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profileDavid Christoper Bragg, Ph.D.

TitleAssistant Professor of Neurology
InstitutionMassachusetts General Hospital
DepartmentNeurology
AddressMassachusetts General Hospital
Neurology, Rm 6217
149 13th Street
Charlestown MA 02129
Phone617/726-5728
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Confocal Microscope Core (MGH) - Core services (9), Instruments (6) and Software (4)

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Vaine CA, Shin D, Liu C, Hendriks WT, Dhakal J, Shin K, Sharma N, Bragg DC. X-linked Dystonia-Parkinsonism patient cells exhibit altered signaling via nuclear factor-kappa B. Neurobiol Dis. 2017 Apr; 100:108-118. PMID: 28017799.
    View in: PubMed
  2. Ito N, Hendriks WT, Dhakal J, Vaine CA, Liu C, Shin D, Shin K, Wakabayashi-Ito N, Dy M, Multhaupt-Buell T, Sharma N, Breakefield XO, Bragg DC. Decreased N-TAF1 expression in X-linked dystonia-parkinsonism patient-specific neural stem cells. Dis Model Mech. 2016 Apr; 9(4):451-62. PMID: 26769797; PMCID: PMC4852502.
  3. Vaughn LS, Bragg DC, Sharma N, Camargos S, Cardoso F, Patel RC. Altered activation of protein kinase PKR and enhanced apoptosis in dystonia cells carrying a mutation in PKR activator protein PACT. J Biol Chem. 2015 Sep 11; 290(37):22543-57. PMID: 26231208; PMCID: PMC4566229 [Available on 09/11/16].
  4. Bragg DC, Sharma N. Update on treatments for dystonia. Curr Neurol Neurosci Rep. 2014 Jun; 14(6):454. PMID: 24744022; PMCID: PMC4477531.
  5. Meeker RB, Bragg DC, Poulton W, Hudson L. Transmigration of macrophages across the choroid plexus epithelium in response to the feline immunodeficiency virus. Cell Tissue Res. 2012 Feb; 347(2):443-55. PMID: 22281685; PMCID: PMC3785230.
  6. Sengel C, Gavarini S, Sharma N, Ozelius LJ, Bragg DC. Dimerization of the DYT6 dystonia protein, THAP1, requires residues within the coiled-coil domain. J Neurochem. 2011 Sep; 118(6):1087-100. PMID: 21752024; PMCID: PMC3166381.
  7. Bragg DC, Armata IA, Nery FC, Breakefield XO, Sharma N. Molecular pathways in dystonia. Neurobiol Dis. 2011 May; 42(2):136-47. PMID: 21134457; PMCID: PMC3073693.
  8. Orlando LR, Ayala R, Kett LR, Curley AA, Duffner J, Bragg DC, Tsai LH, Dunah AW, Young AB. Phosphorylation of the homer-binding domain of group I metabotropic glutamate receptors by cyclin-dependent kinase 5. J Neurochem. 2009 Jul; 110(2):557-69. PMID: 19457112.
    View in: PubMed
  9. Hewett JW, Zeng J, Niland BP, Bragg DC, Breakefield XO. Dystonia-causing mutant torsinA inhibits cell adhesion and neurite extension through interference with cytoskeletal dynamics. Neurobiol Dis. 2006 Apr; 22(1):98-111. PMID: 16361107.
    View in: PubMed
  10. Hudson LC, Bragg DC, Tompkins MB, Meeker RB. Astrocytes and microglia differentially regulate trafficking of lymphocyte subsets across brain endothelial cells. Brain Res. 2005 Oct 05; 1058(1-2):148-60. PMID: 16137663.
    View in: PubMed
  11. Sharma N, Baxter MG, Petravicz J, Bragg DC, Schienda A, Standaert DG, Breakefield XO. Impaired motor learning in mice expressing torsinA with the DYT1 dystonia mutation. J Neurosci. 2005 Jun 01; 25(22):5351-5. PMID: 15930383.
    View in: PubMed
  12. Bragg DC, Kaufman CA, Kock N, Breakefield XO. Inhibition of N-linked glycosylation prevents inclusion formation by the dystonia-related mutant form of torsinA. Mol Cell Neurosci. 2004 Dec; 27(4):417-26. PMID: 15555920.
    View in: PubMed
  13. Meeker RB, Boles JC, Bragg DC, Robertson K, Hall C. Development of neuronal sensitivity to toxins in cerebrospinal fluid from HIV-type 1-infected individuals. AIDS Res Hum Retroviruses. 2004 Oct; 20(10):1072-86. PMID: 15585098.
    View in: PubMed
  14. Bragg DC, Slater DJ, Breakefield XO. TorsinA and early-onset torsion dystonia. Adv Neurol. 2004; 94:87-93. PMID: 14509659.
    View in: PubMed
  15. Bragg DC, Camp SM, Kaufman CA, Wilbur JD, Boston H, Schuback DE, Hanson PI, Sena-Esteves M, Breakefield XO. Perinuclear biogenesis of mutant torsin-A inclusions in cultured cells infected with tetracycline-regulated herpes simplex virus type 1 amplicon vectors. Neuroscience. 2004; 125(3):651-61. PMID: 15099679.
    View in: PubMed
  16. Bragg DC, Hudson LC, Liang YH, Tompkins MB, Fernandes A, Meeker RB. Choroid plexus macrophages proliferate and release toxic factors in response to feline immunodeficiency virus. J Neurovirol. 2002 Jun; 8(3):225-39. PMID: 12053277.
    View in: PubMed
  17. Bragg DC, Childers TA, Tompkins MB, Tompkins WA, Meeker RB. Infection of the choroid plexus by feline immunodeficiency virus. J Neurovirol. 2002 Jun; 8(3):211-24. PMID: 12053276.
    View in: PubMed
  18. Bragg DC, Boles JC, Meeker RB. Destabilization of neuronal calcium homeostasis by factors secreted from choroid plexus macrophage cultures in response to feline immunodeficiency virus. Neurobiol Dis. 2002 Mar; 9(2):173-86. PMID: 11895370.
    View in: PubMed
  19. Meeker RB, Azuma Y, Bragg DC, English RV, Tompkins M. Microglial proliferation in cortical neural cultures exposed to feline immunodeficiency virus. J Neuroimmunol. 1999 Nov 01; 101(1):15-26. PMID: 10580809.
    View in: PubMed
  20. Bragg DC, Meeker RB, Duff BA, English RV, Tompkins MB. Neurotoxicity of FIV and FIV envelope protein in feline cortical cultures. Brain Res. 1999 Jan 23; 816(2):431-7. PMID: 9878865.
    View in: PubMed
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