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profileE. Antonio Chiocca, M.D.,Ph.D.

TitleHarvey W. Cushing Professor of Neurosurgery
InstitutionBrigham and Women's Hospital
DepartmentNeurosurgery
AddressBrigham and Womens Hospital
Neurosurgery
75 Francis St
Boston MA 02115
Phone617/732-6939
vCardDownload vCard (login for email)
Other Positions
TitleHead of the Department of Neurosurgery at the Brigham and Women's Hospital
InstitutionBrigham and Women's Hospital
DepartmentNeurosurgery


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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Rooj AK, Ricklefs F, Mineo M, Nakano I, Chiocca EA, Bronisz A, Godlewski J. MicroRNA-Mediated Dynamic Bidirectional Shift between the Subclasses of Glioblastoma Stem-like Cells. Cell Rep. 2017 Jun 06; 19(10):2026-2032. PMID: 28591575.
    View in: PubMed
  2. Cho CF, Wolfe JM, Fadzen CM, Calligaris D, Hornburg K, Chiocca EA, Agar NYR, Pentelute BL, Lawler SE. Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents. Nat Commun. 2017 Jun 06; 8:15623. PMID: 28585535.
    View in: PubMed
  3. Lawler SE, Speranza MC, Cho CF, Chiocca EA. Oncolytic Viruses in Cancer Treatment: A Review. JAMA Oncol. 2017 Jun 01; 3(6):841-849. PMID: 27441411.
    View in: PubMed
  4. Teng J, Carla da Hora C, Kantar RS, Nakano I, Wakimoto H, Batchelor TT, Chiocca EA, Badr CE, Tannous BA. Dissecting inherent intratumor heterogeneity in patient-derived glioblastoma culture models. Neuro Oncol. 2017 Jun 01; 19(6):820-832. PMID: 28062830.
    View in: PubMed
  5. Godlewski J, Ferrer-Luna R, Rooj AK, Mineo M, Ricklefs F, Takeda YS, Nowicki MO, Salinska E, Nakano I, Lee H, Weissleder R, Beroukhim R, Chiocca EA, Bronisz A. MicroRNA Signatures and Molecular Subtypes of Glioblastoma: The Role of Extracellular Transfer. Stem Cell Reports. 2017 Jun 06; 8(6):1497-1505. PMID: 28528698.
    View in: PubMed
  6. Figueroa JM, Skog J, Akers J, Li H, Komotar R, Jensen R, Ringel F, Yang I, Kalkanis S, Thompson R, LoGuidice L, Berghoff E, Parsa A, Liau L, Curry W, Cahill D, Bettegowda C, Lang FF, Chiocca EA, Henson J, Kim R, Breakefield X, Chen C, Messer K, Hochberg F, Carter BS. Detection of wtEGFR Amplification and EGFRvIII Mutation in CSF-Derived Extracellular Vesicles of Glioblastoma Patients. Neuro Oncol. 2017 Apr 27. PMID: 28453784.
    View in: PubMed
  7. Walicke P, Abosch A, Asher A, Barker FG, Ghogawala Z, Harbaugh R, Jehi L, Kestle J, Koroshetz W, Little R, Rubin D, Valadka A, Wisniewski S, Chiocca EA. Launching Effectiveness Research to Guide Practice in Neurosurgery: A National Institute Neurological Disorders and Stroke Workshop Report. Neurosurgery. 2017 Apr 01; 80(4):505-514. PMID: 28362926.
    View in: PubMed
  8. Chiocca EA, Smith KM, McKinney B, Palmer CA, Rosenfeld S, Lillehei K, Hamilton A, DeMasters BK, Judy K, Kirn D. A Phase I Trial of Ad.hIFN-ß Gene Therapy for Glioma. Mol Ther. 2008 Mar; 16(3):618-626. PMID: 28178503.
    View in: PubMed
  9. Tannous BA, Chiocca EA, Jacobs AH, Corey DP, Breakefield XO. Tannous et al. Respond. Mol Ther. 2009 Aug; 17(8):1311-1312. PMID: 28160907.
    View in: PubMed
  10. Abou-Al-Shaar H, Abd-El-Barr MM, Zaidi HA, Russell-Goldman E, Folkerth RD, Laws ER, Chiocca EA. Frontal dermoid cyst coexisting with suprasellar craniopharyngioma: a spectrum of ectodermally derived epithelial-lined cystic lesions? Neurosurg Focus. 2016 12; 41(6):E16. PMID: 27903118.
    View in: PubMed
  11. Grauwet K, Chiocca EA. Glioma and microglia, a double entendre. Nat Immunol. 2016 Oct 19; 17(11):1240-1242. PMID: 27760107.
    View in: PubMed
  12. Hickman TT, Shuman ME, Johnson TA, Yang F, Rice RR, Rice IM, Chung EH, Wiemann R, Tinl M, Iracheta C, Chen G, Flynn P, Mondello MB, Thompson J, Meadows ME, Carroll RS, Yang HW, Xing H, Pilgrim D, Chiocca EA, Dunn IF, Golby AJ, Johnson MD. Association between shunt-responsive idiopathic normal pressure hydrocephalus and alcohol. J Neurosurg. 2016 Sep 30; 1-9. PMID: 27689463.
    View in: PubMed
  13. Mineo M, Ricklefs F, Rooj AK, Lyons SM, Ivanov P, Ansari KI, Nakano I, Chiocca EA, Godlewski J, Bronisz A. The Long Non-coding RNA HIF1A-AS2 Facilitates the Maintenance of Mesenchymal Glioblastoma Stem-like Cells in Hypoxic Niches. Cell Rep. 2016 Jun 14; 15(11):2500-9. PMID: 27264189; PMCID: PMC4909547.
  14. Cho CF, Lee K, Speranza MC, Bononi FC, Viapiano MS, Luyt LG, Weissleder R, Chiocca EA, Lee H, Lawler SE. Design of a Microfluidic Chip for Magnetic-Activated Sorting of One-Bead-One-Compound Libraries. ACS Comb Sci. 2016 06 13; 18(6):271-8. PMID: 27124678.
    View in: PubMed
  15. Chen X, Han J, Chu J, Zhang L, Zhang J, Chen C, Chen L, Wang Y, Wang H, Yi L, Elder JB, Wang QE, He X, Kaur B, Chiocca EA, Yu J. A combinational therapy of EGFR-CAR NK cells and oncolytic herpes simplex virus 1 for breast cancer brain metastases. Oncotarget. 2016 May 10; 7(19):27764-77. PMID: 27050072.
    View in: PubMed
  16. Ricklefs F, Mineo M, Rooj AK, Nakano I, Charest A, Weissleder R, Breakefield XO, Chiocca EA, Godlewski J, Bronisz A. Extracellular Vesicles from High-Grade Glioma Exchange Diverse Pro-oncogenic Signals That Maintain Intratumoral Heterogeneity. Cancer Res. 2016 May 15; 76(10):2876-81. PMID: 27013191; PMCID: PMC4873326 [Available on 05/15/17].
  17. Price RL, Harkins L, Chiocca EA, Zhang PJ, Kurt H, Iwenofu OH. Human Cytomegalovirus is Present in Alveolar Soft Part Sarcoma. Appl Immunohistochem Mol Morphol. 2016 Mar 17. PMID: 26990748.
    View in: PubMed
  18. Bronisz A, Godlewski J, Chiocca EA. Extracellular Vesicles and MicroRNAs: Their Role in Tumorigenicity and Therapy for Brain Tumors. Cell Mol Neurobiol. 2016 Apr; 36(3):361-76. PMID: 26983830.
    View in: PubMed
  19. Teplyuk NM, Uhlmann EJ, Gabriely G, Volfovsky N, Wang Y, Teng J, Karmali P, Marcusson E, Peter M, Mohan A, Kraytsberg Y, Cialic R, Chiocca EA, Godlewski J, Tannous B, Krichevsky AM. Therapeutic potential of targeting microRNA-10b in established intracranial glioblastoma: first steps toward the clinic. EMBO Mol Med. 2016 Mar 01; 8(3):268-87. PMID: 26881967; PMCID: PMC4772951.
  20. Speranza MC, Nowicki MO, Behera P, Cho CF, Chiocca EA, Lawler SE. BKM-120 (Buparlisib): A Phosphatidyl-Inositol-3 Kinase Inhibitor with Anti-Invasive Properties in Glioblastoma. Sci Rep. 2016 Feb 05; 6:20189. PMID: 26846842; PMCID: PMC4742861.
  21. Wheeler LA, Manzanera AG, Bell SD, Cavaliere R, McGregor JM, Grecula JC, Newton HB, Lo SS, Badie B, Portnow J, Teh BS, Trask TW, Baskin DS, New PZ, Aguilar LK, Aguilar-Cordova E, Chiocca EA. Phase II multicenter study of gene-mediated cytotoxic immunotherapy as adjuvant to surgical resection for newly diagnosed malignant glioma. Neuro Oncol. 2016 Aug; 18(8):1137-45. PMID: 26843484; PMCID: PMC4933478 [Available on 08/01/17].
  22. Lim M, Weller M, Chiocca EA. Current State of Immune-Based Therapies for Glioblastoma. Am Soc Clin Oncol Educ Book. 2016; 35:e132-9. PMID: 27249715.
    View in: PubMed
  23. Hulou MM, Cho CF, Chiocca EA, Bjerkvig R. Experimental therapies: gene therapies and oncolytic viruses. Handb Clin Neurol. 2016; 134:183-97. PMID: 26948355.
    View in: PubMed
  24. Peruzzi PP, Chiocca EA. Cancer immunotherapy: A vaccine from plant virus proteins. Nat Nanotechnol. 2016 Mar; 11(3):214-5. PMID: 26689377.
    View in: PubMed
  25. Han J, Chen X, Chu J, Xu B, Meisen WH, Chen L, Zhang L, Zhang J, He X, Wang QE, Chiocca EA, Kaur B, Caligiuri MA, Yu J. TGFß Treatment Enhances Glioblastoma Virotherapy by Inhibiting the Innate Immune Response. Cancer Res. 2015 Dec 15; 75(24):5273-82. PMID: 26631269.
    View in: PubMed
  26. Nakashima H, Nguyen T, Chiocca EA. Combining HDAC inhibitors with oncolytic virotherapy for cancer therapy. Oncolytic Virother. 2015; 4:183-91. PMID: 27512681; PMCID: PMC4918398.
  27. Singh M, Ricci JA, Talbot SG, Chiocca EA, Dunn IF, Caterson EJ. Reconstruction of Rare Skull Metastases Using Free Latissimus Dorsi Flap and the Role of Preoperative Embolization in Hypervascular Skull Tumors. J Craniofac Surg. 2015 Nov; 26(8):2289-92. PMID: 26501975.
