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Mikael J. Pittet, Ph.D.

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2015 - 2020
Samana Cay Research Scholar

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01CA218579 (KLEIN, ALLON MOSHE) Jul 18, 2018 - Jun 30, 2023
    Single Cell Genome-Wide Myeloid Response Profiling in Immunotherapy
    Role: Co-Principal Investigator
  2. U01CA224348 (JAIN, RAKESH K.) Sep 30, 2017 - Aug 31, 2022
    Reprogramming PDAC tumor microenvironment to improve immunotherapy
    Role: Co-Principal Investigator
  3. R01CA206890 (WEISSLEDER, RALPH) Mar 21, 2017 - Feb 28, 2022
    Imaging tumor associated macrophage (TAM) function
    Role: Co-Principal Investigator
  4. R21CA190344 (PITTET, MIKAEL) Dec 1, 2014 - Nov 30, 2016
    Imaging endogenously produced tumor derived micro vesicles
    Role: Principal Investigator
  5. R01AI084880 (PITTET, MIKAEL) Jun 21, 2010 - Jan 31, 2021
    In vivo behavior of monocytes in resting and inflammatory conditions
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Garris CS, Arlauckas SP, Kohler RH, Trefny MP, Garren S, Piot C, Engblom C, Pfirschke C, Siwicki M, Gungabeesoon J, Freeman GJ, Warren SE, Ong S, Browning E, Twitty CG, Pierce RH, Le MH, Algazi AP, Daud AI, Pai SI, Zippelius A, Weissleder R, Pittet MJ. Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-? and IL-12. Immunity. 2022 Sep 13; 55(9):1749. PMID: 36103861.
    Citations:    Fields:    
  2. Bilous M, Tran L, Cianciaruso C, Gabriel A, Michel H, Carmona SJ, Pittet MJ, Gfeller D. Metacells untangle large and complex single-cell transcriptome networks. BMC Bioinformatics. 2022 Aug 13; 23(1):336. PMID: 35963997; PMCID: PMC9375201.
    Citations: 1     Fields:    Translation:HumansCells
  3. Ho WW, Pittet MJ, Fukumura D, Jain RK. The local microenvironment matters in preclinical basic and translational studies of cancer immunology and immunotherapy. Cancer Cell. 2022 07 11; 40(7):701-702. PMID: 35714604.
    Citations:    Fields:    Translation:Humans
  4. Kim J, Oh J, Peterson HM, Carlson JCT, Pittet MJ, Weissleder R. TNIK Inhibition Has Dual Synergistic Effects on Tumor and Associated Immune Cells. Adv Biol (Weinh). 2022 Aug; 6(8):e2200030. PMID: 35675910; PMCID: PMC9398996.
    Citations:    Fields:    
  5. Ko J, Wilkovitsch M, Oh J, Kohler RH, Bolli E, Pittet MJ, Vinegoni C, Sykes DB, Mikula H, Weissleder R, Carlson JCT. Spatiotemporal multiplexed immunofluorescence imaging of living cells and tissues with bioorthogonal cycling of fluorescent probes. Nat Biotechnol. 2022 11; 40(11):1654-1662. PMID: 35654978; PMCID: PMC9669087.
    Citations:    Fields:    
  6. Pittet MJ, Michielin O, Migliorini D. Author Correction: Clinical relevance of tumour-associated macrophages. Nat Rev Clin Oncol. 2022 Jun; 19(6):424. PMID: 35388204.
    Citations:    Fields:    
  7. Quail DF, Amulic B, Aziz M, Barnes BJ, Eruslanov E, Fridlender ZG, Goodridge HS, Granot Z, Hidalgo A, Huttenlocher A, Kaplan MJ, Malanchi I, Merghoub T, Meylan E, Mittal V, Pittet MJ, Rubio-Ponce A, Udalova IA, van den Berg TK, Wagner DD, Wang P, Zychlinsky A, de Visser KE, Egeblad M, Kubes P. Neutrophil phenotypes and functions in cancer: A consensus statement. J Exp Med. 2022 06 06; 219(6). PMID: 35522219; PMCID: PMC9086501.
    Citations:    Fields:    Translation:HumansCells
  8. Pittet MJ, Michielin O, Migliorini D. Clinical relevance of tumour-associated macrophages. Nat Rev Clin Oncol. 2022 06; 19(6):402-421. PMID: 35354979.
    Citations: 2     Fields:    Translation:HumansCells
  9. Siwicki M, Pittet MJ. Versatile neutrophil functions in cancer. Semin Immunol. 2021 10; 57:101538. PMID: 34876331.
    Citations: 5     Fields:    Translation:HumansCells
  10. Pfirschke C, Zilionis R, Engblom C, Messemaker M, Zou AE, Rickelt S, Gort-Freitas NA, Lin Y, Bill R, Siwicki M, Gungabeesoon J, Sprachman MM, Marquard AN, Rodell CB, Cuccarese MF, Quintana J, Ahmed MS, Kohler RH, Savova V, Weissleder R, Klein AM, Pittet MJ. Macrophage-Targeted Therapy Unlocks Antitumoral Cross-talk between IFN?-Secreting Lymphocytes and IL12-Producing Dendritic Cells. Cancer Immunol Res. 2022 01; 10(1):40-55. PMID: 34795032.
    Citations: 1     Fields:    Translation:AnimalsCells
  11. Ho WW, Gomes-Santos IL, Aoki S, Datta M, Kawaguchi K, Talele NP, Roberge S, Ren J, Liu H, Chen IX, Andersson P, Chatterjee S, Kumar AS, Amoozgar Z, Zhang Q, Huang P, Ng MR, Chauhan VP, Xu L, Duda DG, Clark JW, Pittet MJ, Fukumura D, Jain RK. Dendritic cell paucity in mismatch repair-proficient colorectal cancer liver metastases limits immune checkpoint blockade efficacy. Proc Natl Acad Sci U S A. 2021 11 09; 118(45). PMID: 34725151.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  12. Herrera FG, Ronet C, Ochoa de Olza M, Barras D, Crespo I, Andreatta M, Corria-Osorio J, Spill A, Benedetti F, Genolet R, Orcurto A, Imbimbo M, Ghisoni E, Navarro Rodrigo B, Berthold DR, Sarivalasis A, Zaman K, Duran R, Dromain C, Prior J, Schaefer N, Bourhis J, Dimopoulou G, Tsourti Z, Messemaker M, Smith T, Warren SE, Foukas P, Rusakiewicz S, Pittet MJ, Zimmermann S, Sempoux C, Dafni U, Harari A, Kandalaft LE, Carmona SJ, Dangaj Laniti D, Irving M, Coukos G. Low-Dose Radiotherapy Reverses Tumor Immune Desertification and Resistance to Immunotherapy. Cancer Discov. 2022 01; 12(1):108-133. PMID: 34479871; PMCID: PMC9401506.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  13. Di Pilato M, Kfuri-Rubens R, Pruessmann JN, Ozga AJ, Messemaker M, Cadilha BL, Sivakumar R, Cianciaruso C, Warner RD, Marangoni F, Carrizosa E, Lesch S, Billingsley J, Perez-Ramos D, Zavala F, Rheinbay E, Luster AD, Gerner MY, Kobold S, Pittet MJ, Mempel TR. CXCR6 positions cytotoxic T cells to receive critical survival signals in the tumor microenvironment. Cell. 2021 08 19; 184(17):4512-4530.e22. PMID: 34343496; PMCID: PMC8719451.
    Citations: 21     Fields:    Translation:AnimalsCells
  14. Mattox AK, Roelands J, Saal TM, Cheng Y, Rinchai D, Hendrickx W, Young GD, Diefenbach TJ, Berger AE, Westra WH, Bishop JA, Faquin WC, Marincola FM, Pittet MJ, Bedognetti D, Pai SI. Myeloid Cells Are Enriched in Tonsillar Crypts, Providing Insight into the Viral Tropism of Human Papillomavirus. Am J Pathol. 2021 10; 191(10):1774-1786. PMID: 34303699; PMCID: PMC8491092.
