Harvard Catalyst Profiles

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Osman Berk Usta, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL145031 (USTA, OSMAN BERK) Apr 1, 2020 - Mar 31, 2024
    NIH/NHLBI
    Deep Supercooling of Red Blood Cells: Towards Practical Long Term Storage
    Role: Principal Investigator
  2. R21GM136002 (USTA, OSMAN BERK) Sep 20, 2019 - Aug 31, 2021
    NIH/NIGMS
    Deep Supercooling of Liver Cells and 2D and 3D Tissue Constructs: Effect of Attachment
    Role: Principal Investigator
  3. R21AI142415 (USTA, OSMAN BERK) Nov 14, 2018 - Oct 31, 2020
    NIH/NIAID
    High Quality Long Term Preservation of Sporozoites via Deep Supercooling
    Role: Principal Investigator
  4. R21EB020192 (USTA, OSMAN BERK) Sep 3, 2015 - Jun 30, 2017
    NIH/NIBIB
    Novel Microfluidic Platforms for Actively Controlled in-vitro Liver Zonation
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Bulutoglu B, Rey-Bedón C, Mert S, Tian L, Jang YY, Yarmush ML, Usta OB. A comparison of hepato-cellular in vitro platforms to study CYP3A4 induction. PLoS One. 2020; 15(2):e0229106. PMID: 32106230.
    Citations:    
  2. Kang YBA, Eo J, Bulutoglu B, Yarmush ML, Usta OB. Progressive hypoxia-on-a-chip: An in vitro oxygen gradient model for capturing the effects of hypoxia on primary hepatocytes in health and disease. Biotechnol Bioeng. 2020 03; 117(3):763-775. PMID: 31736056.
    Citations:    
  3. Huang H, Rey-Bedón C, Yarmush ML, Usta OB. Deep-supercooling for extended preservation of adipose-derived stem cells. Cryobiology. 2020 02 01; 92:67-75. PMID: 31751557.
    Citations:    
  4. Bulutoglu B, Mert S, Rey-Bedón C, Deng SL, Yarmush ML, Usta OB. Rapid maturation of the hepatic cell line Huh7 via CDK inhibition for PXR dependent CYP450 metabolism and induction. Sci Rep. 2019 11 01; 9(1):15848. PMID: 31676845.
    Citations:    
  5. Bulutoglu B, Rey-Bedón C, Kang YBA, Mert S, Yarmush ML, Usta OB. A microfluidic patterned model of non-alcoholic fatty liver disease: applications to disease progression and zonation. Lab Chip. 2019 09 10; 19(18):3022-3031. PMID: 31465069.
    Citations:    
  6. Li L, Gokduman K, Gokaltun A, Yarmush ML, Usta OB. A microfluidic 3D hepatocyte chip for hepatotoxicity testing of nanoparticles. Nanomedicine (Lond). 2019 08; 14(16):2209-2226. PMID: 31179822.
    Citations:    
  7. Gökaltun A, Kang YBA, Yarmush ML, Usta OB, Asatekin A. Simple Surface Modification of Poly(dimethylsiloxane) via Surface Segregating Smart Polymers for Biomicrofluidics. Sci Rep. 2019 05 14; 9(1):7377. PMID: 31089162.
    Citations:    
  8. Rubin AE, Usta OB, Schloss R, Yarmush M, Golberg A. Selective Inactivation of Pseudomonas aeruginosa and Staphylococcus epidermidis with Pulsed Electric Fields and Antibiotics. Adv Wound Care (New Rochelle). 2019 Apr 01; 8(4):136-148. PMID: 31737412.
    Citations:    
  9. Rubin AE, Levkov K, Usta OB, Yarmush M, Golberg A. IGBT-Based Pulsed Electric Fields Generator for Disinfection: Design and In Vitro Studies on Pseudomonas aeruginosa. Ann Biomed Eng. 2019 May; 47(5):1314-1325. PMID: 30726513.
    Citations:    
  10. Huang H, Yarmush ML, Usta OB. Long-term deep-supercooling of large-volume water and red cell suspensions via surface sealing with immiscible liquids. Nat Commun. 2018 08 10; 9(1):3201. PMID: 30097570.
    Citations:    Fields:    Translation:HumansCells
  11. Kang YBA, Eo J, Mert S, Yarmush ML, Usta OB. Metabolic Patterning on a Chip: Towards in vitro Liver Zonation of Primary Rat and Human Hepatocytes. Sci Rep. 2018 06 12; 8(1):8951. PMID: 29895900.
