Harvard Catalyst Profiles

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Loren David Walensky, M.D.,Ph.D.

Co-Author

This page shows the publications co-authored by Loren Walensky and Gregory Bird.
Connection Strength

8.911
  1. Hydrocarbon-Stitched Peptide Agonists of Glucagon-Like Peptide-1 Receptor. ACS Chem Biol. 2020 06 19; 15(6):1340-1348.
    View in: PubMed
    Score: 0.876
  2. Biophysical determinants for cellular uptake of hydrocarbon-stapled peptide helices. Nat Chem Biol. 2016 10; 12(10):845-52.
    View in: PubMed
    Score: 0.675
  3. Stapled HIV-1 peptides recapitulate antigenic structures and engage broadly neutralizing antibodies. Nat Struct Mol Biol. 2014 Dec; 21(12):1058-67.
    View in: PubMed
    Score: 0.598
  4. Mucosal delivery of a double-stapled RSV peptide prevents nasopulmonary infection. J Clin Invest. 2014 May; 124(5):2113-24.
    View in: PubMed
    Score: 0.573
  5. Hydrocarbon-stapled peptides: principles, practice, and progress. J Med Chem. 2014 Aug 14; 57(15):6275-88.
    View in: PubMed
    Score: 0.569
  6. Distinct BimBH3 (BimSAHB) stapled peptides for structural and cellular studies. ACS Chem Biol. 2014 Mar 21; 9(3):831-7.
    View in: PubMed
    Score: 0.562
  7. Chemical synthesis of hydrocarbon-stapled peptides for protein interaction research and therapeutic targeting. Curr Protoc Chem Biol. 2011 Sep 01; 3(3):99-117.
    View in: PubMed
    Score: 0.478
  8. Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic. Proc Natl Acad Sci U S A. 2010 Aug 10; 107(32):14093-8.
    View in: PubMed
    Score: 0.443
  9. Synthesis and biophysical characterization of stabilized alpha-helices of BCL-2 domains. Methods Enzymol. 2008; 446:369-86.
    View in: PubMed
    Score: 0.371
  10. Targeting a helix-in-groove interaction between E1 and E2 blocks ubiquitin transfer. Nat Chem Biol. 2020 11; 16(11):1218-1226.
    View in: PubMed
    Score: 0.222
  11. A redox switch regulates the structure and function of anti-apoptotic BFL-1. Nat Struct Mol Biol. 2020 09; 27(9):781-789.
    View in: PubMed
    Score: 0.221
  12. Identification of a Covalent Molecular Inhibitor of Anti-apoptotic BFL-1 by Disulfide Tethering. Cell Chem Biol. 2020 06 18; 27(6):647-656.e6.
    View in: PubMed
    Score: 0.218
  13. Precision Targeting of BFL-1/A1 and an ATM Co-dependency in Human Cancer. Cell Rep. 2018 09 25; 24(13):3393-3403.e5.
    View in: PubMed
    Score: 0.195
  14. Dynamic Regulation of Long-Chain Fatty Acid Oxidation by a Noncanonical Interaction between the MCL-1 BH3 Helix and VLCAD. Mol Cell. 2018 03 01; 69(5):729-743.e7.
    View in: PubMed
    Score: 0.187
  15. Crystal Structures of Anti-apoptotic BFL-1 and Its Complex with a Covalent Stapled Peptide Inhibitor. Structure. 2018 01 02; 26(1):153-160.e4.
    View in: PubMed
    Score: 0.185
  16. Challenges in Targeting a Basic Helix-Loop-Helix Transcription Factor with Hydrocarbon-Stapled Peptides. ACS Chem Biol. 2016 11 18; 11(11):3146-3153.
    View in: PubMed
    Score: 0.170
  17. Selective Covalent Targeting of Anti-Apoptotic BFL-1 by Cysteine-Reactive Stapled Peptide Inhibitors. Cell Chem Biol. 2016 Sep 22; 23(9):1123-1134.
    View in: PubMed
    Score: 0.169
  18. Allosteric inhibition of antiapoptotic MCL-1. Nat Struct Mol Biol. 2016 06; 23(6):600-7.
    View in: PubMed
    Score: 0.165
  19. Cellular Uptake and Ultrastructural Localization Underlie the Pro-apoptotic Activity of a Hydrocarbon-stapled BIM BH3 Peptide. ACS Chem Biol. 2015 Sep 18; 10(9):2149-57.
    View in: PubMed
    Score: 0.156
  20. Inhibition of Pro-apoptotic BAX by a noncanonical interaction mechanism. Mol Cell. 2015 Mar 05; 57(5):873-886.
    View in: PubMed
    Score: 0.152
  21. Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices. Proc Natl Acad Sci U S A. 2015 Feb 10; 112(6):1761-6.
    View in: PubMed
    Score: 0.151
  22. Photoreactive stapled peptides to identify and characterize BCL-2 family interaction sites by mass spectrometry. Methods Enzymol. 2014; 544:25-48.
