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Matthew Nehs, M.D.

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Biography
Hope College, Holland MIBS05/2002Biology and Chemistry
University of Michigan, Ann Arbor, MIMD05/2006Medical School
Brigham and Women's / Harvard Medical School, Boston, MA6/2013General Surgery
Brigham and Women's / Harvard Medical School, Boston, MA7/2014Endocrine Surgery
2019
Thyroid Cancer Survivors Network Research Grant
2016
Matson Award for Faculty Teaching of Residents
2013
Francis D. Moore Chief Resident Award
2012
Harvard Medical School - Excellence in Surgery Research Award
2012
Harvard Medical School Resident Teaching Award
2011
Best Basic Science Oral Presentation – American Association of Endocrine Surgeons
2011
Harvard Medical School Resident Teaching Award
2010
First place, Resident Competition – Massachusetts Chapter of the ACS
2010
Excellence in Research Award – American College of Surgeons
2010
Best Basic Science Oral Presentation – American Association of Endocrine Surgeons
2009
Mannick Research Award – Role of B-Raf in aggressive papillary thyroid cancer
2009
First place, Basic Science Poster – American Association of Endocrine Surgeons

Overview
My scientific interest lies in interaction between metabolism and aggressive malignancies like anaplastic thyroid cancer and adrenocortical carcinoma. We are currently testing the ways in which diet influences tumor growth and also how it modifies the response to treatment.


My clinical practice is a high-volume Endocrine Surgery practice where I treat patients with diseases of the thyroid, parathyroid, and adrenal glands.

Thyroid: I perform more than 100 thyroidectomies per year for both benign and malignant indications. I have a particular interest in treating the most advance thyroid malignancies (Anaplastic, poorly differentiated, medullary).

Parathyroid: Primary hyperparathyroidism is an under-diagnosed condition that can affect bone mineral density, neurocognitive function, and kidney stone formation. Most PHPT is caused by a single parathyroid adenoma in the neck and can be readily cured with surgery.

Adrenal: Diseases of the adrenal glands range from benign functional disorders (pheochromocytoma, aldosteronoma, adrenal Cushing syndrome from an adenoma) to advanced malignancies (Adrenocortical carcinoma and malignant tumors from other sites that metastasize to the adrenal gland). Most adrenalectomies are performed with minimally invasive techniques.

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Pappa T, Ahmadi S, Marqusee E, Johnson HL, Nehs MA, Cho NL, Barletta JA, Lorch JH, Doherty GM, Lindeman NI, Alexander EK, Landa I. Oncogenic Mutations in PI3K/AKT/mTOR Pathway Effectors Associate with Worse Prognosis in BRAFV600E -Driven Papillary Thyroid Cancer Patients. Clin Cancer Res. 2021 Jun 04. PMID: 34088725.
    Citations:    Fields:    
  2. Nehs MA. Invited Commentary. J Am Coll Surg. 2021 Jun; 232(6):821-822. PMID: 34030844.
    Citations:    Fields:    
  3. Cohn A, Nehs M, Chan J, Vaidya A. Casting a Wide Net. N Engl J Med. 2021 Apr 01; 384(13):e50. PMID: 33789015.
    Citations:    Fields:    Translation:Humans
  4. Wrenn SM, Pandian TK, Gartland RM, Fong ZV, Nehs MA. Diabetes mellitus and hyperglycemia are associated with inferior oncologic outcomes in adrenocortical carcinoma. Langenbecks Arch Surg. 2021 Feb 01. PMID: 33521844.
    Citations:    Fields:    
  5. Wong KS, Dong F, Telatar M, Lorch JH, Alexander EK, Marqusee E, Cho NL, Nehs MA, Doherty GM, Afkhami M, Barletta JA. Papillary Thyroid Carcinoma with High-Grade Features Versus Poorly Differentiated Thyroid Carcinoma: An Analysis of Clinicopathologic and Molecular Features and Outcome. Thyroid. 2021 06; 31(6):933-940. PMID: 33143568.
