Harvard Catalyst Profiles

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Marcia C. Haigis, Ph.D.

Title
Institution
Department
Address

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01CA213062 (HAIGIS, MARCIA) Jun 1, 2017 - May 31, 2022
    NIH/NCI
    Molecular mechanisms of Nutrient sensing in cancer
    Role: Principal Investigator
  2. R01DK103295 (HAIGIS, MARCIA) Mar 1, 2015 - Feb 28, 2019
    NIH/NIDDK
    Control of metabolic homeostasis in diabetes by sirtuins
    Role: Principal Investigator
  3. R01AG032375 (HAIGIS, MARCIA) Sep 15, 2009 - Aug 31, 2015
    NIH/NIA
    Regulation of mitochondrial metabolism by SIRT4
    Role: Principal Investigator
  4. F32AG022775 (HAIGIS, MARCIA C) Jul 18, 2003 - Jul 17, 2006
    NIH/NIA
    Role of Sirt4 in aging
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Ron-Harel N, Notarangelo G, Ghergurovich JM, Paulo JA, Sage PT, Santos D, Satterstrom FK, Gygi SP, Rabinowitz JD, Sharpe AH, Haigis MC. Defective respiration and one-carbon metabolism contribute to impaired naïve T cell activation in aged mice. Proc Natl Acad Sci U S A. 2018 12 26; 115(52):13347-13352. PMID: 30530686.
    Citations:    Fields:    
  2. Ringel AE, Tucker SA, Haigis MC. Chemical and Physiological Features of Mitochondrial Acylation. Mol Cell. 2018 Nov 15; 72(4):610-624. PMID: 30444998.
    Citations:    Fields:    
  3. McBrayer SK, Mayers JR, DiNatale GJ, Shi DD, Khanal J, Chakraborty AA, Sarosiek KA, Briggs KJ, Robbins AK, Sewastianik T, Shareef SJ, Olenchock BA, Parker SJ, Tateishi K, Spinelli JB, Islam M, Haigis MC, Looper RE, Ligon KL, Bernstein BE, Carrasco RD, Cahill DP, Asara JM, Metallo CM, Yennawar NH, Vander Heiden MG, Kaelin WG. Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma. Cell. 2018 Sep 20; 175(1):101-116.e25. PMID: 30220459.
    Citations:    
  4. Adachi Y, De Sousa-Coelho AL, Harata I, Aoun C, Weimer S, Shi X, Gonzalez Herrera KN, Takahashi H, Doherty C, Noguchi Y, Goodyear LJ, Haigis MC, Gerszten RE, Patti ME. l-Alanine activates hepatic AMP-activated protein kinase and modulates systemic glucose metabolism. Mol Metab. 2018 Nov; 17:61-70. PMID: 30190193.
    Citations:    Fields:    
  5. Mills EL, Pierce KA, Jedrychowski MP, Garrity R, Winther S, Vidoni S, Yoneshiro T, Spinelli JB, Lu GZ, Kazak L, Banks AS, Haigis MC, Kajimura S, Murphy MP, Gygi SP, Clish CB, Chouchani ET. Accumulation of succinate controls activation of adipose tissue thermogenesis. Nature. 2018 08; 560(7716):102-106. PMID: 30022159.
    Citations: 2     Fields:    Translation:AnimalsCells
  6. Spinelli JB, Haigis MC. The multifaceted contributions of mitochondria to cellular metabolism. Nat Cell Biol. 2018 Jul; 20(7):745-754. PMID: 29950572.
    Citations: 3     Fields:    
  7. Lee JJ, van de Ven RAH, Zaganjor E, Ng MR, Barakat A, Demmers JJPG, Finley LWS, Gonzalez Herrera KN, Hung YP, Harris IS, Jeong SM, Danuser G, McAllister SS, Haigis MC. Inhibition of epithelial cell migration and Src/FAK signaling by SIRT3. Proc Natl Acad Sci U S A. 2018 07 03; 115(27):7057-7062. PMID: 29915029.
