Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Loren David Walensky, M.D.,Ph.D.

Other Positions

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01CA233978 (ENGEN, JOHN R) Dec 1, 2019 - Nov 30, 2024
    Conformational Regulation and Therapeutic Targeting of Oncogenic KRAS
    Role: Co-Principal Investigator
  2. R21CA209358 (WALENSKY, LOREN DAVID) Jun 2, 2016 - May 31, 2018
    Biophysical and Mechanistic Determinants for Cancer Cell Import of Hydrocarbon-Stapled Peptides
    Role: Principal Investigator
  3. R35CA197583 (WALENSKY, LOREN DAVID) Aug 10, 2015 - Jul 31, 2028
    Dissecting and Targeting Deregulated Mitochondrial Apoptosis in Human Cancer
    Role: Principal Investigator
  4. R01CA195540 (WALENSKY, LOREN DAVID) Jul 1, 2015 - Jun 30, 2020
    Negative Regulation of Apoptosis by the BH4 Domain of BCL-2 Proteins
    Role: Principal Investigator
  5. R01GM090299 (WALENSKY, LOREN DAVID) Sep 30, 2009 - Aug 31, 2014
    A Lexicon of Stapled Peptide Helices Engineered to Capture the Protein Interactom
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Levine PM, Craven TW, Li X, Balana AT, Bird GH, Godes M, Salveson PJ, Erickson PW, Lamb M, Ahlrichs M, Murphy M, Ogohara C, Said MY, Walensky LD, Pratt MR, Baker D. Generation of Potent and Stable GLP-1 Analogues Via "Serine Ligation". ACS Chem Biol. 2022 Mar 23. PMID: 35319882.
    Citations:    Fields:    
  2. Saleh MN, Patel MR, Bauer TM, Goel S, Falchook GS, Shapiro GI, Chung KY, Infante JR, Conry RM, Rabinowits G, Hong DS, Wang JS, Steidl U, Walensky LD, Naik G, Guerlavais V, Vukovic V, Annis DA, Aivado M, Meric-Bernstam F. Correction: Phase I Trial of ALRN-6924, a Dual Inhibitor of MDMX and MDM2, in Patients with Solid Tumors and Lymphomas Bearing Wild-type TP53. Clin Cancer Res. 2022 Jan 15; 28(2):429. PMID: 35045962.
    Citations:    Fields:    
  3. Fu A, van Rooyen L, Evans L, Armstrong N, Avizonis D, Kin T, Bird GH, Reddy A, Chouchani ET, Liesa-Roig M, Walensky LD, Shapiro AMJ, Danial NN. Glucose metabolism and pyruvate carboxylase enhance glutathione synthesis and restrict oxidative stress in pancreatic islets. Cell Rep. 2021 11 23; 37(8):110037. PMID: 34818536.
    Citations:    Fields:    Translation:HumansAnimalsCells
  4. Bloch NB, Wales TE, Prew MS, Levy HR, Engen JR, Walensky LD. The conformational stability of pro-apoptotic BAX is dictated by discrete residues of the protein core. Nat Commun. 2021 08 13; 12(1):4932. PMID: 34389733.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  5. Stocks BB, Bird GH, Walensky LD, Melanson JE. Characterizing Native and Hydrocarbon-Stapled Enfuvirtide Conformations with Ion Mobility Mass Spectrometry and Hydrogen-Deuterium Exchange. J Am Soc Mass Spectrom. 2021 Mar 03; 32(3):753-761. PMID: 33534566.
    Citations:    Fields:    
  6. Fukuda Y, Pazyra-Murphy MF, Silagi ES, Tasdemir-Yilmaz OE, Li Y, Rose L, Yeoh ZC, Vangos NE, Geffken EA, Seo HS, Adelmant G, Bird GH, Walensky LD, Marto JA, Dhe-Paganon S, Segal RA. Binding and transport of SFPQ-RNA granules by KIF5A/KLC1 motors promotes axon survival. J Cell Biol. 2021 01 04; 220(1). PMID: 33284322.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  7. Cathcart AM, Bird GH, Wales TE, Herce HD, Harvey EP, Hauseman ZJ, Newman CE, Adhikary U, Prew MS, Oo T, Lee S, Engen JR, Walensky LD. Targeting a helix-in-groove interaction between E1 and E2 blocks ubiquitin transfer. Nat Chem Biol. 2020 11; 16(11):1218-1226. PMID: 32807965.