    View in: PubMed
  28. Nakashima H, Kaufmann JK, Wang PY, Nguyen T, Speranza MC, Kasai K, Okemoto K, Otsuki A, Nakano I, Fernandez S, Goins WF, Grandi P, Glorioso JC, Lawler S, Cripe TP, Chiocca EA. Histone deacetylase 6 inhibition enhances oncolytic viral replication in glioma. J Clin Invest. 2015 Nov 02; 125(11):4269-80. PMID: 26524593; PMCID: PMC4639993.
  29. Hulou MM, Cote DJ, Olubiyi OI, Smith TR, Chiocca EA, Johnson MD. Awake right hemisphere brain surgery. J Clin Neurosci. 2015 Dec; 22(12):1921-7. PMID: 26279501.
    View in: PubMed
  30. Lawler SE, Chiocca EA. Oncolytic Virus-Mediated Immunotherapy: A Combinatorial Approach for Cancer Treatment. J Clin Oncol. 2015 Sep 01; 33(25):2812-4. PMID: 26215964.
    View in: PubMed
  31. Berghauser Pont LM, Balvers RK, Kloezeman JJ, Nowicki MO, van den Bossche W, Kremer A, Wakimoto H, van den Hoogen BG, Leenstra S, Dirven CM, Chiocca EA, Lawler SE, Lamfers ML. In vitro screening of clinical drugs identifies sensitizers of oncolytic viral therapy in glioblastoma stem-like cells. Gene Ther. 2015 Dec; 22(12):947-59. PMID: 26196249.
    View in: PubMed
  32. Bronisz A, Chiocca EA, Godlewski J. Response to energy depletion: miR-451/AMPK loop. Oncotarget. 2015 Jul 20; 6(20):17851-2. PMID: 26257001; PMCID: PMC4627211.
  33. Han J, Chu J, Keung Chan W, Zhang J, Wang Y, Cohen JB, Victor A, Meisen WH, Kim SH, Grandi P, Wang QE, He X, Nakano I, Chiocca EA, Glorioso JC, Kaur B, Caligiuri MA, Yu J. CAR-Engineered NK Cells Targeting Wild-Type EGFR and EGFRvIII Enhance Killing of Glioblastoma and Patient-Derived Glioblastoma Stem Cells. Sci Rep. 2015 Jul 09; 5:11483. PMID: 26155832; PMCID: PMC4496728.
  34. Rahman R, Catalano PJ, Reardon DA, Norden AD, Wen PY, Lee EQ, Nayak L, Beroukhim R, Dunn IF, Golby AJ, Johnson MD, Chiocca EA, Claus EB, Alexander BM, Arvold ND. Incidence, risk factors, and reasons for hospitalization among glioblastoma patients receiving chemoradiation. J Neurooncol. 2015 Aug; 124(1):137-46. PMID: 26033544.
    View in: PubMed
  35. Reardon DA, Ligon KL, Chiocca EA, Wen PY. One size should not fit all: advancing toward personalized glioblastoma therapy. Discov Med. 2015 Jun; 19(107):471-7. PMID: 26175405.
    View in: PubMed
  36. Forsyth TM, Bi WL, Abedalthagafi M, Dunn IF, Chiocca EA. Extracranial growth of glioblastoma multiforme. J Clin Neurosci. 2015 Sep; 22(9):1521-3. PMID: 25956620.
    View in: PubMed
  37. Bronisz A, Chiocca EA. A cross-talk network that facilitates tumor virotherapy. Nat Med. 2015 May; 21(5):426-7. PMID: 25951527.
    View in: PubMed
  38. Ansari KI, Ogawa D, Rooj AK, Lawler SE, Krichevsky AM, Johnson MD, Chiocca EA, Bronisz A, Godlewski J. Glucose-based regulation of miR-451/AMPK signaling depends on the OCT1 transcription factor. Cell Rep. 2015 May 12; 11(6):902-9. PMID: 25937278; PMCID: PMC4431904.
  39. Alvarez-Breckenridge CA, Choi BD, Suryadevara CM, Chiocca EA. Potentiating oncolytic viral therapy through an understanding of the initial immune responses to oncolytic viral infection. Curr Opin Virol. 2015 Aug; 13:25-32. PMID: 25846988.
    View in: PubMed
  40. Arvold ND, Tanguturi SK, Aizer AA, Wen PY, Reardon DA, Lee EQ, Nayak L, Christianson LW, Horvath MC, Dunn IF, Golby AJ, Johnson MD, Claus EB, Chiocca EA, Ligon KL, Alexander BM. Hypofractionated versus standard radiation therapy with or without temozolomide for older glioblastoma patients. Int J Radiat Oncol Biol Phys. 2015 Jun 01; 92(2):384-9. PMID: 25841623.
    View in: PubMed
  41. Price RL, Chiocca EA. Modeling cytomegalovirus infection in mouse tumor models. Front Oncol. 2015; 5:61. PMID: 25853089; PMCID: PMC4362273.
  42. Ramkissoon SH, Bi WL, Schumacher SE, Ramkissoon LA, Haidar S, Knoff D, Dubuc A, Brown L, Burns M, Cryan JB, Abedalthagafi M, Kang YJ, Schultz N, Reardon DA, Lee EQ, Rinne ML, Norden AD, Nayak L, Ruland S, Doherty LM, LaFrankie DC, Horvath M, Aizer AA, Russo A, Arvold ND, Claus EB, Al-Mefty O, Johnson MD, Golby AJ, Dunn IF, Chiocca EA, Trippa L, Santagata S, Folkerth RD, Kantoff P, Rollins BJ, Lindeman NI, Wen PY, Ligon AH, Beroukhim R, Alexander BM, Ligon KL. Clinical implementation of integrated whole-genome copy number and mutation profiling for glioblastoma. Neuro Oncol. 2015 Oct; 17(10):1344-55. PMID: 25754088; PMCID: PMC4578577 [Available on 10/01/16].
  43. Almefty K, Chiocca EA. The Role of Radiation Therapy in Gross Totally Resected Meningiomas. World Neurosurg. 2015 Jul; 84(1):9-11. PMID: 25731799.
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  44. Teplyuk NM, Uhlmann EJ, Wong AH, Karmali P, Basu M, Gabriely G, Jain A, Wang Y, Chiocca EA, Stephens R, Marcusson E, Yi M, Krichevsky AM. MicroRNA-10b inhibition reduces E2F1-mediated transcription and miR-15/16 activity in glioblastoma. Oncotarget. 2015 Feb 28; 6(6):3770-83. PMID: 25738367; PMCID: PMC4414152.
  45. Hulou MM, Chiocca EA. Editorial: the management of low-grade glioma in adults. Neurosurg Focus. 2015 Jan; 38(1):E8. PMID: 25599277.
    View in: PubMed
  46. Carter BS, Chiocca EA, Lonser R, Kaye AH, de Tribolet N. Introduction: a focus on low-grade glioma. Neurosurg Focus. 2015 Jan; 38(1):E2. PMID: 25552282.
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  47. Nakashima H, Nguyen T, Goins WF, Chiocca EA. Interferon-stimulated gene 15 (ISG15) and ISG15-linked proteins can associate with members of the selective autophagic process, histone deacetylase 6 (HDAC6) and SQSTM1/p62. J Biol Chem. 2015 Jan 16; 290(3):1485-95. PMID: 25429107; PMCID: PMC4340396.
  48. Godlewski J, Krichevsky AM, Johnson MD, Chiocca EA, Bronisz A. Belonging to a network--microRNAs, extracellular vesicles, and the glioblastoma microenvironment. Neuro Oncol. 2015 May; 17(5):652-62. PMID: 25301812; PMCID: PMC4482852.
  49. Wheeler LA, Chiocca EA. Predicting outcomes: recursive partitioning analysis (RPA) prognostic algorithm for patients with metastatic sarcoma to the brain. World Neurosurg. 2014 Dec; 82(6):1030-2. PMID: 25246369.
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  50. Mazzacurati L, Marzulli M, Reinhart B, Miyagawa Y, Uchida H, Goins WF, Li A, Kaur B, Caligiuri M, Cripe T, Chiocca EA, Chiocca N, Amankulor N, Cohen JB, Glorioso JC, Grandi P. Use of miRNA response sequences to block off-target replication and increase the safety of an unattenuated, glioblastoma-targeted oncolytic HSV. Mol Ther. 2015 Jan; 23(1):99-107. PMID: 25200130; PMCID: PMC4426800 [Available on 01/01/16].
  51. Reardon DA, Freeman G, Wu C, Chiocca EA, Wucherpfennig KW, Wen PY, Fritsch EF, Curry WT, Sampson JH, Dranoff G. Immunotherapy advances for glioblastoma. Neuro Oncol. 2014 Nov; 16(11):1441-58. PMID: 25190673; PMCID: PMC4201077.
  52. Dasenbrock HH, Chiocca EA. Skull base chordomas and chondrosarcomas: a population-based analysis. World Neurosurg. 2015 Apr; 83(4):468-70. PMID: 25169743.
    View in: PubMed
  53. Price RL, Chiocca EA. Evolution of malignant glioma treatment: from chemotherapy to vaccines to viruses. Neurosurgery. 2014 Aug; 61 Suppl 1:74-83. PMID: 25032534; PMCID: PMC4104417.
  54. Chiocca EA, Price RL, Hollon T, Alvarez-Breackenridge C, Fernandez S, Oglesbee M, Cook C, Lawler S, Kwon CH. Cytomegalovirus contributes to glioblastoma in the context of tumor suppressor mutations. Neuro Oncol. 2014 Jul; 16 Suppl 3:iii8. PMID: 25165375.
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  55. Ichikawa T, Onishi M, Kurozumi K, Maruo T, Inoue S, Michiue H, Yoshida K, Fuji K, Ishida J, Shimazu Y, Oka T, Chiocca EA, Date I. Annexin A2 regulates angiogenesis and invasion phenotypes of malignant glioma. Neuro Oncol. 2014 Jul; 16 Suppl 3:iii10. PMID: 25165202.
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  56. Abd-El-Barr MM, Chiocca EA. How much is enough? The question of extent of resection in glioblastoma multiforme. World Neurosurg. 2014 Jul-Aug; 82(1-2):e109-10. PMID: 24813127.
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  57. Gross BA, Chiocca EA. Low-grade gliomas and quality of life. World Neurosurg. 2014 Jul-Aug; 82(1-2):e133-4. PMID: 24813129.
    View in: PubMed
  58. Bi WL, Chiocca EA. Image-guided maximal resection of intrinsic tumors. World Neurosurg. 2014 Nov; 82(5):604-5. PMID: 24802845.
