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Tianxi Cai, Sc.D.

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Overview

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01LM013614 (CAI, TIANXI) Aug 1, 2021 - Apr 30, 2025
    NIH
    Semi-supervised Approaches to Denoising Electronic Health Records Data for Risk Prediction
    Role: Principal Investigator
  2. R21AR078339 (LIAO, KATHERINE PHOENIX) Jul 1, 2021 - Jun 30, 2023
    NIH
    Studying exceptional treatment non-responders and genetics to predict treatment response in rheumatoid arthritis
    Role: Co-Principal Investigator
  3. R21CA242940 (CAI, TIANXI) Jul 1, 2019 - Jun 30, 2021
    NIH
    Semi-supervised Algorithms for Risk Assessment with Noisy EHR Data
    Role: Principal Investigator
  4. R01GM079330 (CAI, TIANXI) Jun 1, 2007 - Jun 30, 2016
    NIH
    Robust Approaches to the Development and Evaluation of Prognostic Classifiers
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Ahuja Y, Wen J, Hong C, Xia Z, Huang S, Cai T. A semi-supervised adaptive Markov Gaussian embedding process (SAMGEP) for prediction of phenotype event times using the electronic health record. Sci Rep. 2022 Oct 22; 12(1):17737. PMID: 36273240; PMCID: PMC9588081.
    Citations:    Fields:    Translation:Humans
  2. Nogues IE, Wen J, Lin Y, Liu M, Tedeschi SK, Geva A, Cai T, Hong C. Weakly Semi-supervised phenotyping using Electronic Health records. J Biomed Inform. 2022 10; 134:104175. PMID: 36064111.
    Citations:    Fields:    
  3. Han L, Wang X, Cai T. Identifying surrogate markers in real-world comparative effectiveness research. Stat Med. 2022 Nov 20; 41(26):5290-5304. PMID: 36062392.
    Citations:    Fields:    Translation:Humans
  4. Wang X, Zhang HG, Xiong X, Hong C, Weber GM, Brat GA, Bonzel CL, Luo Y, Duan R, Palmer NP, Hutch MR, Gutiérrez-Sacristán A, Bellazzi R, Chiovato L, Cho K, Dagliati A, Estiri H, García-Barrio N, Griffier R, Hanauer DA, Ho YL, Holmes JH, Keller MS, Klann MEng JG, L'Yi S, Lozano-Zahonero S, Maidlow SE, Makoudjou A, Malovini A, Moal B, Moore JH, Morris M, Mowery DL, Murphy SN, Neuraz A, Yuan Ngiam K, Omenn GS, Patel LP, Pedrera-Jiménez M, Prunotto A, Jebathilagam Samayamuthu M, Sanz Vidorreta FJ, Schriver ER, Schubert P, Serrano-Balazote P, South AM, Tan ALM, Tan BWL, Tibollo V, Tippmann P, Visweswaran S, Xia Z, Yuan W, Zöller D, Kohane IS, Avillach P, Guo Z, Cai T. SurvMaximin: Robust federated approach to transporting survival risk prediction models. J Biomed Inform. 2022 10; 134:104176. PMID: 36007785.
    Citations:    Fields:    Translation:Humans
  5. Cheng D, Kochar B, Cai T, Ritchie CS, Ananthakrishnan AN. Comorbidity Influences the Comparative Safety of Biologic Therapy in Older Adults With Inflammatory Bowel Diseases. Am J Gastroenterol. 2022 11 01; 117(11):1845-1850. PMID: 35854436; PMCID: PMC9633357.
    Citations:    Fields:    
  6. Zhang HG, Dagliati A, Shakeri Hossein Abad Z, Xiong X, Bonzel CL, Xia Z, Tan BWQ, Avillach P, Brat GA, Hong C, Morris M, Visweswaran S, Patel LP, Gutiérrez-Sacristán A, Hanauer DA, Holmes JH, Samayamuthu MJ, Bourgeois FT, L'Yi S, Maidlow SE, Moal B, Murphy SN, Strasser ZH, Neuraz A, Ngiam KY, Loh NHW, Omenn GS, Prunotto A, Dalvin LA, Klann JG, Schubert P, Vidorreta FJS, Benoit V, Verdy G, Kavuluru R, Estiri H, Luo Y, Malovini A, Tibollo V, Bellazzi R, Cho K, Ho YL, Tan ALM, Tan BWL, Gehlenborg N, Lozano-Zahonero S, Jouhet V, Chiovato L, Aronow BJ, Toh EMS, Wong WGS, Pizzimenti S, Wagholikar KB, Bucalo M, Cai T, South AM, Kohane IS, Weber GM. International electronic health record-derived post-acute sequelae profiles of COVID-19 patients. NPJ Digit Med. 2022 Jun 29; 5(1):81. PMID: 35768548; PMCID: PMC9242995.
    Citations:    
  7. Zhou QM, Wang X, Zheng Y, Cai T. New weighting methods when cases are only a subset of events in a nested case-control study. Biom J. 2022 10; 64(7):1240-1259. PMID: 35754309.
    Citations:    Fields:    
  8. Liang L, Hou J, Uno H, Cho K, Ma Y, Cai T. Semi-supervised approach to event time annotation using longitudinal electronic health records. Lifetime Data Anal. 2022 07; 28(3):428-491. PMID: 35753014.