    Citations: 3     Fields:    Translation:HumansCells
  15. Bill R, Deschler DG, Pittet MJ, Pai SI, Sadow PM, Park JC. Diagnostic challenges and successful organ-preserving therapy in a case of secretory carcinoma of minor salivary glands. Cancer Rep (Hoboken). 2022 03; 5(3):e1491. PMID: 34231337; PMCID: PMC8955062.
    Citations: 2     Fields:    Translation:Humans
  16. Oh J, Carlson JCT, Landeros C, Lee H, Ferguson S, Faquin WC, Clark JR, Pittet MJ, Pai SI, Weissleder R. Rapid Serial Immunoprofiling of the Tumor Immune Microenvironment by Fine Needle Sampling. Clin Cancer Res. 2021 09 01; 27(17):4781-4793. PMID: 34233961; PMCID: PMC8416923.
    Citations: 5     Fields:    Translation:HumansAnimals
  17. Siwicki M, Gort-Freitas NA, Messemaker M, Bill R, Gungabeesoon J, Engblom C, Zilionis R, Garris C, Gerhard GM, Kohl A, Lin Y, Zou AE, Cianciaruso C, Bolli E, Pfirschke C, Lin YJ, Piot C, Mindur JE, Talele N, Kohler RH, Iwamoto Y, Mino-Kenudson M, Pai SI, deVito C, Koessler T, Merkler D, Coukos A, Wicky A, Fraga M, Sempoux C, Jain RK, Dietrich PY, Michielin O, Weissleder R, Klein AM, Pittet MJ. Resident Kupffer cells and neutrophils drive liver toxicity in cancer immunotherapy. Sci Immunol. 2021 07 02; 6(61). PMID: 34215680; PMCID: PMC8845079.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  18. Li MO, Wolf N, Raulet DH, Akkari L, Pittet MJ, Rodriguez PC, Kaplan RN, Munitz A, Zhang Z, Cheng S, Bhardwaj N. Innate immune cells in the tumor microenvironment. Cancer Cell. 2021 06 14; 39(6):725-729. PMID: 34129817.
    Citations: 3     Fields:    Translation:HumansCells
  19. Gerhard GM, Bill R, Messemaker M, Klein AM, Pittet MJ. Tumor-infiltrating dendritic cell states are conserved across solid human cancers. J Exp Med. 2021 01 04; 218(1). PMID: 33601412.
    Citations: 13     Fields:    Translation:HumansCells
  20. Pfirschke C, Engblom C, Gungabeesoon J, Lin Y, Rickelt S, Zilionis R, Messemaker M, Siwicki M, Gerhard GM, Kohl A, Meylan E, Weissleder R, Klein AM, Pittet MJ. Tumor-Promoting Ly-6G+ SiglecFhigh Cells Are Mature and Long-Lived Neutrophils. Cell Rep. 2020 09 22; 32(12):108164. PMID: 32966785.
    Citations: 18     Fields:    Translation:AnimalsCells
  21. Pai SI, Faquin WC, Sadow PM, Pittet MJ, Weissleder R. New technology on the horizon: Fast analytical screening technique FNA (FAST-FNA) enables rapid, multiplex biomarker analysis in head and neck cancers. Cancer Cytopathol. 2020 11; 128(11):782-791. PMID: 32841527.
    Citations: 5     Fields:    Translation:Humans
  22. Koch PD, Pittet MJ, Weissleder R. The chemical biology of IL-12 production via the non-canonical NFkB pathway. RSC Chem Biol. 2020 Oct 01; 1(4):166-176. PMID: 34458756; PMCID: PMC8341911.
  23. Weissleder R, Lee H, Ko J, Pittet MJ. COVID-19 diagnostics in context. Sci Transl Med. 2020 06 03; 12(546). PMID: 32493791.
    Citations: 106     Fields:    Translation:HumansCellsPHPublic Health
  24. Boivin G, Faget J, Ancey PB, Gkasti A, Mussard J, Engblom C, Pfirschke C, Contat C, Pascual J, Vazquez J, Bendriss-Vermare N, Caux C, Vozenin MC, Pittet MJ, Gunzer M, Meylan E. Durable and controlled depletion of neutrophils in mice. Nat Commun. 2020 06 02; 11(1):2762. PMID: 32488020.
    Citations: 49     Fields:    Translation:AnimalsCells
  25. Algazi AP, Twitty CG, Tsai KK, Le M, Pierce R, Browning E, Hermiz R, Canton DA, Bannavong D, Oglesby A, Francisco M, Fong L, Pittet MJ, Arlauckas SP, Garris C, Levine LP, Bifulco C, Ballesteros-Merino C, Bhatia S, Gargosky S, Andtbacka RHI, Fox BA, Rosenblum MD, Daud AI. Phase II Trial of IL-12 Plasmid Transfection and PD-1 Blockade in Immunologically Quiescent Melanoma. Clin Cancer Res. 2020 06 15; 26(12):2827-2837. PMID: 32376655; PMCID: PMC9354653.
    Citations: 23     Fields:    Translation:HumansCTClinical Trials
  26. Weissleder R, Pittet MJ. Publisher Correction: The expanding landscape of inflammatory cells affecting cancer therapy. Nat Biomed Eng. 2020 05; 4(5):573. PMID: 32249827.
    Citations:    Fields:    
  27. Weissleder R, Pittet MJ. The expanding landscape of inflammatory cells affecting cancer therapy. Nat Biomed Eng. 2020 05; 4(5):489-498. PMID: 32203281.
    Citations: 11     Fields:    Translation:HumansCells
  28. Ko J, Wang Y, Carlson JCT, Marquard A, Gungabeesoon J, Charest A, Weitz D, Pittet MJ, Weissleder R. Single Extracellular Vesicle Protein Analysis Using Immuno-Droplet Digital Polymerase Chain Reaction Amplification. Adv Biosyst. 2020 12; 4(12):e1900307. PMID: 33274611.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  29. Figueiredo JL, Santa-Cruz F, Lima-Filho JL, Hilgendorf I, Aikawa M, Pittet MJ, Nahrendorf M, Weissleder R, Swirski FK, Robbins CS. A durable murine model of spleen transplantation with arterial and venous anastomoses. Sci Rep. 2020 03 04; 10(1):3979. PMID: 32132617.
    Citations: 1     Fields:    Translation:Animals
  30. Koch PD, Rodell CB, Kohler RH, Pittet MJ, Weissleder R. Myeloid Cell-Targeted Nanocarriers Efficiently Inhibit Cellular Inhibitor of Apoptosis for Cancer Immunotherapy. Cell Chem Biol. 2020 01 16; 27(1):94-104.e5. PMID: 31902676.
    Citations: 6     Fields:    Translation:AnimalsCells
  31. Rodell CB, Ahmed MS, Garris CS, Pittet MJ, Weissleder R. Development of Adamantane-Conjugated TLR7/8 Agonists for Supramolecular Delivery and Cancer Immunotherapy. Theranostics. 2019; 9(26):8426-8436. PMID: 31879528.
    Citations: 22     Fields:    Translation:AnimalsCells
  32. Hoyer FF, Naxerova K, Schloss MJ, Hulsmans M, Nair AV, Dutta P, Calcagno DM, Herisson F, Anzai A, Sun Y, Wojtkiewicz G, Rohde D, Frodermann V, Vandoorne K, Courties G, Iwamoto Y, Garris CS, Williams DL, Breton S, Brown D, Whalen M, Libby P, Pittet MJ, King KR, Weissleder R, Swirski FK, Nahrendorf M. Tissue-Specific Macrophage Responses to Remote Injury Impact the Outcome of Subsequent Local Immune Challenge. Immunity. 2019 11 19; 51(5):899-914.e7. PMID: 31732166.
    Citations: 37     Fields:    Translation:AnimalsCells
  33. Liao HW, Garris C, Pfirschke C, Rickelt S, Arlauckas S, Siwicki M, Kohler RH, Weissleder R, Sundvold-Gjerstad V, Sveinbjørnsson B, Rekdal Ø, Pittet MJ. LTX-315 sequentially promotes lymphocyte-independent and lymphocyte-dependent antitumor effects. Cell Stress. 2019 Oct 14; 3(11):348-360. PMID: 31799501; PMCID: PMC6859426.
