Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Xihong Lin, Ph.D.

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Other Positions

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. U01HG012064 (WENG, ZHIPING) Aug 20, 2021 - May 31, 2026
    Predictive Modeling of the Functional and Phenotypic Impacts of Genetic Variants
    Role: Co-Principal Investigator
  2. T32GM135117 (LIN, XIHONG) Jul 1, 2020 - Jun 30, 2025
    Interdisciplinary training: Statistical Genetics/Genomics and Computational Biology
    Role: Principal Investigator
  3. U19CA203654 (AMOS, CHRISTOPHER I.) Aug 1, 2017 - Mar 31, 2023
    Integrative analysis of lung cancer etiology and risk
    Role: Co-Principal Investigator
  4. U01HG009088 (LIN, XIHONG) May 2, 2016 - Mar 31, 2022
    Powering whole genome sequence-based genetic discovery for common human diseases
    Role: Principal Investigator
  5. R35CA197449 (LIN, XIHONG) Aug 5, 2015 - Jul 31, 2022
    Statistical Methods for Analysis of Massive Genetic and Genomic Data in Cancer Research
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Shi A, Gaynor SM, Dey R, Zhang H, Quick C, Lin X. COVID-19 Spread Mapper: A multi-resolution, unified framework and open-source tool. Bioinformatics. 2022 Mar 04. PMID: 35244140.
    Citations:    Fields:    
  2. McCaw ZR, Gaynor SM, Sun R, Lin X. Leveraging a surrogate outcome to improve inference on a partially missing target outcome. Biometrics. 2022 Feb 26. PMID: 35218565.
    Citations:    Fields:    
  3. Li X, Yung G, Zhou H, Sun R, Li Z, Hou K, Zhang MJ, Liu Y, Arapoglou T, Wang C, Ionita-Laza I, Lin X. A multi-dimensional integrative scoring framework for predicting functional variants in the human genome. Am J Hum Genet. 2022 Mar 03; 109(3):446-456. PMID: 35216679.
    Citations:    Fields:    
  4. Li D, Ren H, Varelmann DJ, Sarin P, Xu P, Wu D, Li Q, Lin X. Risk assessment for acute kidney injury and death among new COVID-19 positive adult patients without chronic kidney disease: retrospective cohort study among three US hospitals. BMJ Open. 2022 02 21; 12(2):e053635. PMID: 35190428.
    Citations:    Fields:    Translation:HumansCells
  5. Wang H, Kurniansyah N, Cade BE, Goodman MO, Chen H, Gottlieb DJ, Gharib SA, Purcell SM, Lin X, Saxena R, Zhu X, Durda P, Tracy R, Liu Y, Taylor KD, Johnson WC, Gabriel S, Smith JD, Aguet F, Ardlie K, Blackwell T, Reiner AP, Rotter JI, Rich SS, Redline S, Sofer T. Upregulated heme biosynthesis increases obstructive sleep apnea severity: a pathway-based Mendelian randomization study. Sci Rep. 2022 01 27; 12(1):1472. PMID: 35087136.
    Citations:    Fields:    Translation:HumansCells
  6. Cade BE, Lee J, Sofer T, Wang H, Zhang M, Chen H, Gharib SA, Gottlieb DJ, Guo X, Lane JM, Liang J, Lin X, Mei H, Patel SR, Purcell SM, Saxena R, Shah NA, Evans DS, Hanis CL, Hillman DR, Mukherjee S, Palmer LJ, Stone KL, Tranah GJ, Abecasis GR, Boerwinkle EA, Correa A, Cupples LA, Kaplan RC, Nickerson DA, North KE, Psaty BM, Rotter JI, Rich SS, Tracy RP, Vasan RS, Wilson JG, Zhu X, Redline S. Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program. Genome Med. 2021 08 26; 13(1):136. PMID: 34446064.
    Citations:    Fields:    Translation:HumansCells
  7. Gao S, Quick C, Guasch-Ferre M, Zhuo Z, Hutchinson JM, Su L, Hu F, Lin X, Christiani D. The Association Between Inflammatory and Oxidative Stress Biomarkers and Plasma Metabolites in a Longitudinal Study of Healthy Male Welders. J Inflamm Res. 2021; 14:2825-2839. PMID: 34234508.
  8. Li D, Gaynor SM, Quick C, Chen JT, Stephenson BJK, Coull BA, Lin X. Identifying US County-level characteristics associated with high COVID-19 burden. BMC Public Health. 2021 05 28; 21(1):1007. PMID: 34049526.
    Citations: 2     Fields:    Translation:HumansCellsPHPublic Health
  9. Du M, Garcia JGN, Christie JD, Xin J, Cai G, Meyer NJ, Zhu Z, Yuan Q, Zhang Z, Su L, Shen S, Dong X, Li H, Hutchinson JN, Tejera P, Lin X, Wang M, Chen F, Christiani DC. Integrative omics provide biological and clinical insights into acute respiratory distress syndrome. Intensive Care Med. 2021 07; 47(7):761-771. PMID: 34032881.
    Citations: 3     Fields:    Translation:HumansCells
  10. Liu Y, Zhang X, Lee J, Smelser D, Cade B, Chen H, Zhou H, Kirchner HL, Lin X, Mukherjee S, Hillman D, Liu CT, Redline S, Sofer T. Genome-wide association study of neck circumference identifies sex-specific loci independent of generalized adiposity. Int J Obes (Lond). 2021 07; 45(7):1532-1541. PMID: 33907307.
