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profileMarc W. Kirschner, Ph.D.

TitleJohn Franklin Enders University Professor of Systems Biology
InstitutionHarvard Medical School
DepartmentSystems Biology
AddressHarvard Medical School
Alpert 536, Systems Biology
200 Longwood Ave
Boston MA 02115
Phone617/432-2250
Fax617/432-0420
vCardDownload vCard (login for email)
Other Positions
TitleHead of the Department of Systems Biology
InstitutionHarvard Medical School
DepartmentSystems Biology


Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R21HD087723     (KIRSCHNER, MARC WALLACE)Mar 4, 2016 - Feb 28, 2018
NIH/NICHD
Studies of Direct Pluripotent Stem Cell Programming
Role: Principal Investigator

R01HD073104     (KIRSCHNER, MARC WALLACE)Sep 1, 2012 - May 31, 2022
NIH/NICHD
Systems Analysis of cell type differentiation in Xenopus development
Role: Principal Investigator

R21DK098818     (KIRSCHNER, MARC WALLACE)Sep 1, 2012 - Aug 31, 2014
NIH/NIDDK
A high-throughput method for simultaneous profiling of mRNA and protein levels in
Role: Principal Investigator

R01HD091846     (KIRSCHNER, MARC WALLACE)Aug 16, 2012 - Feb 28, 2022
NIH/NICHD
Proteomics of Cell Signaling in Embryogenesis.
Role: Principal Investigator

R01GM103785     (KIRSCHNER, MARC WALLACE)Aug 15, 2012 - Jun 30, 2017
NIH/NIGMS
Cell Cycle proteomicsin Xenopus
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Lee HJ, Jedrychowski MP, Vinayagam A, Wu N, Shyh-Chang N, Hu Y, Min-Wen C, Moore JK, Asara JM, Lyssiotis CA, Perrimon N, Gygi SP, Cantley LC, Kirschner MW. Proteomic and Metabolomic Characterization of a Mammalian Cellular Transition from Quiescence to Proliferation. Cell Rep. 2017 Jul 18; 20(3):721-736. PMID: 28723573.
    View in: PubMed
  2. Lu Y, Wu J, Dong Y, Chen S, Sun S, Ma YB, Ouyang Q, Finley D, Kirschner MW, Mao Y. Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle. Mol Cell. 2017 Jul 20; 67(2):322-333.e6. PMID: 28689658.
    View in: PubMed
  3. Gujral TS, Kirschner MW. Hippo pathway mediates resistance to cytotoxic drugs. Proc Natl Acad Sci U S A. 2017 May 02; 114(18):E3729-E3738. PMID: 28416665.
    View in: PubMed
  4. Wan L, Chen M, Cao J, Dai X, Yin Q, Zhang J, Song SJ, Lu Y, Liu J, Inuzuka H, Katon JM, Berry K, Fung J, Ng C, Liu P, Song MS, Xue L, Bronson RT, Kirschner MW, Cui R, Pandolfi PP, Wei W. The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function. Cancer Discov. 2017 Apr; 7(4):424-441. PMID: 28174173.
    View in: PubMed
  5. Chen S, Wu J, Lu Y, Ma YB, Lee BH, Yu Z, Ouyang Q, Finley DJ, Kirschner MW, Mao Y. Structural basis for dynamic regulation of the human 26S proteasome. Proc Natl Acad Sci U S A. 2016 Nov 15; 113(46):12991-12996. PMID: 27791164.
    View in: PubMed
  6. Brown NG, VanderLinden R, Watson ER, Weissmann F, Ordureau A, Wu KP, Zhang W, Yu S, Mercredi PY, Harrison JS, Davidson IF, Qiao R, Lu Y, Dube P, Brunner MR, Grace CRR, Miller DJ, Haselbach D, Jarvis MA, Yamaguchi M, Yanishevski D, Petzold G, Sidhu SS, Kuhlman B, Kirschner MW, Harper JW, Peters JM, Stark H, Schulman BA. Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C. Cell. 2016 Jun 02; 165(6):1440-1453. PMID: 27259151; PMCID: PMC4991212.
  7. Berg JM, Bhalla N, Bourne PE, Chalfie M, Drubin DG, Fraser JS, Greider CW, Hendricks M, Jones C, Kiley R, King S, Kirschner MW, Krumholz HM, Lehmann R, Leptin M, Pulverer B, Rosenzweig B, Spiro JE, Stebbins M, Strasser C, Swaminathan S, Turner P, Vale RD, VijayRaghavan K, Wolberger C. SCIENTIFIC COMMUNITY. Preprints for the life sciences. Science. 2016 May 20; 352(6288):899-901. PMID: 27199406.
    View in: PubMed
  8. Hanschen ER, Marriage TN, Ferris PJ, Hamaji T, Toyoda A, Fujiyama A, Neme R, Noguchi H, Minakuchi Y, Suzuki M, Kawai-Toyooka H, Smith DR, Sparks H, Anderson J, Bakaric R, Luria V, Karger A, Kirschner MW, Durand PM, Michod RE, Nozaki H, Olson BJ. The Gonium pectorale genome demonstrates co-option of cell cycle regulation during the evolution of multicellularity. Nat Commun. 2016 Apr 22; 7:11370. PMID: 27102219; PMCID: PMC4844696.
  9. Kaifie A, Kirschner M, Wolf D, Maintz C, Hänel M, Gattermann N, Gökkurt E, Platzbecker U, Hollburg W, Göthert JR, Parmentier S, Lang F, Hansen R, Isfort S, Schmitt K, Jost E, Serve H, Ehninger G, Berdel WE, Brümmendorf TH, Koschmieder S. Bleeding, thrombosis, and anticoagulation in myeloproliferative neoplasms (MPN): analysis from the German SAL-MPN-registry. J Hematol Oncol. 2016 Mar 05; 9:18. PMID: 26944254; PMCID: PMC4779229.
  10. Lowe CJ, Terasaki M, Wu M, Freeman RM, Runft L, Kwan K, Haigo S, Aronowicz J, Lander E, Gruber C, Smith M, Kirschner M, Gerhart J. Correction: Dorsoventral Patterning in Hemichordates: Insights into Early Chordate Evolution. PLoS Biol. 2015 Dec; 13(12):e1002354. PMID: 26714185; PMCID: PMC4700970.
  11. Son S, Kang JH, Oh S, Kirschner MW, Mitchison TJ, Manalis S. Resonant microchannel volume and mass measurements show that suspended cells swell during mitosis. J Cell Biol. 2015 Nov 23; 211(4):757-63. PMID: 26598613; PMCID: PMC4657169 [Available on 05/23/16].
  12. Simakov O, Kawashima T, Marlétaz F, Jenkins J, Koyanagi R, Mitros T, Hisata K, Bredeson J, Shoguchi E, Gyoja F, Yue JX, Chen YC, Freeman RM, Sasaki A, Hikosaka-Katayama T, Sato A, Fujie M, Baughman KW, Levine J, Gonzalez P, Cameron C, Fritzenwanker JH, Pani AM, Goto H, Kanda M, Arakaki N, Yamasaki S, Qu J, Cree A, Ding Y, Dinh HH, Dugan S, Holder M, Jhangiani SN, Kovar CL, Lee SL, Lewis LR, Morton D, Nazareth LV, Okwuonu G, Santibanez J, Chen R, Richards S, Muzny DM, Gillis A, Peshkin L, Wu M, Humphreys T, Su YH, Putnam NH, Schmutz J, Fujiyama A, Yu JK, Tagawa K, Worley KC, Gibbs RA, Kirschner MW, Lowe CJ, Satoh N, Rokhsar DS, Gerhart J. Hemichordate genomes and deuterostome origins. Nature. 2015 Nov 26; 527(7579):459-65. PMID: 26580012; PMCID: PMC4729200.
  13. Peshkin L, Wühr M, Pearl E, Haas W, Freeman RM, Gerhart JC, Klein AM, Horb M, Gygi SP, Kirschner MW. On the Relationship of Protein and mRNA Dynamics in Vertebrate Embryonic Development. Dev Cell. 2015 Nov 09; 35(3):383-94. PMID: 26555057; PMCID: PMC4776761 [Available on 11/09/16].
  14. Wühr M, Güttler T, Peshkin L, McAlister GC, Sonnett M, Ishihara K, Groen AC, Presler M, Erickson BK, Mitchison TJ, Kirschner MW, Gygi SP. The Nuclear Proteome of a Vertebrate. Curr Biol. 2015 Oct 19; 25(20):2663-71. PMID: 26441354; PMCID: PMC4618192 [Available on 10/19/16].
  15. Klein AM, Mazutis L, Akartuna I, Tallapragada N, Veres A, Li V, Peshkin L, Weitz DA, Kirschner MW. Droplet barcoding for single-cell transcriptomics applied to embryonic stem cells. Cell. 2015 May 21; 161(5):1187-201. PMID: 26000487; PMCID: PMC4441768.
  16. Ginzberg MB, Kafri R, Kirschner M. Cell biology. On being the right (cell) size. Science. 2015 May 15; 348(6236):1245075. PMID: 25977557; PMCID: PMC4533982.
  17. Lu Y, Lee BH, King RW, Finley D, Kirschner MW. Substrate degradation by the proteasome: a single-molecule kinetic analysis. Science. 2015 Apr 10; 348(6231):1250834. PMID: 25859050; PMCID: PMC4450770.
  18. Lu Y, Wang W, Kirschner MW. Specificity of the anaphase-promoting complex: a single-molecule study. Science. 2015 Apr 10; 348(6231):1248737. PMID: 25859049; PMCID: PMC4449139.
  19. Alberts B, Kirschner MW, Tilghman S, Varmus H. Opinion: Addressing systemic problems in the biomedical research enterprise. Proc Natl Acad Sci U S A. 2015 Feb 17; 112(7):1912-3. PMID: 25691698; PMCID: PMC4343141.
  20. Gujral TS, Chan M, Peshkin L, Sorger PK, Kirschner MW, MacBeath G. A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis. Cell. 2014 Nov 06; 159(4):844-56. PMID: 25417160; PMCID: PMC4243058.
  21. Satoh N, Tagawa K, Lowe CJ, Yu JK, Kawashima T, Takahashi H, Ogasawara M, Kirschner M, Hisata K, Su YH, Gerhart J. On a possible evolutionary link of the stomochord of hemichordates to pharyngeal organs of chordates. Genesis. 2014 Dec; 52(12):925-34. PMID: 25303744.
    View in: PubMed
  22. Zhao R, Deibler RW, Lerou PH, Ballabeni A, Heffner GC, Cahan P, Unternaehrer JJ, Kirschner MW, Daley GQ. A nontranscriptional role for Oct4 in the regulation of mitotic entry. Proc Natl Acad Sci U S A. 2014 Nov 04; 111(44):15768-73. PMID: 25324523; PMCID: PMC4226071.
  23. Thompson JW, Nagel J, Hoving S, Gerrits B, Bauer A, Thomas JR, Kirschner MW, Schirle M, Luchansky SJ. Quantitative Lys-?-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1. J Biol Chem. 2014 Oct 17; 289(42):28942-55. PMID: 25147182; PMCID: PMC4200252.
  24. Wang W, Wu T, Kirschner MW. The master cell cycle regulator APC-Cdc20 regulates ciliary length and disassembly of the primary cilium. Elife. 2014 Aug 19; 3:e03083. PMID: 25139956; PMCID: PMC4135350.
