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Elena Halley Chartoff, Ph.D.

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Biography
Carnegie Mellon University, Pittsburgh, PAB.S.05/1992Biology
University of Washington, Seattle, WAPh.D.05/2001Neurobiology & Behavior
Harvard Medical School, Belmont, MA09/2004Neuroscience

Overview
My research focuses on understanding the molecular mechanisms underlying depressive-like states that accompany withdrawal from drugs of abuse. Alleviation of aversive withdrawal symptoms is thought to be a primary motivation for continued drug taking. The mesolimbic dopamine system, which includes the nucleus accumbens (NAc), plays an important role in both the rewarding and aversive effects of drugs such as morphine and cocaine. Several independent but complimentery lines of research are being conducted in my lab. First, we are researching the molecular and circuit mechanisms that mediate opioid withdrawal-associated negative affective states, as these have been shown to contribute to maintenance of drug taking and relapse. We focus primarily on the prescription opioid, oxycodone, and we use intravenous drug self-administration to model different aspects of the addictive process. Second, we are interested in the effects of perinatal opioid exposure on molecular, cellular, and behavioral regulation of reward systems in the offspring. Neonatal abstinence syndrome (NAS) is a tragic and ever-increasing crisis in health care, and yet little is known about the immediate or long-tern neurobiological effects. We hypothesize that dysregulated microglia and microglia function contribute to abnormalities associated with perinatal opioid exposure. A third area of research is probing the effects of chronic opioid exposure and withdrawal on sleep stages and dynamics in rats. In people with opioid use disorder (OUD) or in opioid withdrawal, insomnia is described as one of the most debilitating symptoms. And yet little is understood about how this manifests or is regulated. Finally, my group has a long-standing interest in the neuropeptide dynorphin and its receptor, the kappa opioid receptor (KOR). Dyn/KOR systems produce negative affective states including anhedonia, dysphoria, and anxiety. We have demonstrated robust sex differences in the effects of KOR activation within reward-related behaviors and circuits. We are investigating the use of KOR antagonists as potential therapeutics for OUD and stress-related disorders.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21DA048399 (CHARTOFF, ELENA H) Sep 30, 2019 - Aug 31, 2021
    NIH
    Prenatal oxycodone exposure: developmental effects on microglia and addiction-like behavior in rats
    Role: Principal Investigator
  2. R01DA045000 (CHARTOFF, ELENA H) Sep 15, 2017 - Jun 30, 2022
    NIH
    Neurobiological mechanisms of prescription opioid withdrawal
    Role: Principal Investigator
  3. R03DA033526 (CHARTOFF, ELENA H) Jan 1, 2013 - Dec 31, 2014
    NIH
    Sex differences in the aversive effects of kappa-opioid receptor activation
    Role: Principal Investigator
  4. R01DA026552 (CHARTOFF, ELENA H) May 1, 2010 - Mar 28, 2014
    NIH
    Role of dopamine signaling in the mood-related effects of salvinorin A
    Role: Principal Investigator
  5. R03DA023606 (CHARTOFF, ELENA H) Sep 15, 2008 - Sep 29, 2010
    NIH
    Role of AMPA receptors in the nucleus accumbens shell in morphine depedence
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Borrelli KN, Langan CR, Dubinsky KR, Szumlinski KK, Carlezon WA, Chartoff EH, Bryant CD. Intracranial self-stimulation and concomitant behaviors following systemic methamphetamine administration in Hnrnph1 mutant mice. Psychopharmacology (Berl). 2021 Jul; 238(7):2031-2041. PMID: 33758972.
    Citations:    Fields:    Translation:Animals
  2. Alonso-Caraballo Y, Guha SK, Chartoff EH. The neurobiology of abstinence-induced reward-seeking in males and females. Pharmacol Biochem Behav. 2021 01; 200:173088. PMID: 33333134.
    Citations:    Fields:    Translation:HumansAnimals
  3. Mavrikaki M, Lintz T, Constantino N, Page S, Chartoff E. Chronic opioid exposure differentially modulates oxycodone self-administration in male and female rats. Addict Biol. 2021 05; 26(3):e12973. PMID: 33078503.