    Citations: 3     Fields:    Translation:HumansCells
  8. Korshavn KJ, Wales TE, Bird GH, Engen JR, Walensky LD. A redox switch regulates the structure and function of anti-apoptotic BFL-1. Nat Struct Mol Biol. 2020 09; 27(9):781-789. PMID: 32661419.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  9. Hauseman ZJ, Harvey EP, Newman CE, Wales TE, Bucci JC, Mintseris J, Schweppe DK, David L, Fan L, Cohen DT, Herce HD, Mourtada R, Ben-Nun Y, Bloch NB, Hansen SB, Wu H, Gygi SP, Engen JR, Walensky LD. Homogeneous Oligomers of Pro-apoptotic BAX Reveal Structural Determinants of Mitochondrial Membrane Permeabilization. Mol Cell. 2020 07 02; 79(1):68-83.e7. PMID: 32533918.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  10. Bird GH, Fu A, Escudero S, Godes M, Opoku-Nsiah K, Wales TE, Cameron MD, Engen JR, Danial NN, Walensky LD. Hydrocarbon-Stitched Peptide Agonists of Glucagon-Like Peptide-1 Receptor. ACS Chem Biol. 2020 06 19; 15(6):1340-1348. PMID: 32348108.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  11. Harvey EP, Hauseman ZJ, Cohen DT, Rettenmaier TJ, Lee S, Huhn AJ, Wales TE, Seo HS, Luccarelli J, Newman CE, Guerra RM, Bird GH, Dhe-Paganon S, Engen JR, Wells JA, Walensky LD. Identification of a Covalent Molecular Inhibitor of Anti-apoptotic BFL-1 by Disulfide Tethering. Cell Chem Biol. 2020 06 18; 27(6):647-656.e6. PMID: 32413285.
    Citations: 4     Fields:    Translation:HumansCells
  12. Fu A, Alvarez-Perez JC, Avizonis D, Kin T, Ficarro SB, Choi DW, Karakose E, Badur MG, Evans L, Rosselot C, Bridon G, Bird GH, Seo HS, Dhe-Paganon S, Kamphorst JJ, Stewart AF, James Shapiro AM, Marto JA, Walensky LD, Jones RG, Garcia-Ocana A, Danial NN. Glucose-dependent partitioning of arginine to the urea cycle protects ß-cells from inflammation. Nat Metab. 2020 05; 2(5):432-446. PMID: 32694660.
    Citations: 3     Fields:    Translation:HumansCells
  13. Ben-Nun Y, Seo HS, Harvey EP, Hauseman ZJ, Wales TE, Newman CE, Cathcart AM, Engen JR, Dhe-Paganon S, Walensky LD. Identification of a Structural Determinant for Selective Targeting of HDMX. Structure. 2020 07 07; 28(7):847-857.e5. PMID: 32359398.
    Citations:    Fields:    Translation:HumansCells
  14. Cohen DT, Wales TE, McHenry MW, Engen JR, Walensky LD. Site-Dependent Cysteine Lipidation Potentiates the Activation of Proapoptotic BAX. Cell Rep. 2020 03 10; 30(10):3229-3239.e6. PMID: 32160532.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  15. Rowell TR, Redd RA, Neuberg DS, Walensky LD. Mind the gap: Expediting gender parity in MD-PhD admissions. JCI Insight. 2020 02 27; 5(4). PMID: 32102982.
    Citations: 1     Fields:    Translation:Humans
  16. Mourtada R, Herce HD, Yin DJ, Moroco JA, Wales TE, Engen JR, Walensky LD. Design of stapled antimicrobial peptides that are stable, nontoxic and kill antibiotic-resistant bacteria in mice. Nat Biotechnol. 2019 10; 37(10):1186-1197. PMID: 31427820.
    Citations: 52     Fields:    Translation:HumansAnimalsCells
  17. Walensky LD. Targeting BAX to drug death directly. Nat Chem Biol. 2019 07; 15(7):657-665. PMID: 31209350.
    Citations: 23     Fields:    Translation:HumansCells
  18. Walensky LD. Cheating Death: New Molecules Block BAX. Trends Mol Med. 2019 04; 25(4):259-261. PMID: 30852140.
    Citations: 1     Fields:    Translation:HumansCells
  19. Howard TP, Arnoff TE, Song MR, Giacomelli AO, Wang X, Hong AL, Dharia NV, Wang S, Vazquez F, Pham MT, Morgan AM, Wachter F, Bird GH, Kugener G, Oberlick EM, Rees MG, Tiv HL, Hwang JH, Walsh KH, Cook A, Krill-Burger JM, Tsherniak A, Gokhale PC, Park PJ, Stegmaier K, Walensky LD, Hahn WC, Roberts CWM. MDM2 and MDM4 Are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors. Cancer Res. 2019 05 01; 79(9):2404-2414. PMID: 30755442.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  20. Guerra RM, Bird GH, Harvey EP, Dharia NV, Korshavn KJ, Prew MS, Stegmaier K, Walensky LD. Precision Targeting of BFL-1/A1 and an ATM Co-dependency in Human Cancer. Cell Rep. 2018 09 25; 24(13):3393-3403.e5. PMID: 30257201.
    Citations: 9     Fields:    Translation:HumansCells
  21. Stolte B, Iniguez AB, Dharia NV, Robichaud AL, Conway AS, Morgan AM, Alexe G, Schauer NJ, Liu X, Bird GH, Tsherniak A, Vazquez F, Buhrlage SJ, Walensky LD, Stegmaier K. Genome-scale CRISPR-Cas9 screen identifies druggable dependencies in TP53 wild-type Ewing sarcoma. J Exp Med. 2018 08 06; 215(8):2137-2155. PMID: 30045945.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  22. Escudero S, Zaganjor E, Lee S, Mill CP, Morgan AM, Crawford EB, Chen J, Wales TE, Mourtada R, Luccarelli J, Bird GH, Steidl U, Engen JR, Haigis MC, Opferman JT, Walensky LD. Dynamic Regulation of Long-Chain Fatty Acid Oxidation by a Noncanonical Interaction between the MCL-1 BH3 Helix and VLCAD. Mol Cell. 2018 03 01; 69(5):729-743.e7. PMID: 29499131.
