S, Bumgarner R, Kim JH, Short GF, Freeman MW, Seed B, Jensen R, Church GM, Hovig E, Cepko CL, Park P, Ohno-Machado L, Jenssen TK. A sequence-oriented comparison of gene expression measurements across different hybridization-based technologies. Nat Biotechnol. 2006 Jul; 24(7):832-40. PMID: 16823376.
    Citations: 63     Fields:    
  27. Moore KJ, Freeman MW. Scavenger receptors in atherosclerosis: beyond lipid uptake. Arterioscler Thromb Vasc Biol. 2006 Aug; 26(8):1702-11. PMID: 16728653.
    Citations: 133     Fields:    Translation:HumansAnimals
  28. Freeman MW. Statins, cholesterol, and the prevention of coronary heart disease. FASEB J. 2006 Feb; 20(2):200-1. PMID: 16449790.
    Citations: 4     Fields:    Translation:Humans
  29. Okuhira K, Fitzgerald ML, Sarracino DA, Manning JJ, Bell SA, Goss JL, Freeman MW. Purification of ATP-binding cassette transporter A1 and associated binding proteins reveals the importance of beta1-syntrophin in cholesterol efflux. J Biol Chem. 2005 Nov 25; 280(47):39653-64. PMID: 16192269.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  30. Moore KJ, Kunjathoor VV, Koehn SL, Manning JJ, Tseng AA, Silver JM, McKee M, Freeman MW. Loss of receptor-mediated lipid uptake via scavenger receptor A or CD36 pathways does not ameliorate atherosclerosis in hyperlipidemic mice. J Clin Invest. 2005 Aug; 115(8):2192-201. PMID: 16075060.
    Citations: 135     Fields:    Translation:AnimalsCells
  31. Heller EA, Liu E, Tager AM, Sinha S, Roberts JD, Koehn SL, Libby P, Aikawa ER, Chen JQ, Huang P, Freeman MW, Moore KJ, Luster AD, Gerszten RE. Inhibition of atherogenesis in BLT1-deficient mice reveals a role for LTB4 and BLT1 in smooth muscle cell recruitment. Circulation. 2005 Jul 26; 112(4):578-86. PMID: 16043658.
    Citations: 39     Fields:    Translation:AnimalsCells
  32. Groves RL, Chen J, Civerolo EL, Freeman MW, Viveros MA. Spatial Analysis of Almond Leaf Scorch Disease in the San Joaquin Valley of California: Factors Affecting Pathogen Distribution and Spread. Plant Dis. 2005 Jun; 89(6):581-589. PMID: 30795382.
    Citations:    Fields:    
  33. Farnier M, Freeman MW, Macdonell G, Perevozskaya I, Davies MJ, Mitchel YB, Gumbiner B. Efficacy and safety of the coadministration of ezetimibe with fenofibrate in patients with mixed hyperlipidaemia. Eur Heart J. 2005 May; 26(9):897-905. PMID: 15781429.
    Citations: 26     Fields:    Translation:HumansCTClinical Trials
  34. Jeyaseelan S, Chu HW, Young SK, Freeman MW, Worthen GS. Distinct roles of pattern recognition receptors CD14 and Toll-like receptor 4 in acute lung injury. Infect Immun. 2005 Mar; 73(3):1754-63. PMID: 15731076.
    Citations: 43     Fields:    Translation:AnimalsCells
  35. Lee ML, Gray RJ, Björkbacka H, Freeman MW. Generalized rank tests for replicated microarray data. Stat Appl Genet Mol Biol. 2005; 4:Article3. PMID: 16646848.
    Citations: 2     Fields:    
  36. Lee ML, Whitmore GA, Björkbacka H, Freeman MW. Nonparametric methods for microarray data based on exchangeability and borrowed power. J Biopharm Stat. 2005; 15(5):783-97. PMID: 16078385.
    Citations: 3     Fields:    Translation:AnimalsCells
  37. Laberge MA, Moore KJ, Freeman MW. Atherosclerosis and innate immune signaling. Ann Med. 2005; 37(2):130-40. PMID: 16026120.
