Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Due to system maintenance, login and edit functionaility is currently unavailable

Philip Reed Larsen, M.D.

Concepts

This page shows the publications Philip Larsen has written about Humans.
Connection Strength

0.124
  1. [Central fat deposits contribute to atherosclerosis and insulin resistance and peripheral fat deposits protect against atherosclerosis and insulin resistance in postmenopausal women--secondary publication]. Ugeskr Laeger. 2005 Sep 19; 167(38):3597-601.
    View in: PubMed
    Score: 0.004
  2. Type 2 iodothyronine deiodinase is the major source of plasma T3 in euthyroid humans. J Clin Invest. 2005 Sep; 115(9):2524-33.
    View in: PubMed
    Score: 0.004
  3. Cellular and structural biology of the deiodinases. Thyroid. 2005 Aug; 15(8):777-86.
    View in: PubMed
    Score: 0.003
  4. Transforming growth factor-beta promotes inactivation of extracellular thyroid hormones via transcriptional stimulation of type 3 iodothyronine deiodinase. Mol Endocrinol. 2005 Dec; 19(12):3126-36.
    View in: PubMed
    Score: 0.003
  5. CARs and drugs: a risky combination. Endocrinology. 2005 Mar; 146(3):992-4.
    View in: PubMed
    Score: 0.003
  6. A novel cell type-specific mechanism for thyroid hormone-dependent negative regulation of the human type 1 deiodinase gene. Mol Endocrinol. 2004 Dec; 18(12):2924-36.
    View in: PubMed
    Score: 0.003
  7. Timing and magnitude of increases in levothyroxine requirements during pregnancy in women with hypothyroidism. N Engl J Med. 2004 Jul 15; 351(3):241-9.
    View in: PubMed
    Score: 0.003
  8. Thyroid hormone and adrenergic signaling in the heart. Arq Bras Endocrinol Metabol. 2004 Feb; 48(1):171-5.
    View in: PubMed
    Score: 0.003
  9. Type 3 iodothyronine deiodinase is highly expressed in the human uteroplacental unit and in fetal epithelium. J Clin Endocrinol Metab. 2003 Mar; 88(3):1384-8.
    View in: PubMed
    Score: 0.003
  10. A 21-year-old woman with consumptive hypothyroidism due to a vascular tumor expressing type 3 iodothyronine deiodinase. J Clin Endocrinol Metab. 2002 Oct; 87(10):4457-61.
    View in: PubMed
    Score: 0.003
  11. The mRNA structure has potent regulatory effects on type 2 iodothyronine deiodinase expression. Mol Endocrinol. 2002 Jul; 16(7):1667-79.
    View in: PubMed
    Score: 0.003
  12. High dose of (131)I therapy for the treatment of hyperthyroidism caused by Graves' disease. J Clin Endocrinol Metab. 2002 Mar; 87(3):1073-7.
    View in: PubMed
    Score: 0.003
  13. Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases. Endocr Rev. 2002 Feb; 23(1):38-89.
    View in: PubMed
    Score: 0.003
  14. Type 2 iodothyronin deiodinase transgene expression in the mouse heart causes cardiac-specific thyrotoxicosis. Endocrinology. 2001 Jan; 142(1):13-20.
    View in: PubMed
    Score: 0.003
  15. The human, but not rat, dio2 gene is stimulated by thyroid transcription factor-1 (TTF-1). Mol Endocrinol. 2001 Jan; 15(1):112-24.
    View in: PubMed
    Score: 0.003
  16. The role of selenocysteine 133 in catalysis by the human type 2 iodothyronine deiodinase. Endocrinology. 2000 Dec; 141(12):4606-12.
    View in: PubMed
    Score: 0.003
  17. Severe hypothyroidism caused by type 3 iodothyronine deiodinase in infantile hemangiomas. N Engl J Med. 2000 Jul 20; 343(3):185-9.
    View in: PubMed
    Score: 0.002
  18. Substrate-induced down-regulation of human type 2 deiodinase (hD2) is mediated through proteasomal degradation and requires interaction with the enzyme's active center. Endocrinology. 2000 Mar; 141(3):1127-35.