    Citations: 3     
  34. Courties G, Frodermann V, Honold L, Zheng Y, Herisson F, Schloss MJ, Sun Y, Presumey J, Severe N, Engblom C, Hulsmans M, Cremer S, Rohde D, Pittet MJ, Scadden DT, Swirski FK, Kim DE, Moskowitz MA, Nahrendorf M. Glucocorticoids Regulate Bone Marrow B Lymphopoiesis After Stroke. Circ Res. 2019 04 26; 124(9):1372-1385. PMID: 30782088; PMCID: PMC6483874.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  35. Liu P, Zhao L, Pol J, Levesque S, Petrazzuolo A, Pfirschke C, Engblom C, Rickelt S, Yamazaki T, Iribarren K, Senovilla L, Bezu L, Vacchelli E, Sica V, Melis A, Martin T, Xia L, Yang H, Li Q, Chen J, Durand S, Aprahamian F, Lefevre D, Broutin S, Paci A, Bongers A, Minard-Colin V, Tartour E, Zitvogel L, Apetoh L, Ma Y, Pittet MJ, Kepp O, Kroemer G. Author Correction: Crizotinib-induced immunogenic cell death in non-small cell lung cancer. Nat Commun. 2019 Apr 17; 10(1):1883. PMID: 30996258.
    Citations: 2     Fields:    
  36. Zilionis R, Engblom C, Pfirschke C, Savova V, Zemmour D, Saatcioglu HD, Krishnan I, Maroni G, Meyerovitz CV, Kerwin CM, Choi S, Richards WG, De Rienzo A, Tenen DG, Bueno R, Levantini E, Pittet MJ, Klein AM. Single-Cell Transcriptomics of Human and Mouse Lung Cancers Reveals Conserved Myeloid Populations across Individuals and Species. Immunity. 2019 05 21; 50(5):1317-1334.e10. PMID: 30979687.
    Citations: 314     Fields:    Translation:HumansAnimalsCells
  37. Liu P, Zhao L, Pol J, Levesque S, Petrazzuolo A, Pfirschke C, Engblom C, Rickelt S, Yamazaki T, Iribarren K, Senovilla L, Bezu L, Vacchelli E, Sica V, Melis A, Martin T, Xia L, Yang H, Li Q, Chen J, Durand S, Aprahamian F, Lefevre D, Broutin S, Paci A, Bongers A, Minard-Colin V, Tartour E, Zitvogel L, Apetoh L, Ma Y, Pittet MJ, Kepp O, Kroemer G. Crizotinib-induced immunogenic cell death in non-small cell lung cancer. Nat Commun. 2019 04 02; 10(1):1486. PMID: 30940805.
    Citations: 73     Fields:    Translation:HumansAnimalsCells
  38. Stokes KL, Cortez-Retamozo V, Acosta J, Lauderback B, Robles-Oteiza C, Cicchini M, Pittet MJ, Feldser DM. Natural killer cells limit the clearance of senescent lung adenocarcinoma cells. Oncogenesis. 2019 Apr 01; 8(4):24. PMID: 30936429.
    Citations: 6     
  39. Jijon HB, Suarez-Lopez L, Diaz OE, Das S, De Calisto J, Parada-Kusz M, Yaffe MB, Pittet MJ, Mora JR, Belkaid Y, Xavier RJ, Villablanca EJ. Correction: Intestinal epithelial cell-specific RARa depletion results in aberrant epithelial cell homeostasis and underdeveloped immune system. Mucosal Immunol. 2019 03; 12(2):580. PMID: 30514887.
    Citations: 1     Fields:    
  40. Garris CS, Arlauckas SP, Kohler RH, Trefny MP, Garren S, Piot C, Engblom C, Pfirschke C, Siwicki M, Gungabeesoon J, Freeman GJ, Warren SE, Ong S, Browning E, Twitty CG, Pierce RH, Le MH, Algazi AP, Daud AI, Pai SI, Zippelius A, Weissleder R, Pittet MJ. Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-? and IL-12. Immunity. 2018 12 18; 49(6):1148-1161.e7. PMID: 30552023; PMCID: PMC6301092.
    Citations: 264     Fields:    Translation:HumansAnimalsCells
  41. Kim HY, Li R, Ng TSC, Courties G, Rodell CB, Prytyskach M, Kohler RH, Pittet MJ, Nahrendorf M, Weissleder R, Miller MA. Quantitative Imaging of Tumor-Associated Macrophages and Their Response to Therapy Using 64Cu-Labeled Macrin. ACS Nano. 2018 12 26; 12(12):12015-12029. PMID: 30508377.
    Citations: 42     Fields:    Translation:AnimalsCells
  42. Arlauckas SP, Garren SB, Garris CS, Kohler RH, Oh J, Pittet MJ, Weissleder R. Arg1 expression defines immunosuppressive subsets of tumor-associated macrophages. Theranostics. 2018; 8(21):5842-5854. PMID: 30613266; PMCID: PMC6299430.
    Citations: 68     Fields:    Translation:AnimalsCells
  43. Oh J, Magnuson A, Benoist C, Pittet MJ, Weissleder R. Age-related tumor growth in mice is related to integrin a 4 in CD8+ T cells. JCI Insight. 2018 11 02; 3(21). PMID: 30385729.
    Citations: 11     Fields:    Translation:AnimalsCells
  44. Pittet MJ, Garris CS, Arlauckas SP, Weissleder R. Recording the wild lives of immune cells. Sci Immunol. 2018 09 07; 3(27). PMID: 30194240; PMCID: PMC6771424.
    Citations: 29     Fields:    Translation:Animals
  45. Rodell CB, Arlauckas SP, Cuccarese MF, Garris CS, Li R, Ahmed MS, Kohler RH, Pittet MJ, Weissleder R. TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy. Nat Biomed Eng. 2018 08; 2(8):578-588. PMID: 31015631; PMCID: PMC6192054.
    Citations: 216     Fields:    Translation:HumansAnimalsCells
  46. Rodell CB, Arlauckas SP, Cuccarese MF, Garris CS, Li R, Ahmed MS, Kohler RH, Pittet MJ, Weissleder R. TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy. Nat Biomed Eng. 2018; 2:578-588. PMID: 30345161.
    Citations: 30     Fields:    
  47. Binnewies M, Roberts EW, Kersten K, Chan V, Fearon DF, Merad M, Coussens LM, Gabrilovich DI, Ostrand-Rosenberg S, Hedrick CC, Vonderheide RH, Pittet MJ, Jain RK, Zou W, Howcroft TK, Woodhouse EC, Weinberg RA, Krummel MF. Understanding the tumor immune microenvironment (TIME) for effective therapy. Nat Med. 2018 05; 24(5):541-550. PMID: 29686425.
    Citations: 1229     Fields:    Translation:Humans
  48. Miller MA, Kim E, Cuccarese MF, Plotkin AL, Prytyskach M, Kohler RH, Pittet MJ, Weissleder R. Near infrared imaging of Mer tyrosine kinase (MERTK) using MERi-SiR reveals tumor associated macrophage uptake in metastatic disease. Chem Commun (Camb). 2017 Dec 19; 54(1):42-45. PMID: 29185561; PMCID: PMC5736449.
    Citations: 8     Fields:    Translation:AnimalsCells
  49. Engblom C, Pfirschke C, Zilionis R, Da Silva Martins J, Bos SA, Courties G, Rickelt S, Severe N, Baryawno N, Faget J, Savova V, Zemmour D, Kline J, Siwicki M, Garris C, Pucci F, Liao HW, Lin YJ, Newton A, Yaghi OK, Iwamoto Y, Tricot B, Wojtkiewicz GR, Nahrendorf M, Cortez-Retamozo V, Meylan E, Hynes RO, Demay M, Klein A, Bredella MA, Scadden DT, Weissleder R, Pittet MJ. Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhigh neutrophils. Science. 2017 12 01; 358(6367). PMID: 29191879; PMCID: PMC6343476.
    Citations: 117     Fields:    Translation:HumansAnimalsCells
  50. Jijon HB, Suarez-Lopez L, Diaz OE, Das S, De Calisto J, Parada-kusz M, Yaffe MB, Pittet MJ, Mora JR, Belkaid Y, Xavier RJ, Villablanca EJ. Intestinal epithelial cell-specific RARa depletion results in aberrant epithelial cell homeostasis and underdeveloped immune system. Mucosal Immunol. 2018 05; 11(3):703-715. PMID: 29139475; PMCID: PMC5953762.
