Harvard Catalyst Profiles

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Brendan D. Price, Ph.D.

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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01GM114304 (PRICE, BRENDAN D) Mar 1, 2015 - Feb 28, 2021
    NIH
    Identifying the roles of DNA rewinding enzymes on maintaining genome stability
    Role: Principal Investigator
  2. R01CA177884 (PRICE, BRENDAN D) Jul 1, 2013 - Jun 30, 2019
    NIH
    Nucleosome Dynamics and the Repair of DNA Damage
    Role: Principal Investigator
  3. R21NS061669 (PRICE, BRENDAN D) Sep 30, 2007 - Aug 31, 2009
    NIH
    Identification of Inhibitors of the Tip60 Histone Acetyltransferase
    Role: Principal Investigator
  4. R01CA093602 (PRICE, BRENDAN D) Dec 1, 2001 - May 31, 2020
    NIH
    Functional analysis of the Tip60 complex
    Role: Principal Investigator
  5. R01CA064585 (PRICE, BRENDAN D) Apr 1, 1995 - Jul 31, 2018
    NIH
    Histone methylation controls activation of ATM and the radiation response
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Qi H, Grace Wright RH, Beato M, Price BD. The ADP-ribose hydrolase NUDT5 is important for DNA repair. Cell Rep. 2022 12 20; 41(12):111866. PMID: 36543120.
    Citations:    Fields:    Translation:Cells
  2. Sreekumar R, Al-Saihati H, Emaduddin M, Moutasim K, Mellone M, Patel A, Kilic S, Cetin M, Erdemir S, Navio MS, Lopez MA, Curtis N, Yagci T, Primrose JN, Price BD, Berx G, Thomas GJ, Tulchinsky E, Mirnezami A, Sayan AE. The ZEB2-dependent EMT transcriptional programme drives therapy resistance by activating nucleotide excision repair genes ERCC1 and ERCC4 in colorectal cancer. Mol Oncol. 2021 08; 15(8):2065-2083. PMID: 33931939; PMCID: PMC8333771.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  3. House NCM, Parasuram R, Layer JV, Price BD. Site-specific targeting of a light activated dCas9-KillerRed fusion protein generates transient, localized regions of oxidative DNA damage. PLoS One. 2020; 15(12):e0237759. PMID: 33332350.
    Citations: 1     Fields:    Translation:HumansCells
  4. Layer JV, Debaize L, Van Scoyk A, House NC, Brown AJ, Liu Y, Stevenson KE, Hemann M, Roberts SA, Price BD, Weinstock DM, Day TA. Polymerase d promotes chromosomal rearrangements and imprecise double-strand break repair. Proc Natl Acad Sci U S A. 2020 11 03; 117(44):27566-27577. PMID: 33077594.
    Citations: 2     Fields:    Translation:HumansCells
  5. Serafim RB, Cardoso C, Di Cristofaro LFM, Pienna Soares C, Araújo Silva W, Espreafico EM, Paçó-Larson ML, Price BD, Valente V. HJURP knockdown disrupts clonogenic capacity and increases radiation-induced cell death of glioblastoma cells. Cancer Gene Ther. 2020 05; 27(5):319-329. PMID: 31138900.
    Citations: 3     Fields:    Translation:HumansCells
  6. Qi H, Price BD, Day TA. Multiple Roles for Mono- and Poly(ADP-Ribose) in Regulating Stress Responses. Trends Genet. 2019 02; 35(2):159-172. PMID: 30595401; PMCID: PMC6338491.
    Citations: 8     Fields:    Translation:Cells
  7. Zhou J, Li J, Serafim RB, Ketchum S, Ferreira CG, Liu JC, Coe KA, Price BD, Yusufzai T. Human CHD1 is required for early DNA-damage signaling and is uniquely regulated by its N terminus. Nucleic Acids Res. 2018 05 04; 46(8):3891-3905. PMID: 29529298; PMCID: PMC5934646.
    Citations: 16     Fields:    Translation:HumansCells
  8. Gursoy-Yuzugullu O, Carman C, Price BD. Spatially restricted loading of BRD2 at DNA double-strand breaks protects H4 acetylation domains and promotes DNA repair. Sci Rep. 2017 10 10; 7(1):12921. PMID: 29018219; PMCID: PMC5635005.
