Harvard Catalyst Profiles

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Philip Reed Larsen, M.D.

Concepts

This page shows the publications Philip Larsen has written about Transfection.
Connection Strength

0.309
  1. The role of selenocysteine 133 in catalysis by the human type 2 iodothyronine deiodinase. Endocrinology. 2000 Dec; 141(12):4606-12.
    View in: PubMed
    Score: 0.028
  2. Substrate-induced down-regulation of human type 2 deiodinase (hD2) is mediated through proteasomal degradation and requires interaction with the enzyme's active center. Endocrinology. 2000 Mar; 141(3):1127-35.
    View in: PubMed
    Score: 0.027
  3. Is there a negative TRE in the luciferase reporter cDNA? Thyroid. 1996 Aug; 6(4):325-8.
    View in: PubMed
    Score: 0.021
  4. Structural features of thyroid hormone response elements that increase susceptibility to inhibition by an RTH mutant thyroid hormone receptor. Endocrinology. 1996 Jul; 137(7):2833-41.
    View in: PubMed
    Score: 0.021
  5. Dominant negative inhibition by mutant thyroid hormone receptors is thyroid hormone response element and receptor isoform specific. Mol Endocrinol. 1993 Oct; 7(10):1319-30.
    View in: PubMed
    Score: 0.017
  6. Molecular cloning of the selenocysteine-containing enzyme type I iodothyronine deiodinase. Am J Clin Nutr. 1993 02; 57(2 Suppl):249S-255S.
    View in: PubMed
    Score: 0.016
  7. Cloning and in vitro expression of the human selenoprotein, type I iodothyronine deiodinase. J Clin Endocrinol Metab. 1992 Oct; 75(4):1133-9.
    View in: PubMed
    Score: 0.016
  8. Capacity for cooperative binding of thyroid hormone (T3) receptor dimers defines wild type T3 response elements. Mol Endocrinol. 1992 Apr; 6(4):502-14.
    View in: PubMed
    Score: 0.016
  9. Selenocysteine confers the biochemical properties characteristic of the type I iodothyronine deiodinase. J Biol Chem. 1991 Aug 05; 266(22):14155-8.
    View in: PubMed
    Score: 0.015
  10. Antiestrogens stimulate expression of transiently transfected and endogenous genes in rat pituitary tumor cell lines. Mol Cell Endocrinol. 1991 May; 77(1-3):133-40.
    View in: PubMed
    Score: 0.015
  11. Effects of varying the position of thyroid hormone response elements within the rat growth hormone promoter: implications for positive and negative regulation by 3,5,3'-triiodothyronine. Mol Endocrinol. 1991 Apr; 5(4):542-8.
    View in: PubMed
    Score: 0.015
  12. Type I iodothyronine deiodinase is a selenocysteine-containing enzyme. Nature. 1991 Jan 31; 349(6308):438-40.
    View in: PubMed
    Score: 0.014
  13. Inhibition of thyroid hormone action by a non-hormone binding c-erbA protein generated by alternative mRNA splicing. Nature. 1989 Feb 16; 337(6208):659-61.
    View in: PubMed
    Score: 0.013
  14. Functional characterization of the rat growth hormone promoter elements required for induction by thyroid hormone with and without a co-transfected beta type thyroid hormone receptor. J Biol Chem. 1989 Jan 05; 264(1):178-82.
    View in: PubMed
    Score: 0.012
  15. Multihormonal regulation of the human, rat, and bovine growth hormone promoters: differential effects of 3',5'-cyclic adenosine monophosphate, thyroid hormone, and glucocorticoids. Mol Endocrinol. 1988 Sep; 2(9):792-8.
    View in: PubMed
    Score: 0.012
  16. The thyroid hormone-inactivating deiodinase functions as a homodimer. Mol Endocrinol. 2008 Jun; 22(6):1382-93.
    View in: PubMed
    Score: 0.012
  17. In vivo dimerization of types 1, 2, and 3 iodothyronine selenodeiodinases. Endocrinology. 2003 Mar; 144(3):937-46.
    View in: PubMed
    Score: 0.008
  18. The human type 2 iodothyronine deiodinase is a selenoprotein highly expressed in a mesothelioma cell line. J Biol Chem. 2001 Aug 10; 276(32):30183-7.
    View in: PubMed
    Score: 0.007
  19. Distinct subcellular localization of transiently expressed types 1 and 2 iodothyronine deiodinases as determined by immunofluorescence confocal microscopy. Endocrinology. 2000 Nov; 141(11):4309-12.
    View in: PubMed
    Score: 0.007
  20. Polarized targeting of epithelial cell proteins in thyrocytes and MDCK cells. J Cell Sci. 1999 Apr; 112 ( Pt 8):1247-56.
    View in: PubMed
    Score: 0.006
  21. Differential capacity of wild type promoter elements for binding and trans-activation by retinoic acid and thyroid hormone receptors. Mol Endocrinol. 1992 Oct; 6(10):1527-37.
    View in: PubMed
    Score: 0.004
  22. Identification of a thyroid hormone receptor that is pituitary-specific. Science. 1989 Apr 07; 244(4900):76-9.
    View in: PubMed
    Score: 0.003
  23. Isolation of a cDNA clone encoding a biologically active thyroid hormone receptor. Proc Natl Acad Sci U S A. 1988 Jul; 85(14):5031-5.
    View in: PubMed
    Score: 0.003
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.

Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.