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profileJatin Mahesh Vyas, M.D., Ph.D.

TitleAssociate Professor of Medicine
InstitutionMassachusetts General Hospital
DepartmentMedicine
AddressMassachusetts General Hospital
Infectious Disease, GRJ 504
55 Fruit St
Boston MA 02114
Phone617/643-6444
Fax617/643-6443
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My research interests focus on the immune responses to fungal pathogens. Charged with the responsibility to protect a host from pathogenic microorganisms, the immune system detects, neutralizes, and eliminates these invaders using many different specialized cells. One arm of the immune system deploys sentinels throughout the body. Their purpose is two-fold. First, professional antigen presenting cells (APCs) capture invading pathogens by phagocytosis and degrade them before they cause additional harm to the host. Second, APCs must “deliver the message” about the presence of pathogens in the periphery to T cells located in regional lymph nodes in order to amplify the immune response. How does an APC talk to the T cell? Both cells come together and form a cell-cell synapse whereby the T cell interrogates the surface of the APC for the presence of a pathogen-specific signal that, when present, activates the T cell. Specialized immune proteins, termed class II MHC molecules, are heterodimeric protein complexes that present this signal. Dendritic cells (DCs) are potent professional APCs that express abundant class II MHC molecules and possess the unique capacity to activate naïve T cells. In order to serve as an effective APC, newly-captured pathogens must be shuttled to the endolysosomes for degradation. To accomplish this task, APCs place pathogens into membrane-delimited compartments termed phagosomes. These compartments undergo a series of membrane modifications, drop their pH and activate proteases which facilitate degradation of the cargo. The biomolecular mechanism of phagosome maturation is incompletely understood including the identity and kinetics of association and dissociation of most proteins on phagosomal membranes. When properly folded, class II MHC molecules form a pocket for pathogen-derived peptides (protein fragments). In the endolysosome, a specialized compartment within the APC, class II MHC molecules associate with pathogen-derived peptides and traffic from intracellular compartments to the cell surface. Antigen presentation requires the coordinated efforts of multiple host proteins including members of the tetraspanin superfamily, though their exact function in this process remains poorly understood.
When the process of antigen processing and presentation works well, the host is protected from a number of virulent microorganisms. Failure of an effective immune response, however, can lead to overwhelming infection and possibly death. This failure is caused typically by specific cellular defects in the immune system as seen in HIV infection, older age, or administration of immunosuppressive medications. My major goal is to understand the rules that govern the fate of fungal pathogens including Aspergillus fumigatus, Candida albicans and Cryptococcus neoformans upon phagocytosis by real-time visualization of professional APCs expressing fluorescently-tagged proteins relevant to antigen processing and presentation using spinning-disk confocal microscopy.

I also serve as the tenth Program Director for the Massachusetts General Hospital Department of Medicine. I oversee the educational activities for the interns and residents. The MGH Internal Medicine Residency program has a long and world-renowned tradition of training leaders in academic medicine and biomedical science. The foundation of our program is rigorous clinical training that emphasizes clinical excellence, teamwork, leadership and career development. Our dedicated teaching faculty, resident research opportunities and experiences in international health and the local community ensure that our residents become outstanding physicians.

We enjoy strong house staff camaraderie and a supportive community in which diversity is celebrated. We take pride in training leaders in clinical and basic research, clinical practice, education, health policy, global health, administration and others. The outstanding achievements of our graduates remain the strongest affirmation of the goals of the training program


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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R21AI109303     (VYAS, JATIN M)Jul 1, 2015 - Jun 30, 2017
NIH/NIAID
Systems Analysis of Innate Immune Responses to Fungal-Derived Carbohydrates
Role: Principal Investigator

R01AI097519     (VYAS, JATIN M)Jul 23, 2013 - Jun 30, 2017
NIH/NIAID
The role of TLR9 on Aspergillus fumigatus phagosomes
Role: Principal Investigator

R01AI092084     (VYAS, JATIN M)Jun 15, 2011 - May 31, 2016
NIH/NIAID
Functional Role of the Tetraspanin CD82/Kai1 in Innate and Adaptive Immunity
Role: Principal Investigator

K08AI057999     (VYAS, JATIN M)Apr 1, 2004 - Dec 31, 2009
NIH/NIAID
Modulation of Dendritic Cell Function by Cytomegalovirus
Role: Principal Investigator

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Simpkin AL, Vyas JM, Armstrong KA. Diagnostic Reasoning: An Endangered Competency in Internal Medicine Training. Ann Intern Med. 2017 Oct 03; 167(7):507-508. PMID: 28892818.