    Citations: 2     Fields:    Translation:Humans
  11. Li X, Li Z, Zhou H, Gaynor SM, Liu Y, Chen H, Sun R, Dey R, Arnett DK, Aslibekyan S, Ballantyne CM, Bielak LF, Blangero J, Boerwinkle E, Bowden DW, Broome JG, Conomos MP, Correa A, Cupples LA, Curran JE, Freedman BI, Guo X, Hindy G, Irvin MR, Kardia SLR, Kathiresan S, Khan AT, Kooperberg CL, Laurie CC, Liu XS, Mahaney MC, Manichaikul AW, Martin LW, Mathias RA, McGarvey ST, Mitchell BD, Montasser ME, Moore JE, Morrison AC, O'Connell JR, Palmer ND, Pampana A, Peralta JM, Peyser PA, Psaty BM, Redline S, Rice KM, Rich SS, Smith JA, Tiwari HK, Tsai MY, Vasan RS, Wang FF, Weeks DE, Weng Z, Wilson JG, Yanek LR, Neale BM, Sunyaev SR, Abecasis GR, Rotter JI, Willer CJ, Peloso GM, Natarajan P, Lin X. Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale. Nat Genet. 2020 09; 52(9):969-983. PMID: 32839606.
    Citations: 18     Fields:    Translation:Humans
  12. Chen S, Lin X. Analysis in case-control sequencing association studies with different sequencing depths. Biostatistics. 2020 07 01; 21(3):577-593. PMID: 30590456.
    Citations: 2     Fields:    Translation:Humans
  13. Wang Z, Du M, Yuan Q, Guo Y, Hutchinson JN, Su L, Zheng Y, Wang J, Mucci LA, Lin X, Hou L, Christiani DC. Epigenomic analysis of 5-hydroxymethylcytosine (5hmC) reveals novel DNA methylation markers for lung cancers. Neoplasia. 2020 03; 22(3):154-161. PMID: 32062069.
    Citations: 5     Fields:    Translation:HumansCells
  14. McCaw ZR, Lane JM, Saxena R, Redline S, Lin X. Operating characteristics of the rank-based inverse normal transformation for quantitative trait analysis in genome-wide association studies. Biometrics. 2020 12; 76(4):1262-1272. PMID: 31883270.
    Citations: 15     Fields:    
  15. Gaynor SM, Sun R, Lin X, Quackenbush J. Identification of differentially expressed gene sets using the Generalized Berk-Jones statistic. Bioinformatics. 2019 11 01; 35(22):4568-4576. PMID: 31062858.
    Citations: 2     Fields:    Translation:HumansCells
  16. Sun R, Lin X. Genetic Variant Set-Based Tests Using the Generalized Berk-Jones Statistic with Application to a Genome-Wide Association Study of Breast Cancer. J Am Stat Assoc. 2020; 115(531):1079-1091. PMID: 33041403.
    Citations: 7     
  17. Li Z, Li X, Liu Y, Shen J, Chen H, Zhou H, Morrison AC, Boerwinkle E, Lin X. Dynamic Scan Procedure for Detecting Rare-Variant Association Regions in Whole-Genome Sequencing Studies. Am J Hum Genet. 2019 05 02; 104(5):802-814. PMID: 30982610.
    Citations: 8     Fields:    Translation:Humans
  18. Sun R, Hui S, Bader GD, Lin X, Kraft P. Powerful gene set analysis in GWAS with the Generalized Berk-Jones statistic. PLoS Genet. 2019 03; 15(3):e1007530. PMID: 30875371.
    Citations: 14     Fields:    Translation:Humans
  19. Liu Y, Chen S, Li Z, Morrison AC, Boerwinkle E, Lin X. ACAT: A Fast and Powerful p Value Combination Method for Rare-Variant Analysis in Sequencing Studies. Am J Hum Genet. 2019 03 07; 104(3):410-421. PMID: 30849328.
    Citations: 44     Fields:    Translation:Humans
  20. Carmona JJ, Barfield RT, Panni T, Nwanaji-Enwerem JC, Just AC, Hutchinson JN, Colicino E, Karrasch S, Wahl S, Kunze S, Jafari N, Zheng Y, Hou L, DeMeo DL, Litonjua AA, Vokonas PS, Peters A, Lin X, Schwartz J, Schulz H, Baccarelli AA. Metastable DNA methylation sites associated with longitudinal lung function decline and aging in humans: an epigenome-wide study in the NAS and KORA cohorts. Epigenetics. 2018; 13(10-11):1039-1055. PMID: 30343628.
    Citations: 5     Fields:    Translation:HumansCells
  21. Hu T, Nan B, Lin X. Proportional cross-ratio model. Lifetime Data Anal. 2019 07; 25(3):480-506. PMID: 30194655.
    Citations:    Fields:    Translation:Humans
  22. Gaynor SM, Schwartz J, Lin X. Mediation analysis for common binary outcomes. Stat Med. 2019 02 20; 38(4):512-529. PMID: 30256434.
    Citations: 5     Fields:    Translation:Humans
  23. Sun R, Wang Z, Claus Henn B, Su L, Lu Q, Lin X, Wright RO, Bellinger DC, Kile M, Mazumdar M, Tellez-Rojo MM, Schnaas L, Christiani DC. Identification of novel loci associated with infant cognitive ability. Mol Psychiatry. 2020 11; 25(11):3010-3019. PMID: 30120420.
    Citations: 2     Fields:    Translation:Humans
  24. Wang Z, Wei Y, Zhang R, Su L, Gogarten SM, Liu G, Brennan P, Field JK, McKay JD, Lissowska J, Swiatkowska B, Janout V, Bolca C, Kontic M, Scelo G, Zaridze D, Laurie CC, Doheny KF, Pugh EK, Marosy BA, Hetrick KN, Xiao X, Pikielny C, Hung RJ, Amos CI, Lin X, Christiani DC. Multi-Omics Analysis Reveals a HIF Network and Hub Gene EPAS1 Associated with Lung Adenocarcinoma. EBioMedicine. 2018 Jun; 32:93-101. PMID: 29859855.
