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Allon Moshe Klein, PH.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01CA218579 (KLEIN, ALLON MOSHE) Jul 18, 2018 - Jun 30, 2023
    NIH/NCI
    Single Cell Genome-Wide Myeloid Response Profiling in Immunotherapy
    Role: Principal Investigator
  2. R01HL141402 (SOCOLOVSKY, MERAV) Apr 15, 2018 - Mar 31, 2022
    NIH/NHLBI
    Novel Growth Factor Regulators of Early Erythropoieisis
    Role: Co-Principal Investigator
  3. R33CA212697 (KLEIN, ALLON MOSHE) Feb 16, 2017 - Jan 31, 2020
    NIH/NCI
    Droplet microfluidic technology for single cell cancer genomics
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Mesa KR, Kawaguchi K, Cockburn K, Gonzalez D, Boucher J, Xin T, Klein AM, Greco V. Homeostatic Epidermal Stem Cell Self-Renewal Is Driven by Local Differentiation. Cell Stem Cell. 2018 Sep 24. PMID: 30269903.
    View in: PubMed
  2. Murai K, Skrupskelyte G, Piedrafita G, Hall M, Kostiou V, Ong SH, Nagy T, Cagan A, Goulding D, Klein AM, Hall BA, Jones PH. Epidermal Tissue Adapts to Restrain Progenitors Carrying Clonal p53 Mutations. Cell Stem Cell. 2018 Sep 20. PMID: 30269904.
    View in: PubMed
  3. DiSpirito JR, Zemmour D, Ramanan D, Cho J, Zilionis R, Klein AM, Benoist C, Mathis D. Molecular diversification of regulatory T cells in nonlymphoid tissues. Sci Immunol. 2018 Sep 14; 3(27). PMID: 30217811.
    View in: PubMed
  4. Plasschaert LW, Žilionis R, Choo-Wing R, Savova V, Knehr J, Roma G, Klein AM, Jaffe AB. A single-cell atlas of the airway epithelium reveals the CFTR-rich pulmonary ionocyte. Nature. 2018 Aug; 560(7718):377-381. PMID: 30069046.
    View in: PubMed
  5. Klein AM. Technique to measure the expression dynamics of each gene in a single cell. Nature. 2018 Aug; 560(7719):434-435. PMID: 30127477.
    View in: PubMed
  6. Hrvatin S, Hochbaum DR, Nagy MA, Cicconet M, Robertson K, Cheadle L, Zilionis R, Ratner A, Borges-Monroy R, Klein AM, Sabatini BL, Greenberg ME. Publisher Correction: Single-cell analysis of experience-dependent transcriptomic states in the mouse visual cortex. Nat Neurosci. 2018 Jul; 21(7):1017. PMID: 29752482.
    View in: PubMed
  7. Zemmour D, Zilionis R, Kiner E, Klein AM, Mathis D, Benoist C. Publisher Correction: Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR. Nat Immunol. 2018 Jun; 19(6):645. PMID: 29725080.
    View in: PubMed
  8. Wagner DE, Weinreb C, Collins ZM, Briggs JA, Megason SG, Klein AM. Single-cell mapping of gene expression landscapes and lineage in the zebrafish embryo. Science. 2018 06 01; 360(6392):981-987. PMID: 29700229.
    View in: PubMed
  9. Briggs JA, Weinreb C, Wagner DE, Megason S, Peshkin L, Kirschner MW, Klein AM. The dynamics of gene expression in vertebrate embryogenesis at single-cell resolution. Science. 2018 06 01; 360(6392). PMID: 29700227.
    View in: PubMed
  10. Weinreb C, Wolock S, Klein AM. SPRING: a kinetic interface for visualizing high dimensional single-cell expression data. Bioinformatics. 2018 04 01; 34(7):1246-1248. PMID: 29228172.
    View in: PubMed
  11. Raj B, Wagner DE, McKenna A, Pandey S, Klein AM, Shendure J, Gagnon JA, Schier AF. Simultaneous single-cell profiling of lineages and cell types in the vertebrate brain. Nat Biotechnol. 2018 Jun; 36(5):442-450. PMID: 29608178.
    View in: PubMed
  12. Tusi BK, Wolock SL, Weinreb C, Hwang Y, Hidalgo D, Zilionis R, Waisman A, Huh JR, Klein AM, Socolovsky M. Population snapshots predict early haematopoietic and erythroid hierarchies. Nature. 2018 03 01; 555(7694):54-60. PMID: 29466336.