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  59. Chiocca EA, Blair D, Mufson RA. Oncolytic viruses targeting tumor stem cells. Cancer Res. 2014 Jul 01; 74(13):3396-8. PMID: 24753541.
    View in: PubMed
  60. Chiocca EA, Rabkin SD. Oncolytic viruses and their application to cancer immunotherapy. Cancer Immunol Res. 2014 Apr; 2(4):295-300. PMID: 24764576; PMCID: PMC4303349.
  61. Abd-El-Barr MM, Chiocca EA. Who benefits from surgery for brain metastases? World Neurosurg. 2014 Jul-Aug; 82(1-2):e115-6. PMID: 24636934.
    View in: PubMed
  62. Kicielinski KP, Chiocca EA, Yu JS, Gill GM, Coffey M, Markert JM. Phase 1 clinical trial of intratumoral reovirus infusion for the treatment of recurrent malignant gliomas in adults. Mol Ther. 2014 May; 22(5):1056-62. PMID: 24553100; PMCID: PMC4015229.
  63. Abd-El-Barr MM, Chiocca EA. No free lunch: secondary neoplasms after stereotactic radiation. World Neurosurg. 2015 Mar; 83(3):330-1. PMID: 24534062.
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  64. Kaufmann JK, Chiocca EA. Glioma virus therapies between bench and bedside. Neuro Oncol. 2014 Mar; 16(3):334-51. PMID: 24470549; PMCID: PMC3922526.
  65. Yan F, Alinari L, Lustberg ME, Martin LK, Cordero-Nieves HM, Banasavadi-Siddegowda Y, Virk S, Barnholtz-Sloan J, Bell EH, Wojton J, Jacob NK, Chakravarti A, Nowicki MO, Wu X, Lapalombella R, Datta J, Yu B, Gordon K, Haseley A, Patton JT, Smith PL, Ryu J, Zhang X, Mo X, Marcucci G, Nuovo G, Kwon CH, Byrd JC, Chiocca EA, Li C, Sif S, Jacob S, Lawler S, Kaur B, Baiocchi RA. Genetic validation of the protein arginine methyltransferase PRMT5 as a candidate therapeutic target in glioblastoma. Cancer Res. 2014 Mar 15; 74(6):1752-65. PMID: 24453002; PMCID: PMC3959215.
  66. Nakashima H, Chiocca EA. Modification of HSV-1 to an oncolytic virus. Methods Mol Biol. 2014; 1144:117-27. PMID: 24671680.
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  67. Bronisz A, Wang Y, Nowicki MO, Peruzzi P, Ansari KI, Ogawa D, Balaj L, De Rienzo G, Mineo M, Nakano I, Ostrowski MC, Hochberg F, Weissleder R, Lawler SE, Chiocca EA, Godlewski J. Extracellular vesicles modulate the glioblastoma microenvironment via a tumor suppression signaling network directed by miR-1. Cancer Res. 2014 Feb 01; 74(3):738-50. PMID: 24310399; PMCID: PMC3928601.
  68. Dunn IF, Chiocca EA. Academic productivity in today's training climate: a fellowship's impact. World Neurosurg. 2015 Mar; 83(3):328-9. PMID: 24176836.
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  69. Kwiatkowska A, Nandhu MS, Behera P, Chiocca EA, Viapiano MS. Strategies in gene therapy for glioblastoma. Cancers (Basel). 2013 Oct 23; 5(4):1271-305. PMID: 24202446; PMCID: PMC3875940.
  70. Nakashima H, Chiocca EA. Switching a replication-defective adenoviral vector into a replication-competent, oncolytic adenovirus. J Virol. 2014 Jan; 88(1):345-53. PMID: 24155386; PMCID: PMC3911754.
  71. Okemoto K, Kasai K, Wagner B, Haseley A, Meisen H, Bolyard C, Mo X, Wehr A, Lehman A, Fernandez S, Kaur B, Chiocca EA. DNA demethylating agents synergize with oncolytic HSV1 against malignant gliomas. Clin Cancer Res. 2013 Nov 01; 19(21):5952-9. PMID: 24056786; PMCID: PMC3860592.
  72. Bi WL, Chiocca EA. From localization to pathways: the continuing evolution of diffusion tensor imaging. World Neurosurg. 2014 Jul-Aug; 82(1-2):e47-8. PMID: 24017953.
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  73. Kaufmann JK, Chiocca EA. Oncolytic virotherapy for gliomas: steps toward the future. CNS Oncol. 2013 Sep; 2(5):389-92. PMID: 25054659.
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  74. Vengoechea J, Sloan AE, Chen Y, Guan X, Ostrom QT, Kerstetter A, Capella D, Cohen ML, Wolinsky Y, Devine K, Selman W, Barnett GH, Warnick RE, McPherson C, Chiocca EA, Elder JB, Barnholtz-Sloan JS. Methylation markers of malignant potential in meningiomas. J Neurosurg. 2013 Oct; 119(4):899-906. PMID: 23930849.
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  75. Kasai K, Nakashima H, Liu F, Kerr S, Wang J, Phelps M, Potter PM, Goins WB, Fernandez SA, Chiocca EA. Toxicology and Biodistribution Studies for MGH2.1, an Oncolytic Virus that Expresses Two Prodrug-activating Genes, in Combination with Prodrugs. Mol Ther Nucleic Acids. 2013 Aug 06; 2:e113. PMID: 23922029; PMCID: PMC3759737.
  76. Okemoto K, Wagner B, Meisen H, Haseley A, Kaur B, Chiocca EA. STAT3 activation promotes oncolytic HSV1 replication in glioma cells. PLoS One. 2013; 8(8):e71932. PMID: 23936533; PMCID: PMC3732216.
  77. Hollon TC, Price RL, Kwon CH, Chiocca EA. Mutations in glioblastoma oncosuppressive pathways pave the way for oncomodulatory activity of cytomegalovirus. Oncoimmunology. 2013 Sep 01; 2(9):e25620. PMID: 24319635.
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  78. Fujii K, Kurozumi K, Ichikawa T, Onishi M, Shimazu Y, Ishida J, Chiocca EA, Kaur B, Date I. The integrin inhibitor cilengitide enhances the anti-glioma efficacy of vasculostatin-expressing oncolytic virus. Cancer Gene Ther. 2013 Aug; 20(8):437-44. PMID: 23827879; PMCID: PMC4862362.
  79. Bi WL, Chiocca EA. Adult cerebellar glioblastomas: a distinct entity or parcel of the whole? World Neurosurg. 2013 Dec; 80(6):e181-3. PMID: 23792905.
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  80. Peruzzi P, Bronisz A, Nowicki MO, Wang Y, Ogawa D, Price R, Nakano I, Kwon CH, Hayes J, Lawler SE, Ostrowski MC, Chiocca EA, Godlewski J. MicroRNA-128 coordinately targets Polycomb Repressor Complexes in glioma stem cells. Neuro Oncol. 2013 Sep; 15(9):1212-24. PMID: 23733246; PMCID: PMC3748913.
  81. Reardon DA, Wucherpfennig KW, Freeman G, Wu CJ, Chiocca EA, Wen PY, Curry WT, Mitchell DA, Fecci PE, Sampson JH, Dranoff G. An update on vaccine therapy and other immunotherapeutic approaches for glioblastoma. Expert Rev Vaccines. 2013 Jun; 12(6):597-615. PMID: 23750791; PMCID: PMC3982399.
  82. Price RL, Song J, Bingmer K, Kim TH, Yi JY, Nowicki MO, Mo X, Hollon T, Murnan E, Alvarez-Breckenridge C, Fernandez S, Kaur B, Rivera A, Oglesbee M, Cook C, Chiocca EA, Kwon CH. Cytomegalovirus contributes to glioblastoma in the context of tumor suppressor mutations. Cancer Res. 2013 Jun 01; 73(11):3441-50. PMID: 23729642; PMCID: PMC4136413.
  83. Onishi M, Kurozumi K, Ichikawa T, Michiue H, Fujii K, Ishida J, Shimazu Y, Chiocca EA, Kaur B, Date I. Gene expression profiling of the anti-glioma effect of Cilengitide. Springerplus. 2013 Dec; 2(1):160. PMID: 23667810; PMCID: PMC3647089.
  84. Elder JB, Chiocca EA. Editorial: Glioblastoma multiforme and laser interstitial thermal therapy. J Neurosurg. 2013 Jun; 118(6):1199-200; discussion 1200-1. PMID: 23560576.
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  85. Tanabe KK, Chiocca EA. "Infectious" optimism for treatment of hepatocellular carcinoma. Mol Ther. 2013 Apr; 21(4):722-4. PMID: 23542566; PMCID: PMC3616522.
  86. Alvarez-Breckenridge CA, Yu J, Caligiuri MA, Chiocca EA. Uncovering a novel mechanism whereby NK cells interfere with glioblastoma virotherapy. Oncoimmunology. 2013 Apr 01; 2(4):e23658. PMID: 23734319.
    View in: PubMed
  87. Ikeda D, Chiocca EA. Editorial: Tumor and antiepileptic drugs: clinical article. J Neurosurg. 2013 Jun; 118(6):1181-2; discussion 1182. PMID: 23451908.
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  89. Horowitz PM, Chiocca EA. Nanotechnology-based strategies for the diagnosis and treatment of intracranial neoplasms. World Neurosurg. 2013 Jul-Aug; 80(1-2):53-5. PMID: 23416779.
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  90. Gross BA, Chiocca EA. Neoplasm development after stereotactic radiosurgery for arteriovenous malformations. World Neurosurg. 2014 Sep-Oct; 82(3-4):304-6. PMID: 23416772.
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  91. Dunn IF, Chiocca EA. Stereotactic radiosurgery and atypical meningiomas. J Neurosurg. 2013 Aug; 119(2):472-4. PMID: 23394338.
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  92. Ngwenya LB, Chiocca EA. Editorial: postoperative ischemia. J Neurosurg. 2013 Apr; 118(4):799-800; discussion 800. PMID: 23373805.
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  93. Wang PY, Currier MA, Hansford L, Kaplan D, Chiocca EA, Uchida H, Goins WF, Cohen JB, Glorioso JC, van Kuppevelt TH, Mo X, Cripe TP. Expression of HSV-1 receptors in EBV-associated lymphoproliferative disease determines susceptibility to oncolytic HSV. Gene Ther. 2013 Jul; 20(7):761-9. PMID: 23254370; PMCID: PMC3609913.
  94. Wang Y, Nowicki MO, Wang X, Arnold WD, Fernandez SA, Mo X, Wechuk J, Krisky D, Goss J, Wolfe D, Popovich PG, Lawler S, Chiocca EA. Comparative effectiveness of antinociceptive gene therapies in animal models of diabetic neuropathic pain. Gene Ther. 2013 Jul; 20(7):742-50. PMID: 23235561.