    Citations:    Fields:    Translation:HumansCells
  8. Escudero S, Zaganjor E, Lee S, Mill CP, Morgan AM, Crawford EB, Chen J, Wales TE, Mourtada R, Luccarelli J, Bird GH, Steidl U, Engen JR, Haigis MC, Opferman JT, Walensky LD. Dynamic Regulation of Long-Chain Fatty Acid Oxidation by a Noncanonical Interaction between the MCL-1 BH3 Helix and VLCAD. Mol Cell. 2018 03 01; 69(5):729-743.e7. PMID: 29499131.
    Citations: 1     Fields:    Translation:AnimalsCells
  9. Gonzalez Herrera KN, Zaganjor E, Ishikawa Y, Spinelli JB, Yoon H, Lin JR, Satterstrom FK, Ringel A, Mulei S, Souza A, Gorham JM, Benson CC, Seidman JG, Sorger PK, Clish CB, Haigis MC. Small-Molecule Screen Identifies De Novo Nucleotide Synthesis as a Vulnerability of Cells Lacking SIRT3. Cell Rep. 2018 02 20; 22(8):1945-1955. PMID: 29466723.
    Citations:    Fields:    
  10. Spinelli JB, Yoon H, Ringel AE, Jeanfavre S, Clish CB, Haigis MC. Metabolic recycling of ammonia via glutamate dehydrogenase supports breast cancer biomass. Science. 2017 11 17; 358(6365):941-946. PMID: 29025995.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  11. Malone CF, Emerson C, Ingraham R, Barbosa W, Guerra S, Yoon H, Liu LL, Michor F, Haigis M, Macleod KF, Maertens O, Cichowski K. mTOR and HDAC Inhibitors Converge on the TXNIP/Thioredoxin Pathway to Cause Catastrophic Oxidative Stress and Regression of RAS-Driven Tumors. Cancer Discov. 2017 12; 7(12):1450-1463. PMID: 28963352.
    Citations: 1     Fields:    Translation:HumansCells
  12. Spinelli JB, Kelley LP, Haigis MC. An LC-MS Approach to Quantitative Measurement of Ammonia Isotopologues. Sci Rep. 2017 Sep 04; 7(1):10304. PMID: 28871132.
    Citations: 1     Fields:    
  13. Zaganjor E, Spinelli JB, Haigis MC. Strength in numbers: Phosphofructokinase polymerization prevails in the liver. J Cell Biol. 2017 08 07; 216(8):2239-2241. PMID: 28716843.
    Citations: 2     Fields:    Translation:Cells
  14. Zaganjor E, Vyas S, Haigis MC. SIRT4 Is a Regulator of Insulin Secretion. Cell Chem Biol. 2017 Jun 22; 24(6):656-658. PMID: 28644956.
    Citations:    Fields:    Translation:Animals
  15. van de Ven RAH, Santos D, Haigis MC. Mitochondrial Sirtuins and Molecular Mechanisms of Aging. Trends Mol Med. 2017 04; 23(4):320-331. PMID: 28285806.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  16. Yang W, Nagasawa K, Münch C, Xu Y, Satterstrom K, Jeong S, Hayes SD, Jedrychowski MP, Vyas FS, Zaganjor E, Guarani V, Ringel AE, Gygi SP, Harper JW, Haigis MC. Mitochondrial Sirtuin Network Reveals Dynamic SIRT3-Dependent Deacetylation in Response to Membrane Depolarization. Cell. 2016 11 03; 167(4):985-1000.e21. PMID: 27881304.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  17. Sage PT, Ron-Harel N, Juneja VR, Sen DR, Maleri S, Sungnak W, Kuchroo VK, Haining WN, Chevrier N, Haigis M, Sharpe AH. Suppression by TFR cells leads to durable and selective inhibition of B cell effector function. Nat Immunol. 2016 Dec; 17(12):1436-1446. PMID: 27695002.
    Citations: 31     Fields:    Translation:AnimalsCells
  18. German NJ, Yoon H, Yusuf RZ, Murphy JP, Finley LW, Laurent G, Haas W, Satterstrom FK, Guarnerio J, Zaganjor E, Santos D, Pandolfi PP, Beck AH, Gygi SP, Scadden DT, Kaelin WG, Haigis MC. PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2. Mol Cell. 2016 09 15; 63(6):1006-20. PMID: 27635760.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  19. Vyas S, Zaganjor E, Haigis MC. Mitochondria and Cancer. Cell. 2016 Jul 28; 166(3):555-566. PMID: 27471965.