    Citations: 16     Fields:    Translation:HumansCells
  9. Dhar S, Gursoy-Yuzugullu O, Parasuram R, Price BD. The tale of a tail: histone H4 acetylation and the repair of DNA breaks. Philos Trans R Soc Lond B Biol Sci. 2017 Oct 05; 372(1731). PMID: 28847821.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  10. Ströbel T, Madlener S, Tuna S, Vose S, Lagerweij T, Wurdinger T, Vierlinger K, Wöhrer A, Price BD, Demple B, Saydam O, Saydam N. Ape1 guides DNA repair pathway choice that is associated with drug tolerance in glioblastoma. Sci Rep. 2017 08 29; 7(1):9674. PMID: 28852018.
    Citations: 14     Fields:    Translation:HumansCells
  11. Day TA, Layer JV, Cleary JP, Guha S, Stevenson KE, Tivey T, Kim S, Schinzel AC, Izzo F, Doench J, Root DE, Hahn WC, Price BD, Weinstock DM. Corrigendum: PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA. Nat Commun. 2017 06 13; 8:15918. PMID: 28607496.
    Citations: 2     Fields:    
  12. Price BD. KDM5A demethylase: Erasing histone modifications to promote repair of DNA breaks. J Cell Biol. 2017 07 03; 216(7):1871-1873. PMID: 28572116; PMCID: PMC5496629.
    Citations: 4     Fields:    Translation:Cells
  13. Day TA, Layer JV, Cleary JP, Guha S, Stevenson KE, Tivey T, Kim S, Schinzel AC, Izzo F, Doench J, Root DE, Hahn WC, Price BD, Weinstock DM. PARP3 is a promoter of chromosomal rearrangements and limits G4 DNA. Nat Commun. 2017 04 27; 8:15110. PMID: 28447610; PMCID: PMC5414184.
    Citations: 18     Fields:    Translation:HumansCells
  14. Gursoy-Yuzugullu O, Carman C, Serafim RB, Myronakis M, Valente V, Price BD. Epigenetic therapy with inhibitors of histone methylation suppresses DNA damage signaling and increases glioma cell radiosensitivity. Oncotarget. 2017 Apr 11; 8(15):24518-24532. PMID: 28445939.
    Citations: 21     Fields:    Translation:HumansCells
  15. Gursoy-Yuzugullu O, House N, Price BD. Patching Broken DNA: Nucleosome Dynamics and the Repair of DNA Breaks. J Mol Biol. 2016 05 08; 428(9 Pt B):1846-60. PMID: 26625977; PMCID: PMC4860187.
    Citations: 49     Fields:    Translation:Cells
  16. Gursoy-Yuzugullu O, Ayrapetov MK, Price BD. Histone chaperone Anp32e removes H2A.Z from DNA double-strand breaks and promotes nucleosome reorganization and DNA repair. Proc Natl Acad Sci U S A. 2015 Jun 16; 112(24):7507-12. PMID: 26034280; PMCID: PMC4475971.
    Citations: 48     Fields:    Translation:HumansCells
  17. Du F, Zhang M, Li X, Yang C, Meng H, Wang D, Chang S, Xu Y, Price B, Sun Y. Dimer monomer transition and dimer re-formation play important role for ATM cellular function during DNA repair. Biochem Biophys Res Commun. 2014 Oct 03; 452(4):1034-9. PMID: 25240135.
    Citations: 3     Fields:    Translation:HumansCells
  18. Ayrapetov MK, Gursoy-Yuzugullu O, Xu C, Xu Y, Price BD. DNA double-strand breaks promote methylation of histone H3 on lysine 9 and transient formation of repressive chromatin. Proc Natl Acad Sci U S A. 2014 Jun 24; 111(25):9169-74. PMID: 24927542.
    Citations: 167     Fields:    Translation:HumansCells
  19. Park E, Kim H, Kim JM, Primack B, Vidal-Cardenas S, Xu Y, Price BD, Mills AA, D'Andrea AD. FANCD2 activates transcription of TAp63 and suppresses tumorigenesis. Mol Cell. 2013 Jun 27; 50(6):908-18. PMID: 23806336.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  20. Price BD, D'Andrea AD. Chromatin remodeling at DNA double-strand breaks. Cell. 2013 Mar 14; 152(6):1344-54. PMID: 23498941.
    Citations: 262     Fields:    Translation:HumansAnimalsCells
  21. Berbeco RI, Korideck H, Ngwa W, Kumar R, Patel J, Sridhar S, Johnson S, Price BD, Kimmelman A, Makrigiorgos GM. DNA damage enhancement from gold nanoparticles for clinical MV photon beams. Radiat Res. 2012 Dec; 178(6):604-8. PMID: 23148509; PMCID: PMC3525114.