  25. Merbl Y, Kirschner MW. Post-Translational Modification Profiling--a High-Content Assay for Identifying Protein Modifications in Mammalian Cellular Systems. Curr Protoc Protein Sci. 2014 Aug 01; 77:27.8.1-13. PMID: 25081743; PMCID: PMC4157593.
  26. Wühr M, Freeman RM, Presler M, Horb ME, Peshkin L, Gygi S, Kirschner MW. Deep proteomics of the Xenopus laevis egg using an mRNA-derived reference database. Curr Biol. 2014 Jul 07; 24(13):1467-1475. PMID: 24954049; PMCID: PMC4090281.
  27. Li VC, Kirschner MW. Molecular ties between the cell cycle and differentiation in embryonic stem cells. Proc Natl Acad Sci U S A. 2014 Jul 01; 111(26):9503-8. PMID: 24979803; PMCID: PMC4084474.
  28. Wan L, Tan M, Yang J, Inuzuka H, Dai X, Wu T, Liu J, Shaik S, Chen G, Deng J, Malumbres M, Letai A, Kirschner MW, Sun Y, Wei W. APC(Cdc20) suppresses apoptosis through targeting Bim for ubiquitination and destruction. Dev Cell. 2014 May 27; 29(4):377-91. PMID: 24871945; PMCID: PMC4081014.
  29. Alberts B, Kirschner MW, Tilghman S, Varmus H. Rescuing US biomedical research from its systemic flaws. Proc Natl Acad Sci U S A. 2014 Apr 22; 111(16):5773-7. PMID: 24733905; PMCID: PMC4000813.
  30. Gujral TS, Peshkin L, Kirschner MW. Exploiting polypharmacology for drug target deconvolution. Proc Natl Acad Sci U S A. 2014 Apr 01; 111(13):5048-53. PMID: 24707051; PMCID: PMC3977247.
  31. Ortiz-Meoz RF, Merbl Y, Kirschner MW, Walker S. Microarray discovery of new OGT substrates: the medulloblastoma oncogene OTX2 is O-GlcNAcylated. J Am Chem Soc. 2014 Apr 02; 136(13):4845-8. PMID: 24580054; PMCID: PMC3988687.
  32. Liu P, Begley M, Michowski W, Inuzuka H, Ginzberg M, Gao D, Tsou P, Gan W, Papa A, Kim BM, Wan L, Singh A, Zhai B, Yuan M, Wang Z, Gygi SP, Lee TH, Lu KP, Toker A, Pandolfi PP, Asara JM, Kirschner MW, Sicinski P, Cantley L, Wei W. Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus. Nature. 2014 Apr 24; 508(7497):541-5. PMID: 24670654; PMCID: PMC4076493.
  33. Kirschner M. Beyond Darwin: evolvability and the generation of novelty. BMC Biol. 2013 Nov 07; 11:110. PMID: 24228732; PMCID: PMC4225857.
  34. Sung Y, Tzur A, Oh S, Choi W, Li V, Dasari RR, Yaqoob Z, Kirschner MW. Size homeostasis in adherent cells studied by synthetic phase microscopy. Proc Natl Acad Sci U S A. 2013 Oct 08; 110(41):16687-92. PMID: 24065823; PMCID: PMC3799364.
  35. Fukushima H, Ogura K, Wan L, Lu Y, Li V, Gao D, Liu P, Lau AW, Wu T, Kirschner MW, Inuzuka H, Wei W. SCF-mediated Cdh1 degradation defines a negative feedback system that coordinates cell-cycle progression. Cell Rep. 2013 Aug 29; 4(4):803-16. PMID: 23972993; PMCID: PMC3839583.
  36. Ballabeni A, Zamponi R, Moore JK, Helin K, Kirschner MW. Geminin deploys multiple mechanisms to regulate Cdt1 before cell division thus ensuring the proper execution of DNA replication. Proc Natl Acad Sci U S A. 2013 Jul 23; 110(30):E2848-53. PMID: 23836640; PMCID: PMC3725105.
  37. Wang W, Kirschner MW. Emi1 preferentially inhibits ubiquitin chain elongation by the anaphase-promoting complex. Nat Cell Biol. 2013 Jul; 15(7):797-806. PMID: 23708001; PMCID: PMC3812805.
  38. Gallop JL, Walrant A, Cantley LC, Kirschner MW. Phosphoinositides and membrane curvature switch the mode of actin polymerization via selective recruitment of toca-1 and Snx9. Proc Natl Acad Sci U S A. 2013 Apr 30; 110(18):7193-8. PMID: 23589871; PMCID: PMC3645562.
  39. Cooper KL, Oh S, Sung Y, Dasari RR, Kirschner MW, Tabin CJ. Multiple phases of chondrocyte enlargement underlie differences in skeletal proportions. Nature. 2013 Mar 21; 495(7441):375-8. PMID: 23485973; PMCID: PMC3606657.
  40. Merbl Y, Refour P, Patel H, Springer M, Kirschner MW. Profiling of ubiquitin-like modifications reveals features of mitotic control. Cell. 2013 Feb 28; 152(5):1160-72. PMID: 23452859; PMCID: PMC3711129.
  41. Kafri R, Levy J, Ginzberg MB, Oh S, Lahav G, Kirschner MW. Dynamics extracted from fixed cells reveal feedback linking cell growth to cell cycle. Nature. 2013 Feb 28; 494(7438):480-3. PMID: 23446419; PMCID: PMC3730528.
  42. Xie Y, Avello M, Schirle M, McWhinnie E, Feng Y, Bric-Furlong E, Wilson C, Nathans R, Zhang J, Kirschner MW, Huang SM, Cong F. Deubiquitinase FAM/USP9X interacts with the E3 ubiquitin ligase SMURF1 protein and protects it from ligase activity-dependent self-degradation. J Biol Chem. 2013 Feb 01; 288(5):2976-85. PMID: 23184937; PMCID: PMC3561522.
  43. Hernández AR, Klein AM, Kirschner MW. Kinetic responses of ß-catenin specify the sites of Wnt control. Science. 2012 Dec 07; 338(6112):1337-40. PMID: 23138978.
    View in: PubMed
  44. Wühr M, Haas W, McAlister GC, Peshkin L, Rad R, Kirschner MW, Gygi SP. Accurate multiplexed proteomics at the MS2 level using the complement reporter ion cluster. Anal Chem. 2012 Nov 06; 84(21):9214-21. PMID: 23098179; PMCID: PMC3771681.
  45. Freeman R, Ikuta T, Wu M, Koyanagi R, Kawashima T, Tagawa K, Humphreys T, Fang GC, Fujiyama A, Saiga H, Lowe C, Worley K, Jenkins J, Schmutz J, Kirschner M, Rokhsar D, Satoh N, Gerhart J. Identical genomic organization of two hemichordate hox clusters. Curr Biol. 2012 Nov 06; 22(21):2053-8. PMID: 23063438; PMCID: PMC4524734.
  46. Son S, Tzur A, Weng Y, Jorgensen P, Kim J, Kirschner MW, Manalis SR. Direct observation of mammalian cell growth and size regulation. Nat Methods. 2012 Sep; 9(9):910-2. PMID: 22863882; PMCID: PMC3433595.
  47. Li VC, Ballabeni A, Kirschner MW. Gap 1 phase length and mouse embryonic stem cell self-renewal. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12550-5. PMID: 22802651; PMCID: PMC3412034.
  48. Aminake MN, Mahajan A, Kumar V, Hans R, Wiesner L, Taylor D, de Kock C, Grobler A, Smith PJ, Kirschner M, Rethwilm A, Pradel G, Chibale K. Synthesis and evaluation of hybrid drugs for a potential HIV/AIDS-malaria combination therapy. Bioorg Med Chem. 2012 Sep 01; 20(17):5277-89. PMID: 22858300.
    View in: PubMed
  49. Jain M, Nilsson R, Sharma S, Madhusudhan N, Kitami T, Souza AL, Kafri R, Kirschner MW, Clish CB, Mootha VK. Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation. Science. 2012 May 25; 336(6084):1040-4. PMID: 22628656; PMCID: PMC3526189.
  50. Hao HX, Xie Y, Zhang Y, Charlat O, Oster E, Avello M, Lei H, Mickanin C, Liu D, Ruffner H, Mao X, Ma Q, Zamponi R, Bouwmeester T, Finan PM, Kirschner MW, Porter JA, Serluca FC, Cong F. ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner. Nature. 2012 Apr 29; 485(7397):195-200. PMID: 22575959.
    View in: PubMed
  51. Ballabeni A, Park IH, Zhao R, Wang W, Lerou PH, Daley GQ, Kirschner MW. Cell cycle adaptations of embryonic stem cells. Proc Natl Acad Sci U S A. 2011 Nov 29; 108(48):19252-7. PMID: 22084091; PMCID: PMC3228440.
  52. Ali F, Hindley C, McDowell G, Deibler R, Jones A, Kirschner M, Guillemot F, Philpott A. Cell cycle-regulated multi-site phosphorylation of Neurogenin 2 coordinates cell cycling with differentiation during neurogenesis. Development. 2011 Oct; 138(19):4267-77. PMID: 21852393; PMCID: PMC3171226.
  53. Kirschner MW, Shapiro L, McAdams H, Almouzni G, Sharp PA, Young RA, Alon U. Fifty years after Jacob and Monod: what are the unanswered questions in molecular biology? Mol Cell. 2011 May 20; 42(4):403-4. PMID: 21748867.
    View in: PubMed
  54. Yanai I, Peshkin L, Jorgensen P, Kirschner MW. Mapping gene expression in two Xenopus species: evolutionary constraints and developmental flexibility. Dev Cell. 2011 Apr 19; 20(4):483-96. PMID: 21497761; PMCID: PMC3118554.
  55. Darras S, Gerhart J, Terasaki M, Kirschner M, Lowe CJ. ß-catenin specifies the endomesoderm and defines the posterior organizer of the hemichordate Saccoglossus kowalevskii. Development. 2011 Mar; 138(5):959-70. PMID: 21303849; PMCID: PMC3035098.
  56. Vastag L, Jorgensen P, Peshkin L, Wei R, Rabinowitz JD, Kirschner MW. Remodeling of the metabolome during early frog development. PLoS One. 2011 Feb 04; 6(2):e16881. PMID: 21347444; PMCID: PMC3035664.
  57. Tzur A, Moore JK, Jorgensen P, Shapiro HM, Kirschner MW. Optimizing optical flow cytometry for cell volume-based sorting and analysis. PLoS One. 2011 Jan 20; 6(1):e16053. PMID: 21283800; PMCID: PMC3024321.
  58. Aminake MN, Schoof S, Sologub L, Leubner M, Kirschner M, Arndt HD, Pradel G. Thiostrepton and derivatives exhibit antimalarial and gametocytocidal activity by dually targeting parasite proteasome and apicoplast. Antimicrob Agents Chemother. 2011 Apr; 55(4):1338-48. PMID: 21245445; PMCID: PMC3067198.
  59. Kirschner M. Cell biology as a world view. Mol Biol Cell. 2010 Nov 15; 21(22):3803. PMID: 21079019; PMCID: PMC2982097.
  60. Wu S, Wang W, Kong X, Congdon LM, Yokomori K, Kirschner MW, Rice JC. Dynamic regulation of the PR-Set7 histone methyltransferase is required for normal cell cycle progression. Genes Dev. 2010 Nov 15; 24(22):2531-42. PMID: 20966048; PMCID: PMC2975929.