    Citations: 2     Fields:    
  6. Wong KS, Lorch JH, Alexander EK, Marqusee E, Cho NL, Nehs MA, Doherty GM, Barletta JA. Histopathologic Features and Clinical Outcome of Anaplastic Thyroid Carcinoma with a Minor Anaplastic Component. Endocr Pathol. 2020 Sep; 31(3):283-290. PMID: 32445173.
    Citations: 1     Fields:    Translation:Humans
  7. Kuo LE, Angell TE, Pandian TK, Moore AL, Alexander EK, Barletta JA, Gawande AA, Lorch JH, Marqusee E, Moore FD, Nehs MA, Doherty GM, Cho NL. Completion Thyroidectomy is Less Common Following Updated 2015 American Thyroid Association Guidelines. Ann Surg Oncol. 2021 Jan; 28(1):484-491. PMID: 32583197.
    Citations:    Fields:    Translation:Humans
  8. Wachtel H, Roses RE, Kuo LE, Lindeman BM, Nehs MA, Tavakkoli A, Parangi S, Hodin RA, Fraker DL, James BC, Carr AA, Wang TS, Solórzano CC, Lubitz CC. Adrenalectomy for Secondary Malignancy: Patients, Outcomes, and Indications. Ann Surg. 2020 May 18. PMID: 32427760.
    Citations:    Fields:    
  9. Wong KS, Chen TY, Higgins SE, Howitt BE, Lorch JH, Alexander EK, Marqusee E, Cho NL, Nehs MA, Doherty GM, Barletta JA. A potential diagnostic pitfall for hobnail variant of papillary thyroid carcinoma. Histopathology. 2020 Apr; 76(5):707-713. PMID: 31811787.
    Citations: 4     Fields:    Translation:Humans
  10. Angell TE, Maurer R, Wang Z, Kim MI, Alexander CA, Barletta JA, Benson CB, Cibas ES, Cho NL, Doherty GM, Doubilet PM, Frates MC, Gawande AA, Krane JF, Marqusee E, Moore FD, Nehs MA, Larsen PR, Alexander EK. A Cohort Analysis of Clinical and Ultrasound Variables Predicting Cancer Risk in 20,001 Consecutive Thyroid Nodules. J Clin Endocrinol Metab. 2019 11 01; 104(11):5665-5672. PMID: 31310316.
    Citations: 4     Fields:    Translation:Humans
  11. Vaidya A, Nehs M, Kilbridge K. Treatment of Adrenocortical Carcinoma. Surg Pathol Clin. 2019 Dec; 12(4):997-1006. PMID: 31672303.
    Citations: 5     Fields:    Translation:Humans
  12. Aggarwal A, Yuan Z, Barletta JA, Lorch JH, Nehs MA. Ketogenic diet combined with antioxidant N-acetylcysteine inhibits tumor growth in a mouse model of anaplastic thyroid cancer. Surgery. 2020 01; 167(1):87-93. PMID: 31521320.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  13. Wong KS, Lorch JH, Alexander EK, Marqusee E, Cho NL, Nehs MA, Doherty GM, Barletta JA. Prognostic Significance of Extent of Invasion in Poorly Differentiated Thyroid Carcinoma. Thyroid. 2019 09; 29(9):1255-1261. PMID: 31397224.
    Citations: 4     Fields:    Translation:Humans
  14. Wong KS, Lorch JH, Alexander EK, Nehs MA, Nowak JA, Hornick JL, Barletta JA. Clinicopathologic Features of Mismatch Repair-Deficient Anaplastic Thyroid Carcinomas. Thyroid. 2019 05; 29(5):666-673. PMID: 30869569.
    Citations: 2     Fields:    Translation:HumansCells
  15. Wong KS, Higgins SE, Marqusee E, Nehs MA, Angell T, Barletta JA. Tall Cell Variant of Papillary Thyroid Carcinoma: Impact of Change in WHO Definition and Molecular Analysis. Endocr Pathol. 2019 Mar; 30(1):43-48. PMID: 30565013.