    Citations: 17     Fields:    Translation:HumansCells
  25. Peng C, Cardenas A, Rifas-Shiman SL, Hivert MF, Gold DR, Platts-Mills TA, Lin X, Oken E, Baccarelli AA, Litonjua AA, DeMeo DL. Epigenome-wide association study of total serum immunoglobulin E in children: a life course approach. Clin Epigenetics. 2018; 10:55. PMID: 29692868.
    Citations: 15     Fields:    Translation:HumansCells
  26. Chen H, Cade BE, Gleason KJ, Bjonnes AC, Stilp AM, Sofer T, Conomos MP, Ancoli-Israel S, Arens R, Azarbarzin A, Bell GI, Below JE, Chun S, Evans DS, Ewert R, Frazier-Wood AC, Gharib SA, Haba-Rubio J, Hagen EW, Heinzer R, Hillman DR, Johnson WC, Kutalik Z, Lane JM, Larkin EK, Lee SK, Liang J, Loredo JS, Mukherjee S, Palmer LJ, Papanicolaou GJ, Penzel T, Peppard PE, Post WS, Ramos AR, Rice K, Rotter JI, Sands SA, Shah NA, Shin C, Stone KL, Stubbe B, Sul JH, Tafti M, Taylor KD, Teumer A, Thornton TA, Tranah GJ, Wang C, Wang H, Warby SC, Wellman DA, Zee PC, Hanis CL, Laurie CC, Gottlieb DJ, Patel SR, Zhu X, Sunyaev SR, Saxena R, Lin X, Redline S. Multiethnic Meta-Analysis Identifies RAI1 as a Possible Obstructive Sleep Apnea-related Quantitative Trait Locus in Men. Am J Respir Cell Mol Biol. 2018 03; 58(3):391-401. PMID: 29077507.
    Citations: 24     Fields:    Translation:Humans
  27. Sun R, Carroll RJ, Christiani DC, Lin X. Testing for gene-environment interaction under exposure misspecification. Biometrics. 2018 06; 74(2):653-662. PMID: 29120492.
    Citations: 6     Fields:    Translation:HumansPHPublic Health
  28. Barfield R, Shen J, Just AC, Vokonas PS, Schwartz J, Baccarelli AA, VanderWeele TJ, Lin X. Testing for the indirect effect under the null for genome-wide mediation analyses. Genet Epidemiol. 2017 12; 41(8):824-833. PMID: 29082545.
    Citations: 16     Fields:    Translation:HumansCells
  29. Wang Z, Claus Henn B, Wang C, Wei Y, Su L, Sun R, Chen H, Wagner PJ, Lu Q, Lin X, Wright R, Bellinger D, Kile M, Mazumdar M, Tellez-Rojo MM, Schnaas L, Christiani DC. Genome-wide gene by lead exposure interaction analysis identifies UNC5D as a candidate gene for neurodevelopment. Environ Health. 2017 07 28; 16(1):81. PMID: 28754176.
    Citations: 4     Fields:    Translation:HumansCells
  30. Zhang J, Cavallari JM, Fang SC, Weisskopf MG, Lin X, Mittleman MA, Christiani DC. Application of linear mixed-effects model with LASSO to identify metal components associated with cardiac autonomic responses among welders: a repeated measures study. Occup Environ Med. 2017 11; 74(11):810-815. PMID: 28663305.
    Citations: 5     Fields:    Translation:HumansPHPublic Health
  31. Liu Z, Lin X. Multiple phenotype association tests using summary statistics in genome-wide association studies. Biometrics. 2018 03; 74(1):165-175. PMID: 28653391.
    Citations: 16     Fields:    Translation:Humans
  32. Wei Y, Tejera P, Wang Z, Zhang R, Chen F, Su L, Lin X, Bajwa EK, Thompson BT, Christiani DC. A Missense Genetic Variant in LRRC16A/CARMIL1 Improves Acute Respiratory Distress Syndrome Survival by Attenuating Platelet Count Decline. Am J Respir Crit Care Med. 2017 05 15; 195(10):1353-1361. PMID: 27768389.
    Citations: 19     Fields:    Translation:Humans
  33. Barnett I, Mukherjee R, Lin X. The Generalized Higher Criticism for Testing SNP-Set Effects in Genetic Association Studies. J Am Stat Assoc. 2017; 112(517):64-76. PMID: 28736464.
    Citations: 19     
  34. Carmona JJ, Accomando WP, Binder AM, Hutchinson JN, Pantano L, Izzi B, Just AC, Lin X, Schwartz J, Vokonas PS, Amr SS, Baccarelli AA, Michels KB. Empirical comparison of reduced representation bisulfite sequencing and Infinium BeadChip reproducibility and coverage of DNA methylation in humans. NPJ Genom Med. 2017; 2:13. PMID: 29263828.
    Citations: 9     
  35. Cardenas A, Rifas-Shiman SL, Agha G, Hivert MF, Litonjua AA, DeMeo DL, Lin X, Amarasiriwardena CJ, Oken E, Gillman MW, Baccarelli AA. Persistent DNA methylation changes associated with prenatal mercury exposure and cognitive performance during childhood. Sci Rep. 2017 03 21; 7(1):288. PMID: 28325913.
    Citations: 27     Fields:    Translation:HumansCellsPHPublic Health
  36. Zhang J, Liu Z, Umukoro PE, Cavallari JM, Fang SC, Weisskopf MG, Lin X, Mittleman MA, Christiani DC. An epigenome-wide association analysis of cardiac autonomic responses among a population of welders. Epigenetics. 2017 02; 12(2):71-76. PMID: 28075199.
    Citations: 4     Fields:    Translation:HumansCells
  37. Qian ZR, Li T, Ter-Minassian M, Yang J, Chan JA, Brais LK, Masugi Y, Thiaglingam A, Brooks N, Nishihara R, Bonnemarie M, Masuda A, Inamura K, Kim SA, Mima K, Sukawa Y, Dou R, Lin X, Christiani DC, Schmidlin F, Fuchs CS, Mahmood U, Ogino S, Kulke MH. Association Between Somatostatin Receptor Expression and Clinical Outcomes in Neuroendocrine Tumors. Pancreas. 2016 11; 45(10):1386-1393. PMID: 27622342.
