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profileBarry L. Wanner, Ph.D.

TitleLecturer on Microbiology and Immunobiology, Part-time
InstitutionHarvard Medical School
DepartmentMicrobiology and Immunobiology
AddressHarvard Medical School
Microbiology & Immunobiology
77 Avenue Louis Pasteur
Boston MA 02115
Phone617/432-5093
Fax617/738-7664
vCardDownload vCard (login for email)

Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
RC1GM092047     (WANNER, BARRY L)Sep 30, 2009 - Aug 31, 2012
NIH/NIGMS
Comprehensive Mapping and Annotation of the E. coli Transcriptome
Role: Principal Investigator

U24GM077905     (WANNER, BARRY L)Jun 1, 2006 - May 31, 2010
NIH/NIGMS
Development of the www.EcoliCommunity.org Information Resource
Role: Principal Investigator

R01GM062662     (WANNER, BARRY L)Apr 1, 2002 - Aug 31, 2008
NIH/NIGMS
Genomic-driven Approaches in E.coli Physiology
Role: Principal Investigator

F33AI010093     (WANNER, BARRY L)Jul 31, 1998
NIH/NIAID
REGULATION OF BACTERIAL VIRULENCE GENE EXPRESSION
Role: Principal Investigator

R01GM057695     (WANNER, BARRY L)Jun 1, 1998 - Nov 30, 2002
NIH/NIGMS
PHOSPHATE CONTROL OF THE ESCHERICHIA COLI PHO REGULON
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Ostrov N, Landon M, Guell M, Kuznetsov G, Teramoto J, Cervantes N, Zhou M, Singh K, Napolitano MG, Moosburner M, Shrock E, Pruitt BW, Conway N, Goodman DB, Gardner CL, Tyree G, Gonzales A, Wanner BL, Norville JE, Lajoie MJ, Church GM. Design, synthesis, and testing toward a 57-codon genome. Science. 2016 Aug 19; 353(6301):819-22. PMID: 27540174.
    View in: PubMed
  2. Nakahigashi K, Takai Y, Kimura M, Abe N, Nakayashiki T, Shiwa Y, Yoshikawa H, Wanner BL, Ishihama Y, Mori H. Comprehensive identification of translation start sites by tetracycline-inhibited ribosome profiling. DNA Res. 2016 Jun; 23(3):193-201. PMID: 27013550; PMCID: PMC4909307.
  3. Mori H, Baba T, Yokoyama K, Takeuchi R, Nomura W, Makishi K, Otsuka Y, Dose H, Wanner BL. Identification of essential genes and synthetic lethal gene combinations in Escherichia coli K-12. Methods Mol Biol. 2015; 1279:45-65. PMID: 25636612.
    View in: PubMed
  4. Mori H, Takeuchi R, Otsuka Y, Bowden S, Yokoyama K, Muto A, Libourel I, Wanner BL. Toward Network Biology in E. coli Cell. Adv Exp Med Biol. 2015; 883:155-68. PMID: 26621467.
    View in: PubMed
  5. Otsuka Y, Muto A, Takeuchi R, Okada C, Ishikawa M, Nakamura K, Yamamoto N, Dose H, Nakahigashi K, Tanishima S, Suharnan S, Nomura W, Nakayashiki T, Aref WG, Bochner BR, Conway T, Gribskov M, Kihara D, Rudd KE, Tohsato Y, Wanner BL, Mori H. GenoBase: comprehensive resource database of Escherichia coli K-12. Nucleic Acids Res. 2015 Jan; 43(Database issue):D606-17. PMID: 25399415; PMCID: PMC4383962.
  6. Conway T, Creecy JP, Maddox SM, Grissom JE, Conkle TL, Shadid TM, Teramoto J, San Miguel P, Shimada T, Ishihama A, Mori H, Wanner BL. Unprecedented high-resolution view of bacterial operon architecture revealed by RNA sequencing. MBio. 2014 Jul 08; 5(4):e01442-14. PMID: 25006232; PMCID: PMC4161252.
  7. Takeuchi R, Tamura T, Nakayashiki T, Tanaka Y, Muto A, Wanner BL, Mori H. Colony-live--a high-throughput method for measuring microbial colony growth kinetics--reveals diverse growth effects of gene knockouts in Escherichia coli. BMC Microbiol. 2014 Jun 26; 14:171. PMID: 24964927; PMCID: PMC4096534.