    Citations: 5     Fields:    Translation:Humans
  16. Harris EJ, Hanna GJ, Chau N, Rabinowits G, Haddad R, Margalit DN, Schoenfeld J, Tishler RB, Barletta JA, Nehs M, Janne P, Huang J, Groden P, Kacew A, Lorch J. Everolimus in Anaplastic Thyroid Cancer: A Case Series. Front Oncol. 2019; 9:106. PMID: 30863722.
    Citations: 6     
  17. Lindeman BM, Nehs MA, Angell TE, Alexander EK, Gawande AA, Moore FD, Doherty GM, Cho NL. Effect of Noninvasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP) on Malignancy Rates in Thyroid Nodules: How to Counsel Patients on Extent of Surgery. Ann Surg Oncol. 2019 Jan; 26(1):93-97. PMID: 30341576.
    Citations: 2     Fields:    Translation:HumansCells
  18. Lindeman B, Gawande AA, Moore FD, Cho NL, Doherty GM, Nehs MA. The Posterior Adiposity Index: A Quantitative Selection Tool for Adrenalectomy Approach. J Surg Res. 2019 01; 233:26-31. PMID: 30502257.
    Citations: 3     Fields:    Translation:Humans
  19. Nehs MA. Invited Commentary. J Am Coll Surg. 2018 06; 226(6):959-960. PMID: 29803254.
    Citations:    Fields:    Translation:HumansCells
  20. Wang Z, Vyas CM, Van Benschoten O, Nehs MA, Moore FD, Marqusee E, Krane JF, Kim MI, Heller HT, Gawande AA, Frates MC, Doubilet PM, Doherty GM, Cho NL, Cibas ES, Benson CB, Barletta JA, Zavacki AM, Larsen PR, Alexander EK, Angell TE. Quantitative Analysis of the Benefits and Risk of Thyroid Nodule Evaluation in Patients =70 Years Old. Thyroid. 2018 04; 28(4):465-471. PMID: 29608439.
    Citations: 5     Fields:    Translation:Humans
  21. Angell TE, Vyas CM, Barletta JA, Cibas ES, Cho NL, Doherty GM, Gawande AA, Howitt BE, Krane JF, Marqusee E, Strickland KC, Alexander EK, Moore FD, Nehs MA. Reasons Associated with Total Thyroidectomy as Initial Surgical Management of an Indeterminate Thyroid Nodule. Ann Surg Oncol. 2018 May; 25(5):1410-1417. PMID: 29520656.
    Citations: 2     Fields:    Translation:Humans
  22. Strickland KC, Eszlinger M, Paschke R, Angell TE, Alexander EK, Marqusee E, Nehs MA, Jo VY, Lowe A, Vivero M, Hollowell M, Qian X, Wieczorek T, French CA, Teot LA, Cibas ES, Lindeman NI, Krane JF, Barletta JA. Molecular Testing of Nodules with a Suspicious or Malignant Cytologic Diagnosis in the Setting of Non-Invasive Follicular Thyroid Neoplasm with Papillary-Like Nuclear Features (NIFTP). Endocr Pathol. 2018 Mar; 29(1):68-74. PMID: 29396809.
    Citations: 4     Fields:    Translation:Humans
  23. Hamidi M, Sullivan M, Hunter G, Hamberg L, Cho NL, Gawande AA, Doherty GM, Moore FD, Nehs MA. 4D-CT is Superior to Ultrasound and Sestamibi for Localizing Recurrent Parathyroid Disease. Ann Surg Oncol. 2018 May; 25(5):1403-1409. PMID: 29484563.
