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Stephanie Rachel Jost, Ph.D.


Givaudan-Roure award in physics and chemistry
Arditi award for outstanding Master’s Thesis in Biology
2008 - 2009
Prospective Researcher Fellowship, Swiss National Science Foundation
2009 - 2010
Postdoctoral fellowship award from the MGH ECOR Fund for Medical Discovery
2012 - 2013
Harvard University Center for AIDS Research Center (HU CFAR) Scholar Award


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01NS116278 (TAN, CHEN SABRINA) Apr 15, 2020 - Jan 31, 2025
    NK cell responses to JC polyomavirus
    Role: Co-Principal Investigator
  2. R21AI137835 (JOST, STEPHANIE) May 17, 2018 - Apr 30, 2020
    Influenza-specific memory responses mediated by human NK cells
    Role: Principal Investigator
  3. R01AI116363 (JOST, STEPHANIE) Jan 1, 2017 - Dec 31, 2018
    HIV-specific responses mediated by human NK cells
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. DeWolfe D, Aid M, McGann K, Ghofrani J, Geiger E, Helzer C, Malik S, Kleiboeker S, Jost S, Tan CS. NK Cells Contribute to the Immune Risk Profile in Kidney Transplant Candidates. Front Immunol. 2019; 10:1890. PMID: 31507586.
  2. Lucar O, Reeves RK, Jost S. A Natural Impact: NK Cells at the Intersection of Cancer and HIV Disease. Front Immunol. 2019; 10:1850. PMID: 31474977.
  3. Ghofrani J, Lucar O, Dugan H, Reeves RK, Jost S. Semaphorin 7A modulates cytokine-induced memory-like responses by human natural killer cells. Eur J Immunol. 2019 08; 49(8):1153-1166. PMID: 31016720.
  4. Manickam C, Nwanze C, Ram DR, Shah SV, Smith S, Jones R, Hueber B, Kroll K, Varner V, Goepfert P, Jost S, Reeves RK. Progressive lentivirus infection induces natural killer cell receptor-expressing B cells in the gastrointestinal tract. AIDS. 2018 07 31; 32(12):1571-1578. PMID: 29734222.
    Citations:    Fields:    
  5. Palmer CD, Romero-Tejeda M, Scully EP, Lockhart A, Seaman MS, Goldenthal A, Piechocka-Trocha A, Walker BD, Chibnik LB, Jost S, Porichis F. Increased frequencies of CD8+CD57+ T cells are associated with antibody neutralization breadth against HIV in viraemic controllers. J Int AIDS Soc. 2016; 19(1):21136. PMID: 27938646.
    Citations: 1     Fields:    Translation:HumansCells
  6. Garcia-Beltran WF, Hölzemer A, Martrus G, Chung AW, Pacheco Y, Simoneau CR, Rucevic M, Lamothe-Molina PA, Pertel T, Kim TE, Dugan H, Alter G, Dechanet-Merville J, Jost S, Carrington M, Altfeld M. Open conformers of HLA-F are high-affinity ligands of the activating NK-cell receptor KIR3DS1. Nat Immunol. 2016 09; 17(9):1067-74. PMID: 27455421.
    Citations: 29     Fields:    Translation:HumansCells
  7. Palmer CD, Romero-Tejeda M, Sirignano M, Sharma S, Allen TM, Altfeld M, Jost S. Naturally Occurring Subclinical Endotoxemia in Humans Alters Adaptive and Innate Immune Functions through Reduced MAPK and Increased STAT1 Phosphorylation. J Immunol. 2016 Jan 15; 196(2):668-77. PMID: 26643479.
    Citations: 2     Fields:    Translation:HumansCells
  8. Henrich TJ, Hanhauser E, Harrison LJ, Palmer CD, Romero-Tejeda M, Jost S, Bosch RJ, Kuritzkes DR. CCR5-?32 Heterozygosity, HIV-1 Reservoir Size, and Lymphocyte Activation in Individuals Receiving Long-term Suppressive Antiretroviral Therapy. J Infect Dis. 2016 Mar 01; 213(5):766-70. PMID: 26512140.
    Citations: 1     Fields:    Translation:HumansCells
  9. Reeves RK, Li H, Jost S, Blass E, Li H, Schafer JL, Varner V, Manickam C, Eslamizar L, Altfeld M, von Andrian UH, Barouch DH. Antigen-specific NK cell memory in rhesus macaques. Nat Immunol. 2015 Sep; 16(9):927-32. PMID: 26193080.
    Citations: 50     Fields:    Translation:AnimalsCells
  10. Reeves RK, Li H, Blass E, Li H, Jost S, Altfeld M, Barouch D. SIV- and Vaccine-elicited NK Cell Memory in Rhesus Macaques. AIDS Res Hum Retroviruses. 2014 Oct; 30 Suppl 1:A14. PMID: 25357389.
  11. Körner C, Granoff ME, Amero MA, Sirignano MN, Vaidya SA, Jost S, Allen TM, Rosenberg ES, Altfeld M. Increased frequency and function of KIR2DL1-3? NK cells in primary HIV-1 infection are determined by HLA-C group haplotypes. Eur J Immunol. 2014 Oct; 44(10):2938-48. PMID: 25043727.
    Citations: 12     Fields:    Translation:HumansCells
  12. Jost S, Tomezsko PJ, Rands K, Toth I, Lichterfeld M, Gandhi RT, Altfeld M. CD4+ T-cell help enhances NK cell function following therapeutic HIV-1 vaccination. J Virol. 2014 Aug; 88(15):8349-54. PMID: 24829350.