  8. Oh D, Yu Y, Lee H, Wanner BL, Ritchie K. Dynamics of the serine chemoreceptor in the Escherichia coli inner membrane: a high-speed single-molecule tracking study. Biophys J. 2014 Jan 07; 106(1):145-53. PMID: 24411246; PMCID: PMC3907255.
  9. Wanner BL, Teramoto J, Mori H. What hath DNA wrought? CRISPR-CAS gene silencing and engineering from bacteria to humans: comment on "Diversity, evolution, and therapeutic applications of small RNAs in prokaryotic and eukaryotic immune systems" by Edwin L. Cooper and Nicola Overstreet. Phys Life Rev. 2014 Mar; 11(1):144-5; discussion 149-51. PMID: 24365232.
    View in: PubMed
  10. Nakayashiki T, Saito N, Takeuchi R, Kadokura H, Nakahigashi K, Wanner BL, Mori H. The tRNA thiolation pathway modulates the intracellular redox state in Escherichia coli. J Bacteriol. 2013 May; 195(9):2039-49. PMID: 23457245; PMCID: PMC3624572.
  11. Yong HT, Yamamoto N, Takeuchi R, Hsieh YJ, Conrad TM, Datsenko KA, Nakayashiki T, Wanner BL, Mori H. Development of a system for discovery of genetic interactions for essential genes in Escherichia coli K-12. Genes Genet Syst. 2013; 88(4):233-40. PMID: 24463526.
    View in: PubMed
  12. Datsenko KA, Pougach K, Tikhonov A, Wanner BL, Severinov K, Semenova E. Molecular memory of prior infections activates the CRISPR/Cas adaptive bacterial immunity system. Nat Commun. 2012 Jul 10; 3:945. PMID: 22781758.
    View in: PubMed
  13. Wanner B, Vitaro F, Tremblay RE, Turecki G. Childhood trajectories of anxiousness and disruptiveness explain the association between early-life adversity and attempted suicide. Psychol Med. 2012 Nov; 42(11):2373-82. PMID: 22433421.
    View in: PubMed
  14. Wise MJ, Wanner BL. Welcome to microbial informatics and experimentation. Microb Inform Exp. 2011 Jun 14; 1(1):1. PMID: 22587655; PMCID: PMC3298189.
  15. Semenova E, Jore MM, Datsenko KA, Semenova A, Westra ER, Wanner B, van der Oost J, Brouns SJ, Severinov K. Interference by clustered regularly interspaced short palindromic repeat (CRISPR) RNA is governed by a seed sequence. Proc Natl Acad Sci U S A. 2011 Jun 21; 108(25):10098-103. PMID: 21646539; PMCID: PMC3121866.
  16. Vondenhoff GH, Blanchaert B, Geboers S, Kazakov T, Datsenko KA, Wanner BL, Rozenski J, Severinov K, Van Aerschot A. Characterization of peptide chain length and constituency requirements for YejABEF-mediated uptake of microcin C analogues. J Bacteriol. 2011 Jul; 193(14):3618-23. PMID: 21602342; PMCID: PMC3133342.
  17. Tohsato Y, Baba T, Mazaki Y, Ito M, Wanner BL, Mori H. Environmental dependency of gene knockouts on phenotype microarray analysis in Escherichia coli. J Bioinform Comput Biol. 2010 Dec; 8 Suppl 1:83-99. PMID: 21155021.
    View in: PubMed
  18. Pougach K, Semenova E, Bogdanova E, Datsenko KA, Djordjevic M, Wanner BL, Severinov K. Transcription, processing and function of CRISPR cassettes in Escherichia coli. Mol Microbiol. 2010 Sep; 77(6):1367-79. PMID: 20624226; PMCID: PMC2939963.
  19. Rajagopala SV, Yamamoto N, Zweifel AE, Nakamichi T, Huang HK, Mendez-Rios JD, Franca-Koh J, Boorgula MP, Fujita K, Suzuki K, Hu JC, Wanner BL, Mori H, Uetz P. The Escherichia coli K-12 ORFeome: a resource for comparative molecular microbiology. BMC Genomics. 2010 Aug 11; 11:470. PMID: 20701780; PMCID: PMC3091666.
  20. Hsieh YJ, Wanner BL. Global regulation by the seven-component Pi signaling system. Curr Opin Microbiol. 2010 Apr; 13(2):198-203. PMID: 20171928; PMCID: PMC2847643.