    View in: PubMed
    Score: 0.141
  23. Multimodal interaction with BCL-2 family proteins underlies the proapoptotic activity of PUMA BH3. Chem Biol. 2013 Jul 25; 20(7):888-902.
    View in: PubMed
    Score: 0.136
  24. Direct activation of full-length proapoptotic BAK. Proc Natl Acad Sci U S A. 2013 Mar 12; 110(11):E986-95.
    View in: PubMed
    Score: 0.132
  25. A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers. J Clin Invest. 2012 Jun; 122(6):2018-31.
    View in: PubMed
    Score: 0.126
  26. Photoreactive stapled BH3 peptides to dissect the BCL-2 family interactome. Chem Biol. 2010 Dec 22; 17(12):1325-33.
    View in: PubMed
    Score: 0.114
  27. BH3-triggered structural reorganization drives the activation of proapoptotic BAX. Mol Cell. 2010 Nov 12; 40(3):481-92.
    View in: PubMed
    Score: 0.113
  28. BAX activation is initiated at a novel interaction site. Nature. 2008 Oct 23; 455(7216):1076-81.
    View in: PubMed
    Score: 0.098
  29. Generation of Potent and Stable GLP-1 Analogues Via "Serine Ligation". ACS Chem Biol. 2022 Mar 23.
    View in: PubMed
    Score: 0.062
  30. Glucose metabolism and pyruvate carboxylase enhance glutathione synthesis and restrict oxidative stress in pancreatic islets. Cell Rep. 2021 11 23; 37(8):110037.
    View in: PubMed
    Score: 0.061
  31. Characterizing Native and Hydrocarbon-Stapled Enfuvirtide Conformations with Ion Mobility Mass Spectrometry and Hydrogen-Deuterium Exchange. J Am Soc Mass Spectrom. 2021 Mar 03; 32(3):753-761.
    View in: PubMed
    Score: 0.057
  32. Binding and transport of SFPQ-RNA granules by KIF5A/KLC1 motors promotes axon survival. J Cell Biol. 2021 01 04; 220(1).
    View in: PubMed
    Score: 0.057
  33. Glucose-dependent partitioning of arginine to the urea cycle protects ß-cells from inflammation. Nat Metab. 2020 05; 2(5):432-446.
    View in: PubMed
    Score: 0.055
  34. MDM2 and MDM4 Are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors. Cancer Res. 2019 05 01; 79(9):2404-2414.
    View in: PubMed
    Score: 0.050
  35. Genome-scale CRISPR-Cas9 screen identifies druggable dependencies in TP53 wild-type Ewing sarcoma. J Exp Med. 2018 08 06; 215(8):2137-2155.
    View in: PubMed
    Score: 0.048
  36. Iterative optimization yields Mcl-1-targeting stapled peptides with selective cytotoxicity to Mcl-1-dependent cancer cells. Proc Natl Acad Sci U S A. 2018 01 30; 115(5):E886-E895.
    View in: PubMed
    Score: 0.046
  37. Paclitaxel Reduces Axonal Bclw to Initiate IP3R1-Dependent Axon Degeneration. Neuron. 2017 Oct 11; 96(2):373-386.e6.
    View in: PubMed
    Score: 0.046
  38. Generation of multiple reporter ions from a single isobaric reagent increases multiplexing capacity for quantitative proteomics. Anal Chem. 2015 Oct 06; 87(19):9855-63.
    View in: PubMed
    Score: 0.039
  39. Phospho-BAD BH3 mimicry protects ß cells and restores functional ß cell mass in diabetes. Cell Rep. 2015 Feb 03; 10(4):497-504.
    View in: PubMed
    Score: 0.038
  40. A phospho-BAD BH3 helix activates glucokinase by a mechanism distinct from that of allosteric activators. Nat Struct Mol Biol. 2014 Jan; 21(1):36-42.
    View in: PubMed
    Score: 0.035
  41. Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer. Nat Chem Biol. 2013 Oct; 9(10):643-50.
    View in: PubMed
    Score: 0.034
  42. Targeted disruption of the BCL9/ß-catenin complex inhibits oncogenic Wnt signaling. Sci Transl Med. 2012 Aug 22; 4(148):148ra117.
    View in: PubMed
    Score: 0.032
  43. Characterization of a core fragment of the rhesus monkey TRIM5a protein. BMC Biochem. 2011 Jan 04; 12:1.
    View in: PubMed
    Score: 0.029
  44. Dual role of proapoptotic BAD in insulin secretion and beta cell survival. Nat Med. 2008 Feb; 14(2):144-53.
    View in: PubMed
    Score: 0.023
Connection Strength
The connection strength for co-authors is the sum of the scores for each of their shared publications.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.