    Citations:    Fields:    Translation:Humans
  9. Weber GM, Hong C, Xia Z, Palmer NP, Avillach P, L'Yi S, Keller MS, Murphy SN, Gutiérrez-Sacristán A, Bonzel CL, Serret-Larmande A, Neuraz A, Omenn GS, Visweswaran S, Klann JG, South AM, Loh NHW, Cannataro M, Beaulieu-Jones BK, Bellazzi R, Agapito G, Alessiani M, Aronow BJ, Bell DS, Benoit V, Bourgeois FT, Chiovato L, Cho K, Dagliati A, DuVall SL, Barrio NG, Hanauer DA, Ho YL, Holmes JH, Issitt RW, Liu M, Luo Y, Lynch KE, Maidlow SE, Malovini A, Mandl KD, Mao C, Matheny ME, Moore JH, Morris JS, Morris M, Mowery DL, Ngiam KY, Patel LP, Pedrera-Jimenez M, Ramoni RB, Schriver ER, Schubert P, Balazote PS, Spiridou A, Tan ALM, Tan BWL, Tibollo V, Torti C, Trecarichi EM, Wang X, Kohane IS, Cai T, Brat GA. International comparisons of laboratory values from the 4CE collaborative to predict COVID-19 mortality. NPJ Digit Med. 2022 Jun 13; 5(1):74. PMID: 35697747; PMCID: PMC9192605.
    Citations:    
  10. Cai T, He Z, Hong C, Zhang Y, Ho YL, Honerlaw J, Geva A, Ayakulangara Panickan V, King A, Gagnon DR, Gaziano M, Cho K, Liao K, Cai T. Scalable relevance ranking algorithm via semantic similarity assessment improves efficiency of medical chart review. J Biomed Inform. 2022 08; 132:104109. PMID: 35660521.
    Citations:    Fields:    
  11. Hou J, Zhao R, Cai T, Beaulieu-Jones B, Seyok T, Dahal K, Yuan Q, Xiong X, Bonzel CL, Fox C, Christiani DC, Jemielita T, Liao KP, Liaw KL, Cai T. Temporal Trends in Clinical Evidence of 5-Year Survival Within Electronic Health Records Among Patients With Early-Stage Colon Cancer Managed With Laparoscopy-Assisted Colectomy vs Open Colectomy. JAMA Netw Open. 2022 06 01; 5(6):e2218371. PMID: 35737384; PMCID: PMC9227003.
    Citations:    Fields:    Translation:Humans
  12. Zhu W, Tang X, Heyman RA, Cai T, Suh K, Seeger JD, Xia Z. Patterns of Utilization and Expenditure Across Multiple Sclerosis Disease-Modifying Therapies: A Retrospective Cohort Study Using Claims Data from a Commercially Insured Population in the United States, 2010-2019. Neurol Ther. 2022 Sep; 11(3):1147-1165. PMID: 35598225; PMCID: PMC9338211.
    Citations:    
  13. Galloway A, Park Y, Tanukonda V, Ho YL, Nguyen XT, Maripuri M, Dey AT, Gerlovin H, Posner D, Lynch KE, Cai T, Luoh SW, Whitbourne S, Gagnon DR, Muralidhar S, Tsao PS, Casas JP, Michael Gaziano J, Wilson PW, Hung AM, Cho K. Impact of COVID-19 Severity on Long-term Events in US Veterans using the Veterans Affairs Severity Index for COVID-19 (VASIC). J Infect Dis. 2022 May 05. PMID: 35512327; PMCID: PMC9129146.
    Citations:    Fields:    
  14. Gronsbell J, Liu M, Tian L, Cai T. Efficient Evaluation of Prediction Rules in Semi-Supervised Settings under Stratified Sampling. J R Stat Soc Series B Stat Methodol. 2022 Sep; 84(4):1353-1391. PMID: 36275859; PMCID: PMC9586151.
    Citations: 1     
  15. Wang X, Parast L, Han L, Tian L, Cai T. Robust approach to combining multiple markers to improve surrogacy. Biometrics. 2022 Apr 15. PMID: 35426444.
    Citations:    Fields:    
  16. Hong C, Wang Y, Cai T. A divide-and-conquer method for sparse risk prediction and evaluation. Biostatistics. 2022 04 13; 23(2):397-411. PMID: 32909599.
    Citations:    Fields:    Translation:Humans
  17. Link NB, Huang S, Cai T, Sun J, Dahal K, Costa L, Cho K, Liao K, Cai T, Hong C. Binary acronym disambiguation in clinical notes from electronic health records with an application in computational phenotyping. Int J Med Inform. 2022 Apr 01; 162:104753. PMID: 35405530.
    Citations:    Fields:    
  18. Ahuja Y, Liang L, Zhou D, Huang S, Cai T. Semisupervised Calibration of Risk with Noisy Event Times (SCORNET) using electronic health record data. Biostatistics. 2022 Feb 15. PMID: 35166342.
    Citations:    Fields:    
  19. Kochar BD, Cheng D, Cai T, Ananthakrishnan AN. Comparative Risk of Thrombotic and Cardiovascular Events with Tofacitinib and Anti-TNF Agents in Patients with Inflammatory Bowel Diseases. Dig Dis Sci. 2022 Nov; 67(11):5206-5212. PMID: 35113275.