  21. Yamamoto N, Nakahigashi K, Nakamichi T, Yoshino M, Takai Y, Touda Y, Furubayashi A, Kinjyo S, Dose H, Hasegawa M, Datsenko KA, Nakayashiki T, Tomita M, Wanner BL, Mori H. Update on the Keio collection of Escherichia coli single-gene deletion mutants. Mol Syst Biol. 2009; 5:335. PMID: 20029369; PMCID: PMC2824493.
  22. Kierzek AM, Zhou L, Wanner BL. Stochastic kinetic model of two component system signalling reveals all-or-none, graded and mixed mode stochastic switching responses. Mol Biosyst. 2010 Mar; 6(3):531-42. PMID: 20174681.
    View in: PubMed
  23. Liu X, Peña Sandoval GR, Wanner BL, Jung WS, Georgellis D, Kwon O. Evidence against the physiological role of acetyl phosphate in the phosphorylation of the ArcA response regulator in Escherichia coli. J Microbiol. 2009 Oct; 47(5):657-62. PMID: 19851741.
    View in: PubMed
  24. Sharma O, Datsenko KA, Ess SC, Zhalnina MV, Wanner BL, Cramer WA. Genome-wide screens: novel mechanisms in colicin import and cytotoxicity. Mol Microbiol. 2009 Aug; 73(4):571-85. PMID: 19650773; PMCID: PMC3100173.
  25. Song Y, Talaty N, Datsenko K, Wanner BL, Cooks RG. In vivo recognition of Bacillus subtilis by desorption electrospray ionization mass spectrometry (DESI-MS). Analyst. 2009 May; 134(5):838-41. PMID: 19381372.
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  26. Butland G, Babu M, Díaz-Mejía JJ, Bohdana F, Phanse S, Gold B, Yang W, Li J, Gagarinova AG, Pogoutse O, Mori H, Wanner BL, Lo H, Wasniewski J, Christopolous C, Ali M, Venn P, Safavi-Naini A, Sourour N, Caron S, Choi JY, Laigle L, Nazarians-Armavil A, Deshpande A, Joe S, Datsenko KA, Yamamoto N, Andrews BJ, Boone C, Ding H, Sheikh B, Moreno-Hagelseib G, Greenblatt JF, Emili A. eSGA: E. coli synthetic genetic array analysis. Nat Methods. 2008 Sep; 5(9):789-95. PMID: 18677321.
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  27. Typas A, Nichols RJ, Siegele DA, Shales M, Collins SR, Lim B, Braberg H, Yamamoto N, Takeuchi R, Wanner BL, Mori H, Weissman JS, Krogan NJ, Gross CA. High-throughput, quantitative analyses of genetic interactions in E. coli. Nat Methods. 2008 Sep; 5(9):781-7. PMID: 19160513; PMCID: PMC2700713.
  28. Hu JC, Aramayo R, Bolser D, Conway T, Elsik CG, Gribskov M, Kelder T, Kihara D, Knight TF, Pico AR, Siegele DA, Wanner BL, Welch RD. The emerging world of wikis. Science. 2008 Jun 06; 320(5881):1289-90. PMID: 18535227.
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  29. Lamarche MG, Wanner BL, Crépin S, Harel J. The phosphate regulon and bacterial virulence: a regulatory network connecting phosphate homeostasis and pathogenesis. FEMS Microbiol Rev. 2008 May; 32(3):461-73. PMID: 18248418.
    View in: PubMed
  30. Kazakov T, Vondenhoff GH, Datsenko KA, Novikova M, Metlitskaya A, Wanner BL, Severinov K. Escherichia coli peptidase A, B, or N can process translation inhibitor microcin C. J Bacteriol. 2008 Apr; 190(7):2607-10. PMID: 18223070; PMCID: PMC2293190.
  31. Baba T, Huan HC, Datsenko K, Wanner BL, Mori H. The applications of systematic in-frame, single-gene knockout mutant collection of Escherichia coli K-12. Methods Mol Biol. 2008; 416:183-94. PMID: 18392968.
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  32. Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K. The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C. J Bacteriol. 2007 Nov; 189(22):8361-5. PMID: 17873039; PMCID: PMC2168686.
  33. Stepanova E, Lee J, Ozerova M, Semenova E, Datsenko K, Wanner BL, Severinov K, Borukhov S. Analysis of promoter targets for Escherichia coli transcription elongation factor GreA in vivo and in vitro. J Bacteriol. 2007 Dec; 189(24):8772-85. PMID: 17766423; PMCID: PMC2168603.