    Citations: 12     Fields:    Translation:HumansCellsPHPublic Health
  13. Jost S, Moreno-Nieves UY, Garcia-Beltran WF, Rands K, Reardon J, Toth I, Piechocka-Trocha A, Altfeld M, Addo MM. Dysregulated Tim-3 expression on natural killer cells is associated with increased Galectin-9 levels in HIV-1 infection. Retrovirology. 2013 Jul 18; 10:74. PMID: 23866914.
    Citations: 15     Fields:    Translation:HumansCells
  14. Jost S, Altfeld M. Control of human viral infections by natural killer cells. Annu Rev Immunol. 2013; 31:163-94. PMID: 23298212.
    Citations: 99     Fields:    Translation:HumansAnimalsCells
  15. Jost S, Altfeld M, Chang JJ. Harnessing innate and adaptive immunity for viral vaccine design. Expert Rev Vaccines. 2012 Jul; 11(7):775-7. PMID: 22913253.
    Citations:    Fields:    Translation:HumansAnimalsCellsPHPublic Health
  16. Jost S, Altfeld M. Evasion from NK cell-mediated immune responses by HIV-1. Microbes Infect. 2012 Sep; 14(11):904-15. PMID: 22626930.
    Citations: 20     Fields:    Translation:HumansCells
  17. Jost S, Quillay H, Reardon J, Peterson E, Simmons RP, Parry BA, Bryant NN, Binder WD, Altfeld M. Changes in cytokine levels and NK cell activation associated with influenza. PLoS One. 2011; 6(9):e25060. PMID: 21966414.
    Citations: 20     Fields:    Translation:HumansCells
  18. Jost S, Reardon J, Peterson E, Poole D, Bosch R, Alter G, Altfeld M. Expansion of 2B4+ natural killer (NK) cells and decrease in NKp46+ NK cells in response to influenza. Immunology. 2011 Apr; 132(4):516-26. PMID: 21214542.
    Citations: 11     Fields:    Translation:HumansCellsPHPublic Health
  19. Ackerman ME, Moldt B, Wyatt RT, Dugast AS, McAndrew E, Tsoukas S, Jost S, Berger CT, Sciaranghella G, Liu Q, Irvine DJ, Burton DR, Alter G. A robust, high-throughput assay to determine the phagocytic activity of clinical antibody samples. J Immunol Methods. 2011 Mar 07; 366(1-2):8-19. PMID: 21192942.
    Citations: 69     Fields:    Translation:HumansCells
  20. Alter G*, Jost S*, Rihn S, Reyor LL, Nolan BE, Ghebremichael M, Bosch R, Altfeld M, Lauer GM. *co-first authors. Reduced frequencies of NKp30+NKp46+, CD161+ and NKG2D+ NK cells in acute HCV infection may predict viral clearance. J Hepatol. . 2010.
  21. Nolting A, Dugast AS, Rihn S, Luteijn R, Carrington MF, Kane K, Jost S, Toth I, Nagami E, Faetkenheuer G, Hartmann P, Altfeld M, Alter G. MHC class I chain-related protein A shedding in chronic HIV-1 infection is associated with profound NK cell dysfunction. Virology. 2010 Oct 10; 406(1):12-20. PMID: 20667578.
    Citations: 13     Fields:    Translation:HumansCells
  22. Turelli P, Liagre-Quazzola A, Mangeat B, Verp S, Jost S, Trono D. APOBEC3-independent interferon-induced viral clearance in hepatitis B virus transgenic mice. J Virol. 2008 Jul; 82(13):6585-90. PMID: 18434399.
    Citations: 10     Fields:    Translation:AnimalsCells
  23. Jost S, Turelli P, Mangeat B, Protzer U, Trono D. Induction of antiviral cytidine deaminases does not explain the inhibition of hepatitis B virus replication by interferons. J Virol. 2007 Oct; 81(19):10588-96. PMID: 17652382.
    Citations: 22     Fields:    Translation:HumansCells
  24. Yerly S, Jost S, Monnat M, Telenti A, Cavassini M, Chave JP, Kaiser L, Burgisser P, Perrin L. HIV-1 co/super-infection in intravenous drug users. AIDS. 2004 Jul 02; 18(10):1413-21. PMID: 15199317.
    Citations: 22     Fields:    Translation:HumansCells
  25. Yerly S, Jost S, Telenti A, Flepp M, Kaiser L, Chave JP, Vernazza P, Battegay M, Furrer H, Chanzy B, Burgisser P, Rickenbach M, Gebhardt M, Bernard MC, Perneger T, Hirschel B, Perrin L. Infrequent transmission of HIV-1 drug-resistant variants. Antivir Ther. 2004 Jun; 9(3):375-84. PMID: 15259900.
    Citations: 17     Fields:    Translation:HumansCells
  26. Turelli P*, Jost S*, Mangeat B, Trono D. *co-first authors. Response to Comment on "Inhibition of Hepatitis B Virus Replication by APOBEC3G". Science. 305(5689):1403b . 2004.
  27. Turelli P*, Mangeat B*, Jost S*, Vianin S, Trono D. *co-first authors. Inhibition of hepatitis B virus replication by APOBEC3G. Science. Mar 19; 303(5665):1829. 2004.
  28. Jost S, Bernard MC, Kaiser L, Yerly S, Hirschel B, Samri A, Autran B, Goh LE, Perrin L. A patient with HIV-1 superinfection. N Engl J Med. 2002 Sep 05; 347(10):731-6. PMID: 12213944.
    Citations: 63     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.