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Kira O'Neil Bona, M.D.

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Biography
2011
American Academy of Hospice and Palliative Medicine (AAHPM) Research Scholar
2013
ASCO Young Investigator Award
2013
St. Baldrick's Foundation Fellow
2016
NIH/NCI K07
2018
Child Health Award
2018
Radcliffe Exploratory Seminar Leader

Overview
The Bona Lab at Dana-Farber Cancer Institute studies outcome disparities in childhood cancer with a focus on improving childhood cancer outcomes by systematically considering social determinants of health as risk factors in the clinical trial setting and potential targets for intervention.

One in five children diagnosed with cancer in the United States lives in poverty, and we have demonstrated that poverty is associated with higher rates of relapse, decreased overall survival, and higher symptom burden even when children are treated on clinical trials at large academic medical centers. Poverty-associated outcome disparities in this context highlight the stubborn reality that increased understanding of tumor and host biology and the development of rational therapeutics may be necessary, but not sufficient, to achieve the cures we desire. Our research is based on the premise that transformative improvements in outcome are most likely to be achieved if we expand our conceptual model of discovery and intervention beyond biology to include social determinants of health outcomes at every stage in pediatric cancer research.

?The mission of the Bona Lab is to ensure that every child diagnosed with cancer has an equal chance of survival and optimal quality-of-life during and after treatment. We aim to achieve this by uniting traditional outcomes and health services research with the robust clinical trial model of discovery and care which has steadily improved outcomes for children with cancer over the last half century. Our team is highly collaborative and leverages the expertise of colleagues conducting multicenter clinical trials and basic science translational research to consider risk factors for disease outcome from a novel lens.

Mentoring
Available: 04/05/22, Expires: 06/01/23

My current research includes 1) clinical-trial embedded prospective investigations of poverty and outcomes (relapse, survival, late effects, utilization) in childhood ALL and neuroblastoma; 2) design and evaluation of poverty-targeted interventions for the pediatric oncology clinical setting; and 3) Collaborative translational investigation of physiological responses/chemotherapy resistance due to poverty-associated stress. My research group is broadly focused on investigating social determinants if health and outcome disparities in subspecialty pediatrics.


Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R03CA259894 (ZHOU, ERIC S) Apr 1, 2021 - Mar 31, 2023
    NIH
    A Preventive Care Approach to Mitigate the Impact of Pediatric ALL Treatment on Sleep
    Role: Co-Principal Investigator
  2. K07CA211847 (BONA, KIRA O) Sep 20, 2016 - Feb 28, 2022
    NIH
    Material Hardship as a Targetable Measure of Poverty in Pediatric Cancer
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Newman H, Li Y, Liu H, Myers RM, Tam V, DiNofia A, Wray L, Rheingold SR, Callahan C, White C, Baniewicz D, Winestone LE, Kadauke S, Diorio C, June CH, Getz K, Aplenc R, Teachey DT, Maude SL, Grupp SA, Bona K, Barz Leahy A. Impact of poverty and neighborhood opportunity on outcomes for children treated with CD19-directed CAR T-cell therapy. Blood. 2022 Nov 09. PMID: 36351239.
    Citations:    Fields:    
  2. Umaretiya PJ, Fisher L, Altschuler A, Kushi LH, Chao CR, Vega B, Rodrigues G, Josephs I, Brock KE, Buchanan S, Casperson M, Fasciano KM, Kolevska T, Lakin JR, Lefebvre A, Schwartz CM, Shalman DM, Wall CB, Wiener L, Bona K, Mack JW. "The simple life experiences that every other human gets": Desire for normalcy among adolescents and young adults with advanced cancer. Pediatr Blood Cancer. 2023 Jan; 70(1):e30035. PMID: 36308744.
    Citations:    Fields:    
  3. Kahn JM, Stevenson K, Beauchemin M, Koch VB, Cole PD, Welch JJG, Gage-Bouchard E, Karsenty C, Silverman LB, Kelly KM, Bona K. Oral Mercaptopurine Adherence in Pediatric Acute Lymphoblastic Leukemia: A Survey Study From the Dana-Farber Cancer Institute Acute Lymphoblastic Leukemia Consortium. J Pediatr Hematol Oncol Nurs. 2022 Oct 12; 27527530221122685. PMID: 36221984.
    Citations:    
  4. Bona K, Keating NL. Addressing Social Determinants of Health: Now Is the Time. J Natl Cancer Inst. 2022 Sep 21. PMID: 36130283.