    Citations: 2     Fields:    
  4. Selley DE, Lazenka MF, Sim-Selley LJ, Secor McVoy JR, Potter DN, Chartoff EH, Carlezon WA, Negus SS. Attenuated dopamine receptor signaling in nucleus accumbens core in a rat model of chemically-induced neuropathy. Neuropharmacology. 2020 04; 166:107935. PMID: 31917153.
    Citations: 5     Fields:    Translation:AnimalsCells
  5. Page S, Mavrikaki MM, Lintz T, Puttick D, Roberts E, Rosen H, Carroll FI, Carlezon WA, Chartoff EH. Behavioral Pharmacology of Novel Kappa Opioid Receptor Antagonists in Rats. Int J Neuropsychopharmacol. 2019 11 01; 22(11):735-745. PMID: 31613314.
    Citations: 10     Fields:    Translation:Animals
  6. Mavrikaki M, Pantano L, Potter D, Rogers-Grazado MA, Anastasiadou E, Slack FJ, Amr SS, Ressler KJ, Daskalakis NP, Chartoff E. Sex-Dependent Changes in miRNA Expression in the Bed Nucleus of the Stria Terminalis Following Stress. Front Mol Neurosci. 2019; 12:236. PMID: 31636537.
    Citations: 5     
  7. Mavrikaki M, Anastasiadou E, Ozdemir RA, Potter D, Helmholz C, Slack FJ, Chartoff EH. Overexpression of miR-9 in the Nucleus Accumbens Increases Oxycodone Self-Administration. Int J Neuropsychopharmacol. 2019 06 03; 22(6):383-393. PMID: 30989210.
    Citations: 5     Fields:    Translation:AnimalsCells
  8. Conway SM, Puttick D, Russell S, Potter D, Roitman MF, Chartoff EH. Females are less sensitive than males to the motivational- and dopamine-suppressing effects of kappa opioid receptor activation. Neuropharmacology. 2019 03 01; 146:231-241. PMID: 30528327.
    Citations: 12     Fields:    Translation:Animals
  9. Becker JB, Chartoff E. Sex differences in neural mechanisms mediating reward and addiction. Neuropsychopharmacology. 2019 01; 44(1):166-183. PMID: 29946108.
    Citations: 64     Fields:    Translation:HumansAnimals
  10. Der-Avakian A, D'Souza MS, Potter DN, Chartoff EH, Carlezon WA, Pizzagalli DA, Markou A. Social defeat disrupts reward learning and potentiates striatal nociceptin/orphanin FQ mRNA in rats. Psychopharmacology (Berl). 2017 05; 234(9-10):1603-1614. PMID: 28280884.
    Citations: 17     Fields:    Translation:HumansAnimals
  11. Mavrikaki M, Pravetoni M, Page S, Potter D, Chartoff E. Oxycodone self-administration in male and female rats. Psychopharmacology (Berl). 2017 Mar; 234(6):977-987. PMID: 28127624.
    Citations: 23     Fields:    Translation:Animals
  12. Russell SE, Puttick DJ, Sawyer AM, Potter DN, Mague S, Carlezon WA, Chartoff EH. Nucleus Accumbens AMPA Receptors Are Necessary for Morphine-Withdrawal-Induced Negative-Affective States in Rats. J Neurosci. 2016 05 25; 36(21):5748-62. PMID: 27225765.
    Citations: 18     Fields:    Translation:Animals
  13. Chartoff EH, McHugh RK. Translational Studies of Sex Differences in Sensitivity to Opioid Addiction. Neuropsychopharmacology. 2016 Jan; 41(1):383-4. PMID: 26657961.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  14. Chartoff EH, Mavrikaki M. Sex Differences in Kappa Opioid Receptor Function and Their Potential Impact on Addiction. Front Neurosci. 2015; 9:466. PMID: 26733781.
    Citations: 33     
  15. Chartoff EH, Ebner SR, Sparrow A, Potter D, Baker PM, Ragozzino ME, Roitman MF. Relative Timing Between Kappa Opioid Receptor Activation and Cocaine Determines the Impact on Reward and Dopamine Release. Neuropsychopharmacology. 2016 Mar; 41(4):989-1002. PMID: 26239494.
