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Lois Elaine Hodgson Smith, M.D., Ph.D.

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Overview
Lois Smith MD, PhD, has been Professor of Ophthalmology since 2007. Dr. Smith's research accomplishments include the development and standardization of the mouse model of oxygen-induced retinopathy; basic mechanisms of vascular growth and translation to the clinic via VEGF; growth hormone and insulin-like growth factor in retinopathy; the role of omega-3 and omega-6 polyunsaturated fatty acids and other lipids in photoreceptor metabolism driving angiogenesis; and photoreceptor energy deficiency as cause of neovascular AMD. Dr. Smith's notable recent accomplishments include development of mitochondrial functional mapping of the retina and optic nerve; development of FGF21 as a treatment for diseases with depressed mitochondrial function, including retinal degenerations (retinitis pigmentosa), AMD, diabetic retinopathy, and ROP; the development of GPR40 and GPR120 as targets for improving mitochondrial function in disease; and SOCS3 as a modulator of inflammation in photoreceptor signaling.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01EY030904 (SMITH, LOIS) Jan 1, 2020 - Dec 31, 2023
    NIH/NEI
    Glucose/lipid metabolism and vessel development in phase I ROP
    Role: Principal Investigator
  2. 5R24EY024868-04 (SMITH, LOIS) Apr 1, 2015 - Mar 31, 2019
    NIH/NEI
    Novel therapies to inhibit diabetic retinopathy
    Role Description: This award will fund studies that will coordinate bench research with clinical trials of LCPUFA and cyclooxygenase inhibition in retinopathy
    Role: PI
  3. R01EY022275 (SMITH, LOIS) May 1, 2012 - Apr 30, 2015
    NIH/NEI
    Neuronal guidance molecules control revascularization in retinopathy
    Role: Principal Investigator
  4. (SMITH, LOIS) Apr 1, 2007 - Mar 31, 2019
    Alcon Laboratories, Inc.
    Alcon Research Institute Award
    Role: PI
  5. R01EY017017 (SMITH, LOIS) Jul 1, 2006 - Jun 30, 2016
    NIH/NEI
    Dietary control of angiogenesis in retinopathy models
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Tomita Y, Cakir B, Liu CH, Fu Z, Huang S, Cho SS, Britton WR, Sun Y, Puder M, Hellström A, Talukdar S, Smith LEH. Free fatty acid receptor 4 activation protects against choroidal neovascularization in mice. Angiogenesis. 2020 Mar 05. PMID: 32140799.
    Citations:    
  2. Yanagida K, Engelbrecht E, Niaudet C, Jung B, Gaengel K, Holton K, Swendeman S, Liu CH, Levesque MV, Kuo A, Fu Z, Smith LEH, Betsholtz C, Hla T. Sphingosine 1-Phosphate Receptor Signaling Establishes AP-1 Gradients to Allow for Retinal Endothelial Cell Specialization. Dev Cell. 2020 Mar 23; 52(6):779-793.e7. PMID: 32059774.
    Citations:    
  3. Tomita Y, Fu Z, Wang Z, Cakir B, Cho SS, Britton W, Sun Y, Hellström A, Talukdar S, Smith LEH. Long-Acting FGF21 Inhibits Retinal Vascular Leakage in In Vivo and In Vitro Models. Int J Mol Sci. 2020 Feb 11; 21(4). PMID: 32054022.
    Citations:    
  4. Pivodic A, Hård AL, Löfqvist C, Smith LEH, Wu C, Bründer MC, Lagrèze WA, Stahl A, Holmström G, Albertsson-Wikland K, Johansson H, Nilsson S, Hellström A. Individual Risk Prediction for Sight-Threatening Retinopathy of Prematurity Using Birth Characteristics. JAMA Ophthalmol. 2019 Nov 07; 1-9. PMID: 31697330.
    Citations:    
  5. Kern TS, Antonetti DA, Smith LEH. Pathophysiology of Diabetic Retinopathy: Contribution and Limitations of Laboratory Research. Ophthalmic Res. 2019; 62(4):196-202. PMID: 31362288.
    Citations:    
  6. Lundgren P, Klevebro S, Brodin P, Smith LEH, Hallberg B, Hellström A. Leucocytosis is associated with retinopathy of prematurity in extremely preterm infants. Acta Paediatr. 2019 07; 108(7):1357-1358. PMID: 30920014.
    Citations:    
  7. Hellström A, Hård AL, Smith LEH. Tailored vs Static Oxygen Saturation Targets to Prevent Retinopathy of Prematurity. JAMA Ophthalmol. 2019 04 01; 137(4):423-424. PMID: 30763437.
    Citations:    
  8. Smith LEH, Hellström A, Stahl A, Fielder A, Chambers W, Moseley J, Toth C, Wallace D, Darlow BA, Aranda JV, Hallberg B, Davis JM. Development of a Retinopathy of Prematurity Activity Scale and Clinical Outcome Measures for Use in Clinical Trials. JAMA Ophthalmol. 2019 03 01; 137(3):305-311. PMID: 30543348.
    Citations:    Fields:    
  9. Hård AL, Nilsson AK, Lund AM, Hansen-Pupp I, Smith LEH, Hellström A. Review shows that donor milk does not promote the growth and development of preterm infants as well as maternal milk. Acta Paediatr. 2019 06; 108(6):998-1007. PMID: 30565323.
    Citations:    Fields:    
  10. Bichsel CA, Goss J, Alomari M, Alexandrescu S, Robb R, Smith LE, Hochman M, Greene AK, Bischoff J. Association of Somatic GNAQ Mutation With Capillary Malformations in a Case of Choroidal Hemangioma. JAMA Ophthalmol. 2019 01 01; 137(1):91-95. PMID: 30422215.
    Citations:    Fields:    
  11. Ley D, Hallberg B, Hansen-Pupp I, Dani C, Ramenghi LA, Marlow N, Beardsall K, Bhatti F, Dunger D, Higginson JD, Mahaveer A, Mezu-Ndubuisi OJ, Reynolds P, Giannantonio C, van Weissenbruch M, Barton N, Tocoian A, Hamdani M, Jochim E, Mangili A, Chung JK, Turner MA, Smith LEH, Hellström A. rhIGF-1/rhIGFBP-3 in Preterm Infants: A Phase 2 Randomized Controlled Trial. J Pediatr. 2019 03; 206:56-65.e8. PMID: 30471715.
    Citations:    Fields:    
  12. Lundgren P, Hellgren G, Pivodic A, Sävman K, Smith LEH, Hellström A. Erythropoietin serum levels, versus anaemia as risk factors for severe retinopathy of prematurity. Pediatr Res. 2019 08; 86(2):276-282. PMID: 30297879.
    Citations:    Fields:    
  13. Sun Y, Smith LEH. Retinal Vasculature in Development and Diseases. Annu Rev Vis Sci. 2018 09 15; 4:101-122. PMID: 30222533.
    Citations:    Fields:    
  14. Wallace DK, Dean TW, Hartnett ME, Kong L, Smith LE, Hubbard GB, McGregor ML, Jordan CO, Mantagos IS, Bell EF, Kraker RT. A Dosing Study of Bevacizumab for Retinopathy of Prematurity: Late Recurrences and Additional Treatments. Ophthalmology. 2018 12; 125(12):1961-1966. PMID: 29887334.
    Citations:    Fields:    
  15. Nilsson AK, Löfqvist C, Najm S, Hellgren G, Sävman K, Andersson MX, Smith LEH, Hellström A. Influence of Human Milk and Parenteral Lipid Emulsions on Serum Fatty Acid Profiles in Extremely Preterm Infants. JPEN J Parenter Enteral Nutr. 2019 01; 43(1):152-161. PMID: 29679529.
    Citations:    Fields:    
  16. Sveinsdóttir K, Ley D, Hövel H, Fellman V, Hüppi PS, Smith LEH, Hellström A, Hansen Pupp I. Relation of Retinopathy of Prematurity to Brain Volumes at Term Equivalent Age and Developmental Outcome at 2 Years of Corrected Age in Very Preterm Infants. Neonatology. 2018; 114(1):46-52. PMID: 29649829.