    Citations:    Fields:    
  5. Aziz-Bose R, Zheng DJ, Umaretiya PJ, Ilcisin L, Stevenson K, Koch V, Valenzuela A, Cole PD, Gennarini LM, Kahn JM, Kelly KM, Tran TH, Michon B, Welch JJG, Silverman LB, Wolfe J, Bona K. Feasibility of oncology clinical trial-embedded evaluation of social determinants of health. Pediatr Blood Cancer. 2022 11; 69(11):e29933. PMID: 36069432.
    Citations:    Fields:    Translation:Humans
  6. Beauchemin M, Santacroce SJ, Bona K, Dang H, Alexander S, Allen K, De Los Santos C, Fisher B, Muñeton-Castaño Y, Ponce O, Vargas S, Sugalski A, Sung L, Parsons S. Rationale and design of Children's Oncology Group (COG) study ACCL20N1CD: financial distress during treatment of acute lymphoblastic leukemia in the United States. BMC Health Serv Res. 2022 Jun 28; 22(1):832. PMID: 35764995; PMCID: PMC9237978.
    Citations:    Fields:    Translation:Humans
  7. Umaretiya PJ, Vinci RJ, Bona K. A Structural Racism Framework to Guide Health Equity Interventions in Pediatric Oncology. Pediatrics. 2022 05 01; 149(5). PMID: 35490282.
    Citations:    Fields:    Translation:Humans
  8. Elgarten CW, Otto WR, Shenton L, Stein MT, Horowitz J, Aftandilian C, Arnold SD, Bona KO, Caywood E, Collier AB, Gramatges MM, Henry M, Lotterman C, Maloney K, Modi AJ, Mian A, Mody R, Morgan E, Raetz EA, Verma A, Winick N, Wilkes JJ, Yu JC, Aplenc R, Fisher BT, Getz KD. Risk of bacterial bloodstream infection does not vary by central-line type during neutropenic periods in pediatric acute myeloid leukemia. Infect Control Hosp Epidemiol. 2022 Apr 25; 1-8. PMID: 35465865.
    Citations:    Fields:    
  9. Umaretiya PJ, Ilowite M, Fisher L, Bakitas M, Currie ER, Gilbertson-White S, Lindley L, Roeland EJ, Mack JW, Bona K. Missing Voices: Lessons Learned from Nonparticipating Caregivers in Palliative Care Research. J Palliat Med. 2022 03; 25(3):455-460. PMID: 34981972; PMCID: PMC8968850.
    Citations:    Fields:    Translation:Humans
  10. Getz KD, Szymczak JE, Li Y, Madding R, Huang YV, Aftandilian C, Arnold SD, Bona KO, Caywood E, Collier AB, Gramatges MM, Henry M, Lotterman C, Maloney K, Mian A, Mody R, Morgan E, Raetz EA, Rubnitz J, Verma A, Winick N, Wilkes JJ, Yu JC, Fisher BT, Aplenc R. Medical Outcomes, Quality of Life, and Family Perceptions for Outpatient vs Inpatient Neutropenia Management After Chemotherapy for Pediatric Acute Myeloid Leukemia. JAMA Netw Open. 2021 10 01; 4(10):e2128385. PMID: 34709389.
    Citations:    Fields:    Translation:Humans
  11. Zheng DJ, Umaretiya PJ, Schwartz ER, Al-Sayegh H, Raphael JL, van Litsenburg RRL, Ma C, Muriel AC, Bona K. Disparities in pediatric psychosocial oncology utilization. Pediatr Blood Cancer. 2021 11; 68(11):e29342. PMID: 34519425; PMCID: PMC8463506.
    Citations:    Fields:    Translation:Humans
  12. Boyden JY, Hill DL, Nye RT, Bona K, Johnston EE, Hinds P, Friebert S, Kang TI, Hays R, Hall M, Wolfe J, Feudtner C. Pediatric Palliative Care Parents' Distress, Financial Difficulty, and Child Symptoms. J Pain Symptom Manage. 2022 02; 63(2):271-282. PMID: 34425212; PMCID: PMC8816828.
    Citations: 3     Fields:    Translation:Humans
  13. Umaretiya PJ, Wolfe J, Bona K. Naming the Problem: A Structural Racism Framework to Examine Disparities in Palliative Care. J Pain Symptom Manage. 2022 05; 63(5):e461-e463. PMID: 34400277.
    Citations: 2     Fields:    Translation:Humans
  14. Umaretiya PJ, Li A, McGovern A, Ma C, Wolfe J, Bona K. Race, ethnicity, and goal-concordance of end-of-life palliative care in pediatric oncology. Cancer. 2021 10 15; 127(20):3893-3900. PMID: 34255377.