    Citations: 11     Fields:    Translation:HumansCells
  38. Ricci R, Sumara G, Sumara I, Rozenberg I, Kurrer M, Akhmedov A, Hersberger M, Eriksson U, Eberli FR, Becher B, Borén J, Chen M, Cybulsky MI, Moore KJ, Freeman MW, Wagner EF, Matter CM, Lüscher TF. Requirement of JNK2 for scavenger receptor A-mediated foam cell formation in atherogenesis. Science. 2004 Nov 26; 306(5701):1558-61. PMID: 15567863.
    Citations: 99     Fields:    Translation:AnimalsCells
  39. Kim WS, Fitzgerald ML, Kang K, Okuhira K, Bell SA, Manning JJ, Koehn SL, Lu N, Moore KJ, Freeman MW. Abca7 null mice retain normal macrophage phosphatidylcholine and cholesterol efflux activity despite alterations in adipose mass and serum cholesterol levels. J Biol Chem. 2005 Feb 04; 280(5):3989-95. PMID: 15550377.
    Citations: 41     Fields:    Translation:AnimalsCells
  40. Björkbacka H, Fitzgerald KA, Huet F, Li X, Gregory JA, Lee MA, Ordija CM, Dowley NE, Golenbock DT, Freeman MW. The induction of macrophage gene expression by LPS predominantly utilizes Myd88-independent signaling cascades. Physiol Genomics. 2004 Nov 17; 19(3):319-30. PMID: 15367722.
    Citations: 71     Fields:    Translation:HumansAnimalsCells
  41. Fitzgerald ML, Okuhira K, Short GF, Manning JJ, Bell SA, Freeman MW. ATP-binding cassette transporter A1 contains a novel C-terminal VFVNFA motif that is required for its cholesterol efflux and ApoA-I binding activities. J Biol Chem. 2004 Nov 12; 279(46):48477-85. PMID: 15347662.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  42. Björkbacka H, Kunjathoor VV, Moore KJ, Koehn S, Ordija CM, Lee MA, Means T, Halmen K, Luster AD, Golenbock DT, Freeman MW. Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways. Nat Med. 2004 Apr; 10(4):416-21. PMID: 15034566.
    Citations: 184     Fields:    Translation:AnimalsCells
  43. Chroni A, Liu T, Fitzgerald ML, Freeman MW, Zannis VI. Cross-linking and lipid efflux properties of apoA-I mutants suggest direct association between apoA-I helices and ABCA1. Biochemistry. 2004 Feb 24; 43(7):2126-39. PMID: 14967052.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  44. Fitzgerald ML, Morris AL, Chroni A, Mendez AJ, Zannis VI, Freeman MW. ABCA1 and amphipathic apolipoproteins form high-affinity molecular complexes required for cholesterol efflux. J Lipid Res. 2004 Feb; 45(2):287-94. PMID: 14617740.
    Citations: 36     Fields:    Translation:HumansCells
  45. Kim WS, Ordija CM, Freeman MW. Activation of signaling pathways by putative scavenger receptor class A (SR-A) ligands requires CD14 but not SR-A. Biochem Biophys Res Commun. 2003 Oct 17; 310(2):542-9. PMID: 14521944.
    Citations: 16     Fields:    Translation:AnimalsCells
  46. El Khoury JB, Moore KJ, Means TK, Leung J, Terada K, Toft M, Freeman MW, Luster AD. CD36 mediates the innate host response to beta-amyloid. J Exp Med. 2003 Jun 16; 197(12):1657-66. PMID: 12796468.
    Citations: 145     Fields:    Translation:HumansAnimalsCells
  47. Freeman MW, Moore KJ. eLiXiRs for restraining inflammation. Nat Med. 2003 Feb; 9(2):168-9. PMID: 12563335.
    Citations: 3     Fields:    Translation:Animals
  48. Yang KK, Dorner BG, Merkel U, Ryffel B, Schütt C, Golenbock D, Freeman MW, Jack RS. Neutrophil influx in response to a peritoneal infection with Salmonella is delayed in lipopolysaccharide-binding protein or CD14-deficient mice. J Immunol. 2002 Oct 15; 169(8):4475-80. PMID: 12370383.
    Citations: 26     Fields:    Translation:AnimalsCells
  49. Kunjathoor VV, Febbraio M, Podrez EA, Moore KJ, Andersson L, Koehn S, Rhee JS, Silverstein R, Hoff HF, Freeman MW. Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages. J Biol Chem. 2002 Dec 20; 277(51):49982-8. PMID: 12376530.