    Citations: 71     Fields:    Translation:HumansAnimalsCells
  20. Ron-Harel N, Santos D, Ghergurovich JM, Sage PT, Reddy A, Lovitch SB, Dephoure N, Satterstrom FK, Sheffer M, Spinelli JB, Gygi S, Rabinowitz JD, Sharpe AH, Haigis MC. Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation. Cell Metab. 2016 07 12; 24(1):104-17. PMID: 27411012.
    Citations: 27     Fields:    Translation:AnimalsCells
  21. Jeong SM, Haigis MC. Sirtuins in Cancer: a Balancing Act between Genome Stability and Metabolism. Mol Cells. 2015 Sep; 38(9):750-8. PMID: 26420294.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  22. Sage PT, Tan CL, Freeman GJ, Haigis M, Sharpe AH. Defective TFH Cell Function and Increased TFR Cells Contribute to Defective Antibody Production in Aging. Cell Rep. 2015 Jul 14; 12(2):163-71. PMID: 26146074; PMCID: PMC4504745.
    Citations: 16     Fields:    Translation:AnimalsCells
  23. German NJ, Haigis MC. Sirtuins and the Metabolic Hurdles in Cancer. Curr Biol. 2015 Jun 29; 25(13):R569-83. PMID: 26126285.
    Citations: 10     Fields:    Translation:HumansCells
  24. Satterstrom FK, Swindell WR, Laurent G, Vyas S, Bulyk ML, Haigis MC. Nuclear respiratory factor 2 induces SIRT3 expression. Aging Cell. 2015 Oct; 14(5):818-25. PMID: 26109058.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  25. Gonzalez Herrera KN, Lee J, Haigis MC. Intersections between mitochondrial sirtuin signaling and tumor cell metabolism. Crit Rev Biochem Mol Biol. 2015; 50(3):242-55. PMID: 25898275.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  26. Ron-Harel N, Sharpe AH, Haigis MC. Mitochondrial metabolism in T cell activation and senescence: a mini-review. Gerontology. 2015; 61(2):131-8. PMID: 25402204.
    Citations: 6     Fields:    Translation:HumansCells
  27. LeBleu VS, O'Connell JT, Herrera KN, Wikman H, Pantel K, Haigis MC, de Carvalho FM, Damascena A, Chinen LT, Rocha RM, Asara JM, Kalluri R. Corrigendum: PGC-1a mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis. Nat Cell Biol. 2014 Oct 31; 16(11):1125. PMID: 25358352.
    Citations:    
  28. LeBleu VS, O'Connell JT, Gonzalez Herrera KN, Wikman H, Pantel K, Haigis MC, de Carvalho FM, Damascena A, Domingos Chinen LT, Rocha RM, Asara JM, Kalluri R. PGC-1a mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis. Nat Cell Biol. 2014 Oct; 16(10):992-1003, 1-15. PMID: 25241037; PMCID: PMC4369153.
    Citations: 188     Fields:    Translation:HumansAnimalsCells
  29. Janzer A, German NJ, Gonzalez-Herrera KN, Asara JM, Haigis MC, Struhl K. Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells. Proc Natl Acad Sci U S A. 2014 Jul 22; 111(29):10574-9. PMID: 25002509; PMCID: PMC4115496.
    Citations: 75     Fields:    Translation:HumansCells
  30. Sinkevicius KW, Kriegel C, Bellaria KJ, Lee J, Lau AN, Leeman KT, Zhou P, Beede AM, Fillmore CM, Caswell D, Barrios J, Wong KK, Sholl LM, Schlaeger TM, Bronson RT, Chirieac LR, Winslow MM, Haigis MC, Kim CF. Neurotrophin receptor TrkB promotes lung adenocarcinoma metastasis. Proc Natl Acad Sci U S A. 2014 Jul 15; 111(28):10299-304. PMID: 24982195; PMCID: PMC4104911.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  31. Jeong SM, Lee J, Finley LW, Schmidt PJ, Fleming MD, Haigis MC. SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron regulatory protein 1. Oncogene. 2015 Apr 16; 34(16):2115-24. PMID: 24909164; PMCID: PMC4747239.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  32. Satterstrom FK, Haigis MC. Luciferase-based reporter to monitor the transcriptional activity of the SIRT3 promoter. Methods Enzymol. 2014; 543:141-63. PMID: 24924131.