    Citations: 1     Fields:    Translation:Humans
  15. Umaretiya PJ, Revette A, Seo A, Flamand Y, Ilcisin L, Zheng DJ, Bhatia S, Wolfe J, Bona K. PediCARE: Development of a poverty-targeted intervention for pediatric cancer. Pediatr Blood Cancer. 2021 10; 68(10):e29195. PMID: 34190405; PMCID: PMC8384686.
    Citations: 2     Fields:    Translation:Humans
  16. Aristizabal P, Winestone LE, Umaretiya P, Bona K. Disparities in Pediatric Oncology: The 21st Century Opportunity to Improve Outcomes for Children and Adolescents With Cancer. Am Soc Clin Oncol Educ Book. 2021 Jun; 41:e315-e326. PMID: 34061564; PMCID: PMC9126642.
    Citations: 2     Fields:    Translation:Humans
  17. Zheng DJ, Li A, Ma C, Ribeiro KB, Diller L, Bona K, Marron JM. Socioeconomic disparities in survival after high-risk neuroblastoma treatment with modern therapy. Pediatr Blood Cancer. 2021 10; 68(10):e29127. PMID: 34022098; PMCID: PMC8384664.
    Citations: 1     Fields:    Translation:Humans
  18. Shulman DS, Kiwinda LV, Edwards S, Clinton CM, Hunt S, Greenspan L, Lawler KD, Reaman G, Al-Sayegh H, Bona K, O'Neill AF, Shusterman S, Janeway KA, Place AE, Chi SN, Ma C, DuBois SG. Retrospective evaluation of single patient investigational new drug (IND) requests in pediatric oncology. Cancer Med. 2021 Apr; 10(7):2310-2318. PMID: 33751835; PMCID: PMC7982629.
    Citations:    Fields:    
  19. Bona K, Li Y, Winestone LE, Getz KD, Huang YS, Fisher BT, Desai AV, Richardson T, Hall M, Naranjo A, Henderson TO, Aplenc R, Bagatell R. Poverty and Targeted Immunotherapy: Survival in Children's Oncology Group Clinical Trials for High-Risk Neuroblastoma. J Natl Cancer Inst. 2021 03 01; 113(3):282-291. PMID: 33227816; PMCID: PMC7936051.
    Citations: 6     Fields:    Translation:Humans
  20. Bona K, Brazauskas R, He N, Lehmann L, Abdel-Azim H, Ahmed IA, Al-Homsi AS, Aljurf M, Arnold SD, Badawy SM, Battiwalla M, Beattie S, Bhatt NS, Dalal J, Dandoy CE, Diaz MA, Frangoul HA, Freytes CO, Ganguly S, George B, Gomez-Almaguer D, Hahn T, Kamble RT, Knight JM, LeMaistre CF, Law J, Lazarus HM, Majhail NS, Olsson RF, Preussler J, Savani BN, Schears R, Seo S, Sharma A, Srivastava A, Steinberg A, Szwajcer D, Wirk B, Yoshimi A, Khera N, Wood WA, Hashmi S, Duncan CN, Saber W. Neighborhood poverty and pediatric allogeneic hematopoietic cell transplantation outcomes: a CIBMTR analysis. Blood. 2021 01 28; 137(4):556-568. PMID: 33104215; PMCID: PMC7845011.
    Citations: 5     Fields:    Translation:Humans
  21. Bitterman DS, Bona K, Laurie F, Kao PC, Terezakis SA, London WB, Haas-Kogan DA. Race Disparities in Proton Radiotherapy Use for Cancer Treatment in Patients Enrolled in Children's Oncology Group Trials. JAMA Oncol. 2020 09 01; 6(9):1465-1468. PMID: 32910158; PMCID: PMC7411938.
    Citations: 8     Fields:    Translation:Humans
  22. Bitterman DS, Bona K, Laurie F, Kao PC, Terezakis SA, London WB, Haas-Kogan DA. Race Disparities in Proton Radiotherapy Use for Cancer Treatment in Patients Enrolled in Children's Oncology Group Trials. JAMA Oncol. 2020 Aug 06. PMID: 32761120.
    Citations:    Fields:    
  23. Lim M, Shulman DS, Roberts H, Li A, Clymer J, Bona K, Al-Sayegh H, Ma C, DuBois SG. Off-label prescribing of targeted anticancer therapy at a large pediatric cancer center. Cancer Med. 2020 09; 9(18):6658-6666. PMID: 32750219; PMCID: PMC7520353.