    Citations:    Fields:    
  20. Cheng D, Kochar BD, Cai T, Ananthakrishnan AN. Risk of Infections With Ustekinumab and Tofacitinib Compared to Tumor Necrosis Factor a Antagonists in Inflammatory Bowel Diseases. Clin Gastroenterol Hepatol. 2022 10; 20(10):2366-2372.e6. PMID: 35066137; PMCID: PMC9296690.
    Citations: 1     Fields:    
  21. Zhang J, Can A, Lai PMR, Mukundan S, Castro VM, Dligach D, Finan S, Gainer VS, Shadick NA, Savova G, Murphy SN, Cai T, Weiss ST, Du R. Geometric Features Associated with Middle Cerebral Artery Bifurcation Aneurysm Formation: A Matched Case-Control Study. J Stroke Cerebrovasc Dis. 2022 Mar; 31(3):106268. PMID: 34974241.
    Citations:    Fields:    Translation:Humans
  22. Parast L, Cai T, Tian L. Testing for heterogeneity in the utility of a surrogate marker. Biometrics. 2021 Dec 07. PMID: 34874550; PMCID: PMC9170832.
    Citations:    Fields:    
  23. Weber GM, Zhang HG, L'Yi S, Bonzel CL, Hong C, Avillach P, Gutiérrez-Sacristán A, Palmer NP, Tan ALM, Wang X, Yuan W, Gehlenborg N, Alloni A, Amendola DF, Bellasi A, Bellazzi R, Beraghi M, Bucalo M, Chiovato L, Cho K, Dagliati A, Estiri H, Follett RW, García Barrio N, Hanauer DA, Henderson DW, Ho YL, Holmes JH, Hutch MR, Kavuluru R, Kirchoff K, Klann JG, Krishnamurthy AK, Le TT, Liu M, Loh NHW, Lozano-Zahonero S, Luo Y, Maidlow S, Makoudjou A, Malovini A, Martins MR, Moal B, Morris M, Mowery DL, Murphy SN, Neuraz A, Ngiam KY, Okoshi MP, Omenn GS, Patel LP, Pedrera Jiménez M, Prudente RA, Samayamuthu MJ, Sanz Vidorreta FJ, Schriver ER, Schubert P, Serrano Balazote P, Tan BW, Tanni SE, Tibollo V, Visweswaran S, Wagholikar KB, Xia Z, Zöller D, Kohane IS, Cai T, South AM, Brat GA. Authorship Correction: International Changes in COVID-19 Clinical Trajectories Across 315 Hospitals and 6 Countries: Retrospective Cohort Study. J Med Internet Res. 2021 Nov 30; 23(11):e34625. PMID: 34889759; PMCID: PMC8672293.
    Citations:    Fields:    
  24. Zhang HG, Hejblum BP, Weber GM, Palmer NP, Churchill SE, Szolovits P, Murphy SN, Liao KP, Kohane IS, Cai T. ATLAS: an automated association test using probabilistically linked health records with application to genetic studies. J Am Med Inform Assoc. 2021 11 25; 28(12):2582-2592. PMID: 34608931; PMCID: PMC8633652.
    Citations:    Fields:    Translation:Humans
  25. Park H, Gujrathi R, Gosangi B, Thomas R, Cai T, Chen I, Bay C, Hassan N, Boland G, Kohane I, Seltzer S, Rexrode K, Khurana B. Longitudinal imaging history in early identification of intimate partner violence. Eur Radiol. 2022 Apr; 32(4):2824-2836. PMID: 34797386.
    Citations:    Fields:    Translation:Humans
  26. Hou J, Chan SF, Wang X, Cai T. Risk prediction with imperfect survival outcome information from electronic health records. Biometrics. 2021 Nov 08. PMID: 34747010.
    Citations:    Fields:    
  27. Hou J, Kim N, Cai T, Dahal K, Weiner H, Chitnis T, Cai T, Xia Z. Comparison of Dimethyl Fumarate vs Fingolimod and Rituximab vs Natalizumab for Treatment of Multiple Sclerosis. JAMA Netw Open. 2021 11 01; 4(11):e2134627. PMID: 34783826; PMCID: PMC8596196.
    Citations: 4     Fields:    Translation:Humans
  28. Hong C, Rush E, Liu M, Zhou D, Sun J, Sonabend A, Castro VM, Schubert P, Panickan VA, Cai T, Costa L, He Z, Link N, Hauser R, Gaziano JM, Murphy SN, Ostrouchov G, Ho YL, Begoli E, Lu J, Cho K, Liao KP, Cai T. Clinical knowledge extraction via sparse embedding regression (KESER) with multi-center large scale electronic health record data. NPJ Digit Med. 2021 Oct 27; 4(1):151. PMID: 34707226; PMCID: PMC8551205.
    Citations: 2     
  29. Liang L, Kim N, Hou J, Cai T, Dahal K, Lin C, Finan S, Savovoa G, Rosso M, Polgar-Tucsanyi M, Weiner H, Chitnis T, Cai T, Xia Z. Temporal trends of multiple sclerosis disease activity: Electronic health records indicators. Mult Scler Relat Disord. 2022 Jan; 57:103333. PMID: 35158446; PMCID: PMC8849591.