    Citations: 17     Fields:    Translation:AnimalsCells
  51. Miller MA, Chandra R, Cuccarese MF, Pfirschke C, Engblom C, Stapleton S, Adhikary U, Kohler RH, Mohan JF, Pittet MJ, Weissleder R. Radiation therapy primes tumors for nanotherapeutic delivery via macrophage-mediated vascular bursts. Sci Transl Med. 2017 05 31; 9(392). PMID: 28566423; PMCID: PMC6681815.
    Citations: 76     Fields:    Translation:HumansAnimalsCells
  52. Arlauckas SP, Garris CS, Kohler RH, Kitaoka M, Cuccarese MF, Yang KS, Miller MA, Carlson JC, Freeman GJ, Anthony RM, Weissleder R, Pittet MJ. In vivo imaging reveals a tumor-associated macrophage-mediated resistance pathway in anti-PD-1 therapy. Sci Transl Med. 2017 05 10; 9(389). PMID: 28490665; PMCID: PMC5734617.
    Citations: 230     Fields:    Translation:HumansAnimalsCells
  53. Pfirschke C, Siwicki M, Liao HW, Pittet MJ. Tumor Microenvironment: No Effector T Cells without Dendritic Cells. Cancer Cell. 2017 05 08; 31(5):614-615. PMID: 28486102.
    Citations: 19     Fields:    Translation:HumansCells
  54. Cuccarese MF, Dubach JM, Pfirschke C, Engblom C, Garris C, Miller MA, Pittet MJ, Weissleder R. Heterogeneity of macrophage infiltration and therapeutic response in lung carcinoma revealed by 3D organ imaging. Nat Commun. 2017 02 08; 8:14293. PMID: 28176769.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  55. Pucci F, Rickelt S, Newton AP, Garris C, Nunes E, Evavold C, Pfirschke C, Engblom C, Mino-Kenudson M, Hynes RO, Weissleder R, Pittet MJ. PF4 Promotes Platelet Production and Lung Cancer Growth. Cell Rep. 2016 11 08; 17(7):1764-1772. PMID: 27829148; PMCID: PMC5108525.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  56. Siwicki M, Engblom C, Pittet MJ. Gal3 Links Inflammation and Insulin Resistance. Cell Metab. 2016 11 08; 24(5):655-656. PMID: 27829136.
    Citations: 7     Fields:    Translation:Humans
  57. Engblom C, Pfirschke C, Pittet MJ. The role of myeloid cells in cancer therapies. Nat Rev Cancer. 2016 07; 16(7):447-62. PMID: 27339708.
    Citations: 266     Fields:    Translation:HumansCells
  58. Spiegel A, Brooks MW, Houshyar S, Reinhardt F, Ardolino M, Fessler E, Chen MB, Krall JA, DeCock J, Zervantonakis IK, Iannello A, Iwamoto Y, Cortez-Retamozo V, Kamm RD, Pittet MJ, Raulet DH, Weinberg RA. Neutrophils Suppress Intraluminal NK Cell-Mediated Tumor Cell Clearance and Enhance Extravasation of Disseminated Carcinoma Cells. Cancer Discov. 2016 06; 6(6):630-49. PMID: 27072748; PMCID: PMC4918202.
    Citations: 191     Fields:    Translation:HumansAnimalsCells
  59. Pucci F, Garris C, Lai CP, Newton A, Pfirschke C, Engblom C, Alvarez D, Sprachman M, Evavold C, Magnuson A, von Andrian UH, Glatz K, Breakefield XO, Mempel TR, Weissleder R, Pittet MJ. SCS macrophages suppress melanoma by restricting tumor-derived vesicle-B cell interactions. Science. 2016 Apr 08; 352(6282):242-6. PMID: 26989197.
    Citations: 122     Fields:    Translation:HumansAnimalsCells
  60. Pfirschke C, Engblom C, Rickelt S, Cortez-Retamozo V, Garris C, Pucci F, Yamazaki T, Poirier-Colame V, Newton A, Redouane Y, Lin YJ, Wojtkiewicz G, Iwamoto Y, Mino-Kenudson M, Huynh TG, Hynes RO, Freeman GJ, Kroemer G, Zitvogel L, Weissleder R, Pittet MJ. Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy. Immunity. 2016 Feb 16; 44(2):343-54. PMID: 26872698; PMCID: PMC4758865.
    Citations: 342     Fields:    Translation:HumansAnimalsCells
  61. Ramasamy S, Saez B, Mukhopadhyay S, Ding D, Ahmed AM, Chen X, Pucci F, Yamin R, Wang J, Pittet MJ, Kelleher CM, Scadden DT, Sweetser DA. Tle1 tumor suppressor negatively regulates inflammation in vivo and modulates NF-?B inflammatory pathway. Proc Natl Acad Sci U S A. 2016 Feb 16; 113(7):1871-6. PMID: 26831087; PMCID: PMC4763742.
    Citations: 33     Fields:    Translation:Animals
  62. Miller MA, Gadde S, Pfirschke C, Engblom C, Sprachman MM, Kohler RH, Yang KS, Laughney AM, Wojtkiewicz G, Kamaly N, Bhonagiri S, Pittet MJ, Farokhzad OC, Weissleder R. Predicting therapeutic nanomedicine efficacy using a companion magnetic resonance imaging nanoparticle. Sci Transl Med. 2015 Nov 18; 7(314):314ra183. PMID: 26582898.
    Citations: 113     Fields:    Translation:HumansAnimalsCells
  63. Miller MA, Zheng YR, Gadde S, Pfirschke C, Zope H, Engblom C, Kohler RH, Iwamoto Y, Yang KS, Askevold B, Kolishetti N, Pittet M, Lippard SJ, Farokhzad OC, Weissleder R. Tumour-associated macrophages act as a slow-release reservoir of nano-therapeutic Pt(IV) pro-drug. Nat Commun. 2015 Oct 27; 6:8692. PMID: 26503691; PMCID: PMC4711745.
    Citations: 135     Fields:    Translation:HumansAnimalsCells
  64. Garris CS, Pittet MJ. ER Stress in Dendritic Cells Promotes Cancer. Cell. 2015 Jun 18; 161(7):1492-3. PMID: 26091029.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  65. Azroyan A, Cortez-Retamozo V, Bouley R, Liberman R, Ruan YC, Kiselev E, Jacobson KA, Pittet MJ, Brown D, Breton S. Renal intercalated cells sense and mediate inflammation via the P2Y14 receptor. PLoS One. 2015; 10(3):e0121419. PMID: 25799465.
    Citations: 33     Fields:    Translation:AnimalsCells
  66. Pfirschke C, Garris C, Pittet MJ. Common TLR5 mutations control cancer progression. Cancer Cell. 2015 Jan 12; 27(1):1-3. PMID: 25584886.
    Citations: 6     Fields:    Translation:HumansAnimals
  67. Sistigu A, Yamazaki T, Vacchelli E, Chaba K, Enot DP, Adam J, Vitale I, Goubar A, Baracco EE, Remédios C, Fend L, Hannani D, Aymeric L, Ma Y, Niso-Santano M, Kepp O, Schultze JL, Tüting T, Belardelli F, Bracci L, La Sorsa V, Ziccheddu G, Sestili P, Urbani F, Delorenzi M, Lacroix-Triki M, Quidville V, Conforti R, Spano JP, Pusztai L, Poirier-Colame V, Delaloge S, Penault-Llorca F, Ladoire S, Arnould L, Cyrta J, Dessoliers MC, Eggermont A, Bianchi ME, Pittet M, Engblom C, Pfirschke C, Préville X, Uzè G, Schreiber RD, Chow MT, Smyth MJ, Proietti E, André F, Kroemer G, Zitvogel L. Cancer cell-autonomous contribution of type I interferon signaling to the efficacy of chemotherapy. Nat Med. 2014 Nov; 20(11):1301-9. PMID: 25344738.
