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Hanno Reinhard Hock, Ph.D., M.D.

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Mentoring
The role of TEL in B lymphocyte development and TEL-AML1-associated pediatric ALL.
Summer, 06/19/06 - 08/11/06

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01CA122726 (HOCK, HANNO R) Apr 1, 2007 - Sep 29, 2011
    NIH/NCI
    Function of zinc-finger transcription factor Gfi-1 in hematopoietic stem cells
    Role: Principal Investigator
  2. K08CA096701 (HOCK, HANNO R) Jul 17, 2002 - Oct 17, 2005
    NIH/NCI
    Recreating Childhood Leukemia in Mice
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Venkataraman V, Casey KS, Onozato M, Cin PD, Nardi V, Amrein PC, Bergeron MK, Brunner AM, Fathi AT, Foster JE, Moran J, Graubert TA, Hock H, Hunnewell C, Frigault MJ, McAfee S, Hobbs GS. Long: molecular tracking of CML with bilineal inv(16) myeloid and del(9) lymphoid blast crisis and durable response to CD19-directed CAR-T therapy. Leukemia. 2020 Jul 16. PMID: 32678290.
    Citations:    
  2. Nardi V, Ku N, Frigault MJ, Dubuc AM, Tsai HK, Amrein PC, Hobbs GS, Brunner AM, Narayan R, Burke ME, Foster J, Dal Cin P, Maus MV, Fathi AT, Hock H. Clinical response to larotrectinib in adult Philadelphia chromosome-like ALL with cryptic ETV6-NTRK3 rearrangement. Blood Adv. 2020 Jan 14; 4(1):106-111. PMID: 31905241.
    Citations:    
  3. Narayan R, Blonquist TM, Emadi A, Hasserjian RP, Burke M, Lescinskas C, Neuberg DS, Brunner AM, Hobbs G, Hock H, McAfee SL, Chen YB, Attar E, Graubert TA, Bertoli C, Moran JA, Bergeron MK, Foster JE, Ramos AY, Som TT, Vartanian MK, Story JL, McGregor K, Macrae M, Behnan T, Wey MC, Rae J, Preffer FI, Lesho P, Duong VH, Mann ML, Ballen KK, Connolly C, Amrein PC, Fathi AT. A phase 1 study of the antibody-drug conjugate brentuximab vedotin with re-induction chemotherapy in patients with CD30-expressing relapsed/refractory acute myeloid leukemia. Cancer. 2020 Mar 15; 126(6):1264-1273. PMID: 31860140.
    Citations:    
  4. Brunner AM, Blonquist TM, DeAngelo DJ, McMasters M, Fell G, Hermance NM, Winer ES, Lindsley RC, Hobbs GS, Amrein PC, Hock HR, Steensma DP, Garcia JS, Luskin MR, Stone RM, Ballen KK, Rosenblatt J, Avigan D, Nahas MR, Mendez LM, McAfee SL, Moran JA, Bergeron M, Foster J, Bertoli C, Manning AL, McGregor KL, Fishman KM, Kuo FC, Baltay MT, Macrae M, Burke M, Behnan T, Wey MC, Som TT, Ramos AY, Rae J, Lombardi Story J, Nelson N, Logan E, Connolly C, Neuberg DS, Chen YB, Graubert TA, Fathi AT. Alisertib plus induction chemotherapy in previously untreated patients with high-risk, acute myeloid leukaemia: a single-arm, phase 2 trial. Lancet Haematol. 2020 Feb; 7(2):e122-e133. PMID: 31837959.
    Citations:    
  5. Brumbaugh J, Kim IS, Ji F, Huebner AJ, Di Stefano B, Schwarz BA, Charlton J, Coffey A, Choi J, Walsh RM, Schindler JW, Anselmo A, Meissner A, Sadreyev RI, Bernstein BE, Hock H, Hochedlinger K. Inducible histone K-to-M mutations are dynamic tools to probe the physiological role of site-specific histone methylation in vitro and in vivo. Nat Cell Biol. 2019 11; 21(11):1449-1461. PMID: 31659274.
    Citations:    
  6. Alsufyani F, Mattoo H, Zhou D, Cariappa A, Van Buren D, Hock H, Avruch J, Pillai S. The Mst1 Kinase Is Required for Follicular B Cell Homing and B-1 B Cell Development. Front Immunol. 2018; 9:2393. PMID: 30386341.
    Citations:    
  7. Dowling MR, Li S, Dey BR, McAfee SL, Hock HR, Spitzer TR, Chen YB, Ballen KK. Neurologic complications after allogeneic hematopoietic stem cell transplantation: risk factors and impact. Bone Marrow Transplant. 2018 02; 53(2):199-206. PMID: 29131150.
    Citations:    Fields:    
  8. Hock H, Shimamura A. ETV6 in hematopoiesis and leukemia predisposition. Semin Hematol. 2017 04; 54(2):98-104. PMID: 28637624.
    Citations: 1     Fields:    Translation:Humans
  9. Foudi A, Kramer DJ, Qin J, Ye D, Behlich AS, Mordecai S, Preffer FI, Amzallag A, Ramaswamy S, Hochedlinger K, Orkin SH, Hock H. Distinct, strict requirements for Gfi-1b in adult bone marrow red cell and platelet generation. J Exp Med. 2014 May 05; 211(5):909-27. PMID: 24711581.
    Citations: 19     Fields:    Translation:AnimalsCells
  10. Hughes KR, Gândara RM, Javkar T, Sablitzky F, Hock H, Potten CS, Mahida YR. Heterogeneity in histone 2B-green fluorescent protein-retaining putative small intestinal stem cells at cell position 4 and their absence in the colon. Am J Physiol Gastrointest Liver Physiol. 2012 Dec 01; 303(11):G1188-201. PMID: 22997199.