    Citations: 35     Fields:    Translation:HumansCells
  22. Xu Y, Ayrapetov MK, Xu C, Gursoy-Yuzugullu O, Hu Y, Price BD. Histone H2A.Z controls a critical chromatin remodeling step required for DNA double-strand break repair. Mol Cell. 2012 Dec 14; 48(5):723-33. PMID: 23122415.
    Citations: 144     Fields:    Translation:HumansCells
  23. Xu C, Xu Y, Gursoy-Yuzugullu O, Price BD. The histone variant macroH2A1.1 is recruited to DSBs through a mechanism involving PARP1. FEBS Lett. 2012 Nov 02; 586(21):3920-5. PMID: 23031826; PMCID: PMC3491562.
    Citations: 39     Fields:    Translation:HumansCells
  24. Xu Y, Xu C, Price BD. Mechanistic links between ATM and histone methylation codes during DNA repair. Prog Mol Biol Transl Sci. 2012; 110:263-88. PMID: 22749149.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  25. Xu Y, Parmar K, Du F, Price BD, Sun Y. The radioprotective agent WR1065 protects cells from radiation damage by regulating the activity of the Tip60 acetyltransferase. Int J Biochem Mol Biol. 2011; 2(4):295-302. PMID: 22187663.
    Citations:    
  26. Ayrapetov MK, Xu C, Sun Y, Zhu K, Parmar K, D'Andrea AD, Price BD. Activation of Hif1a by the prolylhydroxylase inhibitor dimethyoxalyglycine decreases radiosensitivity. PLoS One. 2011; 6(10):e26064. PMID: 22016813.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  27. Xu Y, Price BD. Chromatin dynamics and the repair of DNA double strand breaks. Cell Cycle. 2011 Jan 15; 10(2):261-7. PMID: 21212734.
    Citations: 85     Fields:    Translation:Cells
  28. Xu Y, Sun Y, Jiang X, Ayrapetov MK, Moskwa P, Yang S, Weinstock DM, Price BD. The p400 ATPase regulates nucleosome stability and chromatin ubiquitination during DNA repair. J Cell Biol. 2010 Oct 04; 191(1):31-43. PMID: 20876283.
    Citations: 107     Fields:    Translation:HumansCells
  29. Weng D, Cunin MC, Song B, Price BD, Eller MS, Gilchrest BA, Calderwood SK, Gong J. Radiosensitization of mammary carcinoma cells by telomere homolog oligonucleotide pretreatment. Breast Cancer Res. 2010; 12(5):R71. PMID: 20846433.
    Citations: 9     Fields:    Translation:AnimalsCells
  30. Lin CI, Whang EE, Donner DB, Du J, Lorch J, He F, Jiang X, Price BD, Moore FD, Ruan DT. Autophagy induction with RAD001 enhances chemosensitivity and radiosensitivity through Met inhibition in papillary thyroid cancer. Mol Cancer Res. 2010 Sep; 8(9):1217-26. PMID: 20736296.
    Citations: 50     Fields:    Translation:HumansCells
  31. Jiang X, Xu Y, Price BD. Acetylation of H2AX on lysine 36 plays a key role in the DNA double-strand break repair pathway. FEBS Lett. 2010 Jul 02; 584(13):2926-30. PMID: 20488183.
    Citations: 14     Fields:    Translation:HumansCells
  32. Sun Y, Jiang X, Price BD. Tip60: connecting chromatin to DNA damage signaling. Cell Cycle. 2010 Mar 01; 9(5):930-6. PMID: 20160506; PMCID: PMC2901859.
    Citations: 89     Fields:    Translation:HumansCells
  33. Lin CI, Whang EE, Abramson MA, Jiang X, Price BD, Donner DB, Moore FD, Ruan DT. Autophagy: a new target for advanced papillary thyroid cancer therapy. Surgery. 2009 Dec; 146(6):1208-14. PMID: 19958950.
    Citations: 22     Fields:    Translation:HumansCells
  34. Kim K, Pollard JM, Norris AJ, McDonald JT, Sun Y, Micewicz E, Pettijohn K, Damoiseaux R, Iwamoto KS, Sayre JW, Price BD, Gatti RA, McBride WH. High-throughput screening identifies two classes of antibiotics as radioprotectors: tetracyclines and fluoroquinolones. Clin Cancer Res. 2009 Dec 01; 15(23):7238-45. PMID: 19920105.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  35. Lin CI, Whang EE, Donner DB, Jiang X, Price BD, Carothers AM, Delaine T, Leffler H, Nilsson UJ, Nose V, Moore FD, Ruan DT. Galectin-3 targeted therapy with a small molecule inhibitor activates apoptosis and enhances both chemosensitivity and radiosensitivity in papillary thyroid cancer. Mol Cancer Res. 2009 Oct; 7(10):1655-62. PMID: 19825987.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  36. Sun Y, Jiang X, Xu Y, Ayrapetov MK, Moreau LA, Whetstine JR, Price BD. Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60. Nat Cell Biol. 2009 Nov; 11(11):1376-82. PMID: 19783983; PMCID: PMC2783526.