    View in: PubMed
  2. Reedy JL, Negoro PE, Feliu M, Lord AK, Khan NS, Lukason DP, Wiederhold NP, Tam JM, Mansour MK, Patterson TF, Vyas JM. The Carbohydrate Lectin Receptor Dectin-1 Mediates the Immune Response to Exserohilum rostratum. Infect Immun. 2017 Mar; 85(3). PMID: 28031265.
    View in: PubMed
  3. Truong-Bolduc QC, Khan NS, Vyas JM, Hooper DC. Tet38 Efflux Pump Affects Staphylococcus aureus Internalization by Epithelial Cells through Interaction with CD36 and Contributes to Bacterial Escape from Acidic and Nonacidic Phagolysosomes. Infect Immun. 2017 Feb; 85(2). PMID: 27956597.
    View in: PubMed
  4. McCluskey SM, Schuetz P, Abers MS, Bearnot B, Morales ME, Hoffman D, Patel S, Rosario L, Chiappa V, Parry BA, Callahan RT, Bond SA, Lewandrowski K, Binder W, Filbin MR, Vyas JM, Mansour MK. Serial Procalcitonin as a Predictor of Bacteremia and Need for Intensive Care Unit Care in Adults With Pneumonia, Including Those With Highest Severity: A Prospective Cohort Study. Open Forum Infect Dis. 2017; 4(1):ofw238. PMID: 28480236.
    View in: PubMed
  5. Schlimgen R, Howard J, Wooley D, Thompson M, Baden LR, Yang OO, Christiani DC, Mostoslavsky G, Diamond DV, Duane EG, Byers K, Winters T, Gelfand JA, Fujimoto G, Hudson TW, Vyas JM. Risks Associated With Lentiviral Vector Exposures and Prevention Strategies. J Occup Environ Med. 2016 Dec; 58(12):1159-1166. PMID: 27930472.
    View in: PubMed
  6. Safavieh M, Coarsey C, Esiobu N, Memic A, Vyas JM, Shafiee H, Asghar W. Advances in Candida detection platforms for clinical and point-of-care applications. Crit Rev Biotechnol. 2017 Jun; 37(4):441-458. PMID: 27093473.
    View in: PubMed
  7. Tam JM, Mansour MK, Acharya M, Sokolovska A, Timmons AK, Lacy-Hulbert A, Vyas JM. The Role of Autophagy-Related Proteins in Candida albicans Infections. Pathogens. 2016 Mar 29; 5(2). PMID: 27043636; PMCID: PMC4931385.
  8. Acharya M, Sokolovska A, Tam JM, Conway KL, Stefani C, Raso F, Mukhopadhyay S, Feliu M, Paul E, Savill J, Hynes RO, Xavier RJ, Vyas JM, Stuart LM, Lacy-Hulbert A. av Integrins combine with LC3 and atg5 to regulate Toll-like receptor signalling in B cells. Nat Commun. 2016 Mar 11; 7:10917. PMID: 26965188; PMCID: PMC4792966.
  9. Li X, Cullere X, Nishi H, Saggu G, Durand E, Mansour MK, Tam JM, Song XY, Lin X, Vyas JM, Mayadas T. PKC-d activation in neutrophils promotes fungal clearance. J Leukoc Biol. 2016 Sep; 100(3):581-8. PMID: 26965632.
    View in: PubMed
  10. Terry AR, Kahle KT, Larvie M, Vyas JM, Stemmer-Rachamimov A. CASE RECORDS of the MASSACHUSETTS GENERAL HOSPITAL. Case 5-2016. A 43-Year-Old Man with Altered Mental Status and a History of Alcohol Use. N Engl J Med. 2016 Feb 18; 374(7):671-80. PMID: 26886525.
    View in: PubMed
  11. Abers MS, Ghebremichael MS, Timmons AK, Warren HS, Poznansky MC, Vyas JM. A Critical Reappraisal of Prolonged Neutropenia as a Risk Factor for Invasive Pulmonary Aspergillosis. Open Forum Infect Dis. 2016 Jan; 3(1):ofw036. PMID: 27006961; PMCID: PMC4800458.