    Citations: 252     Fields:    Translation:AnimalsCells
  50. Henneke P, Takeuchi O, Malley R, Lien E, Ingalls RR, Freeman MW, Mayadas T, Nizet V, Akira S, Kasper DL, Golenbock DT. Cellular activation, phagocytosis, and bactericidal activity against group B streptococcus involve parallel myeloid differentiation factor 88-dependent and independent signaling pathways. J Immunol. 2002 Oct 01; 169(7):3970-7. PMID: 12244198.
    Citations: 58     Fields:    Translation:HumansAnimalsCells
  51. Moore KJ, El Khoury J, Medeiros LA, Terada K, Geula C, Luster AD, Freeman MW. A CD36-initiated signaling cascade mediates inflammatory effects of beta-amyloid. J Biol Chem. 2002 Dec 06; 277(49):47373-9. PMID: 12239221.
    Citations: 119     Fields:    Translation:AnimalsCells
  52. Fitzgerald ML, Morris AL, Rhee JS, Andersson LP, Mendez AJ, Freeman MW. Naturally occurring mutations in the largest extracellular loops of ABCA1 can disrupt its direct interaction with apolipoprotein A-I. J Biol Chem. 2002 Sep 06; 277(36):33178-87. PMID: 12084722.
    Citations: 48     Fields:    Translation:HumansCells
  53. Fitzgerald ML, Moore KJ, Freeman MW. Nuclear hormone receptors and cholesterol trafficking: the orphans find a new home. J Mol Med (Berl). 2002 May; 80(5):271-81. PMID: 12021839.
    Citations: 13     Fields:    Translation:HumansAnimals
  54. Rosen ED, Hsu CH, Wang X, Sakai S, Freeman MW, Gonzalez FJ, Spiegelman BM. C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway. Genes Dev. 2002 Jan 01; 16(1):22-6. PMID: 11782441.
    Citations: 354     Fields:    Translation:AnimalsCells
  55. Moore KJ, Fitzgerald ML, Freeman MW. Peroxisome proliferator-activated receptors in macrophage biology: friend or foe? Curr Opin Lipidol. 2001 Oct; 12(5):519-27. PMID: 11561171.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  56. Bobryshev YV, Taksir T, Lord RS, Freeman MW. Evidence that dendritic cells infiltrate atherosclerotic lesions in apolipoprotein E-deficient mice. Histol Histopathol. 2001 07; 16(3):801-8. PMID: 11510970.
    Citations: 13     Fields:    Translation:AnimalsCells
  57. Fitzgerald ML, Mendez AJ, Moore KJ, Andersson LP, Panjeton HA, Freeman MW. ATP-binding cassette transporter A1 contains an NH2-terminal signal anchor sequence that translocates the protein's first hydrophilic domain to the exoplasmic space. J Biol Chem. 2001 May 04; 276(18):15137-45. PMID: 11328826.
    Citations: 24     Fields:    Translation:Cells
  58. Rigotti A, Freeman MW. Manipulating intestinal cholesterol absorption and hepatic cholesterol and bile acid metabolism by activation of deorphanized nuclear receptors. Gastroenterology. 2001 Mar; 120(4):1054-5. PMID: 11231965.
    Citations:    Fields:    Translation:Animals
  59. Moore KJ, Rosen ED, Fitzgerald ML, Randow F, Andersson LP, Altshuler D, Milstone DS, Mortensen RM, Spiegelman BM, Freeman MW. The role of PPAR-gamma in macrophage differentiation and cholesterol uptake. Nat Med. 2001 Jan; 7(1):41-7. PMID: 11135614.
    Citations: 111     Fields:    Translation:AnimalsCells
  60. Li Z, Kako Y, Pang L, Freeman MW, Glick JM, Wang X, Goldberg IJ. Effects of overexpression of the amino-terminal fragment of apolipoprotein B on apolipoprotein B and lipoprotein production. J Lipid Res. 2000 Dec; 41(12):1912-20. PMID: 11108724.