    Citations: 18     Fields:    Translation:Animals
  16. Fortin SM, Chartoff EH, Roitman MF. The Aversive Agent Lithium Chloride Suppresses Phasic Dopamine Release Through Central GLP-1 Receptors. Neuropsychopharmacology. 2016 Feb; 41(3):906-15. PMID: 26211731.
    Citations: 19     Fields:    Translation:Animals
  17. Dow AL, Lin TV, Chartoff EH, Potter D, McPhie DL, Van't Veer AV, Knoll AT, Lee KN, Neve RL, Patel TB, Ongur D, Cohen BM, Carlezon WA. Sprouty2 in the dorsal hippocampus regulates neurogenesis and stress responsiveness in rats. PLoS One. 2015; 10(3):e0120693. PMID: 25822989.
    Citations:    Fields:    Translation:AnimalsCells
  18. Yap JJ, Chartoff EH, Holly EN, Potter DN, Carlezon WA, Miczek KA. Social defeat stress-induced sensitization and escalated cocaine self-administration: the role of ERK signaling in the rat ventral tegmental area. Psychopharmacology (Berl). 2015 May; 232(9):1555-69. PMID: 25373870.
    Citations: 16     Fields:    Translation:AnimalsCells
  19. Chartoff EH, Carlezon WA. Drug withdrawal conceptualized as a stressor. Behav Pharmacol. 2014 Sep; 25(5-6):473-92. PMID: 25083570.
    Citations: 8     Fields:    Translation:HumansAnimals
  20. Pravetoni M, Pentel PR, Potter DN, Chartoff EH, Tally L, LeSage MG. Effects of an oxycodone conjugate vaccine on oxycodone self-administration and oxycodone-induced brain gene expression in rats. PLoS One. 2014; 9(7):e101807. PMID: 25025380.
    Citations: 27     Fields:    Translation:AnimalsPHPublic Health
  21. Chartoff EH, Connery HS. It's MORe exciting than mu: crosstalk between mu opioid receptors and glutamatergic transmission in the mesolimbic dopamine system. Front Pharmacol. 2014; 5:116. PMID: 24904419.
    Citations: 37     
  22. Holland FH, Ganguly P, Potter DN, Chartoff EH, Brenhouse HC. Early life stress disrupts social behavior and prefrontal cortex parvalbumin interneurons at an earlier time-point in females than in males. Neurosci Lett. 2014 Apr 30; 566:131-6. PMID: 24565933.
    Citations: 34     Fields:    Translation:AnimalsCells
  23. Sromek AW, Provencher BA, Russell S, Chartoff E, Knapp BI, Bidlack JM, Neumeyer JL. Preliminary pharmacological evaluation of enantiomeric morphinans. ACS Chem Neurosci. 2014 Feb 19; 5(2):93-9. PMID: 24393077.
    Citations: 5     Fields:    Translation:HumansAnimals
  24. Provencher BA, Sromek AW, Li W, Russell S, Chartoff E, Knapp BI, Bidlack JM, Neumeyer JL. Synthesis and pharmacological evaluation of aminothiazolomorphinans at the mu and kappa opioid receptors. J Med Chem. 2013 Nov 14; 56(21):8872-8. PMID: 24107104.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  25. Russell SE, Rachlin AB, Smith KL, Muschamp J, Berry L, Zhao Z, Chartoff EH. Sex differences in sensitivity to the depressive-like effects of the kappa opioid receptor agonist U-50488 in rats. Biol Psychiatry. 2014 Aug 01; 76(3):213-22. PMID: 24090794.
    Citations: 37     Fields:    Translation:AnimalsCells
  26. Cone JJ, Chartoff EH, Potter DN, Ebner SR, Roitman MF. Prolonged high fat diet reduces dopamine reuptake without altering DAT gene expression. PLoS One. 2013; 8(3):e58251. PMID: 23516454.