    Citations: 21     Fields:    Translation:AnimalsCells
  23. Rezaei Araghi R, Bird GH, Ryan JA, Jenson JM, Godes M, Pritz JR, Grant RA, Letai A, Walensky LD, Keating AE. Iterative optimization yields Mcl-1-targeting stapled peptides with selective cytotoxicity to Mcl-1-dependent cancer cells. Proc Natl Acad Sci U S A. 2018 01 30; 115(5):E886-E895. PMID: 29339518.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  24. Harvey EP, Seo HS, Guerra RM, Bird GH, Dhe-Paganon S, Walensky LD. Crystal Structures of Anti-apoptotic BFL-1 and Its Complex with a Covalent Stapled Peptide Inhibitor. Structure. 2018 01 02; 26(1):153-160.e4. PMID: 29276033.
    Citations: 17     Fields:    Translation:HumansCells
  25. Pease-Raissi SE, Pazyra-Murphy MF, Li Y, Wachter F, Fukuda Y, Fenstermacher SJ, Barclay LA, Bird GH, Walensky LD, Segal RA. Paclitaxel Reduces Axonal Bclw to Initiate IP3R1-Dependent Axon Degeneration. Neuron. 2017 Oct 11; 96(2):373-386.e6. PMID: 29024661.
    Citations: 35     Fields:    Translation:AnimalsCells
  26. Reyna DE, Garner TP, Lopez A, Kopp F, Choudhary GS, Sridharan A, Narayanagari SR, Mitchell K, Dong B, Bartholdy BA, Walensky LD, Verma A, Steidl U, Gavathiotis E. Direct Activation of BAX by BTSA1 Overcomes Apoptosis Resistance in Acute Myeloid Leukemia. Cancer Cell. 2017 10 09; 32(4):490-505.e10. PMID: 29017059.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  27. Wu X, Zhang LS, Toombs J, Kuo YC, Piazza JT, Tuladhar R, Barrett Q, Fan CW, Zhang X, Walensky LD, Kool M, Cheng SY, Brekken R, Opferman JT, Green DR, Moldoveanu T, Lum L. Extra-mitochondrial prosurvival BCL-2 proteins regulate gene transcription by inhibiting the SUFU tumour suppressor. Nat Cell Biol. 2017 Oct; 19(10):1226-1236. PMID: 28945232.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  28. Pritz JR, Wachter F, Lee S, Luccarelli J, Wales TE, Cohen DT, Coote P, Heffron GJ, Engen JR, Massefski W, Walensky LD. Allosteric sensitization of proapoptotic BAX. Nat Chem Biol. 2017 Sep; 13(9):961-967. PMID: 28692068.
    Citations: 17     Fields:    Translation:HumansCells
  29. Cerqueira DM, Bodnar AJ, Phua YL, Freer R, Hemker SL, Walensky LD, Hukriede NA, Ho J. Bim gene dosage is critical in modulating nephron progenitor survival in the absence of microRNAs during kidney development. FASEB J. 2017 08; 31(8):3540-3554. PMID: 28446592.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  30. Wachter F, Morgan AM, Godes M, Mourtada R, Bird GH, Walensky LD. Mechanistic validation of a clinical lead stapled peptide that reactivates p53 by dual HDM2 and HDMX targeting. Oncogene. 2017 04; 36(15):2184-2190. PMID: 27721413.
    Citations: 14     Fields:    Translation:HumansCells
  31. Edwards AL, Meijer DH, Guerra RM, Molenaar RJ, Alberta JA, Bernal F, Bird GH, Stiles CD, Walensky LD. Challenges in Targeting a Basic Helix-Loop-Helix Transcription Factor with Hydrocarbon-Stapled Peptides. ACS Chem Biol. 2016 11 18; 11(11):3146-3153. PMID: 27643505.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  32. Huhn AJ, Guerra RM, Harvey EP, Bird GH, Walensky LD. Selective Covalent Targeting of Anti-Apoptotic BFL-1 by Cysteine-Reactive Stapled Peptide Inhibitors. Cell Chem Biol. 2016 Sep 22; 23(9):1123-1134. PMID: 27617850.
    Citations: 26     Fields:    Translation:HumansCells
  33. Bird GH, Mazzola E, Opoku-Nsiah K, Lammert MA, Godes M, Neuberg DS, Walensky LD. Biophysical determinants for cellular uptake of hydrocarbon-stapled peptide helices. Nat Chem Biol. 2016 10; 12(10):845-52. PMID: 27547919.
    Citations: 58     Fields:    Translation:AnimalsCells
  34. Lee S, Wales TE, Escudero S, Cohen DT, Luccarelli J, Gallagher CG, Cohen NA, Huhn AJ, Bird GH, Engen JR, Walensky LD. Allosteric inhibition of antiapoptotic MCL-1. Nat Struct Mol Biol. 2016 06; 23(6):600-7. PMID: 27159560.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  35. Carpio MA, Michaud M, Zhou W, Fisher JK, Walensky LD, Katz SG. Reply to Fernandez-Marrero et al.: Role of BOK at the intersection of endoplasmic reticulum stress and apoptosis regulation. Proc Natl Acad Sci U S A. 2016 Feb 02; 113(5):E494-5. PMID: 26811485.