    Citations:    Fields:    Translation:AnimalsCells
  61. Wang X, Zeng W, Murakawa M, Freeman MW, Seed B. Episomal segregation of the adenovirus enhancer sequence by conditional genome rearrangement abrogates late viral gene expression. J Virol. 2000 Dec; 74(23):11296-303. PMID: 11070029.
    Citations: 9     Fields:    Translation:HumansCells
  62. Kurt-Jones EA, Popova L, Kwinn L, Haynes LM, Jones LP, Tripp RA, Walsh EE, Freeman MW, Golenbock DT, Anderson LJ, Finberg RW. Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus. Nat Immunol. 2000 Nov; 1(5):398-401. PMID: 11062499.
    Citations: 458     Fields:    Translation:HumansAnimalsCells
  63. Moore KJ, Andersson LP, Ingalls RR, Monks BG, Li R, Arnaout MA, Golenbock DT, Freeman MW. Divergent response to LPS and bacteria in CD14-deficient murine macrophages. J Immunol. 2000 Oct 15; 165(8):4272-80. PMID: 11035061.
    Citations: 54     Fields:    Translation:AnimalsCells
  64. Brousseau ME, Eberhart GP, Dupuis J, Asztalos BF, Goldkamp AL, Schaefer EJ, Freeman MW. Cellular cholesterol efflux in heterozygotes for tangier disease is markedly reduced and correlates with high density lipoprotein cholesterol concentration and particle size. J Lipid Res. 2000 Jul; 41(7):1125-35. PMID: 10884295.
    Citations: 12     Fields:    Translation:HumansCells
  65. Fitzgerald ML, Moore KJ, Freeman MW, Reed GL. Lipopolysaccharide induces scavenger receptor A expression in mouse macrophages: a divergent response relative to human THP-1 monocyte/macrophages. J Immunol. 2000 Mar 01; 164(5):2692-700. PMID: 10679110.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  66. Brousseau ME, Schaefer EJ, Dupuis J, Eustace B, Van Eerdewegh P, Goldkamp AL, Thurston LM, FitzGerald MG, Yasek-McKenna D, O'Neill G, Eberhart GP, Weiffenbach B, Ordovas JM, Freeman MW, Brown RH, Gu JZ. Novel mutations in the gene encoding ATP-binding cassette 1 in four tangier disease kindreds. J Lipid Res. 2000 Mar; 41(3):433-41. PMID: 10706591.
    Citations: 15     Fields:    Translation:HumansCells
  67. Fabunmi RP, Moore KJ, Libby P, Freeman MW. Stromelysin-1 (MMP-3) expression driven by a macrophage-specific promoter results in reduced viability in transgenic mice. Atherosclerosis. 2000 Feb; 148(2):375-86. PMID: 10657574.
    Citations: 1     Fields:    Translation:AnimalsCells
  68. Freeman MW. Effluxed lipids: Tangier Island's latest export. Proc Natl Acad Sci U S A. 1999 Sep 28; 96(20):10950-2. PMID: 10500104.
    Citations: 1     Fields:    Translation:HumansAnimals
  69. Chiang N, Gronert K, Clish CB, O'Brien JA, Freeman MW, Serhan CN. Leukotriene B4 receptor transgenic mice reveal novel protective roles for lipoxins and aspirin-triggered lipoxins in reperfusion. J Clin Invest. 1999 Aug; 104(3):309-16. PMID: 10430612.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  70. Moore KJ, Freeman MW. Embryonal Stem (ES) Cell-Derived Macrophages : A Cellular System that Facilitates the Genetic Dissection of Macrophage Function. Methods Mol Med. 1999; 30:343-55. PMID: 21341038.
    Citations:    Fields:    
  71. Moore KJ, Fabunmi RP, Andersson LP, Freeman MW. In vitro-differentiated embryonic stem cell macrophages: a model system for studying atherosclerosis-associated macrophage functions. Arterioscler Thromb Vasc Biol. 1998 Oct; 18(10):1647-54. PMID: 9763539.
    Citations: 12     Fields:    Translation:Cells
  72. Andersson L, Freeman MW. Functional changes in scavenger receptor binding conformation are induced by charge mutants spanning the entire collagen domain. J Biol Chem. 1998 Jul 31; 273(31):19592-601. PMID: 9677385.