    Citations: 4     Fields:    Translation:Humans
  24. Lau N, Bradford MC, Steineck A, Scott S, Bona K, Yi-Frazier JP, McCauley E, Rosenberg AR. Examining key sociodemographic characteristics of adolescents and young adults with cancer: A post hoc analysis of the Promoting Resilience in Stress Management randomized clinical trial. Palliat Med. 2020 03; 34(3):336-348. PMID: 31680625; PMCID: PMC7289194.
    Citations: 4     Fields:    Translation:Humans
  25. Lau N, Yi-Frazier JP, Bona K, Baker KS, McCauley E, Rosenberg AR. Distress and resilience among adolescents and young adults with cancer and their mothers: An exploratory analysis. J Psychosoc Oncol. 2020 Jan-Feb; 38(1):118-124. PMID: 31456508; PMCID: PMC6994369.
    Citations:    Fields:    Translation:Humans
  26. Rosenberg AR, Bona K, Coker T, Feudtner C, Houston K, Ibrahim A, Macauley R, Wolfe J, Hays R. Pediatric Palliative Care in the Multicultural Context: Findings From a Workshop Conference. J Pain Symptom Manage. 2019 04; 57(4):846-855.e2. PMID: 30685496.
    Citations: 1     Fields:    Translation:Humans
  27. Ilowite MF, Al-Sayegh H, Ma C, Dussel V, Rosenberg AR, Feudtner C, Kang TI, Wolfe J, Bona K. The relationship between household income and patient-reported symptom distress and quality of life in children with advanced cancer: A report from the PediQUEST study. Cancer. 2018 10 01; 124(19):3934-3941. PMID: 30216416; PMCID: PMC6561342.
    Citations: 16     Fields:    Translation:Humans
  28. Lau N, Bona K, Steineck A, Rosenberg AR. What we did not learn from an exploratory analysis of economic hardship in newly diagnosed adolescents and young adults with cancer. Pediatr Blood Cancer. 2018 Dec; 65(12):e27411. PMID: 30155981; PMCID: PMC6193842.
    Citations: 1     Fields:    Translation:Humans
  29. Zheng DJ, Shyr D, Ma C, Muriel AC, Wolfe J, Bona K. Feasibility of systematic poverty screening in a pediatric oncology referral center. Pediatr Blood Cancer. 2018 12; 65(12):e27380. PMID: 30069999; PMCID: PMC6193823.
    Citations: 5     Fields:    Translation:Humans
  30. Scheurer ME, Lupo PJ, Schüz J, Spector LG, Wiemels JL, Aplenc R, Gramatges MM, Schiffman JD, Pombo-de-Oliveira MS, Yang JJ, Heck JE, Metayer C, Orjuela-Grimm MA, Bona K, Aristizabal P, Austin MT, Rabin KR, Russell HV, Poplack DG. An overview of disparities in childhood cancer: Report on the Inaugural Symposium on Childhood Cancer Health Disparities, Houston, Texas, 2016. Pediatr Hematol Oncol. 2018 Mar; 35(2):95-110. PMID: 29737912; PMCID: PMC6685736.
    Citations: 9     Fields:    Translation:Humans
  31. Rosenberg AR, Bradford MC, Bona K, Shaffer ML, Wolfe J, Baker KS, Lau N, Yi-Frazier J. Hope, distress, and later quality of life among adolescent and young adults with cancer. J Psychosoc Oncol. 2018 Mar-Apr; 36(2):137-144. PMID: 28934026.
    Citations: 10     Fields:    Translation:Humans
  32. Bona K, Wolfe J. Disparities in Pediatric Palliative Care: An Opportunity to Strive for Equity. Pediatrics. 2017 10; 140(4). PMID: 28963113; PMCID: PMC5613824.
    Citations: 7     Fields:    Translation:Humans
  33. Bilodeau M, Ma C, Al-Sayegh H, Wolfe J, Bona K. Household material hardship in families of children post-chemotherapy. Pediatr Blood Cancer. 2018 Jan; 65(1). PMID: 28941160.
    Citations: 12     Fields:    Translation:HumansCTClinical Trials
  34. Straehla JP, Barton KS, Yi-Frazier JP, Wharton C, Baker KS, Bona K, Wolfe J, Rosenberg AR. The Benefits and Burdens of Cancer: A Prospective Longitudinal Cohort Study of Adolescents and Young Adults. J Palliat Med. 2017 05; 20(5):494-501. PMID: 28051888.