    Citations: 3     Fields:    Translation:HumansCells
  33. Jeong SM, Lee A, Lee J, Haigis MC. SIRT4 protein suppresses tumor formation in genetic models of Myc-induced B cell lymphoma. J Biol Chem. 2014 Feb 14; 289(7):4135-44. PMID: 24368766; PMCID: PMC3924279.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  34. Bause AS, Matsui MS, Haigis MC. The protein deacetylase SIRT3 prevents oxidative stress-induced keratinocyte differentiation. J Biol Chem. 2013 Dec 20; 288(51):36484-91. PMID: 24194516; PMCID: PMC3868761.
    Citations: 10     Fields:    Translation:HumansCells
  35. Laurent G, de Boer VC, Finley LW, Sweeney M, Lu H, Schug TT, Cen Y, Jeong SM, Li X, Sauve AA, Haigis MC. SIRT4 represses peroxisome proliferator-activated receptor a activity to suppress hepatic fat oxidation. Mol Cell Biol. 2013 Nov; 33(22):4552-61. PMID: 24043310; PMCID: PMC3838178.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  36. Laurent G, German NJ, Saha AK, de Boer VC, Davies M, Koves TR, Dephoure N, Fischer F, Boanca G, Vaitheesvaran B, Lovitch SB, Sharpe AH, Kurland IJ, Steegborn C, Gygi SP, Muoio DM, Ruderman NB, Haigis MC. SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase. Mol Cell. 2013 Jun 06; 50(5):686-98. PMID: 23746352; PMCID: PMC3721068.
    Citations: 72     Fields:    Translation:AnimalsCells
  37. Yang MH, Laurent G, Bause AS, Spang R, German N, Haigis MC, Haigis KM. HDAC6 and SIRT2 regulate the acetylation state and oncogenic activity of mutant K-RAS. Mol Cancer Res. 2013 Sep; 11(9):1072-7. PMID: 23723075; PMCID: PMC3778089.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  38. Csibi A, Fendt SM, Li C, Poulogiannis G, Choo AY, Chapski DJ, Jeong SM, Dempsey JM, Parkhitko A, Morrison T, Henske EP, Haigis MC, Cantley LC, Stephanopoulos G, Yu J, Blenis J. The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4. Cell. 2013 May 09; 153(4):840-54. PMID: 23663782; PMCID: PMC3684628.
    Citations: 135     Fields:    Translation:HumansAnimalsCells
  39. Jeong SM, Xiao C, Finley LW, Lahusen T, Souza AL, Pierce K, Li YH, Wang X, Laurent G, German NJ, Xu X, Li C, Wang RH, Lee J, Csibi A, Cerione R, Blenis J, Clish CB, Kimmelman A, Deng CX, Haigis MC. SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism. Cancer Cell. 2013 Apr 15; 23(4):450-63. PMID: 23562301; PMCID: PMC3650305.
    Citations: 102     Fields:    Translation:HumansAnimalsCells
  40. Son J, Lyssiotis CA, Ying H, Wang X, Hua S, Ligorio M, Perera RM, Ferrone CR, Mullarky E, Shyh-Chang N, Kang Y, Fleming JB, Bardeesy N, Asara JM, Haigis MC, DePinho RA, Cantley LC, Kimmelman AC. Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway. Nature. 2013 Apr 04; 496(7443):101-5. PMID: 23535601; PMCID: PMC3656466.
    Citations: 373     Fields:    Translation:HumansCells
  41. Lee PC, Dodart JC, Aron L, Finley LW, Bronson RT, Haigis MC, Yankner BA, Harper JW. Altered social behavior and neuronal development in mice lacking the Uba6-Use1 ubiquitin transfer system. Mol Cell. 2013 Apr 25; 50(2):172-84. PMID: 23499007; PMCID: PMC3640669.