  34. Sharma O, Yamashita E, Zhalnina MV, Zakharov SD, Datsenko KA, Wanner BL, Cramer WA. Structure of the complex of the colicin E2 R-domain and its BtuB receptor. The outer membrane colicin translocon. J Biol Chem. 2007 Aug 10; 282(32):23163-70. PMID: 17548346.
    View in: PubMed
  35. Cui T, Moro-oka N, Ohsumi K, Kodama K, Ohshima T, Ogasawara N, Mori H, Wanner B, Niki H, Horiuchi T. Escherichia coli with a linear genome. EMBO Rep. 2007 Feb; 8(2):181-7. PMID: 17218953; PMCID: PMC1796773.
  36. Arribas-Bosacoma R, Kim SK, Ferrer-Orta C, Blanco AG, Pereira PJ, Gomis-Rüth FX, Wanner BL, Coll M, Solà M. The X-ray crystal structures of two constitutively active mutants of the Escherichia coli PhoB receiver domain give insights into activation. J Mol Biol. 2007 Feb 16; 366(2):626-41. PMID: 17182055; PMCID: PMC1855202.
  37. Fischbach MA, Lin H, Zhou L, Yu Y, Abergel RJ, Liu DR, Raymond KN, Wanner BL, Strong RK, Walsh CT, Aderem A, Smith KD. The pathogen-associated iroA gene cluster mediates bacterial evasion of lipocalin 2. Proc Natl Acad Sci U S A. 2006 Oct 31; 103(44):16502-7. PMID: 17060628; PMCID: PMC1637611.
  38. Hayashi K, Morooka N, Yamamoto Y, Fujita K, Isono K, Choi S, Ohtsubo E, Baba T, Wanner BL, Mori H, Horiuchi T. Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol Syst Biol. 2006; 2:2006.0007. PMID: 16738553; PMCID: PMC1681481.
  39. Baba T, Ara T, Hasegawa M, Takai Y, Okumura Y, Baba M, Datsenko KA, Tomita M, Wanner BL, Mori H. Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection. Mol Syst Biol. 2006; 2:2006.0008. PMID: 16738554; PMCID: PMC1681482.
  40. Riley M, Abe T, Arnaud MB, Berlyn MK, Blattner FR, Chaudhuri RR, Glasner JD, Horiuchi T, Keseler IM, Kosuge T, Mori H, Perna NT, Plunkett G, Rudd KE, Serres MH, Thomas GH, Thomson NR, Wishart D, Wanner BL. Escherichia coli K-12: a cooperatively developed annotation snapshot--2005. Nucleic Acids Res. 2006; 34(1):1-9. PMID: 16397293; PMCID: PMC1325200.
  41. Le Novère N, Finney A, Hucka M, Bhalla US, Campagne F, Collado-Vides J, Crampin EJ, Halstead M, Klipp E, Mendes P, Nielsen P, Sauro H, Shapiro B, Snoep JL, Spence HD, Wanner BL. Minimum information requested in the annotation of biochemical models (MIRIAM). Nat Biotechnol. 2005 Dec; 23(12):1509-15. PMID: 16333295.
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  42. Tong X, Campbell JW, Balázsi G, Kay KA, Wanner BL, Gerdes SY, Oltvai ZN. Genome-scale identification of conditionally essential genes in E. coli by DNA microarrays. Biochem Biophys Res Commun. 2004 Sep 10; 322(1):347-54. PMID: 15313213.
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  43. Zhou L, Zhang K, Wanner BL. Chromosomal expression of foreign and native genes from regulatable promoters in Escherichia coli. Methods Mol Biol. 2004; 267:123-34. PMID: 15269420.
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  44. Zhou L, Lei XH, Bochner BR, Wanner BL. Phenotype microarray analysis of Escherichia coli K-12 mutants with deletions of all two-component systems. J Bacteriol. 2003 Aug; 185(16):4956-72. PMID: 12897016; PMCID: PMC166450.
  45. Ismail W, El-Said Mohamed M, Wanner BL, Datsenko KA, Eisenreich W, Rohdich F, Bacher A, Fuchs G. Functional genomics by NMR spectroscopy. Phenylacetate catabolism in Escherichia coli. Eur J Biochem. 2003 Jul; 270(14):3047-54. PMID: 12846838.
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  46. Hove-Jensen B, Rosenkrantz TJ, Haldimann A, Wanner BL. Escherichia coli phnN, encoding ribose 1,5-bisphosphokinase activity (phosphoribosyl diphosphate forming): dual role in phosphonate degradation and NAD biosynthesis pathways. J Bacteriol. 2003 May; 185(9):2793-801. PMID: 12700258; PMCID: PMC154390.