    Citations: 11     Fields:    Translation:AnimalsCells
  73. Eberhart GP, Mendez AJ, Freeman MW. Decreased cholesterol efflux from fibroblasts of a patient without Tangier disease, but with markedly reduced high density lipoprotein cholesterol levels. J Clin Endocrinol Metab. 1998 Mar; 83(3):836-46. PMID: 9506737.
    Citations: 4     Fields:    Translation:HumansCells
  74. Freeman MW. Scavenger receptors in atherosclerosis. Curr Opin Hematol. 1997 Jan; 4(1):41-7. PMID: 9050378.
    Citations: 7     Fields:    Translation:HumansAnimals
  75. Aftring RP, Freeman MW. Structure of the murine macrophage scavenger receptor gene and evaluation of sequences that regulate expression in the macrophage cell line, P388D. J Lipid Res. 1995 Jun; 36(6):1305-14. PMID: 7666008.
    Citations: 3     Fields:    Translation:AnimalsCells
  76. Li H, Freeman MW, Libby P. Regulation of smooth muscle cell scavenger receptor expression in vivo by atherogenic diets and in vitro by cytokines. J Clin Invest. 1995 Jan; 95(1):122-33. PMID: 7814605.
    Citations: 26     Fields:    Translation:AnimalsCells
  77. Aftring RP, Freeman MW. Of mice, men and cholesterol. Hepatology. 1994 Apr; 19(4):1054-6. PMID: 8138246.
    Citations:    Fields:    Translation:HumansAnimals
  78. Freeman MW. Macrophage scavenger receptors. Curr Opin Lipidol. 1994 Apr; 5(2):143-8. PMID: 8044417.
    Citations: 3     Fields:    Translation:HumansCells
  79. Golenbock DT, Liu Y, Millham FH, Freeman MW, Zoeller RA. Surface expression of human CD14 in Chinese hamster ovary fibroblasts imparts macrophage-like responsiveness to bacterial endotoxin. J Biol Chem. 1993 Oct 15; 268(29):22055-9. PMID: 7691822.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  80. Retsky KL, Freeman MW, Frei B. Ascorbic acid oxidation product(s) protect human low density lipoprotein against atherogenic modification. Anti- rather than prooxidant activity of vitamin C in the presence of transition metal ions. J Biol Chem. 1993 Jan 15; 268(2):1304-9. PMID: 8419332.
    Citations: 31     Fields:    Translation:HumansCells
  81. Bickel PE, Freeman MW. Rabbit aortic smooth muscle cells express inducible macrophage scavenger receptor messenger RNA that is absent from endothelial cells. J Clin Invest. 1992 Oct; 90(4):1450-7. PMID: 1401078.
    Citations: 12     Fields:    Translation:AnimalsCells
  82. Abou-Samra AB, Jüppner H, Force T, Freeman MW, Kong XF, Schipani E, Urena P, Richards J, Bonventre JV, Potts JT, et al. Expression cloning of a common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells: a single receptor stimulates intracellular accumulation of both cAMP and inositol trisphosphates and increases intracellular free calcium. Proc Natl Acad Sci U S A. 1992 Apr 01; 89(7):2732-6. PMID: 1313566.
    Citations: 153     Fields:    Translation:AnimalsCells
  83. Wiren KM, Ivashkiv L, Ma P, Freeman MW, Potts JT, Kronenberg HM. Mutations in signal sequence cleavage domain of preproparathyroid hormone alter protein translocation, signal sequence cleavage, and membrane-binding properties. Mol Endocrinol. 1989 Feb; 3(2):240-50. PMID: 2710131.
    Citations: 5     Fields:    Translation:AnimalsCells
  84. Freeman MW, Wiren KM, Rapoport A, Lazar M, Potts JT, Kronenberg HM. Consequences of amino-terminal deletions of preproparathyroid hormone signal sequence. Mol Endocrinol. 1987 Sep; 1(9):628-38. PMID: 3153480.
    Citations: 3     Fields:    Translation:HumansCells
  85. Freeman MW, Spring-Mills E, Jones AL. The effect of oxandrolone on low and high density lipoprotein profiles in retired breeder rats. J Gerontol. 1980 Jan; 35(1):31-8. PMID: 7350219.
    Citations:    Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.