  61. Merbl Y, Kirschner MW. Protein microarrays for genome-wide posttranslational modification analysis. Wiley Interdiscip Rev Syst Biol Med. 2011 May-Jun; 3(3):347-56. PMID: 20865779.
    View in: PubMed
  62. Lee K, Gallop JL, Rambani K, Kirschner MW. Self-assembly of filopodia-like structures on supported lipid bilayers. Science. 2010 Sep 10; 329(5997):1341-5. PMID: 20829485; PMCID: PMC2982780.
  63. Song EJ, Werner SL, Neubauer J, Stegmeier F, Aspden J, Rio D, Harper JW, Elledge SJ, Kirschner MW, Rape M. The Prp19 complex and the Usp4Sart3 deubiquitinating enzyme control reversible ubiquitination at the spliceosome. Genes Dev. 2010 Jul 01; 24(13):1434-47. PMID: 20595234; PMCID: PMC2895201.
  64. Springer M, Weissman JS, Kirschner MW. A general lack of compensation for gene dosage in yeast. Mol Syst Biol. 2010 May 11; 6:368. PMID: 20461075; PMCID: PMC2890323.
  65. Godin M, Delgado FF, Son S, Grover WH, Bryan AK, Tzur A, Jorgensen P, Payer K, Grossman AD, Kirschner MW, Manalis SR. Using buoyant mass to measure the growth of single cells. Nat Methods. 2010 May; 7(5):387-90. PMID: 20383132; PMCID: PMC2862099.
  66. DeLuna A, Springer M, Kirschner MW, Kishony R. Need-based up-regulation of protein levels in response to deletion of their duplicate genes. PLoS Biol. 2010 Mar 30; 8(3):e1000347. PMID: 20361019; PMCID: PMC2846854.
  67. Deibler RW, Kirschner MW. Quantitative reconstitution of mitotic CDK1 activation in somatic cell extracts. Mol Cell. 2010 Mar 26; 37(6):753-67. PMID: 20347419; PMCID: PMC2882237.
  68. Falkowska-Hansen B, Kollar J, Grüner BM, Schanz M, Boukamp P, Siveke J, Rethwilm A, Kirschner M. An inducible Tet-Off-H2B-GFP lentiviral reporter vector for detection and in vivo isolation of label-retaining cells. Exp Cell Res. 2010 Jul 01; 316(11):1885-95. PMID: 20171964.
    View in: PubMed
  69. Wu T, Merbl Y, Huo Y, Gallop JL, Tzur A, Kirschner MW. UBE2S drives elongation of K11-linked ubiquitin chains by the anaphase-promoting complex. Proc Natl Acad Sci U S A. 2010 Jan 26; 107(4):1355-60. PMID: 20080579; PMCID: PMC2802591.
  70. Goentoro L, Kirschner MW. Evidence that fold-change, and not absolute level, of beta-catenin dictates Wnt signaling. Mol Cell. 2009 Dec 11; 36(5):872-84. PMID: 20005849; PMCID: PMC2921914.
  71. Goentoro L, Shoval O, Kirschner MW, Alon U. The incoherent feedforward loop can provide fold-change detection in gene regulation. Mol Cell. 2009 Dec 11; 36(5):894-9. PMID: 20005851; PMCID: PMC2896310.
  72. Lebensohn AM, Kirschner MW. Activation of the WAVE complex by coincident signals controls actin assembly. Mol Cell. 2009 Nov 13; 36(3):512-24. PMID: 19917258; PMCID: PMC2818508.
  73. Nowotny B, Schneider T, Pradel G, Schirmeister T, Rethwilm A, Kirschner M. Inducible APOBEC3G-Vif double stable cell line as a high-throughput screening platform to identify antiviral compounds. Antimicrob Agents Chemother. 2010 Jan; 54(1):78-87. PMID: 19841153; PMCID: PMC2798503.
  74. Huang SM, Mishina YM, Liu S, Cheung A, Stegmeier F, Michaud GA, Charlat O, Wiellette E, Zhang Y, Wiessner S, Hild M, Shi X, Wilson CJ, Mickanin C, Myer V, Fazal A, Tomlinson R, Serluca F, Shao W, Cheng H, Shultz M, Rau C, Schirle M, Schlegl J, Ghidelli S, Fawell S, Lu C, Curtis D, Kirschner MW, Lengauer C, Finan PM, Tallarico JA, Bouwmeester T, Porter JA, Bauer A, Cong F. Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature. 2009 Oct 01; 461(7264):614-20. PMID: 19759537.
    View in: PubMed
  75. Tzur A, Kafri R, LeBleu VS, Lahav G, Kirschner MW. Cell growth and size homeostasis in proliferating animal cells. Science. 2009 Jul 10; 325(5937):167-71. PMID: 19589995; PMCID: PMC2905160.
  76. Gao D, Inuzuka H, Korenjak M, Tseng A, Wu T, Wan L, Kirschner M, Dyson N, Wei W. Cdh1 regulates cell cycle through modulating the claspin/Chk1 and the Rb/E2F1 pathways. Mol Biol Cell. 2009 Jul; 20(14):3305-16. PMID: 19477924; PMCID: PMC2710831.
  77. Singh S, Springer M, Steen J, Kirschner MW, Steen H. FLEXIQuant: a novel tool for the absolute quantification of proteins, and the simultaneous identification and quantification of potentially modified peptides. J Proteome Res. 2009 May; 8(5):2201-10. PMID: 19344176; PMCID: PMC2868505.
  78. Jorgensen P, Steen JA, Steen H, Kirschner MW. The mechanism and pattern of yolk consumption provide insight into embryonic nutrition in Xenopus. Development. 2009 May; 136(9):1539-48. PMID: 19363155; PMCID: PMC2674260.
  79. Merbl Y, Kirschner MW. Large-scale detection of ubiquitination substrates using cell extracts and protein microarrays. Proc Natl Acad Sci U S A. 2009 Feb 24; 106(8):2543-8. PMID: 19181856; PMCID: PMC2633216.
  80. Freeman RM, Wu M, Cordonnier-Pratt MM, Pratt LH, Gruber CE, Smith M, Lander ES, Stange-Thomann N, Lowe CJ, Gerhart J, Kirschner M. cDNA sequences for transcription factors and signaling proteins of the hemichordate Saccoglossus kowalevskii: efficacy of the expressed sequence tag (EST) approach for evolutionary and developmental studies of a new organism. Biol Bull. 2008 Jun; 214(3):284-302. PMID: 18574105.
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  81. Steen JA, Steen H, Georgi A, Parker K, Springer M, Kirchner M, Hamprecht F, Kirschner MW. Different phosphorylation states of the anaphase promoting complex in response to antimitotic drugs: a quantitative proteomic analysis. Proc Natl Acad Sci U S A. 2008 Apr 22; 105(16):6069-74. PMID: 18420821; PMCID: PMC2329673.
  82. Kirschner M. Profile: Bruce Alberts, Science's new editor. Science. 2008 Feb 29; 319(5867):1199. PMID: 18309070.
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  83. Milo R, Hou JH, Springer M, Brenner MP, Kirschner MW. The relationship between evolutionary and physiological variation in hemoglobin. Proc Natl Acad Sci U S A. 2007 Oct 23; 104(43):16998-7003. PMID: 17942680; PMCID: PMC2040440.
  84. Rickmyre JL, Dasgupta S, Ooi DL, Keel J, Lee E, Kirschner MW, Waddell S, Lee LA. The Drosophila homolog of MCPH1, a human microcephaly gene, is required for genomic stability in the early embryo. J Cell Sci. 2007 Oct 15; 120(Pt 20):3565-77. PMID: 17895362.
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  85. Weiner OD, Marganski WA, Wu LF, Altschuler SJ, Kirschner MW. An actin-based wave generator organizes cell motility. PLoS Biol. 2007 Sep; 5(9):e221. PMID: 17696648; PMCID: PMC1945041.
  86. Gerhart J, Kirschner M. The theory of facilitated variation. Proc Natl Acad Sci U S A. 2007 May 15; 104 Suppl 1:8582-9. PMID: 17494755; PMCID: PMC1876433.
  87. Reddy SK, Rape M, Margansky WA, Kirschner MW. Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation. Nature. 2007 Apr 19; 446(7138):921-5. PMID: 17443186.
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  88. Stegmeier F, Rape M, Draviam VM, Nalepa G, Sowa ME, Ang XL, McDonald ER, Li MZ, Hannon GJ, Sorger PK, Kirschner MW, Harper JW, Elledge SJ. Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities. Nature. 2007 Apr 19; 446(7138):876-81. PMID: 17443180.
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  89. Wang R, He G, Nelman-Gonzalez M, Ashorn CL, Gallick GE, Stukenberg PT, Kirschner MW, Kuang J. Regulation of Cdc25C by ERK-MAP kinases during the G2/M transition. Cell. 2007 Mar 23; 128(6):1119-32. PMID: 17382881.
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  90. Kirschner MW. Obituary: Reinhart Heinrich (1946-2006). Nature. 2006 Dec 07; 444(7120):700. PMID: 17151654.
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  91. Lowe CJ, Terasaki M, Wu M, Freeman RM, Runft L, Kwan K, Haigo S, Aronowicz J, Lander E, Gruber C, Smith M, Kirschner M, Gerhart J. Dorsoventral patterning in hemichordates: insights into early chordate evolution. PLoS Biol. 2006 Sep; 4(9):e291. PMID: 16933975; PMCID: PMC1551926.
  92. Peterson JR, Lebensohn AM, Pelish HE, Kirschner MW. Biochemical suppression of small-molecule inhibitors: a strategy to identify inhibitor targets and signaling pathway components. Chem Biol. 2006 Apr; 13(4):443-52. PMID: 16632257; PMCID: PMC1820768.
  93. Weiner OD, Rentel MC, Ott A, Brown GE, Jedrychowski M, Yaffe MB, Gygi SP, Cantley LC, Bourne HR, Kirschner MW. Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis. PLoS Biol. 2006 Feb; 4(2):e38. PMID: 16417406; PMCID: PMC1334198.
  94. Rape M, Reddy SK, Kirschner MW. The processivity of multiubiquitination by the APC determines the order of substrate degradation. Cell. 2006 Jan 13; 124(1):89-103. PMID: 16413484.
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  95. Lebensohn AM, Ma L, Ho HY, Kirschner MW. Cdc42 and PI(4,5)P2-induced actin assembly in Xenopus egg extracts. Methods Enzymol. 2006; 406:156-73. PMID: 16472657.
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  96. Ho HY, Rohatgi R, Lebensohn AM, Kirschner MW. In vitro reconstitution of cdc42-mediated actin assembly using purified components. Methods Enzymol. 2006; 406:174-90. PMID: 16472658.
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  97. Jebanathirajah JA, Pittman JL, Thomson BA, Budnik BA, Kaur P, Rape M, Kirschner M, Costello CE, O'Connor PB. Characterization of a new qQq-FTICR mass spectrometer for post-translational modification analysis and top-down tandem mass spectrometry of whole proteins. J Am Soc Mass Spectrom. 2005 Dec; 16(12):1985-99. PMID: 16271296.