    Citations: 7     Fields:    Translation:AnimalsCells
  36. Kim KH, Kim W, Howard TP, Vazquez F, Tsherniak A, Wu JN, Wang W, Haswell JR, Walensky LD, Hahn WC, Orkin SH, Roberts CW. SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2. Nat Med. 2015 Dec; 21(12):1491-6. PMID: 26552009.
    Citations: 164     Fields:    Translation:HumansAnimalsCells
  37. Braun CR, Bird GH, Wühr M, Erickson BK, Rad R, Walensky LD, Gygi SP, Haas W. Generation of multiple reporter ions from a single isobaric reagent increases multiplexing capacity for quantitative proteomics. Anal Chem. 2015 Oct 06; 87(19):9855-63. PMID: 26308379.
    Citations: 13     Fields:    
  38. Edwards AL, Wachter F, Lammert M, Huhn AJ, Luccarelli J, Bird GH, Walensky LD. Cellular Uptake and Ultrastructural Localization Underlie the Pro-apoptotic Activity of a Hydrocarbon-stapled BIM BH3 Peptide. ACS Chem Biol. 2015 Sep 18; 10(9):2149-57. PMID: 26151238.
    Citations: 17     Fields:    Translation:AnimalsCells
  39. Zhang T, Barclay L, Walensky LD, Saghatelian A. Regulation of mitochondrial ceramide distribution by members of the BCL-2 family. J Lipid Res. 2015 Aug; 56(8):1501-10. PMID: 26059977.
    Citations: 8     Fields:    Translation:AnimalsCells
  40. Carpio MA, Michaud M, Zhou W, Fisher JK, Walensky LD, Katz SG. BCL-2 family member BOK promotes apoptosis in response to endoplasmic reticulum stress. Proc Natl Acad Sci U S A. 2015 Jun 09; 112(23):7201-6. PMID: 26015568.
    Citations: 52     Fields:    Translation:AnimalsCells
  41. Zhang T, Walensky LD, Saghatelian A. A nonapoptotic role for BAX and BAK in eicosanoid metabolism. ACS Chem Biol. 2015 Jun 19; 10(6):1398-403. PMID: 25815636.
    Citations: 1     Fields:    Translation:AnimalsCells
  42. Barclay LA, Wales TE, Garner TP, Wachter F, Lee S, Guerra RM, Stewart ML, Braun CR, Bird GH, Gavathiotis E, Engen JR, Walensky LD. Inhibition of Pro-apoptotic BAX by a noncanonical interaction mechanism. Mol Cell. 2015 Mar 05; 57(5):873-886. PMID: 25684204.
    Citations: 65     Fields:    Translation:HumansCells
  43. Ljubicic S, Polak K, Fu A, Wiwczar J, Szlyk B, Chang Y, Alvarez-Perez JC, Bird GH, Walensky LD, Garcia-Ocaña A, Danial NN. Phospho-BAD BH3 mimicry protects ß cells and restores functional ß cell mass in diabetes. Cell Rep. 2015 Feb 03; 10(4):497-504. PMID: 25640178.
    Citations: 14     Fields:    Translation:AnimalsCells
  44. Leshchiner ES, Parkhitko A, Bird GH, Luccarelli J, Bellairs JA, Escudero S, Opoku-Nsiah K, Godes M, Perrimon N, Walensky LD. Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices. Proc Natl Acad Sci U S A. 2015 Feb 10; 112(6):1761-6. PMID: 25624485.
    Citations: 56     Fields:    Translation:HumansAnimalsCells
  45. Perry JA, Kiezun A, Tonzi P, Van Allen EM, Carter SL, Baca SC, Cowley GS, Bhatt AS, Rheinbay E, Pedamallu CS, Helman E, Taylor-Weiner A, McKenna A, DeLuca DS, Lawrence MS, Ambrogio L, Sougnez C, Sivachenko A, Walensky LD, Wagle N, Mora J, de Torres C, Lavarino C, Dos Santos Aguiar S, Yunes JA, Brandalise SR, Mercado-Celis GE, Melendez-Zajgla J, Cárdenas-Cardós R, Velasco-Hidalgo L, Roberts CW, Garraway LA, Rodriguez-Galindo C, Gabriel SB, Lander ES, Golub TR, Orkin SH, Getz G, Janeway KA. Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma. Proc Natl Acad Sci U S A. 2014 Dec 23; 111(51):E5564-73. PMID: 25512523.
    Citations: 174     Fields:    Translation:HumansCells
  46. Bird GH, Irimia A, Ofek G, Kwong PD, Wilson IA, Walensky LD. Stapled HIV-1 peptides recapitulate antigenic structures and engage broadly neutralizing antibodies. Nat Struct Mol Biol. 2014 Dec; 21(12):1058-67. PMID: 25420104.