    Citations:    Fields:    
  17. Nilsson AK, Löfqvist C, Najm S, Hellgren G, Sävman K, Andersson MX, Smith LEH, Hellström A. Long-chain polyunsaturated fatty acids decline rapidly in milk from mothers delivering extremely preterm indicating the need for supplementation. Acta Paediatr. 2018 06; 107(6):1020-1027. PMID: 29444356.
    Citations:    Fields:    
  18. Löfqvist CA, Najm S, Hellgren G, Engström E, Sävman K, Nilsson AK, Andersson MX, Hård AL, Smith LEH, Hellström A. Association of Retinopathy of Prematurity With Low Levels of Arachidonic Acid: A Secondary Analysis of a Randomized Clinical Trial. JAMA Ophthalmol. 2018 03 01; 136(3):271-277. PMID: 29423508.
    Citations:    Fields:    
  19. Stahl A, Krohne TU, Eter N, Oberacher-Velten I, Guthoff R, Meltendorf S, Ehrt O, Aisenbrey S, Roider J, Gerding H, Jandeck C, Smith LEH, Walz JM. Comparing Alternative Ranibizumab Dosages for Safety and Efficacy in Retinopathy of Prematurity: A Randomized Clinical Trial. JAMA Pediatr. 2018 03 01; 172(3):278-286. PMID: 29309486.
    Citations:    
  20. Fu Z, Wang Z, Liu CH, Gong Y, Cakir B, Liegl R, Sun Y, Meng SS, Burnim SB, Arellano I, Moran E, Duran R, Poblete A, Cho SS, Talukdar S, Akula JD, Hellström A, Smith LEH. Fibroblast Growth Factor 21 Protects Photoreceptor Function in Type 1 Diabetic Mice. Diabetes. 2018 05; 67(5):974-985. PMID: 29487115.
    Citations:    Fields:    Translation:AnimalsCells
  21. Pearsall EA, Cheng R, Zhou K, Takahashi Y, Matlock HG, Vadvalkar SS, Shin Y, Fredrick TW, Gantner ML, Meng S, Fu Z, Gong Y, Kinter M, Humphries KM, Szweda LI, Smith LEH, Ma JX. PPARa is essential for retinal lipid metabolism and neuronal survival. BMC Biol. 2017 Nov 28; 15(1):113. PMID: 29183319.
    Citations: 1     Fields:    Translation:AnimalsCells
  22. Hellgren G, Löfqvist C, Hansen-Pupp I, Gram M, Smith LE, Ley D, Hellström A. Increased postnatal concentrations of pro-inflammatory cytokines are associated with reduced IGF-I levels and retinopathy of prematurity. Growth Horm IGF Res. 2018 04; 39:19-24. PMID: 29274846.
    Citations:    Fields:    Translation:Humans
  23. Lundgren P, Hård AL, Wilde Å, Löfqvist C, Smith LEH, Hellström A. Implementing higher oxygen saturation targets reduced the impact of poor weight gain as a predictor for retinopathy of prematurity. Acta Paediatr. 2018 05; 107(5):767-773. PMID: 28872709.
    Citations:    Fields:    
  24. Chen J, Fu Y, Day DS, Sun Y, Wang S, Liang X, Gu F, Zhang F, Stevens SM, Zhou P, Li K, Zhang Y, Lin RZ, Smith LEH, Zhang J, Sun K, Melero-Martin JM, Han Z, Park PJ, Zhang B, Pu WT. VEGF amplifies transcription through ETS1 acetylation to enable angiogenesis. Nat Commun. 2017 08 29; 8(1):383. PMID: 28851877.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  25. Fu Z, Liegl R, Wang Z, Gong Y, Liu CH, Sun Y, Cakir B, Burnim SB, Meng SS, Löfqvist C, SanGiovanni JP, Hellström A, Smith LEH. Adiponectin Mediates Dietary Omega-3 Long-Chain Polyunsaturated Fatty Acid Protection Against Choroidal Neovascularization in Mice. Invest Ophthalmol Vis Sci. 2017 08 01; 58(10):3862-3870. PMID: 28763559.
    Citations:    Fields:    Translation:AnimalsCells
  26. Agyemang AA, Sveinsdóttir K, Vallius S, Sveinsdóttir S, Bruschettini M, Romantsik O, Hellström A, Smith LEH, Ohlsson L, Holmqvist B, Gram M, Ley D. Cerebellar Exposure to Cell-Free Hemoglobin Following Preterm Intraventricular Hemorrhage: Causal in Cerebellar Damage? Transl Stroke Res. 2017 Jun 10. PMID: 28601919.
    Citations: 1     Fields:    
  27. Wallace DK, Kraker RT, Freedman SF, Crouch ER, Hutchinson AK, Bhatt AR, Rogers DL, Yang MB, Haider KM, VanderVeen DK, Siatkowski RM, Dean TW, Beck RW, Repka MX, Smith LE, Good WV, Hartnett ME, Kong L, Holmes JM. Assessment of Lower Doses of Intravitreous Bevacizumab for Retinopathy of Prematurity: A Phase 1 Dosing Study. JAMA Ophthalmol. 2017 06 01; 135(6):654-656. PMID: 28448664.
    Citations: 9     Fields:    Translation:HumansCTClinical Trials
  28. Najm S, Löfqvist C, Hellgren G, Engström E, Lundgren P, Hård AL, Lapillonne A, Sävman K, Nilsson AK, Andersson MX, Smith LEH, Hellström A. Effects of a lipid emulsion containing fish oil on polyunsaturated fatty acid profiles, growth and morbidities in extremely premature infants: A randomized controlled trial. Clin Nutr ESPEN. 2017 Aug; 20:17-23. PMID: 29072164.
    Citations: 4     Fields:    Translation:Humans
  29. Sun Y, Lin Z, Liu CH, Gong Y, Liegl R, Fredrick TW, Meng SS, Burnim SB, Wang Z, Akula JD, Pu WT, Chen J, Smith LEH. Inflammatory signals from photoreceptor modulate pathological retinal angiogenesis via c-Fos. J Exp Med. 2017 06 05; 214(6):1753-1767. PMID: 28465464.
    Citations: 3     Fields:    Translation:AnimalsCells
  30. Levin LA, Miller JW, Zack DJ, Friedlander M, Smith LEH. Special Commentary: Early Clinical Development of Cell Replacement Therapy: Considerations for the National Eye Institute Audacious Goals Initiative. Ophthalmology. 2017 07; 124(7):926-934. PMID: 28365209.
    Citations: 1     Fields:    Translation:HumansAnimals
  31. Sun Y, Liegl R, Gong Y, Bühler A, Cakir B, Meng SS, Burnim SB, Liu CH, Reuer T, Zhang P, Walz JM, Ludwig F, Lange C, Agostini H, Böhringer D, Schlunck G, Smith LEH, Stahl A. Sema3f Protects Against Subretinal Neovascularization In Vivo. EBioMedicine. 2017 Apr; 18:281-287. PMID: 28373097.
    Citations: 2     Fields:    Translation:Animals
  32. Fu Z, Gong Y, Liegl R, Wang Z, Liu CH, Meng SS, Burnim SB, Saba NJ, Fredrick TW, Morss PC, Hellstrom A, Talukdar S, Smith LE. FGF21 Administration Suppresses Retinal and Choroidal Neovascularization in Mice. Cell Rep. 2017 02 14; 18(7):1606-1613. PMID: 28199833.
    Citations: 1     Fields:    Translation:Animals
  33. Hellstrom A, Ley D, Hallberg B, Lofqvist C, Hansen-Pupp I, Ramenghi LA, Borg J, Smith LEH, Hard AL. IGF-1 as a Drug for Preterm Infants: A Step-Wise Clinical Development. Curr Pharm Des. 2017; 23(38):5964-5970. PMID: 28969546.