  47. Oshima T, Aiba H, Masuda Y, Kanaya S, Sugiura M, Wanner BL, Mori H, Mizuno T. Transcriptome analysis of all two-component regulatory system mutants of Escherichia coli K-12. Mol Microbiol. 2002 Oct; 46(1):281-91. PMID: 12366850.
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  48. Kim AD, Baker AS, Dunaway-Mariano D, Metcalf WW, Wanner BL, Martin BM. The 2-aminoethylphosphonate-specific transaminase of the 2-aminoethylphosphonate degradation pathway. J Bacteriol. 2002 Aug; 184(15):4134-40. PMID: 12107130; PMCID: PMC135204.
  49. Khlebnikov A, Datsenko KA, Skaug T, Wanner BL, Keasling JD. Homogeneous expression of the P(BAD) promoter in Escherichia coli by constitutive expression of the low-affinity high-capacity AraE transporter. Microbiology. 2001 Dec; 147(Pt 12):3241-7. PMID: 11739756.
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  50. Haldimann A, Wanner BL. Conditional-replication, integration, excision, and retrieval plasmid-host systems for gene structure-function studies of bacteria. J Bacteriol. 2001 Nov; 183(21):6384-93. PMID: 11591683; PMCID: PMC100134.
  51. Kim SK, Kimura S, Shinagawa H, Nakata A, Lee KS, Wanner BL, Makino K. Dual transcriptional regulation of the Escherichia coli phosphate-starvation-inducible psiE gene of the phosphate regulon by PhoB and the cyclic AMP (cAMP)-cAMP receptor protein complex. J Bacteriol. 2000 Oct; 182(19):5596-9. PMID: 10986267; PMCID: PMC111007.
  52. Datsenko KA, Wanner BL. One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. Proc Natl Acad Sci U S A. 2000 Jun 06; 97(12):6640-5. PMID: 10829079; PMCID: PMC18686.
  53. Lucas RL, Lostroh CP, DiRusso CC, Spector MP, Wanner BL, Lee CA. Multiple factors independently regulate hilA and invasion gene expression in Salmonella enterica serovar typhimurium. J Bacteriol. 2000 Apr; 182(7):1872-82. PMID: 10714991; PMCID: PMC101869.
  54. Lee KS, Song SB, Kim KE, Kim YH, Kim SK, Kho BH, Ko DK, Choi YK, Lee YK, Kim CK, Kim YC, Lim JY, Kim Y, Min KH, Wanner BL. Cloning and characterization of the UDP-sugar hydrolase gene (ushA) of Enterobacter aerogenes IFO 12010. Biochem Biophys Res Commun. 2000 Mar 16; 269(2):526-31. PMID: 10708587.
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  55. Stern RJ, Lee TY, Lee TJ, Yan W, Scherman MS, Vissa VD, Kim SK, Wanner BL, McNeil MR. Conversion of dTDP-4-keto-6-deoxyglucose to free dTDP-4-keto-rhamnose by the rmIC gene products of Escherichia coli and Mycobacterium tuberculosis. Microbiology. 1999 Mar; 145 ( Pt 3):663-71. PMID: 10217500.
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  56. Silva JC, Haldimann A, Prahalad MK, Walsh CT, Wanner BL. In vivo characterization of the type A and B vancomycin-resistant enterococci (VRE) VanRS two-component systems in Escherichia coli: a nonpathogenic model for studying the VRE signal transduction pathways. Proc Natl Acad Sci U S A. 1998 Sep 29; 95(20):11951-6. PMID: 9751771; PMCID: PMC21746.
  57. Lessard IA, Pratt SD, McCafferty DG, Bussiere DE, Hutchins C, Wanner BL, Katz L, Walsh CT. Homologs of the vancomycin resistance D-Ala-D-Ala dipeptidase VanX in Streptomyces toyocaensis, Escherichia coli and Synechocystis: attributes of catalytic efficiency, stereoselectivity and regulation with implications for function. Chem Biol. 1998 Sep; 5(9):489-504. PMID: 9751644.
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  58. Baker AS, Ciocci MJ, Metcalf WW, Kim J, Babbitt PC, Wanner BL, Martin BM, Dunaway-Mariano D. Insights into the mechanism of catalysis by the P-C bond-cleaving enzyme phosphonoacetaldehyde hydrolase derived from gene sequence analysis and mutagenesis. Biochemistry. 1998 Jun 30; 37(26):9305-15. PMID: 9649311.