    View in: PubMed
    Score: 0.002
  19. Characterization of the 5'-flanking and 5'-untranslated regions of the cyclic adenosine 3',5'-monophosphate-responsive human type 2 iodothyronine deiodinase gene. Endocrinology. 2000 Jan; 141(1):229-37.
    View in: PubMed
    Score: 0.002
  20. Thyroid hormone regulates hyperpolarization-activated cyclic nucleotide-gated channel (HCN2) mRNA in the rat heart. Circ Res. 1999 Sep 17; 85(6):498-503.
    View in: PubMed
    Score: 0.002
  21. Cloning and expression of the chicken type 2 iodothyronine 5'-deiodinase. J Biol Chem. 1999 May 14; 274(20):13768-76.
    View in: PubMed
    Score: 0.002
  22. Mutation of the Secys residue 266 in human type 2 selenodeiodinase alters 75Se incorporation without affecting its biochemical properties. Biochimie. 1999 May; 81(5):535-8.
    View in: PubMed
    Score: 0.002
  23. The 3'-untranslated region of human type 2 iodothyronine deiodinase mRNA contains a functional selenocysteine insertion sequence element. J Biol Chem. 1998 Dec 11; 273(50):33374-8.
    View in: PubMed
    Score: 0.002
  24. Further characterization of thyroid hormone response elements in the human type 1 iodothyronine deiodinase gene. Endocrinology. 1998 Mar; 139(3):1156-63.
    View in: PubMed
    Score: 0.002
  25. Update on the human iodothyronine selenodeiodinases, the enzymes regulating the activation and inactivation of thyroid hormone. Biochem Soc Trans. 1997 May; 25(2):588-92.
    View in: PubMed
    Score: 0.002
  26. Type 2 iodothyronine deiodinase is highly expressed in human thyroid. J Clin Invest. 1996 Aug 15; 98(4):962-8.
    View in: PubMed
    Score: 0.002
  27. Molecular biological and biochemical characterization of the human type 2 selenodeiodinase. Endocrinology. 1996 Aug; 137(8):3308-15.
    View in: PubMed
    Score: 0.002
  28. Is there a negative TRE in the luciferase reporter cDNA? Thyroid. 1996 Aug; 6(4):325-8.
    View in: PubMed
    Score: 0.002
  29. Structural features of thyroid hormone response elements that increase susceptibility to inhibition by an RTH mutant thyroid hormone receptor. Endocrinology. 1996 Jul; 137(7):2833-41.
    View in: PubMed
    Score: 0.002
  30. The structure of the coding and 5'-flanking region of the type 1 iodothyronine deiodinase (dio1) gene is normal in a patient with suspected congenital dio1 deficiency. J Clin Endocrinol Metab. 1996 Jun; 81(6):2121-4.
    View in: PubMed
    Score: 0.002
  31. Type 3 lodothyronine deiodinase: cloning, in vitro expression, and functional analysis of the placental selenoenzyme. J Clin Invest. 1995 Nov; 96(5):2421-30.
    View in: PubMed
    Score: 0.002
  32. A novel retinoid X receptor-independent thyroid hormone response element is present in the human type 1 deiodinase gene. Mol Cell Biol. 1995 Sep; 15(9):5100-12.
    View in: PubMed
    Score: 0.002
  33. Topological analysis of the integral membrane protein, type 1 iodothyronine deiodinase (D1). J Biol Chem. 1995 May 19; 270(20):12310-8.
    View in: PubMed
    Score: 0.002
  34. Prospective studies of thyroid function in patients receiving gold therapy. Thyroid. 1995 Apr; 5(2):113-6.
    View in: PubMed
    Score: 0.002
  35. Nutritional and hormonal regulation of thyroid hormone deiodinases. Annu Rev Nutr. 1995; 15:323-52.
    View in: PubMed
    Score: 0.002
  36. Identification of critical amino acids for 3,5,3'-triiodothyronine deiodination by human type 1 deiodinase based on comparative functional-structural analyses of the human, dog, and rat enzymes. J Biol Chem. 1994 Aug 12; 269(32):20329-34.
