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Hanno Reinhard Hock, PH.D., M.D.

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Mentoring
The role of TEL in B lymphocyte development and TEL-AML1-associated pediatric ALL.
Summer, 06/19/06 - 08/11/06

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01CA122726 (HOCK, HANNO R) Apr 1, 2007 - Jan 31, 2012
    NIH/NCI
    Function of zinc-finger transcription factor Gfi-1 in hematopoietic stem cells
    Role: Principal Investigator
  2. K08CA096701 (HOCK, HANNO R) Jul 17, 2002 - Jun 30, 2007
    NIH/NCI
    Recreating Childhood Leukemia in Mice
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Alsufyani F, Mattoo H, Zhou D, Cariappa A, Van Buren D, Hock H, Avruch J, Pillai S. The Mst1 Kinase Is Required for Follicular B Cell Homing and B-1 B Cell Development. Front Immunol. 2018; 9:2393. PMID: 30386341.
    Citations:    
  2. Hock H, Shimamura A. ETV6 in hematopoiesis and leukemia predisposition. Semin Hematol. 2017 04; 54(2):98-104. PMID: 28637624.
    Citations: 1     Fields:    Translation:Humans
  3. Foudi A, Kramer DJ, Qin J, Ye D, Behlich AS, Mordecai S, Preffer FI, Amzallag A, Ramaswamy S, Hochedlinger K, Orkin SH, Hock H. Distinct, strict requirements for Gfi-1b in adult bone marrow red cell and platelet generation. J Exp Med. 2014 May 05; 211(5):909-27. PMID: 24711581.
    Citations: 19     Fields:    Translation:AnimalsCells
  4. Hughes KR, Gândara RM, Javkar T, Sablitzky F, Hock H, Potten CS, Mahida YR. Heterogeneity in histone 2B-green fluorescent protein-retaining putative small intestinal stem cells at cell position 4 and their absence in the colon. Am J Physiol Gastrointest Liver Physiol. 2012 Dec 01; 303(11):G1188-201. PMID: 22997199.
    Citations: 9     Fields:    Translation:AnimalsCells
  5. Qin J, Whyte WA, Anderssen E, Apostolou E, Chen HH, Akbarian S, Bronson RT, Hochedlinger K, Ramaswamy S, Young RA, Hock H. The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development. Cell Stem Cell. 2012 Sep 07; 11(3):319-32. PMID: 22770845.
    Citations: 33     Fields:    Translation:AnimalsCells
  6. Hock H. A complex Polycomb issue: the two faces of EZH2 in cancer. Genes Dev. 2012 Apr 15; 26(8):751-5. PMID: 22508723.
    Citations: 46     Fields:    Translation:HumansAnimals
  7. Mou F, Praskova M, Xia F, Van Buren D, Hock H, Avruch J, Zhou D. The Mst1 and Mst2 kinases control activation of rho family GTPases and thymic egress of mature thymocytes. J Exp Med. 2012 Apr 09; 209(4):741-59. PMID: 22412158.
    Citations: 47     Fields:    Translation:AnimalsCells
  8. Qin J, Van Buren D, Huang HS, Zhong L, Mostoslavsky R, Akbarian S, Hock H. Chromatin protein L3MBTL1 is dispensable for development and tumor suppression in mice. J Biol Chem. 2010 Sep 03; 285(36):27767-75. PMID: 20592034.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  9. Hock H. Some hematopoietic stem cells are more equal than others. J Exp Med. 2010 Jun 07; 207(6):1127-30. PMID: 20513745.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  10. Monach PA, Nigrovic PA, Chen M, Hock H, Lee DM, Benoist C, Mathis D. Neutrophils in a mouse model of autoantibody-mediated arthritis: critical producers of Fc receptor gamma, the receptor for C5a, and lymphocyte function-associated antigen 1. Arthritis Rheum. 2010 Mar; 62(3):753-64. PMID: 20191628.
    Citations: 39     Fields:    Translation:AnimalsCells
  11. Eminli S, Foudi A, Stadtfeld M, Maherali N, Ahfeldt T, Mostoslavsky G, Hock H, Hochedlinger K. Differentiation stage determines potential of hematopoietic cells for reprogramming into induced pluripotent stem cells. Nat Genet. 2009 Sep; 41(9):968-76. PMID: 19668214.
    Citations: 156     Fields:    Translation:AnimalsCells
  12. Schindler JW, Van Buren D, Foudi A, Krejci O, Qin J, Orkin SH, Hock H. TEL-AML1 corrupts hematopoietic stem cells to persist in the bone marrow and initiate leukemia. Cell Stem Cell. 2009 Jul 02; 5(1):43-53. PMID: 19570513.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  13. Foudi A, Hochedlinger K, Van Buren D, Schindler JW, Jaenisch R, Carey V, Hock H. Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells. Nat Biotechnol. 2009 Jan; 27(1):84-90. PMID: 19060879.
    Citations: 178     Fields:    Translation:HumansAnimalsCells
  14. Li Z, Tognon CE, Godinho FJ, Yasaitis L, Hock H, Herschkowitz JI, Lannon CL, Cho E, Kim SJ, Bronson RT, Perou CM, Sorensen PH, Orkin SH. ETV6-NTRK3 fusion oncogene initiates breast cancer from committed mammary progenitors via activation of AP1 complex. Cancer Cell. 2007 Dec; 12(6):542-58. PMID: 18068631.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  15. Hock H, Orkin SH. Zinc-finger transcription factor Gfi-1: versatile regulator of lymphocytes, neutrophils and hematopoietic stem cells. Curr Opin Hematol. 2006 Jan; 13(1):1-6. PMID: 16319680.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  16. Hock H, Orkin SH. Stem cells: the road not taken. Nature. 2005 Jun 02; 435(7042):573-5. PMID: 15931202.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  17. Hock H, Hamblen MJ, Rooke HM, Schindler JW, Saleque S, Fujiwara Y, Orkin SH. Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells. Nature. 2004 Oct 21; 431(7011):1002-7. PMID: 15457180.
    Citations: 197     Fields:    Translation:AnimalsCells
  18. Hock H, Meade E, Medeiros S, Schindler JW, Valk PJ, Fujiwara Y, Orkin SH. Tel/Etv6 is an essential and selective regulator of adult hematopoietic stem cell survival. Genes Dev. 2004 Oct 01; 18(19):2336-41. PMID: 15371326.
    Citations: 83     Fields:    Translation:AnimalsCells
  19. Tuveson DA, Shaw AT, Willis NA, Silver DP, Jackson EL, Chang S, Mercer KL, Grochow R, Hock H, Crowley D, Hingorani SR, Zaks T, King C, Jacobetz MA, Wang L, Bronson RT, Orkin SH, DePinho RA, Jacks T. Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects. Cancer Cell. 2004 Apr; 5(4):375-87. PMID: 15093544.
    Citations: 305     Fields:    Translation:AnimalsCells
  20. Mikkola HK, Klintman J, Yang H, Hock H, Schlaeger TM, Fujiwara Y, Orkin SH. Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene. Nature. 2003 Jan 30; 421(6922):547-51. PMID: 12540851.
    Citations: 112     Fields:    Translation:AnimalsCells
  21. Hock H, Hamblen MJ, Rooke HM, Traver D, Bronson RT, Cameron S, Orkin SH. Intrinsic requirement for zinc finger transcription factor Gfi-1 in neutrophil differentiation. Immunity. 2003 Jan; 18(1):109-20. PMID: 12530980.
    Citations: 131     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.