    Citations: 9     Fields:    Translation:AnimalsCells
  11. Qin J, Whyte WA, Anderssen E, Apostolou E, Chen HH, Akbarian S, Bronson RT, Hochedlinger K, Ramaswamy S, Young RA, Hock H. The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development. Cell Stem Cell. 2012 Sep 07; 11(3):319-32. PMID: 22770845.
    Citations: 33     Fields:    Translation:AnimalsCells
  12. Hock H. A complex Polycomb issue: the two faces of EZH2 in cancer. Genes Dev. 2012 Apr 15; 26(8):751-5. PMID: 22508723.
    Citations: 46     Fields:    Translation:HumansAnimals
  13. Mou F, Praskova M, Xia F, Van Buren D, Hock H, Avruch J, Zhou D. The Mst1 and Mst2 kinases control activation of rho family GTPases and thymic egress of mature thymocytes. J Exp Med. 2012 Apr 09; 209(4):741-59. PMID: 22412158.
    Citations: 47     Fields:    Translation:AnimalsCells
  14. Qin J, Van Buren D, Huang HS, Zhong L, Mostoslavsky R, Akbarian S, Hock H. Chromatin protein L3MBTL1 is dispensable for development and tumor suppression in mice. J Biol Chem. 2010 Sep 03; 285(36):27767-75. PMID: 20592034.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  15. Hock H. Some hematopoietic stem cells are more equal than others. J Exp Med. 2010 Jun 07; 207(6):1127-30. PMID: 20513745.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  16. Monach PA, Nigrovic PA, Chen M, Hock H, Lee DM, Benoist C, Mathis D. Neutrophils in a mouse model of autoantibody-mediated arthritis: critical producers of Fc receptor gamma, the receptor for C5a, and lymphocyte function-associated antigen 1. Arthritis Rheum. 2010 Mar; 62(3):753-64. PMID: 20191628.
    Citations: 39     Fields:    Translation:AnimalsCells
  17. Eminli S, Foudi A, Stadtfeld M, Maherali N, Ahfeldt T, Mostoslavsky G, Hock H, Hochedlinger K. Differentiation stage determines potential of hematopoietic cells for reprogramming into induced pluripotent stem cells. Nat Genet. 2009 Sep; 41(9):968-76. PMID: 19668214.
    Citations: 156     Fields:    Translation:AnimalsCells
  18. Schindler JW, Van Buren D, Foudi A, Krejci O, Qin J, Orkin SH, Hock H. TEL-AML1 corrupts hematopoietic stem cells to persist in the bone marrow and initiate leukemia. Cell Stem Cell. 2009 Jul 02; 5(1):43-53. PMID: 19570513.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  19. Foudi A, Hochedlinger K, Van Buren D, Schindler JW, Jaenisch R, Carey V, Hock H. Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells. Nat Biotechnol. 2009 Jan; 27(1):84-90. PMID: 19060879.
    Citations: 178     Fields:    Translation:HumansAnimalsCells
  20. Li Z, Tognon CE, Godinho FJ, Yasaitis L, Hock H, Herschkowitz JI, Lannon CL, Cho E, Kim SJ, Bronson RT, Perou CM, Sorensen PH, Orkin SH. ETV6-NTRK3 fusion oncogene initiates breast cancer from committed mammary progenitors via activation of AP1 complex. Cancer Cell. 2007 Dec; 12(6):542-58. PMID: 18068631.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  21. Hock H, Orkin SH. Zinc-finger transcription factor Gfi-1: versatile regulator of lymphocytes, neutrophils and hematopoietic stem cells. Curr Opin Hematol. 2006 Jan; 13(1):1-6. PMID: 16319680.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  22. Hock H, Orkin SH. Stem cells: the road not taken. Nature. 2005 Jun 02; 435(7042):573-5. PMID: 15931202.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  23. Hock H, Hamblen MJ, Rooke HM, Schindler JW, Saleque S, Fujiwara Y, Orkin SH. Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells. Nature. 2004 Oct 21; 431(7011):1002-7. PMID: 15457180.
    Citations: 197     Fields:    Translation:AnimalsCells
  24. Hock H, Meade E, Medeiros S, Schindler JW, Valk PJ, Fujiwara Y, Orkin SH. Tel/Etv6 is an essential and selective regulator of adult hematopoietic stem cell survival. Genes Dev. 2004 Oct 01; 18(19):2336-41. PMID: 15371326.
    Citations: 83     Fields:    Translation:AnimalsCells
  25. Tuveson DA, Shaw AT, Willis NA, Silver DP, Jackson EL, Chang S, Mercer KL, Grochow R, Hock H, Crowley D, Hingorani SR, Zaks T, King C, Jacobetz MA, Wang L, Bronson RT, Orkin SH, DePinho RA, Jacks T. Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects. Cancer Cell. 2004 Apr; 5(4):375-87. PMID: 15093544.
    Citations: 305     Fields:    Translation:AnimalsCells
  26. Mikkola HK, Klintman J, Yang H, Hock H, Schlaeger TM, Fujiwara Y, Orkin SH. Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene. Nature. 2003 Jan 30; 421(6922):547-51. PMID: 12540851.
    Citations: 112     Fields:    Translation:AnimalsCells
  27. Hock H, Hamblen MJ, Rooke HM, Traver D, Bronson RT, Cameron S, Orkin SH. Intrinsic requirement for zinc finger transcription factor Gfi-1 in neutrophil differentiation. Immunity. 2003 Jan; 18(1):109-20. PMID: 12530980.
    Citations: 131     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.