    Citations:    Fields:    Translation:Humans
  30. Le TT, Gutiérrez-Sacristán A, Son J, Hong C, South AM, Beaulieu-Jones BK, Loh NHW, Luo Y, Morris M, Ngiam KY, Patel LP, Samayamuthu MJ, Schriver E, Tan ALM, Moore J, Cai T, Omenn GS, Avillach P, Kohane IS, Visweswaran S, Mowery DL, Xia Z. Multinational characterization of neurological phenotypes in patients hospitalized with COVID-19. Sci Rep. 2021 10 12; 11(1):20238. PMID: 34642371; PMCID: PMC8510999.
    Citations: 6     Fields:    Translation:HumansPHPublic Health
  31. Weber GM, Zhang HG, L'Yi S, Bonzel CL, Hong C, Avillach P, Gutiérrez-Sacristán A, Palmer NP, Tan ALM, Wang X, Yuan W, Gehlenborg N, Alloni A, Amendola DF, Bellasi A, Bellazzi R, Beraghi M, Bucalo M, Chiovato L, Cho K, Dagliati A, Estiri H, Follett RW, García Barrio N, Hanauer DA, Henderson DW, Ho YL, Holmes JH, Hutch MR, Kavuluru R, Kirchoff K, Klann JG, Krishnamurthy AK, Le TT, Liu M, Loh NHW, Lozano-Zahonero S, Luo Y, Maidlow S, Makoudjou A, Malovini A, Martins MR, Moal B, Morris M, Mowery DL, Murphy SN, Neuraz A, Ngiam KY, Okoshi MP, Omenn GS, Patel LP, Pedrera Jiménez M, Prudente RA, Samayamuthu MJ, Sanz Vidorreta FJ, Schriver ER, Schubert P, Serrano Balazote P, Tan BW, Tanni SE, Tibollo V, Visweswaran S, Wagholikar KB, Xia Z, Zöller D, Kohane IS, Cai T, South AM, Brat GA. International Changes in COVID-19 Clinical Trajectories Across 315 Hospitals and 6 Countries: Retrospective Cohort Study. J Med Internet Res. 2021 10 11; 23(10):e31400. PMID: 34533459; PMCID: PMC8510151.
    Citations: 5     Fields:    Translation:HumansCellsPHPublic Health
  32. Huang S, Cai T, Weber BN, He Z, Dahal KP, Hong C, Hou J, Seyok T, Cagan A, DiCarli MF, Joseph J, Kim SC, Solomon DH, Cai T, Liao KP. The Association Between Inflammation, Incident Heart Failure, and Heart Failure Subtypes in Patients with Rheumatoid Arthritis. Arthritis Care Res (Hoboken). 2021 Oct 08. PMID: 34623035; PMCID: PMC8989720.
    Citations:    Fields:    
  33. Wang X, Cai T, Tian L, Bourgeois F, Parast L. Quantifying the feasibility of shortening clinical trial duration using surrogate markers. Stat Med. 2021 12 10; 40(28):6321-6343. PMID: 34474500; PMCID: PMC8595715.
    Citations:    Fields:    Translation:Humans
  34. Cai T, Cai F, Dahal KP, Cremone G, Lam E, Golnik C, Seyok T, Hong C, Cai T, Liao KP. Improving the Efficiency of Clinical Trial Recruitment Using an Ensemble Machine Learning to Assist With Eligibility Screening. ACR Open Rheumatol. 2021 Sep; 3(9):593-600. PMID: 34296815.
    Citations: 1     
  35. Yuan Q, Cai T, Hong C, Du M, Johnson BE, Lanuti M, Cai T, Christiani DC. Performance of a Machine Learning Algorithm Using Electronic Health Record Data to Identify and Estimate Survival in a Longitudinal Cohort of Patients With Lung Cancer. JAMA Netw Open. 2021 07 01; 4(7):e2114723. PMID: 34232304.
    Citations: 5     Fields:    Translation:Humans
  36. Geva A, Liu M, Panickan VA, Avillach P, Cai T, Mandl KD. A high-throughput phenotyping algorithm is portable from adult to pediatric populations. J Am Med Inform Assoc. 2021 06 12; 28(6):1265-1269. PMID: 33594412; PMCID: PMC8661408.
    Citations: 1     Fields:    Translation:Humans
  37. Bourgeois FT, Gutiérrez-Sacristán A, Keller MS, Liu M, Hong C, Bonzel CL, Tan ALM, Aronow BJ, Boeker M, Booth J, Cruz Rojo J, Devkota B, García Barrio N, Gehlenborg N, Geva A, Hanauer DA, Hutch MR, Issitt RW, Klann JG, Luo Y, Mandl KD, Mao C, Moal B, Moshal KL, Murphy SN, Neuraz A, Ngiam KY, Omenn GS, Patel LP, Jiménez MP, Sebire NJ, Balazote PS, Serret-Larmande A, South AM, Spiridou A, Taylor DM, Tippmann P, Visweswaran S, Weber GM, Kohane IS, Cai T, Avillach P. International Analysis of Electronic Health Records of Children and Youth Hospitalized With COVID-19 Infection in 6 Countries. JAMA Netw Open. 2021 06 01; 4(6):e2112596. PMID: 34115127; PMCID: PMC8196345.