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  59. Yakovleva GM, Kim SK, Wanner BL. Phosphate-independent expression of the carbon-phosphorus lyase activity of Escherichia coli. Appl Microbiol Biotechnol. 1998 May; 49(5):573-8. PMID: 9650256.
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  60. Haldimann A, Daniels LL, Wanner BL. Use of new methods for construction of tightly regulated arabinose and rhamnose promoter fusions in studies of the Escherichia coli phosphate regulon. J Bacteriol. 1998 Mar; 180(5):1277-86. PMID: 9495769; PMCID: PMC107018.
  61. Lu F, Schumacher MA, Arvidson DN, Haldimann A, Wanner BL, Zalkin H, Brennan RG. Structure-based redesign of corepressor specificity of the Escherichia coli purine repressor by substitution of residue 190. Biochemistry. 1998 Jan 27; 37(4):971-82. PMID: 9454587.
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  62. Haldimann A, Fisher SL, Daniels LL, Walsh CT, Wanner BL. Transcriptional regulation of the Enterococcus faecium BM4147 vancomycin resistance gene cluster by the VanS-VanR two-component regulatory system in Escherichia coli K-12. J Bacteriol. 1997 Sep; 179(18):5903-13. PMID: 9294451; PMCID: PMC179483.
  63. Haldimann A, Prahalad MK, Fisher SL, Kim SK, Walsh CT, Wanner BL. Altered recognition mutants of the response regulator PhoB: a new genetic strategy for studying protein-protein interactions. Proc Natl Acad Sci U S A. 1996 Dec 10; 93(25):14361-6. PMID: 8962056; PMCID: PMC26137.
  64. Kim SK, Wilmes-Riesenberg MR, Wanner BL. Involvement of the sensor kinase EnvZ in the in vivo activation of the response-regulator PhoB by acetyl phosphate. Mol Microbiol. 1996 Oct; 22(1):135-47. PMID: 8899716.
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  65. VanBogelen RA, Olson ER, Wanner BL, Neidhardt FC. Global analysis of proteins synthesized during phosphorus restriction in Escherichia coli. J Bacteriol. 1996 Aug; 178(15):4344-66. PMID: 8755861; PMCID: PMC178200.
  66. Fisher SL, Kim SK, Wanner BL, Walsh CT. Kinetic comparison of the specificity of the vancomycin resistance VanSfor two response regulators, VanR and PhoB. Biochemistry. 1996 Apr 16; 35(15):4732-40. PMID: 8664263.
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  67. Wanner BL. Signal transduction in the control of phosphate-regulated genes of Escherichia coli. Kidney Int. 1996 Apr; 49(4):964-7. PMID: 8691745.
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  68. Metcalf WW, Jiang W, Daniels LL, Kim SK, Haldimann A, Wanner BL. Conditionally replicative and conjugative plasmids carrying lacZ alpha for cloning, mutagenesis, and allele replacement in bacteria. Plasmid. 1996 Jan; 35(1):1-13. PMID: 8693022.
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  69. Jiang W, Metcalf WW, Lee KS, Wanner BL. Molecular cloning, mapping, and regulation of Pho regulon genes for phosphonate breakdown by the phosphonatase pathway of Salmonella typhimurium LT2. J Bacteriol. 1995 Nov; 177(22):6411-21. PMID: 7592415; PMCID: PMC177490.
  70. Fisher SL, Jiang W, Wanner BL, Walsh CT. Cross-talk between the histidine protein kinase VanS and the response regulator PhoB. Characterization and identification of a VanS domain that inhibits activation of PhoB. J Biol Chem. 1995 Sep 29; 270(39):23143-9. PMID: 7559459.
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  71. Wanner BL. Molecular genetics of carbon-phosphorus bond cleavage in bacteria. Biodegradation. 1994 Dec; 5(3-4):175-84. PMID: 7765831.
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  72. Holman TR, Wu Z, Wanner BL, Walsh CT. Identification of the DNA-binding site for the phosphorylated VanR protein required for vancomycin resistance in Enterococcus faecium. Biochemistry. 1994 Apr 19; 33(15):4625-31. PMID: 8161518.
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  73. Metcalf WW, Jiang W, Wanner BL. Use of the rep technique for allele replacement to construct new Escherichia coli hosts for maintenance of R6K gamma origin plasmids at different copy numbers. Gene. 1994 Jan 28; 138(1-2):1-7. PMID: 8125283.