    Citations: 32     Fields:    Translation:HumansCells
  47. Bird GH, Boyapalle S, Wong T, Opoku-Nsiah K, Bedi R, Crannell WC, Perry AF, Nguyen H, Sampayo V, Devareddy A, Mohapatra S, Mohapatra SS, Walensky LD. Mucosal delivery of a double-stapled RSV peptide prevents nasopulmonary infection. J Clin Invest. 2014 May; 124(5):2113-24. PMID: 24743147.
    Citations: 21     Fields:    Translation:AnimalsCells
  48. Walensky LD, Bird GH. Hydrocarbon-stapled peptides: principles, practice, and progress. J Med Chem. 2014 Aug 14; 57(15):6275-88. PMID: 24601557.
    Citations: 207     Fields:    Translation:HumansAnimalsCells
  49. Reynolds C, Roderick JE, LaBelle JL, Bird G, Mathieu R, Bodaar K, Colon D, Pyati U, Stevenson KE, Qi J, Harris M, Silverman LB, Sallan SE, Bradner JE, Neuberg DS, Look AT, Walensky LD, Kelliher MA, Gutierrez A. Repression of BIM mediates survival signaling by MYC and AKT in high-risk T-cell acute lymphoblastic leukemia. Leukemia. 2014 Sep; 28(9):1819-27. PMID: 24552990.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  50. Bird GH, Gavathiotis E, LaBelle JL, Katz SG, Walensky LD. Distinct BimBH3 (BimSAHB) stapled peptides for structural and cellular studies. ACS Chem Biol. 2014 Mar 21; 9(3):831-7. PMID: 24358963.
    Citations: 37     Fields:    Translation:HumansAnimals
  51. Lee S, Braun CR, Bird GH, Walensky LD. Photoreactive stapled peptides to identify and characterize BCL-2 family interaction sites by mass spectrometry. Methods Enzymol. 2014; 544:25-48. PMID: 24974285.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  52. Katz SG, Labelle JL, Meng H, Valeriano RP, Fisher JK, Sun H, Rodig SJ, Kleinstein SH, Walensky LD. Mantle cell lymphoma in cyclin D1 transgenic mice with Bim-deficient B cells. Blood. 2014 Feb 06; 123(6):884-93. PMID: 24352880.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  53. Szlyk B, Braun CR, Ljubicic S, Patton E, Bird GH, Osundiji MA, Matschinsky FM, Walensky LD, Danial NN. A phospho-BAD BH3 helix activates glucokinase by a mechanism distinct from that of allosteric activators. Nat Struct Mol Biol. 2014 Jan; 21(1):36-42. PMID: 24317490.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  54. Kim W, Bird GH, Neff T, Guo G, Kerenyi MA, Walensky LD, Orkin SH. Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer. Nat Chem Biol. 2013 Oct; 9(10):643-50. PMID: 23974116.
    Citations: 146     Fields:    Translation:Humans
  55. Edwards AL, Gavathiotis E, LaBelle JL, Braun CR, Opoku-Nsiah KA, Bird GH, Walensky LD. Multimodal interaction with BCL-2 family proteins underlies the proapoptotic activity of PUMA BH3. Chem Biol. 2013 Jul 25; 20(7):888-902. PMID: 23890007.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  56. Varadarajan S, Vogler M, Butterworth M, Dinsdale D, Walensky LD, Cohen GM. Evaluation and critical assessment of putative MCL-1 inhibitors. Cell Death Differ. 2013 Nov; 20(11):1475-84. PMID: 23832116.
    Citations: 52     Fields:    Translation:HumansCells
  57. Walensky LD. Direct BAKtivation. Nat Struct Mol Biol. 2013 May; 20(5):536-8. PMID: 23649360.
    Citations: 4     Fields:    Translation:Humans
  58. Hilgendorf KI, Leshchiner ES, Nedelcu S, Maynard MA, Calo E, Ianari A, Walensky LD, Lees JA. The retinoblastoma protein induces apoptosis directly at the mitochondria. Genes Dev. 2013 May 01; 27(9):1003-15. PMID: 23618872.
    Citations: 62     Fields:    Translation:HumansAnimalsCells
  59. Walensky LD. Playing fullBAK. Cell Cycle. 2013 May 01; 12(9):1333-4. PMID: 23588072.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  60. Walensky LD. Protein-protein interactions: A PUMA mechanism unfolds. Nat Chem Biol. 2013 Mar; 9(3):141-3. PMID: 23416398.
    Citations: 2     Fields:    Translation:HumansCells
  61. Leshchiner ES, Braun CR, Bird GH, Walensky LD. Direct activation of full-length proapoptotic BAK. Proc Natl Acad Sci U S A. 2013 Mar 12; 110(11):E986-95. PMID: 23404709.
    Citations: 80     Fields:    Translation:HumansAnimalsCells
  62. Cohen NA, Stewart ML, Gavathiotis E, Tepper JL, Bruekner SR, Koss B, Opferman JT, Walensky LD. A competitive stapled peptide screen identifies a selective small molecule that overcomes MCL-1-dependent leukemia cell survival. Chem Biol. 2012 Sep 21; 19(9):1175-86. PMID: 22999885.