    Citations: 8     Fields:    Translation:AnimalsCells
  42. Peserico A, Chiacchiera F, Grossi V, Matrone A, Latorre D, Simonatto M, Fusella A, Ryall JG, Finley LW, Haigis MC, Villani G, Puri PL, Sartorelli V, Simone C. A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels. Cell Mol Life Sci. 2013 Jun; 70(11):2015-29. PMID: 23283301.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  43. Sebastián C, Satterstrom FK, Haigis MC, Mostoslavsky R. From sirtuin biology to human diseases: an update. J Biol Chem. 2012 Dec 14; 287(51):42444-52. PMID: 23086954; PMCID: PMC3522245.
    Citations: 57     Fields:    Translation:Humans
  44. Bause AS, Haigis MC. SIRT3 regulation of mitochondrial oxidative stress. Exp Gerontol. 2013 Jul; 48(7):634-9. PMID: 22964489.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  45. Carracedo A, Weiss D, Leliaert AK, Bhasin M, de Boer VC, Laurent G, Adams AC, Sundvall M, Song SJ, Ito K, Finley LS, Egia A, Libermann T, Gerhart-Hines Z, Puigserver P, Haigis MC, Maratos-Flier E, Richardson AL, Schafer ZT, Pandolfi PP. A metabolic prosurvival role for PML in breast cancer. J Clin Invest. 2012 Sep; 122(9):3088-100. PMID: 22886304; PMCID: PMC3433768.
    Citations: 68     Fields:    Translation:HumansAnimalsCells
  46. Inuzuka H, Gao D, Finley LW, Yang W, Wan L, Fukushima H, Chin YR, Zhai B, Shaik S, Lau AW, Wang Z, Gygi SP, Nakayama K, Teruya-Feldstein J, Toker A, Haigis MC, Pandolfi PP, Wei W. Acetylation-dependent regulation of Skp2 function. Cell. 2012 Jul 06; 150(1):179-93. PMID: 22770219; PMCID: PMC3595190.
    Citations: 65     Fields:    Translation:HumansAnimalsCells
  47. Finley LW, Haigis MC. Metabolic regulation by SIRT3: implications for tumorigenesis. Trends Mol Med. 2012 Sep; 18(9):516-23. PMID: 22749020; PMCID: PMC4765807.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  48. Yang MH, Nickerson S, Kim ET, Liot C, Laurent G, Spang R, Philips MR, Shan Y, Shaw DE, Bar-Sagi D, Haigis MC, Haigis KM. Regulation of RAS oncogenicity by acetylation. Proc Natl Acad Sci U S A. 2012 Jul 03; 109(27):10843-8. PMID: 22711838; PMCID: PMC3390846.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  49. Haigis MC, Deng CX, Finley LW, Kim HS, Gius D. SIRT3 is a mitochondrial tumor suppressor: a scientific tale that connects aberrant cellular ROS, the Warburg effect, and carcinogenesis. Cancer Res. 2012 May 15; 72(10):2468-72. PMID: 22589271; PMCID: PMC3354726.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  50. Cerletti M, Jang YC, Finley LW, Haigis MC, Wagers AJ. Short-term calorie restriction enhances skeletal muscle stem cell function. Cell Stem Cell. 2012 May 04; 10(5):515-9. PMID: 22560075; PMCID: PMC3561899.
    Citations: 81     Fields:    Translation:AnimalsCells
  51. Garcia-Cao I, Song MS, Hobbs RM, Laurent G, Giorgi C, de Boer VC, Anastasiou D, Ito K, Sasaki AT, Rameh L, Carracedo A, Vander Heiden MG, Cantley LC, Pinton P, Haigis MC, Pandolfi PP. Systemic elevation of PTEN induces a tumor-suppressive metabolic state. Cell. 2012 Mar 30; 149(1):49-62. PMID: 22401813; PMCID: PMC3319228.
    Citations: 109     Fields:    Translation:AnimalsCells
  52. Finley LW, Lee J, Souza A, Desquiret-Dumas V, Bullock K, Rowe GC, Procaccio V, Clish CB, Arany Z, Haigis MC. Skeletal muscle transcriptional coactivator PGC-1a mediates mitochondrial, but not metabolic, changes during calorie restriction. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):2931-6. PMID: 22308395; PMCID: PMC3286952.