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  74. Steed PM, Wanner BL. Use of the rep technique for allele replacement to construct mutants with deletions of the pstSCAB-phoU operon: evidence of a new role for the PhoU protein in the phosphate regulon. J Bacteriol. 1993 Nov; 175(21):6797-809. PMID: 8226621; PMCID: PMC206803.
  75. Metcalf WW, Wanner BL. Construction of new beta-glucuronidase cassettes for making transcriptional fusions and their use with new methods for allele replacement. Gene. 1993 Jul 15; 129(1):17-25. PMID: 8335256.
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  76. Metcalf WW, Wanner BL. Evidence for a fourteen-gene, phnC to phnP locus for phosphonate metabolism in Escherichia coli. Gene. 1993 Jul 15; 129(1):27-32. PMID: 8335257.
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  77. Metcalf WW, Wanner BL. Mutational analysis of an Escherichia coli fourteen-gene operon for phosphonate degradation, using TnphoA' elements. J Bacteriol. 1993 Jun; 175(11):3430-42. PMID: 8388873; PMCID: PMC204742.
  78. Wanner BL. Gene regulation by phosphate in enteric bacteria. J Cell Biochem. 1993 Jan; 51(1):47-54. PMID: 8432742.
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  79. Wanner BL, Metcalf WW. Molecular genetic studies of a 10.9-kb operon in Escherichia coli for phosphonate uptake and biodegradation. FEMS Microbiol Lett. 1992 Dec 15; 100(1-3):133-9. PMID: 1335942.
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  80. Feng J, Atkinson MR, McCleary W, Stock JB, Wanner BL, Ninfa AJ. Role of phosphorylated metabolic intermediates in the regulation of glutamine synthetase synthesis in Escherichia coli. J Bacteriol. 1992 Oct; 174(19):6061-70. PMID: 1356964; PMCID: PMC207671.
  81. Wilmes-Riesenberg MR, Wanner BL. TnphoA and TnphoA' elements for making and switching fusions for study of transcription, translation, and cell surface localization. J Bacteriol. 1992 Jul; 174(14):4558-75. PMID: 1378054; PMCID: PMC206251.
  82. Wanner BL. Is cross regulation by phosphorylation of two-component response regulator proteins important in bacteria? J Bacteriol. 1992 Apr; 174(7):2053-8. PMID: 1551826; PMCID: PMC205819.
  83. Wanner BL, Wilmes-Riesenberg MR. Involvement of phosphotransacetylase, acetate kinase, and acetyl phosphate synthesis in control of the phosphate regulon in Escherichia coli. J Bacteriol. 1992 Apr; 174(7):2124-30. PMID: 1551836; PMCID: PMC205829.
  84. Lee KS, Metcalf WW, Wanner BL. Evidence for two phosphonate degradative pathways in Enterobacter aerogenes. J Bacteriol. 1992 Apr; 174(8):2501-10. PMID: 1556070; PMCID: PMC205888.
  85. Wanner BL. Genes for phosphonate biodegradation in Escherichia coli. SAAS Bull Biochem Biotechnol. 1992 Jan; 5:1-6. PMID: 1368181.
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  86. Metcalf WW, Wanner BL. Involvement of the Escherichia coli phn (psiD) gene cluster in assimilation of phosphorus in the form of phosphonates, phosphite, Pi esters, and Pi. J Bacteriol. 1991 Jan; 173(2):587-600. PMID: 1846145; PMCID: PMC207049.
  87. Metcalf WW, Steed PM, Wanner BL. Identification of phosphate starvation-inducible genes in Escherichia coli K-12 by DNA sequence analysis of psi::lacZ(Mu d1) transcriptional fusions. J Bacteriol. 1990 Jun; 172(6):3191-200. PMID: 2160940; PMCID: PMC209124.
  88. Agrawal DK, Wanner BL. A phoA structural gene mutation that conditionally affects formation of the enzyme bacterial alkaline phosphatase. J Bacteriol. 1990 Jun; 172(6):3180-90. PMID: 2345142; PMCID: PMC209123.
  89. Chen CM, Ye QZ, Zhu ZM, Wanner BL, Walsh CT. Molecular biology of carbon-phosphorus bond cleavage. Cloning and sequencing of the phn (psiD) genes involved in alkylphosphonate uptake and C-P lyase activity in Escherichia coli B. J Biol Chem. 1990 Mar 15; 265(8):4461-71. PMID: 2155230.