    Citations: 39     Fields:    Translation:AnimalsCells
  27. Van't Veer A, Bechtholt AJ, Onvani S, Potter D, Wang Y, Liu-Chen LY, Schütz G, Chartoff EH, Rudolph U, Cohen BM, Carlezon WA. Ablation of kappa-opioid receptors from brain dopamine neurons has anxiolytic-like effects and enhances cocaine-induced plasticity. Neuropsychopharmacology. 2013 Jul; 38(8):1585-97. PMID: 23446450.
    Citations: 30     Fields:    Translation:AnimalsCells
  28. Chartoff EH, Damez-Werno D, Sonntag KC, Hassinger L, Kaufmann DE, Peterson J, McPhie D, Cataldo AM, Cohen BM. Detection of intranasally delivered bone marrow-derived mesenchymal stromal cells in the lesioned mouse brain: a cautionary report. Stem Cells Int. 2011; 2011:586586. PMID: 22190964.
    Citations: 7     
  29. Potter DN, Damez-Werno D, Carlezon WA, Cohen BM, Chartoff EH. Repeated exposure to the ?-opioid receptor agonist salvinorin A modulates extracellular signal-regulated kinase and reward sensitivity. Biol Psychiatry. 2011 Oct 15; 70(8):744-753. PMID: 21757186.
    Citations: 40     Fields:    Translation:AnimalsCells
  30. Chartoff E, Sawyer A, Rachlin A, Potter D, Pliakas A, Carlezon WA. Blockade of kappa opioid receptors attenuates the development of depressive-like behaviors induced by cocaine withdrawal in rats. Neuropharmacology. 2012 Jan; 62(1):167-76. PMID: 21736885.
    Citations: 71     Fields:    Translation:Animals
  31. Ebner SR, Roitman MF, Potter DN, Rachlin AB, Chartoff EH. Depressive-like effects of the kappa opioid receptor agonist salvinorin A are associated with decreased phasic dopamine release in the nucleus accumbens. Psychopharmacology (Berl). 2010 Jun; 210(2):241-52. PMID: 20372879.
    Citations: 69     Fields:    Translation:Animals
  32. Carlezon WA, Chartoff E. Perspective: Progress on the study and treatment of depressive illness. Neuropsychopharmacology. 2009 May; 34(6):1361-2. PMID: 19242407.
    Citations: 1     Fields:    Translation:HumansAnimals
  33. Chartoff EH, Barhight MF, Mague SD, Sawyer AM, Carlezon WA. Anatomically dissociable effects of dopamine D1 receptor agonists on reward and relief of withdrawal in morphine-dependent rats. Psychopharmacology (Berl). 2009 Jun; 204(2):227-39. PMID: 19148621.
    Citations: 8     Fields:    Translation:Animals
  34. Do Carmo GP, Folk JE, Rice KC, Chartoff E, Carlezon WA, Negus SS. The selective non-peptidic delta opioid agonist SNC80 does not facilitate intracranial self-stimulation in rats. Eur J Pharmacol. 2009 Feb 14; 604(1-3):58-65. PMID: 19133255.
    Citations: 29     Fields:    Translation:Animals
  35. Chartoff EH, Papadopoulou M, MacDonald ML, Parsegian A, Potter D, Konradi C, Carlezon WA. Desipramine reduces stress-activated dynorphin expression and CREB phosphorylation in NAc tissue. Mol Pharmacol. 2009 Mar; 75(3):704-12. PMID: 19106229.
    Citations: 42     Fields:    Translation:AnimalsCells
  36. Tomasiewicz HC, Todtenkopf MS, Chartoff EH, Cohen BM, Carlezon WA. The kappa-opioid agonist U69,593 blocks cocaine-induced enhancement of brain stimulation reward. Biol Psychiatry. 2008 Dec 01; 64(11):982-8. PMID: 18639235.
    Citations: 50     Fields:    Translation:Animals
  37. Kenny PJ, Chartoff E, Roberto M, Carlezon WA, Markou A. NMDA receptors regulate nicotine-enhanced brain reward function and intravenous nicotine self-administration: role of the ventral tegmental area and central nucleus of the amygdala. Neuropsychopharmacology. 2009 Jan; 34(2):266-81. PMID: 18418357.