    Citations: 394     Fields:    Translation:HumansAnimalsCells
  68. Smith TB, Cortez-Retamozo V, Grigoryeva LS, Hill E, Pittet MJ, Da Silva N. Mononuclear phagocytes rapidly clear apoptotic epithelial cells in the proximal epididymis. Andrology. 2014 Sep; 2(5):755-62. PMID: 25082073.
    Citations: 20     Fields:    Translation:AnimalsCells
  69. Aranda F, Bloy N, Pesquet J, Petit B, Chaba K, Sauvat A, Kepp O, Khadra N, Enot D, Pfirschke C, Pittet M, Zitvogel L, Kroemer G, Senovilla L. Immune-dependent antineoplastic effects of cisplatin plus pyridoxine in non-small-cell lung cancer. Oncogene. 2015 Jun 04; 34(23):3053-62. PMID: 25065595.
    Citations: 34     Fields:    Translation:AnimalsCells
  70. Viaud S, Daillère R, Boneca IG, Lepage P, Langella P, Chamaillard M, Pittet MJ, Ghiringhelli F, Trinchieri G, Goldszmid R, Zitvogel L. Gut microbiome and anticancer immune response: really hot Sh*t! Cell Death Differ. 2015 Feb; 22(2):199-214. PMID: 24832470.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  71. Shum WW, Smith TB, Cortez-Retamozo V, Grigoryeva LS, Roy JW, Hill E, Pittet MJ, Breton S, Da Silva N. Epithelial basal cells are distinct from dendritic cells and macrophages in the mouse epididymis. Biol Reprod. 2014 May; 90(5):90. PMID: 24648397.
    Citations: 32     Fields:    Translation:AnimalsCells
  72. Pittet MJ, Nahrendorf M, Swirski FK. The journey from stem cell to macrophage. Ann N Y Acad Sci. 2014 Jun; 1319:1-18. PMID: 24673186.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  73. Weissleder R, Nahrendorf M, Pittet MJ. Imaging macrophages with nanoparticles. Nat Mater. 2014 Feb; 13(2):125-38. PMID: 24452356.
    Citations: 247     Fields:    Translation:HumansCells
  74. Viaud S, Saccheri F, Mignot G, Yamazaki T, Daillère R, Hannani D, Enot DP, Pfirschke C, Engblom C, Pittet MJ, Schlitzer A, Ginhoux F, Apetoh L, Chachaty E, Woerther PL, Eberl G, Bérard M, Ecobichon C, Clermont D, Bizet C, Gaboriau-Routhiau V, Cerf-Bensussan N, Opolon P, Yessaad N, Vivier E, Ryffel B, Elson CO, Doré J, Kroemer G, Lepage P, Boneca IG, Ghiringhelli F, Zitvogel L. The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide. Science. 2013 Nov 22; 342(6161):971-6. PMID: 24264990.
    Citations: 653     Fields:    Translation:AnimalsCells
  75. Bronte V, Pittet MJ. The spleen in local and systemic regulation of immunity. Immunity. 2013 Nov 14; 39(5):806-18. PMID: 24238338.
    Citations: 254     Fields:    Translation:HumansAnimalsCells
  76. Schietinger A, Arina A, Liu RB, Wells S, Huang J, Engels B, Bindokas V, Bartkowiak T, Lee D, Herrmann A, Piston DW, Pittet MJ, Lin PC, Zal T, Schreiber H. Longitudinal confocal microscopy imaging of solid tumor destruction following adoptive T cell transfer. Oncoimmunology. 2013 Nov 01; 2(11):e26677. PMID: 24482750.
    Citations: 25     Fields:    
  77. Garris C, Pittet MJ. Therapeutically reeducating macrophages to treat GBM. Nat Med. 2013 Oct; 19(10):1207-8. PMID: 24100977.
    Citations: 14     Fields:    Translation:AnimalsCells
  78. Cortez-Retamozo V, Engblom C, Pittet MJ. Remote control of macrophage production by cancer. Oncoimmunology. 2013 May 01; 2(5):e24183. PMID: 23762799.
    Citations: 3     Fields:    
  79. Squadrito ML, Etzrodt M, De Palma M, Pittet MJ. MicroRNA-mediated control of macrophages and its implications for cancer. Trends Immunol. 2013 Jul; 34(7):350-9. PMID: 23498847.
    Citations: 85     Fields:    Translation:HumansAnimalsCells
  80. Pucci F, Pittet MJ. Molecular pathways: tumor-derived microvesicles and their interactions with immune cells in vivo. Clin Cancer Res. 2013 May 15; 19(10):2598-604. PMID: 23426276.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  81. Cortez-Retamozo V, Etzrodt M, Newton A, Ryan R, Pucci F, Sio SW, Kuswanto W, Rauch PJ, Chudnovskiy A, Iwamoto Y, Kohler R, Marinelli B, Gorbatov R, Wojtkiewicz G, Panizzi P, Mino-Kenudson M, Forghani R, Figueiredo JL, Chen JW, Xavier R, Swirski FK, Nahrendorf M, Weissleder R, Pittet MJ. Angiotensin II drives the production of tumor-promoting macrophages. Immunity. 2013 Feb 21; 38(2):296-308. PMID: 23333075.
    Citations: 84     Fields:    Translation:HumansAnimalsCells
  82. Lau KS, Cortez-Retamozo V, Philips SR, Pittet MJ, Lauffenburger DA, Haigis KM. Multi-scale in vivo systems analysis reveals the influence of immune cells on TNF-a-induced apoptosis in the intestinal epithelium. PLoS Biol. 2012; 10(9):e1001393. PMID: 23055830.
    Citations: 35     Fields:    Translation:AnimalsCells
  83. Dutta P, Courties G, Wei Y, Leuschner F, Gorbatov R, Robbins CS, Iwamoto Y, Thompson B, Carlson AL, Heidt T, Majmudar MD, Lasitschka F, Etzrodt M, Waterman P, Waring MT, Chicoine AT, van der Laan AM, Niessen HW, Piek JJ, Rubin BB, Butany J, Stone JR, Katus HA, Murphy SA, Morrow DA, Sabatine MS, Vinegoni C, Moskowitz MA, Pittet MJ, Libby P, Lin CP, Swirski FK, Weissleder R, Nahrendorf M. Myocardial infarction accelerates atherosclerosis. Nature. 2012 Jul 19; 487(7407):325-9. PMID: 22763456.
    Citations: 414     Fields:    Translation:AnimalsCells
  84. Etzrodt M, Cortez-Retamozo V, Newton A, Zhao J, Ng A, Wildgruber M, Romero P, Wurdinger T, Xavier R, Geissmann F, Meylan E, Nahrendorf M, Swirski FK, Baltimore D, Weissleder R, Pittet MJ. Regulation of monocyte functional heterogeneity by miR-146a and Relb. Cell Rep. 2012 Apr 19; 1(4):317-24. PMID: 22545247.
    Citations: 66     Fields:    Translation:HumansAnimalsCells
  85. Cortez-Retamozo V, Etzrodt M, Pittet MJ. Regulation of macrophage and dendritic cell responses by their lineage precursors. J Innate Immun. 2012; 4(5-6):411-23. PMID: 22433183.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  86. Cortez-Retamozo V, Etzrodt M, Newton A, Rauch PJ, Chudnovskiy A, Berger C, Ryan RJ, Iwamoto Y, Marinelli B, Gorbatov R, Forghani R, Novobrantseva TI, Koteliansky V, Figueiredo JL, Chen JW, Anderson DG, Nahrendorf M, Swirski FK, Weissleder R, Pittet MJ. Origins of tumor-associated macrophages and neutrophils. Proc Natl Acad Sci U S A. 2012 Feb 14; 109(7):2491-6. PMID: 22308361.
    Citations: 266     Fields:    Translation:HumansAnimalsCells
  87. Rauch PJ, Chudnovskiy A, Robbins CS, Weber GF, Etzrodt M, Hilgendorf I, Tiglao E, Figueiredo JL, Iwamoto Y, Theurl I, Gorbatov R, Waring MT, Chicoine AT, Mouded M, Pittet MJ, Nahrendorf M, Weissleder R, Swirski FK. Innate response activator B cells protect against microbial sepsis. Science. 2012 Feb 03; 335(6068):597-601. PMID: 22245738.
