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Kira O'Neil Bona, M.D.

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American Academy of Hospice and Palliative Medicine (AAHPM) Research Scholar
ASCO Young Investigator Award
St. Baldrick's Foundation Fellow

Despite advances in pediatric oncology treatment, nearly 20% of children still die of their disease, and children with cancer experience significant morbidity throughout the course of illness. Understanding the contribution of social determinants of health to pediatric cancer outcomes may provide targetable factors involved in residual morbidity and mortality. It is widely recognized that poverty is correlated with negative health outcomes, including mortality, in both pediatric primary care and chronic illness. How poverty impacts pediatric cancer outcomes is less well understood. Emerging evidence suggests that despite highly protocolized care, poverty-related outcome disparities exist in pediatric cancer. Data elucidating the mechanisms linking family poverty and childhood cancer outcomes have the potential to shift current clinical practice paradigms which rely exclusively on biological factors for risk stratification.

My current research aims to identify the relationship between household material hardship (HMH)--a modifiable domain of poverty which includes unmet concrete resource needs such as food, housing and energy security--and childhood cancer outcomes utilizing a mixed methods approach. The ultimate goal of this research is to develop poverty-targeted interventions for the clinical trial setting to improve childhood cancer outcomes.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K07CA211847 (BONA, KIRA O) Sep 20, 2016 - Aug 31, 2021
    Material Hardship as a Targetable Measure of Poverty in Pediatric Cancer
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Ilowite MF, Al-Sayegh H, Ma C, Dussel V, Rosenberg AR, Feudtner C, Kang TI, Wolfe J, Bona K. The relationship between household income and patient-reported symptom distress and quality of life in children with advanced cancer: A report from the PediQUEST study. Cancer. 2018 10 01; 124(19):3934-3941. PMID: 30216416.
    Citations:    Fields:    
  2. Lau N, Bona K, Steineck A, Rosenberg AR. What we did not learn from an exploratory analysis of economic hardship in newly diagnosed adolescents and young adults with cancer. Pediatr Blood Cancer. 2018 Dec; 65(12):e27411. PMID: 30155981.
    Citations:    Fields:    
  3. Zheng DJ, Shyr D, Ma C, Muriel AC, Wolfe J, Bona K. Feasibility of systematic poverty screening in a pediatric oncology referral center. Pediatr Blood Cancer. 2018 12; 65(12):e27380. PMID: 30069999.
    Citations:    Fields:    
  4. Scheurer ME, Lupo PJ, Schüz J, Spector LG, Wiemels JL, Aplenc R, Gramatges MM, Schiffman JD, Pombo-de-Oliveira MS, Yang JJ, Heck JE, Metayer C, Orjuela-Grimm MA, Bona K, Aristizabal P, Austin MT, Rabin KR, Russell HV, Poplack DG. An overview of disparities in childhood cancer: Report on the Inaugural Symposium on Childhood Cancer Health Disparities, Houston, Texas, 2016. Pediatr Hematol Oncol. 2018 Mar; 35(2):95-110. PMID: 29737912.
    Citations:    Fields:    Translation:Humans
  5. Rosenberg AR, Bradford MC, Bona K, Shaffer ML, Wolfe J, Baker KS, Lau N, Yi-Frazier J. Hope, distress, and later quality of life among adolescent and young adults with cancer. J Psychosoc Oncol. 2018 Mar-Apr; 36(2):137-144. PMID: 28934026.
    Citations: 2     Fields:    
  6. Bona K, Wolfe J. Disparities in Pediatric Palliative Care: An Opportunity to Strive for Equity. Pediatrics. 2017 10; 140(4). PMID: 28963113.
    Citations: 2     Fields:    Translation:Humans
  7. Bilodeau M, Ma C, Al-Sayegh H, Wolfe J, Bona K. Household material hardship in families of children post-chemotherapy. Pediatr Blood Cancer. 2018 Jan; 65(1). PMID: 28941160.
    Citations:    Fields:    Translation:HumansCTClinical Trials