    Citations: 65     Fields:    Translation:Animals
  38. Chartoff EH, Potter D, Damez-Werno D, Cohen BM, Carlezon WA. Exposure to the selective kappa-opioid receptor agonist salvinorin A modulates the behavioral and molecular effects of cocaine in rats. Neuropsychopharmacology. 2008 Oct; 33(11):2676-87. PMID: 18185499.
    Citations: 34     Fields:    Translation:Animals
  39. Chartoff EH, Sawyer A, Carlezon WA Jr. Effect of intra-nucleus accumbens shell microinjections of AMPA and the AMPA receptor antagonist NBQX on locomotor activity and place conditioning. Society for Neuroscience. 2008; (Program No. 490.80).
  40. Potter D, Roitman MF, Cohen BM*, Carlezon WA Jr., Chartoff EH. Biphasic effects of the kappa opioid receptor agonist salvinorin A on hedonic state. Society for Neuroscience. 2008.
  41. Carlezon WA, Chartoff EH. Extreme chipping: addiction to a high-fat diet? Biol Psychiatry. 2007 May 01; 61(9):1019-20. PMID: 17434011.
    Citations: 1     Fields:    Translation:Humans
  42. Chartoff E, Laviolette S, Wise R, Williams J . Functional Impact of Drug Dependence on the Mesolimbic Dopamine System and Reward. Winter Conference on Brain Research. 2007; 63.
  43. Carlezon WA, Chartoff EH. Intracranial self-stimulation (ICSS) in rodents to study the neurobiology of motivation. Nat Protoc. 2007; 2(11):2987-95. PMID: 18007634.
    Citations: 173     Fields:    Translation:Animals
  44. Damez-Werno, D Potter, DN Cohen, BM Carlezon, WA Jr. Chartoff, EH. Exposure to the highly selective kappa agonist salvinorin A modulates the behavioral and molecular effects of cocaine in rats. Society for Neuroscience. 2007; 33.
  45. Chartoff EH, Mague SD, Barhight MF, Smith AM, Carlezon WA. Behavioral and molecular effects of dopamine D1 receptor stimulation during naloxone-precipitated morphine withdrawal. J Neurosci. 2006 Jun 14; 26(24):6450-7. PMID: 16775132.
    Citations: 32     Fields:    Translation:AnimalsCells
  46. Chartoff EH, Pliakas AM, Carlezon WA. Microinjection of the L-type calcium channel antagonist diltiazem into the ventral nucleus accumbens shell facilitates cocaine-induced conditioned place preferences. Biol Psychiatry. 2006 Jun 15; 59(12):1236-9. PMID: 16458265.
    Citations: 9     Fields:    Translation:Animals
  47. Chartoff, EH Barhight, MF Carlezon, WA Jr. Mesolimbic microinjections of a dopamine D1 receptor agonist: behavioral effects in morphine-dependent rats. Society for Neuroscience. 2006; 32.
  48. Goussakov I, Chartoff EH, Tsvetkov E, Gerety LP, Meloni EG, Carlezon WA, Bolshakov VY. LTP in the lateral amygdala during cocaine withdrawal. Eur J Neurosci. 2006 Jan; 23(1):239-50. PMID: 16420433.
    Citations: 15     Fields:    Translation:AnimalsCells
  49. Kasim S, Blake BL, Fan X, Chartoff E, Egami K, Breese GR, Hess EJ, Jinnah HA. The role of dopamine receptors in the neurobehavioral syndrome provoked by activation of L-type calcium channels in rodents. Dev Neurosci. 2006; 28(6):505-17. PMID: 17028428.
    Citations: 6     Fields:    Translation:AnimalsCells
  50. Chartoff EH, Heusner CL, Palmiter RD. Dopamine is not required for the hyperlocomotor response to NMDA receptor antagonists. Neuropsychopharmacology. 2005 Jul; 30(7):1324-33. PMID: 15688082.
    Citations: 33     Fields:    Translation:Animals
  51. Pandey SC, Chartoff EH, Carlezon WA, Zou J, Zhang H, Kreibich AS, Blendy JA, Crews FT. CREB gene transcription factors: role in molecular mechanisms of alcohol and drug addiction. Alcohol Clin Exp Res. 2005 Feb; 29(2):176-84. PMID: 15714041.
