Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Philip Reed Larsen, M.D.

Concepts

This page shows the publications Philip Larsen has written about Animals.
Connection Strength

0.293
  1. The imprinted gene neuronatin is regulated by metabolic status and associated with obesity. Obesity (Silver Spring). 2010 Jul; 18(7):1289-96.
    View in: PubMed
    Score: 0.010
  2. PYY(3-36) reduces food intake and body weight and improves insulin sensitivity in rodent models of diet-induced obesity. Am J Physiol Regul Integr Comp Physiol. 2006 Aug; 291(2):R367-75.
    View in: PubMed
    Score: 0.008
  3. Cellular and structural biology of the deiodinases. Thyroid. 2005 Aug; 15(8):777-86.
    View in: PubMed
    Score: 0.008
  4. CARs and drugs: a risky combination. Endocrinology. 2005 Mar; 146(3):992-4.
    View in: PubMed
    Score: 0.007
  5. A novel cell type-specific mechanism for thyroid hormone-dependent negative regulation of the human type 1 deiodinase gene. Mol Endocrinol. 2004 Dec; 18(12):2924-36.
    View in: PubMed
    Score: 0.007
  6. Chronic cardiac-specific thyrotoxicosis increases myocardial beta-adrenergic responsiveness. Mol Endocrinol. 2004 Jul; 18(7):1840-9.
    View in: PubMed
    Score: 0.007
  7. Differential influences of peroxisome proliferator-activated receptors gamma and -alpha on food intake and energy homeostasis. Diabetes. 2003 Sep; 52(9):2249-59.
    View in: PubMed
    Score: 0.007
  8. The mRNA structure has potent regulatory effects on type 2 iodothyronine deiodinase expression. Mol Endocrinol. 2002 Jul; 16(7):1667-79.
    View in: PubMed
    Score: 0.006
  9. Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases. Endocr Rev. 2002 Feb; 23(1):38-89.
    View in: PubMed
    Score: 0.006
  10. Regional physiological adaptation of the central nervous system deiodinases to iodine deficiency. Am J Physiol Endocrinol Metab. 2001 Jul; 281(1):E54-61.
    View in: PubMed
    Score: 0.006
  11. Type 2 iodothyronin deiodinase transgene expression in the mouse heart causes cardiac-specific thyrotoxicosis. Endocrinology. 2001 Jan; 142(1):13-20.
    View in: PubMed
    Score: 0.006
  12. The human, but not rat, dio2 gene is stimulated by thyroid transcription factor-1 (TTF-1). Mol Endocrinol. 2001 Jan; 15(1):112-24.
    View in: PubMed
    Score: 0.006
  13. Thyroid hormone regulates hyperpolarization-activated cyclic nucleotide-gated channel (HCN2) mRNA in the rat heart. Circ Res. 1999 Sep 17; 85(6):498-503.
    View in: PubMed
    Score: 0.005
  14. Cloning and expression of the chicken type 2 iodothyronine 5'-deiodinase. J Biol Chem. 1999 May 14; 274(20):13768-76.
    View in: PubMed
    Score: 0.005
  15. Mutation of the Secys residue 266 in human type 2 selenodeiodinase alters 75Se incorporation without affecting its biochemical properties. Biochimie. 1999 May; 81(5):535-8.
    View in: PubMed
    Score: 0.005
  16. Regional expression of the type 3 iodothyronine deiodinase messenger ribonucleic acid in the rat central nervous system and its regulation by thyroid hormone. Endocrinology. 1999 Feb; 140(2):784-90.
    View in: PubMed
    Score: 0.005
  17. The 3'-untranslated region of human type 2 iodothyronine deiodinase mRNA contains a functional selenocysteine insertion sequence element. J Biol Chem. 1998 Dec 11; 273(50):33374-8.