    Citations: 8     Fields:    Translation:HumansCellsPHPublic Health
  38. Wang X, Zheng Y, Jensen MK, He Z, Cai T. Biomarker evaluation under imperfect nested case-control design. Stat Med. 2021 08 15; 40(18):4035-4052. PMID: 33915597.
    Citations:    Fields:    Translation:Humans
  39. Wang Y, Hong C, Palmer N, Di Q, Schwartz J, Kohane I, Cai T. A fast divide-and-conquer sparse Cox regression. Biostatistics. 2021 04 10; 22(2):381-401. PMID: 31545341.
    Citations: 5     Fields:    Translation:Humans
  40. Kohane IS, Aronow BJ, Avillach P, Beaulieu-Jones BK, Bellazzi R, Bradford RL, Brat GA, Cannataro M, Cimino JJ, García-Barrio N, Gehlenborg N, Ghassemi M, Gutiérrez-Sacristán A, Hanauer DA, Holmes JH, Hong C, Klann JG, Loh NHW, Luo Y, Mandl KD, Daniar M, Moore JH, Murphy SN, Neuraz A, Ngiam KY, Omenn GS, Palmer N, Patel LP, Pedrera-Jiménez M, Sliz P, South AM, Tan ALM, Taylor DM, Taylor BW, Torti C, Vallejos AK, Wagholikar KB, Weber GM, Cai T. What Every Reader Should Know About Studies Using Electronic Health Record Data but May Be Afraid to Ask. J Med Internet Res. 2021 03 02; 23(3):e22219. PMID: 33600347; PMCID: PMC7927948.
    Citations: 9     Fields:    Translation:HumansCells
  41. Tedeschi SK, Cai T, He Z, Ahuja Y, Hong C, Yates KA, Dahal K, Xu C, Lyu H, Yoshida K, Solomon DH, Cai T, Liao KP. Classifying Pseudogout Using Machine Learning Approaches With Electronic Health Record Data. Arthritis Care Res (Hoboken). 2021 03; 73(3):442-448. PMID: 31910317; PMCID: PMC7338229.
    Citations: 2     Fields:    Translation:Humans
  42. Zhang J, Lai PMR, Can A, Mukundan S, Castro VM, Dligach D, Finan S, Gainer VS, Shadick NA, Savova G, Murphy SN, Cai T, Weiss ST, Du R. Tobacco use and age are associated with different morphologic features of anterior communicating artery aneurysms. Sci Rep. 2021 02 26; 11(1):4791. PMID: 33637879.
    Citations:    Fields:    Translation:Humans
  43. Chepelev LL, Wang X, Gold B, Bonzel CL, Rybicki F, Uyeda JW, Sheikh A, Anderson D, Lindaman J, Mogel G, Mitsouras D, Mahoney MC, Cai T, Rybicki FJ. Improved Appropriateness of Advanced Diagnostic Imaging After Implementation of Clinical Decision Support Mechanism. J Digit Imaging. 2021 04; 34(2):397-403. PMID: 33634414.
    Citations: 1     Fields:    Translation:Humans
  44. Ahuja Y, Kim N, Liang L, Cai T, Dahal K, Seyok T, Lin C, Finan S, Liao K, Savovoa G, Chitnis T, Cai T, Xia Z. Leveraging electronic health records data to predict multiple sclerosis disease activity. Ann Clin Transl Neurol. 2021 04; 8(4):800-810. PMID: 33626237.
    Citations: 4     Fields:    Translation:Humans
  45. Yuan W, Beaulieu-Jones BK, Yu KH, Lipnick SL, Palmer N, Loscalzo J, Cai T, Kohane IS. Temporal bias in case-control design: preventing reliable predictions of the future. Nat Commun. 2021 02 17; 12(1):1107. PMID: 33597541; PMCID: PMC7889612.
    Citations: 8     Fields:    Translation:Humans
  46. Weber GM, Hong C, Palmer NP, Avillach P, Murphy SN, Gutiérrez-Sacristán A, Xia Z, Serret-Larmande A, Neuraz A, Omenn GS, Visweswaran S, Klann JG, South AM, Loh NHW, Cannataro M, Beaulieu-Jones BK, Bellazzi R, Agapito G, Alessiani M, Aronow BJ, Bell DS, Bellasi A, Benoit V, Beraghi M, Boeker M, Booth J, Bosari S, Bourgeois FT, Brown NW, Bucalo M, Chiovato L, Chiudinelli L, Dagliati A, Devkota B, DuVall SL, Follett RW, Ganslandt T, García Barrio N, Gradinger T, Griffier R, Hanauer DA, Holmes JH, Horki P, Huling KM, Issitt RW, Jouhet V, Keller MS, Kraska D, Liu M, Luo Y, Lynch KE, Malovini A, Mandl KD, Mao C, Maram A, Matheny ME, Maulhardt T, Mazzitelli M, Milano M, Moore JH, Morris JS, Morris M, Mowery DL, Naughton TP, Ngiam KY, Norman JB, Patel LP, Pedrera Jimenez M, Ramoni RB, Schriver ER, Scudeller L, Sebire NJ, Serrano Balazote P, Spiridou A, Tan AL, Tan BW, Tibollo V, Torti C, Trecarichi EM, Vitacca M, Zambelli A, Zucco C, Kohane IS, Cai T, Brat GA. International Comparisons of Harmonized Laboratory Value Trajectories to Predict Severe COVID-19: Leveraging the 4CE Collaborative Across 342 Hospitals and 6 Countries: A Retrospective Cohort Study. medRxiv. 2021 Feb 05. PMID: 33564777; PMCID: PMC7872369.