    Citations: 33     Fields:    Translation:AnimalsCells
  53. De Raedt T, Walton Z, Yecies JL, Li D, Chen Y, Malone CF, Maertens O, Jeong SM, Bronson RT, Lebleu V, Kalluri R, Normant E, Haigis MC, Manning BD, Wong KK, Macleod KF, Cichowski K. Exploiting cancer cell vulnerabilities to develop a combination therapy for ras-driven tumors. Cancer Cell. 2011 Sep 13; 20(3):400-13. PMID: 21907929.
    Citations: 88     Fields:    Translation:AnimalsCells
  54. Finley LW, Haas W, Desquiret-Dumas V, Wallace DC, Procaccio V, Gygi SP, Haigis MC. Succinate dehydrogenase is a direct target of sirtuin 3 deacetylase activity. PLoS One. 2011; 6(8):e23295. PMID: 21858060; PMCID: PMC3157345.
    Citations: 90     Fields:    Translation:HumansAnimalsCells
  55. Yang S, Wang X, Contino G, Liesa M, Sahin E, Ying H, Bause A, Li Y, Stommel JM, Dell'antonio G, Mautner J, Tonon G, Haigis M, Shirihai OS, Doglioni C, Bardeesy N, Kimmelman AC. Pancreatic cancers require autophagy for tumor growth. Genes Dev. 2011 Apr 01; 25(7):717-29. PMID: 21406549; PMCID: PMC3070934.
    Citations: 365     Fields:    Translation:HumansAnimalsCells
  56. Finley LW, Carracedo A, Lee J, Souza A, Egia A, Zhang J, Teruya-Feldstein J, Moreira PI, Cardoso SM, Clish CB, Pandolfi PP, Haigis MC. SIRT3 opposes reprogramming of cancer cell metabolism through HIF1a destabilization. Cancer Cell. 2011 Mar 08; 19(3):416-28. PMID: 21397863; PMCID: PMC3065720.
    Citations: 234     Fields:    Translation:HumansAnimalsCells
  57. Srivastava S, Haigis MC. Role of sirtuins and calorie restriction in neuroprotection: implications in Alzheimer's and Parkinson's diseases. Curr Pharm Des. 2011; 17(31):3418-33. PMID: 21902666.
    Citations: 27     Fields:    Translation:Humans
  58. Haigis MC, Yankner BA. The aging stress response. Mol Cell. 2010 Oct 22; 40(2):333-44. PMID: 20965426; PMCID: PMC2987618.
    Citations: 132     Fields:    Translation:HumansAnimalsCells
  59. Verdin E, Hirschey MD, Finley LW, Haigis MC. Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling. Trends Biochem Sci. 2010 Dec; 35(12):669-75. PMID: 20863707; PMCID: PMC2992946.
    Citations: 143     Fields:    Translation:HumansAnimalsCells
  60. Haigis MC, Sinclair DA. Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol. 2010; 5:253-95. PMID: 20078221; PMCID: PMC2866163.
    Citations: 537     Fields:    Translation:HumansAnimals
  61. Lomb DJ, Laurent G, Haigis MC. Sirtuins regulate key aspects of lipid metabolism. Biochim Biophys Acta. 2010 Aug; 1804(8):1652-7. PMID: 19962456.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  62. Nakagawa T, Lomb DJ, Haigis MC, Guarente L. SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle. Cell. 2009 May 01; 137(3):560-70. PMID: 19410549; PMCID: PMC2698666.
    Citations: 209     Fields:    Translation:HumansAnimalsCells
  63. Finley LW, Haigis MC. The coordination of nuclear and mitochondrial communication during aging and calorie restriction. Ageing Res Rev. 2009 Jul; 8(3):173-88. PMID: 19491041; PMCID: PMC4702504.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  64. Haigis KM, Kendall KR, Wang Y, Cheung A, Haigis MC, Glickman JN, Niwa-Kawakita M, Sweet-Cordero A, Sebolt-Leopold J, Shannon KM, Settleman J, Giovannini M, Jacks T. Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon. Nat Genet. 2008 May; 40(5):600-8. PMID: 18372904; PMCID: PMC2410301.
    Citations: 209     Fields:    Translation:HumansAnimalsCells
  65. Lombard DB, Alt FW, Cheng HL, Bunkenborg J, Streeper RS, Mostoslavsky R, Kim J, Yancopoulos G, Valenzuela D, Murphy A, Yang Y, Chen Y, Hirschey MD, Bronson RT, Haigis M, Guarente LP, Farese RV, Weissman S, Verdin E, Schwer B. Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol Cell Biol. 2007 Dec; 27(24):8807-14. PMID: 17923681; PMCID: PMC2169418.