    Citations: 186     Fields:    Translation:AnimalsCells
  88. Lee WW, Marinelli B, van der Laan AM, Sena BF, Gorbatov R, Leuschner F, Dutta P, Iwamoto Y, Ueno T, Begieneman MP, Niessen HW, Piek JJ, Vinegoni C, Pittet MJ, Swirski FK, Tawakol A, Di Carli M, Weissleder R, Nahrendorf M. PET/MRI of inflammation in myocardial infarction. J Am Coll Cardiol. 2012 Jan 10; 59(2):153-63. PMID: 22222080; PMCID: PMC3257823.
    Citations: 139     Fields:    Translation:HumansAnimalsCells
  89. Leuschner F, Rauch PJ, Ueno T, Gorbatov R, Marinelli B, Lee WW, Dutta P, Wei Y, Robbins C, Iwamoto Y, Sena B, Chudnovskiy A, Panizzi P, Keliher E, Higgins JM, Libby P, Moskowitz MA, Pittet MJ, Swirski FK, Weissleder R, Nahrendorf M. Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis. J Exp Med. 2012 Jan 16; 209(1):123-37. PMID: 22213805.
    Citations: 231     Fields:    Translation:AnimalsCells
  90. Robbins CS, Chudnovskiy A, Rauch PJ, Figueiredo JL, Iwamoto Y, Gorbatov R, Etzrodt M, Weber GF, Ueno T, van Rooijen N, Mulligan-Kehoe MJ, Libby P, Nahrendorf M, Pittet MJ, Weissleder R, Swirski FK. Extramedullary hematopoiesis generates Ly-6C(high) monocytes that infiltrate atherosclerotic lesions. Circulation. 2012 Jan 17; 125(2):364-74. PMID: 22144566; PMCID: PMC3263762.
    Citations: 204     Fields:    Translation:AnimalsCells
  91. Pittet MJ, Weissleder R. Intravital imaging. Cell. 2011 Nov 23; 147(5):983-91. PMID: 22118457.
    Citations: 219     Fields:    Translation:HumansAnimals
  92. Keliher EJ, Yoo J, Nahrendorf M, Lewis JS, Marinelli B, Newton A, Pittet MJ, Weissleder R. 89Zr-labeled dextran nanoparticles allow in vivo macrophage imaging. Bioconjug Chem. 2011 Dec 21; 22(12):2383-9. PMID: 22035047.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  93. Leuschner F, Dutta P, Gorbatov R, Novobrantseva TI, Donahoe JS, Courties G, Lee KM, Kim JI, Markmann JF, Marinelli B, Panizzi P, Lee WW, Iwamoto Y, Milstein S, Epstein-Barash H, Cantley W, Wong J, Cortez-Retamozo V, Newton A, Love K, Libby P, Pittet MJ, Swirski FK, Koteliansky V, Langer R, Weissleder R, Anderson DG, Nahrendorf M. Therapeutic siRNA silencing in inflammatory monocytes in mice. Nat Biotechnol. 2011 Oct 09; 29(11):1005-10. PMID: 21983520.
    Citations: 336     Fields:    Translation:HumansAnimalsCells
  94. Pittet MJ, Swirski FK. Monocytes link atherosclerosis and cancer. Eur J Immunol. 2011 Sep; 41(9):2519-22. PMID: 21952809.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  95. Panizzi P, Nahrendorf M, Figueiredo JL, Panizzi J, Marinelli B, Iwamoto Y, Keliher E, Maddur AA, Waterman P, Kroh HK, Leuschner F, Aikawa E, Swirski FK, Pittet MJ, Hackeng TM, Fuentes-Prior P, Schneewind O, Bock PE, Weissleder R. In vivo detection of Staphylococcus aureus endocarditis by targeting pathogen-specific prothrombin activation. Nat Med. 2011 Aug 21; 17(9):1142-6. PMID: 21857652.
    Citations: 64     Fields:    Translation:AnimalsCells
  96. Da Silva N, Cortez-Retamozo V, Reinecker HC, Wildgruber M, Hill E, Brown D, Swirski FK, Pittet MJ, Breton S. A dense network of dendritic cells populates the murine epididymis. Reproduction. 2011 May; 141(5):653-63. PMID: 21310816.
    Citations: 44     Fields:    Translation:AnimalsCells
  97. Nahrendorf M, Keliher E, Marinelli B, Leuschner F, Robbins CS, Gerszten RE, Pittet MJ, Swirski FK, Weissleder R. Detection of macrophages in aortic aneurysms by nanoparticle positron emission tomography-computed tomography. Arterioscler Thromb Vasc Biol. 2011 Apr; 31(4):750-7. PMID: 21252070.
    Citations: 72     Fields:    Translation:AnimalsCells
  98. Xia Y, Cortez-Retamozo V, Niederkofler V, Salie R, Chen S, Samad TA, Hong CC, Arber S, Vyas JM, Weissleder R, Pittet MJ, Lin HY. Dragon (repulsive guidance molecule b) inhibits IL-6 expression in macrophages. J Immunol. 2011 Feb 01; 186(3):1369-76. PMID: 21187450; PMCID: PMC3670585.
    Citations: 28     Fields:    Translation:AnimalsCells
  99. Issadore D, Shao H, Chung J, Newton A, Pittet M, Weissleder R, Lee H. Self-assembled magnetic filter for highly efficient immunomagnetic separation. Lab Chip. 2011 Jan 07; 11(1):147-51. PMID: 20949198.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  100. Leuschner F, Panizzi P, Chico-Calero I, Lee WW, Ueno T, Cortez-Retamozo V, Waterman P, Gorbatov R, Marinelli B, Iwamoto Y, Chudnovskiy A, Figueiredo JL, Sosnovik DE, Pittet MJ, Swirski FK, Weissleder R, Nahrendorf M. Angiotensin-converting enzyme inhibition prevents the release of monocytes from their splenic reservoir in mice with myocardial infarction. Circ Res. 2010 Nov 26; 107(11):1364-73. PMID: 20930148.
    Citations: 110     Fields:    Translation:AnimalsCells
  101. Swirski FK, Wildgruber M, Ueno T, Figueiredo JL, Panizzi P, Iwamoto Y, Zhang E, Stone JR, Rodriguez E, Chen JW, Pittet MJ, Weissleder R, Nahrendorf M. Myeloperoxidase-rich Ly-6C+ myeloid cells infiltrate allografts and contribute to an imaging signature of organ rejection in mice. J Clin Invest. 2010 Jul; 120(7):2627-34. PMID: 20577051; PMCID: PMC2898607.
    Citations: 51     Fields:    Translation:AnimalsCells
  102. Nahrendorf M, Pittet MJ, Swirski FK. Monocytes: protagonists of infarct inflammation and repair after myocardial infarction. Circulation. 2010 Jun 08; 121(22):2437-45. PMID: 20530020; PMCID: PMC2892474.
    Citations: 325     Fields:    Translation:HumansAnimalsCells
  103. Panizzi P, Swirski FK, Figueiredo JL, Waterman P, Sosnovik DE, Aikawa E, Libby P, Pittet M, Weissleder R, Nahrendorf M. Impaired infarct healing in atherosclerotic mice with Ly-6C(hi) monocytosis. J Am Coll Cardiol. 2010 Apr 13; 55(15):1629-38. PMID: 20378083; PMCID: PMC2852892.
    Citations: 166     Fields:    Translation:AnimalsCells
  104. Nahrendorf M, Keliher E, Marinelli B, Waterman P, Feruglio PF, Fexon L, Pivovarov M, Swirski FK, Pittet MJ, Vinegoni C, Weissleder R. Hybrid PET-optical imaging using targeted probes. Proc Natl Acad Sci U S A. 2010 Apr 27; 107(17):7910-5. PMID: 20385821.
    Citations: 87     Fields:    Translation:Animals
  105. Vinegoni C, Fumene Feruglio P, Cortez-Retamozo V, Razansky D, Medoff BD, Ntziachristos V, Sbarbati A, Pittet M, Weissleder R. Imaging of molecular probe activity with Born-normalized fluorescence optical projection tomography. Opt Lett. 2010 Apr 01; 35(7):1088-90. PMID: 20364226.