    Citations: 41     Fields:    Translation:Humans
  38. Yung G, Lin X. Validity of using ad hoc methods to analyze secondary traits in case-control association studies. Genet Epidemiol. 2016 Dec; 40(8):732-743. PMID: 27670932.
    Citations: 4     Fields:    Translation:Humans
  39. Kachouie NN, Lin X, Christiani DC, Schwartzman A. Detection of Local DNA Copy Number Changes in Lung Cancer Population Analyses Using A Multi-Scale Approach. Commun Stat Case Stud Data Anal Appl. 2015; 1(4):206-216. PMID: 31489360.
  40. Xing C, M McCarthy J, Dupuis J, Adrienne Cupples L, B Meigs J, Lin X, S Allen A. Robust analysis of secondary phenotypes in case-control genetic association studies. Stat Med. 2016 10 15; 35(23):4226-37. PMID: 27241694.
    Citations: 2     Fields:    Translation:Humans
  41. Chen H, Wang C, Conomos MP, Stilp AM, Li Z, Sofer T, Szpiro AA, Chen W, Brehm JM, Celedón JC, Redline S, Papanicolaou GJ, Thornton TA, Laurie CC, Rice K, Lin X. Control for Population Structure and Relatedness for Binary Traits in Genetic Association Studies via Logistic Mixed Models. Am J Hum Genet. 2016 Apr 07; 98(4):653-66. PMID: 27018471.
    Citations: 141     Fields:    Translation:Humans
  42. Umukoro PE, Fan T, Zhang J, Cavallari JM, Fang SC, Lu C, Lin X, Mittleman MA, Schmidt G, Christiani DC. Long-Term Metal PM2.5 Exposures Decrease Cardiac Acceleration and Deceleration Capacities in Welders. J Occup Environ Med. 2016 Mar; 58(3):227-31. PMID: 26949871.
    Citations: 2     Fields:    Translation:HumansPHPublic Health
  43. Umukoro PE, Wong JY, Cavallari JM, Fang SC, Lu C, Lin X, Mittleman MA, Schmidt G, Christiani DC. Are the Associations of Cardiac Acceleration and Deceleration Capacities With Fine Metal Particulate in Welders Mediated by Inflammation? J Occup Environ Med. 2016 Mar; 58(3):232-7. PMID: 26949872.
    Citations: 1     Fields:    Translation:HumansPHPublic Health
  44. Umukoro PE, Cavallari JM, Fang SC, Lu C, Lin X, Mittleman MA, Christiani DC. Short-term metal particulate exposures decrease cardiac acceleration and deceleration capacities in welders: a repeated-measures panel study. Occup Environ Med. 2016 Feb; 73(2):91-6. PMID: 26644456.
    Citations: 4     Fields:    Translation:HumansPHPublic Health
  45. Chen J, Just AC, Schwartz J, Hou L, Jafari N, Sun Z, Kocher JP, Baccarelli A, Lin X. CpGFilter: model-based CpG probe filtering with replicates for epigenome-wide association studies. Bioinformatics. 2016 Feb 01; 32(3):469-71. PMID: 26449931.
    Citations: 12     Fields:    Translation:HumansCells
  46. Lin X, Lee S, Wu MC, Wang C, Chen H, Li Z, Lin X. Test for rare variants by environment interactions in sequencing association studies. Biometrics. 2016 Mar; 72(1):156-64. PMID: 26229047.
    Citations: 35     Fields:    Translation:Humans
  47. Liu CY, Stücker I, Chen C, Goodman G, McHugh MK, D'Amelio AM, Etzel CJ, Li S, Lin X, Christiani DC. Genome-wide Gene-Asbestos Exposure Interaction Association Study Identifies a Common Susceptibility Variant on 22q13.31 Associated with Lung Cancer Risk. Cancer Epidemiol Biomarkers Prev. 2015 Oct; 24(10):1564-73. PMID: 26199339.
    Citations: 10     Fields:    Translation:HumansPHPublic Health
  48. Seow WJ, Pan WC, Kile ML, Tong L, Baccarelli AA, Quamruzzaman Q, Rahman M, Mostofa G, Rakibuz-Zaman M, Kibriya M, Ahsan H, Lin X, Christiani DC. A distinct and replicable variant of the squamous cell carcinoma gene inositol polyphosphate-5-phosphatase modifies the susceptibility of arsenic-associated skin lesions in Bangladesh. Cancer. 2015 Jul 01; 121(13):2222-9. PMID: 25759212.
    Citations: 3     Fields:    Translation:Humans
  49. Wang Z, Choi S, Lee J, Huang YT, Chen F, Zhao Y, Lin X, Neuberg D, Kim J, Christiani DC. Mitochondrial Variations in Non-Small Cell Lung Cancer (NSCLC) Survival. Cancer Inform. 2015; 14(Suppl 1):1-9. PMID: 25657573.
    Citations: 10     
  50. Kachouie NN, Lin X, Schwartzman A. FDR control of detected regions by multiscale matched filtering. Commun Stat Simul Comput. 2017; 46(1):127-144. PMID: 31501637.
  51. Liao SY, Lin X, Christiani DC. Occupational exposures and longitudinal lung function decline. Am J Ind Med. 2015 Jan; 58(1):14-20. PMID: 25384732.
    Citations: 9     Fields:    Translation:HumansPHPublic Health
  52. Sofer T, Dicker L, Lin X. VARIABLE SELECTION FOR HIGH DIMENSIONAL MULTIVARIATE OUTCOMES. Stat Sin. 2014 Oct; 24(4):1633-1654. PMID: 28642637.