    Citations:    Fields:    
  34. Gong Y, Shao Z, Fu Z, Edin ML, Sun Y, Liegl RG, Wang Z, Liu CH, Burnim SB, Meng SS, Lih FB, SanGiovanni JP, Zeldin DC, Hellström A, Smith LEH. Fenofibrate Inhibits Cytochrome P450 Epoxygenase 2C Activity to Suppress Pathological Ocular Angiogenesis. EBioMedicine. 2016 Nov; 13:201-211. PMID: 27720395.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  35. Hellström A, Ley D, Hansen-Pupp I, Hallberg B, Ramenghi LA, Löfqvist C, Smith LE, Hård AL. IGF-I in the clinics: Use in retinopathy of prematurity. Growth Horm IGF Res. 2016 Oct - Dec; 30-31:75-80. PMID: 27720550.
    Citations: 3     Fields:    Translation:Humans
  36. Liegl R, Löfqvist C, Hellström A, Smith LE. IGF-1 in retinopathy of prematurity, a CNS neurovascular disease. Early Hum Dev. 2016 11; 102:13-19. PMID: 27650433.
    Citations: 2     Fields:    Translation:Humans
  37. Lundgren P, Lundberg L, Hellgren G, Holmström G, Hård AL, Smith LE, Wallin A, Hallberg B, Hellström A. Aggressive Posterior Retinopathy of Prematurity Is Associated with Multiple Infectious Episodes and Thrombocytopenia. Neonatology. 2017; 111(1):79-85. PMID: 27631399.
    Citations: 4     Fields:    Translation:Humans
  38. Hellström A, Ley D, Hansen-Pupp I, Hallberg B, Ramenghi LA, Löfqvist C, Smith LE, Hård AL. Role of Insulinlike Growth Factor 1 in Fetal Development and in the Early Postnatal Life of Premature Infants. Am J Perinatol. 2016 09; 33(11):1067-71. PMID: 27603537.
    Citations: 4     Fields:    Translation:Humans
  39. Moran EP, Wang Z, Chen J, Sapieha P, Smith LE, Ma JX. Neurovascular cross talk in diabetic retinopathy: Pathophysiological roles and therapeutic implications. Am J Physiol Heart Circ Physiol. 2016 09 01; 311(3):H738-49. PMID: 27473938.
    Citations: 6     Fields:    Translation:HumansCells
  40. Gong Y, Fu Z, Edin ML, Liu CH, Wang Z, Shao Z, Fredrick TW, Saba NJ, Morss PC, Burnim SB, Meng SS, Lih FB, Lee KS, Moran EP, SanGiovanni JP, Hellström A, Hammock BD, Zeldin DC, Smith LE. Cytochrome P450 Oxidase 2C Inhibition Adds to ?-3 Long-Chain Polyunsaturated Fatty Acids Protection Against Retinal and Choroidal Neovascularization. Arterioscler Thromb Vasc Biol. 2016 09; 36(9):1919-27. PMID: 27417579.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  41. Joyal JS, Sun Y, Gantner ML, Shao Z, Evans LP, Saba N, Fredrick T, Burnim S, Kim JS, Patel G, Juan AM, Hurst CG, Hatton CJ, Cui Z, Pierce KA, Bherer P, Aguilar E, Powner MB, Vevis K, Boisvert M, Fu Z, Levy E, Fruttiger M, Packard A, Rezende FA, Maranda B, Sapieha P, Chen J, Friedlander M, Clish CB, Smith LE. Corrigendum: Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1. Nat Med. 2016 06 07; 22(6):692. PMID: 27270778.
    Citations: 1     Fields:    
  42. Fu Z, Gong Y, Löfqvist C, Hellström A, Smith LE. Review: adiponectin in retinopathy. Biochim Biophys Acta. 2016 08; 1862(8):1392-400. PMID: 27155572.
    Citations: 6     Fields:    
  43. Joyal JS, Sun Y, Gantner ML, Shao Z, Evans LP, Saba N, Fredrick T, Burnim S, Kim JS, Patel G, Juan AM, Hurst CG, Hatton CJ, Cui Z, Pierce KA, Bherer P, Aguilar E, Powner MB, Vevis K, Boisvert M, Fu Z, Levy E, Fruttiger M, Packard A, Rezende FA, Maranda B, Sapieha P, Chen J, Friedlander M, Clish CB, Smith LE. Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1. Nat Med. 2016 Apr; 22(4):439-45. PMID: 26974308.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  44. Hellström A, Ley D, Hansen-Pupp I, Hallberg B, Löfqvist C, van Marter L, van Weissenbruch M, Ramenghi LA, Beardsall K, Dunger D, Hård AL, Smith LE. Insulin-like growth factor 1 has multisystem effects on foetal and preterm infant development. Acta Paediatr. 2016 Jun; 105(6):576-86. PMID: 26833743.
    Citations: 13     Fields:    Translation:HumansAnimals
  45. Wang Y, Tadjuidje E, Pandey RN, Stefater JA, Smith LE, Lang RA, Hegde RS. The Eyes Absent Proteins in Developmental and Pathological Angiogenesis. Am J Pathol. 2016 Mar; 186(3):568-78. PMID: 26765957.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  46. Sun Y, Ju M, Lin Z, Fredrick TW, Evans LP, Tian KT, Saba NJ, Morss PC, Pu WT, Chen J, Stahl A, Joyal JS, Smith LE. SOCS3 in retinal neurons and glial cells suppresses VEGF signaling to prevent pathological neovascular growth. Sci Signal. 2015 Sep 22; 8(395):ra94. PMID: 26396267.
    Citations: 9     Fields:    Translation:AnimalsCells
  47. Hellgren G, Löfqvist C, Hård AL, Hansen-Pupp I, Gram M, Ley D, Smith LE, Hellström A. Serum concentrations of vascular endothelial growth factor in relation to retinopathy of prematurity. Pediatr Res. 2016 Jan; 79(1-1):70-5. PMID: 26372519.
    Citations: 3     Fields:    Translation:Humans
  48. Gong Y, Li J, Sun Y, Fu Z, Liu CH, Evans L, Tian K, Saba N, Fredrick T, Morss P, Chen J, Smith LE. Optimization of an Image-Guided Laser-Induced Choroidal Neovascularization Model in Mice. PLoS One. 2015; 10(7):e0132643. PMID: 26161975.
    Citations: 13     Fields:    Translation:AnimalsCells
  49. Srinivasan S, Chitalia V, Meyer RD, Hartsough E, Mehta M, Harrold I, Anderson N, Feng H, Smith LE, Jiang Y, Costello CE, Rahimi N. Hypoxia-induced expression of phosducin-like 3 regulates expression of VEGFR-2 and promotes angiogenesis. Angiogenesis. 2015 Oct; 18(4):449-62. PMID: 26059764.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  50. SanGiovanni JP, Chen J, Gupta AS, Smith LE, Sapieha P, Lee PH. Netrin-1 - DCC Signaling Systems and Age-Related Macular Degeneration. PLoS One. 2015; 10(5):e0125548. PMID: 25950802.
    Citations: 1     Fields:    Translation:HumansCells
  51. Hellgren G, Engström E, Smith LE, Löfqvist C, Hellström A. Effect of Preterm Birth on Postnatal Apolipoprotein and Adipocytokine Profiles. Neonatology. 2015; 108(1):16-22. PMID: 25925609.
    Citations: 1     Fields:    Translation:Humans
  52. Fu Z, Lofqvist CA, Shao Z, Sun Y, Joyal JS, Hurst CG, Cui RZ, Evans LP, Tian K, SanGiovanni JP, Chen J, Ley D, Hansen Pupp I, Hellstrom A, Smith LE. Dietary ?-3 polyunsaturated fatty acids decrease retinal neovascularization by adipose-endoplasmic reticulum stress reduction to increase adiponectin. Am J Clin Nutr. 2015 Apr; 101(4):879-88. PMID: 25833984.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  53. Lundgren P, Kistner A, Andersson EM, Hansen Pupp I, Holmström G, Ley D, Niklasson A, Smith LE, Wu C, Hellström A, Löfqvist C. Low birth weight is a risk factor for severe retinopathy of prematurity depending on gestational age. PLoS One. 2014; 9(10):e109460. PMID: 25330287.