    Citations: 66     Fields:    Translation:Humans
  63. Katz SG, Fisher JK, Correll M, Bronson RT, Ligon KL, Walensky LD. Brain and testicular tumors in mice with progenitor cells lacking BAX and BAK. Oncogene. 2013 Aug 29; 32(35):4078-85. PMID: 22986529.
    Citations: 4     Fields:    Translation:AnimalsCells
  64. Takada K, Zhu D, Bird GH, Sukhdeo K, Zhao JJ, Mani M, Lemieux M, Carrasco DE, Ryan J, Horst D, Fulciniti M, Munshi NC, Xu W, Kung AL, Shivdasani RA, Walensky LD, Carrasco DR. Targeted disruption of the BCL9/ß-catenin complex inhibits oncogenic Wnt signaling. Sci Transl Med. 2012 Aug 22; 4(148):148ra117. PMID: 22914623.
    Citations: 112     Fields:    Translation:HumansAnimalsCells
  65. Walensky LD. Interview with Loren D Walensky. Future Med Chem. 2012 Aug; 4(12):1537-9. PMID: 22917243.
    Citations:    Fields:    Translation:HumansCells
  66. Walensky LD. Stemming danger with Golgified BAX. Mol Cell. 2012 Jun 08; 46(5):554-6. PMID: 22681883.
    Citations: 1     Fields:    
  67. Gavathiotis E, Reyna DE, Bellairs JA, Leshchiner ES, Walensky LD. Direct and selective small-molecule activation of proapoptotic BAX. Nat Chem Biol. 2012 Jul; 8(7):639-45. PMID: 22634637.
    Citations: 64     Fields:    Translation:AnimalsCells
  68. LaBelle JL, Katz SG, Bird GH, Gavathiotis E, Stewart ML, Lawrence C, Fisher JK, Godes M, Pitter K, Kung AL, Walensky LD. A stapled BIM peptide overcomes apoptotic resistance in hematologic cancers. J Clin Invest. 2012 Jun; 122(6):2018-31. PMID: 22622039.
    Citations: 93     Fields:    Translation:HumansAnimalsCells
  69. Walensky LD. From mitochondrial biology to magic bullet: navitoclax disarms BCL-2 in chronic lymphocytic leukemia. J Clin Oncol. 2012 Feb 10; 30(5):554-7. PMID: 22184389.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  70. Walensky LD, Gavathiotis E. BAX unleashed: the biochemical transformation of an inactive cytosolic monomer into a toxic mitochondrial pore. Trends Biochem Sci. 2011 Dec; 36(12):642-52. PMID: 21978892.
    Citations: 86     Fields:    Translation:HumansAnimalsCells
  71. Bird GH, Crannell WC, Walensky LD. Chemical synthesis of hydrocarbon-stapled peptides for protein interaction research and therapeutic targeting. Curr Protoc Chem Biol. 2011 Sep 01; 3(3):99-117. PMID: 23801563.
    Citations: 35     Fields:    
  72. Gavathiotis E, Walensky LD. Tracking BAX once its trigger is pulled. Cell Cycle. 2011 Mar 15; 10(6):868-70. PMID: 21325897.
    Citations: 5     Fields:    Translation:Cells
  73. Kar AK, Mao Y, Bird G, Walensky L, Sodroski J. Characterization of a core fragment of the rhesus monkey TRIM5a protein. BMC Biochem. 2011 Jan 04; 12:1. PMID: 21205312.
    Citations: 6     Fields:    Translation:AnimalsCells
  74. Braun CR, Mintseris J, Gavathiotis E, Bird GH, Gygi SP, Walensky LD. Photoreactive stapled BH3 peptides to dissect the BCL-2 family interactome. Chem Biol. 2010 Dec 22; 17(12):1325-33. PMID: 21168768.
    Citations: 20     Fields:    Translation:HumansCells
  75. Bernal F, Wade M, Godes M, Davis TN, Whitehead DG, Kung AL, Wahl GM, Walensky LD. A stapled p53 helix overcomes HDMX-mediated suppression of p53. Cancer Cell. 2010 Nov 16; 18(5):411-22. PMID: 21075307.
    Citations: 122     Fields:    Translation:HumansAnimalsCells
  76. Gavathiotis E, Reyna DE, Davis ML, Bird GH, Walensky LD. BH3-triggered structural reorganization drives the activation of proapoptotic BAX. Mol Cell. 2010 Nov 12; 40(3):481-92. PMID: 21070973.
    Citations: 151     Fields:    Translation:HumansCells
  77. Bird GH, Madani N, Perry AF, Princiotto AM, Supko JG, He X, Gavathiotis E, Sodroski JG, Walensky LD. Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic. Proc Natl Acad Sci U S A. 2010 Aug 10; 107(32):14093-8. PMID: 20660316.
    Citations: 94     Fields:    Translation:Humans
  78. Stewart ML, Fire E, Keating AE, Walensky LD. The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer. Nat Chem Biol. 2010 Aug; 6(8):595-601. PMID: 20562877.