    Citations:    
  47. Le TT, Gutiérrez-Sacristán A, Son J, Hong C, South AM, Beaulieu-Jones BK, Loh NHW, Luo Y, Morris M, Ngiam KY, Patel LP, Samayamuthu MJ, Schriver E, Tan AL, Moore J, Cai T, Omenn GS, Avillach P, Kohane IS, Visweswaran S, Mowery DL, Xia Z. Multinational Prevalence of Neurological Phenotypes in Patients Hospitalized with COVID-19. medRxiv. 2021 Jan 29. PMID: 33655281.
    Citations: 1     
  48. Zhang J, Can A, Lai PMR, Mukundan S, Castro VM, Dligach D, Finan S, Gainer VS, Shadick NA, Savova G, Murphy SN, Cai T, Weiss ST, Du R. Morphological variables associated with ruptured basilar tip aneurysms. Sci Rep. 2021 01 28; 11(1):2526. PMID: 33510194.
    Citations: 1     Fields:    Translation:Humans
  49. Zhang J, Can A, Lai PMR, Mukundan S, Castro VM, Dligach D, Finan S, Gainer V, Shadick N, Savova G, Murphy SN, Cai T, Weiss ST, Du R. Geometric variations associated with posterior communicating artery aneurysms. J Neurointerv Surg. 2021 Nov; 13(11):1049-1052. PMID: 33479035.
    Citations:    Fields:    Translation:Humans
  50. Zhang J, Can A, Lai PMR, Mukundan S, Castro VM, Dligach D, Finan S, Gainer VS, Shadick NA, Savova G, Murphy SN, Cai T, Weiss ST, Du R. Vascular Geometry Associated with Anterior Communicating Artery Aneurysm Formation. World Neurosurg. 2021 02; 146:e1318-e1325. PMID: 33307259; PMCID: PMC7897254.
    Citations: 2     Fields:    Translation:Humans
  51. Huang S, Huang J, Cai T, Dahal KP, Cagan A, He Z, Stratton J, Gorelik I, Hong C, Cai T, Liao KP. Impact of ICD10 and secular changes on electronic medical record rheumatoid arthritis algorithms. Rheumatology (Oxford). 2020 12 01; 59(12):3759-3766. PMID: 32413107; PMCID: PMC7733719.
    Citations: 5     Fields:    Translation:Humans
  52. Zhang J, Can A, Lai PMR, Mukundan S, Castro VM, Dligach D, Finan S, Gainer VS, Shadick NA, Savova G, Murphy SN, Cai T, Weiss ST, Du R. Surrounding vascular geometry associated with basilar tip aneurysm formation. Sci Rep. 2020 10 21; 10(1):17928. PMID: 33087795; PMCID: PMC7578056.
    Citations: 1     Fields:    Translation:Humans
  53. Parast L, Cai T, Tian L. Evaluating multiple surrogate markers with censored data. Biometrics. 2021 12; 77(4):1315-1327. PMID: 32920821; PMCID: PMC8162900.
    Citations:    Fields:    Translation:Humans
  54. Sacks FM, Liang L, Furtado JD, Cai T, Davidson WS, He Z, McClelland RL, Rimm EB, Jensen MK. Protein-Defined Subspecies of HDLs (High-Density Lipoproteins) and Differential Risk of Coronary Heart Disease in 4 Prospective Studies. Arterioscler Thromb Vasc Biol. 2020 11; 40(11):2714-2727. PMID: 32907368; PMCID: PMC7577984.
    Citations: 14     Fields:    Translation:Humans
  55. Brat GA, Weber GM, Gehlenborg N, Avillach P, Palmer NP, Chiovato L, Cimino J, Waitman LR, Omenn GS, Malovini A, Moore JH, Beaulieu-Jones BK, Tibollo V, Murphy SN, Yi SL, Keller MS, Bellazzi R, Hanauer DA, Serret-Larmande A, Gutierrez-Sacristan A, Holmes JJ, Bell DS, Mandl KD, Follett RW, Klann JG, Murad DA, Scudeller L, Bucalo M, Kirchoff K, Craig J, Obeid J, Jouhet V, Griffier R, Cossin S, Moal B, Patel LP, Bellasi A, Prokosch HU, Kraska D, Sliz P, Tan ALM, Ngiam KY, Zambelli A, Mowery DL, Schiver E, Devkota B, Bradford RL, Daniar M, Daniel C, Benoit V, Bey R, Paris N, Serre P, Orlova N, Dubiel J, Hilka M, Jannot AS, Breant S, Leblanc J, Griffon N, Burgun A, Bernaux M, Sandrin A, Salamanca E, Cormont S, Ganslandt T, Gradinger T, Champ J, Boeker M, Martel P, Esteve L, Gramfort A, Grisel O, Leprovost D, Moreau T, Varoquaux G, Vie JJ, Wassermann D, Mensch A, Caucheteux C, Haverkamp C, Lemaitre G, Bosari S, Krantz ID, South A, Cai T, Kohane IS. International electronic health record-derived COVID-19 clinical course profiles: the 4CE consortium. NPJ Digit Med. 2020; 3:109. PMID: 32864472.