    Citations: 9     Fields:    Translation:Humans
  24. Hanna GJ, Busaidy NL, Chau NG, Wirth LJ, Barletta JA, Calles A, Haddad RI, Kraft S, Cabanillas ME, Rabinowits G, O'Neill A, Limaye SA, Alexander EK, Moore FD, Misiwkeiwicz K, Thomas T, Nehs M, Marqusee E, Lee SL, Jänne PA, Lorch JH. Genomic Correlates of Response to Everolimus in Aggressive Radioiodine-refractory Thyroid Cancer: A Phase II Study. Clin Cancer Res. 2018 04 01; 24(7):1546-1553. PMID: 29301825.
    Citations: 13     Fields:    Translation:HumansCTClinical Trials
  25. Angell TE, Vyas CM, Medici M, Wang Z, Barletta JA, Benson CB, Cibas ES, Cho NL, Doherty GM, Doubilet PM, Frates MC, Gawande AA, Heller HT, Kim MI, Krane JF, Marqusee E, Moore FD, Nehs MA, Zavacki AM, Larsen PR, Alexander EK. Differential Growth Rates of Benign vs. Malignant Thyroid Nodules. J Clin Endocrinol Metab. 2017 12 01; 102(12):4642-4647. PMID: 29040691.
    Citations: 3     Fields:    Translation:Humans
  26. Sharma G, Aycart MA, O'Mara L, Havens J, Nehs M, Shimizu N, Smink DS, Gravereaux E, Gates JD, Askari R. A cadaveric procedural anatomy simulation course improves video-based assessment of operative performance. J Surg Res. 2018 03; 223:64-71. PMID: 29433887.
    Citations:    Fields:    Translation:Humans
  27. Mito JK, Alexander EK, Angell TE, Barletta JA, Nehs MA, Cibas ES, Krane JF. A modified reporting approach for thyroid FNA in the NIFTP era: A 1-year institutional experience. Cancer Cytopathol. 2017 Nov; 125(11):854-864. PMID: 28902465.
    Citations: 3     Fields:    Translation:Humans
  28. Wong KS, Strickland KC, Angell TE, Nehs MA, Alexander EK, Cibas ES, Krane JF, Howitt BE, Barletta JA. The Flip Side of NIFTP: an Increase in Rates of Unfavorable Histologic Parameters in the Remainder of Papillary Thyroid Carcinomas. Endocr Pathol. 2017 Jun; 28(2):171-176. PMID: 28271380.
    Citations: 6     Fields:    Translation:Humans
  29. Sullivan MC, Graham PH, Alexander EK, Ruan DT, Nehs MA, Gawande AA, Moore FD, Howitt BE, Strickland KC, Krane JF, Barletta JA, Cho NL. Prevalence of Contralateral Tumors in Patients with Follicular Variant of Papillary Thyroid Cancer. J Am Coll Surg. 2017 Jun; 224(6):1021-1027. PMID: 28017809.
    Citations: 2     Fields:    Translation:Humans
  30. Gibson WJ, Ruan DT, Paulson VA, Barletta JA, Hanna GJ, Kraft S, Calles A, Nehs MA, Moore FD, Taylor-Weiner A, Wala JA, Zack TI, Lee TC, Fennessy FM, Alexander EK, Thomas T, Janne PA, Garraway LA, Carter SL, Beroukhim R, Lorch JH, Van Allen EM. Genomic Heterogeneity and Exceptional Response to Dual Pathway Inhibition in Anaplastic Thyroid Cancer. Clin Cancer Res. 2017 May 01; 23(9):2367-2373. PMID: 27797976.
    Citations: 10     Fields:    Translation:HumansCells
  31. Kakarmath S, Heller HT, Alexander CA, Cibas ES, Krane JF, Barletta JA, Lindeman NI, Frates MC, Benson CB, Gawande AA, Cho NL, Nehs M, Moore FD, Marqusee E, Kim MI, Larsen PR, Kwong N, Angell TE, Alexander EK. Clinical, Sonographic, and Pathological Characteristics of RAS-Positive Versus BRAF-Positive Thyroid Carcinoma. J Clin Endocrinol Metab. 2016 12; 101(12):4938-4944. PMID: 27689252.