  12. Khan NS, Kasperkovitz PV, Timmons AK, Mansour MK, Tam JM, Seward MW, Reedy JL, Puranam S, Feliu M, Vyas JM. Dectin-1 Controls TLR9 Trafficking to Phagosomes Containing ß-1,3 Glucan. J Immunol. 2016 Mar 01; 196(5):2249-61. PMID: 26829985; PMCID: PMC4761466 [Available on 03/01/17].
  13. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chowdhury K, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, Cianfanelli V, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-222. PMID: 26799652; PMCID: PMC4835977 [Available on 01/21/17].
  14. Truong-Bolduc QC, Bolduc GR, Medeiros H, Vyas JM, Wang Y, Hooper DC. Role of the Tet38 Efflux Pump in Staphylococcus aureus Internalization and Survival in Epithelial Cells. Infect Immun. 2015 Nov; 83(11):4362-72. PMID: 26324534; PMCID: PMC4598397.
  15. Jones CN, Dimisko L, Forrest K, Judice K, Poznansky MC, Markmann JF, Vyas JM, Irimia D. Human Neutrophils Are Primed by Chemoattractant Gradients for Blocking the Growth of Aspergillus fumigatus. J Infect Dis. 2016 Feb 01; 213(3):465-75. PMID: 26272935; PMCID: PMC4704668 [Available on 02/01/17].
  16. Begun J, Lassen KG, Jijon HB, Baxt LA, Goel G, Heath RJ, Ng A, Tam JM, Kuo SY, Villablanca EJ, Fagbami L, Oosting M, Kumar V, Schenone M, Carr SA, Joosten LA, Vyas JM, Daly MJ, Netea MG, Brown GD, Wijmenga C, Xavier RJ. Integrated Genomics of Crohn's Disease Risk Variant Identifies a Role for CLEC12A in Antibacterial Autophagy. Cell Rep. 2015 Jun 30; 11(12):1905-18. PMID: 26095365; PMCID: PMC4507440.
  17. Klassert TE, Hanisch A, Bräuer J, Klaile E, Heyl KA, Mansour MK, Tam JM, Vyas JM, Slevogt H. Erratum to: Modulatory role of vitamin A on the Candida albicans-induced immune response in human monocytes. Med Microbiol Immunol. 2014 Dec; 203(6):425. PMID: 25298302.
    View in: PubMed
  18. Klassert TE, Hanisch A, Bräuer J, Klaile E, Heyl KA, Mansour MK, Mansour MM, Tam JM, Vyas JM, Slevogt H. Modulatory role of vitamin A on the Candida albicans-induced immune response in human monocytes. Med Microbiol Immunol. 2014 Dec; 203(6):415-24. PMID: 25129478; PMCID: PMC4232755.
  19. Tam JM, Mansour MK, Khan NS, Seward M, Puranam S, Tanne A, Sokolovska A, Becker CE, Acharya M, Baird MA, Choi AM, Davidson MW, Segal BH, Lacy-Hulbert A, Stuart LM, Xavier RJ, Vyas JM. Dectin-1-dependent LC3 recruitment to phagosomes enhances fungicidal activity in macrophages. J Infect Dis. 2014 Dec 01; 210(11):1844-54. PMID: 24842831; PMCID: PMC4271056.
  20. Kasper L, Seider K, Gerwien F, Allert S, Brunke S, Schwarzmüller T, Ames L, Zubiria-Barrera C, Mansour MK, Becken U, Barz D, Vyas JM, Reiling N, Haas A, Haynes K, Kuchler K, Hube B. Identification of Candida glabrata genes involved in pH modulation and modification of the phagosomal environment in macrophages. PLoS One. 2014; 9(5):e96015. PMID: 24789333; PMCID: PMC4006850.
  21. Mansour MK, Reedy JL, Tam JM, Vyas JM. Macrophage Cryptococcus interactions: an update. Curr Fungal Infect Rep. 2014 Mar 01; 8(1):109-115. PMID: 24660045.
    View in: PubMed
  22. Vyas JM, González RG, Pierce VM. Case records of the Massachusetts General Hospital. Case 15-2013. A 76-year-old man with fever, worsening renal function, and altered mental status. N Engl J Med. 2013 May 16; 368(20):1919-27. PMID: 23675661.
