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profileAllon Moshe Klein, PH.D.

TitleAssistant Professor of Systems Biology
InstitutionHarvard Medical School
DepartmentSystems Biology
AddressHarvard Medical School
Warren Alpert Bldg-WAB 536
200 Longwood Ave
Boston MA 02115
Phone617/432-5166
Fax617/432-6716
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R33CA212697     (KLEIN, ALLON MOSHE)Feb 16, 2017 - Jan 31, 2020
NIH/NCI
Droplet microfluidic technology for single cell cancer genomics
Role: Principal Investigator

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Wagner DE, Klein AM. Genetic screening enters the single-cell era. Nat Methods. 2017 Feb 28; 14(3):237-238. PMID: 28245215.
    View in: PubMed
  2. Zilionis R, Nainys J, Veres A, Savova V, Zemmour D, Klein AM, Mazutis L. Single-cell barcoding and sequencing using droplet microfluidics. Nat Protoc. 2017 Jan; 12(1):44-73. PMID: 27929523.
    View in: PubMed
  3. Baron M, Veres A, Wolock SL, Faust AL, Gaujoux R, Vetere A, Ryu JH, Wagner BK, Shen-Orr SS, Klein AM, Melton DA, Yanai I. A Single-Cell Transcriptomic Map of the Human and Mouse Pancreas Reveals Inter- and Intra-cell Population Structure. Cell Syst. 2016 Oct 26; 3(4):346-360.e4. PMID: 27667365.
    View in: PubMed
  4. Rompolas P, Mesa KR, Kawaguchi K, Park S, Gonzalez D, Brown S, Boucher J, Klein AM, Greco V. Spatiotemporal coordination of stem cell commitment during epidermal homeostasis. Science. 2016 Jun 17; 352(6292):1471-4. PMID: 27229141; PMCID: PMC4958018.
  5. Peshkin L, Wühr M, Pearl E, Haas W, Freeman RM, Gerhart JC, Klein AM, Horb M, Gygi SP, Kirschner MW. On the Relationship of Protein and mRNA Dynamics in Vertebrate Embryonic Development. Dev Cell. 2015 Nov 09; 35(3):383-94. PMID: 26555057; PMCID: PMC4776761 [Available on 11/09/16].
  6. Klein AM, Mazutis L, Akartuna I, Tallapragada N, Veres A, Li V, Peshkin L, Weitz DA, Kirschner MW. Droplet barcoding for single-cell transcriptomics applied to embryonic stem cells. Cell. 2015 May 21; 161(5):1187-201. PMID: 26000487; PMCID: PMC4441768.
  7. Lim X, Tan SH, Koh WL, Chau RM, Yan KS, Kuo CJ, van Amerongen R, Klein AM, Nusse R. Interfollicular epidermal stem cells self-renew via autocrine Wnt signaling. Science. 2013 Dec 06; 342(6163):1226-30. PMID: 24311688; PMCID: PMC4081860.
  8. Hernández AR, Klein AM, Kirschner MW. Kinetic responses of ß-catenin specify the sites of Wnt control. Science. 2012 Dec 07; 338(6112):1337-40. PMID: 23138978.
    View in: PubMed
  9. Doupé DP, Alcolea MP, Roshan A, Zhang G, Klein AM, Simons BD, Jones PH. A single progenitor population switches behavior to maintain and repair esophageal epithelium. Science. 2012 Aug 31; 337(6098):1091-3. PMID: 22821983; PMCID: PMC3527005.
  10. Klein AM, Lande-Diner L. The critical discussion group: fostering personal and scientific growth. Mol Cell. 2011 Oct 21; 44(2):167-9. PMID: 22017864.
    View in: PubMed
  11. Magenheim J, Klein AM, Stanger BZ, Ashery-Padan R, Sosa-Pineda B, Gu G, Dor Y. Ngn3(+) endocrine progenitor cells control the fate and morphogenesis of pancreatic ductal epithelium. Dev Biol. 2011 Nov 01; 359(1):26-36. PMID: 21888903; PMCID: PMC3746519.
  12. Klein AM, Simons BD. Universal patterns of stem cell fate in cycling adult tissues. Development. 2011 Aug; 138(15):3103-11. PMID: 21750026.
    View in: PubMed
  13. Waks Z, Klein AM, Silver PA. Cell-to-cell variability of alternative RNA splicing. Mol Syst Biol. 2011 Jul 05; 7:506. PMID: 21734645; PMCID: PMC3159976.
  14. Klein AM, Nikolaidou-Neokosmidou V, Doupé DP, Jones PH, Simons BD. Patterning as a signature of human epidermal stem cell regulation. J R Soc Interface. 2011 Dec 07; 8(65):1815-24. PMID: 21632613; PMCID: PMC3203489.
  15. Snippert HJ, van der Flier LG, Sato T, van Es JH, van den Born M, Kroon-Veenboer C, Barker N, Klein AM, van Rheenen J, Simons BD, Clevers H. Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells. Cell. 2010 Oct 01; 143(1):134-44. PMID: 20887898.
    View in: PubMed
  16. Salpeter SJ, Klein AM, Huangfu D, Grimsby J, Dor Y. Glucose and aging control the quiescence period that follows pancreatic beta cell replication. Development. 2010 Oct; 137(19):3205-13. PMID: 20823063; PMCID: PMC2934733.
  17. Lopez-Garcia C, Klein AM, Simons BD, Winton DJ. Intestinal stem cell replacement follows a pattern of neutral drift. Science. 2010 Nov 05; 330(6005):822-5. PMID: 20929733.
    View in: PubMed
  18. Klein AM, Nakagawa T, Ichikawa R, Yoshida S, Simons BD. Mouse germ line stem cells undergo rapid and stochastic turnover. Cell Stem Cell. 2010 Aug 06; 7(2):214-24. PMID: 20682447.
    View in: PubMed
  19. Doupé DP, Klein AM, Simons BD, Jones PH. The ordered architecture of murine ear epidermis is maintained by progenitor cells with random fate. Dev Cell. 2010 Feb 16; 18(2):317-23. PMID: 20159601.
    View in: PubMed
  20. Klein AM, Brash DE, Jones PH, Simons BD. Stochastic fate of p53-mutant epidermal progenitor cells is tilted toward proliferation by UV B during preneoplasia. Proc Natl Acad Sci U S A. 2010 Jan 05; 107(1):270-5. PMID: 20018764; PMCID: PMC2806764.
  21. Klein AM, Doupé DP, Jones PH, Simons BD. Mechanism of murine epidermal maintenance: cell division and the voter model. Phys Rev E Stat Nonlin Soft Matter Phys. 2008 Mar; 77(3 Pt 1):031907. PMID: 18517422.
    View in: PubMed
  22. Klein AM, Doupé DP, Jones PH, Simons BD. Kinetics of cell division in epidermal maintenance. Phys Rev E Stat Nonlin Soft Matter Phys. 2007 Aug; 76(2 Pt 1):021910. PMID: 17930068.
    View in: PubMed
  23. Clayton E, Doupé DP, Klein AM, Winton DJ, Simons BD, Jones PH. A single type of progenitor cell maintains normal epidermis. Nature. 2007 Mar 08; 446(7132):185-9. PMID: 17330052.
    View in: PubMed
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