    Citations: 4     Fields:    Translation:Humans
  32. Pitt SC, Hernandez RA, Nehs MA, Gawande AA, Moore FD, Ruan DT, Cho NL. Identification of Novel Oncogenic Mutations in Thyroid Cancer. J Am Coll Surg. 2016 06; 222(6):1036-1043.e2. PMID: 27010584.
    Citations: 5     Fields:    Translation:Humans
  33. Liu X, Medici M, Kwong N, Angell TE, Marqusee E, Kim MI, Larsen PR, Cho NL, Nehs MA, Ruan DT, Gawande A, Moore F, Barletta J, Krane JF, Cibas ES, Yang T, Alexander EK. Bethesda Categorization of Thyroid Nodule Cytology and Prediction of Thyroid Cancer Type and Prognosis. Thyroid. 2016 Feb; 26(2):256-61. PMID: 26563459.
    Citations: 14     Fields:    Translation:Humans
  34. Campbell MJ, McCoy KL, Shen WT, Carty SE, Lubitz CC, Moalem J, Nehs M, Holm T, Greenblatt DY, Press D, Feng X, Siperstein AE, Mitmaker E, Benay C, Tabah R, Oltmann SC, Chen H, Sippel RS, Brekke A, Vriens MR, Lodewijk L, Stephen AE, Nagar S, Angelos P, Ghanem M, Prescott JD, Zeiger MA, Aragon Han P, Sturgeon C, Elaraj DM, Nixon IJ, Patel SG, Bayles SW, Heneghan R, Ochieng P, Guerrero MA, Ruan DT. A multi-institutional international study of risk factors for hematoma after thyroidectomy. Surgery. 2013 Dec; 154(6):1283-89; discussion 1289-91. PMID: 24206619.
    Citations: 23     Fields:    Translation:Humans
  35. Nehs MA, Ruan DT, Gawande AA, Moore FD, Cho NL. Bilateral neck exploration decreases operative time compared to minimally invasive parathyroidectomy in patients with discordant imaging. World J Surg. 2013 Jul; 37(7):1614-7. PMID: 23519294.
    Citations: 3     Fields:    Translation:Humans
  36. Nehs MA, Nucera C, Nagarkatti SS, Sadow PM, Morales-Garcia D, Hodin RA, Parangi S. Late intervention with anti-BRAF(V600E) therapy induces tumor regression in an orthotopic mouse model of human anaplastic thyroid cancer. Endocrinology. 2012 Feb; 153(2):985-94. PMID: 22202162.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  37. Lin CI, Barletta JA, Nehs MA, Morris ZS, Donner DB, Whang EE, Jeong JW, Kimura S, Moore FD, Ruan DT. Thyroid-specific knockout of the tumor suppressor mitogen-inducible gene 6 activates epidermal growth factor receptor signaling pathways and suppresses nuclear factor-?B activity. Surgery. 2011 Dec; 150(6):1295-302. PMID: 22136853.
    Citations: 3     Fields:    Translation:AnimalsCells
  38. Nehs MA, Lin CI, Kozono DE, Whang EE, Cho NL, Zhu K, Moalem J, Moore FD, Ruan DT. Necroptosis is a novel mechanism of radiation-induced cell death in anaplastic thyroid and adrenocortical cancers. Surgery. 2011 Dec; 150(6):1032-9. PMID: 22136818.
    Citations: 42     Fields:    Translation:HumansCells
  39. Christopher C. Barney, Kacie Greenheck, Matthew A. Nehs, Lisa N. Hardy. Journal of Thermal Biology. Endogenous angiotensin II and the regulation of oxygen consumption and colonic temperature in rats. 2011.
  40. Nehs MA, Ruan DT. Minimally invasive adrenal surgery: an update. Curr Opin Endocrinol Diabetes Obes. 2011 Jun; 18(3):193-7. PMID: 21494137.