    Citations: 394     Fields:    Translation:AnimalsCells
  66. Haigis MC, Guarente LP. Mammalian sirtuins--emerging roles in physiology, aging, and calorie restriction. Genes Dev. 2006 Nov 01; 20(21):2913-21. PMID: 17079682.
    Citations: 400     Fields:    Translation:HumansAnimalsCells
  67. Haigis MC, Mostoslavsky R, Haigis KM, Fahie K, Christodoulou DC, Murphy AJ, Valenzuela DM, Yancopoulos GD, Karow M, Blander G, Wolberger C, Prolla TA, Weindruch R, Alt FW, Guarente L. SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell. 2006 Sep 08; 126(5):941-54. PMID: 16959573.
    Citations: 323     Fields:    Translation:HumansAnimalsCells
  68. Blander G, Olejnik J, Krzymanska-Olejnik E, McDonagh T, Haigis M, Yaffe MB, Guarente L. SIRT1 shows no substrate specificity in vitro. J Biol Chem. 2005 Mar 18; 280(11):9780-5. PMID: 15640142.
    Citations: 26     Fields:    Translation:HumansCells
  69. Dickson KA, Haigis MC, Raines RT. Ribonuclease inhibitor: structure and function. Prog Nucleic Acid Res Mol Biol. 2005; 80:349-74. PMID: 16164979; PMCID: PMC2811166.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  70. Leissring MA, Farris W, Wu X, Christodoulou DC, Haigis MC, Guarente L, Selkoe DJ. Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria. Biochem J. 2004 Nov 01; 383(Pt. 3):439-46. PMID: 15285718; PMCID: PMC1133736.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  71. Lin SJ, Ford E, Haigis M, Liszt G, Guarente L. Calorie restriction extends yeast life span by lowering the level of NADH. Genes Dev. 2004 Jan 01; 18(1):12-6. PMID: 14724176; PMCID: PMC314267.
    Citations: 201     Fields:    Translation:AnimalsCells
  72. Blander G, de Oliveira RM, Conboy CM, Haigis M, Guarente L. Superoxide dismutase 1 knock-down induces senescence in human fibroblasts. J Biol Chem. 2003 Oct 03; 278(40):38966-9. PMID: 12871978.
    Citations: 37     Fields:    Translation:HumansCells
  73. Haigis MC, Kurten EL, Raines RT. Ribonuclease inhibitor as an intracellular sentry. Nucleic Acids Res. 2003 Feb 01; 31(3):1024-32. PMID: 12560499; PMCID: PMC149185.
    Citations: 49     Fields:    Translation:HumansCells
  74. Haigis MC, Raines RT. Secretory ribonucleases are internalized by a dynamin-independent endocytic pathway. J Cell Sci. 2003 Jan 15; 116(Pt 2):313-24. PMID: 12482917; PMCID: PMC2812863.
    Citations: 30     Fields:    Translation:HumansCells
  75. Abel RL, Haigis MC, Park C, Raines RT. Fluorescence assay for the binding of ribonuclease A to the ribonuclease inhibitor protein. Anal Biochem. 2002 Jul 01; 306(1):100-7. PMID: 12069420.
    Citations: 13     Fields:    Translation:Cells
  76. Haigis MC, Haag ES, Raines RT. Evolution of ribonuclease inhibitor by exon duplication. Mol Biol Evol. 2002 Jun; 19(6):959-63. PMID: 12032252.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  77. Umezawa N, Gelman MA, Haigis MC, Raines RT, Gellman SH. Translocation of a beta-peptide across cell membranes. J Am Chem Soc. 2002 Jan 23; 124(3):368-9. PMID: 11792194.
    Citations: 29     Fields:    Translation:HumansCells
  78. Haigis MC, Kurten EL, Abel RL, Raines RT. KFERQ sequence in ribonuclease A-mediated cytotoxicity. J Biol Chem. 2002 Mar 29; 277(13):11576-81. PMID: 11801605.
    Citations: 11     Fields:    Translation:HumansCells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.