    Citations: 3     Fields:    
  106. Swirski FK, Nahrendorf M, Etzrodt M, Wildgruber M, Cortez-Retamozo V, Panizzi P, Figueiredo JL, Kohler RH, Chudnovskiy A, Waterman P, Aikawa E, Mempel TR, Libby P, Weissleder R, Pittet MJ. Identification of splenic reservoir monocytes and their deployment to inflammatory sites. Science. 2009 Jul 31; 325(5940):612-6. PMID: 19644120.
    Citations: 922     Fields:    Translation:AnimalsCells
  107. Nahrendorf M, Waterman P, Thurber G, Groves K, Rajopadhye M, Panizzi P, Marinelli B, Aikawa E, Pittet MJ, Swirski FK, Weissleder R. Hybrid in vivo FMT-CT imaging of protease activity in atherosclerosis with customized nanosensors. Arterioscler Thromb Vasc Biol. 2009 Oct; 29(10):1444-51. PMID: 19608968.
    Citations: 89     Fields:    Translation:Animals
  108. Wildgruber M, Lee H, Chudnovskiy A, Yoon TJ, Etzrodt M, Pittet MJ, Nahrendorf M, Croce K, Libby P, Weissleder R, Swirski FK. Monocyte subset dynamics in human atherosclerosis can be profiled with magnetic nano-sensors. PLoS One. 2009 May 22; 4(5):e5663. PMID: 19461894.
    Citations: 30     Fields:    Translation:HumansCells
  109. Leimgruber A, Berger C, Cortez-Retamozo V, Etzrodt M, Newton AP, Waterman P, Figueiredo JL, Kohler RH, Elpek N, Mempel TR, Swirski FK, Nahrendorf M, Weissleder R, Pittet MJ. Behavior of endogenous tumor-associated macrophages assessed in vivo using a functionalized nanoparticle. Neoplasia. 2009 May; 11(5):459-68, 2 p following 468. PMID: 19412430.
    Citations: 54     Fields:    Translation:AnimalsCells
  110. Swirski FK, Weissleder R, Pittet MJ. Heterogeneous in vivo behavior of monocyte subsets in atherosclerosis. Arterioscler Thromb Vasc Biol. 2009 Oct; 29(10):1424-32. PMID: 19372462.
    Citations: 64     Fields:    Translation:HumansAnimalsCells
  111. Pittet MJ. Behavior of immune players in the tumor microenvironment. Curr Opin Oncol. 2009 Jan; 21(1):53-9. PMID: 19125019.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  112. Cortez-Retamozo V, Swirski FK, Waterman P, Yuan H, Figueiredo JL, Newton AP, Upadhyay R, Vinegoni C, Kohler R, Blois J, Smith A, Nahrendorf M, Josephson L, Weissleder R, Pittet MJ. Real-time assessment of inflammation and treatment response in a mouse model of allergic airway inflammation. J Clin Invest. 2008 Dec; 118(12):4058-66. PMID: 19033674; PMCID: PMC2579705.
    Citations: 42     Fields:    Translation:AnimalsCells
  113. Libby P, Nahrendorf M, Pittet MJ, Swirski FK. Diversity of denizens of the atherosclerotic plaque: not all monocytes are created equal. Circulation. 2008 Jun 24; 117(25):3168-70. PMID: 18574058.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  114. Shaw SY, Westly EC, Pittet MJ, Subramanian A, Schreiber SL, Weissleder R. Perturbational profiling of nanomaterial biologic activity. Proc Natl Acad Sci U S A. 2008 May 27; 105(21):7387-92. PMID: 18492802.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  115. Weissleder R, Pittet MJ. Imaging in the era of molecular oncology. Nature. 2008 Apr 03; 452(7187):580-9. PMID: 18385732.
    Citations: 646     Fields:    Translation:Humans
  116. Pittet MJ, Mempel TR. Regulation of T-cell migration and effector functions: insights from in vivo imaging studies. Immunol Rev. 2008 Feb; 221:107-29. PMID: 18275478.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  117. Magnusson FC, Liblau RS, von Boehmer H, Pittet MJ, Lee JW, Turley SJ, Khazaie K. Direct presentation of antigen by lymph node stromal cells protects against CD8 T-cell-mediated intestinal autoimmunity. Gastroenterology. 2008 Apr; 134(4):1028-37. PMID: 18395084.
    Citations: 48     Fields:    Translation:AnimalsCells
  118. Nahrendorf M, Swirski FK, Aikawa E, Stangenberg L, Wurdinger T, Figueiredo JL, Libby P, Weissleder R, Pittet MJ. The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions. J Exp Med. 2007 Nov 26; 204(12):3037-47. PMID: 18025128.
    Citations: 959     Fields:    Translation:AnimalsCells
  119. Swirski FK, Berger CR, Figueiredo JL, Mempel TR, von Andrian UH, Pittet MJ, Weissleder R. A near-infrared cell tracker reagent for multiscopic in vivo imaging and quantification of leukocyte immune responses. PLoS One. 2007 Oct 24; 2(10):e1075. PMID: 17957257.
    Citations: 39     Fields:    Translation:AnimalsCells
  120. Pittet MJ, Grimm J, Berger CR, Tamura T, Wojtkiewicz G, Nahrendorf M, Romero P, Swirski FK, Weissleder R. In vivo imaging of T cell delivery to tumors after adoptive transfer therapy. Proc Natl Acad Sci U S A. 2007 Jul 24; 104(30):12457-61. PMID: 17640914; PMCID: PMC1941490.
    Citations: 56     Fields:    Translation:AnimalsCells
  121. Tam JM, Upadhyay R, Pittet MJ, Weissleder R, Mahmood U. Improved in vivo whole-animal detection limits of green fluorescent protein-expressing tumor lines by spectral fluorescence imaging. Mol Imaging. 2007 Jul-Aug; 6(4):269-76. PMID: 17711782.
    Citations: 13     Fields:    Translation:AnimalsCells
  122. Nahrendorf M, Sosnovik DE, Waterman P, Swirski FK, Pande AN, Aikawa E, Figueiredo JL, Pittet MJ, Weissleder R. Dual channel optical tomographic imaging of leukocyte recruitment and protease activity in the healing myocardial infarct. Circ Res. 2007 Apr 27; 100(8):1218-25. PMID: 17379832.
    Citations: 87     Fields:    Translation:AnimalsCells
  123. Swirski FK, Libby P, Aikawa E, Alcaide P, Luscinskas FW, Weissleder R, Pittet MJ. Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata. J Clin Invest. 2007 Jan; 117(1):195-205. PMID: 17200719; PMCID: PMC1716211.
    Citations: 581     Fields:    Translation:AnimalsCells
  124. Mempel TR, Pittet MJ, Khazaie K, Weninger W, Weissleder R, von Boehmer H, von Andrian UH. Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation. Immunity. 2006 Jul; 25(1):129-41. PMID: 16860762.
    Citations: 221     Fields:    Translation:AnimalsCells
  125. Swirski FK, Pittet MJ, Kircher MF, Aikawa E, Jaffer FA, Libby P, Weissleder R. Monocyte accumulation in mouse atherogenesis is progressive and proportional to extent of disease. Proc Natl Acad Sci U S A. 2006 Jul 05; 103(27):10340-10345. PMID: 16801531; PMCID: PMC1502459.
    Citations: 167     Fields:    Translation:AnimalsCells
  126. Tréhin R, Figueiredo JL, Pittet MJ, Weissleder R, Josephson L, Mahmood U. Fluorescent nanoparticle uptake for brain tumor visualization. Neoplasia. 2006 Apr; 8(4):302-11. PMID: 16756722.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  127. Pittet MJ, Swirski FK, Reynolds F, Josephson L, Weissleder R. Labeling of immune cells for in vivo imaging using magnetofluorescent nanoparticles. Nat Protoc. 2006; 1(1):73-9. PMID: 17406214.
    Citations: 50     Fields:    Translation:AnimalsCells
  128. Montes M, Rufer N, Appay V, Reynard S, Pittet MJ, Speiser DE, Guillaume P, Cerottini JC, Romero P, Leyvraz S. Optimum in vitro expansion of human antigen-specific CD8 T cells for adoptive transfer therapy. Clin Exp Immunol. 2005 Nov; 142(2):292-302. PMID: 16232216; PMCID: PMC1809512.