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  98. Steen H, Jebanathirajah JA, Rush J, Morrice N, Kirschner MW. Phosphorylation analysis by mass spectrometry: myths, facts, and the consequences for qualitative and quantitative measurements. Mol Cell Proteomics. 2006 Jan; 5(1):172-81. PMID: 16204703.
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  99. Kwan KM, Kirschner MW. A microtubule-binding Rho-GEF controls cell morphology during convergent extension of Xenopus laevis. Development. 2005 Oct; 132(20):4599-610. PMID: 16176947; PMCID: PMC1783841.
  100. Gerhart J, Lowe C, Kirschner M. Hemichordates and the origin of chordates. Curr Opin Genet Dev. 2005 Aug; 15(4):461-7. PMID: 15964754.
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  101. Beddows S, Schülke N, Kirschner M, Barnes K, Franti M, Michael E, Ketas T, Sanders RW, Maddon PJ, Olson WC, Moore JP. Evaluating the immunogenicity of a disulfide-stabilized, cleaved, trimeric form of the envelope glycoprotein complex of human immunodeficiency virus type 1. J Virol. 2005 Jul; 79(14):8812-27. PMID: 15994775; PMCID: PMC1168742.
  102. Kirschner MW. The meaning of systems biology. Cell. 2005 May 20; 121(4):503-4. PMID: 15907462.
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  103. Viadiu H, Stemmann O, Kirschner MW, Walz T. Domain structure of separase and its binding to securin as determined by EM. Nat Struct Mol Biol. 2005 Jun; 12(6):552-3. PMID: 15880121.
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  104. Rankin S, Ayad NG, Kirschner MW. Sororin, a substrate of the anaphase-promoting complex, is required for sister chromatid cohesion in vertebrates. Mol Cell. 2005 Apr 15; 18(2):185-200. PMID: 15837422.
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  105. Steen H, Jebanathirajah JA, Springer M, Kirschner MW. Stable isotope-free relative and absolute quantitation of protein phosphorylation stoichiometry by MS. Proc Natl Acad Sci U S A. 2005 Mar 15; 102(11):3948-53. PMID: 15741271; PMCID: PMC552780.
  106. Lee LA, Lee E, Anderson MA, Vardy L, Tahinci E, Ali SM, Kashevsky H, Benasutti M, Kirschner MW, Orr-Weaver TL. Drosophila genome-scale screen for PAN GU kinase substrates identifies Mat89Bb as a cell cycle regulator. Dev Cell. 2005 Mar; 8(3):435-42. PMID: 15737938.
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  107. Ayad NG, Rankin S, Ooi D, Rape M, Kirschner MW. Identification of ubiquitin ligase substrates by in vitro expression cloning. Methods Enzymol. 2005; 399:404-14. PMID: 16338372.
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  108. Rape M, Kirschner MW. Autonomous regulation of the anaphase-promoting complex couples mitosis to S-phase entry. Nature. 2004 Dec 02; 432(7017):588-95. PMID: 15558010.
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  109. Margalit DN, Romberg L, Mets RB, Hebert AM, Mitchison TJ, Kirschner MW, RayChaudhuri D. Targeting cell division: small-molecule inhibitors of FtsZ GTPase perturb cytokinetic ring assembly and induce bacterial lethality. Proc Natl Acad Sci U S A. 2004 Aug 10; 101(32):11821-6. PMID: 15289600; PMCID: PMC511058.
  110. Ho HY, Rohatgi R, Lebensohn AM, Li J, Gygi SP, Kirschner MW. Toca-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex. Cell. 2004 Jul 23; 118(2):203-16. PMID: 15260990.
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  111. Peterson JR, Bickford LC, Morgan D, Kim AS, Ouerfelli O, Kirschner MW, Rosen MK. Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation. Nat Struct Mol Biol. 2004 Aug; 11(8):747-55. PMID: 15235593.
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  112. Martinez-Quiles N, Ho HY, Kirschner MW, Ramesh N, Geha RS. Erk/Src phosphorylation of cortactin acts as a switch on-switch off mechanism that controls its ability to activate N-WASP. Mol Cell Biol. 2004 Jun; 24(12):5269-80. PMID: 15169891; PMCID: PMC419870.
  113. Gautreau A, Ho HY, Li J, Steen H, Gygi SP, Kirschner MW. Purification and architecture of the ubiquitous Wave complex. Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13):4379-83. PMID: 15070726; PMCID: PMC384755.
  114. Wei W, Ayad NG, Wan Y, Zhang GJ, Kirschner MW, Kaelin WG. Degradation of the SCF component Skp2 in cell-cycle phase G1 by the anaphase-promoting complex. Nature. 2004 Mar 11; 428(6979):194-8. PMID: 15014503.
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  115. Campellone KG, Rankin S, Pawson T, Kirschner MW, Tipper DJ, Leong JM. Clustering of Nck by a 12-residue Tir phosphopeptide is sufficient to trigger localized actin assembly. J Cell Biol. 2004 Feb 02; 164(3):407-16. PMID: 14757753; PMCID: PMC2172230.
  116. Song MS, Song SJ, Ayad NG, Chang JS, Lee JH, Hong HK, Lee H, Choi N, Kim J, Kim H, Kim JW, Choi EJ, Kirschner MW, Lim DS. The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC-Cdc20 complex. Nat Cell Biol. 2004 Feb; 6(2):129-37. PMID: 14743218.
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  117. Lowe CJ, Tagawa K, Humphreys T, Kirschner M, Gerhart J. Hemichordate embryos: procurement, culture, and basic methods. Methods Cell Biol. 2004; 74:171-94. PMID: 15575607.
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  118. Lee E, Salic A, Krüger R, Heinrich R, Kirschner MW. The roles of APC and Axin derived from experimental and theoretical analysis of the Wnt pathway. PLoS Biol. 2003 Oct; 1(1):E10. PMID: 14551908; PMCID: PMC212691.
  119. Yan C, Martinez-Quiles N, Eden S, Shibata T, Takeshima F, Shinkura R, Fujiwara Y, Bronson R, Snapper SB, Kirschner MW, Geha R, Rosen FS, Alt FW. WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motility. EMBO J. 2003 Jul 15; 22(14):3602-12. PMID: 12853475; PMCID: PMC165620.
  120. Lowe CJ, Wu M, Salic A, Evans L, Lander E, Stange-Thomann N, Gruber CE, Gerhart J, Kirschner M. Anteroposterior patterning in hemichordates and the origins of the chordate nervous system. Cell. 2003 Jun 27; 113(7):853-65. PMID: 12837244.
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  121. Gerber SA, Rush J, Stemman O, Kirschner MW, Gygi SP. Absolute quantification of proteins and phosphoproteins from cell lysates by tandem MS. Proc Natl Acad Sci U S A. 2003 Jun 10; 100(12):6940-5. PMID: 12771378; PMCID: PMC165809.
  122. Osterfield M, Kirschner MW, Flanagan JG. Graded positional information: interpretation for both fate and guidance. Cell. 2003 May 16; 113(4):425-8. PMID: 12757702.
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  123. Kwan KM, Kirschner MW. Xbra functions as a switch between cell migration and convergent extension in the Xenopus gastrula. Development. 2003 May; 130(9):1961-72. PMID: 12642499.
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  124. Ayad NG, Rankin S, Murakami M, Jebanathirajah J, Gygi S, Kirschner MW. Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC. Cell. 2003 Apr 04; 113(1):101-13. PMID: 12679038.
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  125. Chabes AL, Pfleger CM, Kirschner MW, Thelander L. Mouse ribonucleotide reductase R2 protein: a new target for anaphase-promoting complex-Cdh1-mediated proteolysis. Proc Natl Acad Sci U S A. 2003 Apr 01; 100(7):3925-9. PMID: 12655059; PMCID: PMC153024.
  126. Collavin L, Kirschner MW. The secreted Frizzled-related protein Sizzled functions as a negative feedback regulator of extreme ventral mesoderm. Development. 2003 Feb; 130(4):805-16. PMID: 12506010.
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  127. Kirschner M, Pujol G, Radu A. Oligonucleotide microarray data mining: search for age-dependent gene expression. Biochem Biophys Res Commun. 2002 Nov 15; 298(5):772-8. PMID: 12419321.
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  128. Zhu Z, Kirschner M. Regulated proteolysis of Xom mediates dorsoventral pattern formation during early Xenopus development. Dev Cell. 2002 Oct; 3(4):557-68. PMID: 12408807.
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  129. Zou H, Stemman O, Anderson JS, Mann M, Kirschner MW. Anaphase specific auto-cleavage of separase. FEBS Lett. 2002 Sep 25; 528(1-3):246-50. PMID: 12297314.
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  130. Castiglione F, Bernaschi M, Succi S, Heinrich R, Kirschner MW. Intracellular signal propagation in a two-dimensional autocatalytic reaction model. Phys Rev E Stat Nonlin Soft Matter Phys. 2002 Sep; 66(3 Pt 1):031905. PMID: 12366150.
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  131. Eden S, Rohatgi R, Podtelejnikov AV, Mann M, Kirschner MW. Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck. Nature. 2002 Aug 15; 418(6899):790-3. PMID: 12181570.
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  132. Holmen SL, Salic A, Zylstra CR, Kirschner MW, Williams BO. A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta -catenin-dependent signaling. J Biol Chem. 2002 Sep 20; 277(38):34727-35. PMID: 12121999.
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  133. Farhana L, Dawson M, Rishi AK, Zhang Y, Van Buren E, Trivedi C, Reichert U, Fang G, Kirschner MW, Fontana JA. Cyclin B and E2F-1 expression in prostate carcinoma cells treated with the novel retinoid CD437 are regulated by the ubiquitin-mediated pathway. Cancer Res. 2002 Jul 01; 62(13):3842-9. PMID: 12097298.
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  134. Weiner OD, Neilsen PO, Prestwich GD, Kirschner MW, Cantley LC, Bourne HR. A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity. Nat Cell Biol. 2002 Jul; 4(7):509-13. PMID: 12080346; PMCID: PMC2823287.
  135. Morpurgo M, Kirschner M, Radu A. An approach to increased polyplex gene delivery by peptides selected from a phage display library. J Biochem Biophys Methods. 2002 Jun 28; 52(1):31-43. PMID: 12121752.
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  136. Georgi AB, Stukenberg PT, Kirschner MW. Timing of events in mitosis. Curr Biol. 2002 Jan 22; 12(2):105-14. PMID: 11818060.
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  137. Stemmann O, Zou H, Gerber SA, Gygi SP, Kirschner MW. Dual inhibition of sister chromatid separation at metaphase. Cell. 2001 Dec 14; 107(6):715-26. PMID: 11747808.
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  138. Wan Y, Liu X, Kirschner MW. The anaphase-promoting complex mediates TGF-beta signaling by targeting SnoN for destruction. Mol Cell. 2001 Nov; 8(5):1027-39. PMID: 11741538.
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  139. Wan Y, Kirschner MW. Identification of multiple CDH1 homologues in vertebrates conferring different substrate specificities. Proc Natl Acad Sci U S A. 2001 Nov 06; 98(23):13066-71. PMID: 11687641; PMCID: PMC60825.
  140. Davis RL, Turner DL, Evans LM, Kirschner MW. Molecular targets of vertebrate segmentation: two mechanisms control segmental expression of Xenopus hairy2 during somite formation. Dev Cell. 2001 Oct; 1(4):553-65. PMID: 11703945.