    Citations: 30     Fields:    Translation:HumansAnimals
  52. Chartoff EH, Szczypka MS, Palmiter RD, Dorsa DM. Endogenous neurotensin attenuates dopamine-dependent locomotion and stereotypy. Brain Res. 2004 Oct 01; 1022(1-2):71-80. PMID: 15353215.
    Citations: 7     Fields:    Translation:Animals
  53. Chartoff, EH Mague, SD Smith, AM Carlezon, WA Jr. Effects of microinjections of a dopamine D1 receptor agonist into the nucleus accumbens on precipitated opiate withdrawal-induced place conditioning in rats. Society for Neuroscience. 2004; 30:805.6.
  54. Chartoff EH, Papadopoulou M, Konradi C, Carlezon WA. Effects of naloxone-precipitated morphine withdrawal on glutamate-mediated signaling in striatal neurons in vitro. Ann N Y Acad Sci. 2003 Nov; 1003:368-71. PMID: 14684463.
    Citations: 1     Fields:    Translation:AnimalsCells
  55. Chartoff EH, Papadopoulou M, Konradi C, Carlezon WA. Dopamine-dependent increases in phosphorylation of cAMP response element binding protein (CREB) during precipitated morphine withdrawal in primary cultures of rat striatum. J Neurochem. 2003 Oct; 87(1):107-18. PMID: 12969258.
    Citations: 21     Fields:    Translation:AnimalsCells
  56. Chartoff, EH Konradi, C Carlezon, WA Jr. Effect of D1 dopamine receptor activation during withdrawal from chronic morphine: enhanced cAMP-mediated signaling in vitro and decreased conditioned place aversion in vivo. 36th Annual Winter Conference on Brain Research. 2003.
  57. Chartoff, EH Mague, SD Carlezon, WA Jr. Effect of dopamine D1 receptor agonists on precipitated opiate withdrawal-induced place aversions in rats. Society for Neuroscience. 2003; 29:110.9.
  58. Pliakas, AM Papadopoulou, M Mague, SD Neve, RL Konradi, C Carlezon, WA Jr. Effects of desipramine associated with decreased CREB function in rat nucleus accumbens and related tissues. Society for Neuroscience. 2003; 29:957.3.
  59. Chartoff EH, Marck BT, Matsumoto AM, Dorsa DM, Palmiter RD. Induction of stereotypy in dopamine-deficient mice requires striatal D1 receptor activation. Proc Natl Acad Sci U S A. 2001 Aug 28; 98(18):10451-6. PMID: 11517332.
    Citations: 31     Fields:    Translation:Animals
  60. Chartoff, EH. Regulation and Role of Neurotensin in the Basal Ganglia. 2001.
  61. Chartoff EH, Ward RP, Dorsa DM. Role of adenosine and N-methyl-D-aspartate receptors in mediating haloperidol-induced gene expression and catalepsy. J Pharmacol Exp Ther. 1999 Nov; 291(2):531-7. PMID: 10525068.
    Citations: 5     Fields:    Translation:Animals
  62. Adams MR, Brandon EP, Chartoff EH, Idzerda RL, Dorsa DM, McKnight GS. Loss of haloperidol induced gene expression and catalepsy in protein kinase A-deficient mice. Proc Natl Acad Sci U S A. 1997 Oct 28; 94(22):12157-61. PMID: 9342379.
    Citations: 21     Fields:    Translation:AnimalsCells
  63. Newfeld SJ, Chartoff EH, Graff JM, Melton DA, Gelbart WM. Mothers against dpp encodes a conserved cytoplasmic protein required in DPP/TGF-beta responsive cells. Development. 1996 Jul; 122(7):2099-108. PMID: 8681791.
    Citations: 40     Fields:    Translation:AnimalsCells
  64. Sekelsky JJ, Newfeld SJ, Raftery LA, Chartoff EH, Gelbart WM. Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster. Genetics. 1995 Mar; 139(3):1347-58. PMID: 7768443.
    Citations: 138     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.