    Citations: 4     Fields:    Translation:Humans
  54. Stahl A, Hellstrom A, Smith LE. Insulin-like growth factor-1 and anti-vascular endothelial growth factor in retinopathy of prematurity: has the time come? Neonatology. 2014; 106(3):254-60. PMID: 25300950.
    Citations: 7     Fields:    Translation:Humans
  55. Rezende FA, Lapalme E, Qian CX, Smith LE, SanGiovanni JP, Sapieha P. Omega-3 supplementation combined with anti-vascular endothelial growth factor lowers vitreal levels of vascular endothelial growth factor in wet age-related macular degeneration. Am J Ophthalmol. 2014 Nov; 158(5):1071-78. PMID: 25089351.
    Citations: 4     Fields:    Translation:Humans
  56. Lundgren P, Wilde Å, Löfqvist C, Smith LE, Hård AL, Hellström A. Weight at first detection of retinopathy of prematurity predicts disease severity. Br J Ophthalmol. 2014 Nov; 98(11):1565-9. PMID: 24963022.
    Citations: 2     Fields:    Translation:Humans
  57. Shao Z, Fu Z, Stahl A, Joyal JS, Hatton C, Juan A, Hurst C, Evans L, Cui Z, Pei D, Gong Y, Xu D, Tian K, Bogardus H, Edin ML, Lih F, Sapieha P, Chen J, Panigrahy D, Hellstrom A, Zeldin DC, Smith LE. Cytochrome P450 2C8 ?3-long-chain polyunsaturated fatty acid metabolites increase mouse retinal pathologic neovascularization--brief report. Arterioscler Thromb Vasc Biol. 2014 Mar; 34(3):581-6. PMID: 24458713.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  58. Michan S, Juan AM, Hurst CG, Cui Z, Evans LP, Hatton CJ, Pei DT, Ju M, Sinclair DA, Smith LE, Chen J. Sirtuin1 over-expression does not impact retinal vascular and neuronal degeneration in a mouse model of oxygen-induced retinopathy. PLoS One. 2014; 9(1):e85031. PMID: 24416337.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  59. Lundgren P, Stoltz Sjöström E, Domellöf M, Källen K, Holmström G, Hård AL, Smith LE, Löfqvist C, Hellström A. WINROP identifies severe retinopathy of prematurity at an early stage in a nation-based cohort of extremely preterm infants. PLoS One. 2013; 8(9):e73256. PMID: 24069180.
    Citations: 8     Fields:    Translation:HumansAnimals
  60. Chen J, Michan S, Juan AM, Hurst CG, Hatton CJ, Pei DT, Joyal JS, Evans LP, Cui Z, Stahl A, Sapieha P, Sinclair DA, Smith LE. Neuronal sirtuin1 mediates retinal vascular regeneration in oxygen-induced ischemic retinopathy. Angiogenesis. 2013 Oct; 16(4):985-92. PMID: 23912262.
    Citations: 11     Fields:    Translation:AnimalsCells
  61. Shao Z, Friedlander M, Hurst CG, Cui Z, Pei DT, Evans LP, Juan AM, Tahiri H, Tahir H, Duhamel F, Chen J, Sapieha P, Chemtob S, Joyal JS, Smith LE. Choroid sprouting assay: an ex vivo model of microvascular angiogenesis. PLoS One. 2013; 8(7):e69552. PMID: 23922736.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  62. Hellström A, Smith LE, Dammann O. Retinopathy of prematurity. Lancet. 2013 Oct 26; 382(9902):1445-57. PMID: 23782686.
    Citations: 82     Fields:    Translation:Humans
  63. Smith LE, Hard AL, Hellström A. The biology of retinopathy of prematurity: how knowledge of pathogenesis guides treatment. Clin Perinatol. 2013 Jun; 40(2):201-14. PMID: 23719305.
    Citations: 16     Fields:    Translation:Humans
  64. Buehler A, Sitaras N, Favret S, Bucher F, Berger S, Pielen A, Joyal JS, Juan AM, Martin G, Schlunck G, Agostini HT, Klagsbrun M, Smith LE, Sapieha P, Stahl A. Semaphorin 3F forms an anti-angiogenic barrier in outer retina. FEBS Lett. 2013 Jun 05; 587(11):1650-5. PMID: 23603393.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  65. Chen J, Smith LE. Altered cholesterol homeostasis in aged macrophages linked to neovascular macular degeneration. Cell Metab. 2013 Apr 02; 17(4):471-2. PMID: 23562072.
    Citations: 1     Fields:    
  66. Hård AL, Smith LE, Hellström A. Nutrition, insulin-like growth factor-1 and retinopathy of prematurity. Semin Fetal Neonatal Med. 2013 Jun; 18(3):136-142. PMID: 23428885.
    Citations: 6     Fields:    
  67. SanGiovanni JP, Chen J, Sapieha P, Aderman CM, Stahl A, Clemons TE, Chew EY, Smith LE. DNA sequence variants in PPARGC1A, a gene encoding a coactivator of the ?-3 LCPUFA sensing PPAR-RXR transcription complex, are associated with NV AMD and AMD-associated loci in genes of complement and VEGF signaling pathways. PLoS One. 2013; 8(1):e53155. PMID: 23335958.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  68. Chen J, Hellstrom A, Smith LE. Author response: Different efficacy of propranolol in mice with oxygen-induced retinopathy: could differential effects of propranolol be related to differences in mouse strains? Invest Ophthalmol Vis Sci. 2012 Nov 19; 53(12):7728-9. PMID: 23166302.
    Citations:    Fields:    Translation:HumansAnimals
  69. Ley D, Hansen-Pupp I, Niklasson A, Domellöf M, Friberg LE, Borg J, Löfqvist C, Hellgren G, Smith LE, Hård AL, Hellström A. Longitudinal infusion of a complex of insulin-like growth factor-I and IGF-binding protein-3 in five preterm infants: pharmacokinetics and short-term safety. Pediatr Res. 2013 Jan; 73(1):68-74. PMID: 23095978.
    Citations: 10     Fields:    Translation:HumansCTClinical Trials
  70. Wu C, Löfqvist C, Smith LE, VanderVeen DK, Hellström A. Importance of early postnatal weight gain for normal retinal angiogenesis in very preterm infants: a multicenter study analyzing weight velocity deviations for the prediction of retinopathy of prematurity. Arch Ophthalmol. 2012 Aug; 130(8):992-9. PMID: 22491391.
    Citations: 18     Fields:    Translation:Humans
  71. Mammoto T, Chen J, Jiang E, Jiang A, Smith LE, Ingber DE, Mammoto A. LRP5 regulates development of lung microvessels and alveoli through the angiopoietin-Tie2 pathway. PLoS One. 2012; 7(7):e41596. PMID: 22848540.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  72. Stahl A, Joyal JS, Chen J, Sapieha P, Juan AM, Hatton CJ, Pei DT, Hurst CG, Seaward MR, Krah NM, Dennison RJ, Greene ER, Boscolo E, Panigrahy D, Smith LE. SOCS3 is an endogenous inhibitor of pathologic angiogenesis. Blood. 2012 Oct 04; 120(14):2925-9. PMID: 22791286.
    Citations: 19     Fields:    Translation:AnimalsCells
  73. Chen J, Joyal JS, Hatton CJ, Juan AM, Pei DT, Hurst CG, Xu D, Stahl A, Hellstrom A, Smith LE. Propranolol inhibition of ß-adrenergic receptor does not suppress pathologic neovascularization in oxygen-induced retinopathy. Invest Ophthalmol Vis Sci. 2012 May 17; 53(6):2968-77. PMID: 22491401.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  74. Chen J, Smith LE. Protective inflammasome activation in AMD. Nat Med. 2012 May 04; 18(5):658-60. PMID: 22561819.