    Citations: 55     
  56. Zhang T, Goodman M, Zhu F, Healy B, Carruthers R, Chitnis T, Weiner H, Cai T, De Jager P, Tremlett H, Xia Z. Phenome-wide examination of comorbidity burden and multiple sclerosis disease severity. Neurol Neuroimmunol Neuroinflamm. 2020 11; 7(6). PMID: 32817202; PMCID: PMC7673286.
    Citations: 6     Fields:    Translation:Humans
  57. Ahuja Y, Zhou D, He Z, Sun J, Castro VM, Gainer V, Murphy SN, Hong C, Cai T. sureLDA: A multidisease automated phenotyping method for the electronic health record. J Am Med Inform Assoc. 2020 08 01; 27(8):1235-1243. PMID: 32548637; PMCID: PMC7481024.
    Citations: 4     Fields:    Translation:Humans
  58. Zhang J, Can A, Lai PMR, Mukundan S, Castro VM, Dligach D, Finan S, Yu S, Gainer VS, Shadick NA, Savova G, Murphy SN, Cai T, Weiss ST, Du R. Age and morphology of posterior communicating artery aneurysms. Sci Rep. 2020 07 14; 10(1):11545. PMID: 32665589.
    Citations: 2     Fields:    Translation:Humans
  59. Chan S, Wang X, Jazic I, Peskoe S, Zheng Y, Cai T. Developing and evaluating risk prediction models with panel current status data. Biometrics. 2021 06; 77(2):599-609. PMID: 32562264.
    Citations:    Fields:    
  60. Koch M, DeKosky ST, Goodman M, Sun J, Furtado JD, Fitzpatrick AL, Mackey RH, Cai T, Lopez OL, Kuller LH, Mukamal KJ, Jensen MK. Association of Apolipoprotein E in Lipoprotein Subspecies With Risk of Dementia. JAMA Netw Open. 2020 07 01; 3(7):e209250. PMID: 32648923; PMCID: PMC7352155.
    Citations: 8     Fields:    Translation:Humans
  61. Cheng D, Ananthakrishnan AN, Cai T. Robust and efficient semi-supervised estimation of average treatment effects with application to electronic health records data. Biometrics. 2021 06; 77(2):413-423. PMID: 32413171; PMCID: PMC7758040.
    Citations:    Fields:    Translation:Humans
  62. Cheng D, Cushing KC, Cai T, Ananthakrishnan AN. Safety and Efficacy of Tumor Necrosis Factor Antagonists in Older Patients With Ulcerative Colitis: Patient-Level Pooled Analysis of Data From Randomized Trials. Clin Gastroenterol Hepatol. 2021 05; 19(5):939-946.e4. PMID: 32371165.
    Citations: 8     Fields:    Translation:Humans
  63. Zhao SS, Hong C, Cai T, Xu C, Huang J, Ermann J, Goodson NJ, Solomon DH, Cai T, Liao KP. Incorporating natural language processing to improve classification of axial spondyloarthritis using electronic health records. Rheumatology (Oxford). 2020 05 01; 59(5):1059-1065. PMID: 31535693; PMCID: PMC7850056.
    Citations: 4     Fields:    Translation:Humans
  64. Sonabend W A, Pellegrini AM, Chan S, Brown HE, Rosenquist JN, Vuijk PJ, Doyle AE, Perlis RH, Cai T. Integrating questionnaire measures for transdiagnostic psychiatric phenotyping using word2vec. PLoS One. 2020; 15(4):e0230663. PMID: 32243452.
    Citations: 1     Fields:    Translation:Humans
  65. Beam AL, Kompa B, Schmaltz A, Fried I, Weber G, Palmer N, Shi X, Cai T, Kohane IS. Clinical Concept Embeddings Learned from Massive Sources of Multimodal Medical Data. Pac Symp Biocomput. 2020; 25:295-306. PMID: 31797605.
    Citations: 28     Fields:    Translation:Humans
  66. Koch M, DeKosky ST, Goodman M, Sun J, Furtado JD, Fitzpatrick AL, Mackey RH, Cai T, Lopez OL, Kuller LH, Mukamal KJ, Jensen MK. High density lipoprotein and its apolipoprotein-defined subspecies and risk of dementia. J Lipid Res. 2020 03; 61(3):445-454. PMID: 31892526.
    Citations: 8     Fields:    Translation:Humans
  67. Wang X, Parast L, Tian LU, Cai T. Model-free approach to quantifying the proportion of treatment effect explained by a surrogate marker. Biometrika. 2020 Mar; 107(1):107-122. PMID: 32587413.
    Citations: 4     Fields:    
  68. Cheng D, Chakrabortty A, Ananthakrishnan AN, Cai T. Estimating average treatment effects with a double-index propensity score. Biometrics. 2020 09; 76(3):767-777. PMID: 31797368; PMCID: PMC7370895.