    View in: PubMed
    Score: 0.005
  18. Studies of the hormonal regulation of type 2 5'-iodothyronine deiodinase messenger ribonucleic acid in pituitary tumor cells using semiquantitative reverse transcription-polymerase chain reaction. Endocrinology. 1998 Dec; 139(12):4895-905.
    View in: PubMed
    Score: 0.005
  19. Type 2 iodothyronine deiodinase in rat pituitary tumor cells is inactivated in proteasomes. J Clin Invest. 1998 Dec 01; 102(11):1895-9.
    View in: PubMed
    Score: 0.005
  20. The guanosine monophosphate reductase gene is conserved in rats and its expression increases rapidly in brown adipose tissue during cold exposure. J Biol Chem. 1998 Nov 20; 273(47):31092-6.
    View in: PubMed
    Score: 0.005
  21. The role of the active site cysteine in catalysis by type 1 iodothyronine deiodinase. Endocrinology. 1997 Dec; 138(12):5452-8.
    View in: PubMed
    Score: 0.005
  22. Update on the human iodothyronine selenodeiodinases, the enzymes regulating the activation and inactivation of thyroid hormone. Biochem Soc Trans. 1997 May; 25(2):588-92.
    View in: PubMed
    Score: 0.004
  23. In vivo genomic footprinting of thyroid hormone-responsive genes in pituitary tumor cell lines. Mol Cell Biol. 1996 Aug; 16(8):4465-77.
    View in: PubMed
    Score: 0.004
  24. Is there a negative TRE in the luciferase reporter cDNA? Thyroid. 1996 Aug; 6(4):325-8.
    View in: PubMed
    Score: 0.004
  25. Structural features of thyroid hormone response elements that increase susceptibility to inhibition by an RTH mutant thyroid hormone receptor. Endocrinology. 1996 Jul; 137(7):2833-41.
    View in: PubMed
    Score: 0.004
  26. Enhancement of thyroid hormone receptor isoform specificity by insertion of a distant half-site into a thyroid hormone response element. Endocrinology. 1996 Apr; 137(4):1438-46.
    View in: PubMed
    Score: 0.004
  27. Effect of 3,5,3'-Triiodothyronine (T3) administration on dio1 gene expression and T3 metabolism in normal and type 1 deiodinase-deficient mice. Endocrinology. 1995 Nov; 136(11):4842-9.
    View in: PubMed
    Score: 0.004
  28. Type 3 lodothyronine deiodinase: cloning, in vitro expression, and functional analysis of the placental selenoenzyme. J Clin Invest. 1995 Nov; 96(5):2421-30.
    View in: PubMed
    Score: 0.004
  29. Structural and functional differences in the dio1 gene in mice with inherited type 1 deiodinase deficiency. Mol Endocrinol. 1995 Aug; 9(8):969-80.
    View in: PubMed
    Score: 0.004
  30. Topological analysis of the integral membrane protein, type 1 iodothyronine deiodinase (D1). J Biol Chem. 1995 May 19; 270(20):12310-8.
    View in: PubMed
    Score: 0.004
  31. Pituitary cells respond to thyroid hormone by discrete, gene-specific pathways. Endocrinology. 1995 Apr; 136(4):1488-94.
    View in: PubMed
    Score: 0.004
  32. Nutritional and hormonal regulation of thyroid hormone deiodinases. Annu Rev Nutr. 1995; 15:323-52.
    View in: PubMed
    Score: 0.004
  33. Identification of critical amino acids for 3,5,3'-triiodothyronine deiodination by human type 1 deiodinase based on comparative functional-structural analyses of the human, dog, and rat enzymes. J Biol Chem. 1994 Aug 12; 269(32):20329-34.
    View in: PubMed
    Score: 0.004
  34. Type I iodothyronine deiodinase: unexpected complexities in a simple deiodination reaction. Thyroid. 1994; 4(3):357-62.
    View in: PubMed
    Score: 0.003
  35. Recognition of UGA as a selenocysteine codon in eukaryotes: a review of recent progress. Biochem Soc Trans. 1993 Nov; 21(4):827-32.