    Citations: 2     Fields:    Translation:Animals
  75. Chen J, Stahl A, Krah NM, Seaward MR, Joyal JS, Juan AM, Hatton CJ, Aderman CM, Dennison RJ, Willett KL, Sapieha P, Smith LE. Retinal expression of Wnt-pathway mediated genes in low-density lipoprotein receptor-related protein 5 (Lrp5) knockout mice. PLoS One. 2012; 7(1):e30203. PMID: 22272305.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  76. Chen J, Stahl A, Krah NM, Seaward MR, Dennison RJ, Sapieha P, Hua J, Hatton CJ, Juan AM, Aderman CM, Willett KL, Guerin KI, Mammoto A, Campbell M, Smith LE. Wnt signaling mediates pathological vascular growth in proliferative retinopathy. Circulation. 2011 Oct 25; 124(17):1871-81. PMID: 21969016.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  77. Tang M, Chen B, Lin T, Li Z, Pardo C, Pampo C, Chen J, Lien CL, Wu L, Ai L, Wang H, Yao K, Oh SP, Seto E, Smith LE, Siemann DW, Kladde MP, Cepko CL, Lu J. Restraint of angiogenesis by zinc finger transcription factor CTCF-dependent chromatin insulation. Proc Natl Acad Sci U S A. 2011 Sep 13; 108(37):15231-6. PMID: 21896759.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  78. Zaniolo K, Sapieha P, Shao Z, Stahl A, Zhu T, Tremblay S, Picard E, Madaan A, Blais M, Lachapelle P, Mancini J, Hardy P, Smith LE, Ong H, Chemtob S. Ghrelin modulates physiologic and pathologic retinal angiogenesis through GHSR-1a. Invest Ophthalmol Vis Sci. 2011 Jul 23; 52(8):5376-86. PMID: 21642627.
    Citations: 5     Fields:    Translation:HumansAnimals
  79. Wikstrand MH, Hård AL, Niklasson A, Smith L, Löfqvist C, Hellström A. Maternal and neonatal factors associated with poor early weight gain and later retinopathy of prematurity. Acta Paediatr. 2011 Dec; 100(12):1528-33. PMID: 21726282.
    Citations: 9     Fields:    Translation:HumansPHPublic Health
  80. Hua J, Guerin KI, Chen J, Michán S, Stahl A, Krah NM, Seaward MR, Dennison RJ, Juan AM, Hatton CJ, Sapieha P, Sinclair DA, Smith LE. Resveratrol inhibits pathologic retinal neovascularization in Vldlr(-/-) mice. Invest Ophthalmol Vis Sci. 2011 Apr; 52(5):2809-16. PMID: 21282584.
    Citations: 28     Fields:    Translation:Animals
  81. Chen J, Stahl A, Hellstrom A, Smith LE. Current update on retinopathy of prematurity: screening and treatment. Curr Opin Pediatr. 2011 Apr; 23(2):173-8. PMID: 21150442.
    Citations: 35     Fields:    Translation:HumansPHPublic Health
  82. Stahl A, Krohne TU, Sapieha P, Chen J, Hellstrom A, Chew E, Holz FG, Smith LE. Lipid metabolites in the pathogenesis and treatment of neovascular eye disease. Br J Ophthalmol. 2011 Nov; 95(11):1496-501. PMID: 21421650.
    Citations: 10     Fields:    Translation:HumansCells
  83. Joyal JS, Sitaras N, Binet F, Rivera JC, Stahl A, Zaniolo K, Shao Z, Polosa A, Zhu T, Hamel D, Djavari M, Kunik D, Honoré JC, Picard E, Zabeida A, Varma DR, Hickson G, Mancini J, Klagsbrun M, Costantino S, Beauséjour C, Lachapelle P, Smith LE, Chemtob S, Sapieha P. Ischemic neurons prevent vascular regeneration of neural tissue by secreting semaphorin 3A. Blood. 2011 Jun 02; 117(22):6024-35. PMID: 21355092.
    Citations: 51     Fields:    Translation:AnimalsCells
  84. Sapieha P, Stahl A, Chen J, Seaward MR, Willett KL, Krah NM, Dennison RJ, Connor KM, Aderman CM, Liclican E, Carughi A, Perelman D, Kanaoka Y, Sangiovanni JP, Gronert K, Smith LE. 5-Lipoxygenase metabolite 4-HDHA is a mediator of the antiangiogenic effect of ?-3 polyunsaturated fatty acids. Sci Transl Med. 2011 Feb 09; 3(69):69ra12. PMID: 21307302.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  85. Parmalee NL, Schubert C, Merriam JE, Allikmets K, Bird AC, Gillies MC, Peto T, Figueroa M, Friedlander M, Fruttiger M, Greenwood J, Moss SE, Smith LE, Toomes C, Inglehearn CF, Allikmets R. Analysis of candidate genes for macular telangiectasia type 2. Mol Vis. 2010 Dec 14; 16:2718-26. PMID: 21179236.
    Citations: 6     Fields:    Translation:HumansAnimals
  86. Stahl A, Chen J, Sapieha P, Seaward MR, Krah NM, Dennison RJ, Favazza T, Bucher F, Löfqvist C, Ong H, Hellström A, Chemtob S, Akula JD, Smith LE. Postnatal weight gain modifies severity and functional outcome of oxygen-induced proliferative retinopathy. Am J Pathol. 2010 Dec; 177(6):2715-23. PMID: 21056995.
    Citations: 29     Fields:    Translation:HumansAnimals
  87. Hård AL, Löfqvist C, Fortes Filho JB, Procianoy RS, Smith L, Hellström A. Predicting proliferative retinopathy in a Brazilian population of preterm infants with the screening algorithm WINROP. Arch Ophthalmol. 2010 Nov; 128(11):1432-6. PMID: 21060045.
    Citations: 16     Fields:    Translation:HumansPHPublic Health
  88. Stahl A, Buchwald A, Martin G, Junker B, Chen J, Hansen LL, Agostini HT, Smith LE, Feltgen N. Vitreal levels of erythropoietin are increased in patients with retinal vein occlusion and correlate with vitreal VEGF and the extent of macular edema. Retina. 2010 Oct; 30(9):1524-9. PMID: 20664492.
    Citations: 11     Fields:    Translation:HumansCells
  89. Hoang MV, Smith LE, Senger DR. Calpain inhibitors reduce retinal hypoxia in ischemic retinopathy by improving neovascular architecture and functional perfusion. Biochim Biophys Acta. 2011 Apr; 1812(4):549-57. PMID: 20804843.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  90. Hoang MV, Smith LE, Senger DR. Moderate GSK-3ß inhibition improves neovascular architecture, reduces vascular leakage, and reduces retinal hypoxia in a model of ischemic retinopathy. Angiogenesis. 2010 Sep; 13(3):269-77. PMID: 20809259.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  91. Stahl A, Smith LE. An eye for discovery. J Clin Invest. 2010 Sep; 120(9):3008-11. PMID: 20811156.
    Citations: 3     Fields:    Translation:Humans
  92. Michán S, Li Y, Chou MM, Parrella E, Ge H, Long JM, Allard JS, Lewis K, Miller M, Xu W, Mervis RF, Chen J, Guerin KI, Smith LE, McBurney MW, Sinclair DA, Baudry M, de Cabo R, Longo VD. SIRT1 is essential for normal cognitive function and synaptic plasticity. J Neurosci. 2010 Jul 21; 30(29):9695-707. PMID: 20660252.
    Citations: 114     Fields:    Translation:AnimalsCells
  93. Stahl A, Sapieha P, Connor KM, Sangiovanni JP, Chen J, Aderman CM, Willett KL, Krah NM, Dennison RJ, Seaward MR, Guerin KI, Hua J, Smith LE. Short communication: PPAR gamma mediates a direct antiangiogenic effect of omega 3-PUFAs in proliferative retinopathy. Circ Res. 2010 Aug 20; 107(4):495-500. PMID: 20634487.