    View in: PubMed
  13. Weinreb C, Wolock S, Tusi BK, Socolovsky M, Klein AM. Fundamental limits on dynamic inference from single-cell snapshots. Proc Natl Acad Sci U S A. 2018 03 06; 115(10):E2467-E2476. PMID: 29463712.
    View in: PubMed
  14. Zemmour D, Zilionis R, Kiner E, Klein AM, Mathis D, Benoist C. Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR. Nat Immunol. 2018 Mar; 19(3):291-301. PMID: 29434354.
    View in: PubMed
  15. Rodriguez-Fraticelli AE, Wolock SL, Weinreb CS, Panero R, Patel SH, Jankovic M, Sun J, Calogero RA, Klein AM, Camargo FD. Clonal analysis of lineage fate in native haematopoiesis. Nature. 2018 01 11; 553(7687):212-216. PMID: 29323290.
    View in: PubMed
  16. Hrvatin S, Hochbaum DR, Nagy MA, Cicconet M, Robertson K, Cheadle L, Zilionis R, Ratner A, Borges-Monroy R, Klein AM, Sabatini BL, Greenberg ME. Single-cell analysis of experience-dependent transcriptomic states in the mouse visual cortex. Nat Neurosci. 2018 Jan; 21(1):120-129. PMID: 29230054.
    View in: PubMed
  17. Presler M, Van Itallie E, Klein AM, Kunz R, Coughlin ML, Peshkin L, Gygi SP, Wühr M, Kirschner MW. Proteomics of phosphorylation and protein dynamics during fertilization and meiotic exit in the Xenopus egg. Proc Natl Acad Sci U S A. 2017 12 12; 114(50):E10838-E10847. PMID: 29183978.
    View in: PubMed
  18. Klein AM, Macosko E. InDrops and Drop-seq technologies for single-cell sequencing. Lab Chip. 2017 07 25; 17(15):2540-2541. PMID: 28721415.
    View in: PubMed
  19. Wagner DE, Klein AM. Genetic screening enters the single-cell era. Nat Methods. 2017 02 28; 14(3):237-238. PMID: 28245215.
    View in: PubMed
  20. Zilionis R, Nainys J, Veres A, Savova V, Zemmour D, Klein AM, Mazutis L. Single-cell barcoding and sequencing using droplet microfluidics. Nat Protoc. 2017 Jan; 12(1):44-73. PMID: 27929523.
    View in: PubMed
  21. Baron M, Veres A, Wolock SL, Faust AL, Gaujoux R, Vetere A, Ryu JH, Wagner BK, Shen-Orr SS, Klein AM, Melton DA, Yanai I. A Single-Cell Transcriptomic Map of the Human and Mouse Pancreas Reveals Inter- and Intra-cell Population Structure. Cell Syst. 2016 10 26; 3(4):346-360.e4. PMID: 27667365.
    View in: PubMed
  22. Rompolas P, Mesa KR, Kawaguchi K, Park S, Gonzalez D, Brown S, Boucher J, Klein AM, Greco V. Spatiotemporal coordination of stem cell commitment during epidermal homeostasis. Science. 2016 Jun 17; 352(6292):1471-4. PMID: 27229141; PMCID: PMC4958018.
  23. Peshkin L, Wühr M, Pearl E, Haas W, Freeman RM, Gerhart JC, Klein AM, Horb M, Gygi SP, Kirschner MW. On the Relationship of Protein and mRNA Dynamics in Vertebrate Embryonic Development. Dev Cell. 2015 Nov 09; 35(3):383-94. PMID: 26555057; PMCID: PMC4776761 [Available on 11/09/16].
  24. Klein AM, Mazutis L, Akartuna I, Tallapragada N, Veres A, Li V, Peshkin L, Weitz DA, Kirschner MW. Droplet barcoding for single-cell transcriptomics applied to embryonic stem cells. Cell. 2015 May 21; 161(5):1187-1201. PMID: 26000487; PMCID: PMC4441768.
  25. Lim X, Tan SH, Koh WL, Chau RM, Yan KS, Kuo CJ, van Amerongen R, Klein AM, Nusse R. Interfollicular epidermal stem cells self-renew via autocrine Wnt signaling. Science. 2013 Dec 06; 342(6163):1226-30. PMID: 24311688; PMCID: PMC4081860.