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  141. Pfleger CM, Lee E, Kirschner MW. Substrate recognition by the Cdc20 and Cdh1 components of the anaphase-promoting complex. Genes Dev. 2001 Sep 15; 15(18):2396-407. PMID: 11562349; PMCID: PMC312782.
  142. Peterson JR, Lokey RS, Mitchison TJ, Kirschner MW. A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions. Proc Natl Acad Sci U S A. 2001 Sep 11; 98(19):10624-9. PMID: 11553809; PMCID: PMC58516.
  143. Ho HY, Rohatgi R, Ma L, Kirschner MW. CR16 forms a complex with N-WASP in brain and is a novel member of a conserved proline-rich actin-binding protein family. Proc Natl Acad Sci U S A. 2001 Sep 25; 98(20):11306-11. PMID: 11553796; PMCID: PMC58725.
  144. Lee E, Salic A, Kirschner MW. Physiological regulation of [beta]-catenin stability by Tcf3 and CK1epsilon. J Cell Biol. 2001 Sep 03; 154(5):983-93. PMID: 11524435; PMCID: PMC2196183.
  145. Pfleger CM, Salic A, Lee E, Kirschner MW. Inhibition of Cdh1-APC by the MAD2-related protein MAD2L2: a novel mechanism for regulating Cdh1. Genes Dev. 2001 Jul 15; 15(14):1759-64. PMID: 11459825; PMCID: PMC312740.
  146. Rohatgi R, Nollau P, Ho HY, Kirschner MW, Mayer BJ. Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway. J Biol Chem. 2001 Jul 13; 276(28):26448-52. PMID: 11340081.
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  147. Stukenberg PT, Kirschner MW. Pin1 acts catalytically to promote a conformational change in Cdc25. Mol Cell. 2001 May; 7(5):1071-83. PMID: 11389853.
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  148. Roberts RJ, Varmus HE, Ashburner M, Brown PO, Eisen MB, Khosla C, Kirschner M, Nusse R, Scott M, Wold B. Information access. Building a "GenBank" of the published literature. Science. 2001 Mar 23; 291(5512):2318-9. PMID: 11269300.
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  149. Feng Y, Olson EC, Stukenberg PT, Flanagan LA, Kirschner MW, Walsh CA. LIS1 regulates CNS lamination by interacting with mNudE, a central component of the centrosome. Neuron. 2000 Dec; 28(3):665-79. PMID: 11163258.
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  150. Yamaguchi H, Miki H, Suetsugu S, Ma L, Kirschner MW, Takenawa T. Two tandem verprolin homology domains are necessary for a strong activation of Arp2/3 complex-induced actin polymerization and induction of microspike formation by N-WASP. Proc Natl Acad Sci U S A. 2000 Nov 07; 97(23):12631-6. PMID: 11058146; PMCID: PMC18815.
  151. Kirschner M, Winkelhaus S, Thierfelder JM, Nover L. Transient expression and heat-stress-induced co-aggregation of endogenous and heterologous small heat-stress proteins in tobacco protoplasts. Plant J. 2000 Nov; 24(3):397-411. PMID: 11069712.
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  152. Rohatgi R, Ho HY, Kirschner MW. Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphate. J Cell Biol. 2000 Sep 18; 150(6):1299-310. PMID: 10995436; PMCID: PMC2150699.
  153. Chen F, Ma L, Parrini MC, Mao X, Lopez M, Wu C, Marks PW, Davidson L, Kwiatkowski DJ, Kirchhausen T, Orkin SH, Rosen FS, Mayer BJ, Kirschner MW, Alt FW. Cdc42 is required for PIP(2)-induced actin polymerization and early development but not for cell viability. Curr Biol. 2000 Jun 29; 10(13):758-65. PMID: 10898977.
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  154. Pfleger CM, Kirschner MW. The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1. Genes Dev. 2000 Mar 15; 14(6):655-65. PMID: 10733526; PMCID: PMC316466.
  155. Salic A, Lee E, Mayer L, Kirschner MW. Control of beta-catenin stability: reconstitution of the cytoplasmic steps of the wnt pathway in Xenopus egg extracts. Mol Cell. 2000 Mar; 5(3):523-32. PMID: 10882137.
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  156. Luo X, Fang G, Coldiron M, Lin Y, Yu H, Kirschner MW, Wagner G. Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20. Nat Struct Biol. 2000 Mar; 7(3):224-9. PMID: 10700282.
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  157. Kirschner M, Gerhart J, Mitchison T. Molecular "vitalism". Cell. 2000 Jan 07; 100(1):79-88. PMID: 10647933.
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  158. Davis RL, Kirschner MW. The fate of cells in the tailbud of Xenopus laevis. Development. 2000 Jan; 127(2):255-67. PMID: 10603344.
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  159. Kroll KL, Kirschner MW. Easy passage: germline transgenesis in frogs. Proc Natl Acad Sci U S A. 1999 Dec 07; 96(25):14189-90. PMID: 10588674; PMCID: PMC33941.
  160. Kirschner M. Intracellular proteolysis. Trends Cell Biol. 1999 Dec; 9(12):M42-5. PMID: 10611680.
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  161. Odde DJ, Ma L, Briggs AH, DeMarco A, Kirschner MW. Microtubule bending and breaking in living fibroblast cells. J Cell Sci. 1999 Oct; 112 ( Pt 19):3283-8. PMID: 10504333.
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  162. Fang G, Yu H, Kirschner MW. Control of mitotic transitions by the anaphase-promoting complex. Philos Trans R Soc Lond B Biol Sci. 1999 Sep 29; 354(1389):1583-90. PMID: 10582244; PMCID: PMC1692672.
  163. Zou H, McGarry TJ, Bernal T, Kirschner MW. Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis. Science. 1999 Jul 16; 285(5426):418-22. PMID: 10411507.
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  164. Rohatgi R, Ma L, Miki H, Lopez M, Kirchhausen T, Takenawa T, Kirschner MW. The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly. Cell. 1999 Apr 16; 97(2):221-31. PMID: 10219243.
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  165. Philpott A, Tsai L, Kirschner MW. Neuronal differentiation and patterning in Xenopus: the role of cdk5 and a novel activator xp35.2. Dev Biol. 1999 Mar 01; 207(1):119-32. PMID: 10049569.
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  166. Haushalter KA, Todd Stukenberg MW, Kirschner MW, Verdine GL. Identification of a new uracil-DNA glycosylase family by expression cloning using synthetic inhibitors. Curr Biol. 1999 Feb 25; 9(4):174-85. PMID: 10074426.
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  167. Kirschner M. A visit to the Hubrecht laboratory. Int J Dev Biol. 1999; 43(7):629-31. PMID: 10668973.
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  168. Zhou BB, Kirschner MW. Quantitative measurement of the catastrophe rate of dynamic microtubules. Cell Motil Cytoskeleton. 1999; 43(1):43-51. PMID: 10340702.
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  169. Ma L, Rohatgi R, Kirschner MW. The Arp2/3 complex mediates actin polymerization induced by the small GTP-binding protein Cdc42. Proc Natl Acad Sci U S A. 1998 Dec 22; 95(26):15362-7. PMID: 9860974; PMCID: PMC28048.
  170. Sif S, Stukenberg PT, Kirschner MW, Kingston RE. Mitotic inactivation of a human SWI/SNF chromatin remodeling complex. Genes Dev. 1998 Sep 15; 12(18):2842-51. PMID: 9744861; PMCID: PMC317164.
  171. Mead PE, Zhou Y, Lustig KD, Huber TL, Kirschner MW, Zon LI. Cloning of Mix-related homeodomain proteins using fast retrieval of gel shift activities, (FROGS), a technique for the isolation of DNA-binding proteins. Proc Natl Acad Sci U S A. 1998 Sep 15; 95(19):11251-6. PMID: 9736722; PMCID: PMC21628.
  172. Fang G, Yu H, Kirschner MW. Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1. Mol Cell. 1998 Aug; 2(2):163-71. PMID: 9734353.
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  173. Kroll KL, Salic AN, Evans LM, Kirschner MW. Geminin, a neuralizing molecule that demarcates the future neural plate at the onset of gastrulation. Development. 1998 Aug; 125(16):3247-58. PMID: 9671596.
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  174. Kirschner M, Gerhart J. Evolvability. Proc Natl Acad Sci U S A. 1998 Jul 21; 95(15):8420-7. PMID: 9671692; PMCID: PMC33871.
  175. Fang G, Yu H, Kirschner MW. The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation. Genes Dev. 1998 Jun 15; 12(12):1871-83. PMID: 9637688; PMCID: PMC316912.
  176. McGarry TJ, Kirschner MW. Geminin, an inhibitor of DNA replication, is degraded during mitosis. Cell. 1998 Jun 12; 93(6):1043-53. PMID: 9635433.
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  177. Zhou BB, Li H, Yuan J, Kirschner MW. Caspase-dependent activation of cyclin-dependent kinases during Fas-induced apoptosis in Jurkat cells. Proc Natl Acad Sci U S A. 1998 Jun 09; 95(12):6785-90. PMID: 9618490; PMCID: PMC22635.
  178. Ma L, Cantley LC, Janmey PA, Kirschner MW. Corequirement of specific phosphoinositides and small GTP-binding protein Cdc42 in inducing actin assembly in Xenopus egg extracts. J Cell Biol. 1998 Mar 09; 140(5):1125-36. PMID: 9490725; PMCID: PMC2132704.
  179. Shen M, Stukenberg PT, Kirschner MW, Lu KP. The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins. Genes Dev. 1998 Mar 01; 12(5):706-20. PMID: 9499405; PMCID: PMC316589.
  180. Yu H, Peters JM, King RW, Page AM, Hieter P, Kirschner MW. Identification of a cullin homology region in a subunit of the anaphase-promoting complex. Science. 1998 Feb 20; 279(5354):1219-22. PMID: 9469815.
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  181. Yaffe MB, Schutkowski M, Shen M, Zhou XZ, Stukenberg PT, Rahfeld JU, Xu J, Kuang J, Kirschner MW, Fischer G, Cantley LC, Lu KP. Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism. Science. 1997 Dec 12; 278(5345):1957-60. PMID: 9395400.
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  182. Salic AN, Kroll KL, Evans LM, Kirschner MW. Sizzled: a secreted Xwnt8 antagonist expressed in the ventral marginal zone of Xenopus embryos. Development. 1997 Dec; 124(23):4739-48. PMID: 9428410.
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  185. Yew PR, Kirschner MW. Proteolysis and DNA replication: the CDC34 requirement in the Xenopus egg cell cycle. Science. 1997 Sep 12; 277(5332):1672-6. PMID: 9287222.
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  187. Philpott A, Porro EB, Kirschner MW, Tsai LH. The role of cyclin-dependent kinase 5 and a novel regulatory subunit in regulating muscle differentiation and patterning. Genes Dev. 1997 Jun 01; 11(11):1409-21. PMID: 9192869.
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  190. Barondes SH, Alberts BM, Andreasen NC, Bargmann C, Benes F, Goldman-Rakic P, Gottesman I, Heinemann SF, Jones EG, Kirschner M, Lewis D, Raff M, Roses A, Rubenstein J, Snyder S, Watson SJ, Weinberger DR, Yolken RH. Workshop on schizophrenia. Proc Natl Acad Sci U S A. 1997 Mar 04; 94(5):1612-4. PMID: 9050825; PMCID: PMC34140.