    Citations: 9     Fields:    Translation:Humans
  41. Nucera C, Nehs MA, Nagarkatti SS, Sadow PM, Mekel M, Fischer AH, Lin PS, Bollag GE, Lawler J, Hodin RA, Parangi S. Targeting BRAFV600E with PLX4720 displays potent antimigratory and anti-invasive activity in preclinical models of human thyroid cancer. Oncologist. 2011; 16(3):296-309. PMID: 21355020.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  42. Daniel T. Ruan, MD and Matthew A. Nehs, MD. The Handbook of Endocrine Surgery - Adrenal Cortical Cancer. 2011; 357-365.
  43. Nehs MA, Nagarkatti S, Nucera C, Hodin RA, Parangi S. Thyroidectomy with neoadjuvant PLX4720 extends survival and decreases tumor burden in an orthotopic mouse model of anaplastic thyroid cancer. Surgery. 2010 Dec; 148(6):1154-62; discussion 1162. PMID: 21134546.
    Citations: 20     Fields:    Translation:Animals
  44. Nucera C, Porrello A, Antonello ZA, Mekel M, Nehs MA, Giordano TJ, Gerald D, Benjamin LE, Priolo C, Puxeddu E, Finn S, Jarzab B, Hodin RA, Pontecorvi A, Nose V, Lawler J, Parangi S. B-Raf(V600E) and thrombospondin-1 promote thyroid cancer progression. Proc Natl Acad Sci U S A. 2010 Jun 08; 107(23):10649-54. PMID: 20498063.
    Citations: 84     Fields:    Translation:HumansAnimalsCells
  45. Mekel M, Stephen AE, Gaz RD, Randolph GW, Richer S, Perry ZH, Lubitz CC, Nehs MA, Parangi S, Hodin RA. Surgical drains can be safely avoided in lateral neck dissections for papillary thyroid cancer. Am J Surg. 2010 Apr; 199(4):485-90. PMID: 20359568.
    Citations: 1     Fields:    Translation:Humans
  46. Khalpey, Z., Nehs, M.A., ElBardissi, A.W., Semel, M. and Tullius, S.G. NDT Plus. The importance of prevention of calciphylaxis in patients who are at risk and the potential fallibility of calcimimetics in the treatment of calciphylaxis for patients with secondary hyperparathyroidism. 2010; (3):68-70.
  47. Nucera C, Nehs MA, Mekel M, Zhang X, Hodin R, Lawler J, Nose V, Parangi S. A novel orthotopic mouse model of human anaplastic thyroid carcinoma. Thyroid. 2009 Oct; 19(10):1077-84. PMID: 19772429.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  48. Khalpey Z, Nehs MA, ElBardissi AW, Semel M, Tullius SG. The importance of prevention of calciphylaxis in patients who are at risk and the potential fallibility of calcimimetics in the treatment of calciphylaxis for patients with secondary hyperparathyroidism. NDT Plus. 2010 Feb; 3(1):68-70. PMID: 25949409.
    Citations: 2     
  49. Kwasnik, E.M. and Nehs, M.A. General Surgery News. Post-Herniorrhaphy Chronic Pain: A Template for Improvement. 2009; 4(36).
  50. Miller BS, England BG, Nehs M, Burney RE, Doherty GM, Gauger PG. Interpretation of intraoperative parathyroid hormone monitoring in patients with baseline parathyroid hormone levels of <100 pg/mL. Surgery. 2006 Dec; 140(6):883-9; discussion 889-90. PMID: 17188134.
    Citations: 15     Fields:    Translation:Humans
  51. Sabel MS, Nehs MA, Su G, Lowler KP, Ferrara JL, Chang AE. Immunologic response to cryoablation of breast cancer. Breast Cancer Res Treat. 2005 Mar; 90(1):97-104. PMID: 15770533.
    Citations: 44     Fields:    Translation:AnimalsCells
  52. Sabel MS, Nehs MA. Immunologic approaches to breast cancer treatment. Surg Oncol Clin N Am. 2005 Jan; 14(1):1-31, v. PMID: 15541997.
    Citations:    Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.