Assistant Professor of Pediatrics
Dana-Farber Cancer Institute
Dana-Farber Cancer Institute
450 Brookline Ave
Boston MA 02215
American Academy of Hospice and Palliative Medicine (AAHPM) Research Scholar
ASCO Young Investigator Award
St. Baldrick's Foundation Fellow
Radcliffe Exploratory Seminar Leader
The Bona Lab at Dana-Farber Cancer Institute studies outcome disparities in childhood cancer with a focus on improving childhood cancer outcomes by systematically considering social determinants of health as risk factors in the clinical trial setting and potential targets for intervention.
One in five children diagnosed with cancer in the United States lives in poverty, and we have demonstrated that poverty is associated with higher rates of relapse, decreased overall survival, and higher symptom burden even when children are treated on clinical trials at large academic medical centers. Poverty-associated outcome disparities in this context highlight the stubborn reality that increased understanding of tumor and host biology and the development of rational therapeutics may be necessary, but not sufficient, to achieve the cures we desire. Our research is based on the premise that transformative improvements in outcome are most likely to be achieved if we expand our conceptual model of discovery and intervention beyond biology to include social determinants of health outcomes at every stage in pediatric cancer research.
?The mission of the Bona Lab is to ensure that every child diagnosed with cancer has an equal chance of survival and optimal quality-of-life during and after treatment. We aim to achieve this by uniting traditional outcomes and health services research with the robust clinical trial model of discovery and care which has steadily improved outcomes for children with cancer over the last half century. Our team is highly collaborative and leverages the expertise of colleagues conducting multicenter clinical trials and basic science translational research to consider risk factors for disease outcome from a novel lens.
Available: 04/05/22, Expires: 06/01/23
My current research includes 1) clinical-trial embedded prospective investigations of poverty and outcomes (relapse, survival, late effects, utilization) in childhood ALL and neuroblastoma; 2) design and evaluation of poverty-targeted interventions for the pediatric oncology clinical setting; and 3) Collaborative translational investigation of physiological responses/chemotherapy resistance due to poverty-associated stress. My research group is broadly focused on investigating social determinants if health and outcome disparities in subspecialty pediatrics.
The research activities and funding listed below are automatically derived from
NIH ExPORTER and other sources, which might result in incorrect or missing items.
to make corrections and additions.
(ZHOU, ERIC S)
Apr 1, 2021 - Mar 31, 2023
A Preventive Care Approach to Mitigate the Impact of Pediatric ALL Treatment on Sleep
Role: Co-Principal Investigator
(BONA, KIRA O)
Sep 20, 2016 - Feb 28, 2022
Material Hardship as a Targetable Measure of Poverty in Pediatric Cancer
Role: Principal Investigator
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