    View in: PubMed
    Score: 0.003
  36. Dominant negative inhibition by mutant thyroid hormone receptors is thyroid hormone response element and receptor isoform specific. Mol Endocrinol. 1993 Oct; 7(10):1319-30.
    View in: PubMed
    Score: 0.003
  37. Physiological and genetic analyses of inbred mouse strains with a type I iodothyronine 5' deiodinase deficiency. J Clin Invest. 1993 Sep; 92(3):1517-28.
    View in: PubMed
    Score: 0.003
  38. Functional characterization of the eukaryotic SECIS elements which direct selenocysteine insertion at UGA codons. EMBO J. 1993 Aug; 12(8):3315-22.
    View in: PubMed
    Score: 0.003
  39. The type I iodothyronine 5'-deiodinase messenger ribonucleic acid is localized to the S3 segment of the rat kidney proximal tubule. Endocrinology. 1993 May; 132(5):2136-40.
    View in: PubMed
    Score: 0.003
  40. Molecular cloning of the selenocysteine-containing enzyme type I iodothyronine deiodinase. Am J Clin Nutr. 1993 02; 57(2 Suppl):249S-255S.
    View in: PubMed
    Score: 0.003
  41. Cloning and in vitro expression of the human selenoprotein, type I iodothyronine deiodinase. J Clin Endocrinol Metab. 1992 Oct; 75(4):1133-9.
    View in: PubMed
    Score: 0.003
  42. The role of selenium in thyroid hormone action. Endocr Rev. 1992 May; 13(2):207-19.
    View in: PubMed
    Score: 0.003
  43. Capacity for cooperative binding of thyroid hormone (T3) receptor dimers defines wild type T3 response elements. Mol Endocrinol. 1992 Apr; 6(4):502-14.
    View in: PubMed
    Score: 0.003
  44. Triiodothyronine causes rapid reversal of alpha 1/cyclic adenosine monophosphate synergism on brown adipocyte respiration and type II deiodinase activity. Metabolism. 1991 Dec; 40(12):1327-32.
    View in: PubMed
    Score: 0.003
  45. Recognition of UGA as a selenocysteine codon in type I deiodinase requires sequences in the 3' untranslated region. Nature. 1991 Sep 19; 353(6341):273-6.
    View in: PubMed
    Score: 0.003
  46. Selenocysteine confers the biochemical properties characteristic of the type I iodothyronine deiodinase. J Biol Chem. 1991 Aug 05; 266(22):14155-8.
    View in: PubMed
    Score: 0.003
  47. Photoaffinity labeling of rat type I iodothyronine deiodinase. Endocrinology. 1991 Aug; 129(2):1042-8.
    View in: PubMed
    Score: 0.003
  48. Evidence that cysteine, not selenocysteine, is in the catalytic site of type II iodothyronine deiodinase. Endocrinology. 1991 Jul; 129(1):550-2.
    View in: PubMed
    Score: 0.003
  49. Mice with a targeted deletion of the type 2 deiodinase are insulin resistant and susceptible to diet induced obesity. PLoS One. 2011; 6(6):e20832.
    View in: PubMed
    Score: 0.003
  50. Antiestrogens stimulate expression of transiently transfected and endogenous genes in rat pituitary tumor cell lines. Mol Cell Endocrinol. 1991 May; 77(1-3):133-40.
    View in: PubMed
    Score: 0.003
  51. Effects of varying the position of thyroid hormone response elements within the rat growth hormone promoter: implications for positive and negative regulation by 3,5,3'-triiodothyronine. Mol Endocrinol. 1991 Apr; 5(4):542-8.
    View in: PubMed
    Score: 0.003
  52. Type I iodothyronine deiodinase is a selenocysteine-containing enzyme. Nature. 1991 Jan 31; 349(6308):438-40.
    View in: PubMed
    Score: 0.003
  53. Thyroid hormone regulation of gene expression. Annu Rev Physiol. 1991; 53:17-35.
    View in: PubMed
    Score: 0.003
  54. Long-term characterization of the diet-induced obese and diet-resistant rat model: a polygenetic rat model mimicking the human obesity syndrome. J Endocrinol. 2010 Sep; 206(3):287-96.