    Citations: 14     Fields:    Translation:HumansCells
  129. Chen ML, Pittet MJ, Gorelik L, Flavell RA, Weissleder R, von Boehmer H, Khazaie K. Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-beta signals in vivo. Proc Natl Acad Sci U S A. 2005 Jan 11; 102(2):419-24. PMID: 15623559; PMCID: PMC544311.
    Citations: 278     Fields:    Translation:AnimalsCells
  130. Rufer N, Zippelius A, Batard P, Pittet MJ, Kurth I, Corthesy P, Cerottini JC, Leyvraz S, Roosnek E, Nabholz M, Romero P. Ex vivo characterization of human CD8+ T subsets with distinct replicative history and partial effector functions. Blood. 2003 Sep 01; 102(5):1779-87. PMID: 12750165.
    Citations: 53     Fields:    Translation:HumansCells
  131. Romero P, Pittet M, Dutoit V, Zippelius A, Liénard D, Lejeune F, Guillaume P, Rimoldi D, Valmori D, Speiser DE, Cerottini JC. Therapeutic cancer vaccines based on molecularly defined human tumor antigens. Vaccine. 2002 Dec 19; 20 Suppl 4:A2-7. PMID: 12477422.
    Citations: 2     Fields:    Translation:HumansCells
  132. Romero P, Valmori D, Pittet MJ, Zippelius A, Rimoldi D, Lévy F, Dutoit V, Ayyoub M, Rubio-Godoy V, Michielin O, Guillaume P, Batard P, Luescher IF, Lejeune F, Liénard D, Rufer N, Dietrich PY, Speiser DE, Cerottini JC. Antigenicity and immunogenicity of Melan-A/MART-1 derived peptides as targets for tumor reactive CTL in human melanoma. Immunol Rev. 2002 Oct; 188:81-96. PMID: 12445283.
    Citations: 48     Fields:    Translation:HumansCells
  133. Speiser DE, Colonna M, Ayyoub M, Cella M, Pittet MJ, Batard P, Valmori D, Guillaume P, Liénard D, Cerottini JC, Romero P. The activatory receptor 2B4 is expressed in vivo by human CD8+ effector alpha beta T cells. J Immunol. 2001 Dec 01; 167(11):6165-70. PMID: 11714776.
    Citations: 20     Fields:    Translation:HumansCells
  134. Pittet MJ, Speiser DE, Valmori D, Rimoldi D, Liénard D, Lejeune F, Cerottini JC, Romero P. Ex vivo analysis of tumor antigen specific CD8+ T cell responses using MHC/peptide tetramers in cancer patients. Int Immunopharmacol. 2001 Jul; 1(7):1235-47. PMID: 11460305.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  135. Pittet MJ, Zippelius A, Speiser DE, Assenmacher M, Guillaume P, Valmori D, Liénard D, Lejeune F, Cerottini JC, Romero P. Ex vivo IFN-gamma secretion by circulating CD8 T lymphocytes: implications of a novel approach for T cell monitoring in infectious and malignant diseases. J Immunol. 2001 Jun 15; 166(12):7634-40. PMID: 11390521.
    Citations: 23     Fields:    Translation:HumansCells
  136. Pittet MJ, Speiser DE, Liénard D, Valmori D, Guillaume P, Dutoit V, Rimoldi D, Lejeune F, Cerottini JC, Romero P. Expansion and functional maturation of human tumor antigen-specific CD8+ T cells after vaccination with antigenic peptide. Clin Cancer Res. 2001 Mar; 7(3 Suppl):796s-803s. PMID: 11300475.
    Citations: 17     Fields:    Translation:HumansCells
  137. Speiser DE, Migliaccio M, Pittet MJ, Valmori D, Liénard D, Lejeune F, Reichenbach P, Guillaume P, Lüscher I, Cerottini JC, Romero P. Human CD8(+) T cells expressing HLA-DR and CD28 show telomerase activity and are distinct from cytolytic effector T cells. Eur J Immunol. 2001 Feb; 31(2):459-66. PMID: 11180110.
    Citations: 16     Fields:    Translation:HumansCells
  138. Valmori D, Dutoit V, Liénard D, Rimoldi D, Pittet MJ, Champagne P, Ellefsen K, Sahin U, Speiser D, Lejeune F, Cerottini JC, Romero P. Naturally occurring human lymphocyte antigen-A2 restricted CD8+ T-cell response to the cancer testis antigen NY-ESO-1 in melanoma patients. Cancer Res. 2000 Aug 15; 60(16):4499-506. PMID: 10969798.
    Citations: 45     Fields:    Translation:HumansCells
  139. Pittet MJ, Speiser DE, Valmori D, Cerottini JC, Romero P. Cutting edge: cytolytic effector function in human circulating CD8+ T cells closely correlates with CD56 surface expression. J Immunol. 2000 Feb 01; 164(3):1148-52. PMID: 10640724.
    Citations: 65     Fields:    Translation:HumansCells
  140. Romero P, Pittet MJ, Valmori D, Speiser DE, Cerundolo V, Liénard D, Lejeune F, Cerottini JC. Immune monitoring in cancer immunotherapy. Ernst Schering Res Found Workshop. 2000; (30):75-97. PMID: 10943317.
    Citations:    Fields:    Translation:HumansCells
  141. Speiser DE, Pittet MJ, Valmori D, Dunbar R, Rimoldi D, Liénard D, MacDonald HR, Cerottini JC, Cerundolo V, Romero P. In vivo expression of natural killer cell inhibitory receptors by human melanoma-specific cytolytic T lymphocytes. J Exp Med. 1999 Sep 20; 190(6):775-82. PMID: 10499916; PMCID: PMC2195637.
    Citations: 22     Fields:    Translation:HumansCells
  142. Pittet MJ, Valmori D, Dunbar PR, Speiser DE, Liénard D, Lejeune F, Fleischhauer K, Cerundolo V, Cerottini JC, Romero P. High frequencies of naive Melan-A/MART-1-specific CD8(+) T cells in a large proportion of human histocompatibility leukocyte antigen (HLA)-A2 individuals. J Exp Med. 1999 Sep 06; 190(5):705-15. PMID: 10477554; PMCID: PMC2195613.
    Citations: 130     Fields:    Translation:HumansCells
  143. Valmori D, Pittet MJ, Vonarbourg C, Rimoldi D, Liénard D, Speiser D, Dunbar R, Cerundolo V, Cerottini JC, Romero P. Analysis of the cytolytic T lymphocyte response of melanoma patients to the naturally HLA-A*0201-associated tyrosinase peptide 368-376. Cancer Res. 1999 Aug 15; 59(16):4050-5. PMID: 10463606.
    Citations: 10     Fields:    Translation:HumansCells
  144. Speiser DE, Valmori D, Rimoldi D, Pittet MJ, Liénard D, Cerundolo V, MacDonald HR, Cerottini JC, Romero P. CD28-negative cytolytic effector T cells frequently express NK receptors and are present at variable proportions in circulating lymphocytes from healthy donors and melanoma patients. Eur J Immunol. 1999 06; 29(6):1990-9. PMID: 10382762.
    Citations: 26     Fields:    Translation:HumansCells
  145. Valmori D, Pittet MJ, Rimoldi D, Liénard D, Dunbar R, Cerundolo V, Lejeune F, Cerottini JC, Romero P. An antigen-targeted approach to adoptive transfer therapy of cancer. Cancer Res. 1999 May 01; 59(9):2167-73. PMID: 10232604.
    Citations: 4     Fields:    Translation:HumansCells
  146. Romero P, Dunbar PR, Valmori D, Pittet M, Ogg GS, Rimoldi D, Chen JL, Liénard D, Cerottini JC, Cerundolo V. Ex vivo staining of metastatic lymph nodes by class I major histocompatibility complex tetramers reveals high numbers of antigen-experienced tumor-specific cytolytic T lymphocytes. J Exp Med. 1998 Nov 02; 188(9):1641-50. PMID: 9802976; PMCID: PMC2212507.
    Citations: 116     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.