    Citations: 230     Fields:    Translation:HumansCells
  37. Sun Y, Xu Y, Roy K, Price BD. DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity. Mol Cell Biol. 2007 Dec; 27(24):8502-9. PMID: 17923702; PMCID: PMC2169409.
    Citations: 142     Fields:    Translation:HumansCells
  38. Fernandes ND, Sun Y, Price BD. Activation of the kinase activity of ATM by retinoic acid is required for CREB-dependent differentiation of neuroblastoma cells. J Biol Chem. 2007 Jun 01; 282(22):16577-84. PMID: 17426037.
    Citations: 24     Fields:    Translation:HumansCells
  39. Sun Y, Jiang X, Chen S, Price BD. Inhibition of histone acetyltransferase activity by anacardic acid sensitizes tumor cells to ionizing radiation. FEBS Lett. 2006 Aug 07; 580(18):4353-6. PMID: 16844118.
    Citations: 88     Fields:    Translation:HumansCells
  40. Roy K, Wang L, Makrigiorgos GM, Price BD. Methylation of the ATM promoter in glioma cells alters ionizing radiation sensitivity. Biochem Biophys Res Commun. 2006 Jun 09; 344(3):821-6. PMID: 16631604.
    Citations: 28     Fields:    Translation:HumansCells
  41. Jiang X, Sun Y, Chen S, Roy K, Price BD. The FATC domains of PIKK proteins are functionally equivalent and participate in the Tip60-dependent activation of DNA-PKcs and ATM. J Biol Chem. 2006 Jun 09; 281(23):15741-6. PMID: 16603769.
    Citations: 54     Fields:    Translation:HumansCells
  42. Sun Y, Jiang X, Chen S, Fernandes N, Price BD. A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM. Proc Natl Acad Sci U S A. 2005 Sep 13; 102(37):13182-7. PMID: 16141325; PMCID: PMC1197271.
    Citations: 342     Fields:    Translation:HumansCells
  43. Fernandes N, Sun Y, Chen S, Paul P, Shaw RJ, Cantley LC, Price BD. DNA damage-induced association of ATM with its target proteins requires a protein interaction domain in the N terminus of ATM. J Biol Chem. 2005 Apr 15; 280(15):15158-64. PMID: 15713674.
    Citations: 35     Fields:    Translation:HumansCells
  44. Wang G, Brennan C, Rook M, Wolfe JL, Leo C, Chin L, Pan H, Liu WH, Price B, Makrigiorgos GM. Balanced-PCR amplification allows unbiased identification of genomic copy changes in minute cell and tissue samples. Nucleic Acids Res. 2004 May 21; 32(9):e76. PMID: 15155823; PMCID: PMC419625.
    Citations: 22     Fields:    Translation:HumansCells
  45. Chen S, Wang G, Makrigiorgos GM, Price BD. Stable siRNA-mediated silencing of ATM alters the transcriptional profile of HeLa cells. Biochem Biophys Res Commun. 2004 May 14; 317(4):1037-44. PMID: 15094373.
    Citations: 11     Fields:    Translation:HumansCells
  46. Chen S, Paul P, Price BD. ATM's leucine-rich domain and adjacent sequences are essential for ATM to regulate the DNA damage response. Oncogene. 2003 Sep 25; 22(41):6332-9. PMID: 14508513.
    Citations: 3     Fields:    Translation:HumansCells
  47. Kaur M, Zhang Y, Liu WH, Tetradis S, Price BD, Makrigiorgos GM. Ligation of a primer at a mutation: a method to detect low level mutations in DNA. Mutagenesis. 2002 Sep; 17(5):365-74. PMID: 12202623.
    Citations: 5     Fields:    Translation:HumansCells
  48. Makrigiorgos GM, Chakrabarti S, Zhang Y, Kaur M, Price BD. A PCR-based amplification method retaining the quantitative difference between two complex genomes. Nat Biotechnol. 2002 Sep; 20(9):936-9. PMID: 12161758.
    Citations: 20     Fields:    Translation:Humans
  49. Zhang Y, Kaur M, Price BD, Tetradis S, Makrigiorgos GM. An amplification and ligation-based method to scan for unknown mutations in DNA. Hum Mutat. 2002 Aug; 20(2):139-47. PMID: 12124995.
    Citations: 5     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.