    View in: PubMed
    Score: 0.003
  55. Thyroid hormone regulates type I deiodinase messenger RNA in rat liver. Mol Endocrinol. 1990 May; 4(5):743-8.
    View in: PubMed
    Score: 0.003
  56. The novel triple monoamine reuptake inhibitor tesofensine induces sustained weight loss and improves glycemic control in the diet-induced obese rat: comparison to sibutramine and rimonabant. Eur J Pharmacol. 2010 Jun 25; 636(1-3):88-95.
    View in: PubMed
    Score: 0.003
  57. Mutations of the rat growth hormone promoter which increase and decrease response to thyroid hormone define a consensus thyroid hormone response element. Mol Endocrinol. 1989 Dec; 3(12):1996-2004.
    View in: PubMed
    Score: 0.003
  58. Alpha 1- and beta-adrenergic agents cause synergistic stimulation of the iodothyronine deiodinase in rat brown adipocytes. Endocrinology. 1989 Nov; 125(5):2502-9.
    View in: PubMed
    Score: 0.003
  59. Characterization of beta-cell mass and insulin resistance in diet-induced obese and diet-resistant rats. Obesity (Silver Spring). 2010 Feb; 18(2):266-73.
    View in: PubMed
    Score: 0.003
  60. The pituitary-thyroid regulatory system. Adv Exp Med Biol. 1989; 261:11-26.
    View in: PubMed
    Score: 0.002
  61. Multihormonal regulation of the human, rat, and bovine growth hormone promoters: differential effects of 3',5'-cyclic adenosine monophosphate, thyroid hormone, and glucocorticoids. Mol Endocrinol. 1988 Sep; 2(9):792-8.
    View in: PubMed
    Score: 0.002
  62. Phorbol esters, protein kinase C, and thyroxine 5'-deiodinase in brown adipocytes. Am J Physiol. 1988 Mar; 254(3 Pt 1):E323-7.
    View in: PubMed
    Score: 0.002
  63. Hypoxia-inducible factor induces local thyroid hormone inactivation during hypoxic-ischemic disease in rats. J Clin Invest. 2008 Mar; 118(3):975-83.
    View in: PubMed
    Score: 0.002
  64. Thyroid hormone metabolism in the central nervous system. Acta Med Austriaca. 1988; 15 Suppl 1:5-10.
    View in: PubMed
    Score: 0.002
  65. The regional hypothalamic distribution of type II 5'-monodeiodinase in euthyroid and hypothyroid rats. Brain Res. 1987 Sep 08; 420(1):194-8.
    View in: PubMed
    Score: 0.002
  66. Sonic hedgehog-induced type 3 deiodinase blocks thyroid hormone action enhancing proliferation of normal and malignant keratinocytes. Proc Natl Acad Sci U S A. 2007 Sep 04; 104(36):14466-71.
    View in: PubMed
    Score: 0.002
  67. Mice with impaired extrathyroidal thyroxine to 3,5,3'-triiodothyronine conversion maintain normal serum 3,5,3'-triiodothyronine concentrations. Endocrinology. 2007 Mar; 148(3):954-60.
    View in: PubMed
    Score: 0.002
  68. Atypical expression of type 2 iodothyronine deiodinase in thyrotrophs explains the thyroxine-mediated pituitary thyrotropin feedback mechanism. Endocrinology. 2006 Apr; 147(4):1735-43.
    View in: PubMed
    Score: 0.002
  69. Type 1 iodothyronine deiodinase is a sensitive marker of peripheral thyroid status in the mouse. Endocrinology. 2005 Mar; 146(3):1568-75.