    Citations: 1     Fields:    
  12. Gokduman K, Bestepe F, Li L, Yarmush ML, Usta OB. Dose-, treatment- and time-dependent toxicity of superparamagnetic iron oxide nanoparticles on primary rat hepatocytes. Nanomedicine (Lond). 2018 06; 13(11):1267-1284. PMID: 29949471.
    Citations:    Fields:    Translation:AnimalsCells
  13. Serpooshan V, Chen P, Wu H, Lee S, Sharma A, Hu DA, Venkatraman S, Ganesan AV, Usta OB, Yarmush M, Yang F, Wu JC, Demirci U, Wu SM. Bioacoustic-enabled patterning of human iPSC-derived cardiomyocytes into 3D cardiac tissue. Biomaterials. 2017 07; 131:47-57. PMID: 28376365.
    Citations: 1     Fields:    Translation:HumansCells
  14. Gokaltun A, Yarmush ML, Asatekin A, Usta OB. Recent advances in nonbiofouling PDMS surface modification strategies applicable to microfluidic technology. Technology (Singap World Sci). 2017 03; 5(1):1-12. PMID: 28695160.
    Citations: 1     
  15. McCarty WJ, Usta OB, Yarmush ML. A Microfabricated Platform for Generating Physiologically-Relevant Hepatocyte Zonation. Sci Rep. 2016 05 31; 6:26868. PMID: 27240736.
    Citations: 4     Fields:    Translation:AnimalsCells
  16. Bhushan A, Martucci NJ, Usta OB, Yarmush ML. New technologies in drug metabolism and toxicity screening: organ-to-organ interaction. Expert Opin Drug Metab Toxicol. 2016 May; 12(5):475-7. PMID: 26940609.
    Citations: 1     Fields:    Translation:HumansAnimals
  17. McCarty WJ, Prodanov L, Bale SS, Bhushan A, Jindal R, Yarmush ML, Usta OB. Layer-by-layer Collagen Deposition in Microfluidic Devices for Microtissue Stabilization. J Vis Exp. 2015 Sep 29; (103). PMID: 26485274.
    Citations:    Fields:    Translation:HumansAnimalsCells
  18. Prodanov L, Jindal R, Bale SS, Hegde M, McCarty WJ, Golberg I, Bhushan A, Yarmush ML, Usta OB. Long-term maintenance of a microfluidic 3D human liver sinusoid. Biotechnol Bioeng. 2016 Jan; 113(1):241-6. PMID: 26152452.
    Citations: 22     Fields:    Translation:Humans
  19. Chen P, Güven S, Usta OB, Yarmush ML, Demirci U. Biotunable acoustic node assembly of organoids. Adv Healthc Mater. 2015 Sep 16; 4(13):1937-43. PMID: 26149464.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  20. Puts CF, Berendsen TA, Bruinsma BG, Ozer S, Luitje M, Usta OB, Yarmush ML, Uygun K. Polyethylene glycol protects primary hepatocytes during supercooling preservation. Cryobiology. 2015 Aug; 71(1):125-9. PMID: 25936340.
    Citations: 4     Fields:    Translation:AnimalsCells
  21. Bale SS, Sridharan GV, Golberg I, Prodanov L, McCarty WJ, Usta OB, Jindal R, Yarmush ML. A novel low-volume two-chamber microfabricated platform for evaluating drug metabolism and toxicity. Technology (Singap World Sci). 2015 Dec; 3(4):155-162. PMID: 26925437.
    Citations: 6     
  22. Usta OB, McCarty WJ, Bale S, Hegde M, Jindal R, Bhushan A, Golberg I, Yarmush ML. Microengineered cell and tissue systems for drug screening and toxicology applications: Evolution of in-vitro liver technologies. Technology (Singap World Sci). 2015 Mar; 3(1):1-26. PMID: 26167518.
    Citations: 5     
  23. Bale SS, Golberg I, Jindal R, McCarty WJ, Luitje M, Hegde M, Bhushan A, Usta OB, Yarmush ML. Long-term coculture strategies for primary hepatocytes and liver sinusoidal endothelial cells. Tissue Eng Part C Methods. 2015 Apr; 21(4):413-22. PMID: 25233394.
    Citations: 14     Fields:    Translation:AnimalsCells
  24. Berendsen TA, Bruinsma BG, Puts CF, Saeidi N, Usta OB, Uygun BE, Izamis ML, Toner M, Yarmush ML, Uygun K. Supercooling enables long-term transplantation survival following 4 days of liver preservation. Nat Med. 2014 Jul; 20(7):790-3. PMID: 24973919.