    Citations: 33     Fields:    Translation:Animals
  94. Stahl A, Connor KM, Sapieha P, Chen J, Dennison RJ, Krah NM, Seaward MR, Willett KL, Aderman CM, Guerin KI, Hua J, Löfqvist C, Hellström A, Smith LE. The mouse retina as an angiogenesis model. Invest Ophthalmol Vis Sci. 2010 Jun; 51(6):2813-26. PMID: 20484600.
    Citations: 154     Fields:    Translation:Animals
  95. Chen ML, Guo L, Smith LE, Dammann CE, Dammann O. High or low oxygen saturation and severe retinopathy of prematurity: a meta-analysis. Pediatrics. 2010 Jun; 125(6):e1483-92. PMID: 20498174.
    Citations: 32     Fields:    Translation:Humans
  96. Wu C, Vanderveen DK, Hellström A, Löfqvist C, Smith LE. Longitudinal postnatal weight measurements for the prediction of retinopathy of prematurity. Arch Ophthalmol. 2010 Apr; 128(4):443-7. PMID: 20385939.
    Citations: 25     Fields:    Translation:HumansPHPublic Health
  97. Connor KM, Krah NM, Dennison RJ, Aderman CM, Chen J, Guerin KI, Sapieha P, Stahl A, Willett KL, Smith LE. Quantification of oxygen-induced retinopathy in the mouse: a model of vessel loss, vessel regrowth and pathological angiogenesis. Nat Protoc. 2009; 4(11):1565-73. PMID: 19816419.
    Citations: 178     Fields:    Translation:Animals
  98. Löfqvist C, Niklasson A, Engström E, Friberg LE, Camacho-Hübner C, Ley D, Borg J, Smith LE, Hellström A. A pharmacokinetic and dosing study of intravenous insulin-like growth factor-I and IGF-binding protein-3 complex to preterm infants. Pediatr Res. 2009 May; 65(5):574-9. PMID: 19190540.
    Citations: 16     Fields:    Translation:HumansCTClinical Trials
  99. Löfqvist C, Hansen-Pupp I, Andersson E, Holm K, Smith LE, Ley D, Hellström A. Validation of a new retinopathy of prematurity screening method monitoring longitudinal postnatal weight and insulinlike growth factor I. Arch Ophthalmol. 2009 May; 127(5):622-7. PMID: 19433710.
    Citations: 36     Fields:    Translation:Humans
  100. Hellström A, Hård AL, Engström E, Niklasson A, Andersson E, Smith L, Löfqvist C. Early weight gain predicts retinopathy in preterm infants: new, simple, efficient approach to screening. Pediatrics. 2009 Apr; 123(4):e638-45. PMID: 19289449.
    Citations: 44     Fields:    Translation:HumansPHPublic Health
  101. Heidary G, Vanderveen D, Smith LE. Retinopathy of prematurity: current concepts in molecular pathogenesis. Semin Ophthalmol. 2009 Mar-Apr; 24(2):77-81. PMID: 19373690.
    Citations: 23     Fields:    Translation:HumansAnimals
  102. Mantagos IS, Vanderveen DK, Smith LE. Emerging treatments for retinopathy of prematurity. Semin Ophthalmol. 2009 Mar-Apr; 24(2):82-6. PMID: 19373691.
    Citations: 11     Fields:    Translation:HumansAnimals
  103. Mammoto A, Connor KM, Mammoto T, Yung CW, Huh D, Aderman CM, Mostoslavsky G, Smith LE, Ingber DE. A mechanosensitive transcriptional mechanism that controls angiogenesis. Nature. 2009 Feb 26; 457(7233):1103-8. PMID: 19242469.
    Citations: 183     Fields:    Translation:HumansAnimalsCells
  104. Lofqvist C, Willett KL, Aspegren O, Smith AC, Aderman CM, Connor KM, Chen J, Hellstrom A, Smith LE. Quantification and localization of the IGF/insulin system expression in retinal blood vessels and neurons during oxygen-induced retinopathy in mice. Invest Ophthalmol Vis Sci. 2009 Apr; 50(4):1831-7. PMID: 18997086.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  105. Chen J, Connor KM, Aderman CM, Willett KL, Aspegren OP, Smith LE. Suppression of retinal neovascularization by erythropoietin siRNA in a mouse model of proliferative retinopathy. Invest Ophthalmol Vis Sci. 2009 Mar; 50(3):1329-35. PMID: 18952918.
    Citations: 61     Fields:    Translation:HumansAnimals
  106. English SB, Shih SC, Ramoni MF, Smith LE, Butte AJ. Use of Bayesian networks to probabilistically model and improve the likelihood of validation of microarray findings by RT-PCR. J Biomed Inform. 2009 Apr; 42(2):287-95. PMID: 18790084.
    Citations: 1     Fields:    Translation:Animals
  107. Smith LE. Through the eyes of a child: understanding retinopathy through ROP the Friedenwald lecture. Invest Ophthalmol Vis Sci. 2008 Dec; 49(12):5177-82. PMID: 18708611.
    Citations: 46     Fields:    Translation:HumansAnimals
  108. Chen J, Smith LE. A double-edged sword: erythropoietin eyed in retinopathy of prematurity. J AAPOS. 2008 Jun; 12(3):221-2. PMID: 18396079.
    Citations: 4     Fields:    Translation:HumansAnimals
  109. Chen J, Connor KM, Aderman CM, Smith LE. Erythropoietin deficiency decreases vascular stability in mice. J Clin Invest. 2008 Feb; 118(2):526-33. PMID: 18219389.
    Citations: 104     Fields:    Translation:AnimalsCells
  110. Chen J, Connor KM, Smith LE. Overstaying their welcome: defective CX3CR1 microglia eyed in macular degeneration. J Clin Invest. 2007 Oct; 117(10):2758-62. PMID: 17909623.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  111. Connor KM, SanGiovanni JP, Lofqvist C, Aderman CM, Chen J, Higuchi A, Hong S, Pravda EA, Majchrzak S, Carper D, Hellstrom A, Kang JX, Chew EY, Salem N, Serhan CN, Smith LEH. Increased dietary intake of omega-3-polyunsaturated fatty acids reduces pathological retinal angiogenesis. Nat Med. 2007 Jul; 13(7):868-873. PMID: 17589522.
    Citations: 207     Fields:    Translation:Animals
  112. Lofqvist C, Chen J, Connor KM, Smith AC, Aderman CM, Liu N, Pintar JE, Ludwig T, Hellstrom A, Smith LE. IGFBP3 suppresses retinopathy through suppression of oxygen-induced vessel loss and promotion of vascular regrowth. Proc Natl Acad Sci U S A. 2007 Jun 19; 104(25):10589-94. PMID: 17567756.
    Citations: 67     Fields:    Translation:HumansAnimalsCTClinical Trials
  113. Chen J, Smith LE. Retinopathy of prematurity. Angiogenesis. 2007; 10(2):133-40. PMID: 17332988.
    Citations: 150     Fields:    Translation:HumansAnimals
  114. Löfqvist C, Andersson E, Sigurdsson J, Engström E, Hård AL, Niklasson A, Smith LE, Hellström A. Longitudinal postnatal weight and insulin-like growth factor I measurements in the prediction of retinopathy of prematurity. Arch Ophthalmol. 2006 Dec; 124(12):1711-8. PMID: 17159030.
    Citations: 54     Fields:    Translation:Humans
  115. Löfqvist C, Engström E, Sigurdsson J, Hård AL, Niklasson A, Ewald U, Holmström G, Smith LE, Hellström A. Postnatal head growth deficit among premature infants parallels retinopathy of prematurity and insulin-like growth factor-1 deficit. Pediatrics. 2006 Jun; 117(6):1930-8. PMID: 16740833.