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  95. Aguilar LK, Arvizu M, Aguilar-Cordova E, Chiocca EA. The spectrum of vaccine therapies for patients with glioblastoma multiforme. Curr Treat Options Oncol. 2012 Dec; 13(4):437-50. PMID: 22903697; PMCID: PMC3499675.
  96. Alvarez-Breckenridge CA, Yu J, Price R, Wojton J, Pradarelli J, Mao H, Wei M, Wang Y, He S, Hardcastle J, Fernandez SA, Kaur B, Lawler SE, Vivier E, Mandelboim O, Moretta A, Caligiuri MA, Chiocca EA. NK cells impede glioblastoma virotherapy through NKp30 and NKp46 natural cytotoxicity receptors. Nat Med. 2012 Dec; 18(12):1827-34. PMID: 23178246; PMCID: PMC3668784.
  97. Tang CT, Kurozumi K, Pillai P, Filipce V, Chiocca EA, Ammirati M. Quantitative analysis of surgical exposure and maneuverability associated with the endoscope and the microscope in the retrosigmoid and various posterior petrosectomy approaches to the petroclival region using computer tomograpy-based frameless stereotaxy. A cadaveric study. Clin Neurol Neurosurg. 2013 Jul; 115(7):1058-62. PMID: 23177163.
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  98. Maruo T, Ichikawa T, Kanzaki H, Inoue S, Kurozumi K, Onishi M, Yoshida K, Kambara H, Ouchida M, Shimizu K, Tamaru S, Chiocca EA, Date I. Proteomics-based analysis of invasion-related proteins in malignant gliomas. Neuropathology. 2013 Jun; 33(3):264-75. PMID: 23116197.
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  99. Shaikhouni A, Chiocca EA. Editorial: glioblastoma and surgery. J Neurosurg. 2013 Apr; 118(4):809-11; discussion 810-1. PMID: 23082887.
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  100. Uchida H, Marzulli M, Nakano K, Goins WF, Chan J, Hong CS, Mazzacurati L, Yoo JY, Haseley A, Nakashima H, Baek H, Kwon H, Kumagai I, Kuroki M, Kaur B, Chiocca EA, Grandi P, Cohen JB, Glorioso JC. Effective treatment of an orthotopic xenograft model of human glioblastoma using an EGFR-retargeted oncolytic herpes simplex virus. Mol Ther. 2013 Mar; 21(3):561-9. PMID: 23070115; PMCID: PMC3589172.
  101. Price RL, Bingmer K, Harkins L, Iwenofu OH, Kwon CH, Cook C, Pelloski C, Chiocca EA. Cytomegalovirus infection leads to pleomorphic rhabdomyosarcomas in Trp53+/- mice. Cancer Res. 2012 Nov 15; 72(22):5669-74. PMID: 23002204; PMCID: PMC3500419.
  102. Onishi M, Ichikawa T, Kurozumi K, Fujii K, Yoshida K, Inoue S, Michiue H, Chiocca EA, Kaur B, Date I. Bimodal anti-glioma mechanisms of cilengitide demonstrated by novel invasive glioma models. Neuropathology. 2013 Apr; 33(2):162-74. PMID: 22989076; PMCID: PMC4861321.
  103. Shaw A, Chiocca EA. Von Hippel-Lindau disease and pregnancy. J Neurosurg. 2012 Nov; 117(5):815-6; discussion 816-7. PMID: 22937936.
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  104. Elder JB, Chiocca EA. Editorial: radiosurgery and atypical meningiomas. J Neurosurg. 2012 Oct; 117(4):676-8. PMID: 22920959.
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  105. Ngwenya LB, Chiocca EA. Editorial: meningioma and radiotherapy. J Neurosurg. 2012 Oct; 117(4):666-8. PMID: 22900842.
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  106. Gatson NN, Chiocca EA, Kaur B. Anti-angiogenic gene therapy in the treatment of malignant gliomas. Neurosci Lett. 2012 Oct 11; 527(2):62-70. PMID: 22906922; PMCID: PMC3471371.
  107. Ikeda D, Chiocca EA. Editorial: dural tail sign. J Neurosurg. 2012 Oct; 117(4):643-4. PMID: 22839655.
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  108. Shaw A, Chiocca EA. Editorial: functional neurooncology. J Neurosurg. 2012 Sep; 117(3):463-4; discussion 464-5. PMID: 22794318.
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  109. Yoo JY, Pradarelli J, Haseley A, Wojton J, Kaka A, Bratasz A, Alvarez-Breckenridge CA, Yu JG, Powell K, Mazar AP, Teknos TN, Chiocca EA, Glorioso JC, Old M, Kaur B. Copper chelation enhances antitumor efficacy and systemic delivery of oncolytic HSV. Clin Cancer Res. 2012 Sep 15; 18(18):4931-41. PMID: 22753591; PMCID: PMC3784008.
  110. Kaur B, Chiocca EA, Cripe TP. Oncolytic HSV-1 virotherapy: clinical experience and opportunities for progress. Curr Pharm Biotechnol. 2012 Jul; 13(9):1842-51. PMID: 21740359; PMCID: PMC4233127.
  111. Porensky P, Chiocca EA. Stage IV melanoma. J Neurosurg. 2012 Aug; 117(2):225-6; discussion 226. PMID: 22702483.
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  112. Ngwenya LB, Chiocca EA. Do meningioma patients benefit from antiepileptic drug treatment? World Neurosurg. 2013 Mar-Apr; 79(3-4):433-4. PMID: 22634463.
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  113. Elder JB, Chiocca EA. Convection-enhanced delivery. J Neurosurg. 2012 Aug; 117(2):193-5; discussion 195-6. PMID: 22606985.
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  114. Ngwenya LB, Chiocca EA. Treatment for paragangliomas: passing the test of time. World Neurosurg. 2012 May-Jun; 77(5-6):639-41. PMID: 22818170.
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  115. Crowley RW, Asthagiri AR, Starke RM, Zusman EE, Chiocca EA, Lonser RR. In-training factors predictive of choosing and sustaining a productive academic career path in neurological surgery. Neurosurgery. 2012 Apr; 70(4):1024-32. PMID: 21946503.
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  116. Ostrom QT, McCulloh C, Chen Y, Devine K, Wolinsky Y, Davitkov P, Robbins S, Cherukuri R, Patel A, Gupta R, Cohen M, Vengoechea Barrios J, Brewer C, Schilero C, Smolenski K, McGraw M, Denk B, Naska T, Laube F, Steele R, Greene D, Kastl A, Bell S, Aziz D, Chiocca EA, McPherson C, Warnick R, Barnett GH, Sloan AE, Barnholtz-Sloan JS. Family history of cancer in benign brain tumor subtypes versus gliomas. Front Oncol. 2012; 2:19. PMID: 22649779; PMCID: PMC3355899.
  117. Alvarez-Breckenridge CA, Yu J, Price R, Wei M, Wang Y, Nowicki MO, Ha YP, Bergin S, Hwang C, Fernandez SA, Kaur B, Caligiuri MA, Chiocca EA. The histone deacetylase inhibitor valproic acid lessens NK cell action against oncolytic virus-infected glioblastoma cells by inhibition of STAT5/T-BET signaling and generation of gamma interferon. J Virol. 2012 Apr; 86(8):4566-77. PMID: 22318143; PMCID: PMC3318659.
  118. Patel V, Rink C, Gordillo GM, Khanna S, Gnyawali U, Roy S, Shneker B, Ganesh K, Phillips G, More JL, Sarkar A, Kirkpatrick R, Elkhammas EA, Klatte E, Miller M, Firstenberg MS, Chiocca EA, Nesaretnam K, Sen CK. Oral tocotrienols are transported to human tissues and delay the progression of the model for end-stage liver disease score in patients. J Nutr. 2012 Mar; 142(3):513-9. PMID: 22298568; PMCID: PMC3278267.
  119. Powers CJ, Chiocca EA. Editorial: urinary tract infection. J Neurosurg. 2012 Apr; 116(4):909; discussion 910. PMID: 22224791.
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  120. Ikeda D, Chiocca EA. Perioperative mortality. J Neurosurg. 2012 Apr; 116(4):821-2; discussion 822-4. PMID: 22224792.
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  121. Mohyeldin A, Chiocca EA. Gene and viral therapy for glioblastoma: a review of clinical trials and future directions. Cancer J. 2012 Jan-Feb; 18(1):82-8. PMID: 22290261.
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  122. Bronisz A, Godlewski J, Wallace JA, Merchant AS, Nowicki MO, Mathsyaraja H, Srinivasan R, Trimboli AJ, Martin CK, Li F, Yu L, Fernandez SA, Pécot T, Rosol TJ, Cory S, Hallett M, Park M, Piper MG, Marsh CB, Yee LD, Jimenez RE, Nuovo G, Lawler SE, Chiocca EA, Leone G, Ostrowski MC. Reprogramming of the tumour microenvironment by stromal PTEN-regulated miR-320. Nat Cell Biol. 2011 Dec 18; 14(2):159-67. PMID: 22179046; PMCID: PMC3271169.
  123. Alvarez-Breckenridge CA, Yu J, Kaur B, Caligiuri MA, Chiocca EA. Deciphering the Multifaceted Relationship between Oncolytic Viruses and Natural Killer Cells. Adv Virol. 2012; 2012:702839. PMID: 22312364; PMCID: PMC3263705.
  124. Peruzzi P, Chiocca EA. Bringing the endovascular neurosurgeon into the neuro-oncology treatment team. World Neurosurg. 2012 Jan; 77(1):59-61. PMID: 22405385.
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  125. Inoue S, Ichikawa T, Kurozumi K, Maruo T, Onishi M, Yoshida K, Fujii K, Kambara H, Chiocca EA, Date I. Novel animal glioma models that separately exhibit two different invasive and angiogenic phenotypes of human glioblastomas. World Neurosurg. 2012 Dec; 78(6):670-82. PMID: 22120277.
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  126. Elder JB, Chiocca EA. Meningioma-toward an improved understanding of the role of sex steroids in tumor development and progression. World Neurosurg. 2011 Nov; 76(5):409-11. PMID: 22152567.
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  127. Nakano I, Chiocca EA. Hope and challenges for dendritic cell-based vaccine therapy for glioblastoma. World Neurosurg. 2012 May-Jun; 77(5-6):633-5. PMID: 22120228.
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  128. Elder JB, Chiocca EA. Molecular and genetic characterization of meningiomas: future predictive assays and "personalized" treatment. World Neurosurg. 2013 Feb; 79(2):247-8. PMID: 22120235.