    Citations: 6     
  53. Valeri L, Lin X, VanderWeele TJ. Mediation analysis when a continuous mediator is measured with error and the outcome follows a generalized linear model. Stat Med. 2014 Dec 10; 33(28):4875-90. PMID: 25220625.
    Citations: 21     Fields:    
  54. Liao SY, Lin X, Christiani DC. Genome-wide association and network analysis of lung function in the Framingham Heart Study. Genet Epidemiol. 2014 Sep; 38(6):572-8. PMID: 25044411.
    Citations: 9     Fields:    Translation:HumansCells
  55. Cao Y, Lindström S, Schumacher F, Stevens VL, Albanes D, Berndt S, Boeing H, Bueno-de-Mesquita HB, Canzian F, Chamosa S, Chanock SJ, Diver WR, Gapstur SM, Gaziano JM, Giovannucci EL, Haiman CA, Henderson B, Johansson M, Le Marchand L, Palli D, Rosner B, Siddiq A, Stampfer M, Stram DO, Tamimi R, Travis RC, Trichopoulos D, Willett WC, Yeager M, Kraft P, Hsing AW, Pollak M, Lin X, Ma J. Insulin-like growth factor pathway genetic polymorphisms, circulating IGF1 and IGFBP3, and prostate cancer survival. J Natl Cancer Inst. 2014 Jun; 106(6):dju085. PMID: 24824313.
    Citations: 25     Fields:    Translation:HumansCells
  56. Wang C, Zhan X, Bragg-Gresham J, Kang HM, Stambolian D, Chew EY, Branham KE, Heckenlively J, Fulton R, Wilson RK, Mardis ER, Lin X, Swaroop A, Zöllner S, Abecasis GR. Ancestry estimation and control of population stratification for sequence-based association studies. Nat Genet. 2014 Apr; 46(4):409-15. PMID: 24633160.
    Citations: 53     Fields:    Translation:Cells
  57. Wong JY, De Vivo I, Lin X, Grashow R, Cavallari J, Christiani DC. The association between global DNA methylation and telomere length in a longitudinal study of boilermakers. Genet Epidemiol. 2014 Apr; 38(3):254-64. PMID: 24616077.
    Citations: 20     Fields:    Translation:HumansCells
  58. Seow WJ, Kile ML, Baccarelli AA, Pan WC, Byun HM, Mostofa G, Quamruzzaman Q, Rahman M, Lin X, Christiani DC. Epigenome-wide DNA methylation changes with development of arsenic-induced skin lesions in Bangladesh: a case-control follow-up study. Environ Mol Mutagen. 2014 Jul; 55(6):449-56. PMID: 24677489.
    Citations: 19     Fields:    Translation:HumansCells
  59. Wong JY, De Vivo I, Lin X, Fang SC, Christiani DC. The relationship between inflammatory biomarkers and telomere length in an occupational prospective cohort study. PLoS One. 2014; 9(1):e87348. PMID: 24475279.
    Citations: 50     Fields:    Translation:Humans
  60. Wong JY, De Vivo I, Lin X, Christiani DC. Cumulative PM(2.5) exposure and telomere length in workers exposed to welding fumes. J Toxicol Environ Health A. 2014; 77(8):441-55. PMID: 24627998.
    Citations: 21     Fields:    Translation:HumansCellsPHPublic Health
  61. Barnett IJ, Lin X. Analytic P-value calculation for the higher criticism test in finite d problems. Biometrika. 2014; 101(4):964-970. PMID: 25750439.
    Citations: 8     Fields:    
  62. Wang X, Lee S, Zhu X, Redline S, Lin X. GEE-based SNP set association test for continuous and discrete traits in family-based association studies. Genet Epidemiol. 2013 Dec; 37(8):778-86. PMID: 24166731.
    Citations: 37     Fields:    Translation:Humans
  63. Qian ZR, Ter-Minassian M, Chan JA, Imamura Y, Hooshmand SM, Kuchiba A, Morikawa T, Brais LK, Daskalova A, Heafield R, Lin X, Christiani DC, Fuchs CS, Ogino S, Kulke MH. Prognostic significance of MTOR pathway component expression in neuroendocrine tumors. J Clin Oncol. 2013 Sep 20; 31(27):3418-25. PMID: 23980085.
    Citations: 41     Fields:    Translation:Humans
  64. Pan WC, Kile ML, Seow WJ, Lin X, Quamruzzaman Q, Rahman M, Mahiuddin G, Mostofa G, Lu Q, Christiani DC. Genetic susceptible locus in NOTCH2 interacts with arsenic in drinking water on risk of type 2 diabetes. PLoS One. 2013; 8(8):e70792. PMID: 23967108.
    Citations: 7     Fields:    Translation:HumansPHPublic Health
  65. Huang YT, Lin X. Gene set analysis using variance component tests. BMC Bioinformatics. 2013 Jun 28; 14:210. PMID: 23806107.
    Citations: 13     Fields:    Translation:Humans
  66. Lee S, Teslovich TM, Boehnke M, Lin X. General framework for meta-analysis of rare variants in sequencing association studies. Am J Hum Genet. 2013 Jul 11; 93(1):42-53. PMID: 23768515.
    Citations: 113     Fields:    Translation:Humans
  67. Li L, Kabesch M, Bouzigon E, Demenais F, Farrall M, Moffatt MF, Lin X, Liang L. Using eQTL weights to improve power for genome-wide association studies: a genetic study of childhood asthma. Front Genet. 2013; 4:103. PMID: 23755072.
    Citations: 30     
  68. Hu T, Lin X, Nan B. Cross-ratio estimation for bivariate failure times with left truncation. Lifetime Data Anal. 2014 Jan; 20(1):23-37. PMID: 23700275.
    Citations: 2     Fields:    Translation:Humans
  69. Sofer T, Baccarelli A, Cantone L, Coull B, Maity A, Lin X, Schwartz J. Exposure to airborne particulate matter is associated with methylation pattern in the asthma pathway. Epigenomics. 2013 Apr; 5(2):147-54. PMID: 23566092.