    Citations: 16     Fields:    Translation:Animals
  25. Hegde M, Jindal R, Bhushan A, Bale SS, McCarty WJ, Golberg I, Usta OB, Yarmush ML. Dynamic interplay of flow and collagen stabilizes primary hepatocytes culture in a microfluidic platform. Lab Chip. 2014 Jun 21; 14(12):2033-9. PMID: 24770663.
    Citations: 12     Fields:    Translation:AnimalsCells
  26. Bale SS, Vernetti L, Senutovitch N, Jindal R, Hegde M, Gough A, McCarty WJ, Bakan A, Bhushan A, Shun TY, Golberg I, DeBiasio R, Usta BO, Taylor DL, Yarmush ML. In vitro platforms for evaluating liver toxicity. Exp Biol Med (Maywood). 2014 Sep; 239(9):1180-1191. PMID: 24764241.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  27. McCarty WJ, Usta OB, Luitje M, Bale SS, Bhushan A, Hegde M, Golberg I, Jindal R, Yarmush ML. A novel ultrathin collagen nanolayer assembly for 3-D microtissue engineering: Layer-by-layer collagen deposition for long-term stable microfluidic hepatocyte culture. Technology (Singap World Sci). 2014 Mar; 2(1):67-74. PMID: 24932459.
    Citations: 10     
  28. Bhushan A, Senutovitch N, Bale SS, McCarty WJ, Hegde M, Jindal R, Golberg I, Berk Usta O, Yarmush ML, Vernetti L, Gough A, Bakan A, Shun TY, DeBiasio R, Lansing Taylor D. Towards a three-dimensional microfluidic liver platform for predicting drug efficacy and toxicity in humans. Stem Cell Res Ther. 2013; 4 Suppl 1:S16. PMID: 24565476.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  29. Usta OB, Kim Y, Ozer S, Bruinsma BG, Lee J, Demir E, Berendsen TA, Puts CF, Izamis ML, Uygun K, Uygun BE, Yarmush ML. Supercooling as a viable non-freezing cell preservation method of rat hepatocytes. PLoS One. 2013; 8(7):e69334. PMID: 23874947.
    Citations: 9     Fields:    Translation:AnimalsCells
  30. Bhattacharya A, Buxton GA, Usta OB, Balazs AC. Propulsion and trapping of microparticles by active cilia arrays. Langmuir. 2012 Feb 14; 28(6):3217-26. PMID: 22233228.
    Citations: 1     Fields:    
  31. Ghosh R, Buxton GA, Usta OB, Balazs AC, Alexeev A. Designing oscillating cilia that capture or release microscopic particles. Langmuir. 2010 Feb 16; 26(4):2963-8. PMID: 19799457.
    Citations: 3     Fields:    Translation:AnimalsCells
  32. Bhattacharya A, Usta OB, Yashin VV, Balazs AC. Self-sustained motion of a train of haptotactic microcapsules. Langmuir. 2009 Sep 01; 25(17):9644-7. PMID: 19705878.
    Citations:    Fields:    Translation:Cells
  33. Usta OB, Perchak D, Clarke A, Yeomans JM, Balazs AC. Shear and extensional deformation of droplets containing polymers and nanoparticles. J Chem Phys. 2009 Jun 21; 130(23):234905. PMID: 19548754.
    Citations:    Fields:    
  34. Usta OB, Nayhouse M, Alexeev A, Balazs AC. Designing patterned substrates to regulate the movement of capsules in microchannels. J Chem Phys. 2008 Jun 21; 128(23):235102. PMID: 18570531.
    Citations:    Fields:    
  35. Usta OB, Alexeev A, Zhu G, Balazs AC. Modeling microcapsules that communicate through nanoparticles to undergo self-propelled motion. ACS Nano. 2008 Mar; 2(3):471-6. PMID: 19206572.
    Citations: 3     Fields:    Translation:Cells
  36. Usta OB, Alexeev A, Balazs AC. Fork in the road: patterned surfaces direct microcapsules to make a decision. Langmuir. 2007 Oct 23; 23(22):10887-90. PMID: 17880118.
    Citations:    Fields:    
  37. Usta OB, Butler JE, Ladd AJ. Transverse migration of a confined polymer driven by an external force. Phys Rev Lett. 2007 Mar 02; 98(9):098301. PMID: 17359205.
    Citations: 3     Fields:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.