    View in: PubMed
  23. Mansour MK, Tam JM, Khan NS, Seward M, Davids PJ, Puranam S, Sokolovska A, Sykes DB, Dagher Z, Becker C, Tanne A, Reedy JL, Stuart LM, Vyas JM. Dectin-1 activation controls maturation of ß-1,3-glucan-containing phagosomes. J Biol Chem. 2013 May 31; 288(22):16043-54. PMID: 23609446; PMCID: PMC3668760.
  24. Grimm MJ, Vethanayagam RR, Almyroudis NG, Dennis CG, Khan AN, D'Auria AC, Singel KL, Davidson BA, Knight PR, Blackwell TS, Hohl TM, Mansour MK, Vyas JM, Röhm M, Urban CF, Kelkka T, Holmdahl R, Segal BH. Monocyte- and macrophage-targeted NADPH oxidase mediates antifungal host defense and regulation of acute inflammation in mice. J Immunol. 2013 Apr 15; 190(8):4175-84. PMID: 23509361; PMCID: PMC3622122.
  25. Huett A, Heath RJ, Begun J, Sassi SO, Baxt LA, Vyas JM, Goldberg MB, Xavier RJ. The LRR and RING domain protein LRSAM1 is an E3 ligase crucial for ubiquitin-dependent autophagy of intracellular Salmonella Typhimurium. Cell Host Microbe. 2012 Dec 13; 12(6):778-90. PMID: 23245322; PMCID: PMC3785244.
  26. Mansour MK, Tam JM, Vyas JM. The cell biology of the innate immune response to Aspergillus fumigatus. Ann N Y Acad Sci. 2012 Dec; 1273:78-84. PMID: 23230841; PMCID: PMC3531818.
  27. Vyas JM. Insights into dendritic cell function using advanced imaging modalities. Virulence. 2012 Nov 15; 3(7):690-4. PMID: 23221474; PMCID: PMC3545951.
  28. Vyas JM. The dendritic cell: the general of the army. Virulence. 2012 Nov 15; 3(7):601-2. PMID: 23221475; PMCID: PMC3545941.
  29. Vyas JM, Marasco WA. Fatal fulminant hepatic failure from adenovirus in allogeneic bone marrow transplant patients. Case Rep Infect Dis. 2012; 2012:463569. PMID: 22928129; PMCID: PMC3426185.
  30. Tam JM, Mansour MK, Khan NS, Yoder NC, Vyas JM. Use of fungal derived polysaccharide-conjugated particles to probe Dectin-1 responses in innate immunity. Integr Biol (Camb). 2012 Feb; 4(2):220-7. PMID: 22200052; PMCID: PMC3346694.
  31. Coleman JJ, Muhammed M, Kasperkovitz PV, Vyas JM, Mylonakis E. Fusarium pathogenesis investigated using Galleria mellonella as a heterologous host. Fungal Biol. 2011 Dec; 115(12):1279-89. PMID: 22115447; PMCID: PMC3224342.
  32. Mansour MK, Vyas JM, Levitz SM. Dynamic virulence: real-time assessment of intracellular pathogenesis links Cryptococcus neoformans phenotype with clinical outcome. MBio. 2011; 2(5). PMID: 21954307; PMCID: PMC3181469.
  33. Kasperkovitz PV, Khan NS, Tam JM, Mansour MK, Davids PJ, Vyas JM. Toll-like receptor 9 modulates macrophage antifungal effector function during innate recognition of Candida albicans and Saccharomyces cerevisiae. Infect Immun. 2011 Dec; 79(12):4858-67. PMID: 21947771; PMCID: PMC3232661.
  34. Tam JM, Castro CE, Heath RJ, Mansour MK, Cardenas ML, Xavier RJ, Lang MJ, Vyas JM. Use of an optical trap for study of host-pathogen interactions for dynamic live cell imaging. J Vis Exp. 2011 Jul 28; (53). PMID: 21841755; PMCID: PMC3197446.
  35. Vyas JM. The duality of Aspergillus terreus: Differential immune responses to distinct conidia. Virulence. 2011 May-Jun; 2(3):181-4. PMID: 21636969.