    View in: PubMed
    Score: 0.002
  70. Lipopolysaccharide induces type 2 iodothyronine deiodinase in the mediobasal hypothalamus: implications for the nonthyroidal illness syndrome. Endocrinology. 2004 Apr; 145(4):1649-55.
    View in: PubMed
    Score: 0.002
  71. The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue. J Clin Invest. 2001 Nov; 108(9):1379-85.
    View in: PubMed
    Score: 0.001
  72. Transcriptional regulation of iodothyronine deiodinases during embryonic development. Mol Cell Endocrinol. 2001 Oct 25; 183(1-2):1-9.
    View in: PubMed
    Score: 0.001
  73. The human type 2 iodothyronine deiodinase is a selenoprotein highly expressed in a mesothelioma cell line. J Biol Chem. 2001 Aug 10; 276(32):30183-7.
    View in: PubMed
    Score: 0.001
  74. Selective proteolysis of human type 2 deiodinase: a novel ubiquitin-proteasomal mediated mechanism for regulation of hormone activation. Mol Endocrinol. 2000 Nov; 14(11):1697-708.
    View in: PubMed
    Score: 0.001
  75. Distinct subcellular localization of transiently expressed types 1 and 2 iodothyronine deiodinases as determined by immunofluorescence confocal microscopy. Endocrinology. 2000 Nov; 141(11):4309-12.
    View in: PubMed
    Score: 0.001
  76. DARPP-32 and CREB are present in type 2 iodothyronine deiodinase-producing tanycytes: implications for the regulation of type 2 deiodinase activity. Brain Res. 2000 Apr 17; 862(1-2):154-61.
    View in: PubMed
    Score: 0.001
  77. Comparison of thyroxine and 3,3',5'-triiodothyronine metabolism in rat kidney and liver homogenates. Metabolism. 1979 Nov; 28(11):1139-46.
    View in: PubMed
    Score: 0.001
  78. Polarized targeting of epithelial cell proteins in thyrocytes and MDCK cells. J Cell Sci. 1999 Apr; 112 ( Pt 8):1247-56.
    View in: PubMed
    Score: 0.001
  79. Structure-activity relationships for thyroid hormone deiodination by mammalian type I iodothyronine deiodinases. Endocrinology. 1997 Jan; 138(1):213-9.
    View in: PubMed
    Score: 0.001
  80. Characterization of the promoter of the rat sarcoplasmic endoplasmic reticulum Ca2+-ATPase 1 gene and analysis of thyroid hormone responsiveness. J Biol Chem. 1996 Dec 13; 271(50):32048-56.
    View in: PubMed
    Score: 0.001
  81. Differential capacity of wild type promoter elements for binding and trans-activation by retinoic acid and thyroid hormone receptors. Mol Endocrinol. 1992 Oct; 6(10):1527-37.
    View in: PubMed
    Score: 0.001
  82. Thyroid hormone aporeceptor represses T3-inducible promoters and blocks activity of the retinoic acid receptor. New Biol. 1989 Dec; 1(3):329-36.
    View in: PubMed
    Score: 0.001
  83. Identification of a thyroid hormone receptor that is pituitary-specific. Science. 1989 Apr 07; 244(4900):76-9.
    View in: PubMed
    Score: 0.001
  84. Inhibition of thyroid hormone action by a non-hormone binding c-erbA protein generated by alternative mRNA splicing. Nature. 1989 Feb 16; 337(6208):659-61.
    View in: PubMed
    Score: 0.001
  85. Functional characterization of the rat growth hormone promoter elements required for induction by thyroid hormone with and without a co-transfected beta type thyroid hormone receptor. J Biol Chem. 1989 Jan 05; 264(1):178-82.
    View in: PubMed
    Score: 0.001
  86. Isolation of a cDNA clone encoding a biologically active thyroid hormone receptor. Proc Natl Acad Sci U S A. 1988 Jul; 85(14):5031-5.
    View in: PubMed
    Score: 0.001
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.

Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.