    Citations: 165     Fields:    Translation:HumansCells
  79. Gavathiotis E, Suzuki M, Davis ML, Pitter K, Bird GH, Katz SG, Tu HC, Kim H, Cheng EH, Tjandra N, Walensky LD. BAX activation is initiated at a novel interaction site. Nature. 2008 Oct 23; 455(7216):1076-81. PMID: 18948948.
    Citations: 332     Fields:    Translation:HumansAnimalsCells
  80. Danial NN, Walensky LD, Zhang CY, Choi CS, Fisher JK, Molina AJ, Datta SR, Pitter KL, Bird GH, Wikstrom JD, Deeney JT, Robertson K, Morash J, Kulkarni A, Neschen S, Kim S, Greenberg ME, Corkey BE, Shirihai OS, Shulman GI, Lowell BB, Korsmeyer SJ. Dual role of proapoptotic BAD in insulin secretion and beta cell survival. Nat Med. 2008 Feb; 14(2):144-53. PMID: 18223655.
    Citations: 136     Fields:    Translation:HumansAnimalsCells
  81. Pitter K, Bernal F, Labelle J, Walensky LD. Dissection of the BCL-2 family signaling network with stabilized alpha-helices of BCL-2 domains. Methods Enzymol. 2008; 446:387-408. PMID: 18603135.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  82. Bird GH, Bernal F, Pitter K, Walensky LD. Synthesis and biophysical characterization of stabilized alpha-helices of BCL-2 domains. Methods Enzymol. 2008; 446:369-86. PMID: 18603134.
    Citations: 57     Fields:    Translation:Cells
  83. Verdine GL, Walensky LD. The challenge of drugging undruggable targets in cancer: lessons learned from targeting BCL-2 family members. Clin Cancer Res. 2007 Dec 15; 13(24):7264-70. PMID: 18094406.
    Citations: 144     Fields:    Translation:HumansAnimalsCells
  84. Bernal F, Tyler AF, Korsmeyer SJ, Walensky LD, Verdine GL. Reactivation of the p53 tumor suppressor pathway by a stapled p53 peptide. J Am Chem Soc. 2007 Mar 07; 129(9):2456-7. PMID: 17284038.
    Citations: 170     Fields:    Translation:HumansCells
  85. Walensky LD, Pitter K, Morash J, Oh KJ, Barbuto S, Fisher J, Smith E, Verdine GL, Korsmeyer SJ. A stapled BID BH3 helix directly binds and activates BAX. Mol Cell. 2006 Oct 20; 24(2):199-210. PMID: 17052454.
    Citations: 171     Fields:    Translation:HumansCells
  86. Oh KJ, Barbuto S, Pitter K, Morash J, Walensky LD, Korsmeyer SJ. A membrane-targeted BID BCL-2 homology 3 peptide is sufficient for high potency activation of BAX in vitro. J Biol Chem. 2006 Dec 01; 281(48):36999-7008. PMID: 16987815.
    Citations: 36     Fields:    Translation:HumansCells
  87. Walensky LD. BCL-2 in the crosshairs: tipping the balance of life and death. Cell Death Differ. 2006 Aug; 13(8):1339-50. PMID: 16763614.
    Citations: 87     Fields:    Translation:HumansAnimalsCells
  88. Walensky LD, Kung AL, Escher I, Malia TJ, Barbuto S, Wright RD, Wagner G, Verdine GL, Korsmeyer SJ. Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix. Science. 2004 Sep 03; 305(5689):1466-70. PMID: 15353804.
    Citations: 424     Fields:    Translation:HumansAnimalsCells
  89. MacGinnitie AJ, Walensky LD, Turvey SE, Orange JS, Bonilla FA, Silverman LB, Oettgen H. Management of an anaphylactoid reaction to methotrexate with a stepwise graded challenge. Pediatr Allergy Immunol. 2003 Oct; 14(5):409-11. PMID: 14641613.
    Citations: 3     Fields:    Translation:Humans
  90. Ramez M, Blot-Chabaud M, Cluzeaud F, Chanan S, Patterson M, Walensky LD, Marfatia S, Baines AJ, Chasis JA, Conboy JG, Mohandas N, Gascard P. Distinct distribution of specific members of protein 4.1 gene family in the mouse nephron. Kidney Int. 2003 Apr; 63(4):1321-37. PMID: 12631349.
    Citations: 25     Fields:    Translation:AnimalsCells
  91. Letai A, Bassik MC, Walensky LD, Sorcinelli MD, Weiler S, Korsmeyer SJ. Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics. Cancer Cell. 2002 Sep; 2(3):183-92. PMID: 12242151.
    Citations: 597     Fields:    Translation:HumansAnimalsCells
  92. Shen L, Liang F, Walensky LD, Huganir RL. Regulation of AMPA receptor GluR1 subunit surface expression by a 4. 1N-linked actin cytoskeletal association. J Neurosci. 2000 Nov 01; 20(21):7932-40. PMID: 11050113.
    Citations: 129     Fields:    Translation:HumansAnimalsCells
  93. Parra M, Gascard P, Walensky LD, Gimm JA, Blackshaw S, Chan N, Takakuwa Y, Berger T, Lee G, Chasis JA, Snyder SH, Mohandas N, Conboy JG. Molecular and functional characterization of protein 4.1B, a novel member of the protein 4.1 family with high level, focal expression in brain. J Biol Chem. 2000 Feb 04; 275(5):3247-55. PMID: 10652311.