    View in: PubMed
    Score: 0.002
  37. Review of antithyroid drug use during pregnancy and report of a case of aplasia cutis. Thyroid. 1994; 4(1):129-33.
    View in: PubMed
    Score: 0.002
  38. Type I iodothyronine deiodinase: unexpected complexities in a simple deiodination reaction. Thyroid. 1994; 4(3):357-62.
    View in: PubMed
    Score: 0.002
  39. Levothyroxine therapy in patients with thyroid disease. Ann Intern Med. 1993 Sep 15; 119(6):492-502.
    View in: PubMed
    Score: 0.002
  40. Molecular cloning of the selenocysteine-containing enzyme type I iodothyronine deiodinase. Am J Clin Nutr. 1993 02; 57(2 Suppl):249S-255S.
    View in: PubMed
    Score: 0.001
  41. Cloning and in vitro expression of the human selenoprotein, type I iodothyronine deiodinase. J Clin Endocrinol Metab. 1992 Oct; 75(4):1133-9.
    View in: PubMed
    Score: 0.001
  42. The role of selenium in thyroid hormone action. Endocr Rev. 1992 May; 13(2):207-19.
    View in: PubMed
    Score: 0.001
  43. Monitoring thyroxine treatment during pregnancy. Thyroid. 1992; 2(2):153-4.
    View in: PubMed
    Score: 0.001
  44. Recognition of UGA as a selenocysteine codon in type I deiodinase requires sequences in the 3' untranslated region. Nature. 1991 Sep 19; 353(6341):273-6.
    View in: PubMed
    Score: 0.001
  45. Thyroid hormone regulation of gene expression. Annu Rev Physiol. 1991; 53:17-35.
    View in: PubMed
    Score: 0.001
  46. Serum bile acids are higher in humans with prior gastric bypass: potential contribution to improved glucose and lipid metabolism. Obesity (Silver Spring). 2009 Sep; 17(9):1671-7.
    View in: PubMed
    Score: 0.001
  47. The pituitary-thyroid regulatory system. Adv Exp Med Biol. 1989; 261:11-26.
    View in: PubMed
    Score: 0.001
  48. Multihormonal regulation of the human, rat, and bovine growth hormone promoters: differential effects of 3',5'-cyclic adenosine monophosphate, thyroid hormone, and glucocorticoids. Mol Endocrinol. 1988 Sep; 2(9):792-8.
    View in: PubMed
    Score: 0.001
  49. The thyroid hormone-inactivating deiodinase functions as a homodimer. Mol Endocrinol. 2008 Jun; 22(6):1382-93.
    View in: PubMed
    Score: 0.001
  50. Lack of association between the type 2 deiodinase A/G polymorphism and hypertensive traits: the Framingham Heart Study. Hypertension. 2008 Apr; 51(4):e22-3.
    View in: PubMed
    Score: 0.001
  51. Thyroid hormone metabolism in the central nervous system. Acta Med Austriaca. 1988; 15 Suppl 1:5-10.
    View in: PubMed
    Score: 0.001
  52. Long-term assessment of a multidisciplinary approach to thyroid nodule diagnostic evaluation. Cancer. 2007 Dec 25; 111(6):508-16.
    View in: PubMed
    Score: 0.001
  53. The type 2 deiodinase (DIO2) A/G polymorphism is not associated with glycemic traits: the Framingham Heart Study. Thyroid. 2007 Mar; 17(3):199-202.
    View in: PubMed
    Score: 0.001
  54. Hypothyroidism after sunitinib treatment for patients with gastrointestinal stromal tumors. Ann Intern Med. 2006 Nov 07; 145(9):660-4.
    View in: PubMed
    Score: 0.001
  55. Prevalence and distribution of carcinoma in patients with solitary and multiple thyroid nodules on sonography. J Clin Endocrinol Metab. 2006 Sep; 91(9):3411-7.
    View in: PubMed
    Score: 0.001
  56. Management of thyroid nodules detected at US: Society of Radiologists in Ultrasound consensus conference statement. Radiology. 2005 Dec; 237(3):794-800.
    View in: PubMed
    Score: 0.001
  57. Lipopolysaccharide induces type 2 iodothyronine deiodinase in the mediobasal hypothalamus: implications for the nonthyroidal illness syndrome. Endocrinology. 2004 Apr; 145(4):1649-55.