    Citations: 7     Fields:    Translation:Humans
  35. Rosenberg AR, Bona K, Ketterl T, Wharton CM, Wolfe J, Baker KS. Intimacy, Substance Use, and Communication Needs During Cancer Therapy: A Report From the "Resilience in Adolescents and Young Adults" Study. J Adolesc Health. 2017 01; 60(1):93-99. PMID: 27769762.
    Citations: 10     Fields:    Translation:Humans
  36. Shutske K, Yi-Frazier JP, Wharton CM, Baker KS, Bona KO, Wolfe J, Rosenberg AR. The benefits and burdens of cancer: A prospective, longitudinal cohort study of adolescents and young adults. J Clin Oncol. 2016 Oct 09; 34(26_suppl):243. PMID: 28156534.
    Citations:    
  37. Abel GA, Albelda R, Khera N, Hahn T, Salas Coronado DY, Odejide OO, Bona K, Tucker-Seeley R, Soiffer R. Financial Hardship and Patient-Reported Outcomes after Hematopoietic Cell Transplantation. Biol Blood Marrow Transplant. 2016 08; 22(8):1504-1510. PMID: 27184627; PMCID: PMC4949125.
    Citations: 30     Fields:    Translation:Humans
  38. Rosenberg AR, Bona K. The Power of Personal Narrative: A Reply to "The Reality of Relapse: Impact of Cancer Relapse on Survivorship Interventions and Patient-Reported Outcomes Data". Pediatr Blood Cancer. 2016 08; 63(8):1494. PMID: 27082716.
    Citations:    Fields:    Translation:Humans
  39. Bona K, Blonquist TM, Neuberg DS, Silverman LB, Wolfe J. Impact of Socioeconomic Status on Timing of Relapse and Overall Survival for Children Treated on Dana-Farber Cancer Institute ALL Consortium Protocols (2000-2010). Pediatr Blood Cancer. 2016 Jun; 63(6):1012-8. PMID: 26913850.
    Citations: 26     Fields:    Translation:Humans
  40. Rosenberg AR, Bona K, Wharton CM, Bradford M, Shaffer ML, Wolfe J, Baker KS. Adolescent and Young Adult Patient Engagement and Participation in Survey-Based Research: A Report From the "Resilience in Adolescents and Young Adults With Cancer" Study. Pediatr Blood Cancer. 2016 Apr; 63(4):734-6. PMID: 26681427.
    Citations: 17     Fields:    Translation:Humans
  41. Pelletier W, Bona K. Assessment of Financial Burden as a Standard of Care in Pediatric Oncology. Pediatr Blood Cancer. 2015 Dec; 62 Suppl 5:S619-31. PMID: 26700920.
    Citations: 30     Fields:    Translation:Humans
  42. Bona K, London WB, Guo D, Frank DA, Wolfe J. Trajectory of Material Hardship and Income Poverty in Families of Children Undergoing Chemotherapy: A Prospective Cohort Study. Pediatr Blood Cancer. 2016 Jan; 63(1):105-11. PMID: 26398865.
    Citations: 35     Fields:    Translation:Humans
  43. Bona K, London WB, Guo D, Abel G, Lehmann L, Wolfe J. Prevalence and impact of financial hardship among New England pediatric stem cell transplantation families. Biol Blood Marrow Transplant. 2015 Feb; 21(2):312-8. PMID: 25445021.
    Citations: 18     Fields:    Translation:Humans
  44. Bona K, Dussel V, Orellana L, Kang T, Geyer R, Feudtner C, Wolfe J. Economic impact of advanced pediatric cancer on families. J Pain Symptom Manage. 2014 Mar; 47(3):594-603. PMID: 23870843.
    Citations: 50     Fields:    Translation:Humans
  45. Bona K, Bates J, Wolfe J. Massachusetts' Pediatric Palliative Care Network: successful implementation of a novel state-funded pediatric palliative care program. J Palliat Med. 2011 Nov; 14(11):1217-23. PMID: 21823906.
    Citations: 15     Fields:    Translation:Humans
  46. Dussel V, Bona K, Heath JA, Hilden JM, Weeks JC, Wolfe J. Unmeasured costs of a child's death: perceived financial burden, work disruptions, and economic coping strategies used by American and Australian families who lost children to cancer. J Clin Oncol. 2011 Mar 10; 29(8):1007-13. PMID: 21205758.
    Citations: 23     Fields:    Translation:Humans
  47. Neuner JM, Hamel MB, Phillips RS, Bona K, Aronson MD. Diagnosis and management of adults with pharyngitis. A cost-effectiveness analysis. Ann Intern Med. 2003 Jul 15; 139(2):113-22. PMID: 12859161.
    Citations: 35     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.