  191. Yamashita YM, Peters JM, King RW, Höög C, Kirschner MW, Zachariae W, Shin TH, Galova M, Obermaier B, Nasmyth K. BIME joins the destruction team. Trends Cell Biol. 1997 Feb; 7(2):49. PMID: 17708905.
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  193. Cohen-Fix O, Peters JM, Kirschner MW, Koshland D. Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p. Genes Dev. 1996 Dec 15; 10(24):3081-93. PMID: 8985178.
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  194. King RW, Deshaies RJ, Peters JM, Kirschner MW. How proteolysis drives the cell cycle. Science. 1996 Dec 06; 274(5293):1652-9. PMID: 8939846.
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  195. Lustig KD, Kroll KL, Sun EE, Kirschner MW. Expression cloning of a Xenopus T-related gene (Xombi) involved in mesodermal patterning and blastopore lip formation. Development. 1996 Dec; 122(12):4001-12. PMID: 9012520.
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  197. Lustig KD, Kroll K, Sun E, Ramos R, Elmendorf H, Kirschner MW. A Xenopus nodal-related gene that acts in synergy with noggin to induce complete secondary axis and notochord formation. Development. 1996 Oct; 122(10):3275-82. PMID: 8898239.
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  198. King RW, Glotzer M, Kirschner MW. Mutagenic analysis of the destruction signal of mitotic cyclins and structural characterization of ubiquitinated intermediates. Mol Biol Cell. 1996 Sep; 7(9):1343-57. PMID: 8885231; PMCID: PMC275986.
  199. Yu H, King RW, Peters JM, Kirschner MW. Identification of a novel ubiquitin-conjugating enzyme involved in mitotic cyclin degradation. Curr Biol. 1996 Apr 01; 6(4):455-66. PMID: 8723350.
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  200. Lee TH, Kirschner MW. An inhibitor of p34cdc2/cyclin B that regulates the G2/M transition in Xenopus extracts. Proc Natl Acad Sci U S A. 1996 Jan 09; 93(1):352-6. PMID: 8552637; PMCID: PMC40236.
  201. Kinoshita N, Minshull J, Kirschner MW. The identification of two novel ligands of the FGF receptor by a yeast screening method and their activity in Xenopus development. Cell. 1995 Nov 17; 83(4):621-30. PMID: 7585965.
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  202. Jackson PK, Chevalier S, Philippe M, Kirschner MW. Early events in DNA replication require cyclin E and are blocked by p21CIP1. J Cell Biol. 1995 Aug; 130(4):755-69. PMID: 7642695; PMCID: PMC2199964.
  203. Lustig KD, Kirschner MW. Use of an oocyte expression assay to reconstitute inductive signaling. Proc Natl Acad Sci U S A. 1995 Jul 03; 92(14):6234-8. PMID: 7541533; PMCID: PMC41492.
  204. Kirschner M. In memory of harold weintraub. Mol Biol Cell. 1995 Jul; 6(7):757-8. PMID: 16562164.
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  205. Sabry J, O'Connor TP, Kirschner MW. Axonal transport of tubulin in Ti1 pioneer neurons in situ. Neuron. 1995 Jun; 14(6):1247-56. PMID: 7541635.
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  206. Brändli AW, Kirschner MW. Molecular cloning of tyrosine kinases in the early Xenopus embryo: identification of Eck-related genes expressed in cranial neural crest cells of the second (hyoid) arch. Dev Dyn. 1995 Jun; 203(2):119-40. PMID: 7655077.
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  207. King RW, Peters JM, Tugendreich S, Rolfe M, Hieter P, Kirschner MW. A 20S complex containing CDC27 and CDC16 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B. Cell. 1995 Apr 21; 81(2):279-88. PMID: 7736580.
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  208. Chen J, Jackson PK, Kirschner MW, Dutta A. Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA. Nature. 1995 Mar 23; 374(6520):386-8. PMID: 7885482.
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  209. Deshaies RJ, Kirschner M. G1 cyclin-dependent activation of p34CDC28 (Cdc28p) in vitro. Proc Natl Acad Sci U S A. 1995 Feb 14; 92(4):1182-6. PMID: 7862657; PMCID: PMC42662.
  210. Deshaies RJ, Chau V, Kirschner M. Ubiquitination of the G1 cyclin Cln2p by a Cdc34p-dependent pathway. EMBO J. 1995 Jan 16; 14(2):303-12. PMID: 7835341; PMCID: PMC398084.
  211. Tanaka E, Kirschner MW. The role of microtubules in growth cone turning at substrate boundaries. J Cell Biol. 1995 Jan; 128(1-2):127-37. PMID: 7822410; PMCID: PMC2120338.
  212. Tanaka E, Ho T, Kirschner MW. The role of microtubule dynamics in growth cone motility and axonal growth. J Cell Biol. 1995 Jan; 128(1-2):139-55. PMID: 7822411; PMCID: PMC2120332.
  213. Drechsel DN, Kirschner MW. The minimum GTP cap required to stabilize microtubules. Curr Biol. 1994 Dec 01; 4(12):1053-61. PMID: 7704569.
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  214. King RW, Jackson PK, Kirschner MW. Mitosis in transition. Cell. 1994 Nov 18; 79(4):563-71. PMID: 7954823.
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  217. Doxsey SJ, Stein P, Evans L, Calarco PD, Kirschner M. Pericentrin, a highly conserved centrosome protein involved in microtubule organization. Cell. 1994 Feb 25; 76(4):639-50. PMID: 8124707.
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  218. Stearns T, Kirschner M. In vitro reconstitution of centrosome assembly and function: the central role of gamma-tubulin. Cell. 1994 Feb 25; 76(4):623-37. PMID: 8124706.
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  219. Booher RN, Deshaies RJ, Kirschner MW. Properties of Saccharomyces cerevisiae wee1 and its differential regulation of p34CDC28 in response to G1 and G2 cyclins. EMBO J. 1993 Sep; 12(9):3417-26. PMID: 8253069; PMCID: PMC413617.
  220. Amaya E, Stein PA, Musci TJ, Kirschner MW. FGF signalling in the early specification of mesoderm in Xenopus. Development. 1993 Jun; 118(2):477-87. PMID: 8223274.
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  221. Bishop JM, Kirschner M, Varmus H. Science and the new administration. Science. 1993 Jan 22; 259(5094):444-5. PMID: 8424162.
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  222. Drechsel DN, Hyman AA, Cobb MH, Kirschner MW. Modulation of the dynamic instability of tubulin assembly by the microtubule-associated protein tau. Mol Biol Cell. 1992 Oct; 3(10):1141-54. PMID: 1421571; PMCID: PMC275678.
  223. Kirschner M. The cell cycle then and now. Trends Biochem Sci. 1992 Aug; 17(8):281-5. PMID: 1412700.
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  225. Kirschner MW. The biochemical nature of the cell cycle. Important Adv Oncol. 1992; 3-16. PMID: 1533849.
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  226. Butner KA, Kirschner MW. Tau protein binds to microtubules through a flexible array of distributed weak sites. J Cell Biol. 1991 Nov; 115(3):717-30. PMID: 1918161; PMCID: PMC2289193.
  227. Gautier J, Solomon MJ, Booher RN, Bazan JF, Kirschner MW. cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2. Cell. 1991 Oct 04; 67(1):197-211. PMID: 1913817.
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  228. Kirschner M. The need for unity in the biomedical research community. Acad Med. 1991 Oct; 66(10):577-82. PMID: 1910389.
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  229. Tanaka EM, Kirschner MW. Microtubule behavior in the growth cones of living neurons during axon elongation. J Cell Biol. 1991 Oct; 115(2):345-63. PMID: 1918145; PMCID: PMC2289161.
  230. Reinsch SS, Mitchison TJ, Kirschner M. Microtubule polymer assembly and transport during axonal elongation. J Cell Biol. 1991 Oct; 115(2):365-79. PMID: 1717484; PMCID: PMC2289149.
  231. Sabry JH, O'Connor TP, Evans L, Toroian-Raymond A, Kirschner M, Bentley D. Microtubule behavior during guidance of pioneer neuron growth cones in situ. J Cell Biol. 1991 Oct; 115(2):381-95. PMID: 1918146; PMCID: PMC2289145.
  232. Amaya E, Musci TJ, Kirschner MW. Expression of a dominant negative mutant of the FGF receptor disrupts mesoderm formation in Xenopus embryos. Cell. 1991 Jul 26; 66(2):257-70. PMID: 1649700.
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  233. Stearns T, Evans L, Kirschner M. Gamma-tubulin is a highly conserved component of the centrosome. Cell. 1991 May 31; 65(5):825-36. PMID: 1840506.
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  234. Lundgren K, Walworth N, Booher R, Dembski M, Kirschner M, Beach D. mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2. Cell. 1991 Mar 22; 64(6):1111-22. PMID: 1706223.
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  235. Murray AW, Kirschner MW. What controls the cell cycle? Sci Am. 1991 Mar; 264(3):56-63. PMID: 1828616.
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  236. Lee TH, Solomon MJ, Mumby MC, Kirschner MW. INH, a negative regulator of MPF, is a form of protein phosphatase 2A. Cell. 1991 Jan 25; 64(2):415-23. PMID: 1846321.
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  237. Glotzer M, Murray AW, Kirschner MW. Cyclin is degraded by the ubiquitin pathway. Nature. 1991 Jan 10; 349(6305):132-8. PMID: 1846030.
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  238. Solomon MJ, Gautier J, Lee T, Kirschner MW. Control of p34cdc2 activation. Cold Spring Harb Symp Quant Biol. 1991; 56:427-35. PMID: 1840256.
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  239. Solomon MJ, Glotzer M, Lee TH, Philippe M, Kirschner MW. Cyclin activation of p34cdc2. Cell. 1990 Nov 30; 63(5):1013-24. PMID: 2147872.
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  240. Steiner B, Mandelkow EM, Biernat J, Gustke N, Meyer HE, Schmidt B, Mieskes G, Söling HD, Drechsel D, Kirschner MW, et al. Phosphorylation of microtubule-associated protein tau: identification of the site for Ca2(+)-calmodulin dependent kinase and relationship with tau phosphorylation in Alzheimer tangles. EMBO J. 1990 Nov; 9(11):3539-44. PMID: 2120043; PMCID: PMC552103.
  241. Musci TJ, Amaya E, Kirschner MW. Regulation of the fibroblast growth factor receptor in early Xenopus embryos. Proc Natl Acad Sci U S A. 1990 Nov; 87(21):8365-9. PMID: 2172985; PMCID: PMC54956.
  242. Ward GE, Kirschner MW. Identification of cell cycle-regulated phosphorylation sites on nuclear lamin C. Cell. 1990 May 18; 61(4):561-77. PMID: 2188730.
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  243. Kimelman D, Kirschner MW. An antisense mRNA directs the covalent modification of the transcript encoding fibroblast growth factor in Xenopus oocytes. Cell. 1989 Nov 17; 59(4):687-96. PMID: 2479482.
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  244. Murray AW, Kirschner MW. Dominoes and clocks: the union of two views of the cell cycle. Science. 1989 Nov 03; 246(4930):614-21. PMID: 2683077.
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  245. Murray AW, Solomon MJ, Kirschner MW. The role of cyclin synthesis and degradation in the control of maturation promoting factor activity. Nature. 1989 May 25; 339(6222):280-6. PMID: 2566918.