    View in: PubMed
  36. Modi P, Rizvi J, Pal B, Bharadwaj R, Trivedi P, Trivedi A, Patel K, Shah K, Vyas J, Sharma S, Shah K, Chauhan R, Trivedi H. Laparoscopic kidney transplantation: an initial experience. Am J Transplant. 2011 Jun; 11(6):1320-4. PMID: 21486384.
    View in: PubMed
  37. Tam JM, Castro CE, Heath RJ, Cardenas ML, Xavier RJ, Lang MJ, Vyas JM. Control and manipulation of pathogens with an optical trap for live cell imaging of intercellular interactions. PLoS One. 2010 Dec 31; 5(12):e15215. PMID: 21217821; PMCID: PMC3013098.
  38. Xia Y, Cortez-Retamozo V, Niederkofler V, Salie R, Chen S, Samad TA, Hong CC, Arber S, Vyas JM, Weissleder R, Pittet MJ, Lin HY. Dragon (repulsive guidance molecule b) inhibits IL-6 expression in macrophages. J Immunol. 2011 Feb 01; 186(3):1369-76. PMID: 21187450; PMCID: PMC3670585.
  39. Artavanis-Tsakonas K, Kasperkovitz PV, Papa E, Cardenas ML, Khan NS, Van der Veen AG, Ploegh HL, Vyas JM. The tetraspanin CD82 is specifically recruited to fungal and bacterial phagosomes prior to acidification. Infect Immun. 2011 Mar; 79(3):1098-106. PMID: 21149584; PMCID: PMC3067484.
  40. Kasperkovitz PV, Cardenas ML, Vyas JM. TLR9 is actively recruited to Aspergillus fumigatus phagosomes and requires the N-terminal proteolytic cleavage domain for proper intracellular trafficking. J Immunol. 2010 Dec 15; 185(12):7614-22. PMID: 21059889; PMCID: PMC3600358.
  41. Bender Ignacio RA, Liu AY, Sohani AR, Vyas JM. Hodgkin's lymphoma masquerading as vertebral osteomyelitis in a man with diabetes: a case report. J Med Case Rep. 2010 Apr 06; 4:102. PMID: 20370895; PMCID: PMC2907869.
  42. Vyas JM, Van der Veen AG, Ploegh HL. The known unknowns of antigen processing and presentation. Nat Rev Immunol. 2008 Aug; 8(8):607-18. PMID: 18641646; PMCID: PMC2735460.
  43. Vyas JM, Telford SR, Robbins GK. Treatment of refractory Babesia microti infection with atovaquone-proguanil in an HIV-infected patient: case report. Clin Infect Dis. 2007 Dec 15; 45(12):1588-90. PMID: 18190320.
    View in: PubMed
  44. Vyas JM, Telford III S, Robbins GK. Treatment of Refractory Babesia microti Infection with Atovaquone-Proguanil in an HIV-Infected Patient: Case Report. Clinical Infectious Disease. 2007; 45:1588-1590.
  45. Vyas JM, Kim YM, Artavanis-Tsakonas K, Love JC, Van der Veen AG, Ploegh HL. Tubulation of class II MHC compartments is microtubule dependent and involves multiple endolysosomal membrane proteins in primary dendritic cells. J Immunol. 2007 Jun 01; 178(11):7199-210. PMID: 17513769; PMCID: PMC2806821.
  46. Vyas JM, Kasmar A, Holden J, Chang H, Hohmann E. Abdominal Actinomycosis after Laparascopic Cholecystectomy: Case Reports and Review. Clinical Infectious Diseases. 2007; 44:e1-e4.
  47. Vyas JM, Kasmar A, Chang HR, Holden J, Hohmann E. Abdominal abscesses due to actinomycosis after laparoscopic cholecystectomy: case reports and review. Clin Infect Dis. 2007 Jan 15; 44(2):e1-4. PMID: 17173208.
    View in: PubMed
  48. Trivedi V, Zhang SC, Castoreno AB, Stockinger W, Shieh EC, Vyas JM, Frickel EM, Nohturfft A. Immunoglobulin G signaling activates lysosome/phagosome docking. Proc Natl Acad Sci U S A. 2006 Nov 28; 103(48):18226-31. PMID: 17110435; PMCID: PMC1838734.