    Citations: 33     Fields:    Translation:HumansCellsPHPublic Health
  70. Ter-Minassian M, Chan JA, Hooshmand SM, Brais LK, Daskalova A, Heafield R, Buchanan L, Qian ZR, Fuchs CS, Lin X, Christiani DC, Kulke MH. Clinical presentation, recurrence, and survival in patients with neuroendocrine tumors: results from a prospective institutional database. Endocr Relat Cancer. 2013 Apr; 20(2):187-96. PMID: 23319495.
    Citations: 41     Fields:    Translation:Humans
  71. Lin X, Lee S, Christiani DC, Lin X. Test for interactions between a genetic marker set and environment in generalized linear models. Biostatistics. 2013 Sep; 14(4):667-81. PMID: 23462021.
    Citations: 56     Fields:    Translation:Humans
  72. Dicker L, Lin X. Parallelism, uniqueness, and large-sample asymptotics for the Dantzig selector. Can J Stat. 2013 Mar 01; 41(1):23-35. PMID: 23589664.
  73. Liu CY, Maity A, Lin X, Wright RO, Christiani DC. Design and analysis issues in gene and environment studies. Environ Health. 2012 Dec 19; 11:93. PMID: 23253229.
    Citations: 15     Fields:    Translation:HumansPHPublic Health
  74. Barnett IJ, Lee S, Lin X. Detecting rare variant effects using extreme phenotype sampling in sequencing association studies. Genet Epidemiol. 2013 Feb; 37(2):142-51. PMID: 23184518.
    Citations: 71     Fields:    Translation:Humans
  75. Zhao Y, Chen F, Zhai R, Lin X, Wang Z, Su L, Christiani DC. Correction for population stratification in random forest analysis. Int J Epidemiol. 2012 Dec; 41(6):1798-806. PMID: 23148107.
    Citations: 12     Fields:    Translation:Humans
  76. Sofer T, Maity A, Coull B, Baccarelli A, Schwartz J, Lin X. Multivariate Gene Selection and Testing in Studying the Exposure Effects on a Gene Set. Stat Biosci. 2012 Nov 01; 4(2):319-338. PMID: 23264831.
    Citations: 3     
  77. Seow WJ, Pan WC, Kile ML, Baccarelli AA, Quamruzzaman Q, Rahman M, Mahiuddin G, Mostofa G, Lin X, Christiani DC. Arsenic reduction in drinking water and improvement in skin lesions: a follow-up study in Bangladesh. Environ Health Perspect. 2012 Dec; 120(12):1733-8. PMID: 23060367.
    Citations: 14     Fields:    Translation:HumansPHPublic Health
  78. Zhao Y, Chen F, Zhai R, Lin X, Diao N, Christiani DC. Association test based on SNP set: logistic kernel machine based test vs. principal component analysis. PLoS One. 2012; 7(9):e44978. PMID: 23028716.
    Citations: 9     Fields:    Translation:Humans
  79. Schifano ED, Epstein MP, Bielak LF, Jhun MA, Kardia SL, Peyser PA, Lin X. SNP set association analysis for familial data. Genet Epidemiol. 2012 Dec; 36(8):797-810. PMID: 22968922.
    Citations: 66     Fields:    Translation:HumansCells
  80. Lee S, Emond MJ, Bamshad MJ, Barnes KC, Rieder MJ, Nickerson DA, Christiani DC, Wurfel MM, Lin X. Optimal unified approach for rare-variant association testing with application to small-sample case-control whole-exome sequencing studies. Am J Hum Genet. 2012 Aug 10; 91(2):224-37. PMID: 22863193.
    Citations: 444     Fields:    Translation:Humans
  81. Cai T, Lin X, Carroll RJ. Identifying genetic marker sets associated with phenotypes via an efficient adaptive score test. Biostatistics. 2012 Sep; 13(4):776-90. PMID: 22734045.
    Citations: 13     Fields:    Translation:Humans
  82. Lee S, Wu MC, Lin X. Optimal tests for rare variant effects in sequencing association studies. Biostatistics. 2012 Sep; 13(4):762-75. PMID: 22699862.
    Citations: 315     Fields:    Translation:Humans
  83. Choi H, Wang L, Lin X, Spengler JD, Perera FP. Fetal window of vulnerability to airborne polycyclic aromatic hydrocarbons on proportional intrauterine growth restriction. PLoS One. 2012; 7(4):e35464. PMID: 22545107.
    Citations: 31     Fields:    Translation:Humans
  84. VanderWeele TJ, Asomaning K, Tchetgen Tchetgen EJ, Han Y, Spitz MR, Shete S, Wu X, Gaborieau V, Wang Y, McLaughlin J, Hung RJ, Brennan P, Amos CI, Christiani DC, Lin X. Genetic variants on 15q25.1, smoking, and lung cancer: an assessment of mediation and interaction. Am J Epidemiol. 2012 May 15; 175(10):1013-20. PMID: 22306564.
    Citations: 80     Fields:    Translation:HumansCells
  85. Yu Z, Lin X, Tu W. Semiparametric frailty models for clustered failure time data. Biometrics. 2012 Jun; 68(2):429-36. PMID: 22070739.
    Citations: 3     Fields:    Translation:Humans
  86. Huang YT, Lin X, Liu Y, Chirieac LR, McGovern R, Wain J, Heist R, Skaug V, Zienolddiny S, Haugen A, Su L, Fox EA, Wong KK, Christiani DC. Cigarette smoking increases copy number alterations in nonsmall-cell lung cancer. Proc Natl Acad Sci U S A. 2011 Sep 27; 108(39):16345-50. PMID: 21911369.
    Citations: 29     Fields:    Translation:HumansAnimals
  87. Lin X, Cai T, Wu MC, Zhou Q, Liu G, Christiani DC, Lin X. Kernel machine SNP-set analysis for censored survival outcomes in genome-wide association studies. Genet Epidemiol. 2011 Nov; 35(7):620-31. PMID: 21818772.