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  246. Murray AW, Kirschner MW. Cyclin synthesis drives the early embryonic cell cycle. Nature. 1989 May 25; 339(6222):275-80. PMID: 2566917.
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  247. Himmler A, Drechsel D, Kirschner MW, Martin DW. Tau consists of a set of proteins with repeated C-terminal microtubule-binding domains and variable N-terminal domains. Mol Cell Biol. 1989 Apr; 9(4):1381-8. PMID: 2498649; PMCID: PMC362554.
  248. Kimelman D, Abraham JA, Haaparanta T, Palisi TM, Kirschner MW. The presence of fibroblast growth factor in the frog egg: its role as a natural mesoderm inducer. Science. 1988 Nov 18; 242(4881):1053-6. PMID: 3194757.
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  249. Mitchison T, Kirschner M. Cytoskeletal dynamics and nerve growth. Neuron. 1988 Nov; 1(9):761-72. PMID: 3078414.
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  250. Cyert MS, Scherson T, Kirschner MW. Monoclonal antibodies specific for thiophosphorylated proteins recognize Xenopus MPF. Dev Biol. 1988 Sep; 129(1):209-16. PMID: 3044877.
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  251. Schulze E, Kirschner M. New features of microtubule behaviour observed in vivo. Nature. 1988 Jul 28; 334(6180):356-9. PMID: 3393227.
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  252. Drubin D, Kobayashi S, Kellogg D, Kirschner M. Regulation of microtubule protein levels during cellular morphogenesis in nerve growth factor-treated PC12 cells. J Cell Biol. 1988 May; 106(5):1583-91. PMID: 3131347; PMCID: PMC2115058.
  253. Cyert MS, Kirschner MW. Regulation of MPF activity in vitro. Cell. 1988 Apr 22; 53(2):185-95. PMID: 2834064.
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  254. Koshland DE, Mitchison TJ, Kirschner MW. Polewards chromosome movement driven by microtubule depolymerization in vitro. Nature. 1988 Feb 11; 331(6156):499-504. PMID: 3340202.
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  255. Lee G, Cowan N, Kirschner M. The primary structure and heterogeneity of tau protein from mouse brain. Science. 1988 Jan 15; 239(4837):285-8. PMID: 3122323.
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  256. Huitorel P, Kirschner MW. The polarity and stability of microtubule capture by the kinetochore. J Cell Biol. 1988 Jan; 106(1):151-9. PMID: 3339086; PMCID: PMC2114942.
  257. Kimelman D, Kirschner M. Synergistic induction of mesoderm by FGF and TGF-beta and the identification of an mRNA coding for FGF in the early Xenopus embryo. Cell. 1987 Dec 04; 51(5):869-77. PMID: 3479265.
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  258. Wolin SL, Krohne G, Kirschner MW. A new lamin in Xenopus somatic tissues displays strong homology to human lamin A. EMBO J. 1987 Dec 01; 6(12):3809-18. PMID: 3428277; PMCID: PMC553853.
  259. Krohne G, Wolin SL, McKeon FD, Franke WW, Kirschner MW. Nuclear lamin LI of Xenopus laevis: cDNA cloning, amino acid sequence and binding specificity of a member of the lamin B subfamily. EMBO J. 1987 Dec 01; 6(12):3801-8. PMID: 3428276; PMCID: PMC553852.
  260. Mitchison TJ, Kirschner MW. Some thoughts on the partitioning of tubulin between monomer and polymer under conditions of dynamic instability. Cell Biophys. 1987 Dec; 11:35-55. PMID: 2450668.
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  261. Gard DL, Kirschner MW. Microtubule assembly in cytoplasmic extracts of Xenopus oocytes and eggs. J Cell Biol. 1987 Nov; 105(5):2191-201. PMID: 3680377; PMCID: PMC2114874.
  262. Schulze E, Asai DJ, Bulinski JC, Kirschner M. Posttranslational modification and microtubule stability. J Cell Biol. 1987 Nov; 105(5):2167-77. PMID: 3316248; PMCID: PMC2114866.
  263. Gard DL, Kirschner MW. A microtubule-associated protein from Xenopus eggs that specifically promotes assembly at the plus-end. J Cell Biol. 1987 Nov; 105(5):2203-15. PMID: 2890645; PMCID: PMC2114854.
  264. Kimelman D, Kirschner M, Scherson T. The events of the midblastula transition in Xenopus are regulated by changes in the cell cycle. Cell. 1987 Feb 13; 48(3):399-407. PMID: 3802197.
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  265. Karsenti E, Bravo R, Kirschner M. Phosphorylation changes associated with the early cell cycle in Xenopus eggs. Dev Biol. 1987 Feb; 119(2):442-53. PMID: 3803713.
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  266. Schulze E, Kirschner M. Dynamic and stable populations of microtubules in cells. J Cell Biol. 1987 Feb; 104(2):277-88. PMID: 3543024; PMCID: PMC2114424.
  267. Drubin DG, Kirschner MW. Tau protein function in living cells. J Cell Biol. 1986 Dec; 103(6 Pt 2):2739-46. PMID: 3098742; PMCID: PMC2114585.
  268. Kirschner MW, Mitchison T. Microtubule dynamics. Nature. 1986 Dec 18-31; 324(6098):621. PMID: 3796729.
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  269. Mitchison T, Evans L, Schulze E, Kirschner M. Sites of microtubule assembly and disassembly in the mitotic spindle. Cell. 1986 May 23; 45(4):515-27. PMID: 3708686.
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  271. Kristofferson D, Mitchison T, Kirschner M. Direct observation of steady-state microtubule dynamics. J Cell Biol. 1986 Mar; 102(3):1007-19. PMID: 3005332; PMCID: PMC2114110.
  272. Schulze E, Kirschner M. Microtubule dynamics in interphase cells. J Cell Biol. 1986 Mar; 102(3):1020-31. PMID: 3512576; PMCID: PMC2114101.
  273. McKeon FD, Kirschner MW, Caput D. Homologies in both primary and secondary structure between nuclear envelope and intermediate filament proteins. Nature. 1986 Feb 6-12; 319(6053):463-8. PMID: 3453101.
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  274. Drubin D, Kobayashi S, Kirschner M. Association of tau protein with microtubules in living cells. Ann N Y Acad Sci. 1986; 466:257-68. PMID: 2873777.
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  275. Drubin D, Kirschner M. Purification of tau protein from brain. Methods Enzymol. 1986; 134:156-60. PMID: 3102900.
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  276. Mitchison TJ, Kirschner MW. Isolation of mammalian centrosomes. Methods Enzymol. 1986; 134:261-8. PMID: 3821566.
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  277. Kirschner M, Schulze E. Morphogenesis and the control of microtubule dynamics in cells. J Cell Sci Suppl. 1986; 5:293-310. PMID: 3477556.
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  278. Drubin DG, Feinstein SC, Shooter EM, Kirschner MW. Nerve growth factor-induced neurite outgrowth in PC12 cells involves the coordinate induction of microtubule assembly and assembly-promoting factors. J Cell Biol. 1985 Nov; 101(5 Pt 1):1799-807. PMID: 2997236; PMCID: PMC2113947.
  279. Caron JM, Jones AL, Kirschner MW. Autoregulation of tubulin synthesis in hepatocytes and fibroblasts. J Cell Biol. 1985 Nov; 101(5 Pt 1):1763-72. PMID: 3902854; PMCID: PMC2113958.
  280. Caron JM, Jones AL, Rall LB, Kirschner MW. Autoregulation of tubulin synthesis in enucleated cells. Nature. 1985 Oct 17-23; 317(6038):648-51. PMID: 4058574.
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  281. Mitchison TJ, Kirschner MW. Properties of the kinetochore in vitro. I. Microtubule nucleation and tubulin binding. J Cell Biol. 1985 Sep; 101(3):755-65. PMID: 4030893; PMCID: PMC2113742.
  282. Mitchison TJ, Kirschner MW. Properties of the kinetochore in vitro. II. Microtubule capture and ATP-dependent translocation. J Cell Biol. 1985 Sep; 101(3):766-77. PMID: 4030894; PMCID: PMC2113737.
  283. Miake-Lye R, Kirschner MW. Induction of early mitotic events in a cell-free system. Cell. 1985 May; 41(1):165-75. PMID: 3888406.
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  284. Evans L, Mitchison T, Kirschner M. Influence of the centrosome on the structure of nucleated microtubules. J Cell Biol. 1985 Apr; 100(4):1185-91. PMID: 4038981; PMCID: PMC2113747.
  285. Gard DL, Kirschner MW. A polymer-dependent increase in phosphorylation of beta-tubulin accompanies differentiation of a mouse neuroblastoma cell line. J Cell Biol. 1985 Mar; 100(3):764-74. PMID: 2857724; PMCID: PMC2113523.
  286. Gerhart J, Wu M, Cyert M, Kirschner M. M-phase promoting factors from eggs of Xenopus laevis. Cytobios. 1985; 43(174S):335-47. PMID: 3908000.
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  287. Mitchison T, Kirschner M. Microtubule assembly nucleated by isolated centrosomes. Nature. 1984 Nov 15-21; 312(5991):232-7. PMID: 6504137.
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  288. Mitchison T, Kirschner M. Dynamic instability of microtubule growth. Nature. 1984 Nov 15-21; 312(5991):237-42. PMID: 6504138.
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  289. Forbes DJ, Kirschner MW, Caput D, Dahlberg JE, Lund E. Differential expression of multiple U1 small nuclear RNAs in oocytes and embryos of Xenopus laevis. Cell. 1984 Oct; 38(3):681-9. PMID: 6207932.
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  290. Newport JW, Kirschner MW. Regulation of the cell cycle during early Xenopus development. Cell. 1984 Jul; 37(3):731-42. PMID: 6378387.
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  291. Karsenti E, Newport J, Kirschner M. Respective roles of centrosomes and chromatin in the conversion of microtubule arrays from interphase to metaphase. J Cell Biol. 1984 Jul; 99(1 Pt 2):47s-54s. PMID: 6235234; PMCID: PMC2275591.
  292. Karsenti E, Newport J, Hubble R, Kirschner M. Interconversion of metaphase and interphase microtubule arrays, as studied by the injection of centrosomes and nuclei into Xenopus eggs. J Cell Biol. 1984 May; 98(5):1730-45. PMID: 6725396; PMCID: PMC2113192.
  293. Karsenti E, Kobayashi S, Mitchison T, Kirschner M. Role of the centrosome in organizing the interphase microtubule array: properties of cytoplasts containing or lacking centrosomes. J Cell Biol. 1984 May; 98(5):1763-76. PMID: 6725398; PMCID: PMC2113175.
  294. Gerhart J, Wu M, Kirschner M. Cell cycle dynamics of an M-phase-specific cytoplasmic factor in Xenopus laevis oocytes and eggs. J Cell Biol. 1984 Apr; 98(4):1247-55. PMID: 6425302; PMCID: PMC2113233.
  295. Drubin DG, Caput D, Kirschner MW. Studies on the expression of the microtubule-associated protein, tau, during mouse brain development, with newly isolated complementary DNA probes. J Cell Biol. 1984 Mar; 98(3):1090-7. PMID: 6421824; PMCID: PMC2113151.
  296. Lee G, Hynes R, Kirschner M. Temporal and spatial regulation of fibronectin in early Xenopus development. Cell. 1984 Mar; 36(3):729-40. PMID: 6697394.