    View in: PubMed
    Score: 0.001
  58. Endoplasmic reticulum-associated degradation of the human type 2 iodothyronine deiodinase (D2) is mediated via an association between mammalian UBC7 and the carboxyl region of D2. Mol Endocrinol. 2003 Dec; 17(12):2603-12.
    View in: PubMed
    Score: 0.001
  59. The iodothyronine selenodeiodinases are thioredoxin-fold family proteins containing a glycoside hydrolase clan GH-A-like structure. J Biol Chem. 2003 Sep 19; 278(38):36887-96.
    View in: PubMed
    Score: 0.001
  60. Genetic and biological subgroups of low-stage follicular thyroid cancer. Am J Pathol. 2003 Apr; 162(4):1053-60.
    View in: PubMed
    Score: 0.001
  61. Peripheral adiposity exhibits an independent dominant antiatherogenic effect in elderly women. Circulation. 2003 Apr 01; 107(12):1626-31.
    View in: PubMed
    Score: 0.001
  62. In vivo dimerization of types 1, 2, and 3 iodothyronine selenodeiodinases. Endocrinology. 2003 Mar; 144(3):937-46.
    View in: PubMed
    Score: 0.001
  63. Natural history of benign solid and cystic thyroid nodules. Ann Intern Med. 2003 Feb 18; 138(4):315-8.
    View in: PubMed
    Score: 0.001
  64. Overexpression of type 2 iodothyronine deiodinase in follicular carcinoma as a cause of low circulating free thyroxine levels. J Clin Endocrinol Metab. 2003 Feb; 88(2):594-8.
    View in: PubMed
    Score: 0.001
  65. Human type 3 iodothyronine selenodeiodinase is located in the plasma membrane and undergoes rapid internalization to endosomes. J Biol Chem. 2003 Jan 10; 278(2):1206-11.
    View in: PubMed
    Score: 0.001
  66. The human type 2 iodothyronine deiodinase is a selenoprotein highly expressed in a mesothelioma cell line. J Biol Chem. 2001 Aug 10; 276(32):30183-7.
    View in: PubMed
    Score: 0.001
  67. Relation of severity of maternal hypothyroidism to cognitive development of offspring. J Med Screen. 2001; 8(1):18-20.
    View in: PubMed
    Score: 0.001
  68. Usefulness of ultrasonography in the management of nodular thyroid disease. Ann Intern Med. 2000 Nov 07; 133(9):696-700.
    View in: PubMed
    Score: 0.001
  69. Selective proteolysis of human type 2 deiodinase: a novel ubiquitin-proteasomal mediated mechanism for regulation of hormone activation. Mol Endocrinol. 2000 Nov; 14(11):1697-708.
    View in: PubMed
    Score: 0.001
  70. Distinct subcellular localization of transiently expressed types 1 and 2 iodothyronine deiodinases as determined by immunofluorescence confocal microscopy. Endocrinology. 2000 Nov; 141(11):4309-12.
    View in: PubMed
    Score: 0.001
  71. Structure-activity relationships for thyroid hormone deiodination by mammalian type I iodothyronine deiodinases. Endocrinology. 1997 Jan; 138(1):213-9.
    View in: PubMed
    Score: 0.000
  72. Differential capacity of wild type promoter elements for binding and trans-activation by retinoic acid and thyroid hormone receptors. Mol Endocrinol. 1992 Oct; 6(10):1527-37.
    View in: PubMed
    Score: 0.000
  73. Increased need for thyroxine during pregnancy in women with primary hypothyroidism. N Engl J Med. 1990 Jul 12; 323(2):91-6.
    View in: PubMed
    Score: 0.000
  74. Amiodarone therapy and autoimmune thyroid disease. Increase in a new monoclonal antibody-defined T cell subset. Am J Med. 1986 Jul; 81(1):53-7.
    View in: PubMed
    Score: 0.000
  75. Prevalence of abnormal thyroid function test results in patients with acute medical illnesses. Am J Med. 1982 Jan; 72(1):9-16.
    View in: PubMed
    Score: 0.000
  76. Cost-effectiveness of screening for hypo- and hyperthyroidism in India. Med Decis Making. 1981; 1(1):44-58.
    View in: PubMed
    Score: 0.000
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.

Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.