    Citations: 34     Fields:    Translation:Humans
  88. Ter-Minassian M, Asomaning K, Zhao Y, Chen F, Su L, Carmella SG, Lin X, Hecht SS, Christiani DC. Genetic variability in the metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) to 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL). Int J Cancer. 2012 Mar 15; 130(6):1338-46. PMID: 21544809.
    Citations: 8     Fields:    Translation:HumansPHPublic Health
  89. Huang YT, Lin X, Chirieac LR, McGovern R, Wain JC, Heist RS, Skaug V, Zienolddiny S, Haugen A, Su L, Christiani DC. Impact on disease development, genomic location and biological function of copy number alterations in non-small cell lung cancer. PLoS One. 2011; 6(8):e22961. PMID: 21829676.
    Citations: 10     Fields:    Translation:Humans
  90. Zhai R, Zhao Y, Liu G, Ter-Minassian M, Wu IC, Wang Z, Su L, Asomaning K, Chen F, Kulke MH, Lin X, Heist RS, Wain JC, Christiani DC. Interactions between environmental factors and polymorphisms in angiogenesis pathway genes in esophageal adenocarcinoma risk: a case-only study. Cancer. 2012 Feb 01; 118(3):804-11. PMID: 21751195.
    Citations: 9     Fields:    Translation:HumansCells
  91. Hu T, Nan B, Lin X, Robins JM. Time-dependent cross ratio estimation for bivariate failure times. Biometrika. 2011 Jun; 98(2):341-354. PMID: 22822258.
    Citations: 9     Fields:    
  92. Ter-Minassian M, Wang Z, Asomaning K, Wu MC, Liu CY, Paulus JK, Liu G, Bradbury PA, Zhai R, Su L, Frauenhoffer CS, Hooshmand SM, De Vivo I, Lin X, Christiani DC, Kulke MH. Genetic associations with sporadic neuroendocrine tumor risk. Carcinogenesis. 2011 Aug; 32(8):1216-22. PMID: 21606320.
    Citations: 11     Fields:    Translation:Humans
  93. Fu S, Yang L, Li P, Hofmann O, Dicker L, Hide W, Lin X, Watkins SM, Ivanov AR, Hotamisligil GS. Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity. Nature. 2011 May 26; 473(7348):528-31. PMID: 21532591.
    Citations: 384     Fields:    Translation:AnimalsCells
  94. Laohaudomchok W, Lin X, Herrick RF, Fang SC, Cavallari JM, Christiani DC, Weisskopf MG. Toenail, blood, and urine as biomarkers of manganese exposure. J Occup Environ Med. 2011 May; 53(5):506-10. PMID: 21494156.
    Citations: 55     Fields:    Translation:HumansPHPublic Health
  95. Schwartzman A, Lin X. The effect of correlation in false discovery rate estimation. Biometrika. 2011 Mar; 98(1):199-214. PMID: 23049127.
    Citations: 33     Fields:    
  96. Cai T, Tonini G, Lin X. Kernel machine approach to testing the significance of multiple genetic markers for risk prediction. Biometrics. 2011 Sep; 67(3):975-86. PMID: 21281275.
    Citations: 28     Fields:    Translation:Humans
  97. Laohaudomchok W, Lin X, Herrick RF, Fang SC, Cavallari JM, Shrairman R, Landau A, Christiani DC, Weisskopf MG. Neuropsychological effects of low-level manganese exposure in welders. Neurotoxicology. 2011 Mar; 32(2):171-9. PMID: 21192973.
    Citations: 28     Fields:    Translation:HumansPHPublic Health
  98. Dicker L, Lin X, Ivanov AR. Increased power for the analysis of label-free LC-MS/MS proteomics data by combining spectral counts and peptide peak attributes. Mol Cell Proteomics. 2010 Dec; 9(12):2704-18. PMID: 20823122.
    Citations: 15     Fields:    
  99. Laohaudomchok W, Cavallari JM, Fang SC, Lin X, Herrick RF, Christiani DC, Weisskopf MG. Assessment of occupational exposure to manganese and other metals in welding fumes by portable X-ray fluorescence spectrometer. J Occup Environ Hyg. 2010 Aug; 7(8):456-65. PMID: 20526948.
    Citations: 10     Fields:    Translation:HumansCellsPHPublic Health
  100. Paulus JK, Zhou W, Kraft P, Johnson BE, Lin X, Christiani DC. Haplotypes of estrogen receptor-beta and risk of non-small cell lung cancer in women. Lung Cancer. 2011 Mar; 71(3):258-63. PMID: 20655613.
    Citations: 3     Fields:    Translation:Humans
  101. Naylor MG, Lin X, Weiss ST, Raby BA, Lange C. Using canonical correlation analysis to discover genetic regulatory variants. PLoS One. 2010 May 13; 5(5):e10395. PMID: 20485529.
    Citations: 8     Fields:    Translation:Humans
  102. Liu CY, Wu MC, Chen F, Ter-Minassian M, Asomaning K, Zhai R, Wang Z, Su L, Heist RS, Kulke MH, Lin X, Liu G, Christiani DC. A Large-scale genetic association study of esophageal adenocarcinoma risk. Carcinogenesis. 2010 Jul; 31(7):1259-63. PMID: 20453000.
    Citations: 26     Fields:    Translation:Humans
  103. Zhai R, Chen F, Liu G, Su L, Kulke MH, Asomaning K, Lin X, Heist RS, Nishioka NS, Sheu CC, Wain JC, Christiani DC. Interactions among genetic variants in apoptosis pathway genes, reflux symptoms, body mass index, and smoking indicate two distinct etiologic patterns of esophageal adenocarcinoma. J Clin Oncol. 2010 May 10; 28(14):2445-51. PMID: 20385987.