    Citations: 23     Fields:    Translation:Humans
  116. Lutty GA, Chan-Ling T, Phelps DL, Adamis AP, Berns KI, Chan CK, Cole CH, D'Amore PA, Das A, Deng WT, Dobson V, Flynn JT, Friedlander M, Fulton A, Good WV, Grant MB, Hansen R, Hauswirth WW, Hardy RJ, Hinton DR, Hughes S, McLeod DS, Palmer EA, Patz A, Penn JS, Raisler BJ, Repka MX, Saint-Geniez M, Shaw LC, Shima DT, Smith BT, Smith LE, Tahija SG, Tasman W, Trese MT. Proceedings of the Third International Symposium on Retinopathy of Prematurity: an update on ROP from the lab to the nursery (November 2003, Anaheim, California). Mol Vis. 2006 May 23; 12:532-80. PMID: 16735995.
    Citations: 16     Fields:    Translation:Humans
  117. Smith LE, Connor KM. A radically twisted lipid regulates vascular death. Nat Med. 2005 Dec; 11(12):1275-6. PMID: 16333261.
    Citations: 1     Fields:    Translation:Humans
  118. Notari L, Miller A, Martínez A, Amaral J, Ju M, Robinson G, Smith LE, Becerra SP. Pigment epithelium-derived factor is a substrate for matrix metalloproteinase type 2 and type 9: implications for downregulation in hypoxia. Invest Ophthalmol Vis Sci. 2005 Aug; 46(8):2736-47. PMID: 16043845.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  119. Shih SC, Smith LE. Quantitative multi-gene transcriptional profiling using real-time PCR with a master template. Exp Mol Pathol. 2005 Aug; 79(1):14-22. PMID: 15894312.
    Citations: 29     Fields:    Translation:HumansCells
  120. Greene AK, Burrows PE, Smith L, Mulliken JB. Periorbital lymphatic malformation: clinical course and management in 42 patients. Plast Reconstr Surg. 2005 Jan; 115(1):22-30. PMID: 15622227.
    Citations: 10     Fields:    Translation:Humans
  121. Smith LE. IGF-1 and retinopathy of prematurity in the preterm infant. Biol Neonate. 2005; 88(3):237-44. PMID: 16210846.
    Citations: 17     Fields:    Translation:Humans
  122. Adam RM, Eaton SH, Estrada C, Nimgaonkar A, Shih SC, Smith LE, Kohane IS, Bägli D, Freeman MR. Mechanical stretch is a highly selective regulator of gene expression in human bladder smooth muscle cells. Physiol Genomics. 2004 Dec 15; 20(1):36-44. PMID: 15467014.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  123. Smith LE. Bone marrow-derived stem cells preserve cone vision in retinitis pigmentosa. J Clin Invest. 2004 Sep; 114(6):755-7. PMID: 15372096.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  124. Smith LE. Can we restore aspects of the in utero environment in premature infants to prevent disease? Pediatrics. 2004 Aug; 114(2):491. PMID: 15286236.
    Citations:    Fields:    Translation:Humans
  125. Smith LE. Pathogenesis of retinopathy of prematurity. Growth Horm IGF Res. 2004 Jun; 14 Suppl A:S140-4. PMID: 15135797.
    Citations: 46     Fields:    Translation:HumansAnimals
  126. Shih SC, Ju M, Liu N, Mo JR, Ney JJ, Smith LE. Transforming growth factor beta1 induction of vascular endothelial growth factor receptor 1: mechanism of pericyte-induced vascular survival in vivo. Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):15859-64. PMID: 14657382.
    Citations: 24     Fields:    Translation:Animals
  127. Smith LE. Pathogenesis of retinopathy of prematurity. Semin Neonatol. 2003 Dec; 8(6):469-73. PMID: 15001119.
    Citations: 33     Fields:    Translation:HumansPHPublic Health
  128. Dallabrida SM, Zurakowski D, Shih SC, Smith LE, Folkman J, Moulton KS, Rupnick MA. Adipose tissue growth and regression are regulated by angiopoietin-1. Biochem Biophys Res Commun. 2003 Nov 21; 311(3):563-71. PMID: 14623307.
    Citations: 17     Fields:    Translation:AnimalsCells
  129. Hellström A, Engström E, Hård AL, Albertsson-Wikland K, Carlsson B, Niklasson A, Löfqvist C, Svensson E, Holm S, Ewald U, Holmström G, Smith LE. Postnatal serum insulin-like growth factor I deficiency is associated with retinopathy of prematurity and other complications of premature birth. Pediatrics. 2003 Nov; 112(5):1016-20. PMID: 14595040.
    Citations: 80     Fields:    Translation:Humans
  130. Shih SC, Ju M, Liu N, Smith LE. Selective stimulation of VEGFR-1 prevents oxygen-induced retinal vascular degeneration in retinopathy of prematurity. J Clin Invest. 2003 Jul; 112(1):50-7. PMID: 12840058.
    Citations: 42     Fields:    Translation:HumansAnimals
  131. Calvo A, Yokoyama Y, Smith LE, Ali I, Shih SC, Feldman AL, Libutti SK, Sundaram R, Green JE. Inhibition of the mammary carcinoma angiogenic switch in C3(1)/SV40 transgenic mice by a mutated form of human endostatin. Int J Cancer. 2002 Sep 20; 101(3):224-34. PMID: 12209972.
    Citations: 13     Fields:    Translation:HumansAnimals
  132. Smith LE. Stem cells go for the eyes. Nat Med. 2002 Sep; 8(9):932-4. PMID: 12205451.
    Citations:    Fields:    Translation:HumansAnimalsCells
  133. Hellström A, Carlsson B, Niklasson A, Segnestam K, Boguszewski M, de Lacerda L, Savage M, Svensson E, Smith L, Weinberger D, Albertsson Wikland K, Laron Z. IGF-I is critical for normal vascularization of the human retina. J Clin Endocrinol Metab. 2002 Jul; 87(7):3413-6. PMID: 12107259.
    Citations: 41     Fields:    Translation:Humans
  134. Shih SC, Robinson GS, Perruzzi CA, Calvo A, Desai K, Green JE, Ali IU, Smith LE, Senger DR. Molecular profiling of angiogenesis markers. Am J Pathol. 2002 Jul; 161(1):35-41. PMID: 12107087.
    Citations: 44     Fields:    Translation:Animals
  135. Smith LE, Hellstrom A. RP-forme fruste. J Perinatol. 2002 Apr-May; 22(3):257; author reply 257-8. PMID: 11985286.
    Citations:    Fields:    Translation:Humans
  136. Smith LE. Pathogenesis of retinopathy of prematurity. Acta Paediatr Suppl. 2002; 91(437):26-8. PMID: 12200894.
    Citations: 28     Fields:    Translation:HumansAnimals
  137. Bernstein SL, Russell P, Wong P, Fishelevich R, Smith LE. Heat shock protein 90 in retinal ganglion cells: association with axonally transported proteins. Vis Neurosci. 2001 May-Jun; 18(3):429-36. PMID: 11497419.
    Citations: 5     Fields:    Translation:AnimalsCells
  138. Hellstrom A, Perruzzi C, Ju M, Engstrom E, Hard AL, Liu JL, Albertsson-Wikland K, Carlsson B, Niklasson A, Sjodell L, LeRoith D, Senger DR, Smith LE. Low IGF-I suppresses VEGF-survival signaling in retinal endothelial cells: direct correlation with clinical retinopathy of prematurity. Proc Natl Acad Sci U S A. 2001 May 08; 98(10):5804-8. PMID: 11331770.
    Citations: 99     Fields:    Translation:HumansCells
  139. Robinson GS, Ju M, Shih SC, Xu X, McMahon G, Caldwell RB, Smith LE. Nonvascular role for VEGF: VEGFR-1, 2 activity is critical for neural retinal development. FASEB J. 2001 May; 15(7):1215-7. PMID: 11344092.
    Citations: 42     Fields:    Translation:HumansAnimals
  140. Ali IU, Senger DR, Smith LE. Angiogenesis as a potential biomarker in prostate cancer chemoprevention trials. Urology. 2001 Apr; 57(4 Suppl 1):143-7. PMID: 11295614.