  49. Artavanis-Tsakonas K, Love JC, Ploegh HL, Vyas JM. Recruitment of CD63 to Cryptococcus neoformans phagosomes requires acidification. Proc Natl Acad Sci U S A. 2006 Oct 24; 103(43):15945-50. PMID: 17043215; PMCID: PMC1635107.
  50. Wozniak KL, Vyas JM, Levitz SM. In vivo role of dendritic cells in a murine model of pulmonary cryptococcosis. Infect Immun. 2006 Jul; 74(7):3817-24. PMID: 16790753; PMCID: PMC1489690.
  51. Gewurz B, Vyas JM, and Ploegh H.L. Subversion of adaptive immunity: immune evasion of T cells. Human Herpesviruses: Biology, Therapy and Immunoprophylaxis. Editor: Ann M. Arvin, MD. 2006.
  52. Niess JH, Brand S, Gu X, Landsman L, Jung S, McCormick BA, Vyas JM, Boes M, Ploegh HL, Fox JG, Littman DR, Reinecker HC. CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science. 2005 Jan 14; 307(5707):254-8. PMID: 15653504.
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  53. Fiebiger E, Hirsch C, Vyas JM, Gordon E, Ploegh HL, Tortorella D. Dissection of the dislocation pathway for type I membrane proteins with a new small molecule inhibitor, eeyarestatin. Mol Biol Cell. 2004 Apr; 15(4):1635-46. PMID: 14767067; PMCID: PMC379262.
  54. Vyas JM, Marasco, WA. Fatal fulminant hepatic failure from adenovirus in allogenic bone marrow transplant patients. Infectious Disease Society of America. 2003.
  55. Jatin M Vyas, MD, PhD Mary Jane Ferraro, PhD, MPH. Antibiotic susceptibility testing in specific clinical situations. 2003.
  56. Jatin M Vyas, MD, PhD Mary Jane Ferraro, PhD, MPH. Overview of antibacterial susceptibility testing. 2003.
  57. Dow SW, Roberts A, Vyas J, Rodgers J, Rich RR, Orme I, Potter TA. Immunization with f-Met peptides induces immune reactivity against Mycobacterium tuberculosis. Tuber Lung Dis. 2000; 80(1):5-13. PMID: 10897379.
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  58. Vyas JM, Rodgers JR, Rich RR. H-2M3a violates the paradigm for major histocompatibility complex class I peptide binding. J Exp Med. 1995 May 01; 181(5):1817-25. PMID: 7722457; PMCID: PMC2191989.
  59. Vyas JM, Lamphear JL and Rich RR. The language of immunology. Clinical Immunology: Principles and Practice. Editor: Robert R. Rich. 1995; G1-8.
  60. Vyas JM. The peptide binding specificity of the MHC class I-b molecule, H-2M3a. 1994.
  61. Shawar SM, Vyas JM, Rodgers JR, Rich RR. Antigen presentation by major histocompatibility complex class I-B molecules. Annu Rev Immunol. 1994; 12:839-80. PMID: 8011299.
    View in: PubMed
  62. Vyas JM, Rich RR, Howell DD, Shawar SM, Rodgers JR. Availability of endogenous peptides limits expression of an M3a-Ld major histocompatibility complex class I chimera. J Exp Med. 1994 Jan 01; 179(1):155-65. PMID: 8270862; PMCID: PMC2191314.
  63. Shawar SM, Vyas JM, Shen E, Rodgers JR, Rich RR. Differential amino-terminal anchors for peptide binding to H-2M3a or H-2Kb and H-2Db. J Immunol. 1993 Jul 01; 151(1):201-10. PMID: 7686932.
    View in: PubMed
  64. Vyas JM, Shawar SM, Rodgers JR, Cook RG, Rich RR. Biochemical specificity of H-2M3a. Stereospecificity and space-filling requirements at position 1 maintain N-formyl peptide binding. J Immunol. 1992 Dec 01; 149(11):3605-11. PMID: 1431130.
    View in: PubMed
  65. Shawar SM, Vyas JM, Rodgers JR, Cook RG, Rich RR. Specialized functions of major histocompatibility complex class I molecules. II. Hmt binds N-formylated peptides of mitochondrial and prokaryotic origin. J Exp Med. 1991 Oct 01; 174(4):941-4. PMID: 1919442; PMCID: PMC2118972.
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