    Citations: 22     Fields:    Translation:Humans
    Citations: 5     
  105. Paulus JK, Asomaning K, Kraft P, Johnson BE, Lin X, Christiani DC. Parity and risk of lung cancer in women. Am J Epidemiol. 2010 Mar 01; 171(5):557-63. PMID: 20123687.
    Citations: 19     Fields:    Translation:Humans
  106. Wu MC, Lin X. Prior biological knowledge-based approaches for the analysis of genome-wide expression profiles using gene sets and pathways. Stat Methods Med Res. 2009 Dec; 18(6):577-93. PMID: 20048386.
    Citations: 18     Fields:    Translation:Humans
  107. Huang YT, Heist RS, Chirieac LR, Lin X, Skaug V, Zienolddiny S, Haugen A, Wu MC, Wang Z, Su L, Asomaning K, Christiani DC. Genome-wide analysis of survival in early-stage non-small-cell lung cancer. J Clin Oncol. 2009 Jun 01; 27(16):2660-7. PMID: 19414679.
    Citations: 56     Fields:    Translation:HumansCells
  108. Wang Z, Chen F, Zhai R, Zhang L, Su L, Lin X, Thompson T, Christiani DC. Plasma neutrophil elastase and elafin imbalance is associated with acute respiratory distress syndrome (ARDS) development. PLoS One. 2009; 4(2):e4380. PMID: 19197381.
    Citations: 19     Fields:    Translation:Humans
  109. Wu MC, Zhang L, Wang Z, Christiani DC, Lin X. Sparse linear discriminant analysis for simultaneous testing for the significance of a gene set/pathway and gene selection. Bioinformatics. 2009 May 01; 25(9):1145-51. PMID: 19168911.
    Citations: 23     Fields:    Translation:Humans
  110. Li Y, Tang H, Lin X. Spatial Linear Mixed Models with Covariate Measurement Errors. Stat Sin. 2009; 19(3):1077-1093. PMID: 20046975.
    Citations: 9     
  111. Li Y, Prentice RL, Lin X. Semiparametric Maximum Likelihood Estimation in Normal Transformation Models for Bivariate Survival Data. Biometrika. 2008 Dec; 95(4):947-960. PMID: 19079778.
    Citations: 8     Fields:    
  112. Zhai R, Liu G, Asomaning K, Su L, Kulke MH, Heist RS, Nishioka NS, Lynch TJ, Wain JC, Lin X, Christiani DC. Genetic polymorphisms of VEGF, interactions with cigarette smoking exposure and esophageal adenocarcinoma risk. Carcinogenesis. 2008 Dec; 29(12):2330-4. PMID: 18780893.
    Citations: 27     Fields:    Translation:Humans
  113. Ter-Minassian M, Zhai R, Asomaning K, Su L, Zhou W, Liu G, Heist RS, Lynch TJ, Wain JC, Lin X, De Vivo I, Christiani DC. Apoptosis gene polymorphisms, age, smoking and the risk of non-small cell lung cancer. Carcinogenesis. 2008 Nov; 29(11):2147-52. PMID: 18757527.
    Citations: 30     Fields:    Translation:Humans
  114. Liu D, Ghosh D, Lin X. Estimation and testing for the effect of a genetic pathway on a disease outcome using logistic kernel machine regression via logistic mixed models. BMC Bioinformatics. 2008 Jun 24; 9:292. PMID: 18577223.
    Citations: 97     Fields:    Translation:Humans
  115. Nan B, Lin X. Analysis of case-control age-at-onset data using a modified case-cohort method. Biom J. 2008 Apr; 50(2):311-20. PMID: 18318038.
    Citations: 2     Fields:    Translation:Humans
  116. Heist RS, Zhai R, Liu G, Zhou W, Lin X, Su L, Asomaning K, Lynch TJ, Wain JC, Christiani DC. VEGF polymorphisms and survival in early-stage non-small-cell lung cancer. J Clin Oncol. 2008 Feb 20; 26(6):856-62. PMID: 18281657.
    Citations: 48     Fields:    Translation:Humans
  117. Harezlak J, Wu MC, Wang M, Schwartzman A, Christiani DC, Lin X. Biomarker discovery for arsenic exposure using functional data. Analysis and feature learning of mass spectrometry proteomic data. J Proteome Res. 2008 Jan; 7(1):217-24. PMID: 18173220.
    Citations: 8     Fields:    Translation:HumansPHPublic Health
  118. Lin X. Estimation using penalized quasilikelihood and quasi-pseudo-likelihood in Poisson mixed models. Lifetime Data Anal. 2007 Dec; 13(4):533-44. PMID: 18080833.
    Citations: 3     Fields:    Translation:Humans
  119. Harezlak J, Wang M, Christiani D, Lin X. Quantitative quality-assessment techniques to compare fractionation and depletion methods in SELDI-TOF mass spectrometry experiments. Bioinformatics. 2007 Sep 15; 23(18):2441-8. PMID: 17626063.
    Citations: 5     Fields:    Translation:Humans
  120. Su L, Zhou W, Asomaning K, Lin X, Wain JC, Lynch TJ, Liu G, Christiani DC. Genotypes and haplotypes of matrix metalloproteinase 1, 3 and 12 genes and the risk of lung cancer. Carcinogenesis. 2006 May; 27(5):1024-9. PMID: 16311244.
    Citations: 41     Fields:    Translation:Humans
  121. Li Y, Lin X. Testing the correlation for clustered categorical and censored discrete time-to-event data when covariates are measured without/with errors. Biometrics. 2003 Mar; 59(1):25-35. PMID: 12762438.
    Citations:    Fields:    Translation:HumansPHPublic Health
  122. Zhang D, Lin X. Hypothesis testing in semiparametric additive mixed models. Biostatistics. 2003 Jan; 4(1):57-74. PMID: 12925330.
    Citations: 64     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.