  8. Straehla JP, Barton KS, Yi-Frazier JP, Wharton C, Baker KS, Bona K, Wolfe J, Rosenberg AR. The Benefits and Burdens of Cancer: A Prospective Longitudinal Cohort Study of Adolescents and Young Adults. J Palliat Med. 2017 05; 20(5):494-501. PMID: 28051888.
    Citations: 5     Fields:    Translation:Humans
  9. Rosenberg AR, Bona K, Ketterl T, Wharton CM, Wolfe J, Baker KS. Intimacy, Substance Use, and Communication Needs During Cancer Therapy: A Report From the "Resilience in Adolescents and Young Adults" Study. J Adolesc Health. 2017 01; 60(1):93-99. PMID: 27769762.
    Citations: 3     Fields:    Translation:Humans
  10. Shutske K, Yi-Frazier JP, Wharton CM, Baker KS, Bona KO, Wolfe J, Rosenberg AR. The benefits and burdens of cancer: A prospective, longitudinal cohort study of adolescents and young adults. J Clin Oncol. 2016 Oct 09; 34(26_suppl):243. PMID: 28156534.
  11. Abel GA, Albelda R, Khera N, Hahn T, Salas Coronado DY, Odejide OO, Bona K, Tucker-Seeley R, Soiffer R. Financial Hardship and Patient-Reported Outcomes after Hematopoietic Cell Transplantation. Biol Blood Marrow Transplant. 2016 08; 22(8):1504-1510. PMID: 27184627.
    Citations: 9     Fields:    Translation:Humans
  12. Rosenberg AR, Bona K. The Power of Personal Narrative: A Reply to "The Reality of Relapse: Impact of Cancer Relapse on Survivorship Interventions and Patient-Reported Outcomes Data". Pediatr Blood Cancer. 2016 08; 63(8):1494. PMID: 27082716.
    Citations:    Fields:    Translation:Humans
  13. Bona K, Blonquist TM, Neuberg DS, Silverman LB, Wolfe J. Impact of Socioeconomic Status on Timing of Relapse and Overall Survival for Children Treated on Dana-Farber Cancer Institute ALL Consortium Protocols (2000-2010). Pediatr Blood Cancer. 2016 Jun; 63(6):1012-8. PMID: 26913850.
    Citations: 9     Fields:    Translation:Humans
  14. Rosenberg AR, Bona K, Wharton CM, Bradford M, Shaffer ML, Wolfe J, Baker KS. Adolescent and Young Adult Patient Engagement and Participation in Survey-Based Research: A Report From the "Resilience in Adolescents and Young Adults With Cancer" Study. Pediatr Blood Cancer. 2016 Apr; 63(4):734-6. PMID: 26681427.
    Citations: 10     Fields:    Translation:Humans
  15. Pelletier W, Bona K. Assessment of Financial Burden as a Standard of Care in Pediatric Oncology. Pediatr Blood Cancer. 2015 Dec; 62 Suppl 5:S619-31. PMID: 26700920.
    Citations: 6     Fields:    Translation:Humans
  16. Bona K, London WB, Guo D, Frank DA, Wolfe J. Trajectory of Material Hardship and Income Poverty in Families of Children Undergoing Chemotherapy: A Prospective Cohort Study. Pediatr Blood Cancer. 2016 Jan; 63(1):105-11. PMID: 26398865.
    Citations: 5     Fields:    Translation:Humans
  17. Bona K, London WB, Guo D, Abel G, Lehmann L, Wolfe J. Prevalence and impact of financial hardship among New England pediatric stem cell transplantation families. Biol Blood Marrow Transplant. 2015 Feb; 21(2):312-8. PMID: 25445021.
    Citations: 4     Fields:    Translation:Humans
  18. Bona K, Dussel V, Orellana L, Kang T, Geyer R, Feudtner C, Wolfe J. Economic impact of advanced pediatric cancer on families. J Pain Symptom Manage. 2014 Mar; 47(3):594-603. PMID: 23870843.
    Citations: 18     Fields:    Translation:Humans
  19. Bona K, Bates J, Wolfe J. Massachusetts' Pediatric Palliative Care Network: successful implementation of a novel state-funded pediatric palliative care program. J Palliat Med. 2011 Nov; 14(11):1217-23. PMID: 21823906.
    Citations: 9     Fields:    Translation:Humans
  20. Dussel V, Bona K, Heath JA, Hilden JM, Weeks JC, Wolfe J. Unmeasured costs of a child's death: perceived financial burden, work disruptions, and economic coping strategies used by American and Australian families who lost children to cancer. J Clin Oncol. 2011 Mar 10; 29(8):1007-13. PMID: 21205758.
    Citations: 11     Fields:    Translation:Humans
  21. Neuner JM, Hamel MB, Phillips RS, Bona K, Aronson MD. Diagnosis and management of adults with pharyngitis. A cost-effectiveness analysis. Ann Intern Med. 2003 Jul 15; 139(2):113-22. PMID: 12859161.
    Citations: 18     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.