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  129. Peruzzi P, Chiocca EA. Understanding glioma invasion: a necessity for effective therapy. World Neurosurg. 2013 Sep-Oct; 80(3-4):281-3. PMID: 22120237.
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  130. Yoo JY, Haseley A, Bratasz A, Chiocca EA, Zhang J, Powell K, Kaur B. Antitumor efficacy of 34.5ENVE: a transcriptionally retargeted and "Vstat120"-expressing oncolytic virus. Mol Ther. 2012 Feb; 20(2):287-97. PMID: 22031239; PMCID: PMC3277242.
  131. Powers CJ, Chiocca EA. Stroke and heart disease: the "also-rans" of radiation exposure. World Neurosurg. 2011 Sep-Oct; 76(3-4):216. PMID: 21986408.
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  132. Agudelo-Garcia PA, De Jesus JK, Williams SP, Nowicki MO, Chiocca EA, Liyanarachchi S, Li PK, Lannutti JJ, Johnson JK, Lawler SE, Viapiano MS. Glioma cell migration on three-dimensional nanofiber scaffolds is regulated by substrate topography and abolished by inhibition of STAT3 signaling. Neoplasia. 2011 Sep; 13(9):831-40. PMID: 21969816; PMCID: PMC3182275.
  133. Porensky P, Chiocca EA. Performing Quality Research in an Era of Reforms. Neurosurgery. 2011 Sep 01; 58(CN_suppl_1):72-78. PMID: 28173128.
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  134. Makary M, Chiocca EA, Erminy N, Antor M, Bergese SD, Abdel-Rasoul M, Fernandez S, Dzwonczyk R. Clinical and economic outcomes of low-field intraoperative MRI-guided tumor resection neurosurgery. J Magn Reson Imaging. 2011 Nov; 34(5):1022-30. PMID: 22002753.
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  135. Chiocca EA, Aguilar LK, Bell SD, Kaur B, Hardcastle J, Cavaliere R, McGregor J, Lo S, Ray-Chaudhuri A, Chakravarti A, Grecula J, Newton H, Harris KS, Grossman RG, Trask TW, Baskin DS, Monterroso C, Manzanera AG, Aguilar-Cordova E, New PZ. Phase IB study of gene-mediated cytotoxic immunotherapy adjuvant to up-front surgery and intensive timing radiation for malignant glioma. J Clin Oncol. 2011 Sep 20; 29(27):3611-9. PMID: 21844505; PMCID: PMC3179270.
  136. Porensky P, Chiocca EA. Use of 5-aminolevulinic acid for visualization of low-grade gliomas. J Neurosurg. 2011 Oct; 115(4):737-8; discussion 738-9. PMID: 21761974.
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  137. Alvarez-Breckenridge C, Chiocca EA. A viral strategy to ambush tumors. Nat Med. 2011 Jul 07; 17(7):784-5. PMID: 21738155; PMCID: PMC4256679.
  138. Shaw A, Chiocca EA. Neoplastic meningitis. J Neurosurg. 2011 Oct; 115(4):728-9; discussion 729. PMID: 21721876.
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  139. Peruzzi P, Chiocca EA. Prognosis and treatment of melanoma metastases to the central nervous system: lots of retrospective data, very few certainties. World Neurosurg. 2011 Jul-Aug; 76(1-2):48-50. PMID: 21839942.
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  140. Williams SP, Nowicki MO, Liu F, Press R, Godlewski J, Abdel-Rasoul M, Kaur B, Fernandez SA, Chiocca EA, Lawler SE. Indirubins decrease glioma invasion by blocking migratory phenotypes in both the tumor and stromal endothelial cell compartments. Cancer Res. 2011 Aug 15; 71(16):5374-80. PMID: 21697283; PMCID: PMC4288480.
  141. Elder JB, Chiocca EA. Low Karnofsky Performance Scale score and glioblastoma multiforme. J Neurosurg. 2011 Aug; 115(2):217-8; discussion 218-9. PMID: 21548743.
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  142. Brem SS, Bierman PJ, Brem H, Butowski N, Chamberlain MC, Chiocca EA, DeAngelis LM, Fenstermaker RA, Friedman A, Gilbert MR, Hesser D, Junck L, Linette GP, Loeffler JS, Maor MH, Michael M, Moots PL, Morrison T, Mrugala M, Nabors LB, Newton HB, Portnow J, Raizer JJ, Recht L, Shrieve DC, Sills AK, Vrionis FD, Wen PY. Central nervous system cancers. J Natl Compr Canc Netw. 2011 Apr; 9(4):352-400. PMID: 21464144.
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  143. Ikeda D, Chiocca EA. Measuring versus seeing. J Neurosurg. 2011 Jul; 115(1):9-10; discussion 10. PMID: 21438652.
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  144. Ngwenya LB, Chiocca EA. Extent of resection. J Neurosurg. 2011 Jul; 115(1):1-2; discussion 2. PMID: 21417711.
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  145. Porensky P, Chiocca EA. Preoperative comorbidity scores and intangible neurosurgical wisdom. World Neurosurg. 2011 Feb; 75(2):215-6. PMID: 21492718.
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  146. Peruzzi P, Puente E, Bergese S, Chiocca EA. Intraoperative MRI (ioMRI) in the setting of awake craniotomies for supratentorial glioma resection. Acta Neurochir Suppl. 2011; 109:43-8. PMID: 20960319.
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  147. Porensky P, Chiocca EA. Performing quality research in an era of reforms. Clin Neurosurg. 2011; 58:72-8. PMID: 21916130.
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  148. Dmitrieva N, Yu L, Viapiano M, Cripe TP, Chiocca EA, Glorioso JC, Kaur B. Chondroitinase ABC I-mediated enhancement of oncolytic virus spread and antitumor efficacy. Clin Cancer Res. 2011 Mar 15; 17(6):1362-72. PMID: 21177410; PMCID: PMC3140790.
  149. Nakano I, Chiocca EA. Finding drugs against CD133+ glioma subpopulations. J Neurosurg. 2011 Mar; 114(3):648; discussion 648-50. PMID: 21054138.
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  150. Asadi-Moghaddam K, Chiocca EA, Lawler SE. Potential role of miRNAs and their inhibitors in glioma treatment. Expert Rev Anticancer Ther. 2010 Nov; 10(11):1753-62. PMID: 21080802.
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  151. Kahn J, Loeffler JS, Niemierko A, Chiocca EA, Batchelor T, Chakravarti A. Long-term outcomes of patients with spinal cord gliomas treated by modern conformal radiation techniques. Int J Radiat Oncol Biol Phys. 2011 Sep 01; 81(1):232-8. PMID: 20947265.
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  152. Sarkar A, Chiocca EA. Multiple craniotomies. J Neurosurg. 2011 Mar; 114(3):574-5; discussion 575. PMID: 20690812.
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  153. Chiocca EA. Neurosurgical "pearls" and neurosurgical evidence. J Neurosurg. 2010 Aug; 113(2):179; discussion 179-80. PMID: 20035573.
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  154. Peruzzi P, Chiocca EA. Treating glioblastoma multiforme with electrical fields. World Neurosurg. 2010 Aug-Sep; 74(2-3):208-11. PMID: 21492532.
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  155. Chiocca EA. Monoclonal antibodies. J Neurosurg. 2010 Aug; 113(2):190; discussion 190-1. PMID: 20345220.
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  156. Elder JB, Chiocca EA. Meningioma surgery. J Neurosurg. 2011 Mar; 114(3):695; discussion 696. PMID: 20653394.
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  157. Godlewski J, Bronisz A, Nowicki MO, Chiocca EA, Lawler S. microRNA-451: A conditional switch controlling glioma cell proliferation and migration. Cell Cycle. 2010 Jul 15; 9(14):2742-8. PMID: 20647762.
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  158. Peruzzi P, Bergese SD, Viloria A, Puente EG, Abdel-Rasoul M, Chiocca EA. A retrospective cohort-matched comparison of conscious sedation versus general anesthesia for supratentorial glioma resection. Clinical article. J Neurosurg. 2011 Mar; 114(3):633-9. PMID: 20560720; PMCID: PMC4256674.
  159. Chiocca EA, Lawler SE. The many functions of microRNAs in glioblastoma. World Neurosurg. 2010 Jun; 73(6):598-601. PMID: 20934132.
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  160. Godlewski J, Nowicki MO, Bronisz A, Nuovo G, Palatini J, De Lay M, Van Brocklyn J, Ostrowski MC, Chiocca EA, Lawler SE. MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells. Mol Cell. 2010 Mar 12; 37(5):620-32. PMID: 20227367; PMCID: PMC3125113.
  161. Nakashima H, Kaur B, Chiocca EA. Directing systemic oncolytic viral delivery to tumors via carrier cells. Cytokine Growth Factor Rev. 2010 Apr-Jun; 21(2-3):119-26. PMID: 20226717; PMCID: PMC3109423.
  162. Schwartzbaum JA, Huang K, Lawler S, Ding B, Yu J, Chiocca EA. Allergy and inflammatory transcriptome is predominantly negatively correlated with CD133 expression in glioblastoma. Neuro Oncol. 2010 Apr; 12(4):320-7. PMID: 20308310; PMCID: PMC2940608.
  163. Kefas B, Comeau L, Floyd DH, Seleverstov O, Godlewski J, Schmittgen T, Jiang J, diPierro CG, Li Y, Chiocca EA, Lee J, Fine H, Abounader R, Lawler S, Purow B. The neuronal microRNA miR-326 acts in a feedback loop with notch and has therapeutic potential against brain tumors. J Neurosci. 2009 Dec 02; 29(48):15161-8. PMID: 19955368; PMCID: PMC2823067.
  164. Johnson J, Nowicki MO, Lee CH, Chiocca EA, Viapiano MS, Lawler SE, Lannutti JJ. Quantitative analysis of complex glioma cell migration on electrospun polycaprolactone using time-lapse microscopy. Tissue Eng Part C Methods. 2009 Dec; 15(4):531-40. PMID: 19199562; PMCID: PMC3497888.
  165. Hardcastle J, Kurozumi K, Dmitrieva N, Sayers MP, Ahmad S, Waterman P, Weissleder R, Chiocca EA, Kaur B. Enhanced antitumor efficacy of vasculostatin (Vstat120) expressing oncolytic HSV-1. Mol Ther. 2010 Feb; 18(2):285-94. PMID: 19844198; PMCID: PMC2818668.
  166. Kaur B, Cripe TP, Chiocca EA. "Buy one get one free": armed viruses for the treatment of cancer cells and their microenvironment. Curr Gene Ther. 2009 Oct; 9(5):341-55. PMID: 19860649; PMCID: PMC2802461.