    Citations: 2     Fields:    Translation:HumansAnimals
  141. Smith LE, Shen W, Perruzzi C, Soker S, Kinose F, Xu X, Robinson G, Driver S, Bischoff J, Zhang B, Schaeffer JM, Senger DR. Regulation of vascular endothelial growth factor-dependent retinal neovascularization by insulin-like growth factor-1 receptor. Nat Med. 1999 Dec; 5(12):1390-5. PMID: 10581081.
    Citations: 113     Fields:    Translation:HumansAnimalsCells
  142. Driver SE, Robinson GS, Flanagan J, Shen W, Smith LE, Thomas DW, Roberts PC. Oligonucleotide-based inhibition of embryonic gene expression. Nat Biotechnol. 1999 Dec; 17(12):1184-7. PMID: 10585715.
    Citations: 5     Fields:    Translation:AnimalsCells
  143. Stephan DA, Gillanders E, Vanderveen D, Freas-Lutz D, Wistow G, Baxevanis AD, Robbins CM, VanAuken A, Quesenberry MI, Bailey-Wilson J, Jou SH, Trent JM, Smith L, Brownstein MJ. Progressive juvenile onset punctate cataracts caused by mutation of the gamma D crystalline gene. Proc Natl Acad Sci USA. 1999; 96(3):1008-1012.
  144. Aiello LP, Bursell SE, Clermont A, Duh E, Ishii H, Takagi C, Mori F, Ciulla TA, Ways K, Jirousek M, Smith LE, King GL. Vascular endothelial growth factor-induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective beta-isoform-selective inhibitor. Diabetes. 1997 Sep; 46(9):1473-80. PMID: 9287049.
    Citations: 148     Fields:    Translation:AnimalsCells
  145. Smith LE, Kopchick JJ, Chen W, Knapp J, Kinose F, Daley D, Foley E, Smith RG, Schaeffer JM. Essential role of growth hormone in ischemia-induced retinal neovascularization. Science. 1997 Jun 13; 276(5319):1706-9. PMID: 9180082.
    Citations: 63     Fields:    Translation:Animals
  146. Young TL, Anthony DC, Pierce E, Foley E, Smith LE. Histopathology and vascular endothelial growth factor in untreated and diode laser-treated retinopathy of prematurity. J AAPOS. 1997 Jun; 1(2):105-10. PMID: 10875087.
    Citations: 22     Fields:    Translation:HumansCells
  147. Pierce EA, Foley ED, Smith LE. Regulation of vascular endothelial growth factor by oxygen in a model of retinopathy of prematurity. Arch Ophthalmol. 1996 Oct; 114(10):1219-28. PMID: 8859081.
    Citations: 103     Fields:    Translation:HumansAnimalsCells
  148. Robinson GS, Pierce EA, Rook SL, Foley E, Webb R, Smith LE. Oligodeoxynucleotides inhibit retinal neovascularization in a murine model of proliferative retinopathy. Proc Natl Acad Sci U S A. 1996 May 14; 93(10):4851-6. PMID: 8643492.
    Citations: 67     Fields:    Translation:AnimalsCells
  149. Aiello LP, Pierce EA, Foley ED, Takagi H, Chen H, Riddle L, Ferrara N, King GL, Smith LE. Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins. Proc Natl Acad Sci U S A. 1995 Nov 07; 92(23):10457-61. PMID: 7479819.
    Citations: 248     Fields:    Translation:Animals
  150. Seow WK, Needleman HL, Smith LE, Holtzman D, Najjar S. Enamel hypoplasia, bilateral cataracts, and aqueductal stenosis: a new syndrome? Am J Med Genet. 1995 Sep 25; 58(4):371-3. PMID: 8533849.
    Citations:    Fields:    Translation:Humans
  151. Burns JC, Wright JD, Newburger JW, Schneeberger EE, Mierau GW, Smith LE. Conjunctival biopsy in patients with Kawasaki disease. Pediatr Pathol Lab Med. 1995 Jul-Aug; 15(4):547-53. PMID: 8597841.
    Citations: 1     Fields:    Translation:Humans
  152. Pierce EA, Avery RL, Foley ED, Aiello LP, Smith LE. Vascular endothelial growth factor/vascular permeability factor expression in a mouse model of retinal neovascularization. Proc Natl Acad Sci U S A. 1995 Jan 31; 92(3):905-9. PMID: 7846076.
    Citations: 238     Fields:    Translation:Animals
  153. Wesolowski E, Smith LE. Effect of light on oxygen-induced retinopathy in the mouse. Invest Ophthalmol Vis Sci. 1994 Jan; 35(1):112-9. PMID: 7507905.
    Citations: 5     Fields:    Translation:HumansAnimals
  154. Smith LE, Wesolowski E, McLellan A, Kostyk SK, D'Amato R, Sullivan R, D'Amore PA. Oxygen-induced retinopathy in the mouse. Invest Ophthalmol Vis Sci. 1994 Jan; 35(1):101-11. PMID: 7507904.
    Citations: 509     Fields:    Translation:HumansAnimals
  155. D'Amato R, Wesolowski E, Smith LE. Microscopic visualization of the retina by angiography with high-molecular-weight fluorescein-labeled dextrans in the mouse. Microvasc Res. 1993 Sep; 46(2):135-42. PMID: 7504160.
    Citations: 32     Fields:    Translation:Animals
  156. Smith LE, Sweet E, Freedman S, D'Amore PA. Alterations in endothelial superoxide dismutase levels as a function of growth state in vitro. Invest Ophthalmol Vis Sci. 1992 Jan; 33(1):36-41. PMID: 1730547.
    Citations: 1     Fields:    Translation:AnimalsCells
  157. Smith, LEH, Burns, J. Kawasaki Syndrome in the Eye. Pediatric Infectious Disease Journal. 1989; 8:116-118.
  158. Connolly SE, Hores TA, Smith LE, D'Amore PA. Characterization of vascular development in the mouse retina. Microvasc Res. 1988 Nov; 36(3):275-90. PMID: 2466191.
    Citations: 29     Fields:    Translation:Animals
  159. Hoover DL, Smith LE, Turner SJ, Gelber RD, Sallan SE. Ophthalmic evaluation of survivors of acute lymphoblastic leukemia. Ophthalmology. 1988 Feb; 95(2):151-5. PMID: 3173990.
    Citations: 4     Fields:    Translation:Humans
  160. Sadun, AA, Johnson, DM, Smith, LEH. Neuroanatomy of the human visual system: part II- Retinal projections to the superior colliculus and pulvinar. Neuro-ophthalmology. 1986; 6(6):362-370.
  161. Sadun AA, Schaechter JD, Smith LE. A retinohypothalamic pathway in man: light mediation of circadian rhythms. Brain Res. 1984 Jun 08; 302(2):371-7. PMID: 6733517.
    Citations: 17     Fields:    Translation:HumansCells
  162. Sadun AA, Smith LE, Kenyon KR. Paraphenylenediamine: a new method for tracing human visual pathways. J Neuropathol Exp Neurol. 1983 Mar; 42(2):200-6. PMID: 6827290.
    Citations: 13     Fields:    Translation:HumansCells
  163. Beatty, RM, Sadun, AA, Smith, LEH, Vonsateil, JP, Richardson, EP. Direct demonstration of transsynaptic degeneration in the human visual system. Journal of Neurology Neurosurgery Psychiatry. 1982; 45:143.
  164. Mohr LH, Smith LE, Raftery MA. Alpha-secondary tritium isotope effects in the aqueous hydrolysis of glycopyranosides of N-acetyl-beta-D-glucosamine. Arch Biochem Biophys. 1973 Nov; 159(1):505-11. PMID: 4784470.
    Citations: 1     Fields:    Translation:Cells
  165. Smith LE, Mohr LH, Raftery MA. Mechanism for lysozyme-catalyzed hydrolysis. J Am Chem Soc. 1973 Oct 31; 95(22):7497-7500. PMID: 4201176.
    Citations: 3     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.