    Citations: 53     Fields:    Translation:AnimalsCells
  94. Ye K, Compton DA, Lai MM, Walensky LD, Snyder SH. Protein 4.1N binding to nuclear mitotic apparatus protein in PC12 cells mediates the antiproliferative actions of nerve growth factor. J Neurosci. 1999 Dec 15; 19(24):10747-56. PMID: 10594058.
    Citations: 24     Fields:    Translation:AnimalsCells
  95. Walensky LD, Blackshaw S, Liao D, Watkins CC, Weier HU, Parra M, Huganir RL, Conboy JG, Mohandas N, Snyder SH. A novel neuron-enriched homolog of the erythrocyte membrane cytoskeletal protein 4.1. J Neurosci. 1999 Aug 01; 19(15):6457-67. PMID: 10414974.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  96. Gascard P, Nunomura W, Lee G, Walensky LD, Krauss SW, Takakuwa Y, Chasis JA, Mohandas N, Conboy JG. Deciphering the nuclear import pathway for the cytoskeletal red cell protein 4.1R. Mol Biol Cell. 1999 Jun; 10(6):1783-98. PMID: 10359596.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  97. Shi ZT, Afzal V, Coller B, Patel D, Chasis JA, Parra M, Lee G, Paszty C, Stevens M, Walensky L, Peters LL, Mohandas N, Rubin E, Conboy JG. Protein 4.1R-deficient mice are viable but have erythroid membrane skeleton abnormalities. J Clin Invest. 1999 Feb; 103(3):331-40. PMID: 9927493.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  98. Peters LL, Weier HU, Walensky LD, Snyder SH, Parra M, Mohandas N, Conboy JG. Four paralogous protein 4.1 genes map to distinct chromosomes in mouse and human. Genomics. 1998 Dec 01; 54(2):348-50. PMID: 9828140.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  99. Walensky LD, Shi ZT, Blackshaw S, DeVries AC, Demas GE, Gascard P, Nelson RJ, Conboy JG, Rubin EM, Snyder SH, Mohandas N. Neurobehavioral deficits in mice lacking the erythrocyte membrane cytoskeletal protein 4.1. Curr Biol. 1998 Nov 19; 8(23):1269-72. PMID: 9822582.
    Citations: 9     Fields:    Translation:AnimalsCells
  100. Walensky LD, Dawson TM, Steiner JP, Sabatini DM, Suarez JD, Klinefelter GR, Snyder SH. The 12 kD FK 506 binding protein FKBP12 is released in the male reproductive tract and stimulates sperm motility. Mol Med. 1998 Aug; 4(8):502-14. PMID: 9742506.
    Citations: 6     Fields:    Translation:AnimalsCells
  101. Walensky LD, Ruat M, Bakin RE, Blackshaw S, Ronnett GV, Snyder SH. Two novel odorant receptor families expressed in spermatids undergo 5'-splicing. J Biol Chem. 1998 Apr 17; 273(16):9378-87. PMID: 9545261.
    Citations: 17     Fields:    Translation:AnimalsCells
  102. Parra M, Gascard P, Walensky LD, Snyder SH, Mohandas N, Conboy JG. Cloning and characterization of 4.1G (EPB41L2), a new member of the skeletal protein 4.1 (EPB41) gene family. Genomics. 1998 Apr 15; 49(2):298-306. PMID: 9598318.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  103. Walensky LD, Gascard P, Fields ME, Blackshaw S, Conboy JG, Mohandas N, Snyder SH. The 13-kD FK506 binding protein, FKBP13, interacts with a novel homologue of the erythrocyte membrane cytoskeletal protein 4.1. J Cell Biol. 1998 Apr 06; 141(1):143-53. PMID: 9531554.
    Citations: 38     Fields:    Translation:AnimalsCells
  104. Walensky LD, Snyder SH. Inositol 1,4,5-trisphosphate receptors selectively localized to the acrosomes of mammalian sperm. J Cell Biol. 1995 Aug; 130(4):857-69. PMID: 7642703.
    Citations: 42     Fields:    Translation:AnimalsCells
  105. Cameron AM, Steiner JP, Sabatini DM, Kaplin AI, Walensky LD, Snyder SH. Immunophilin FK506 binding protein associated with inositol 1,4,5-trisphosphate receptor modulates calcium flux. Proc Natl Acad Sci U S A. 1995 Feb 28; 92(5):1784-8. PMID: 7533300.
    Citations: 63     Fields:    Translation:AnimalsCells
  106. Walensky LD, Roskams AJ, Lefkowitz RJ, Snyder SH, Ronnett GV. Odorant receptors and desensitization proteins colocalize in mammalian sperm. Mol Med. 1995 Jan; 1(2):130-41. PMID: 8529092.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  107. Walensky LD, Coffey DS, Chen TH, Wu TC, Pasternack GR. A novel M(r) 32,000 nuclear phosphoprotein is selectively expressed in cells competent for self-renewal. Cancer Res. 1993 Oct 01; 53(19):4720-6. PMID: 7691403.
    Citations: 16     Fields:    Translation:HumansAnimals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.