  167. Barua E, Johnston J, Fujii J, Dzwonczyk R, Chiocca E, Bergese S. Anesthesia for brain tumor resection using intraoperative magnetic resonance imaging (iMRI) with the Polestar N-20 system: experience and challenges. J Clin Anesth. 2009 Aug; 21(5):371-6. PMID: 19700282.
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  168. Peruzzi P, Ray-Chaudhuri A, Slone WH, Mekhjian HS, Porcu P, Chiocca E. Reversal of neurological deficit after chemotherapy in BCL-6-positive neurolymphomatosis. Case report. J Neurosurg. 2009 Aug; 111(2):247-51. PMID: 19216652.
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  169. Elsheikh B, Kissel JT, Christoforidis G, Wicklund M, Kehagias DT, Chiocca EA, Mendell JR. Spinal angiography and epidural venography in juvenile muscular atrophy of the distal arm "Hirayama disease". Muscle Nerve. 2009 Aug; 40(2):206-12. PMID: 19609908.
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  170. Hirschl RA, Wilson J, Miller B, Bergese S, Chiocca E. The predictive value of low-field strength magnetic resonance imaging for intraoperative residual tumor detection. Clinical article. J Neurosurg. 2009 Aug; 111(2):252-7. PMID: 19199455.
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  171. Kim Y, Lawler S, Nowicki MO, Chiocca EA, Friedman A. A mathematical model for pattern formation of glioma cells outside the tumor spheroid core. J Theor Biol. 2009 Oct 07; 260(3):359-71. PMID: 19596356.
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  172. Alvarez-Breckenridge C, Kaur B, Chiocca EA. Pharmacologic and chemical adjuvants in tumor virotherapy. Chem Rev. 2009 Jul; 109(7):3125-40. PMID: 19462957; PMCID: PMC2790404.
  173. Asadi-Moghaddam K, Chiocca EA. Gene- and viral-based therapies for brain tumors. Neurotherapeutics. 2009 Jul; 6(3):547-57. PMID: 19560744; PMCID: PMC3052738.
  174. Tanaka S, Shaikh IM, Chiocca EA, Saeki Y. The Gs-linked receptor GPR3 inhibits the proliferation of cerebellar granule cells during postnatal development. PLoS One. 2009 Jun 15; 4(6):e5922. PMID: 19526062; PMCID: PMC2691605.
  175. Godlewski J, Newton HB, Chiocca EA, Lawler SE. MicroRNAs and glioblastoma; the stem cell connection. Cell Death Differ. 2010 Feb; 17(2):221-8. PMID: 19521422.
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  176. Patel TR, Chiocca EA, Freimer ML, Christoforidis GA. Lack of epidural pressure change with neck flexion in a patient with Hirayama disease: case report. Neurosurgery. 2009 Jun; 64(6):E1196-7; discussion E1197. PMID: 19487864.
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  177. Lawler S, Chiocca EA. Emerging functions of microRNAs in glioblastoma. J Neurooncol. 2009 May; 92(3):297-306. PMID: 19357957.
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  178. Peruzzi PP, Lawler SE, Senior SL, Dmitrieva N, Edser PA, Gianni D, Chiocca EA, Wade-Martins R. Physiological transgene regulation and functional complementation of a neurological disease gene deficiency in neurons. Mol Ther. 2009 Sep; 17(9):1517-26. PMID: 19352323; PMCID: PMC2835262.
  179. Grandi P, Peruzzi P, Reinhart B, Cohen JB, Chiocca EA, Glorioso JC. Design and application of oncolytic HSV vectors for glioblastoma therapy. Expert Rev Neurother. 2009 Apr; 9(4):505-17. PMID: 19344302; PMCID: PMC3219506.
  180. Suzuki M, Kasai K, Ohtsuki A, Godlewski J, Nowicki MO, Chiocca EA, Saeki Y. ICP0 inhibits the decrease of HSV amplicon-mediated transgene expression. Mol Ther. 2009 Apr; 17(4):707-15. PMID: 19223864; PMCID: PMC2835108.
  181. Aghi MK, Chiocca EA. Phase ib trial of oncolytic herpes virus G207 shows safety of multiple injections and documents viral replication. Mol Ther. 2009 Jan; 17(1):8-9. PMID: 19116635; PMCID: PMC2834994.
  182. Godlewski J, Nowicki MO, Bronisz A, Williams S, Otsuki A, Nuovo G, Raychaudhury A, Newton HB, Chiocca EA, Lawler S. Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal. Cancer Res. 2008 Nov 15; 68(22):9125-30. PMID: 19010882.
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  183. Tian JP, Friedman A, Wang J, Chiocca EA. Modeling the effects of resection, radiation and chemotherapy in glioblastoma. J Neurooncol. 2009 Feb; 91(3):287-93. PMID: 18836688.
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  184. Suzuki M, Chiocca EA, Saeki Y. Stable transgene expression from HSV amplicon vectors in the brain: potential involvement of immunoregulatory signals. Mol Ther. 2008 Oct; 16(10):1727-36. PMID: 18728642.
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  185. Nowicki MO, Dmitrieva N, Stein AM, Cutter JL, Godlewski J, Saeki Y, Nita M, Berens ME, Sander LM, Newton HB, Chiocca EA, Lawler S. Lithium inhibits invasion of glioma cells; possible involvement of glycogen synthase kinase-3. Neuro Oncol. 2008 Oct; 10(5):690-9. PMID: 18715951; PMCID: PMC2666245.
  186. Otsuki A, Patel A, Kasai K, Suzuki M, Kurozumi K, Chiocca EA, Saeki Y. Histone deacetylase inhibitors augment antitumor efficacy of herpes-based oncolytic viruses. Mol Ther. 2008 Sep; 16(9):1546-55. PMID: 18648350.
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  187. Kurozumi K, Hardcastle J, Thakur R, Shroll J, Nowicki M, Otsuki A, Chiocca EA, Kaur B. Oncolytic HSV-1 infection of tumors induces angiogenesis and upregulates CYR61. Mol Ther. 2008 Aug; 16(8):1382-91. PMID: 18545226; PMCID: PMC2659780.
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  199. Stein AM, Nowicki MO, Demuth T, Berens ME, Lawler SE, Chiocca EA, Sander LM. Estimating the cell density and invasive radius of three-dimensional glioblastoma tumor spheroids grown in vitro. Appl Opt. 2007 Aug 01; 46(22):5110-8. PMID: 17676121.
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  200. Dang D, Baig MN, Christoforidis G, Chiocca EA, Gabriel J. C2/C3 pathologic fractures from polyostotic fibrous dysplasia of the cervical spine treated with percutaneous vertebroplasty. Eur Spine J. 2007 Dec; 16 Suppl 3:250-4. PMID: 17665224; PMCID: PMC2148099.
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  202. Chiocca EA, Schwartzbaum JA. Gliomas and venous thromboembolism: how common? J Neurosurg. 2007 Apr; 106(4):599-600; discussion 600. PMID: 17432709.
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  222. Lamfers ML, Gianni D, Tung CH, Idema S, Schagen FH, Carette JE, Quax PH, Van Beusechem VW, Vandertop WP, Dirven CM, Chiocca EA, Gerritsen WR. Tissue inhibitor of metalloproteinase-3 expression from an oncolytic adenovirus inhibits matrix metalloproteinase activity in vivo without affecting antitumor efficacy in malignant glioma. Cancer Res. 2005 Oct 15; 65(20):9398-405. PMID: 16230403.
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  226. Zerris VA, Donoghue JD, Hochberg LR, O'Rourke DK, Chiocca EA. 885 Braingate: Turning Thought into Action-First Experience with a Human Neuromotor Prosthesis. Neurosurgery. 2005 Aug 01; 57(2):425. PMID: 28184816.
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  228. Kambara H, Okano H, Chiocca EA, Saeki Y. An oncolytic HSV-1 mutant expressing ICP34.5 under control of a nestin promoter increases survival of animals even when symptomatic from a brain tumor. Cancer Res. 2005 Apr 01; 65(7):2832-9. PMID: 15805284.
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  232. Inoue R, Moghaddam KA, Ranasinghe M, Saeki Y, Chiocca EA, Wade-Martins R. Infectious delivery of the 132 kb CDKN2A/CDKN2B genomic DNA region results in correctly spliced gene expression and growth suppression in glioma cells. Gene Ther. 2004 Aug; 11(15):1195-204. PMID: 15164098.
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  234. Post DE, Fulci G, Chiocca EA, Van Meir EG. Replicative oncolytic herpes simplex viruses in combination cancer therapies. Curr Gene Ther. 2004 Mar; 4(1):41-51. PMID: 15032613.
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  236. Chiocca EA, Waxman DJ. Cytochrome p450-based gene therapies for cancer. Methods Mol Med. 2004; 90:203-22. PMID: 14657565.
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  241. Packard SD, Mandeville JB, Ichikawa T, Ikeda K, Terada K, Niloff S, Chiocca EA, Rosen BR, Marota JJ. Functional response of tumor vasculature to PaCO2: determination of total and microvascular blood volume by MRI. Neoplasia. 2003 Jul-Aug; 5(4):330-8. PMID: 14511404; PMCID: PMC1502420.
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  243. Abe T, Terada K, Wakimoto H, Inoue R, Tyminski E, Bookstein R, Basilion JP, Chiocca EA. PTEN decreases in vivo vascularization of experimental gliomas in spite of proangiogenic stimuli. Cancer Res. 2003 May 01; 63(9):2300-5. PMID: 12727853.
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  244. Fulci G, Chiocca EA. Oncolytic viruses for the therapy of brain tumors and other solid malignancies: a review. Front Biosci. 2003 May 01; 8:e346-60. PMID: 12700108.
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  246. Wade-Martins R, Saeki Y, Chiocca EA. Infectious delivery of a 135-kb LDLR genomic locus leads to regulated complementation of low-density lipoprotein receptor deficiency in human cells. Mol Ther. 2003 May; 7(5 Pt 1):604-12. PMID: 12718903.
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  247. Hampl JA, Camp SM, Mydlarz WK, Hampl M, Ichikawa T, Chiocca EA, Louis DN, Sena-Esteves M, Breakefield XO. Potentiated gene delivery to tumors using herpes simplex virus/Epstein-Barr virus/RV tribrid amplicon vectors. Hum Gene Ther. 2003 May 01; 14(7):611-26. PMID: 12804144.
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  253. Pawlik TM, Nakamura H, Mullen JT, Kasuya H, Yoon SS, Chandrasekhar S, Chiocca EA, Tanabe KK. Prodrug bioactivation and oncolysis of diffuse liver metastases by a herpes simplex virus 1 mutant that expresses the CYP2B1 transgene. Cancer. 2002 Sep 01; 95(5):1171-81. PMID: 12209705.