    Citations: 3     Fields:    Translation:Humans
  69. Zhang Y, Cai T, Yu S, Cho K, Hong C, Sun J, Huang J, Ho YL, Ananthakrishnan AN, Xia Z, Shaw SY, Gainer V, Castro V, Link N, Honerlaw J, Huang S, Gagnon D, Karlson EW, Plenge RM, Szolovits P, Savova G, Churchill S, O'Donnell C, Murphy SN, Gaziano JM, Kohane I, Cai T, Liao KP. High-throughput phenotyping with electronic medical record data using a common semi-supervised approach (PheCAP). Nat Protoc. 2019 12; 14(12):3426-3444. PMID: 31748751; PMCID: PMC7323894.
    Citations: 31     Fields:    Translation:Humans
  70. Cai T, Zhang L, Yang N, Kumamaru KK, Rybicki FJ, Cai T, Liao KP. EXTraction of EMR numerical data: an efficient and generalizable tool to EXTEND clinical research. BMC Med Inform Decis Mak. 2019 11 15; 19(1):226. PMID: 31730484; PMCID: PMC6858776.
    Citations: 3     Fields:    Translation:Humans
  71. Liao KP, Sun J, Cai TA, Link N, Hong C, Huang J, Huffman JE, Gronsbell J, Zhang Y, Ho YL, Castro V, Gainer V, Murphy SN, O'Donnell CJ, Gaziano JM, Cho K, Szolovits P, Kohane IS, Yu S, Cai T. High-throughput multimodal automated phenotyping (MAP) with application to PheWAS. J Am Med Inform Assoc. 2019 11 01; 26(11):1255-1262. PMID: 31613361.
    Citations: 19     Fields:    Translation:Humans
  72. Zhang L, Zhang Y, Cai T, Ahuja Y, He Z, Ho YL, Beam A, Cho K, Carroll R, Denny J, Kohane I, Liao K, Cai T. Automated grouping of medical codes via multiview banded spectral clustering. J Biomed Inform. 2019 12; 100:103322. PMID: 31672532.
    Citations: 3     Fields:    Translation:Humans
  73. Wang Y, Zhu J, Aroner S, Overvad K, Cai T, Yang M, Tjønneland A, Handberg A, Jensen MK. Plasma CD36 and Incident Diabetes: A Case-Cohort Study in Danish Men and Women. Diabetes Metab J. 2020 02; 44(1):134-142. PMID: 31701685.
    Citations: 2     Translation:Humans
  74. Ananthakrishnan AN, Cagan A, Cai T, Gainer VS, Savova G, Shaw SY, Churchill S, Burke KE, Karlson EW, Murphy SN, Kohane I, Liao KP, Xavier RJ. Use of Narrative Concepts in Electronic Health Records to Validate Associations Between Genetic Factors and Response to Treatment of Inflammatory Bowel Diseases. Clin Gastroenterol Hepatol. 2020 07; 18(8):1890-1892. PMID: 31404664.
    Citations: 1     Fields:    Translation:Humans
  75. Zhang J, Can A, Mukundan S, Steigner M, Castro VM, Dligach D, Finan S, Yu S, Gainer V, Shadick NA, Savova G, Murphy S, Cai T, Wang Z, Weiss ST, Du R. Morphological Variables Associated With Ruptured Middle Cerebral Artery Aneurysms. Neurosurgery. 2019 07 01; 85(1):75-83. PMID: 29850834.
    Citations: 7     Fields:    Translation:Humans
  76. Maziarz M, Cai T, Qi L, Lok AS, Zheng Y. Evaluating longitudinal markers under two-phase study designs. Biostatistics. 2019 07 01; 20(3):485-498. PMID: 29912281.
    Citations:    Fields:    Translation:Humans
  77. Parast L, Cai T, Tian L. Using a surrogate marker for early testing of a treatment effect. Biometrics. 2019 12; 75(4):1253-1263. PMID: 31009073.
    Citations: 1     Fields:    Translation:Humans
  78. Can A, Lai PMR, Castro VM, Yu S, Dligach D, Finan S, Gainer V, Shadick NA, Savova G, Murphy S, Cai T, Weiss ST, Du R. Decreased Total Iron Binding Capacity May Correlate with Ruptured Intracranial Aneurysms. Sci Rep. 2019 04 15; 9(1):6054. PMID: 30988354.
    Citations:    Fields:    Translation:Humans
  79. Parast L, Tian L, Cai T. Assessing the value of a censored surrogate outcome. Lifetime Data Anal. 2020 04; 26(2):245-265. PMID: 30980316.
    Citations: 2     Fields:    Translation:Humans
  80. Chan SF, Hejblum BP, Chakrabortty A, Cai T. Semi-supervised estimation of covariance with application to phenome-wide association studies with electronic medical records data. Stat Methods Med Res. 2020 02; 29(2):455-465. PMID: 30943854.
    Citations:    Fields:    
  81. Gronsbell J, Minnier J, Yu S, Liao K, Cai T. Automated feature selection of predictors in electronic medical records data. Biometrics. 2019 03; 75(1):268-277. PMID: 30353541.
    Citations: 8     Fields:    Translation:Humans
  82. Cai T, Cai TT, Liao K, Liu W. Large-Scale Simultaneous Testing of Cross-Covariance Matrices with Applications to PheWAS. Stat Sin. 2019 Apr; 29(2):983-1005. PMID: 31889766.
    Citations:    
  83. Hong C, Liao KP, Cai T. Semi-supervised validation of multiple surrogate outcomes with application to electronic medical records phenotyping. Biometrics. 2019 03; 75(1):78-89. PMID: 30267536.