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  297. McKeon FD, Tuffanelli DL, Kobayashi S, Kirschner MW. The redistribution of a conserved nuclear envelope protein during the cell cycle suggests a pathway for chromosome condensation. Cell. 1984 Jan; 36(1):83-92. PMID: 6420073.
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  298. Calarco-Gillam PD, Siebert MC, Hubble R, Mitchison T, Kirschner M. Centrosome development in early mouse embryos as defined by an autoantibody against pericentriolar material. Cell. 1983 Dec; 35(3 Pt 2):621-9. PMID: 6652679.
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  299. Ubbels GA, Hara K, Koster CH, Kirschner MW. Evidence for a functional role of the cytoskeleton in determination of the dorsoventral axis in Xenopus laevis eggs. J Embryol Exp Morphol. 1983 Oct; 77:15-37. PMID: 6689175.
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  300. Forbes DJ, Kirschner MW, Newport JW. Spontaneous formation of nucleus-like structures around bacteriophage DNA microinjected into Xenopus eggs. Cell. 1983 Aug; 34(1):13-23. PMID: 6224569.
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  301. Miake-Lye R, Newport J, Kirschner M. Maturation-promoting factor induces nuclear envelope breakdown in cycloheximide-arrested embryos of Xenopus laevis. J Cell Biol. 1983 Jul; 97(1):81-91. PMID: 6345556; PMCID: PMC2112507.
  302. Forbes DJ, Kornberg TB, Kirschner MW. Small nuclear RNA transcription and ribonucleoprotein assembly in early Xenopus development. J Cell Biol. 1983 Jul; 97(1):62-72. PMID: 6190822; PMCID: PMC2112482.
  303. Hill TL, Kirschner MW. Regulation of microtubule and actin filament assembly--disassembly by associated small and large molecules. Int Rev Cytol. 1983; 84:185-234. PMID: 6358104.
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  304. Newport J, Kirschner M. A major developmental transition in early Xenopus embryos: II. Control of the onset of transcription. Cell. 1982 Oct; 30(3):687-96. PMID: 7139712.
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  305. Newport J, Kirschner M. A major developmental transition in early Xenopus embryos: I. characterization and timing of cellular changes at the midblastula stage. Cell. 1982 Oct; 30(3):675-86. PMID: 6183003.
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  306. Ring D, Hubble R, Kirschner M. Mitosis in a cell with multiple centrioles. J Cell Biol. 1982 Sep; 94(3):549-56. PMID: 7130271; PMCID: PMC2112222.
  307. Cleveland D, Kirschner M. Autoregulatory control of the expression of alpha- and beta-tubulins: implications for microtubule assembly. Cold Spring Harb Symp Quant Biol. 1982; 46 Pt 1:171-83. PMID: 6286212.
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  308. Hill TL, Kirschner MW. Bioenergetics and kinetics of microtubule and actin filament assembly-disassembly. Int Rev Cytol. 1982; 78:1-125. PMID: 6128332.
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  309. Hill TL, Kirschner MW. Subunit treadmilling of microtubules or actin in the presence of cellular barriers: possible conversion of chemical free energy into mechanical work. Proc Natl Acad Sci U S A. 1982 Jan; 79(2):490-4. PMID: 6952202; PMCID: PMC345769.
  310. Gerhart J, Ubbels G, Black S, Hara K, Kirschner M. A reinvestigation of the role of the grey crescent in axis formation in xenopus laevis. Nature. 1981 Aug 06; 292(5823):511-6. PMID: 7195987.
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  311. Cleveland DW, Lopata MA, Sherline P, Kirschner MW. Unpolymerized tubulin modulates the level of tubulin mRNAs. Cell. 1981 Aug; 25(2):537-46. PMID: 6116546.
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  312. Cleveland DW, Hughes SH, Stubblefield E, Kirschner MW, Varmus HE. Multiple alpha and beta tubulin genes represent unlinked and dispersed gene families. J Biol Chem. 1981 Mar 25; 256(6):3130-4. PMID: 6259149.
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  313. Valenzuela P, Quiroga M, Zaldivar J, Rutter WJ, Kirschner MW, Cleveland DW. Nucleotide and corresponding amino acid sequences encoded by alpha and beta tubulin mRNAs. Nature. 1981 Feb 19; 289(5799):650-5. PMID: 7464932.
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  314. Sánchez F, Natzle JE, Cleveland DW, Kirschner MW, McCarthy BJ. A dispersed multigene family encoding tubulin in Drosophila melanogaster. Cell. 1980 Dec; 22(3):845-54. PMID: 6780200.
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  315. Heuser JE, Kirschner MW. Filament organization revealed in platinum replicas of freeze-dried cytoskeletons. J Cell Biol. 1980 Jul; 86(1):212-34. PMID: 6893451; PMCID: PMC2110639.
  316. Kirschner MW. Implications of treadmilling for the stability and polarity of actin and tubulin polymers in vivo. J Cell Biol. 1980 Jul; 86(1):330-4. PMID: 6893454; PMCID: PMC2110666.
  317. Cleveland DW, Lopata MA, MacDonald RJ, Cowan NJ, Rutter WJ, Kirschner MW. Number and evolutionary conservation of alpha- and beta-tubulin and cytoplasmic beta- and gamma-actin genes using specific cloned cDNA probes. Cell. 1980 May; 20(1):95-105. PMID: 6893015.
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  318. Kirschner MW, Hara K. A new method of local vital staining of amphibian embryos using ficoll and "crystals" of Nile Red. Mikroskopie. 1980 Feb; 36(1-2):12-5. PMID: 6155645.
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  319. Hara K, Tydeman P, Kirschner M. A cytoplasmic clock with the same period as the division cycle in Xenopus eggs. Proc Natl Acad Sci U S A. 1980 Jan; 77(1):462-6. PMID: 6928638; PMCID: PMC348291.
  320. Cleveland DW, Spiegelman BM, Kirschner MW. Conservation of microtubule associated proteins. Isolation and characterization of tau and the high molecular weight microtubule associated protein from chicken brain and from mouse fibroblasts and comparison to the corresponding mammalian brain proteins. J Biol Chem. 1979 Dec 25; 254(24):12670-8. PMID: 227904.
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  321. Summers K, Kirschner MW. Characteristics of the polar assembly and disassembly of microtubules observed in vitro by darkfield light microscopy. J Cell Biol. 1979 Oct; 83(1):205-17. PMID: 511939; PMCID: PMC2110448.
  322. Spiegelman BM, Lopata MA, Kirschner MW. Aggregation of microtubule initiation sites preceding neurite outgrowth in mouse neuroblastoma cells. Cell. 1979 Feb; 16(2):253-63. PMID: 455435.
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  323. Spiegelman BM, Lopata MA, Kirschner MW. Multiple sites for the initiation of microtubule assembly in mammalian cells. Cell. 1979 Feb; 16(2):239-52. PMID: 455434.
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  324. Cleveland DW, Kirschner MW, Cowan NJ. Isolation of separate mRNAs for alpha- and beta-tubulin and characterization of the corresponding in vitro translation products. Cell. 1978 Nov; 15(3):1021-31. PMID: 728983.
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  325. Heidemann SR, Kirschner MW. Induced formation of asters and cleavage furrows in oocytes of Xenopus laevis during in vitro maturation. J Exp Zool. 1978 Jun; 204(3):431-44. PMID: 660144.
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  326. Connolly JA, Kalnins VI, Cleveland DW, Kirschner MW. Intracellular localization of the high molecular weight microtubule accessory protein by indirect immunofluorescence. J Cell Biol. 1978 Mar; 76(3):781-6. PMID: 344329; PMCID: PMC2110001.
  327. Penningroth SM, Kirschner MW. Nucleotide specificity in microtubule assembly in vitro. Biochemistry. 1978 Feb 21; 17(4):734-40. PMID: 623742.
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  328. Yang YR, Kirschner MW, Schachman HK. Aspartate transcarbamoylase (Escherichia coli): preparation of subunits. Methods Enzymol. 1978; 51:35-41. PMID: 357897.
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  329. Kirschner MW. Microtubule assembly and nucleation. Int Rev Cytol. 1978; 54:1-71. PMID: 391755.
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  330. Spiegelman BM, Penningroth SM, Kirschner MW. Turnover of tubulin and the N site GTP in Chinese hamster ovary cells. Cell. 1977 Nov; 12(3):587-600. PMID: 562716.
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  331. Cleveland DW, Hwo SY, Kirschner MW. Physical and chemical properties of purified tau factor and the role of tau in microtubule assembly. J Mol Biol. 1977 Oct 25; 116(2):227-47. PMID: 146092.
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  332. Cleveland DW, Hwo SY, Kirschner MW. Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin. J Mol Biol. 1977 Oct 25; 116(2):207-25. PMID: 599557.
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  333. Penningroth SM, Kirschner MW. Nucleotide binding and phosphorylation in microtubule assembly in vitro. J Mol Biol. 1977 Oct 05; 115(4):643-73. PMID: 201762.
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  334. Connolly JA, Kalnins VI, Cleveland DW, Kirschner MW. Immunoflourescent staining of cytoplasmic and spindle microtubules in mouse fibroblasts with antibody to tau protein. Proc Natl Acad Sci U S A. 1977 Jun; 74(6):2437-40. PMID: 329285; PMCID: PMC432187.
  335. Heidemann SR, Sander G, Kirschner MW. Evidence for a functional role of RNA in centrioles. Cell. 1977 Mar; 10(3):337-50. PMID: 403009.
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  336. Witman GB, Cleveland DW, Weingarten MD, Kirschner MW. Tubulin requires tau for growth onto microtubule initiating sites. Proc Natl Acad Sci U S A. 1976 Nov; 73(11):4070-4. PMID: 1069293; PMCID: PMC431332.
  337. Kirschner MW, Honig LS, Williams RC. Quantitative electron microscopy of microtubule assembly in vitro. J Mol Biol. 1975 Dec 05; 99(2):263-76. PMID: 1206704.
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  338. Heidemann SR, Kirschner MW. Aster formation in eggs of Xenopus laevis. Induction by isolated basal bodies. J Cell Biol. 1975 Oct; 67(1):105-17. PMID: 1236852; PMCID: PMC2109591.
  339. Kirschner MW, Suter M, Weingarten M, Littman D. The role of rings in the assembly of microtubules in vitro. Ann N Y Acad Sci. 1975 Jun 30; 253:90-106. PMID: 1056761.
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  340. Weingarten MD, Suter MM, Littman DR, Kirschner MW. Properties of the depolymerization products of microtubules from mammalian brain. Biochemistry. 1974 Dec 31; 13(27):5529-37. PMID: 4457112.
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  341. Springer MS, Kirschner MW, Schachman HK. A difference sedimentation equilibrium technique for measuring small changes in molecular weight. I. Theory and computer simulation. Biochemistry. 1974 Aug 27; 13(18):3718-26. PMID: 4850196.
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  342. Kirschner MW, Williams RC, Weingarten M, Gerhart JC. Microtubules from mammalian brain: some properties of their depolymerization products and a proposed mechanism of assembly and disassembly. Proc Natl Acad Sci U S A. 1974 Apr; 71(4):1159-63. PMID: 4524627; PMCID: PMC388183.
  343. Kirschner MW, Williams RC. The mechanism of microtubule assembly in vitro. J Supramol Struct. 1974; 2(2-4):412-28. PMID: 4474574.
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