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  254. Nakamura H, Kasuya H, Mullen JT, Yoon SS, Pawlik TM, Chandrasekhar S, Donahue JM, Chiocca EA, Chung RY, Tanabe KK. Regulation of herpes simplex virus gamma(1)34.5 expression and oncolysis of diffuse liver metastases by Myb34.5. J Clin Invest. 2002 Apr; 109(7):871-82. PMID: 11927614; PMCID: PMC150923.
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  258. Smith ER, Ott M, Wain J, Louis DN, Chiocca EA. Massive growth of a meningioma into the brachial plexus and thoracic cavity after intraspinal and supraclavicular resection. Case report and review of the literature. J Neurosurg. 2002 Jan; 96(1 Suppl):107-11. PMID: 11795697.
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  263. Jacobs A, Tjuvajev JG, Dubrovin M, Akhurst T, Balatoni J, Beattie B, Joshi R, Finn R, Larson SM, Herrlinger U, Pechan PA, Chiocca EA, Breakefield XO, Blasberg RG. Positron emission tomography-based imaging of transgene expression mediated by replication-conditional, oncolytic herpes simplex virus type 1 mutant vectors in vivo. Cancer Res. 2001 Apr 01; 61(7):2983-95. PMID: 11306477.
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  264. Ichikawa T, Petros WP, Ludeman SM, Fangmeier J, Hochberg FH, Colvin OM, Chiocca EA. Intraneoplastic polymer-based delivery of cyclophosphamide for intratumoral bioconversion by a replicating oncolytic viral vector. Cancer Res. 2001 Feb 01; 61(3):864-8. PMID: 11221871.
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  278. Yoon SS, Nakamura H, Carroll NM, Bode BP, Chiocca EA, Tanabe KK. An oncolytic herpes simplex virus type 1 selectively destroys diffuse liver metastases from colon carcinoma. FASEB J. 2000 Feb; 14(2):301-11. PMID: 10657986.
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  279. Quiñones-Hinojosa A, Friedlander RM, Boyer PJ, Batchelor TT, Chiocca EA. Solitary sciatic nerve lymphoma as an initial manifestation of diffuse neurolymphomatosis. Case report and review of the literature. J Neurosurg. 2000 Jan; 92(1):165-9. PMID: 10616097.
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  280. Sena-Esteves M, Saeki Y, Camp SM, Chiocca EA, Breakefield XO. Single-step conversion of cells to retrovirus vector producers with herpes simplex virus-Epstein-Barr virus hybrid amplicons. J Virol. 1999 Dec; 73(12):10426-39. PMID: 10559361; PMCID: PMC113098.
  281. Chung RY, Saeki Y, Chiocca EA. B-myb promoter retargeting of herpes simplex virus gamma34.5 gene-mediated virulence toward tumor and cycling cells. J Virol. 1999 Sep; 73(9):7556-64. PMID: 10438845; PMCID: PMC104282.
  282. Aghi M, Chou TC, Suling K, Breakefield XO, Chiocca EA. Multimodal cancer treatment mediated by a replicating oncolytic virus that delivers the oxazaphosphorine/rat cytochrome P450 2B1 and ganciclovir/herpes simplex virus thymidine kinase gene therapies. Cancer Res. 1999 Aug 15; 59(16):3861-5. PMID: 10463570.
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  283. Ikeda K, Ichikawa T, Wakimoto H, Silver JS, Deisboeck TS, Finkelstein D, Harsh GR, Louis DN, Bartus RT, Hochberg FH, Chiocca EA. Oncolytic virus therapy of multiple tumors in the brain requires suppression of innate and elicited antiviral responses. Nat Med. 1999 Aug; 5(8):881-7. PMID: 10426310.
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  284. Ikeda K, Saeki Y, Gonzalez-Agosti C, Ramesh V, Chiocca EA. Inhibition of NF2-negative and NF2-positive primary human meningioma cell proliferation by overexpression of merlin due to vector-mediated gene transfer. J Neurosurg. 1999 Jul; 91(1):85-92. PMID: 10389885.
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  285. Neuwelt EA, Abbott NJ, Drewes L, Smith QR, Couraud PO, Chiocca EA, Audus KL, Greig NH, Doolittle ND. Cerebrovascular Biology and the various neural barriers: challenges and future directions. Neurosurgery. 1999 Mar; 44(3):604-8; discussion 608-9. PMID: 10069598.
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  286. Rainov NG, Ikeda K, Qureshi NH, Grover S, Herrlinger U, Pechan P, Chiocca EA, Breakefield XO, Barnett FH. Intraarterial delivery of adenovirus vectors and liposome-DNA complexes to experimental brain neoplasms. Hum Gene Ther. 1999 Jan 20; 10(2):311-8. PMID: 10022555.
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  287. Carter BS, Zervas NT, Chiocca EA. Neurogenetic surgery: current limitations and the promise of gene- and virus-based therapies. Clin Neurosurg. 1999; 45:226-46. PMID: 10461522.
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  288. Yoon SS, Carroll NM, Chiocca EA, Tanabe KK. Influence of p53 on herpes simplex virus type 1 vectors for cancer gene therapy. J Gastrointest Surg. 1999 Jan-Feb; 3(1):34-48. PMID: 10457321.
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  289. Qureshi NH, Chiocca EA. A review of gene therapy for the treatment of central nervous system tumors. Crit Rev Oncog. 1999; 10(4):261-74. PMID: 10654926.
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  290. Rainov NG, Ikeda K, Qureshi N, Grover S, Barnett FH, Herrlinger U, Quinones A, Chiocca EA, Breakefield XO. Intra-arterial virus and nonvirus vector-mediated gene transfer to experimental rat brain tumors. Front Radiat Ther Oncol. 1999; 33:227-40. PMID: 10549492.
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  291. Barnett FH, Rainov NG, Ikeda K, Schuback DE, Elliott P, Kramm CM, Chase M, Qureshi NH, Harsh G, Chiocca EA, Breakefield XO. Selective delivery of herpes virus vectors to experimental brain tumors using RMP-7. Cancer Gene Ther. 1999 Jan-Feb; 6(1):14-20. PMID: 10078959.
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  292. Saeki Y, Ichikawa T, Saeki A, Chiocca EA, Tobler K, Ackermann M, Breakefield XO, Fraefel C. Herpes simplex virus type 1 DNA amplified as bacterial artificial chromosome in Escherichia coli: rescue of replication-competent virus progeny and packaging of amplicon vectors. Hum Gene Ther. 1998 Dec 10; 9(18):2787-94. PMID: 9874276.
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  293. Yoon SS, Carroll NM, Chiocca EA, Tanabe KK. Cancer gene therapy using a replication-competent herpes simplex virus type 1 vector. Ann Surg. 1998 Sep; 228(3):366-74. PMID: 9742919; PMCID: PMC1191493.
  294. Chung RY, Chiocca EA. Gene therapy for tumors of the central nervous system. Surg Oncol Clin N Am. 1998 Jul; 7(3):589-602. PMID: 9624219.
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  295. Rainov NG, Dobberstein KU, Sena-Esteves M, Herrlinger U, Kramm CM, Philpot RM, Hilton J, Chiocca EA, Breakefield XO. New prodrug activation gene therapy for cancer using cytochrome P450 4B1 and 2-aminoanthracene/4-ipomeanol. Hum Gene Ther. 1998 Jun 10; 9(9):1261-73. PMID: 9650611.
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  296. Herrlinger U, Kramm CM, Aboody-Guterman KS, Silver JS, Ikeda K, Johnston KM, Pechan PA, Barth RF, Finkelstein D, Chiocca EA, Louis DN, Breakefield XO. Pre-existing herpes simplex virus 1 (HSV-1) immunity decreases, but does not abolish, gene transfer to experimental brain tumors by a HSV-1 vector. Gene Ther. 1998 Jun; 5(6):809-19. PMID: 9747461.
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  297. Shafqat S, Elkind MS, Chiocca EA, Takeoka M, Koroshetz WJ. Petroclival meningioma presenting with pathological laughter. Neurology. 1998 Jun; 50(6):1918-9. PMID: 9633764.
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  298. Chase M, Chung RY, Chiocca EA. An oncolytic viral mutant that delivers the CYP2B1 transgene and augments cyclophosphamide chemotherapy. Nat Biotechnol. 1998 May; 16(5):444-8. PMID: 9592392.
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  299. Rainov NG, Dobberstein KU, Heidecke V, Dorant U, Chase M, Kramm CM, Chiocca EA, Breakefield XO. Long-term survival in a rodent brain tumor model by bradykinin-enhanced intra-arterial delivery of a therapeutic herpes simplex virus vector. Cancer Gene Ther. 1998 May-Jun; 5(3):158-62. PMID: 9622099.
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  300. Moore A, Basilion JP, Chiocca EA, Weissleder R. Measuring transferrin receptor gene expression by NMR imaging. Biochim Biophys Acta. 1998 Apr 24; 1402(3):239-49. PMID: 9606982.
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  301. Wei MX, Li F, Ono Y, Gauldie J, Chiocca EA. Effects on brain tumor cell proliferation by an adenovirus vector that bears the interleukin-4 gene. J Neurovirol. 1998 Apr; 4(2):237-41. PMID: 9584960.
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  302. Aghi M, Kramm CM, Chou TC, Breakefield XO, Chiocca EA. Synergistic anticancer effects of ganciclovir/thymidine kinase and 5-fluorocytosine/cytosine deaminase gene therapies. J Natl Cancer Inst. 1998 Mar 04; 90(5):370-80. PMID: 9498487.
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  303. Husain N, Chiocca EA, Rainov N, Louis DN, Zervas NT. Co-expression of Fas and Fas ligand in malignant glial tumors and cell lines. Acta Neuropathol. 1998 Mar; 95(3):287-90. PMID: 9542594.
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  304. Rainov NG, Sena-Esteves M, Fraefel C, Dobberstein KU, Chiocca EA, Breakefield XO. A chimeric fusion protein of cytochrome CYP4B1 and green fluorescent protein for detection of pro-drug activating gene delivery and for gene therapy in malignant glioma. Adv Exp Med Biol. 1998; 451:393-403. PMID: 10026902.
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  305. Nicolò M, Chiocca EA. Marker gene transfer and oncolysis of human Y79 retinoblastoma cells mediated by herpes simplex virus mutants. Ophthalmic Res. 1998; 30(1):30-6. PMID: 9483585.