    View in: PubMed
  90. Wanner BL, Boline JA. Mapping and molecular cloning of the phn (psiD) locus for phosphonate utilization in Escherichia coli. J Bacteriol. 1990 Mar; 172(3):1186-96. PMID: 2155195; PMCID: PMC208583.
  91. Wanner BL, Wilmes MR, Young DC. Control of bacterial alkaline phosphatase synthesis and variation in an Escherichia coli K-12 phoR mutant by adenyl cyclase, the cyclic AMP receptor protein, and the phoM operon. J Bacteriol. 1988 Mar; 170(3):1092-102. PMID: 3277944; PMCID: PMC210878.
  92. Wanner BL, Wilmes MR, Hunter E. Molecular cloning of the wild-type phoM operon in Escherichia coli K-12. J Bacteriol. 1988 Jan; 170(1):279-88. PMID: 3275616; PMCID: PMC210639.
  93. Wanner BL, Chang BD. The phoBR operon in Escherichia coli K-12. J Bacteriol. 1987 Dec; 169(12):5569-74. PMID: 2824439; PMCID: PMC213987.
  94. Wanner BL. Molecular cloning of Mu d(bla lacZ) transcriptional and translational fusions. J Bacteriol. 1987 May; 169(5):2026-30. PMID: 3032905; PMCID: PMC212079.
  95. Wackett LP, Wanner BL, Venditti CP, Walsh CT. Involvement of the phosphate regulon and the psiD locus in carbon-phosphorus lyase activity of Escherichia coli K-12. J Bacteriol. 1987 Apr; 169(4):1753-6. PMID: 3549702; PMCID: PMC212012.
  96. Wanner BL. Control of phoR-dependent bacterial alkaline phosphatase clonal variation by the phoM region. J Bacteriol. 1987 Feb; 169(2):900-3. PMID: 3542979; PMCID: PMC211867.
  97. Wanner BL. Bacterial alkaline phosphatase clonal variation in some Escherichia coli K-12 phoR mutant strains. J Bacteriol. 1986 Dec; 168(3):1366-71. PMID: 3536875; PMCID: PMC213647.
  98. Wanner BL. Novel regulatory mutants of the phosphate regulon in Escherichia coli K-12. J Mol Biol. 1986 Sep 05; 191(1):39-58. PMID: 3540312.
    View in: PubMed
  99. Guan CD, Wanner B, Inouye H. Analysis of regulation of phoB expression using a phoB-cat fusion. J Bacteriol. 1983 Nov; 156(2):710-7. PMID: 6313614; PMCID: PMC217887.
  100. Wanner BL. Overlapping and separate controls on the phosphate regulon in Escherichia coli K12. J Mol Biol. 1983 May 25; 166(3):283-308. PMID: 6304324.
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  101. Wanner BL, McSharry R. Phosphate-controlled gene expression in Escherichia coli K12 using Mudl-directed lacZ fusions. J Mol Biol. 1982 Jul 05; 158(3):347-63. PMID: 6813506.
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  102. Wanner BL, Bernstein J. Determining the phoM map location in Escherichia coli K-12 by using a nearby transposon Tn10 insertion. J Bacteriol. 1982 Apr; 150(1):429-32. PMID: 6277871; PMCID: PMC220136.
  103. Wanner BL, Wieder S, McSharry R. Use of bacteriophage transposon Mu d1 to determine the orientation for three proC-linked phosphate-starvation-inducible (psi) genes in Escherichia coli K-12. J Bacteriol. 1981 Apr; 146(1):93-101. PMID: 6260750; PMCID: PMC217056.
  104. Wanner BL, Latterell P. Mutants affected in alkaline phosphatase, expression: evidence for multiple positive regulators of the phosphate regulon in Escherichia coli. Genetics. 1980 Oct; 96(2):353-66. PMID: 7021308; PMCID: PMC1214304.
  105. Wanner BL, Sarthy A, Beckwith J. Escherichia coli pleiotropic mutant that reduces amounts of several periplasmic and outer membrane proteins. J Bacteriol. 1979 Oct; 140(1):229-39. PMID: 387722; PMCID: PMC216800.
  106. Wanner BL, Kodaira R, Neidhardt FC. Regulation of lac operon expression: reappraisal of the theory of catabolite repression. J Bacteriol. 1978 Dec; 136(3):947-54. PMID: 214424; PMCID: PMC218529.
  107. Wanner BL, Kodaira R, Neidhardt FC. Physiological regulation of a decontrolled lac operon. J Bacteriol. 1977 Apr; 130(1):212-22. PMID: 323228; PMCID: PMC235196.
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