  26. Hernández AR, Klein AM, Kirschner MW. Kinetic responses of ß-catenin specify the sites of Wnt control. Science. 2012 Dec 07; 338(6112):1337-40. PMID: 23138978.
    View in: PubMed
  27. Doupé DP, Alcolea MP, Roshan A, Zhang G, Klein AM, Simons BD, Jones PH. A single progenitor population switches behavior to maintain and repair esophageal epithelium. Science. 2012 Aug 31; 337(6098):1091-3. PMID: 22821983.
    View in: PubMed
  28. Klein AM, Lande-Diner L. The critical discussion group: fostering personal and scientific growth. Mol Cell. 2011 Oct 21; 44(2):167-9. PMID: 22017864.
    View in: PubMed
  29. Magenheim J, Klein AM, Stanger BZ, Ashery-Padan R, Sosa-Pineda B, Gu G, Dor Y. Ngn3(+) endocrine progenitor cells control the fate and morphogenesis of pancreatic ductal epithelium. Dev Biol. 2011 Nov 01; 359(1):26-36. PMID: 21888903; PMCID: PMC3746519.
  30. Klein AM, Simons BD. Universal patterns of stem cell fate in cycling adult tissues. Development. 2011 Aug; 138(15):3103-11. PMID: 21750026.
    View in: PubMed
  31. Waks Z, Klein AM, Silver PA. Cell-to-cell variability of alternative RNA splicing. Mol Syst Biol. 2011 Jul 05; 7:506. PMID: 21734645; PMCID: PMC3159976.
  32. Klein AM, Nikolaidou-Neokosmidou V, Doupé DP, Jones PH, Simons BD. Patterning as a signature of human epidermal stem cell regulation. J R Soc Interface. 2011 Dec 07; 8(65):1815-24. PMID: 21632613; PMCID: PMC3203489.
  33. Snippert HJ, van der Flier LG, Sato T, van Es JH, van den Born M, Kroon-Veenboer C, Barker N, Klein AM, van Rheenen J, Simons BD, Clevers H. Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells. Cell. 2010 Oct 01; 143(1):134-44. PMID: 20887898.
    View in: PubMed
  34. Salpeter SJ, Klein AM, Huangfu D, Grimsby J, Dor Y. Glucose and aging control the quiescence period that follows pancreatic beta cell replication. Development. 2010 Oct; 137(19):3205-13. PMID: 20823063; PMCID: PMC2934733.
  35. Lopez-Garcia C, Klein AM, Simons BD, Winton DJ. Intestinal stem cell replacement follows a pattern of neutral drift. Science. 2010 Nov 05; 330(6005):822-5. PMID: 20929733.
    View in: PubMed
  36. Klein AM, Nakagawa T, Ichikawa R, Yoshida S, Simons BD. Mouse germ line stem cells undergo rapid and stochastic turnover. Cell Stem Cell. 2010 Aug 06; 7(2):214-24. PMID: 20682447.
    View in: PubMed
  37. Doupé DP, Klein AM, Simons BD, Jones PH. The ordered architecture of murine ear epidermis is maintained by progenitor cells with random fate. Dev Cell. 2010 Feb 16; 18(2):317-23. PMID: 20159601.
    View in: PubMed
  38. Klein AM, Brash DE, Jones PH, Simons BD. Stochastic fate of p53-mutant epidermal progenitor cells is tilted toward proliferation by UV B during preneoplasia. Proc Natl Acad Sci U S A. 2010 Jan 05; 107(1):270-5. PMID: 20018764; PMCID: PMC2806764.
  39. Klein AM, Doupé DP, Jones PH, Simons BD. Mechanism of murine epidermal maintenance: cell division and the voter model. Phys Rev E Stat Nonlin Soft Matter Phys. 2008 Mar; 77(3 Pt 1):031907. PMID: 18517422.
    View in: PubMed
  40. Klein AM, Doupé DP, Jones PH, Simons BD. Kinetics of cell division in epidermal maintenance. Phys Rev E Stat Nonlin Soft Matter Phys. 2007 Aug; 76(2 Pt 1):021910. PMID: 17930068.
    View in: PubMed
  41. Clayton E, Doupé DP, Klein AM, Winton DJ, Simons BD, Jones PH. A single type of progenitor cell maintains normal epidermis. Nature. 2007 Mar 08; 446(7132):185-9. PMID: 17330052.
    View in: PubMed
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