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  306. Kramm CM, Chase M, Herrlinger U, Jacobs A, Pechan PA, Rainov NG, Sena-Esteves M, Aghi M, Barnett FH, Chiocca EA, Breakefield XO. Therapeutic efficiency and safety of a second-generation replication-conditional HSV1 vector for brain tumor gene therapy. Hum Gene Ther. 1997 Nov 20; 8(17):2057-68. PMID: 9414254.
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  307. Ono Y, Ikeda K, Wei MX, Harsh GR, Tamiya T, Chiocca EA. Regression of experimental brain tumors with 6-thioxanthine and Escherichia coli gpt gene therapy. Hum Gene Ther. 1997 Nov 20; 8(17):2043-55. PMID: 9414253.
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  308. Carroll NM, Chase M, Chiocca EA, Tanabe KK. The effect of ganciclovir on herpes simplex virus-mediated oncolysis. J Surg Res. 1997 May; 69(2):413-7. PMID: 9224416.
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  309. Kramm CM, Rainov NG, Sena-Esteves M, Barnett FH, Chase M, Herrlinger U, Pechan PA, Chiocca EA, Breakefield XO. Long-term survival in a rodent model of disseminated brain tumors by combined intrathecal delivery of herpes vectors and ganciclovir treatment. Hum Gene Ther. 1996 Oct 20; 7(16):1989-94. PMID: 8930659.
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  310. Pechan PA, Fotaki M, Thompson RL, Dunn R, Chase M, Chiocca EA, Breakefield XO. A novel 'piggyback' packaging system for herpes simplex virus amplicon vectors. Hum Gene Ther. 1996 Oct 20; 7(16):2003-13. PMID: 8930661.
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  311. Megerian CA, Chiocca EA, McKenna MJ, Harsh GF, Ojemann RG. The subtemporal-transpetrous approach for excision of petroclival tumors. Am J Otol. 1996 Sep; 17(5):773-9. PMID: 8892575.
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  312. Carroll NM, Chiocca EA, Takahashi K, Tanabe KK. Enhancement of gene therapy specificity for diffuse colon carcinoma liver metastases with recombinant herpes simplex virus. Ann Surg. 1996 Sep; 224(3):323-9; discussion 329-30. PMID: 8813260; PMCID: PMC1235374.
  313. Tamiya T, Ono Y, Wei MX, Mroz PJ, Moolten FL, Chiocca EA. Escherichia coli gpt gene sensitizes rat glioma cells to killing by 6-thioxanthine or 6-thioguanine. Cancer Gene Ther. 1996 May-Jun; 3(3):155-62. PMID: 8725879.
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  314. Kramm CM, Rainov NG, Sena-Esteves M, Chase M, Pechan PA, Chiocca EA, Breakefield XO. Herpes vector-mediated delivery of marker genes to disseminated central nervous system tumors. Hum Gene Ther. 1996 Feb 10; 7(3):291-300. PMID: 8835217.
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  315. Rainov NG, Zimmer C, Chase M, Kramm CM, Chiocca EA, Weissleder R, Breakefield XO. Selective uptake of viral and monocrystalline particles delivered intra-arterially to experimental brain neoplasms. Hum Gene Ther. 1995 Dec; 6(12):1543-52. PMID: 8664379.
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  316. Muldoon LL, Nilaver G, Kroll RA, Pagel MA, Breakefield XO, Chiocca EA, Davidson BL, Weissleder R, Neuwelt EA. Comparison of intracerebral inoculation and osmotic blood-brain barrier disruption for delivery of adenovirus, herpesvirus, and iron oxide particles to normal rat brain. Am J Pathol. 1995 Dec; 147(6):1840-51. PMID: 7495307; PMCID: PMC1869962.
  317. Kramm CM, Sena-Esteves M, Barnett FH, Rainov NG, Schuback DE, Yu JS, Pechan PA, Paulus W, Chiocca EA, Breakefield XO. Gene therapy for brain tumors. Brain Pathol. 1995 Oct; 5(4):345-81. PMID: 8974620.
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  318. Tamiya T, Wei MX, Chase M, Ono Y, Lee F, Breakefield XO, Chiocca EA. Transgene inheritance and retroviral infection contribute to the efficiency of gene expression in solid tumors inoculated with retroviral vector producer cells. Gene Ther. 1995 Oct; 2(8):531-8. PMID: 8593603.
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  319. Wei MX, Tamiya T, Rhee RJ, Breakefield XO, Chiocca EA. Diffusible cytotoxic metabolites contribute to the in vitro bystander effect associated with the cyclophosphamide/cytochrome P450 2B1 cancer gene therapy paradigm. Clin Cancer Res. 1995 Oct; 1(10):1171-7. PMID: 9815909.
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  320. Wei MX, Tamiya T, Hurford RK, Boviatsis EJ, Tepper RI, Chiocca EA. Enhancement of interleukin-4-mediated tumor regression in athymic mice by in situ retroviral gene transfer. Hum Gene Ther. 1995 Apr; 6(4):437-43. PMID: 7612701.
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  321. Chiocca EA. Brain tumor gene therapy in mice with a novel "suicide" gene: the cyclophosphamide-activating CYP2B1 gene. Clin Neurosurg. 1995; 42:370-82. PMID: 8846604.
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  322. Tamiya T, Ohmoto T, Wei MX, Breakfield XO, Chiocca EA. [Gene therapy for brain tumors: gene therapy for malignant brain tumors using prodrug-sensitivity genes (series 4)]. No Shinkei Geka. 1994 Dec; 22(12):1099-110. PMID: 7845504.
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  323. Boviatsis EJ, Park JS, Sena-Esteves M, Kramm CM, Chase M, Efird JT, Wei MX, Breakefield XO, Chiocca EA. Long-term survival of rats harboring brain neoplasms treated with ganciclovir and a herpes simplex virus vector that retains an intact thymidine kinase gene. Cancer Res. 1994 Nov 15; 54(22):5745-51. PMID: 7954393.
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  324. Chiocca EA, Boviatsis EJ, Westmark RM, Short MP, Richardson EP, Zervas NT. Deep sylvian fissure meningioma without dural attachment in an adult: case report. Neurosurgery. 1994 Nov; 35(5):944-6; discussion 946. PMID: 7838346.
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  325. Boviatsis EJ, Scharf JM, Chase M, Harrington K, Kowall NW, Breakefield XO, Chiocca EA. Antitumor activity and reporter gene transfer into rat brain neoplasms inoculated with herpes simplex virus vectors defective in thymidine kinase or ribonucleotide reductase. Gene Ther. 1994 Sep; 1(5):323-31. PMID: 7584098.
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  326. Wei MX, Tamiya T, Chase M, Boviatsis EJ, Chang TK, Kowall NW, Hochberg FH, Waxman DJ, Breakefield XO, Chiocca EA. Experimental tumor therapy in mice using the cyclophosphamide-activating cytochrome P450 2B1 gene. Hum Gene Ther. 1994 Aug; 5(8):969-78. PMID: 7948146.
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  327. Pakzaban P, Chiocca EA. Nerve growth factor protects against herpes simplex virus type 1 neurotoxicity in the rat striatum. Neuroreport. 1994 Apr 14; 5(8):993-6. PMID: 8061311.
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  328. Boviatsis EJ, Chase M, Wei MX, Tamiya T, Hurford RK, Kowall NW, Tepper RI, Breakefield XO, Chiocca EA. Gene transfer into experimental brain tumors mediated by adenovirus, herpes simplex virus, and retrovirus vectors. Hum Gene Ther. 1994 Feb; 5(2):183-91. PMID: 8186298.
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  329. Yu JS, Wei MX, Chiocca EA, Martuza RL, Tepper RI. Treatment of glioma by engineered interleukin 4-secreting cells. Cancer Res. 1993 Jul 01; 53(13):3125-8. PMID: 8319220.
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  330. Lee JK, Sobel RA, Chiocca EA, Kim TS, Martuza RL. Growth of human acoustic neuromas, neurofibromas and schwannomas in the subrenal capsule and sciatic nerve of the nude mouse. J Neurooncol. 1992 Oct; 14(2):101-12. PMID: 1432035.
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  331. Gentile V, Saydak M, Chiocca EA, Akande O, Birckbichler PJ, Lee KN, Stein JP, Davies PJ. Isolation and characterization of cDNA clones to mouse macrophage and human endothelial cell tissue transglutaminases. J Biol Chem. 1991 Jan 05; 266(1):478-83. PMID: 1670766.
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  332. Lee JK, Choi B, Sobel RA, Chiocca EA, Martuza RL. Inhibition of growth and angiogenesis of human neurofibrosarcoma by heparin and hydrocortisone. J Neurosurg. 1990 Sep; 73(3):429-35. PMID: 1696626.
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  333. Chiocca EA, Choi BB, Cai WZ, DeLuca NA, Schaffer PA, DiFiglia M, Breakefield XO, Martuza RL. Transfer and expression of the lacZ gene in rat brain neurons mediated by herpes simplex virus mutants. New Biol. 1990 Aug; 2(8):739-46. PMID: 2178004.
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  334. Lee JK, Kim TS, Chiocca EA, Medhkour A, Martuza RL. Growth of human schwannomas in the subrenal capsule of the nude mouse. Neurosurgery. 1990 Apr; 26(4):598-605. PMID: 2330081.
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  335. Martuza RL, Chiocca EA, Jenike MA, Giriunas IE, Ballantine HT. Stereotactic radiofrequency thermal cingulotomy for obsessive compulsive disorder. J Neuropsychiatry Clin Neurosci. 1990; 2(3):331-6. PMID: 2136095.
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  336. Chiocca EA, Davies PJ, Stein JP. Regulation of tissue transglutaminase gene expression as a molecular model for retinoid effects on proliferation and differentiation. J Cell Biochem. 1989 Mar; 39(3):293-304. PMID: 2565341.
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  337. Davies PJ, Basilion JP, Chiocca EA, Johnson J, Poddar S, Stein JP. Retinoids as generalized regulators of cellular growth and differentiation. Am J Med Sci. 1988 Sep; 296(3):164-70. PMID: 2902793.
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  338. Chiocca EA, Davies PJ, Stein JP. The molecular basis of retinoic acid action. Transcriptional regulation of tissue transglutaminase gene expression in macrophages. J Biol Chem. 1988 Aug 15; 263(23):11584-9. PMID: 2900242.
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  339. Davies PJ, Chiocca EA, Stein JP. Retinoid--regulated expression of tissue transglutaminase in normal and leukemic myeloid cells. Adv Exp Med Biol. 1988; 231:63-71. PMID: 2901195.
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  340. Davies PJ, Chiocca EA, Basilion JP, Poddar S, Stein JP. Transglutaminases and their regulation: implications for polyamine metabolism. Adv Exp Med Biol. 1988; 250:391-401. PMID: 2908219.
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